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  • kinase
  • On a molecular level, constructs derived from Survivin ΔXIAP and T34A phospho-mutant overexpressing clones did not co-immunoprecipitate with the DNA repair protein DNA-dependent protein kinase catalytic subunit (DNA-PKcs), whereas Survivin wt and T34D constructs co-precipitated with the protein. (tu-darmstadt.de)
  • We compare the cellular efficacy of two selective and cell permeable inhibitors of the antiapoptotic kinase CK2. (hindawi.com)
  • TAK1, a member of the MAP kinase kinase kinase family, and its activator, TAB1, participate in the bone morphogenetic protein (BMP) signaling pathway involved in mesoderm induction and patterning in early Xenopus embryos. (embopress.org)
  • Cytoplasmic MCM2 decreased the activity of KX2-391 2HCl proteins phosphatase 2A (PP2A) leading to the following hyperphosphorylation of DNA-dependent proteins kinase (DNA-PK). (onetownmanyvoices.com)
  • Inhibitor of the serine/threonine-protein kinase PAK4. (uniprot.org)
  • Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity. (uniprot.org)
  • The C-terminal, noncatalytic region of CENP-E is not only sufficient to specify localization to kinetochores, but it also mediates interaction of CENP-E with the serine/threonine kinase BubR1, a key effector of mitotic checkpoint signaling that forms complexes with the checkpoint proteins Cdc20, Bub3, and Mad2 to inhibit the ubiquitin ligase activity of the anaphase promoting complex APC/C CDC20 ( 4 - 7 ). (pnas.org)
  • Studies combining detailed light and electron microscopy, inhibitors of KSP/Eg5 and Aurora kinase, and siRNA-mediated depletion of CENP-E showed that loss of CENP-E correlated with a failure of monooriented chromosomes to congress to the spindle midzone ( 12 ). (pnas.org)
  • The mammalian target of rapamycin (mTOR) is a downstream effector of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway and a central modulator of cell proliferation in malignant gliomas. (aacrjournals.org)
  • The signaling pathway composed of phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) plays a central role in the regulation of cell proliferation, growth, differentiation, and survival ( 2 , 3 ). (aacrjournals.org)
  • Rapamycin and its derivatives, CCI-779 and RAD001, specifically inhibit the function of mTOR by blocking the phosphorylation of downstream molecules, such as p70S6 kinase (p70S6K) and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), leading to G 1 -phase cell cycle arrest ( 7 , 8 ). (aacrjournals.org)
  • Protein kinase inhibitor pyrrol derivate 1-(4-Cl-benzyl)-3-Cl-4-(CF 3 -fenylamino)-1Н-pyrrol-2,5-dione (MI-1) (Figure 1 ) has been synthesized at Chemistry Department of Taras Shevchenko National University of Kyiv. (hindawi.com)
  • antitumor
  • These results indicate that rapamycin exerts its antitumor effect on malignant glioma cells by inducing autophagy and suggest that in malignant glioma cells a disruption of the PI3K/Akt signaling pathway could greatly enhance the effectiveness of mTOR inhibitors. (aacrjournals.org)
  • In our previous studies we showed antitumor and anti-inflammatory activities of protein kinases inhibitor pyrrol derivate 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2,5-dione (MI-1) on rat colon cancer model. (hindawi.com)
  • Regulators
  • The ability of Dox to stimulate release of mature (17-kDa) IL-1β was nearly equivalent in wild-type (WT) BMDC, Casp1 −/− Casp11 −/− BMDC, WT BMDC treated with the caspase-1 inhibitor YVAD, and BMDC lacking the inflammasome regulators ASC, NLRP3, or NLRC4. (jimmunol.org)
  • However, very little is known about protein phosphatases and their regulators in the parasite. (deepdyve.com)
  • activation
  • Activation of p38 MAPK signaling due to culture stress might suppress the proliferation of HCECs, whereas a p38 MAPK inhibitor can counteract this activation and enable efficient in vitro HCEC expansion. (arvojournals.org)
  • Notably, Dox-induced production of mature IL-1β was temporally correlated with caspase-8 activation in WT cells and greatly suppressed in Casp8 −/− Rip3 −/− or Trif −/− BMDC, as well as in WT BMDC treated with the caspase-8 inhibitor, IETD. (jimmunol.org)
  • Activation of TLRs or receptors for proinflammatory cytokines (including IL-1β per se) induces the NF-κB-dependent expression of proIL-1β (33 kDa) as a cytosolic, biologically inactive precursor protein. (jimmunol.org)
  • The most intensively studied inflammasome comprises an oligomeric complex of procaspase-1 with the NLRP3 and ASC adapter proteins that rapidly assembles in response to diverse stress stimuli such as increased reactive oxygen species (ROS) ( 3 ), mitochondrial dysfunction ( 4 ), perturbation of intracellular ion homeostasis ( 5 - 7 ), disruption of lysosomal membrane integrity ( 8 ), and activation of deubiquitinases ( 9 - 11 ). (jimmunol.org)
  • chromosome
  • kinesin-7) is a kinetochore-associated kinesin motor protein with an essential and exclusive role in metaphase chromosome alignment and satisfaction of the mitotic checkpoint ( 1 ). (pnas.org)
  • kinases
  • Several studies have demonstrated the importance of phosphorylations by protein kinases during the life cycle of T. gondii. (deepdyve.com)
  • amyloid
  • Neurotoxins such as amyloid- β , tau protein, and α -synuclein trigger abnormal calcineurin/NFAT signaling activities. (hindawi.com)
  • dimeric
  • CENP-E is a large dimeric protein consisting of an N-terminal kinesin motor domain tethered to a globular C-terminal domain through an extended coiled-coil rod domain ( 2 , 3 ). (pnas.org)
  • molecular
  • research of cellular and molecular interplays between disease fighting capability and cancerous cells is gaining tremendous momentum throughout the world. (welbourneprimary.com)
  • Survivin
  • To investigate in more detail the role of Survivin in cellular radiation response and tumour cell motility, the present study aimed to establish and stably express several Survivin enhanced green fluorescent protein (EGFP)-tagged deletion or phosphorylation mutant constructs in SW480 colorectal cancer cells. (tu-darmstadt.de)
  • Survivin, das kleinste und funktionell einzigartige Mitglied der Inhibitor of Apoptosis Protein (IAP) Familie ist in der Mehrzahl maligner Zellen überexpremiert und stellt einen wesentlichen prädiktiven molekularen Marker für eine Metastasierung und das Überleben von Patienten nach Strahlentherapie dar. (tu-darmstadt.de)
  • Um die Rolle von Survivin in der zellulären Strahlenantwort und Tumorzellmotilität detaillierter zu untersuchen, war es Ziel der vorliegenden Arbeit, eine Reihe von grün fluoreszierendes Protein (GFP) markierten Survivin Deletions- und Phosphorylierungsmutanten zu generieren und stabil exprimierende Klone kolorektaler SW480 Karzinomzellen herzustellen. (tu-darmstadt.de)
  • The inhibitor of apoptosis (IAP) protein survivin is found overexpressed in virtually all human cancers and has been shown to correlate with poor prognosis. (aacrjournals.org)
  • Using dual-affinity protein purification and mass-spectrometry, survivin was found associating directly with clathrin, TNFR1, and the transferrin receptor (TfR), indicating that the process of survivin uptake may be through endocytosis. (aacrjournals.org)
  • biological
  • The biological effects of the two inhibitors have been analyzed by performing clonogenic, spheroid formation, and wound-healing assays: we observed a permanent inhibition of cell survival and migration in TDB-treated cells even after the inhibitor removal, while in the case of CX-4945 only its maintenance for the whole duration of the assay insured a persisting effect. (hindawi.com)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • cells
  • Interestingly, a PI3K inhibitor, LY294002, and an Akt inhibitor, UCN-01 (7-hydroxystaurosporine), both synergistically sensitized U87-MG and T98G cells as well as U373-MG cells to rapamycin by stimulating the induction of autophagy. (aacrjournals.org)
  • cell
  • When poly(I:C) is combined to the IAP inhibitor RMT 5265, a cooperative effect in apoptosis induction and/or inhibition of clonogenic growth is obtained in a large fraction of carcinoma and melanoma cell lines. (biomedcentral.com)
  • type
  • Type 1 plasminogen activator inhibitor (PAI-1) may be markedly increased in the plasma of patients with endotoxemia and/or renal disease. (semanticscholar.org)
  • p>This indicates the type of evidence that supports the existence of the protein. (uniprot.org)
  • Doppel proteins (Dpl) is normally a paralog from the cellular type of the prion proteins (PrPC), writing common structural and biochemical properties together. (achemmic.com)
  • Introduction Prion illnesses, referred to as transmissible spongiform encephalopathies or TSE generally, are fatal neurodegenerative disorders because of the conversion from the cellular type of the prion proteins (PrPC) into an unusual, pathogenic and proteinase-resistant type of the same proteins (PrPSc). (achemmic.com)
  • whereas
  • HCECs cultured with SB203580 exhibited hexagonal morphology and similar size and morphology, whereas control HCECs cultured without inhibitor exhibited monolayer morphology and varied in size and morphology. (arvojournals.org)
  • viral
  • Toll-like receptor 3, a membrane receptor of double strand RNAs, is a major effector of the immune response against viral pathogens at the cellular and systemic level. (biomedcentral.com)
  • commonly
  • p>This subsection of the 'Names and Taxonomy' section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein. (uniprot.org)