TumorsTherapiesCheckpointTumor microenvironmentBiomarkersChimericFrontiersCancersAntitumorDendriticImmunosuppressive mechanismsReceptorsClinical trialsImmunogenicityApproachesImmunologicalInhibitoryAugmentUnderstand the mechanismsAnti-tumor activityTherapeuticTherapy2016Antigen-specificHematologicalResistanceOvercomeTransferDevelopmentTranslationalPatientsCellsTypesEffectsNaturalResearchPotential
Tumors7
- Current cellular adoptive therapies consist of the ex-vivo expansion of TILs from resected tumors and transferred back to the patients' bodies with support of interleukin -2 (IL-2). (wikipedia.org)
- This therapy has shown to be more effective in treating solid tumors than other cellular adoptive immunotherapies such as CAR T cell therapy. (wikipedia.org)
- Recently, the lab of Dr. P. Agostinis documented that immunogenic cell death mediated by ER stress can be harnessed to develop novel and clinically relevant, next-generation dendritic cell-based immunotherapies for brain tumors. (euroacadti.eu)
- Unlike chemotherapy or radiation which directly attack tumors, immunotherapy helps train the immune cells to recognize markers on cancer cells and boosts their killing capability. (theusaknowledge.net)
- Dr. Rezvani's lab studies the role of natural killer (NK) cells in mediating immunity against hematologic malignancies as well as solid tumors, and seeks to understand the mechanisms of tumor-induced NK cell dysfunction. (cancerprogress.live)
- Findings from her lab have led to the approval and funding of Phase I/II studies of immunotherapy in patients with hematologic malignancies and solid tumors, as well as the first-in-human clinical trial of off-the-shelf CAR-transduced cord blood NK cells in patients with relapsed/refractory lymphoid malignancies. (cancerprogress.live)
- Optimization of the design of CAR vectors, exploration of new targets, addition of safe switches and combination with other treatments bring new vitality to the CAR-T cell based immunotherapy against solid tumors. (ijbs.com)
Therapies12
- The primary types of cellular adoptive immunotherapies are T cell therapies. (wikipedia.org)
- Other therapies include CAR-T therapy, CAR-NK therapy, macrophage-based immunotherapy and dendritic cell therapy. (wikipedia.org)
- Although immunotherapy with immune checkpoint blockade and targeted therapy was used to treat and improve the survival of patients with several types of cancers, such as non-small cell lung cancer, many patients still develop disease progression even after receiving these therapies. (wikipedia.org)
- In current clinical development, targeting CD19 + B cell malignancies, which include acute and chronic B-cell leukaemia and B-cell non-Hodgkin lymphomas (NHLs), with anti-CD19 CAR-T cells is one of the most advanced adoptive T-cell therapies and has been approved by the FDA. (nature.com)
- Despite their efficiency, adoptive T-cell therapies show unique toxicities, which are distinct from those seen with conventional chemotherapies, monoclonal antibodies (mAbs), and small-molecule-targeted therapies. (nature.com)
- Unfortunately, many patients still progress and acquire resistance to immunotherapy and molecularly targeted therapies. (biomedcentral.com)
- The Novina Lab is using CRISPR-Cas9 based systems to develop novel approaches to regulate key inhibitory genes for adoptive cellular therapies. (dana-farber.org)
- Only 10% of the human population is homozygous for this polymorphism, suggesting that genetic manipulation of NK cells to express CD16-158V prior to adoptive transfer may improve clinical success not only of NK cell therapies but also anti-tumor IgG1 antibodies. (maxcyte.com)
- A new era of cancer therapeutic modalities, including immunotherapies and targeted therapies, has led to a paradigm shift in cancer treatment, inducing effective and durable clinical responses for a significant number of patients suffering from various types of malignancy. (mdpi.com)
- Combinatorial treatments, including immune checkpoint inhibitors, adoptive cellular therapies, molecular targeted therapies, and cancer vaccines have overcome cancer heterogeneity, inducing resistance mechanisms, and thus reinforcing the impact of these novel cancer therapeutic approaches. (mdpi.com)
- Success in discovery and development of immuno-oncology therapies relies on a knowledge of the underlying cellular mechanisms of the immune system and the. (thermofisher.com)
- Here, we review current knowledge of the current status of tumor immunotherapy and the types and effects of post-translational modifications of proteins, hoping to improve new ideas for the types of therapies. (cmbr-journal.com)
Checkpoint3
- Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). (biomedcentral.com)
- T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
- Targeting immune checkpoint protein interactions is one form of cancer immunotherapy that offers a novel way to attack tumor cells. (thermofisher.com)
Tumor microenvironment3
- 2) Achieving full function of T cells and tumor microenvironment (TME) with different immunosuppressive mechanisms is another primary concern. (wikipedia.org)
- The major areas of recent interest in the lab have been augmentation of anti-tumor immune effects, the tumor microenvironment, mechanisms of T cell dysfunction, and adoptive T cell transfer with an increasing focus on lung cancer. (upenn.edu)
- Thus, addressing the presence of immunosuppressive myeloid cell populations in the periphery and tumor microenvironment of patients with cancer is likely to be required for effective NK cell-based immunotherapy. (elifesciences.org)
Biomarkers1
- This included sessions dedicated to systems biology on immunotherapy, immunogenicity and gene expression profiling, biomarkers, and combination treatment strategies. (biomedcentral.com)
Chimeric2
- Chimeric antigen receptor T-cells (CAR-T) are predominantly used in cancer immunotherapy. (wikipedia.org)
- In recent years, personalized cancer immunotherapy in the form of chimeric antigen receptors (CARs) in T cells (CAR T cells) has effectively treated some forms of leukemia and lymphoma. (thermofisher.com)
Frontiers1
- She is on the editorial board of JCO and Blood and is the Specialty Chief Editor for the cancer immunity and immunotherapy section, Frontiers in Immunology . (cancerprogress.live)
Cancers5
- Current efforts focus on applying these insights to adoptive T cell therapy for human solid cancers. (dana-farber.org)
- This review summarized the associations between various types of diabetes and cancers and updated available evidence of underlying mechanisms between diabetes and cancers. (frontiersin.org)
- However, the underlying mechanisms between various types of diabetes and cancers have not yet been summarized. (frontiersin.org)
- After decades of research, immunotherapy has now emerged as a revolutionary approach against certain types of cancers. (theusaknowledge.net)
- Recommendation B. Create a translational science network devoted exclusively to immunotherapy approaches to treat and prevent adult cancers. (nih.gov)
Antitumor3
- To determine the mechanisms of how innate immune activation via lymphodepletion potentiated antitumor T cell immunity, we utilized the pmel-1 melanoma mouse model. (biomedcentral.com)
- Recent advances in immuno-oncology (I-O) research are paving the way for the discovery of novel classes of cancer therapeutics that enhance or enable antitumor immune responses, overcome tumor evasion mechanisms, and promote conditions that favor immune protection. (thermofisher.com)
- Immunological and translational aspects of NK cell-based antitumor immunotherapies. (springer.com)
Dendritic1
- His main scientific contributions in the last 10 years relate to antigen presentation in dendritic cells and immunotherapy. (euroacadti.eu)
Immunosuppressive mechanisms1
- Moreover, CAR-T cells are vulnerable to immunosuppressive mechanisms. (nature.com)
Receptors1
- Adoptive cell transfer involves engineering patient's own T-cells to create receptors on their surface that recognize specific tumor antigens. (theusaknowledge.net)
Clinical trials4
- Our department is developing novel approaches for immunotherapy, and we closely collaborate with our clinical colleagues to advance important discoveries to clinical trials. (dana-farber.org)
- We believe that this technology will substantially enhance our ability to study immunological mechanisms in patients enrolled in clinical trials of novel immunotherapies. (dana-farber.org)
- The purpose of this specific FOA is to establish a Data Resource associated with clinical trials in cellular immunotherapy as a component of the Immuno-Oncology Translation Network (IOTN). (nih.gov)
- She is on the Center for International Blood and Marrow Transplant (CIBMTR) clinical trials advisory committee, a member of the BMT CTN Cell and Gene Therapy, a member of the Hematologic and Immunologic Gene & Cell Therapy Committee and serves on the ASH Task Force on Immunotherapies. (cancerprogress.live)
Immunogenicity1
- Melanoma was the first type of tumor that provided insight into cancer immunotherapy due to its high immunogenicity. (wikipedia.org)
Approaches2
- Non-viral engineering of NK cells using MaxCyte ® mRNA electroporation provides significant benefits including high efficiency and low toxicity as well as clinical scalability enabling rapid development of novel adoptive cell therapy approaches. (maxcyte.com)
- Thus, it is imperative to develop more competent and safer immunotherapy approaches by optimizing the design of CAR vectors, exploring new targets, incorporating conditional safe switches and combining with other strategies. (ijbs.com)
Immunological1
- His research is focused on the mechanisms that regulate the immunological response of T lymphocytes, especially strategies to manipulate those responses in clinically relevant areas, including autoimmunity, allergies, vaccinations, and tumor therapy. (euroacadti.eu)
Inhibitory2
- We are also working on a novel technique for isolation of therapeutic antibodies from patients who respond to immunotherapies, based on the observation that such patients can mount immune responses against inhibitory immune molecules (Wucherpfennig and Dranoff Labs). (dana-farber.org)
- On the other hand, γδ T cells are also subject to inhibitory mechanisms of the tumor micromilieu. (explorationpub.com)
Augment2
- Collectively, our results identify how and when to administer TLR agonists to augment T cell-based immunotherapy in the absence or presence of host preconditioning for treatment of advanced malignancies. (biomedcentral.com)
- By targeting these critical regulators of immune response to cancer, immunotherapies augment the natural defenses of the body to attack malignant cells across multiple pathways. (theusaknowledge.net)
Understand the mechanisms2
- The main interests of the Dr. Alitalo's group is to understand the mechanisms of development of blood vessels from preexisting ones in a process called angiogenesis and to learn analogous mechanisms of lymphangiogenesis. (euroacadti.eu)
- Further investigation is needed to understand the mechanisms of NK-MSC interaction and its implications. (springer.com)
Anti-tumor activity1
- One mechanism of NK cell anti-tumor activity is antibody-dependent cellular cytotoxicity (ADCC) induced via Fc receptor (CD16) binding to antibodies. (maxcyte.com)
Therapeutic1
- Tumor immunotherapy refers to exogenous intervention of the body's immune system, restart and maintain the "tumor-immune" cycle, restore and improve the anti-immune response of the group, strengthen the recognition and killing ability of tumor cells, so as to achieve the therapeutic effect of controlling or even clarifying the tumor specifically. (cmbr-journal.com)
Therapy17
- A major application of cellular adoptive therapy is cancer treatment, as the immune system plays a vital role in the development and growth of cancer. (wikipedia.org)
- Cellular adoptive therapy is another alternative for these patients. (wikipedia.org)
- Lymphodepletion enhances adoptive T cell transfer (ACT) therapy by activating the innate immune system via microbes released from the radiation-injured gut. (biomedcentral.com)
- CONCLUSION: Our findings suggest that the proportion of LDL-R+ T cells may serve as an early assessment parameter for evaluating TCR-T cell quality, possibly facilitating the functional and economical improvement of current adoptive therapy. (bvsalud.org)
- The report includes a compilation of currently active projects in research and development of passive and active immunotherapy and adoptive cell therapy targeting PRAME. (pipelinereview.com)
- Since 2000 PA is the group leader of the Cell Death Research & Therapy lab, at the Department of Cellular & Molecular Medicine of the KU Leuven, and in 2008 she became Full Professor at the same Institution. (euroacadti.eu)
- haNKs represent an 'off the shelf' NK cellular therapy available for pre-clinical and clinical study. (elifesciences.org)
- In this blog, we explore the different types of immunotherapies, their mechanisms of action, current uses in cancer treatment, limitations, and the exciting future possibilities of this transformative therapy. (theusaknowledge.net)
- Comprehensive solutions to support CAR T-cell therapy research from T-cell engineering to sequencing Adoptive cell transfer is a rapidly emerging area of immuno-oncology research. (thermofisher.com)
- Adoptive cell therapy (ACT) has emerged as an effective approach in immuno-oncology research. (thermofisher.com)
- Understanding of molecular mechanisms in natural killer cell therapy. (springer.com)
- Katy Rezvani, MD, PhD is Sally Cooper Murray Chair in Cancer Research, Professor of Medicine, Chief of the Section for Cellular Therapy, Director of Translational Research and Medical Director of the GMP Facility at MD Anderson Cancer Center . (cancerprogress.live)
- She has over 170 peer-reviewed publications related to immunotherapy, cellular therapy, and hematopoietic transplantation. (cancerprogress.live)
- Dr. Rezvani has served on the organizing committees of the American Society of Hematology, Society for Natural Immunity, International Society of Cell Therapy, and Transplantation and Cellular Therapy Meetings of ASBMT and CIBMTR. (cancerprogress.live)
- She serves as the Executive Scientific Leader of the Adoptive Cell therapy Platform at MD Anderson and is the co-Leader of the Stem Cell Transplantation and Cellular Therapy Program of the MD Anderson Cancer Center Support Grant. (cancerprogress.live)
- Cancer-specific adoptive T cell therapy has achieved successful milestones in multiple clinical treatments. (biomedcentral.com)
- CAR-T cell therapy has achieved outstanding progresses in clinical observations, which makes it even more attractive in the development of cancer adoptive immunotherapy. (ijbs.com)
20161
- 2016). Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells. (springer.com)
Antigen-specific1
- He received a U19 grant to develop better immunologic tools to interrogate human immune responses and ultimately patented the MHC cellular microarray to detect and functionally characterize antigen-specific T cell states. (cancerprogress.live)
Hematological1
- The major application of CAR-T immunotherapy is to treat hematological malignancies, such as multiple myeloma, chronic lymphocytic leukemia, acute lymphoblastic leukemia and lymphoma. (wikipedia.org)
Resistance2
- To bypass resistance, combination treatment with immunotherapies and single or multiple TKIs have been shown to improve prognosis compared to monotherapy. (biomedcentral.com)
- Natural killer (NK) cell-based immunotherapy may overcome genetic mechanisms of resistance to T cell-based immunotherapy through antigen- and MHC-independent recognition of malignant cells. (elifesciences.org)
Overcome1
- Failed T cell-based immunotherapies in the presence of genomic alterations in antigen presentations pathways may be overcome by NK cell-based immunotherapy. (elifesciences.org)
Transfer3
- The lab has extensive experience in lentiviral transduction of human T cells and retroviral transduction of mouse T cells for use in adoptive T cell transfer. (upenn.edu)
- NK cells play a pivotal role in rapid and highly efficient cancer surveillance and represent a promising avenue for adoptive cell transfer either as a mono- or combination immunotherapy. (maxcyte.com)
- The main challenge for the success of this approach is to obtain a great quantity of activated NK cells for adoptive transfer. (springer.com)
Development2
- The discovery and development of effective cancer immunotherapy requires a better understanding of the tumor and its surrounding environment. (thermofisher.com)
- Daniel S. Chen, MD, PhD, is the Chief Medical Officer for IGM Biosciences , and former Vice President, Global Head of Cancer Immunotherapy Development at Genentech/Roche. (cancerprogress.live)
Translational1
- In this Special Issue, we will publish cutting edge papers dealing with various aspects of how γδ T cells interact with tumor cells, including translational perspectives for improving the clinical application of γδ T cells in immunotherapy. (explorationpub.com)
Patients1
- Collectively, the BsAb-armed T cell technology represents a simple, time-saving, and highly safe method to generate highly pure cancer-specific effector T cells, thereby providing an affordable T cell immunotherapy to patients. (biomedcentral.com)
Cells3
- NK cells have been seen as potential agents in adoptive immunotherapy for cancer. (springer.com)
- CAR comprises an extracellular, cancer-specific antibody fused with the intracellular signaling activation domains of CD3 and co-activation ligands, such as CD28 or 4-1BB [ 17 , 18 ], which provide engineered T cells with an MHC‐independent mechanism through which to kill cancer cells directly. (biomedcentral.com)
- Due to their MHC-independence, γδ T cells can be applied in cellular immunotherapy also across HLA barriers. (explorationpub.com)
Types1
- While still early days, immunotherapy promises to change the face of cancer treatment as more applications are found across various cancer types. (theusaknowledge.net)
Effects1
- Using surgically relevant preclinical animal models, Dr. Auer has identified candidate immunotherapies capable of counteracting the effects of surgery. (cancersummit.ca)
Natural1
- Natural killer cell adoptive immunotherapy: Coming of age. (springer.com)
Research3
- PA started her own research group in 1996 with a focus on mechanisms of cancer cell death induced by irradiation. (euroacadti.eu)
- Projects proposed should focus on establishing an efficient infrastructure to collect and analyze outcomes data of cellular immunotherapy trials (NCI-sponsored, investigator-initiated, or pharmaceutical company-sponsored) or with an FDA-approved agent and facilitating analysis of the observational data for the design of pre-clinical research in the Cancer Immunotherapy Consortium (CIC) and elsewhere, as well as inform design of future trials. (nih.gov)
- The CIC will be composed of organ site-specific Cancer Immunotherapy Research Projects (U01, supported by RFA-CA-17-045 ) and Cancer Immunoprevention Research Projects (U01, supported by RFA-CA-17-046 ). (nih.gov)
Potential1
- Thus, PRAME is a potential candidate for cancer immunotherapy because it is expressed by a variety of tumours and can induce T-cell immune responses. (pipelinereview.com)