• An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
  • It first binds with high affinity to specific cell-surface receptors and then induces their dimerization, which is essential for activating the tyrosine kinase in the receptor cytoplasmic domain, initiating a signal transduction that results in DNA synthesis and cell proliferation. (embl.de)
  • Cellular RNA methylation level can have profound impacts on normal cell differentiation and cancer cell proliferation. (chicagobiomedicalconsortium.org)
  • Mechanistically, EBF2 uniformly activates Pparγ-expression in pancreatic cancer cells and limits cell proliferation, whereas oncogenic drivers are expressed differentially in the progenitor cell subsets. (amegroups.org)
  • The complex PDAC pathobiology is established predominantly through KRAS mutations and the associated cellular signaling that contributes to cell proliferation and dedifferentiation ( 5 , 6 ). (amegroups.org)
  • Chronic B cell activation may drive proliferation of antigen-selected B cell clones that accumulate genetic lesions and ultimately undergo neoplastic transformation. (biomedcentral.com)
  • To enable future therapeutic efficacy, the survival, proliferation, migration and differentiation of neural stem/progenitor cells (NPCs) should be accurately studied and optimized in in vitro platforms before transplanting these cells into the body for treatment purposes. (sharif.edu)
  • Understanding the function of lectin-glycan recognition systems in cell death will facilitate the implementation of novel therapeutic strategies aimed at controlling unbalanced cell proliferation and survival in several pathologic conditions. (nature.com)
  • Effects of chloroplast DNA content on the cell proliferation and aging in Chlamydomonas reinhardtii. (bio.net)
  • Mesenchymal cells were isolated from periodontal ligament of impacted third molars (n=2) and cultured on titanium disks (polished and nitrided) and on a plastic surface as a positive control of cell proliferation. (bvsalud.org)
  • Cell proliferation was analyzed and growth curves were constructed for the different groups by determining the number of cells adhered to the different surfaces at 24, 48 and 72 h after plating. (bvsalud.org)
  • We concluded that plasma nitriding produced surfaces that permitted the proliferation of human periodontal ligament mesenchymal cells. (bvsalud.org)
  • Various biological events associated with bone healing on implant surfaces can be investigated separately using appropriate cell cultures, such as cell adhesion, proliferation and differentiation, as well as the production and mineralization of extracellular matrix. (bvsalud.org)
  • In this respect, this study evaluated the proliferation of mesenchymal cells derived from the periodontal ligament of human third molars on polished and plasma-nitrided titanium surfaces. (bvsalud.org)
  • Several genes involved in different aspects of stem cell activation are being studied, including some that transduce initial signals, and others that regulate self-renewal and differentiation. (chicagobiomedicalconsortium.org)
  • We are testing the hypothesis that specific transcription factors form regulatory networks to execute gene expression programs important for SSC fate decisions (self-renewal and differentiation), and ultimately, spermatogenesis. (utsa.edu)
  • Early lactation increases metabolic stress in ketotic dairy cows, leading to mitochondrial damage, apoptosis, and inflammatory response in mammary epithelial cells. (bvsalud.org)
  • The pyrin domain 3 (NLRP3) pathway involving the mitochondrial reactive oxygen species (Mito-ROS)-induced nucleotide-binding oligomerization domain-like receptor has been recognized as a key mechanism in this inflammatory response and cell apoptosis. (bvsalud.org)
  • This study aimed to elucidate the underlying regulatory mechanism of Mito-ROS-NLRP3 pathway-mediated mammary epithelial cell apoptosis in dairy cows with ketosis. (bvsalud.org)
  • However, NLRP3 inhibitor MCC950 pretreatment or Mito-ROS scavenging by MitoTEMPO attenuated apoptosis in FFA-induced MAC-T cells by inhibiting the NLRP3 inflammasome pathway. (bvsalud.org)
  • These findings reveal that the Mito-ROS-NLRP3 pathway activation is a potent mechanism underlying mammary epithelial cell apoptosis in response to metabolic stress in ketotic dairy cows, which further contributes to reduced milk yield. (bvsalud.org)
  • Several years later, Kerr and co-workers 2 defined the morphological changes in cells undergoing this process, also known as apoptosis. (nature.com)
  • We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)
  • The cytotoxic T lymphocytes (CTLs) typically express CD8 and induce apoptosis of cells on which they recognize foreign antigens presented by MHC class I molecules, providing a defense against intracellular pathogens such as viruses. (cdc.gov)
  • In previous reports, we identified a set of genes regulated by Hh signalling in ovarian tumour cells among which MMP-7 was identified as a potential Hh target gene candidate. (jcancer.org)
  • Expression of this gene throughout transgenic tobacco plants leads to excess numbers of multicellular trichomes on leaves and floral organs as well as the novel production of conical cells on leaves. (biologists.com)
  • The timing of MIXTA expression suggests that the choice between the cell types depends on the competence for cell division at the time at which the controlling gene is expressed. (biologists.com)
  • While GL1 and TTG control the commitment to trichome formation, the TRY gene product functions after cell commitment but before cell morphogenesis to limit the number of cells responding to the initial signal. (biologists.com)
  • thus, Pnn may affect crucial alternative splicing (AS) decisions and, in turn, impact cell-type specific gene expression. (molvis.org)
  • Molecular cloning and transcriptional mapping of the mouse cellular retinoic acid-binding protein gene. (ulaval.ca)
  • The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. (nih.gov)
  • Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. (nih.gov)
  • Here we show that the brown adipose differentiation gene, EBF2, activates differentiation-associated signals in the cancer progenitor cells in culture and CSC transplantation models. (amegroups.org)
  • Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. (nih.gov)
  • Mutations of PTCH1 gene in two pedigrees with bifid rib-basal cell nevus-jaw cyst syndrome. (nih.gov)
  • To this end, our specific objectives are to determine the nature and mechanism of action of both the general transcription initiation factors that are commonly used by all genes and the gene- and cell type-specific factors that directly regulate target genes in response to various growth, developmental and viral stimuli. (rockefeller.edu)
  • The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation. (bio.net)
  • Microarrays may be used to assay gene expression within a single sample or to compare gene expression in 2 different cell types or tissue samples, such as in healthy versus diseased tissue. (medscape.com)
  • Clear and concise, this easy-to-use book offers an introductory course on the language of gene cloning, covering microbial, plant, and mammalian systems. (lu.se)
  • It presents the nuts and bolts of gene cloning in a well-organized and accessible manner. (lu.se)
  • Part I of this book outlines the essentials of biology and genetics relevant to the concept of gene cloning. (lu.se)
  • Part II describes common techniques and approaches of gene cloning, ranging from the basic mechanics of DNA manipulation, vector systems, process transformation, to gene analysis. (lu.se)
  • The ABCs of Gene Cloning, Third Edition contains updates including a tutorial chapter on gene-vector construction, methodologies on exome sequencing in finding disease genes, revised topics on gene therapy and whole genome sequencing, new developments for gene targeting and genome editing, as well as the current state of next generation sequencing. (lu.se)
  • With more than 140 illustrations, this new edition provides an invaluable text for students and anyone who have interest in gaining proficiency in reading and speaking the language of gene cloning. (lu.se)
  • Structural and functional interaction of nucleic acids and proteins in the replication, transcription and translation of genetic material. (charlotte.edu)
  • Several complementary DNA clones encoding related HRGs were identified, all of which are similar to proteins in the epidermal growth factor family. (embl.de)
  • EGF-like domains in extracellular matrix proteins: localized signals for growth and differentiation? (embl.de)
  • Multidomain proteins of the extracellular matrix (ECM) play an important role in development and maintenance of cellular organization and in tissue repair. (embl.de)
  • Expression of B cell-stimulatory cytokines IL-1β, IL-6, IL-10, IL-12 p40 , IL-13 and TNFα and HIV proteins p17, gp120 and nef were elevated in the Tg mice with lymphoma. (biomedcentral.com)
  • Increased expression of HIV proteins and the B-cell stimulatory factors is consistent with the interpretation that one or more of these factors play a role in lymphoma development. (biomedcentral.com)
  • We demonstrate that recombinant LHCGR proteins which include the hormone-binding domain are secreted from transfected cells and that natural LHCGR is also secreted from human placental explants. (biomedcentral.com)
  • LHCGR recombinant proteins representing varying lengths of the N-terminal extracellular domain were expressed in Chinese Hamster Ovary cells in suspension culture. (biomedcentral.com)
  • Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
  • Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings. (nature.com)
  • At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
  • Specifically, cell-mediated responses typically focus on peptides from internal influenza proteins, which are far less susceptible to antigenic variation. (cdc.gov)
  • In contrast, T cells, which mediate cellular immune responses, can target internal proteins common to heterologous viral strains. (cdc.gov)
  • Students have the option to choose the Molecular, Cellular, and Developmental Biology (MCD) concentration or the Ecology, Evolution, and Environmental Biology (E3B) concentration but are not required. (charlotte.edu)
  • Advanced Cellular and Molecular Biology. (charlotte.edu)
  • A laboratory- oriented course designed to integrate plant molecular biology, recombinant DNA technology, and plant cell and tissue culture. (charlotte.edu)
  • E. Ladi's present address is Department of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720. (rupress.org)
  • After losing interest in molecular biology she decided to apply her knowledge of genetics to cellular biology, more specifically pattern formation and regeneration in the hydra, a genus of freshwater polyps. (wepapers.com)
  • Overall, when she began working in this lab with Wieschaus she discovered new ways of working on recombinant DNA and molecular biology with the focus to clone developmentally interesting genes. (wepapers.com)
  • A comprehensive toolbox of reporters for all subcellular structures is expected to transform our understanding of cell biology in tissues. (bvsalud.org)
  • The Hsieh laboratory is a neural stem cell biology laboratory that focuses on 4 major areas: (1) epilepsy-in-a-dish, (2) 3D cerebral organoids, (3) patient recruitment, and (4) mechanisms of adult neurogenesis. (utsa.edu)
  • Nature Structural & Molecular Biology, 13 (4). (lincoln.ac.uk)
  • Journal also covers a wide range of topics including synthetic biology and structural genomics. (stmjournals.com)
  • Reviews in Cell Biology and Molecular Medicine articles are self-contained treatments of a given topic, usually with over 100 references and 10 to 20 figures and tables, making this an authoritative reference source for undergraduate and graduate students, faculty, librarians and researchers. (lu.se)
  • A 45-kilodalton protein heregulin-alpha (HRG-alpha) that specifically induced phosphorylation of p185erbB2 was purified from the conditioned medium of a human breast tumor cell line. (embl.de)
  • Scatchard analysis of the binding of recombinant HRG to a breast tumor cell line expressing p185erbB2 showed a single high affinity binding site [dissociation constant (Kd) = 105 +/- 15 picomolar]. (embl.de)
  • We studied tumor cell signaling in the cell subsets to understand the tumor-inhibitory potentials of EBF2. (amegroups.org)
  • In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
  • In vivo, NM23-NDPKs regulate a diverse array of cellular events including growth and development. (embl.de)
  • The Goodell Lab focuses on the basic mechanisms that regulate hematopoietic stem (HSC) cells, and how their mis-regulation leads to leukemia development. (chicagobiomedicalconsortium.org)
  • Collectively, our study reveals that medullary TECs have the potential to differentiate into various types of molecularly distinct and functionally defined cells, which not only contribute to the induction of central tolerance, but also regulate the homeostasis of other thymus-resident populations. (bvsalud.org)
  • Here we investigated whether polarized monolayers of intestinal epithelial cells might regulate inflammatory responses by secreting IL-8 in a vectorial fashion (i.e. apical versus basolateral) depending on the location of the TLR stimulus. (biomedcentral.com)
  • Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)
  • [8] The evolutionary conservation of type I IFN subtypes binding the same IFNAR receptor at the same site with differing affinities suggests that type I IFNs are nonredundant and potentially regulate different cellular responses. (wikidoc.org)
  • Epithelial ovarian cancer is the major ovarian malignancy and comprises five histological subtypes: serous, mucinous, endometrioid, transitional and clear cell [ 3 , 4 ]. (jcancer.org)
  • Methods: Total RNA was isolated from PNN knockdown human corneal epithelial (HCET) cells or Pnn-deficient mouse corneas, and subjected to real-time-PCR (RT-PCR) assays, and the alternatively spliced lncRNAs were counted. (molvis.org)
  • Finally, in situ hybridization analyses revealed the presence of RP11-295G20.2 in the nuclei of corneal epithelial cells, but not in the stromal cells of the human cornea, while RP11-322M19.1 was present in epithelial and non-epithelial cells. (molvis.org)
  • Expression of EBF2 in the PDX1 and E-cadherin-expressing and organoid forming pancreatic epithelial CSCs indeed induced ductal and acinar-like structural differentiation in vivo in tumors resulting in tumor suppression. (amegroups.org)
  • Yap/Taz mutant lung epithelial cells undergo accelerated lamellar body maturation, a subcellular manifestation of their molecular defects. (bvsalud.org)
  • To this end, T cells undergo a very strict educational program in the thymus, during which both non-functional and self-reactive T cell clones are eliminated by means of positive and negative selection1.Thymic epithelial cells (TECs) have an indispensable role in these processes, and previous studies have shown the notable heterogeneity of these cells2-7. (bvsalud.org)
  • The CXCR1 receptor for IL-8 was expressed only on the apical membrane of Caco-2 BBE cells and differentiated epithelial cells in the human small intestine and colon. (biomedcentral.com)
  • These results show that IL-8 induces autocrine signalling via an apical CXCR1 in Caco-2 BBE intestinal epithelial cells and that this receptor is also expressed on the apical surface of differentiated human intestinal epithelial cells in vivo , suggesting an autocrine function for IL-8 secreted in the lumen. (biomedcentral.com)
  • Intestinal epithelial cells (IECs) play a key role in the inflammatory response to colonizing or invading microorganisms via the secretion of interleukin-8 (IL-8). (biomedcentral.com)
  • Interestingly, IL-8 has been measured in the colon milieu of healthy volunteers using a dialysis bag inserted in the rectum [ 9 ] suggesting that it might be apically secreted by colonic epithelial cells. (biomedcentral.com)
  • SM-AP1-3 cells were immunopositive for keratin only, indicating their duct-epithelial or squamous cell differentiation, while SM-AP4/5 cells were positive for both keratin and S-100 protein, indicating their myoepithelial cell differentiation. (biomedcentral.com)
  • The influenza A viruses infect host epithelial cells by attaching to a cellular receptor (sialic acid) by the viral surface protein hemagglutinin (HA). (cdc.gov)
  • and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
  • The earliest biochemical evidence on the existence of cell-free soluble LH receptor was the purification of an hCG-binding protein, relative molecular mass of 65K (M r , 65K) from porcine follicular fluid and was based on gel filtration followed by affinity chromatography [ 9 ]. (biomedcentral.com)
  • Transcriptome analyses revealed that Caco-2 BBE cells respond to stimulation with IL-8 supporting the hypothesis that IL-8 induces G protein-coupled receptor signalling. (biomedcentral.com)
  • In neutrophils, IL-8 binding to CXCR1 triggers G protein-coupled signalling and formation of second messengers that mediate cellular migration, exocytosis of effectors and a respiratory burst to facilitate oxygen-dependent killing of phagocytosed microorganisms [ 2 ]. (biomedcentral.com)
  • Protein phosphorylation regulates actomyosin-driven vesicle movement in cell extracts isolated from the green algae, Chara corallina. (bio.net)
  • The protein then switches to an active form when DNA damage is detected to trigger the process of cell self-destruction. (elifesciences.org)
  • The Reinberg lab studies the processes shaping chromatin structure and the transcriptional outcome establishing cellular identity. (chicagobiomedicalconsortium.org)
  • Here, using multiomic analysis, we provide further insights into the functional and developmental diversity of TECs in mice, and reveal a detailed atlas of the TEC compartment according to cell transcriptional states and chromatin landscapes. (bvsalud.org)
  • The He lab identified a core complex comprised of two subunits: METTL3 and METTL14, and an accessory factor WTAP, which mediates cellular m6A RNA methylation. (chicagobiomedicalconsortium.org)
  • Most of the general factors (classes II and III) have been purified and individual subunits cloned for further structural and functional studies. (rockefeller.edu)
  • IFNAR is a heteromeric cell surface receptor composed of two subunits, referred to as the low affinity subunit, IFNAR1 , and the high affinity subunit, IFNAR2 . (wikidoc.org)
  • Furthermore overexpression of both GABPβ and GABPα subunits in Cos1 cells led to increased endogenous CyP40 mRNA amounts. (techuniq.com)
  • Cells were transfected with the early B-cell factor-2 (EBF2) to activate progenitor cell differentiation and gauged the tumorigenic potentials of the derived cell subsets. (amegroups.org)
  • This study reveals a previously unrecognized function of EBF2 in regulating PDAC progenitor cell differentiation and tumor suppression. (amegroups.org)
  • Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
  • We discuss the rationale of various anti-fibrogenic treatment strategies targeting the clonal hematopoietic stem/progenitor cell, aberrant signaling pathways, fibrogenic cytokines, and the tumor microenvironment. (haematologica.org)
  • As NTPs, particularly GTP, are important for cellular macromolecular synthesis and signalling mechanisms, Ndk plays an important role in bacterial growth, signal transduction and pathogenicity. (embl.de)
  • We show that germline SBDS deficiency establishes a fitness constraint that drives selection of somatic clones via two distinct mechanisms with different clinical consequences. (nature.com)
  • Although studies have identified unique transcription factors in the selection of normal pancreatic lineages, the cells of origin and molecular mechanisms arbitrating PDAC growth are poorly defined. (amegroups.org)
  • Antigen-specific ligation of T-cell receptors induces effector mechanisms that either directly or indirectly promote lysis of infected cells. (cdc.gov)
  • Germ cells - from which egg cells and sperm cells develop - are particularly vulnerable as they contain sensitive quality control mechanisms that kill any cell that contain damaged DNA. (elifesciences.org)
  • Harnessing neural stem cells to repair neuronal damage is a promising potential treatment for neuronal diseases. (sharif.edu)
  • Axon is an important part of the neuronal cells and axonal microtubules are bundles in axons. (sharif.edu)
  • Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
  • Direct neuronal conversion of resident glial cells is advantageous since they are ubiquitously distributed brain cells able to self-renew and replenish their number, making them ideal candidates for endogenous repair. (lu.se)
  • Chimerism or Mosaicism: During development, the emergence of genetic mutations in an otherwise normal animal which create distinct lineages of mutant cells or clones. (mhmedical.com)
  • This is most obvious with the keratinocyte mutations that occur in utero during skin morphogenesis such that they are intermixed with normal cells. (mhmedical.com)
  • Here we report that multiple independent somatic hematopoietic clones arise early in life, most commonly harboring heterozygous mutations in EIF6 or TP53 . (nature.com)
  • Somatic TP53 mutations have been observed in patients with SDS who develop MDS 13 , raising the possibility that next-generation sequencing could be integrated into surveillance for somatic clones with enhanced leukemia potential. (nature.com)
  • The lab is investigating the role of DNA methyltransferase 3a (DNMT3A) in regulating stem cell function, and how mutations in DNMT3A lead to age-related clonal hematopoiesis and development of hematologic malignancies. (chicagobiomedicalconsortium.org)
  • Goodell reported that PPM1D mutations confer a survival advantage onto hematopoietic clones by rendering them resistant to DNA-damaging agents such as cisplatin, a cytotoxic chemotherapeutic. (chicagobiomedicalconsortium.org)
  • Recent studies have documented frequent evolution of clones carrying common cancer mutations in apparently normal tissues, which are implicated in cancer development1-3. (bvsalud.org)
  • Through whole-genome sequencing of single molecules of circulating cell-free DNA, we found that tumor-derived mutations in cancer genomes are associated with regions of late replication timing and other chromatin features. (cdc.gov)
  • Absent in melanoma (AIM)-like receptors (ALRs): myeloid cell nuclear differentiation antigen. (guidetopharmacology.org)
  • Glycosylation of classical death receptors fine-tunes cell death programs. (nature.com)
  • Barent et al 1998) the possibility remains that this relative cellular abundance of the immunophilins is usually a key determinant of immunophilin-receptor association in vivo. (techuniq.com)
  • The functional and structural adhesion of bone tissue to the surface of load-bearing orthopedic implants seems to be a determinant factor for in vivo success 2 . (bvsalud.org)
  • 3 Myelofibrosis (MF) refers to the Philadelphia chromosome ( BCR-ABL1 )-negative myeloproliferative neoplasm (MPN) originating at the level of the multipotent hematopoietic stem cell. (haematologica.org)
  • Chromosome analyses showed numeral abnormalities such as 5n ploidies and various kinds of structural abnormalities, such as deletions, translocations, derivatives and isodicentric chromosomes. (biomedcentral.com)
  • It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
  • 10 Galectins can function inside the cells by modulating signaling pathways, 11 although they also act extracellularly by establishing multivalent interactions with cell surface glycans and delivering signals that lead to disruption of cellular homeostasis. (nature.com)
  • Heregulin transcripts were identified in several normal tissues and cancer cell lines. (embl.de)
  • Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents. (mcmaster.ca)
  • Zhang H, Wang Y, Chen T, Zhang Y, Xu R, Wang W, Cheng M, Chen Q. Aberrant Activation Of Hedgehog Signalling Promotes Cell Migration And Invasion Via Matrix Metalloproteinase-7 In Ovarian Cancer Cells. (jcancer.org)
  • Matrix metalloproteinase-7 (MMP-7) facilitates degradation of the extracellular matrix, promoting the invasion of tumour cells, and is associated with cancer progression and metastasis. (jcancer.org)
  • MMP-7 facilitated the invasion and migration of ovarian tumour cells, indicating its key function in ovarian cancer progression. (jcancer.org)
  • Cancer stem cells (CSCs) and poorly differentiated progenitor cells in pancreatic ductal adenocarcinoma (PDAC) exacerbate hierarchical tissue organization contributing to cell hyperproliferation and therapy resistance. (amegroups.org)
  • Cervical cancer is the uncontrollable division of cells in the cervix, or lower part of the uterus. (asu.edu)
  • T lymphocytes for adoptive cell therapy against hematological cancer. (upstate.edu)
  • This approach set the basis for therapeutic strategies aimed at eliminating aberrantly glycosylated cancer cells. (nature.com)
  • immunotherapeutics being a prime example of the latter) with the potential to eliminate all cancer cells, despite their clonal heterogeneity and their surrounding microenvironment. (nih.gov)
  • The irradiation and chemotherapy drugs that are used to destroy cancer cells also damage healthy cells. (elifesciences.org)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
  • Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
  • The tumor cells are clonal and characterized by an increased expression of several cellular oncogenes. (biomedcentral.com)
  • The transformed B cell population consists of CD19 + pre-BCR + CD127 + CD43 + CD93 + precursor B cells and are clonal. (biomedcentral.com)
  • FKBP51 displays an increased temporal pattern of expression during the early clonal growth phase of adipocyte differentiation (Yeh et al 1995) and it is up-regulated by glucocorticoids (Baughman et al. (techuniq.com)
  • The least-differentiated cells are the totipotent embryonic stem cells which can develop into any cell in the body. (mhmedical.com)
  • In 2014, an innovative study by Leslie et al [7] used human intestinal organoids (HOIs) derived from stem cells to model the disruption of barrier functions in the human intestine by CD. (listlabs.com)
  • Student projects in my lab will revolve around cell-fate decisions in Spermatogonial Stem Cells (SSC). (utsa.edu)
  • SSCs are adult-tissue stem cells in the mammalian testis that balance self renewing and differentiating fate decisions to give rise to and sustain the entire spermatogenic lineage. (utsa.edu)
  • Despite initial therapeutic outcomes, conventional stem cells face key limitations. (biomedcentral.com)
  • The novel Cymerus™ manufacturing facilitates production of a virtually limitless supply of consistent human induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells, which could play a key role in selective immunosuppression and graft repair during rejection. (biomedcentral.com)
  • These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)
  • First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
  • Additionally, the truncated Lhcgr, misrouted the full-length Lhcgr in ER, thereby decreasing the cell surface expression of the mature functional receptor. (biomedcentral.com)
  • The availability of large quantities of highly purified enzyme makes it now possible to investigate the spectroscopic, mechanistic, functional, and structural properties of this human enzyme at the molecular level. (rhea-db.org)
  • The emergence of functional studies on animal lectins during the 1990s has provided the appropriate framework to better understand their roles in cell death. (nature.com)
  • Provides the main structural substance (collagen) of skin. (mhmedical.com)
  • BALB/c → C57BL/6 allografts were reconstituted with iPSC-derived MSCs (2 million/transplant/at d0), and allografts were examined for regulatory T cells (Tregs), oxygenation, microvascular blood flow, airway epithelium, and collagen deposition during rejection. (biomedcentral.com)
  • The evidence for an autoimmune etiology includes pathological findings of infiltrating T cells, the presence of antigen-antibody complexes in affected cartilage, cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive regimens most often suppress the disease. (medscape.com)
  • Today, clinical trials using stem cell-derived dopaminergic progenitors have commenced. (lu.se)
  • Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)
  • The hormonal activation occurs through specific ligand-receptor interactions on the surface of the target cells. (biomedcentral.com)
  • The CD4+ T helper cells are primarily responsible for helping other immune cells through direct cell-cell interactions or by secreting cytokines after recognizing viral peptides bound to major histocompatibility complex (MHC) class II molecules. (cdc.gov)
  • During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
  • Transplanted cells in nude mice formed subcutaneous tumors, which had histological features of squamous cell carcinoma with apparent keratinizing tendencies. (biomedcentral.com)
  • The histological features of squamous cell carcinoma from the transplanted cell systems in nude mice might suggest a secondary onset of malignancy from a pre-existing benign adenoma. (biomedcentral.com)
  • IFNAR1 is the low affinity subunit, originally cloned in 1990, and is composed of four fibronectin type II-like (FNII-like) subdomains, termed SD1-4. (wikidoc.org)
  • 2014) Purification, characterization and docking studies of the HIN domain of human myeloid nuclear differentiation antigen (MNDA). (guidetopharmacology.org)
  • Here we report a phenotypic and molecular characterization of B cell tumors that develop in Tg26 mice. (biomedcentral.com)
  • Cloning and characterization of an active fragment of luciferase from a luminescent marine alga, Pyrocystis lunula. (bio.net)
  • Cellular immunology, T cell immunity, autoimmune diseases: The immune system plays a fundamental role in the defense against microbial pathogens. (utsa.edu)
  • We discuss the advantages of developing a vaccine based on cell-mediated immune responses toward highly pathogenic influenza virus and potential problems arising from immune pressure. (cdc.gov)
  • This property gives vaccines that induce protective cellular immune responses the potential to protect against heterologous viral strains. (cdc.gov)
  • Greater understanding of how each subset contributes to protective immunity and how T-cell memory is maintained and recalled in a secondary infection would contribute to development of effective vaccines that use these basic features of the immune response. (cdc.gov)
  • In particular, the T-cell immune response to influenza infection has been well characterized in C57BL/6 (B6,H2 b ) mice. (cdc.gov)
  • While influenza infection of mice does not precisely replicate the natural infection in human, avian, or other vertebrate species, the availability of reagents and genetically modified mouse models has enabled extensive analysis of the cellular immune response. (cdc.gov)
  • As a unique transcription factor in plants, HD-Zip plays an important regulatory role in plant growth and development, environmental response, cell cycle and cell metabolism [ 9 ]. (biomedcentral.com)
  • The tumor-promoting signals such as Akt-phosphorylation, β-catenin, and c-Myc were upregulated in the cells compared to the controls. (amegroups.org)
  • Endogenous lectins and glycans are critical signals in the resolution of cell death. (nature.com)
  • MNDA is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family ( HGNC family 995 ). (guidetopharmacology.org)
  • Duplication of genes and their association with different cis -regulatory regions may therefore result in the specification of novel plant cell types. (biologists.com)
  • The processes of animal cell growth, differentiation and infection by viruses result from the differential expression of specific genes, controlled primarily at the level of transcription. (rockefeller.edu)
  • Similarly, the transcription of small structural RNA genes (5S RNA, tRNA) by RNA polymerase III involves the assembly of common factors (TFIIIC and TFIIIB) into highly stable complexes via an ordered pathway. (rockefeller.edu)
  • check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)
  • These results mechanistically link leukemia predisposition to germline genetic constraints on cellular fitness, and provide a rational framework for clinical surveillance strategies. (nature.com)
  • We review the literature on the role of CD4+ and CD8+ T cell-mediated immunity in influenza infection and the available data on the role of these responses in protection from highly pathogenic influenza infection. (cdc.gov)
  • A different experimental approach by West and Cooke [ 10 ] demonstrated the secretion of M r 80-90K hCG-LH receptor complex into the culture media from ligand-induced rat and mouse leydig cells. (biomedcentral.com)
  • 11 ] first reported the production and secretion of soluble LH receptor following transient transfection of a naturally truncated variant of the receptor in COS cells. (biomedcentral.com)
  • Moreover, the lack of a secreted form of the receptor was overcome by co-expression of hCG with the extra-cellular domain of porcine LH receptor leading to the secretion of a mixture of free as well as hCG-receptor complex [ 13 ]. (biomedcentral.com)
  • instead, a specific intra-cellular role of truncated receptor in regulating the cell surface expression of a full-length ligand-binding Lhcgr has been proposed [ 15 ]. (biomedcentral.com)
  • Additionally, we determined the localization of the CXCR1 receptor in Caco-2 BBE cells and human intestinal tissue samples and investigated the role of IL-8 autocrine signalling using transcriptomics. (biomedcentral.com)
  • Structural analysis of type I IFN receptor with different type I IFN ligand subtypes revealed a similar binding site for the different agonists. (wikidoc.org)
  • Clone: Any distinct cell and all of its progeny. (mhmedical.com)
  • Blaschko Lines: The migration pattern of skin cells during embryonic development can be visualized in adults if that individual is a chimera and a distinct clone has a clinical abnormality such that it is visible in the background of other skin cells. (mhmedical.com)
  • Plants are considered to be anatomically simple and composed of relatively few morphologically distinct cell types ( Goldberg, 1988 ). (biologists.com)
  • Functionally distinct T-cell subsets are broadly identified according to their differential expression of CD4 and CD8 coreceptors. (cdc.gov)
  • Hematopoietic stem cell transplantation remains the only curative therapeutic approach that reliably results in resolution of bone marrow fibrosis in patients with myelofibrosis. (haematologica.org)
  • This laboratory pursues several lines of investigation to understand how T cells contribute to autoimmune diseases and protection from infection, and how to modulate T cell immunity for therapeutic purposes in humans. (utsa.edu)
  • Nucleoside diphosphate kinase: role in bacterial growth, virulence, cell signalling and polysaccharide synthesis. (embl.de)
  • We isolated CSCs from low passage PDAC cell lines derived from human tumors and commercially available cell lines. (amegroups.org)
  • This study demonstrates in vitro that certain cell types from pleomorphic adenoma are able to clone and survive over a long term and develop subcutaneous tumors in nude mice. (biomedcentral.com)
  • The expected subcellular compartments are labeled in culture and in tissues with no impact on cellular and organismal viability. (bvsalud.org)
  • Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death. (nature.com)
  • The enzyme possesses enzymatic activities such as transamidation/crosslinking and non-enzymatic functions such as cell migration and signal transduction. (sharif.edu)
  • Several surface treatments were developed to improve the molecular and cellular events that guide the early stages of this process 3 . (bvsalud.org)
  • Mitochondrial damage and cellular apoptotic program and NLRP3 inflammasome activation were observed in the mammary gland of ketotic cows. (bvsalud.org)
  • Activation follows a spring-loaded mechanism not requiring further translation of other cellular factors in oocytes and is associated with unfolding of the inhibitory structure that blocks the tetramerization interface. (elifesciences.org)
  • This association of phenotype and function is not absolute, since CD4+ cells may exhibit lytic activity, while CD8+ cells secrete antiviral cytokines, notably interferon-γ (IFN-γ) and tumor necrosis factor. (cdc.gov)
  • T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)
  • However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. (cdc.gov)
  • The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)
  • In addition, they had ductal arrangements or plasmacytoid appearances of tumor cells and myxoid or hyaline stromata, indicating some characteristics of pleomorphic adenoma. (biomedcentral.com)
  • Human Immunodeficiency Virus Type I (HIV-1) infection is associated with a high incidence of B-cell lymphomas. (biomedcentral.com)
  • Human Immunodeficiency Virus Type I (HIV-1) infection is associated with an elevated incidence of B-cell non-Hodgkin's lymphoma (NHL) and in recent years also with Hodgkin's lymphoma [ 1 ]. (biomedcentral.com)
  • Quantitative and live imaging of the tricolor reporter captures cell type-specific organelle features and kinetics in the lung, as well as their changes after Sendai virus infection. (bvsalud.org)
  • Vaccine approaches against respiratory virus infections such as influenza have relied on inducing antibodies that protect against viral infection by neutralizing virions or blocking the virus's entry into cells. (cdc.gov)
  • Their real-time microelectronic sensor-based analysis had high sensitivity and relied on reading the impedance of cells applied to microelectrodes to detect specific cellular processes through quantification over time. (listlabs.com)
  • Dr. Jacobs described Vaccinia viruses deficient in E3L, a regulator of the cellular antiviral response and noted their potential for the production of improved vaccines. (cdc.gov)
  • MNDA can be detected exclusively in nuclei of hematopoietic cells of the monocyte lineage. (guidetopharmacology.org)
  • Cell lineage: The family tree history of a cell through all of its divisions. (mhmedical.com)
  • Differentiation: The process where a cell becomes increasingly specialized in their cellular lineage. (mhmedical.com)
  • EIF6 inactivation mediates a compensatory pathway with limited leukemic potential by ameliorating the underlying SDS ribosome defect and enhancing clone fitness. (nature.com)
  • These data indicate that conical cells and trichomes are produced by a common developmental pathway. (biologists.com)
  • 1992) Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. (guidetopharmacology.org)
  • This course integrates information into the context of regulation of cellular function. (charlotte.edu)
  • Here we describe the phenotypic and molecular characteristics of the B cell leukemia/lymphoma in the Tg mice. (biomedcentral.com)
  • To evaluate the proliferative capacity of mesenchymal cells derived from human periodontal ligament on polished and plasma-treated titanium surfaces. (bvsalud.org)
  • Periodontal ligament mesenchymal cells were obtained from two healthy human teeth (impacted third molars). (bvsalud.org)