Cellular differentiation cellular junctions cell cycle. Medical search. Frequent questions

It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. (cancerindex.org)

Even though its sequence along with its expressional pattern in cancer cell lines are evident, the functional aspects concerning cell proliferation, viability, differentiation and cell cycle regulation of NDRG1 remains vague. (scirp.org)
Unpredictably, cell cycle progression, cell proliferation and DNA synthesis were unaffected fol lowing NDRG1 expression. (scirp.org)
T. Napso, N. Azzam, A. Lerner and F. Fares, " N-myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 568-574. (scirp.org)
Cancer is a widespread and incurable disease caused by genetic mutations, leading to uncontrolled cell proliferation and metastasis. (bvsalud.org)
Uncontrolled cell proliferation leads to increased risk of genetic instability. (asspub.ro)
During the course of folliculogenesis, growth is achieved by cell proliferation and formation of follicular fluid, whereas development involves cytodifferentiation of all the cells and tissues in the follicle. (glowm.com)
Mechanistically, EBF2 uniformly activates Pparγ-expression in pancreatic cancer cells and limits cell proliferation, whereas oncogenic drivers are expressed differentially in the progenitor cell subsets. (amegroups.org)
The complex PDAC pathobiology is established predominantly through KRAS mutations and the associated cellular signaling that contributes to cell proliferation and dedifferentiation ( 5 , 6 ). (amegroups.org)
A hypoxic cell model prepared with CoCl 2 was developed to detect the effect of hypoxia on the proliferation and apoptosis of renal stem cells. (bjbms.org)
The effect and molecular mechanism of hypoxia-inducible factor 1-alpha (HIF-1α) on the proliferation and apoptosis of renal stem cells were also explored. (bjbms.org)
Both hypoxia and HIF-1α significantly promoted the proliferation of renal stem cells and inhibited cell apoptosis. (bjbms.org)
Liu H, Liu C, Qu Y. The effect and molecular mechanism of hypoxia on proliferation and apoptosis of CD133+ renal stem cells. (bjbms.org)
Serotonergic neurotransmission modulates cell proliferation in several tissues, but is involved mainly in the morphogenesis of the craniofacial region 8 . (bvsalud.org)
Extensive renovation of the epithelium, cell proliferation, apoptosis and changes in the shape and positioning of cell groups are determined by morphogenetic gradients that play critical roles during the morphogenesis of teeth 13 . (bvsalud.org)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)

The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. (bio2009.org)
Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. (asspub.ro)
Only a few follicles in the human ovary survive to complete the cytodifferentiation process, with 99.9% dying by a programmed cell death mechanism called apoptosis. (glowm.com)
Further, AMP-17 treatment resulted in an increase in reactive oxygen species (ROS) levels, depolarization of the mitochondrial membrane potential (MMP), and changes in the cell cycle, leading to the apoptosis and necrosis, which ultimately contributed to the death of C. albicans cells. (researchsquare.com)
Renal stem cells inhibited apoptosis and improved damaged local microenvironment through intrinsic paracrine effects, thereby contributing to the repair and regeneration of renal tissue injury. (bjbms.org)

This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherens junctions, as well as in the control of beta-catenin signaling. (wikipedia.org)
The binding of S1P leads to angiogenesis and tumor cell motility in cancer, and this interaction also participates in the formation of cell-cell adherens junctions. (prosci-inc.com)

The structure, regulation, and cell types of the mouse testis. (jci.org)
combine live imaging of the mouse epidermis and machine learning to study the role and regulation of calcium signaling within the stem cell layer. (silverchair.com)

IL-21 regulates Th17 cell homeostasis enhances the differentiation of storage B cells and antibody-secreting plasma cells and promotes the maintenance of Compact disc8+ T-cell replies. (bio2009.org)
Immunoreceptor signaling during development, homeostasis, and effector function of T cells and NK cells. (upstate.edu)
The multi‑dimensional nature of their roles in cellular homeostasis, cell‑to‑cell and tissue‑to‑tissue communication at the level of the organism, as well as their actions on the holobiome (intra‑/interspecies interaction), have garnered the interest of a large number of researchers. (spandidos-publications.com)
The profound roles of exosomes in homeostasis, stress and several pathological conditions, in conjunction with their selective and cell‑specific composition/function, allude to their use as promising circulating clinical biomarkers of systemic stress and specific pathologic states, and as biocompatible vehicles of therapeutic cargo. (spandidos-publications.com)
Exosomes, via their cargo or surface composition, are signals/mediators of systemic homeostasis and stress for specific cell-to-cell or tissue-to-tissue communication ( 5 ). (spandidos-publications.com)

In this Review, we briefly outline the roles that follicle-stimulating hormone (FSH) and testosterone play in regulating spermatogenesis and describe our current understanding of how vitamin A regulates germ cell differentiation and how it may lead to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave. (jci.org)
However, a major unresolved question is how each cell regulates the precise number of its motile cilia during differentiation. (elifesciences.org)
CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation. (nagoya-u.ac.jp)

These results revealed that NDRG1 is functional in prostate cancer cells and able to induce expression of differentiation factors through p53 independent pathway. (scirp.org)
However, the pathway downstream NDRG1, involving p21 and c8/18, regulating cell cycle progression and DNA synthesis is unfunctional. (scirp.org)
More recently, increased expression of NOTCH pathway genes was implicated in some DIPGs and NOTCH path inhibition contributed to reduced tumor growth in culture 14 , but the specificity of these treatments for H3.3 mutant cells remains unclear. (nature.com)
H3.3 mutant cells exhibited significant sensitivity to NOTCH pathway inhibition and knockdown, resulting in decreased cell viability under treatment. (nature.com)
Once spermatogonia enter the "differentiation" pathway, they become known as A1 spermatogonia in the mouse and A- pale spermatogonia in humans and begin a series of irreversible differentiation steps leading to meiosis and spermiogenesis ( 1 ) (Figure 1 ). (jci.org)
The neutrophil maturation and differentiation pathway termed myelopoiesis takes approximately 12 days. (medscape.com)

The extracellular region contains three Ig-like domains, and nine non-Ig-like domains similar to those of the neural cell adhesion molecule. (wikipedia.org)
Exosomes are small lipid bilayer-surrounded extracellular vesicles released from cells into the extracellular space or biological fluids ( 1 , 2 ). (spandidos-publications.com)
elevation, while cation channel blockers, free radical scavengers, low extracellular [Ca2+], transition metal chelators, and removal of the cell wall inhibit this reaction. (deepdyve.com)
However, this hypothesis began to be questioned when it was found that (i) acrosome-reacted sperm cells are still able to pass through extracellular layers and fertilize the oocyte (ii) most of the sperm cells undergo premature acrosomal reaction before they reach the oocyte. (nusl.cz)

The pathways involved in cellular differentiation or transformation are Smad, Rho proteins, and PI3-kinase. (molvis.org)
Here we describe a microscope based on light-sheet illumination 2 that allows massively parallel fluorescence correlation spectroscopy (FCS) 3 measurements and use it to visualize the diffusion and interactions of proteins in mammalian cells and in isolated fly tissue. (nature.com)
Transcripts found in unfertilized oocytes also encoded a large number of proteins implicated in cell adherence, tight junction and focal adhesion, suggesting high complexity in terms of structure and cellular interactions in embryos prior to midblastula transition (MBT). (biomedcentral.com)
The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
We investigated the presence and location of the six myosin proteins throughout the life cycle, by adding a C‐terminal GFP tag to each via single homologous recombination at the corresponding myosin gene locus. (pberghei.eu)
Therefore, we aimed to characterize proteomes of the acrosome and acrosome- reacted sperm cells, identify important proteins using advanced bioinformatics approaches and discuss the function of the acrosome as a vesicle that serves to store and process metabolites after the previous maturation process. (nusl.cz)

Early progenitor cells, which are designated A spermatogonia in the mouse and A- dark spermatogonia in humans, are defined as "undifferentiated. (jci.org)
Undifferentiated spermatogonia divide mitotically to both repopulate the testicular stem cell population and provide progenitor cells that undergo spermatogenesis. (jci.org)
Airway progenitor cells contain two parental centrioles (PC) and form structures called deuterosomes that nucleate centrioles during amplification. (elifesciences.org)
Cancer stem cells (CSCs) and poorly differentiated progenitor cells in pancreatic ductal adenocarcinoma (PDAC) exacerbate hierarchical tissue organization contributing to cell hyperproliferation and therapy resistance. (amegroups.org)
Here we show that the brown adipose differentiation gene, EBF2, activates differentiation-associated signals in the cancer progenitor cells in culture and CSC transplantation models. (amegroups.org)

Lung cDC2s from CD109-/- mice had a poor ability to induce cytokine production in ex vivo DC-T cell cocultures with high expression of RUNX3, resulting in suppression of Th2 differentiation. (nagoya-u.ac.jp)

The Drosophila follicle-cell epithelium provides an appropriate model system for studying the potential role of electrochemical signals, like intracellular pH (pH i ) and membrane potential (V mem ), during development. (biomedcentral.com)
Our data show that in the Drosophila follicle-cell epithelium stage-specific pH i - and V mem -gradients develop which result from the activity of several ion-transport mechanisms. (biomedcentral.com)
These changes over time and distance are designated the cycle of the seminiferous epithelium and the spermatogenic wave, respectively. (jci.org)
The virus infects basal epithelial cells of stratified squamous epithelium. (asspub.ro)
Schematic representation of the HPV double-stranded circular DNA genome Journal of Virology Nov HPV integration into the host genome and Papillomavirus life cycle To establish infection, the virus must infect cervical cancer without high risk hpv epithelial cells of stratified squamous epithelium, that are long lived or have stem cell-like properties. (asspub.ro)
Once inside the host cell, HPV DNA replicates as the basal cells differentiate and progress to the surface of the epithelium. (ghise-ioan.ro)
In vitro differentiation of small intestinal epithelium that approaches physiologic functionality of the in vivo host may allow for the development of a pathogenesis model for norovirus. (cdc.gov)
Representative models of differentiated human intestinal epithelium can be established by growing cells in 3 dimensions (3-D) on collagen-I-coated porous microcarrier beads in rotating-wall vessel (RWV) bioreactors that model the physiologic fluid-shear environment in their respective organs ( 21 - 24 ). (cdc.gov)

This resulted in over-expression of NDRG1, which in turn markedly up regulated two differentiation markers of the prostate tissue, p21 and cytokeratin 8/18. (scirp.org)
The number of mitochondria in a cell can vary widely by organism , tissue , and cell type. (wikipedia.org)
Endocrinology, by definition, focuses on homeostatic, and cell‑to‑cell and tissue‑to‑tissue communication mechanisms. (spandidos-publications.com)
My lab integrates traditional and single-nuclei RNA sequencing to elucidate transcriptome-wide changes to RNA metabolism in clinically relevant post-mortem brain tissue and human induced pluripotent stem cell (hiPSC) models of neurological disease including ALS and autism. (ed.ac.uk)
Local Ca 2+ signaling is organized across the tissue in a global manner and is regulated by cell cycle and connexin 43. (silverchair.com)
Goranci-Buzhala and Niessen highlight work from Moore and colleagues that uses high-resolution imaging and machine learning to examine tissue-scale patterns of Ca 2+ signaling by basal stem cells of the skin epidermis. (silverchair.com)
They find that cells in G2 are necessary for coordinated tissue-wide communication and reveal a feedback loop between cell cycle and calcium signaling. (silverchair.com)
However, it is not known if CXCR1 is expressed on the apical or basolateral poles in polarized Caco-2 BBE cells or human intestinal tissue or whether the direction of TLR signalling influences the direction of IL-8 secretion. (biomedcentral.com)
Additionally, we determined the localization of the CXCR1 receptor in Caco-2 BBE cells and human intestinal tissue samples and investigated the role of IL-8 autocrine signalling using transcriptomics. (biomedcentral.com)
Previous studies showed that renal stem cells can be directly induced into renal tubular epithelial cells to repair damaged tissue structures. (bjbms.org)

Imaging the mobility of heterochromatin protein HP1α (ref. 4 ) in cell nuclei we could provide high-resolution diffusion maps that reveal euchromatin areas with heterochromatin-like HP1α-chromatin interactions. (nature.com)
Figure 2: 1D- and 2D-FCS imaging of protein diffusion in Madin-Darby canine kidney (MDCK) cells. (nature.com)
Slaughter, B.D., Schwartz, J.W. & Li, R. Mapping dynamic protein interactions in MAP kinase signaling using live-cell fluorescence fluctuation spectroscopy and imaging. (nature.com)
Among the top ten genes preferentially enriched in these cells, Foxc2 was the only one to code for a protein exclusively present in the nucleus of uSPGs that also expressed ZBTB16, a protein important for SSCs to self-renew. (elifesciences.org)
EDG1 (Endothelial differentiation gene 1), also called Sphingosine-1-phosphate receptor 1 (S1PR1) is the G-protein coupled receptor for Sphingosine 1-phosphate (S1P). (prosci-inc.com)
We used live cell imaging to detect expression of each protein throughout the life cycle and to examine their location. (pberghei.eu)
also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). (cancerindex.org)
and keywords Abstract and keywords The ubiquitin-proteasome system (UPS) is a tightly and specifically regulated system of protein degradation in eukaryotic cells. (nusl.cz)
I found out that CBU79 probably decreases levels of protein synthesis by triggering cellular signalling via the unfolded protein response (UPR). (nusl.cz)
Transcriptome analyses revealed that Caco-2 BBE cells respond to stimulation with IL-8 supporting the hypothesis that IL-8 induces G protein-coupled receptor signalling. (biomedcentral.com)
In neutrophils, IL-8 binding to CXCR1 triggers G protein-coupled signalling and formation of second messengers that mediate cellular migration, exocytosis of effectors and a respiratory burst to facilitate oxygen-dependent killing of phagocytosed microorganisms [ 2 ]. (biomedcentral.com)

In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
Here we show that cell differentiation suppresses tumor formation. (amegroups.org)
We studied tumor cell signaling in the cell subsets to understand the tumor-inhibitory potentials of EBF2. (amegroups.org)
Expression of EBF2 in the PDX1 and E-cadherin-expressing and organoid forming pancreatic epithelial CSCs indeed induced ductal and acinar-like structural differentiation in vivo in tumors resulting in tumor suppression. (amegroups.org)
In contrast, Akt-phosphorylation, β-catenin, and c-Myc are repressed in the cells, presumably inhibiting tumor growth. (amegroups.org)
The tumor-promoting signals such as Akt-phosphorylation, β-catenin, and c-Myc were upregulated in the cells compared to the controls. (amegroups.org)
This study reveals a previously unrecognized function of EBF2 in regulating PDAC progenitor cell differentiation and tumor suppression. (amegroups.org)
In addition to inhibiting pathogens such as bacteria and fungi, AMPs also have varying degrees of killing effects on viruses, tumor cells, and parasites (Falanga et al. (researchsquare.com)

PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. (wikipedia.org)
[10] Mitochondrial biogenesis is in turn temporally coordinated with these cellular processes. (wikipedia.org)
Diffusion processes and local dynamic equilibria inside cells lead to nonuniform spatial distributions of molecules, which are essential for processes such as nuclear organization and signaling in cell division, differentiation and migration 1 . (nature.com)
We expect that FCS imaging will become a useful method for the precise characterization of cellular reaction-diffusion processes. (nature.com)
Moreover, increasing number of studies have highlighted the fact that a multifaceted approach from various domains of science such as biomechanics, cell biology, bioengineering, biophysics, biomaterials, computational modelling, endocrinology, and orthopaedics is essential to further our understanding of the intricate processes involved in bone remodelling and the central role of osteocytes in maintaining bone mass and architecture. (pharmaceuticalintelligence.com)
Via its interaction with S1P, EDG1 is involved in a number of cellular processes. (prosci-inc.com)

Here we investigated whether polarized monolayers of intestinal epithelial cells might regulate inflammatory responses by secreting IL-8 in a vectorial fashion (i.e. apical versus basolateral) depending on the location of the TLR stimulus. (biomedcentral.com)
The CXCR1 receptor for IL-8 was expressed only on the apical membrane of Caco-2 BBE cells and differentiated epithelial cells in the human small intestine and colon. (biomedcentral.com)
These results show that IL-8 induces autocrine signalling via an apical CXCR1 in Caco-2 BBE intestinal epithelial cells and that this receptor is also expressed on the apical surface of differentiated human intestinal epithelial cells in vivo , suggesting an autocrine function for IL-8 secreted in the lumen. (biomedcentral.com)
Intestinal epithelial cells (IECs) play a key role in the inflammatory response to colonizing or invading microorganisms via the secretion of interleukin-8 (IL-8). (biomedcentral.com)
Interestingly, IL-8 has been measured in the colon milieu of healthy volunteers using a dialysis bag inserted in the rectum [ 9 ] suggesting that it might be apically secreted by colonic epithelial cells. (biomedcentral.com)
CD133 + renal cells were also implanted into mice with acute kidney injury caused by glycerol, which revealed that renal-derived CD133 + cells differentiate into renal tubular epithelial cells at different injury sites. (bjbms.org)
Studies of viral attachment to cultured gastrointestinal epithelial cells (Caco-2) using recombinant virus-like particles or infectious noroviruses indicate that specific histo-blood group antigens play a key role in the attachment of the virus to the host cells ( 13 - 17 ). (cdc.gov)

Alterations of bioelectrical properties of cells and tissues are known to function as wide-ranging signals during development, regeneration and wound-healing in several species. (biomedcentral.com)
When the hosts are infected or subject to immune stimulation, AMPs can be quickly synthesized in some tissues and cells. (researchsquare.com)
Cells grown on porous collage-coated beads under fluid shear conditions in rotating wall vessel bioreactors differentiate into 3-D architectures resembling both the morphologic and physiologic function of in vivo tissues. (cdc.gov)

The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
5-HT interacts with its receptors, which alters cell metabolism and influences several stages of organogenesis 7 . (bvsalud.org)

Our results demonstrate that a cell-intrinsic surface area-dependent mechanism controls centriole and cilia abundance in multiciliated cells. (elifesciences.org)
They are derived by a targeted mechanism from the cell endocytic compartment and are formed and stored within the intracellular multivesicular bodies (MVBs). (spandidos-publications.com)
Taken together, this study clarified the effect of age on the content of human renal stem cells and determined the regulatory mechanism of hypoxia on renal stem cells. (bjbms.org)
However, the mechanism of renal stem cells in the repair of acute kidney impairment remains unclear. (bjbms.org)

N-myc downstream regulated gene 1 (NDRG1), also known as differentiation related gene 1, was previously identified as an up - regulated gene upon cellular differentiation. (scirp.org)
A Novel Gene Which Is Up-Regulated during Colon Epithelial Cell Differentiation and Down-Regulated in Colorectal Neoplasms," Laboratory Investigation: A Journal of Technical Methods and Pathology, Vol. 77, No. 1, 1997, pp. 85-92. (scirp.org)
Here we report successful gene editing of H3.3K27M and G34R point mutations in human normal brain and pediatric glioma cells, generating pairs of otherwise isogenic cell lines that allowed us to define epigenetic and transcriptomic changes contributing to gliomagenesis in the native genomic context. (nature.com)
Taken together, our findings suggest striking overlap between putative mechanisms of K27M and G34R mutations and point to increased NOTCH signaling playing a key role in K27M-related gliomagenesis, resulting from aberrant gene derepression due to impaired H3K27me3 deposition at super-enhancers in H3.3 mutant cells. (nature.com)
To study the transformative effects of oncohistone mutations in human pediatric gliomas in an otherwise isogenic context, we used CRISPR-Cas9 gene editing to revert H3.3K27M mutations in glioma cells back to wild type (WT) while in parallel introducing H3.3K27M and G34R point mutations into human astrocytes and H3.3WT glioma cells (Fig. 1a ). (nature.com)

Furthermore treatment with IL-21 elevated the in vivo degrees of Th17 cells in SIV-infected RMs. (bio2009.org)

Nature Cell Biology 20, 979-989. (ucsf.edu)
Frontiers in cell and developmental biology. (lu.se)

Today, it is generally thought that the combination of determinants deposited by the mother during oogenesis and the inductive signals between different cells trigger the specification of different cell lineages during development of the embryo [ 7 , 8 ]. (biomedcentral.com)

Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)

Transplantation experiments have revealed that most cells which can perform the hallmark feature of SSCs (that is, re-establishing full spermatogenesis in testes lacking germ cells) are found within the single uSPG population, but may also be present among paired and aligned progenitors ( Kubota and Brinster, 2018 ). (elifesciences.org)

Congenital hydronephrosis caused by ureteropelvic junction obstruction (UPJO) eventually leads to renal interstitial fibrosis and atrophy, after a series of pathophysiological problems. (bjbms.org)

However, FOXC2-producing uSPGs were also capable of self-renewal, forming cells which feature genetic markers associated with SSCs. (elifesciences.org)
Homeostatic epidermal stem cell self-renewal is driven by local differentiation. (ucsf.edu)

Cell-to-cell interactions set off a cascade of events that may result in T- or B-cell activation and, ultimately, host defense. (medscape.com)
In unicellular parasites, they perform a wide variety of cellular functions that require movement, including differentiation, host interactions, and cell invasion. (pberghei.eu)

T lymphocytes for adoptive cell therapy against hematological cancer. (upstate.edu)

The viral genome maintains itself as an episome in basal cells, where the viral genes are poorly expressed. (ghise-ioan.ro)

In a whole-genome sequencing in 17 Esophageal Squamous Cell Carcinoma cases and whole-exome sequencing in 71 cases, Song (2014), reported ASH1L alterations. (cancerindex.org)
risk of esophageal squamous cell carcinoma. (who.int)
PMID:18786442 mutations and the risk of esophageal squamous cell carcinoma. (who.int)

In a number of animal species, MZT roughly coincides with the mid-blastula transition (MBT) [ 20 ] when cells become motile and divide asynchronously. (biomedcentral.com)
Multiciliated cells (MCC) contain hundreds of motile cilia used to propel fluid over their surface. (elifesciences.org)
Each MCC contains hundreds of motile cilia, microtubule-based organelles that generate the motive force to move fluid over the surface of the cell. (elifesciences.org)

We carried out transfection experiments using three pancreatic cancer cell lines (MiaPaCa-2, BxPC-3, and SW1990) and one pancreatic duct epithelial cell line (HPDE6c7). (nagoya-u.ac.jp)

When a single uSPG divides, it can sometimes produce paired daughter cells that remain connected after mitosis. (elifesciences.org)
C ) Expansion of both the undifferentiated (A spermatogonia) and differentiated (A1 spermatogonia) spermatogonial populations occurs by mitosis of these cell types, regulated in part by FSH. (jci.org)

Microtrauma of the suprabasal epidermal cells enables the virus to infect the cell within the low risk hpv cause cancer layer. (ghise-ioan.ro)
A maximum projection of GCaMP6s Ca 2+ -sensor signal from a 30-min recording of the epidermal basal stem cell layer in a live mouse. (silverchair.com)

HIF-1α could bind to the promoter region of proliferating cell nuclear antigen ( PCNA ) and PROM1 (CD133) to mediate their transcription and expression. (bjbms.org)

Recently, the first in vitro norovirus cell culture model was reported for a virus that infects mice ( 18 , 19 ). (cdc.gov)

Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages. (biomedcentral.com)
Developmental Cell 47, 697-710.e3. (ucsf.edu)

Their multi‑functional cargo have been indicated to regulate a vast number of biological pathways in target cells. (spandidos-publications.com)

In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling , cellular differentiation , and cell death , as well as maintaining control of the cell cycle and cell growth . (wikipedia.org)
1 , 2 , 3 In each menstrual cycle, the dominant follicle that ovulates its egg originates from a primordial follicle that was recruited to initiate growth almost 1 year earlier (Fig. 2). (glowm.com)
Babatz, F., Naffin, E., and Klämbt, C. The Drosophila Blood-Brain Barrier Adapts to Cell Growth by Unfolding of Pre-existing Septate Junctions. (ucsf.edu)
Although studies have identified unique transcription factors in the selection of normal pancreatic lineages, the cells of origin and molecular mechanisms arbitrating PDAC growth are poorly defined. (amegroups.org)
Our results demonstrate that the highly differentiated 3-D cell culture model can support the natural growth of human noroviruses, whereas previous attempts that used differentiated monolayer cultures failed. (cdc.gov)

The General Pathology course provides the students with the fundamentals of modern cellular and molecular pathology. (uninsubria.eu)
The myosin superfamily is comprised of molecular motors present during early eukaryotic cell evolution. (pberghei.eu)
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. (cancerindex.org)
Cellular and Molecular Life Sciences. (lu.se)

Defects in the biogenesis of the acrosome often lead to the impaired development of sperm cells and consequently, to the inability to fertilize the oocyte. (nusl.cz)
Cook and Hurley preview two related studies examining the role of ATG9A in autophagosome biogenesis in mammalian cells. (silverchair.com)

Furthermore, human cDNA of NDRG1 from normal placenta was cloned into a eukaryotic expression vector and transfected into the three cancer cell lines. (scirp.org)
N. van Belzen, W. N. Dinjens, B. H. Eussen and F. T. Bosman, "Expression of Differentiation-Related Genes in Colorectal Cancer: Possible Implications for Prognosis," Histology and Histopathology, Vol. 13, No. 4, 1998, pp. 1233-1242. (scirp.org)
The team started by screening the expression profile of individual cells in a population of mouse uSPGs containing both SSCs and progenitors. (elifesciences.org)
More specifically, the lineage-tracing experiments showed that FOXC2-producing uSPGs could produce paired uSPGs that would then either divide to form two single uSPGs (including some that retained Foxc2 expression), or form chains of aligned uSPGs containing at most one FOXC2-producing cell ( Figure 1A ). (elifesciences.org)
This study aimed to determine the expression of renal stem cell marker CD133 in children of different ages and the regulatory effect of stem cell microenvironment. (bjbms.org)

Other cellular components of the innate immune system include mononuclear phagocytes, dendritic cells, and NK cells. (medscape.com)
Dendritic cells (DCs) are essential for the development of asthma via presenting allergens, causing Th2 skewing and eosinophil inflammation. (nagoya-u.ac.jp)
in migrating macrophages and dendritic cells, suggesting a novel, cell type-specific function for this complex. (silverchair.com)

Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy . (wikipedia.org)
Microvesicles have a diameter ranging from 100 nm to 1 µm and are released by cell membrane budding. (spandidos-publications.com)
2016). In a subsequent study, we found that AMP-17 can impair cell wall integrity, destroy cell membrane structure, and increase cell membrane permeability in C. albicans (Ma et al. (researchsquare.com)
show that human atlastin-3 is a robust membrane fusion catalyst that maintains ER network structure in cells. (silverchair.com)

To identify major effectors, we used CRISPR-Cas9 to introduce H3.3K27M and G34R mutations into previously H3.3-wildtype brain cells, while in parallel reverting the mutations in glioma cells back to wildtype. (nature.com)

There are three main subtypes of NSCLC which are adenocarcinoma (~40% of cases), squamous cell carcinoma (~25-30% of cases), and large-cell carcinoma (~10-15% of cases). (hindawi.com)
Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch squamous cell carcinoma in a high-risk region in Iran. (who.int)

J. Cell Biol. (wikipedia.org)

New evidence in mice suggests that cells expressing the transcription factor FOXC2 may form a reservoir of quiescent stem cells that contributes to sperm formation. (elifesciences.org)
This involves spermatogonial stem cells (SSCs) dividing to form undifferentiated spermatogonia (uSPGs), which then progress through the meiotic and haploid phases of spermatogenesis to form mature sperm ( de Rooij, 1998 ). (elifesciences.org)
Renal repair after injury depends on renal stem cells. (bjbms.org)
Renal stem cells from children of different ages were identified and screened out by flow cytometry in the study. (bjbms.org)
The content of CD133 + renal stem cells was the highest in the neonatal group and it decreased with the increase of age. (bjbms.org)
We expect our results to provide a research basis for the treatment and clinical application of renal stem cells. (bjbms.org)
Positive CD133 (CD133 + ) renal cells disappear as kidney matures, and the stem cells selectively develop into the urinary pole of the glomerulus. (bjbms.org)

[20] This finding has led to general acceptance of the endosymbiotic hypothesis - that free-living prokaryotic ancestors of modern mitochondria permanently fused with eukaryotic cells in the distant past, evolving such that modern animals, plants, fungi, and other eukaryotes are able to respire to generate cellular energy . (wikipedia.org)

A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain. (ucsf.edu)

1989. Cellular alterations and enhanced induction of cleft palate after coadministration of retinoic acid and TCDD. (cdc.gov)

Neuroendocrine mechanisms, particularly those related to 5-HT, are associated with the differentiation and activation of osteoblasts and osteoclasts. (bvsalud.org)

Mechanistically dissect key RNA metabolism changes causing neural cell dysfunction: Our priorities are to understand the cause and consequence of dysregulated splicing events, and to identify intrinsic master regulators driving transcriptome-wide signatures of neurological disease. (ed.ac.uk)

transplanted a population of uSPGs enriched in these cells into the testes of mice treated with busulfan, a toxic compound that kills endogenous germ cells. (elifesciences.org)

High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle. (asspub.ro)

2016). AA also takes part in the regeneration of α-tocopherol (vitamin E) in photosynthetic membranes and participates in chloroplast metabolism as a cofactor for violaxanthin de-epoxidase, an enzyme involved in xanthophyll cycle-mediated photoprotection (Smirnoff and Wheeler, 2000). (deepdyve.com)

The acrosome is a crucial organelle for sperm cells. (nusl.cz)

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Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes80

Disciplines and Occupations1

Information Science3

Tight junctions1

Proliferation15

Apoptosis5

Adherens2

Regulation2

Homeostasis5

Regulates3

Pathway6

Extracellular4

Proteins6

Progenitor cells5

Induce1

Epithelium8

Tissue10

Protein11

Tumor8

Processes6

Epithelial cells7

Tissues3

Receptors3

Mechanism4

Gene5

Vivo1

Biology2

Signals1

Small intestinal1

20181

Atrophy1

Self-renewal2

Interactions2

Adoptive1

Basal cells1

Esophageal Squamous Cell Carc3

Motile3

Pancreatic cancer1

Mitosis2

Epidermal2

Mediate1

Vitro1

Developmental2

Regulate1

Growth5

Molecular4

Biogenesis2

Expression5

Dendritic cells3

Membrane4

Mutations1

Squamous2

Biol1

Stem cells7

Eukaryotic cells1

Drosophila1

Alterations1

Osteoclasts1

Regulators1

Germ cells1

Dysregulation1

Regeneration1

Sperm1