Cellular catenins. Medical search. Frequent questions

Finally, we corroborated that CTNNB1 (or Axin1) ectopic expression or activation of Wnt/β-catenin pathway abrogated the effects of SNHG8 downregulation on the cellular process of ovarian carcinoma cells. (iospress.com)
To summarize, SNHG8 acted as an oncogene in ovarian carcinoma via targeting Wnt/β-catenin pathway, providing a new insight into understanding ovarian carcinoma at the molecular level. (iospress.com)
The Wnt/β-catenin pathway plays a critical role in embryonic development, maintenance of multipotent progenitor cell populations and proliferation of many tissue types [1] , [2] . (plos.org)
β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. (wikipedia.org)
Notably, the C-terminal segment of β-catenin can mimic the effects of the entire Wnt pathway if artificially fused to the DNA binding domain of LEF1 transcription factor. (wikipedia.org)
Mechanosensation of tissue stiffness activates the Rho/ROCK pathway to increase actomyosin-mediated cellular tension to re-establish force equilibrium. (ucsf.edu)
To analyze whether and how the quantitative ratio between receptor and rafts affects LRP6 phosphorylation and WNT/β-catenin pathway activation, we present a computational modeling study, that for the first time employs realistic raft numbers in a compartment-based pathway model. (frontiersin.org)
Several studies suggested an involvement of lipid rafts in the WNT /β-catenin pathway. (frontiersin.org)
Here, we apply computational modeling to analyze whether and how the quantitative ratio between receptor and rafts affects LRP6 phosphorylation and WNT/β-catenin pathway activation. (frontiersin.org)
Professor Scholpp said 'The exciting results of this multidisciplinary, multiscale project provides a step change in understanding how the Wnt signalling pathway operates at the molecular and cellular level in a living vertebrate animal. (news-medical.net)
The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)
The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
This article presents the roles of the Wnt/β-catenin pathway in cancer and current therapeutic strategies involving this pathway. (chemdiv.com)
Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)
MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. (cancerindex.org)
Based on the findings, the inhibition of miR-543 was found to play a tumor suppressive role in PA through the down-regulation of Wnt/β-catenin pathway by negatively regulating Smad7. (cancerindex.org)
Beta-catenin is a central component of the Wnt signaling pathway that controls cell proliferation and differentiation. (eurekalert.org)
Activation of the Wnt pathway stabilizes beta-catenin, allowing it to move into the cell nucleus and control the expression of many different genes. (eurekalert.org)
Surprisingly, this decrease did not involve an established pathway of beta-catenin destruction. (eurekalert.org)
The team found that CD9 and CD82 boosted the release of exosomes containing beta-catenin, thereby reducing cellular levels of the protein and inhibiting the Wnt pathway. (eurekalert.org)
β-catenin protein is an integral part of the canonical Wnt signaling pathway. (tocris.com)
Mutations in β-catenin, axin and APC have been discovered in numerous cancers, and other members of the canonical pathway may also contribute to misregulation of Wnt signaling. (tocris.com)
The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. (tocris.com)
Weng X, Lin P, Liu F, et al: Achyranthes bidentata polysaccharides activate the Wnt/β-catenin signaling pathway to promote chondrocyte proliferation. (spandidos-publications.com)
One pathway widely recognized for its influence over these processes in both normal development and pathophysiology is the Wnt/β-catenin signaling pathway ( 1 ). (rupress.org)
In human breast epithelial cells Wnt-5a activates the canonical b-catenin pathway as well as the non-canonical Ca2+/calmodulin and planar cell polarity (PCP) pathways. (lu.se)
The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN. (bvsalud.org)

β-catenin, a key element of mechanotranscription pathways, was stabilized by ROCK activation leading to nuclear accumulation, transcriptional activation, and consequent hyperproliferation and skin thickening. (ucsf.edu)
A team of international researchers, including experts from the University of Exeter's Living Systems Institute, has identified how signalling pathways of Wnt proteins - which orchestrate and control many cell developmental processes - operate on both molecular and cellular levels. (news-medical.net)
Primary cilia are sensory organelles that coordinate multiple cellular signaling pathways, including Hedgehog (HH), Wingless/Int (WNT) and Transforming Growth Factor-β (TGF-β) signaling. (springer.com)
Prostate cancer-secreted CCN3 uses the GSK3β and β-catenin pathways to enhance osteogenic factor levels in osteoblasts. (nih.gov)
The present study evaluated cell viability, expression levels of collagen II (Col II) and matrix metalloproteinase‑13 (MMP‑13), and activity of the Wnt/β‑catenin and NF‑κB signaling pathways in treated SW1353 cells. (spandidos-publications.com)
The present results suggested that IL‑1β could decrease Col II expression and increase MMP‑13 expression at both the mRNA and protein levels, and also activate the Wnt/β‑catenin and NF‑κB signaling pathways in SW1353 cells. (spandidos-publications.com)
The Abu-Remaileh Lab is interested in identifying novel pathways that enable cellular and organismal adaptation to metabolic stress and changes in environmental conditions. (stanford.edu)
Several critical signaling pathways control cellular proliferation, migration, and polarization. (rupress.org)
Since the L-ornithine produced by arginase will further metabolize to polyamines, which is involved in the multiple fundamental cellular functions, arginase has been revealed to impact an array of pivotal downstream metabolic pathways [ 6 ]. (hindawi.com)

Canonical Wnt/β-catenin signaling is initiated by binding of Wnt ligands to Frizzled (Fzd)-LRP5/6 receptor complexes, leading to inactivation of the destruction complex and stabilization of β-catenin. (plos.org)
Because of the conditioning step, this agonist-dependent step results in a stabilization of β-catenin and activation of transcription. (arizona.edu)
Axin1 and GSK3β are recruited to the receptor complex upon Wnt stimulation and this leads to a breakdown of the destruction complex and β-catenin stabilization. (nature.com)
β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)
Axin recruitment to the PM represents a key step in β-catenin stabilization, which ultimately leads to β-catenin nuclear translocation to act as a coactivator of transcription with T cell factor/lymphoid enhancer-binding factor (TCF/LEF) at Wnt target genes. (rupress.org)
Sirtuin 7 Promotes Mesenchymal to Epithelial Transition by ß-Catenin Redistribution and Stabilization. (bvsalud.org)
This transition was accompanied by typical N- to E- cadherin transition, stabilization of ß- catenin , and the downregulation of transcription factors responsible for maintenance of mesenchymal phenotype ( Snail , Slug , and Zeb1). (bvsalud.org)

The first is a conditioning step that involves an agonist-independent association of the FP B receptor with phosphatidylinositol 3-kinase followed by constitutive internalization of a receptor complex containing E-cadherin and β-catenin. (arizona.edu)
The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and δ-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-mediated interaction, but have incompletely characterized neuronal functions. (jneurosci.org)
Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
β-catenin also plays an essential role in cell-cell adhesion, and is thought to maintain the attachment of stem cells to their niche by interacting with membrane-bound cadherin and α-catenin. (tocris.com)
Additionally, overexpression of ARG1 led to a significant increase in the expression of Vimentin, N-cadherin, and β -catenin both at protein and mRNA levels, which promotes the EMT process. (hindawi.com)
E-cadherin is a calcium dependent adhesion molecule with important roles in epithelial intercellular adhesion and cellular structure. (cdc.gov)
E-cadherin immunofluorescent double labeling can also be used with activated caspase 3 or â-catenin immunofluorescence to localize the expression of these proteins in damaged airways. (cdc.gov)

Once stabilized, β-catenin accumulates and translocates to the nucleus, where it complexes with TCF/LEF to activate transcription of target genes, such as MYC and CCND1 . (plos.org)
β-catenin then translocates to the nucleus where it forms a complex with TCF/LEF transcription factors and activates Wnt target gene expression 28 , 29 . (nature.com)

In the absence of Wnt ligands, a complex containing APC, AXIN and GSK3 phosphorylates β-catenin, marking it as a substrate for ubiquitination by β-TrCP and subsequent proteasomal degradation. (plos.org)
In addition to ligand-regulated degradation of β-catenin, Wnt signaling is antagonized by extracellular factors that inhibit the ability of Wnt ligands to bind to Fzd and initiate signaling, such as the secreted frizzled-related proteins (SFRP1, WNT inhibitory factor (WIF) and dickkopf (DKK) [3] . (plos.org)
Degradation of β-catenin is thus mediated by this N-terminal segment. (wikipedia.org)
These kinases phosphorylate β-catenin, leading to its ubiquitylation and proteasomal degradation. (nature.com)
TMEM9-v-ATPase hyperactivates Wnt/β-catenin signalling via lysosomal degradation of adenomatous polyposis coli (APC). (nature.com)
Our results reveal the unexpected roles of TMEM9-controlled vesicular acidification in hyperactivating Wnt/β-catenin signalling through APC degradation, and propose the blockade of TMEM9-v-ATPase as a viable option for colorectal cancer treatment. (nature.com)
The kinases phosphorylate β-catenin, leading to its ubiquitin-mediated proteasomal degradation. (rupress.org)

β-Catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. (wikipedia.org)

While canonical, β-catenin-dependent Wnt signaling is well studied and has been linked to many forms of cancer, much less is known about the role of non-canonical, β-catenin-independent Wnt signaling. (nature.com)
Here, we aimed at identifying a β-catenin-independent Wnt target gene signature in order to understand the functional significance of non-canonical signaling in colon cancer cells. (nature.com)
Furthermore, we show that the ligands Wnt5a/b are upstream regulators of the non-canonical signature and moreover regulate proliferation of cancer cells in a β-catenin-independent manner. (nature.com)
Non-canonical, β-catenin-independent Wnt signaling is proposed to have a multifunctional role in tumorigenesis, being either tumor supportive or suppressive depending on tumorstage and tumortype 9 . (nature.com)
We have used conditional gene deletion of mouse β-catenin in Sox17-positive embryonic and extra-embryonic endoderm as well as vascular endothelial progenitors to address the function of canonical Wnt signalling in cell lineage formation and patterning. (biologists.com)

An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
Exosomal release of beta-catenin and inhibition of Wnt signaling may explain why CD82 and CD9 suppress tumor metastasis. (eurekalert.org)
Researchers reveal a new way in which cells restrain beta-catenin and potentially suppress tumor metastasis: the protein can be ejected from cells in small vesicles called exosomes. (eurekalert.org)
CD82 may act as a metastasis suppressor by targeting beta-catenin for exosomal release and thereby reducing its availability as a Wnt signaling mediator," Caplan proposes. (eurekalert.org)

Here we identify CSNK1E , the gene encoding casein kinase 1 epsilon (CK1ε) as required specifically for the proliferation of breast cancer cells with activated β-catenin and confirm its role as a positive regulator of β-catenin-driven transcription. (plos.org)
FP prostanoid receptors have been identified as two isoforms named FP A and FP B . We have shown that the FP B isoform, but not the FP A , activates β-catenin-mediated transcription. (arizona.edu)
We have shown that the FPB isoform, but not the FPA, activates β-catenin-mediated transcription. (arizona.edu)
β-Catenin is a dual function protein, involved in regulation and coordination of cell-cell adhesion and gene transcription. (wikipedia.org)
In some cases, Sox17 and β-catenin synergistically activate transcription apparently independent of Tcfs, whereas on other enhancers, Sox17 represses β-catenin/Tcf-mediated transcription to spatially restrict gene expression domains. (xenbase.org)
Our findings establish Sox17 as a tissue -specific modifier of Wnt responses and point to a novel paradigm where genomic specificity of Wnt/β-catenin transcription is determined through functional interactions between lineage-specific Sox TFs and β-catenin/Tcf transcriptional complexes. (xenbase.org)
We further wanted to ascertain whether this protein interaction was direct using recombinant versions of purified b-catenin and WT1 protein but failed to detect any association ( Online Supplementary Figure S1B, C ). This suggested that perhaps the interaction is mediated through a post-translational modification, common partners such as WTX, 8 or cellular structures like DNA, given their well-documented roles in transcription. (haematologica.org)
Accumulation of β-catenin in the cell cytoplasm prompts its translocation to the nucleus, where it interacts with members of the TCF/LEF family of transcription factors and induces the transcription of Wnt target genes. (tocris.com)

Aberrant TCF-β-catenin signaling is also evident in many cancers, and results in altered expression of genes controlling cell proliferation, differentiation, migration and apoptosis. (tocris.com)
Our study demonstrates that ERMS cells are vulnerable to EHMT2 inhibitors and suggest that targeting the EHMT2-DKK1-β-catenin node holds promise for differentiation therapy. (elifesciences.org)
In summary, we deciphered the cellular heterogeneity and the molecular dynamics during fibrocartilage differentiation. (elifesciences.org)
Beta-catenin helps control the activity (expression) of particular genes and promotes the growth and division (proliferation) of cells and the process by which cells mature to carry out specific functions (differentiation). (medlineplus.gov)

The cellular conditioning described here for the FP B illustrates the potential of the receptor to alter the signaling environment of a cell even in the absence of agonist and has general significance for understanding G-protein-coupled receptor signaling. (arizona.edu)
Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. (wikipedia.org)
It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. (wikipedia.org)
β-Catenin was initially discovered in the early 1990s as a component of a mammalian cell adhesion complex: a protein responsible for cytoplasmatic anchoring of cadherins. (wikipedia.org)
But very soon, it was realized that the Drosophila protein armadillo - implicated in mediating the morphogenic effects of Wingless/Wnt - is homologous to the mammalian β-catenin, not just in structure but also in function. (wikipedia.org)
Thus, β-catenin became one of the first examples of moonlighting: a protein performing more than one radically different cellular function. (wikipedia.org)
2 Protein interactions are critical to the stability, localization and activity of b-catenin, and we recently performed the first proteomic analyses of the b-catenin interactome in myeloid cells. (haematologica.org)
In order to idenitfy appropriate cell lines in which to study b-catenin:WT1 interplay we first performed a screen of myeloid cell lines to examine b-catenin and WT1 protein expression. (haematologica.org)
WT1 is an RNA-binding protein, 6 and β-catenin has also been shown to bind RNA, 7 so to confirm this interaction was not indirect via RNA binding we repeated WT1 Co-IP (with or without CHIR99021) after first confirming complete digestion of RNA through RNase A pre-treatment of cell lysates ( Figure 1E ). (haematologica.org)
A) Immunoblot of myeloid leukemia cell lines showing the relative level of b-catenin (~92 kDa) and WT1 (~50 kDa) protein, with b-actin (42 kDa) used to assess protein loading. (haematologica.org)
β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)
Overexpressing CD82 or CD9, members of the tetraspanin family of transmembrane proteins, suppressed Wnt signaling and reduced beta-catenin protein levels. (eurekalert.org)
The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes. (medlineplus.gov)
One protein with which APC associates is beta-catenin. (medlineplus.gov)
The shortened protein is unable to interact with the beta-catenin protein, which prevents the breakdown of beta-catenin when it is no longer needed. (medlineplus.gov)
This short protein cannot suppress the cellular overgrowth that leads to the formation of abnormal growths (polyps) in the colon, which can become cancerous. (medlineplus.gov)
TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)

Alterations in the localization and expression levels of β-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. (wikipedia.org)
Knockdown of erbin results in alterations in localization of δ-catenin. (jneurosci.org)
These results suggest a critical role for erbin in regulating dendritic morphogenesis by maintaining appropriate localization of δ-catenin. (jneurosci.org)
A prominent example for the decisive impact of lipid rafts on signaling is LRP6, whose localization to the same lipid rafts domain as the kinase CK1γ is crucial for its successful phosphorylation and the subsequent activation of the signalosome, hence WNT/β-catenin signaling. (frontiersin.org)
Even though LRP6 is homogenously distributed in the membrane and only a minor fraction is raft-associated, its localization to lipid rafts is vital for the activation of the LRP6 signalosome, hence wnt/β-catenin signaling. (frontiersin.org)

Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. (wikipedia.org)
The dendritic phenotype observed after erbin depletion is rescued by overexpression of δ-catenin and requires a domain in δ-catenin that has been shown to regulate dendritic branching. (jneurosci.org)
Knockdown of δ-catenin cannot be rescued by overexpression of erbin, indicating that erbin is upstream of δ-catenin. (jneurosci.org)
In the current study, evaluation of the expression of ARG1 and clinicopathological significance of ARG1 was carried out in the human HCC tissues microarray, and the ARG1 overexpression vector and shRNA-ARG1 plasmids were constructed for the assessment of the concrete effect of ARG1 on cellular behaviors of Huh7 cells. (hindawi.com)
Besides, in vitro study revealed that overexpression of ARG1 could enhance arginase activity, cell viability, migration, and invasion of Huh7 cells, and loss-of-function of ARG1 by shRNA interference could inhibit these cellular behaviors. (hindawi.com)

Our experiments indicate that colon cancer cells are dependent on both β-catenin-dependent and -independent Wnt signaling routes for growth and proliferation. (nature.com)

2021) Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling. (news-medical.net)
Yet, how Dvl disrupts the β-catenin DC and promotes assembly of the signalosome remained unclear. (rupress.org)
Excess beta-catenin promotes uncontrolled growth and division of cells, allowing the formation of desmoid tumors. (medlineplus.gov)

these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3 . (tocris.com)
In the absence of Wnt ligands, β-catenin is degraded via a destruction complex (DC) consisting of two core tumor suppressors that serve as scaffold proteins (APC and Axin) and two kinases (glycogen synthase kinase-3 β [GSK3β] and casein kinase 1 [CK1]) ( 4 ). (rupress.org)

Loss-of-function mutations in APC or AXIN or activating mutations in the gene encoding β-catenin, CTNNB1 , lead to aberrant activation of Wnt/β-catenin signaling and have been causally linked to tumorigenesis of the colon, liver and skin [1] , [4] . (plos.org)
https://doi.org/10.1083/jcb.202205069 ) show Dvl2 undergoes liquid-liquid phase separation to stabilize β-catenin by pulling Axin into its biomolecular condensate at the plasma membrane. (rupress.org)
La vía de señalización se inicia con la unión de las PROTEÍNAS WNT a la superficie de las células de los RECEPTORES WNT que interactúan con el COMPLEJO DE SEÑALIZACIÓN AXIN y una serie de segundos mensajeros que influyen en las acciones de la BETA-CATENINA. (bvsalud.org)

Moreover, TMEM9 transactivated by β-catenin functions as a positive feedback regulator of Wnt signalling in colorectal cancer. (nature.com)

Cellular Physiology and Biochemistry (2019) 51 (6): 2547-2563. (karger.com)

This constitutive internalization conditions the cell for subsequent β-catenin signaling by increasing the cellular content of cytosolic β-catenin. (arizona.edu)

ChemDiv proposes the new library of beta-catenin inhibitors/modulators. (chemdiv.com)

Although mutations in these same genes have not been observed as recurrent genetic events in breast tumors, there is strong evidence implicating Wnt/β-catenin activity in breast tumorigenesis. (plos.org)

Although stimulation of the FP A isoform activates Rho and induces cellular shape change, it does not activate β-catenin signaling, because the FP A does not undergo constitutive internalization and does not condition the cell for β-catenin signaling. (arizona.edu)

2020), Sox17 and β-catenin co-occupy Wnt-responsive en. (xenbase.org)
Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network. (xenbase.org)
Sox17 and β-catenin co-occupy hundreds of key enhancers. (xenbase.org)
Sox17 lineage tracing in the definitive endoderm (DE) shows a cell-autonomous requirement for β-catenin in midgut and hindgut formation. (biologists.com)

Plakoglobin (also called γ-catenin) has a strikingly similar architecture to that of β-catenin. (wikipedia.org)
Not only their ARM domains resemble each other in both architecture and ligand binding capacity, but the N-terminal β-TrCP-binding motif is also conserved in plakoglobin, implying common ancestry and shared regulation with β-catenin. (wikipedia.org)
δ-Catenin belongs to the p120 catenin (p120ctn) family of catenins and binds to the cytoplasmic domains of type 1 and 2 cadherins at a membrane proximal region that is not involved in binding of either β-catenin or plakoglobin. (jneurosci.org)

β-catenin is a multipurpose and evolutionarily conserved molecule that plays a critical role by metazoans in a variety of processes in development and homeostasis. (chemdiv.com)

In cardiac muscle, β-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocytes. (wikipedia.org)

However approaches to modulate β-catenin activity for therapeutic purposes have proven elusive to date. (plos.org)
PWD/Ph-encoded genetic variants modulate the cellular Wnt/β-Catenin response to suppress ApcMin-triggered intestinal tumor formation. (mpg.de)

These studies identify CK1ε as a critical contributor to activated β-catenin signaling in cancer and suggest it may provide a potential therapeutic target for cancers that harbor active β-catenin. (plos.org)
Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)
The exosomal release of beta-catenin may be compromised in certain cancers, where Wnt signaling is often hyperactive. (eurekalert.org)

Consistent with the different origins of dorsal and ventral dermal cells, our results demonstrate both conserved and divergent roles ofβ-catenin/Wnt signaling in dermal development. (biologists.com)

In this issue, we generally review the mechanisms of cellular senescence in diabetic nephropathy, which involve telomere attrition, DNA damage, epigenetic alterations, mitochondrial dysfunction, loss of Klotho, Wnt/ β -catenin signaling activation, persistent inflammation, and accumulation of uremic toxins. (hindawi.com)

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. (ucsf.edu)
Tumor number, growth, and progression were increased by ROCK activation, while ROCK blockade was inhibitory, implicating actomyosin-mediated cellular tension and consequent collagen deposition as significant tumor promoters. (ucsf.edu)

In summary, our results support distinct functions of Tsc1 and Tsc2 in cellular signaling as the two genes affect ciliary length control and HH signaling via different mechanisms. (springer.com)

Vertebrate catenins contain a large number of Arm-domains including 3 subfamilies: β-tencains, p120 and plakophilins 1 and 3. (chemdiv.com)

b-Catenin is the central mediator of Wnt signaling and is frequently overexpressed in AML in which it is associated with poor prognosis. (haematologica.org)

HelixC is not necessary for β-catenin to function in cell-cell adhesion. (wikipedia.org)

We show that short hairpin RNA-mediated knockdown of erbin and knockdown or genetic ablation of δ-catenin severely impaired dendritic morphogenesis in hippocampal neurons. (jneurosci.org)

ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)

The core of β-catenin consists of several very characteristic repeats, each approximately 40 amino acids long. (wikipedia.org)
The primary structure of beta-catenin consists of an NH2-terminal domain (NDT), a central region represented by 12 Arm-repeats (R1-12), and a COOH-terminal end (CTD). (chemdiv.com)

Furthermore, we demonstrate that breast cancer cells that harbor activated β-catenin activity exhibit enhanced sensitivity to pharmacological blockade of Wnt/β-catenin signaling. (plos.org)

β-catenin belongs to the catenin molecule family. (chemdiv.com)

δ-Catenin-null neurons have no alterations in global levels of active Rac1/RhoA. (jneurosci.org)

However, our knowledge of the cellular and molecular mechanisms that promote the formation and maintenance of dendritic arbors remains incomplete. (jneurosci.org)
In the present review, we will focus on the role of cellular senescence and its related mechanisms in DN. (hindawi.com)
Zebrafish Fin: Complex Molecular Interactions and Cellular Mechanisms Guiding Regeneration. (uni-ulm.de)

All the diversity of catenins forms a complex functional network. (chemdiv.com)
Antagonist of the Tcf/β-catenin complex. (tocris.com)

Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)

Simultaneous loss of erbin and δ-catenin does not enhance severity of this phenotype. (jneurosci.org)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)

In this review, we discuss current understanding of the role and mechanism of cellular senescence in kidney fibrosis. (frontiersin.org)
In this review, we summarize the evidence linking cellular senescence to the pathogenesis of CKD and discuss current understanding of the mechanism and regulators controlling senescence. (frontiersin.org)
We now report that the mechanism of this FP B -specific activation of β-catenin signaling occurs in two steps. (arizona.edu)
We now report that the mechanism of this FPB-specific activation of β-catenin signaling occurs in two steps. (arizona.edu)
Irisin has been reported to regulate bone metabolism via the cellular autocrine mechanism and play a protective role in rat OA. (spandidos-publications.com)

This applies a tensile signal to the actin-binding domain (ABD) of α-catenin, which provides a clutch to promote lateral adhesion growth and inhibit the lamellipodial activity necessary for migration. (ibecbarcelona.eu)

In this study, we demonstrate that Wnt/β-catenin signaling is necessary for the survival of early ventral dermal progenitors. (biologists.com)
In addition, we show that, at later stages,Wnt/β-catenin signaling is sufficient for ventral dermal cell specification. (biologists.com)

β-Catenin is widely expressed in many tissues. (wikipedia.org)
It has been postulated that Wnt/β-catenin signalling forms concentration gradients across responsive tissues and act as morphogens. (exeter.ac.uk)

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