Cellular behavior in cells. Medical search. Frequent questions

We explored how basic properties of neural cells, nuclei polarization, phenotypic differentiation and distribution/migration, were affected by the culture at poly-L-lactic acid (PLLA) fibrous scaffolds, using a multipotent mitogen-expanded human neural progenitor cell (HNPC) line. (diva-portal.org)
We demonstrated that the topography of in vivo-resembling PLLA scaffolds significantly influences HNPC behavior, proven by different migration behavior, phenotypic differentiation potential and nuclei polarization. (diva-portal.org)
Huang and Chang then looked at the proteins GATA1 and PU.1, transcription factors that normally favor differentiation into red and white blood cells, respectively. (sciencedaily.com)
Users of the Molecular Foundry created a mimic of proteoglycans - surface-bound sugars - that are critical in the differentiation of embryonic stem cells into neural cells. (lbl.gov)
Stem cell differentiation is determined by growth factor signaling, which is mediated by proteoglycans, long chains of sugars that are bound to protein surfaces. (lbl.gov)
N-myc downstream regulated gene 1 (NDRG1), also known as differentiation related gene 1, was previously identified as an up - regulated gene upon cellular differentiation. (scirp.org)
Even though its sequence along with its expressional pattern in cancer cell lines are evident, the functional aspects concerning cell proliferation, viability, differentiation and cell cycle regulation of NDRG1 remains vague. (scirp.org)
These results revealed that NDRG1 is functional in prostate cancer cells and able to induce expression of differentiation factors through p53 independent pathway. (scirp.org)
T. Napso, N. Azzam, A. Lerner and F. Fares, " N-myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 568-574. (scirp.org)
A Novel Gene Which Is Up-Regulated during Colon Epithelial Cell Differentiation and Down-Regulated in Colorectal Neoplasms," Laboratory Investigation: A Journal of Technical Methods and Pathology, Vol. 77, No. 1, 1997, pp. 85-92. (scirp.org)
In summary, we deciphered the cellular heterogeneity and the molecular dynamics during fibrocartilage differentiation. (elifesciences.org)
Xavier Darzacq studies transcription regulation during cellular differentiation. (berkeley.edu)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
Neuroblastoma tumor initiating cells are immature with a neural crest-like phenotype and downregulation of HIF-2alpha in these cells results in neuronal sympathetic differentiation and the cells become phenotypically similar to the bulk of neuroblastoma cells found in clinical specimens. (lu.se)
2 (2007) observed that cell adhesion and proliferation, as well as the osteogenic differentiation of mouse mesenchymal stem cells (MSCs) to Ti discs were significantly similar to those on the plastic surface of the culture, indicating Ti as an excellent material for repairing hard tissue in the field of bone tissue engineering. (bvsalud.org)
The term "adhesion" to the biomaterial refers to the most important phase, since the quality of it will influence morphology and the capacity of cell proliferation and differentiation 3 . (bvsalud.org)

Through these so-called epigenetic mechanisms, a cell's behavior and identity, and thus its likelihood of becoming diseased, can be changed. (mskcc.org)
The cell's behavior and identity is determined by the collective sum of the genes it uses. (helix.com)

J Cell Sci (2018) 131 (22): jcs221747. (biologists.com)
Cellular Physiology and Biochemistry (2018) 47 (1): 11-25. (karger.com)

Hinck's lab has identified a family of cellular proteins that help regulate cell proliferation and migration and act as breast tumor suppressors. (ucsc.edu)
Unpredictably, cell cycle progression, cell proliferation and DNA synthesis were unaffected fol lowing NDRG1 expression. (scirp.org)
We report an unusual case of Langerhans cell granulomatosis (LCG) manifested as a villous synovial proliferation in a 38-year-old female jogger. (medscape.com)
It emphasizes the importance of immunocytochemistry to separate this histiocyte-like cell proliferation from true histiocytic and other dendritic cell types. (medscape.com)
Functional studies suggest that TAGLN2 promotes ESCC progression, while CRNN inhibits it by regulating cell proliferation. (bvsalud.org)

MCP scientists tackle open problems in cell and tissue biology, immunology, and neuroscience. (stanford.edu)
Due to its relatively independent function accompanying its different cellular localization, a deeper understanding of HMGB1 biology in the cochlea is indispensable for guiding future precise therapeutic interventions. (frontiersin.org)
Cancer research at UC Santa Cruz includes faculty in a wide range of departments, including Applied Math and Statistics, Biomolecular Engineering, Chemistry and Biochemistry, Electrical Engineering, Microbiology and Environmental Toxicology, and Molecular, Cell, and Developmental Biology. (ucsc.edu)
The mechanisms by which cells control their growth and size are poorly understood and represent a fundamental unsolved problem in cell biology. (ucsc.edu)
Led by Sui Huang, MD, PhD, a Visiting Associate Professor in the Children's Hospital Boston Vascular Biology Program (now also on the faculty of the University of Calgary), and Hannah Chang, an MD/PhD student in Children's Vascular Biology Program, the researchers examined how blood stem cells "decide" to become white blood cell progenitors or red blood cell progenitors. (sciencedaily.com)
We need all these interdisciplinary approaches, which includes biology, engineering, and computational modeling, to ensure stem cells are stable, functional, and efficiently differentiate before using a hiPSCs source in a clinical setting," Smith said. (jhu.edu)
We are excited to announce Ellen Lumpkin will join the MCB faculty in the Division of Cell & Developmental Biology this July. (berkeley.edu)
Dr. Lumpkin is currently an Associate Professor of Somatosensory Biology (in Dermatology) and of Physiology and Cellular Biophysics at Columbia University. (berkeley.edu)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)

Chung TH, Wu SH, Yao M, Lu CW, Lin YS, Hung Y, Mou CY, Chen YC, Huang DM (2007) The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles 3T3-L1 cells and human mesenchymal stem cells. (springer.com)
Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
Such development pattern shares an overlapping biological behavior with the growth plate, which is a process of mesenchymal stem cells differentiating into chondrogenic cells and then sequentially into fibrocartilage cells ( Killian, 2022 ). (elifesciences.org)
The tumor has the following three components: epithelial cell, myoepithelial cell, and stromal/mesenchymal. (medscape.com)
Aim: To evaluate the adhesion of mouse bone marrow mesenchymal cells (MBMMC) on different titanium surfaces. (bvsalud.org)
mesenchymal stem cells, bone marrow, titanium. (bvsalud.org)

The discovery of neural circuits underlying social behavior is among the most fascinating goals in modern neuroscience: the specific brains areas and neuronal subsets in which social cues are detected and encoded by the brain in order to lead to distinct behavioral responses, and the mechanisms by which social responses are modulated by animal's physiological and reproductive status are still very poorly understood. (harvard.edu)
Parental behavior, a set of interactions aimed at the care and protection of the young, serves as a prime example of social behavior. (harvard.edu)
These findings represent the first genetic characterization of command-like neurons for parental responses in vertebrates and illustrate how the activation of a single cell population is able to switch on/off a social behavior. (harvard.edu)

These models are more predictive of clinical outcomes and are superior to cell lines for preclinical drug evaluation and therapeutic strategies. (biorxiv.org)
Patient-derived xenografts, or PDXs, have begun to supplant traditional cell lines due to their retention of clinical biomarkers and heterogeneity from the original tumour ( 10 ). (biorxiv.org)
The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)
Prognosis regarding the clinical behavior of the mucosal lesions has been extrapolated from knowledge of the cutaneous lesions. (medscape.com)
[ 8 ] This may well explain why phenotypically identical ependymomas from supratentorial, posterior fossa, and spinal locations may exhibit notably different clinical behaviors. (medscape.com)

Quantifying the mechanics and growth of cells and tissues in 3D using high resolution computational models. (crossref.org)
for example, they provide structural stability to cells and tissues, give motility to individual cells, carry messages within and between cells, and regulate gene expression and metabolism. (biologists.com)
This form of cellular research is essential to the study of regenerative medicine, which focuses on replacing or repairing damaged tissue, often through the use of stem cells, a special population of cells that can give rise to all tissues in the body. (jhu.edu)
Interestingly, the patterns' edges became densely packed with cells that organized and matured differently than the cells in the center, and expressed precursor markers that give rise to tissues such as the heart, muscle, and blood vessels. (jhu.edu)
As cells congregated and became more crowded at the edges of the shapes, they experienced more tension than the cells in the interior of the pattern, which seemed to trigger self-organization and the expression of those precursors that give rise to tissues. (jhu.edu)
The study advances one of the primary goals of regenerative medicine researchers to one day repair damaged tissues using a patient's own cells. (jhu.edu)
Put another way, controlling gene expression means AR can control the behavior of our cells, and that means these hormones can affect our physiology in numerous different tissues. (helix.com)
Exposure to radiation can wreak indiscriminate havoc on cells, tissues, and organs. (sciencedaily.com)
In vulnerable tissues, p53 levels go up and remain high, leading to cell death. (sciencedaily.com)
After radiation exposure, all four tissues expressed elevated p53 along with other markers of DNA and cellular damage as expected. (sciencedaily.com)
Embryonic stem cells are able to differentiate into a variety of different tissues. (lbl.gov)
Enthesis development has historically been studied with lineage tracing of individual genes selected a priori, which does not allow for the determination of single-cell landscapes yielding mature cell types and tissues. (elifesciences.org)
[ 1 ] Antigen-presenting cells or histiocyte-like cells containing Birbeck granules have been identified within inflamed synovial tissues. (medscape.com)

Doug Kellogg's lab is working to elucidate these mechanisms, using biochemistry, genetics, and mathematical modeling to understand signaling networks that are required for control of cell size and cell growth. (ucsc.edu)

Mice homozygous for a conditional allele activated in Schwann cells exhibit transient acceleration of postnatal myelination, reduced demyelination in culture, and reduced myelin degradation and increases remyelination following nerve axotomy or sciatic nerve crush. (jax.org)
Mice homozygous for a null allele exhibit incomplete prenatal lethality, decreased osteoclast cell number, decreased angiogenesis, increased long bone epiphyseal plate size, and short long bones. (jax.org)
At high stimulus speeds, HS cells exhibit steady-state responses during flight that are absent during quiescence, a state-dependent difference in physiology that is explained by changes in their presynaptic inputs. (caltech.edu)
Yolk syncytial layer cell nuclei exhibit convergence and extension behaviors during late gastrulation. (cellimagelibrary.org)
Despite their highly variable appearance, pleomorphic adenomas can be fundamentally regarded as a "biphasic" tumor, as their ducts and tubules exhibit two cell layers: an inner or luminal ductal cell layer, and an outer or abluminal myoepithelial cell layer. (medscape.com)

Previously, Lahav and colleagues revealed the dynamic behavior of p53 over time and how it affects cancer drug efficacy, cell fate, and more. (sciencedaily.com)

started a dissection of the behavior circuit underlying parental behavior, from brain regions to genetically-defined cell populations. (harvard.edu)
The findings, published in the May 22 issue of Nature, give a glimpse into how that collective behavior works, and show that cell populations maintain a built-in variability that nature can harness for change under the right conditions. (sciencedaily.com)
They began by examining populations of seemingly identical blood stem cells, and found that a cell marker of "stemness," a protein called Sca-1, was actually present in highly variable amounts from cell to cell -- in fact, they found a 1,000-fold range. (sciencedaily.com)
At smaller and smaller subcellular scales, the familiar concept of concentration becomes increasingly meaningless, instead replaced by the stochastic behaviors of heterogeneously distributed populations of molecules. (psc.edu)

To study PDX cells preclinically, we used both bioluminescence imaging (BLI) to evaluate cell viability and magnetic particle imaging (MPI), an emerging imaging technology to allow for detection and quantification of iron nanoparticles. (biorxiv.org)
The higher cell viability observed in the HMGB1 knocked-down group after stimulation with H 2 O 2 indicated the possible negative effect of HMGB1 on cellular lifespan. (frontiersin.org)
For MSNs-GA, cell viability was reduced as a function of incubation time and different concentrations of nanoparticles. (springer.com)
MSNs can easily internalize into Caco-2 cells without deleterious effects on cell viability. (springer.com)
The cell viability of Caco-2 cells was affected during MSNs-GA uptake. (springer.com)
In the intestine, which is normally more resistant to radiation, the addition of the drug reduced cell viability and survival. (sciencedaily.com)

Nuclei analysis demonstrated a non-directed cellular migration at planar surfaces and random fibers, different from cultures at aligned fibers where HNPCs were oriented parallel with the fibers. (diva-portal.org)
Using high-resolution time-lapse intravital imaging, tumor cell migration in the tumor core, border and invasive front was recorded. (nature.com)
Since the structural changes in cytoskeleton occur in cell migration, the "Morphology Analysis" protocol will be a useful tool for the study of the inflammatory response and also cancer metastasis. (yokogawa.com)

After gene manipulation, we further investigated the characteristics of cellular HMGB1 in HEI-OC1 cells. (frontiersin.org)
Using in situ hybridization between c-fos , an immediate early gene transiently induced by neural activity, and a number of cell markers in the MPOA, they identified the neuropeptide gene galanin ( Gal ) as a marker for the active neurons. (harvard.edu)
And again, this variability was dynamic: the differences diminished over time, with gene activity in both the low- and high-Sca-1 cells becoming more like that in the middle group. (sciencedaily.com)
Together, the findings make the case that a slow fluctuation or cycling of gene activity tends to maintain cells in a stable state, while also priming them to differentiate when conditions are right. (sciencedaily.com)
For example, AR activation by testosterone in some cell types can lead to increased expression of the FADS1 gene , which increases production of important fats2. (helix.com)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
PNKP gene mutations lead to production of an unstable enzyme that is quickly broken down in the cell. (medlineplus.gov)
which means both copies of the gene in each cell have mutations. (medlineplus.gov)
[ 7 ] In addition, recent gene expression profiling studies support the concept that radial glial cells from different neuroanatomic sites may be predisposed to acquiring particular genetic aberrations that result in ependymomas with site-specific genetic signatures and biologic potential. (medscape.com)

This knowledge is useful in future exploration of in vivo-resembling neural cell system using electrospun scaffolds. (diva-portal.org)
What is the molecular identity of the neural population involved in control of parental behavior? (harvard.edu)
Neuroethology refers to the study of the neural basis of natural behavior in animals. (scholarpedia.org)
The proteoglycan mimic facilitated this interaction and allowed the stem cells to develop into neural rosettes, which are precursors to nerve cells. (lbl.gov)
Neuroblastoma tumor initiating cells are immature with a neural crest-like phenotype and. (lu.se)

Roughly 95% of creatine is released in close proximity to the muscle tissue and transported into the cell via a limited capacity creatine-transporter system. (oatext.com)
More specifically, DAMPs include pathogen-associated molecular patterns (PAMPs) and "alarmins," endogenous molecules that signal tissue and cellular damage. (frontiersin.org)
Traditionally, neurobiologists have worked on anesthetized animals, or isolated parts of nervous tissue, or even single cells. (scholarpedia.org)
If this damage cannot be repaired, particularly to DNA, cells will self-destruct to protect the surrounding tissue and organism as a whole. (sciencedaily.com)
Airavaara's groups latest findings in Science Advances at the Institute of Biotechnology suggest that increasing the number of phagocytic cells after stroke may aid tissue recovery after stroke. (helsinki.fi)
Intra-articular HMGB1 did not induce cellular infiltration in the ankle joint suggesting its action on tissue resident cells. (iasp-pain.org)
Since natural sugars are difficult to manage, the development of proteoglycan mimics could significantly decrease the cost and complexity of tissue engineering and stem cell therapy. (lbl.gov)
Cellular adaptation to diminished tissue oxygen tensions, hypoxia, is largely governed by the hypoxia inducible transcription factors, HIF-1 and HIF-2. (lu.se)
inbook{ecf3c49f-5038-4d94-a89d-062e1056050f, abstract = {{Cellular adaptation to diminished tissue oxygen tensions, hypoxia, is largely governed by the hypoxia inducible transcription factors, HIF-1 and HIF-2. (lu.se)

Recent work has shown that these proteins are also involved in hormonal regulation of breast cancer cells. (ucsc.edu)
Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)

Cell assemblies and central pattern generators (CPGs) are related types of neuronal networks: both consist of interacting groups of neurons whose collective activities lead to defined functional outputs. (degruyter.com)
It is likely that constituent neurons in a cell assembly can be spread over large territories, intermixed with many other neurons ( Wallace and Kerr, 2010 ). (degruyter.com)
Previous studies in the Dulac lab using mice deficient in TRPC2, an ion channel specifically expressed in VNO receptor neurons and essential for VNO sensory transduction, showed that the vomeronasal pathway is critical for social interactions including inter-male aggression and sexual behavior. (harvard.edu)
Cell-type specific ablation of the MPOA Gal cells leads to parental defects in virgin females, mothers and fathers, whereas optogenetic activation of these neurons in virgin males suppressed pup-directed aggression and induces pup grooming. (harvard.edu)
These results thus establish the MPOA Gal neurons as an essential regulatory node of parenting behavior in both males and females. (harvard.edu)
Interestingly, a separate subset of Gal neurons was found activated in mating behavior, medial to those that are activated by parenting, as revealed by cellular compartment analysis of temporal activity by fluorescent in situ hybridization (catFISH) which allows direct comparison of cells activated by the two behaviors. (harvard.edu)
Accordingly, the ablation of the MPOA Gal neurons also leads to deficits in mating behavior but not in inter-male aggression. (harvard.edu)
For example, to explore the involvement of certain, anatomically defined brain areas in the control of specific behaviors it was reasonable to stimulate neurons of these areas electrically via electrodes implanted in the brain of awake, freely moving animals. (scholarpedia.org)
Here, we performed single-cell transcriptional profiling of mouse habenular neurons at critical developmental stages, instructed by detailed three-dimensional anatomical data. (nih.gov)

However, when Huang and Chang divided the cells expressing low, medium and high levels of Sca-1 and cultured them, each descendent cell population recapitulated the same broad range of Sca-1 levels over nine days or more, regardless of what levels they started with. (sciencedaily.com)
In a final step, Huang and Chang used microarrays to look at the cells' entire genome. (sciencedaily.com)
Even if cells are officially genetically identical and belong to the same clone, individual members of that population are quite different at any given time," says Huang. (sciencedaily.com)

To further investigate the physiological processes 40 underlying GBM cell movement, this study aimed to image and analyze distinct GBM invasive growth patterns found in vivo , similar to those observed in patients. (nature.com)
Understanding the potential variations in actin behavior is essential for unraveling cellular processes and diseases. (upstate.edu)
This transparent material allows the user to monitor tip elongation processes in individual cells during microgap penetration by time-lapse imaging. (jove.com)
The visualization and documentation of biological processes in real time within living cells, has rapidly gained prominence. (reportlinker.com)
We conclude that simple surrogates of dose can cause processes are expected to significantly affect the cellular dose. (cdc.gov)
We demand to characterize the hazard potential of the considerable develop these ideas by introducing the concept of cellular dose number of nanomaterials that have been or will be produced is in vitro as an important dose metric and by integrating aspects of material science, solution physics, and kinetics to present the 1 factors and processes affecting the cellular dose for particles. (cdc.gov)

In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

The conventional view of how stem cells differentiate assumes that cells are "instructed" to progress along prescribed signaling pathways. (sciencedaily.com)
A new study suggests that the conventional view, which assumes that cells are "instructed" to progress along prescribed signaling pathways, is too simplistic. (sciencedaily.com)
Immunoreceptor signaling during development, homeostasis, and effector function of T cells and NK cells. (upstate.edu)

Insight into the mechanisms and pathophysiology of breast cancer brain metastasis have long relied on the use of immortalized cell lines that have been injected intracardially into the left ventricle of the mouse heart in order to selectively grow tumours within the brain. (biorxiv.org)
By investigating the precise mechanisms of actin in different cell types, researchers aim to identify potential therapeutic targets and develop interventions to combat these diseases. (upstate.edu)
This in vitro platform can be used to study how individual cells respond to physically constrained spaces and may provide insights into tip-growth mechanisms. (jove.com)
Collectively, our work highlights sex- and cellular location-dependent roles of HMGB1 and TLR4 in peripheral pain mechanisms. (iasp-pain.org)
The volumetric analysis of cellular expression patterns provides evidence for molecular mechanisms regulating the development of pre-implantation mouse embryos. (zeiss.com)

The pathogenesis of the disease is unclear, but altered expression of cytokines and cellular adhesion molecules, important for chemotaxis of LC, are thought to be involved in its development. (medscape.com)
DNA breaks may be caused by potentially harmful molecules (such as reactive oxygen species) produced during normal cellular functions, natural and medical radiation, or other environmental exposures. (medlineplus.gov)

TEM and fluorescent microscopy confirmed the internalization of MSNs by Caco-2 cells through nonspecific cellular uptake. (springer.com)
Various mechanical properties of the pollen tube have been studied, including turgor pressure and stiffness of the cell's apical region, which can be measured using the incipient plasmolysis method 3 , 4 and cellular force microscopy (CFM) 5 , 6 , respectively. (jove.com)
To determine which cells are expressing specific cellular markers and how these cells are organized relative to each other requires volumetric imaging of the pre-implantation embryos by confocal microscopy. (zeiss.com)

And, we furtherly performed single-cell spatial transcriptomic sequencing on postnatal day 1 mouse enthesis, in order to deconvolute bone-tendon junction (BTJ) chondrocytes onto spatial spots. (elifesciences.org)
Many challenges present themselves when creating realistic cellular models, from the detailed spatial representation of membranes and organelles to convoluted biochemical pathways. (psc.edu)
Structural data required for building spatially realistic cell models, and even larger connectomics models, are particularly demanding of both resolution and spatial extent. (psc.edu)

In vitro endothelial cell adhesion experiments demonstrate that, as creatine concentrations increase, endothelial cell surface adhesion and permeability were both modified. (oatext.com)
These properties determine the adhesion and behavior of cells in contact with the surface. (bvsalud.org)

In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)

His lab seeks to understand how cortical microcircuits process sensory information to drive behavior. (berkeley.edu)
It can be used to study cortical organization and clarify brain-behavior relationships. (bvsalud.org)

Nobel Prize-winning physicist Steven Chu is the William R. Kenan, Jr., Professor of Physics, Professor of Molecular & Cellular Physiology in the Medical School and Professor of Environmental Science and Engineering in the Doerr School of Sustainability at Stanford University. (stanford.edu)

The habenula plays a key role in various motivated and pathological behaviors and is composed of molecularly distinct neuron subtypes. (nih.gov)
OBJECTIVES: To investigate if delta-radiomics features have the potential to predict the major pathological response (MPR) to neoadjuvant chemoimmunotherapy in non-small cell lung cancer (NSCLC) patients. (bvsalud.org)

Camilla Forsberg studies how the different types of blood cells develop from hematopoietic stem cells in the bone marrow. (ucsc.edu)
[ 3 , 4 ] Langerhans cells are stellate dendritic cells that arise from CD34-positive bone marrow stem cells [ 5 ] and are not a member of the mononuclear phagocytic system. (medscape.com)

It is thought that DNA damage that accumulates during development before birth leads to the death of nerve cell precursors, impairing normal brain growth and causing microcephaly and the other neurological features of MCSZ. (medlineplus.gov)

By examining the differences in behavior between isoforms, scientists hope to gain a better understanding of their distinct roles in various cells and diseases. (upstate.edu)

There is momentum towards implementing patient-derived xenograft models (PDX) in cancer research to reflect the histopathology, tumour behavior, and metastatic properties observed in the original tumour. (biorxiv.org)
While these cell lines have been well characterized, they do not represent the tumour heterogeneity, metastatic behaviours, and histopathology seen clinically, and are unsuitable for evaluating therapies due to their fast progression in vivo ( 8 , 9 ). (biorxiv.org)

The goal of this study was to develop the first successful iron labeling method of breast cancer cells derived from patient brain metastases and validate this method with imaging during tumour development. (biorxiv.org)
The CPG field is one area of study that sets the standard on how basic cellular neurophysiology determines biological function. (degruyter.com)
The switch between the two opposing behaviors raises an important and fascinating question in the study of parental interactions. (harvard.edu)
Using cell-type specific gain- and loss-of-function manipulations, a recent study by Wu et al. (harvard.edu)
Furthermore, this study has identified a genetically defined population in the medial preoptic area (MPOA) governing parental behavior. (harvard.edu)
When scientists study actin, the default has been actin synthesized from muscle cells. (upstate.edu)
For the study, the research team, led by INBT alum Quinton Smith and postdoctoral fellow Nash Rochman, placed human induced pluripotent stem cells, called hiSPCs, in patterns shaped like stars, circles, triangles, and hearts. (jhu.edu)
Often, they study the behavior of an animal in its natural habitat, avoiding disturbance by the experimenter as much as possible. (scholarpedia.org)
This collaboration allows researchers to study the intricate behavior of cellular mechanics and their influence on overall system performance. (devx.com)
In this study, the effects of intracellular delivery of various concentrations of gallic acid (GA) as a semistable antioxidant, gallic acid-loaded mesoporous silica nanoparticles (MSNs-GA), and cellular uptake of nanoparticles into Caco-2 cells were investigated. (springer.com)
A new study now finds that cellular survival after radiation exposure depends on behavior of the tumor-suppressor protein p53 over time. (sciencedaily.com)
These features allow us to study the elongation capability of tip-growing plant cells in a physically confined environment. (jove.com)
Increased adoption in health and medical applications, including the study of cellular structures and behavior under. (reportlinker.com)

To investigate the cellular basis of this effect, we performed whole-cell patch-clamp recordings from the set of identified visual interneurons [horizontal system (HS) cells] thought to control this reflex during tethered flight. (caltech.edu)
In the present work, we have isolated and characterized the extracellular vesicles from human AD-MSC to investigate their role in the chondroprotective actions of these cells. (karger.com)
We describe a method to investigate the capability of tip-growing plant cells, including pollen tubes, root hairs, and moss protonemata, to elongate through extremely narrow gaps (~1 µm) in a microfluidic device. (jove.com)
A wide range of approaches have been developed to thoroughly investigate cellular behavior on Ti surfaces. (bvsalud.org)

Growth factors guide the development of embryonic stem cells but often require proteoglycans - surface-bound sugar - to interact with the cell. (lbl.gov)

Blood stem cells with low levels of Sca-1 differentiated into red blood cell progenitors seven times more often than cells high in Sca-1 when exposed to erythropoietin, a growth factor that promotes red blood cell production. (sciencedaily.com)
But recreating this niche environment is incredibly complex in a controlled setting, because researchers are still learning all the factors that influence cell behavior and growth. (jhu.edu)
When there is no cell tension, self-organization won't happen, indicating that mechanical confinement plays an important role in cell growth and behavior. (jhu.edu)
To address this issue, we have developed growth chambers for tip-growing plant cells that contain a series of narrow, micro-fabricated gaps (~1 µm) in a poly-dimethylsiloxane (PDMS) substrate. (jove.com)
As the poly-dimethylsiloxane (PDMS) microdevices presented in this manuscript are optically transparent and air permeable, we can culture living cells inside the device and observe their growth behaviors under a microscope. (jove.com)
we applied Single-cell RNA sequencing (scRNA-seq) to delineate the comprehensive postnatal RC enthesis growth and the temporal atlas from as early as postnatal day 1 up to postnatal week 8. (elifesciences.org)

Interestingly, while the contribution of TLR4 on myeloid cells to nociception was minimal in females compared to males, TLR4 on nociceptors are important for HMGB1-induced pain in both sexes. (iasp-pain.org)

High-mobility group box 1 (HMGB1), a representative damage-associated molecular pattern (DAMP), acts as a mediator of inflammation or an intercellular messenger according to its cellular localization. (frontiersin.org)
Mechanically stimulated cells revealed a localization of FN around the cell periphery as well as an increase in FN fibril formation. (nature.com)

These results, while still perplexing, imply further functional heterogeneity within the Gal cells or an intricate interaction between various types of social behaviors. (harvard.edu)

In neuroscience research, cell culture systems are essential experimental platforms. (diva-portal.org)

In eukaryotic cells, actin filaments form cytoskeleton, a network of two types of fibrous structures, filaments and tubules. (yokogawa.com)
Cytoskeleton plays various key roles in cells such as the arrangement of cellular organelles, keeping the shape of cell, and power generation for cellular movement accompanying cell morphological changes in occasions such as cell division, muscle contraction and ciliary movement. (yokogawa.com)

Changes to ovary cells have been associated with radiofrequency radiation exposure in laboratory rats. (ewg.org)
Prenatal exposure to radiofrequency radiation in laboratory rats was associated with follicle degeneration and structural changes of ovary cells that produce estrogen. (ewg.org)
Exposure to radiofrequency radiation from cell phones was associated with the death of the uterine lining in laboratory rats. (ewg.org)
The MPOA of the anterior hypothalamus has previously been implicated in the control of maternal behavior in rats, as well as in many other brain functions such as thermoregulation and reproduction. (harvard.edu)

Tumor cell dynamics at different border configurations were analyzed and multivariate linear modelling of tumor cell spreading was performed. (nature.com)
Here, we have presented the spatiotemporal dynamics of the expression of HMGB1, exhibiting distribution variability in specific cochlear regions and cells following noise exposure. (frontiersin.org)
So, the team explored whether manipulating p53 dynamics could increase tumor vulnerability, focusing on human colon cancer cell lines with unmutated, functional p53. (sciencedaily.com)

Cells can chemically modify their histones to control which genes are turned on or off. (mskcc.org)
Instead, it supports the idea that cells differentiate through the collective behavior of multiple genes in a network that ultimately leads to just a few endpoints -- just as a marble on a hilltop can travel a nearly infinite number of downward paths, only to arrive in the same valley. (sciencedaily.com)
Again, they found tremendous variability within the apparently uniform cell population: more than 3,900 genes were differentially expressed (turned "on" or "off") between the low- and high-Sca-1 cells. (sciencedaily.com)
In prostate cells, AR regulates other genes that are important for cell duplication-a helpful behavior during embryonic development when the body needs to generate more cells to build organs. (helix.com)
Once bound with the DNA, the hormone receptors alter which genes can-and can't-be used by the cell. (helix.com)
They found that the animals exhibited improvements in behavior, that was related to an increase in the expression of specific genes in immune cells. (helsinki.fi)
K. Kokame, H. Kato and T. Miyata, "Homocysteine-Respondent Genes in Vascular Endothelial Cells Identified by Differential Display Analysis. (scirp.org)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

MRC5 cells were seeded on 96-well plates at 20,000 cells/well, cultured for 24 hours, fixed with formaldehyde and stained actin with phalloidin. (yokogawa.com)
Fixed the cells with formaldehyde and stained actin with phalloidin. (yokogawa.com)
Actin, a crucial protein involved in various cellular functions, has predominantly been studied using actin synthesized from muscle cells. (upstate.edu)
However, this approach neglects the diversity of actin present in different (non-muscle) cell types. (upstate.edu)
The problem is, not all cells have this muscle actin. (upstate.edu)
Most of the cells in our body rely on actin to do a whole lot of things," explains Haarer. (upstate.edu)

The ability of alkaline buffered creatine to produce micro-environmental remodeling, influence cell membrane behavior and impact cisplatin-mediated toxicity, are also examined in this paper. (oatext.com)
MSNs did not show significant toxicity in various concentrations (0-500 μg/ml) on Caco-2 cells. (springer.com)
Here we develop and apply the principles of their evolution from systems principally for evaluating mechanism dosimetry in vitro and outline an approach for simulation of of toxicity to high-throughput systems for rapid and cost-effective nanoparticle particokinetics in cell culture systems. (cdc.gov)

Bioengineers face the central question of regenerative medicine: what causes stem cells to grow, organize, and mature from a small population of cells to complex organs? (jhu.edu)

The pathogenesis of glioblastoma (GBM) is characterized by highly invasive behavior allowing dissemination and progression. (nature.com)
The pathogenesis of GBM is manifold and includes highly-invasive behavior that is a main cause behind GBM dissemination and progression 16 , 17 . (nature.com)
[ 3 , 6 ] The biologic behavior of LCG ranges from spontaneous remission to progressive dissemination, and such behavior cannot be predicted on the basis of histologic features. (medscape.com)

The team created micropatterned shapes, coupled with machine learning, to see how confinement influences stem cell maturation and organization. (jhu.edu)
Machine learning unveils the roles of cell density (in blue) and tension (in red) on hiPSC self-organization in micropatterned shapes. (jhu.edu)
The beginnings of modern neurobiology can be dated back to the end of the nineteenth century after the histological studies of Santiago Ramón y Cajal (1852-1934) had provided experimental evidence in favor of the cell theory as an adequate description of the organization of the nervous system. (scholarpedia.org)

These lesions as well as the rare multicentric reticulohistiocytosis (MRH), a systemic monocytoid/histiocytic disorder with multinucleated giant cells, polyarthritis, and papulonodular skin lesions, should be considered in the differential diagnosis. (medscape.com)
Langerhans cell granulomatosis (LCG) is a clonal disorder characterized by lesions containing histiocyte-like cells, giant cells, and eosinophils. (medscape.com)
Esophageal squamous precancerous lesions (ESPL) are the precursors of esophageal squamous cell carcinoma (ESCC) including low-grade and high-grade intraepithelial neoplasia. (bvsalud.org)

The in vitro GA release from MSNs-GA exhibited the same antitumor properties as free GA on Caco-2 cells. (springer.com)

however, researchers lack the methodology to visualize cellular behavior in such restrictive conditions. (jove.com)

Knockdown of HIF-2alpha in neuroblastoma and glioma tumor stem/initiating cells leads to reduced levels of VEGF and poorly vascularized, highly necrotic tumors. (lu.se)

How does a stem cell decide what specialized identity to adopt -- or simply to remain a stem cell? (sciencedaily.com)
We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)
The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)
The "stem cell" theory of tumorigenesis has it roots in the classic literature of neuropathology, dating back to early perspectives from Bailey and Cushing. (medscape.com)

Is the mechanical activity of epithelial cells controlled by deformations or forces? (crossref.org)

Through various means, prostate cancer cells may cause excessive activity from the AR protein4-6. (helix.com)

Recent reports have shown that an artificially created alkaline environment can influence cell membrane permeability and cell behavior. (oatext.com)
We recently developed a generic method for producing polymer-supported lipid bilayers directly from cell-derived native membrane vesicles (NMVs). (lu.se)
As cell membranes are both dynamic and compositionally complex, replicating these aspects in a model membrane are essential. (lu.se)

A team of scientists from the Sloan Kettering Institute led by chemical biologist Yael David reported in Nature Communications that cancer cells are especially susceptible to this type of damage. (mskcc.org)

Anatomy15

Organisms6

Diseases9

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Psychiatry and Psychology125

Phenomena and Processes54

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena23

Technology, Industry, Agriculture5

Information Science13

Named Groups5

Health Care23

Geographicals1

Differentiation18

Cell's behavior and identity2

20182

Proliferation5

Biology9

Mesenchymal6

Social behavior3

Clinical5

Tissues13

Biochemistry1

Exhibit5

Dynamic behavior1

Populations4

Viability6

Migration3

Gene10

Neural5

Tissue9

Proteins2

Neurons9

Huang3

Processes6

Regulation1

Signaling3

Mechanisms5

Molecules2

Microscopy3

Spatial3

Adhesion2

Tumor cell invasion1

Cortical2

Physiology1

Pathological2

Bone marrow2

Neurological1

Isoforms1

Metastatic2

Study13

Investigate4

Embryonic stem1

Growth6

Interestingly1

Localization2

Intricate1

Neuroscience1

Cytoskeleton2

Rats4

Dynamics3

Genes8

Actin6

Toxicity3

Regenerative medicine1

Dissemination3

Organization3

Lesions3

Vitro1

Researchers1

Poorly1

Stem cell4

Epithelial cells1

Prostate cancer cells1

Membrane3

Scientists1