Cellular adipose tissue brown. Medical search. Frequent questions

The therapeutic targeting of brown fat for the treatment of human obesity is an active research field. (wikipedia.org)
Remarkably, dietary selenium supplementation elevated facultative incorporation into UCP1, elevated energy expenditure through thermogenic adipose tissue, and protected against obesity. (nih.gov)
In obesity the inherent capacity of adipose tissue to store and sense nutrients is compromised, causing spillover of the intermediate lipid metabolites into circulation and resulting in their ectopic deposition in tissues not suitable for lipid storage, a phenomenon known as lipotoxicity. (frontiersin.org)
Along with adipocyte hypertrophy, macrophage infiltration of white adipose tissue (WAT) is associated with the pathophysiology of obesity, AD and IR, albeit the underlying molecular mechanisms are uncharacterized. (hhs.gov)
The Boudina Laboratory we are interested in understanding the molecular mechanisms involved in weight gain regulation and adipose tissue expansion in diet-induced obesity (DIO). (utah.edu)
Poster session presented at J4: Obesity and Adipose Tissue Biology, Keystone Resort, Keystone, Colorado. (utah.edu)
Quantifying Brown Adipose Tissue Thermogenesis in Obesity and Type 2 Diabetes. (usherbrooke.ca)
Tissue-specific knockout of Ahr in mature adipocytes via adiponectin-Cre exacerbates obesity while knockout in liver increases steatosis without having significant effects on obesity. (uiowa.edu)
These physiological changes mean that http://jr hc.miau.ac.ir Abstract Introduction: The importance of changing the color of white adiposities into brown is due to the fact that it can have anti - obesity and anti - diabetic effects by adjusting energ y balance (by converting storage form into energy consumption). (ac.ir)
Results: Based on our literature review, physical exercise can be effective as an adipose tissue activated agent in the prevention and treatment of obesity. (ac.ir)
HPAd from Cell Applications, Inc. have been used in multiple studies investigating the cellular basis of diabetes and obesity, as well as mechanisms of action of various drug candidates. (cellapplications.com)
In preclinical studies, Nicotinamide Mononucleotide work on mice has proved to be handy in cellular biochemical activities, management of Alzheimer's disease, age-related diabetes, complications that arise from obesity, and cardioprotection. (articlecity.com)
Researchers at the National Institutes of Health, specifically at the Institute of Diabetes and Digestive and Kidney Diseases conducted studies focused on examining the potential of brown fat as a critical element in the treatment of obesity. (chambredesucre.com)
The focus is on recapitulating BAT actions and their effects on a cellular level as potential actions in addressing obesity and other metabolism-related disorders. (chambredesucre.com)

In addition to heat produced by shivering muscle, brown adipose tissue produces heat by non-shivering thermogenesis. (wikipedia.org)
Oxidation of cysteine thiols by physiological reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose tissues. (nih.gov)
Therefore, the recognition of molecular cellular mechanisms caused by the response to sport training, especially weight training exercises and changes in white and brown adipose tissue, is one of the most important parts of the thermogenesis regulation, which requires more studies. (ac.ir)
In this regard, irisin seems to be influenced by a vari ety of sports activities and is a significant factor in the conversion of white to brown adipose tissues and can play a role in weight loss and increase the body thermogenesis. (ac.ir)
On the HF-MCD diet, the Hif-p4h-2 gt/gt mice showed more browning of the WAT and increased thermogenesis. (springer.com)
Induced browning of WAT and increased thermogenesis can also mediate protection. (springer.com)
Newborns rely on nonshivering thermogenesis to metabolize brown adipose tissue (BAT) and release energy. (nih.gov)

Most interestingly, gender-specific proteome comparison showed that male and female rats displayed differential regulation of proteins involved in muscle contraction, carbohydrate, and lipid metabolism, as well as oxidative phosphorylation and cellular stress. (karger.com)
Insulin is the hormone that regulates cellular nourishment by aiding in the absorption and metabolism of nutrients from the blood. (vitalitymagazine.com)
It can also help increase the production and metabolism of brown adipose tissues, which is crucial for burning calories. (reducedfatgirl.com)
Whilst exercise improves skeletal muscle metabolism, how the process is co-ordinated at a cellular level remains unclear. (endocrine-abstracts.org)
The circadian clock regulates metabolism and energy homeostasis in peripheral tissues by mediating activity and/or expression of key metabolic enzymes and transport systems. (huji.ac.il)
Knockouts or mutations in clock genes that lead to disruption of cellular rhythmicity have provided evidence to the tight link between the circadian clock and metabolism. (huji.ac.il)
In addition, key proteins play a dual role in regulating the core clock mechanism, as well as adipose tissue metabolism, and link circadian rhythms with lipogenesis and lipolysis. (huji.ac.il)
The more brown fat you have, the faster your metabolism is likely to be. (innosupps.com)
It works on a cellular level to IMMEDIATELY accelerate the metabolism and also increases brown adipose tissue to ensure long-term sustained results. (innosupps.com)
The researchers used genetically modified mice to observe barr1's effects on metabolism in brown adipose tissue (brown fat) and in certain neurons in the brain. (nih.gov)
Regardless of the route of exposure, chloroform is excreted from the body primarily as expired carbon dioxide, although at higher concentrations, where metabolism is saturated, appreciable levels of parent compound may be exhaled as well (Brown et al. (cdc.gov)

Recently, the role of the circadian clock in regulating the differentiation into the different adipose tissues has been investigated. (huji.ac.il)
A. SDS-PAGE (10%) profiles of total protein extracted from different adipose tissues. (inventbiotech.com)

In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling , cellular differentiation , and cell death , as well as maintaining control of the cell cycle and cell growth . (wikipedia.org)
Our laboratory is focused on (1) the understanding of the role of reactive oxygen species (ROS) in fat development in DIO in mice, and (2) to study the effect of dietary on white adipose progenitor cells proliferation and differentiation. (utah.edu)
Adipose mass can be controlled by inhibition of HPAd differentiation and increase of lypolysis. (cellapplications.com)
In this review, the role of clock proteins and the downstream signaling pathways in white, brown, and brite adipose tissue function and differentiation will be reviewed. (huji.ac.il)
Triiodothyronine (T3) and irisin (I) can modulate metabolic status, increase heat production, and promote differentiation of white adipose tissue (WAT) into brown adipose tissue (BAT). (fapesp.br)

In contrast to white adipocytes, which contain a single lipid droplet, brown adipocytes contain numerous smaller droplets and a much higher number of (iron-containing) mitochondria, which gives the tissue its color. (wikipedia.org)
Both share the presence of small lipid droplets and numerous iron-rich mitochondria, giving the brown appearance. (wikipedia.org)
It has greater variability in lipid droplet size and a greater proportion of lipid droplets to mitochondria than white fat, giving it a light brown appearance. (wikipedia.org)
The presence of various types of adipocytes (white, brown, and beige) characterized by the number/size of lipid droplets, mitochondrial density, and thermogenic capacity, further highlights how intricate is the communication of these cell-types with other metabolic tissues to sense nutrients. (frontiersin.org)
However, isolation of WAT and brown adipose tissue (BAT) is technically challenging due to their high lipid and low protein contents. (inventbiotech.com)
Due to its lipophilic character, chloroform accumulates to a greater extent in tissues of high lipid content. (cdc.gov)

The WAT of P311 knockout (KO) mice has fewer resident macrophages and decreased cellular dynamics, including decreased autophagy and apoptosis. (hhs.gov)
We will also explore key adipocyte cellular processes of apoptosis and autophagy/lipophagy, which may affect adipocyte turnover in the WAT of P311 KO mice, leading to adipocyte hypertrophy and dysfunction, and thus metabolic deregulation. (hhs.gov)
WAT browning and BAT whitening) and its effect on adipocyte function and glycemic control, as P311 KO mice are hyperglycemic. (hhs.gov)
At the cellular level, cultured cells from brown adipose tissue (BAT) of Pdgfrα-Cre Ahrfl/fl mice were more responsive than cells from controls to transcriptional activation of the thermogenic uncoupling protein 1 (Ucp1) gene by norepinephrine, suggesting an ability to burn more energy under certain conditions. (uiowa.edu)
We investigated whether inhibition of hypoxia-inducible factor prolyl 4-hydroxylase-2 (HIF-P4H-2), a key cellular oxygen sensor whose inhibition stabilizes HIF, would protect from NAFLD by subjecting HIF-P4H-2-deficient ( Hif-p4h-2 gt/gt ) mice to a high-fat, high-fructose (HFHF) or high-fat, methionine-choline-deficient (HF-MCD) diet. (springer.com)
On both diets, the Hif-p4h-2 gt/gt mice gained less weight and had less white adipose tissue (WAT) and its inflammation, lower serum cholesterol levels, and lighter livers with less steatosis and lower serum ALT levels than the wild type (WT). (springer.com)
This phenomenon was first noticed by Dr. Claudia Matthaeus in the brown adipose tissue of mice during her studies at the MDC. (azolifesciences.com)
nmrHas2 mice showed an increase in hyaluronan levels in several tissues, and a lower incidence of spontaneous and induced cancer, extended lifespan and improved healthspan. (bvsalud.org)
The most notable change observed in nmrHas2 mice was attenuated inflammation across multiple tissues. (bvsalud.org)
The researchers examined metabolic functions in mice that were modified to lack barr1 and in mice that overexpressed barr1 in brown-fat cells. (nih.gov)
These effects are similar to those observed with the brown fat barr1 mutant mice, but the difference lies in the mechanism-the presence of barr1 enables insulin to silence AgRP neurons when necessary. (nih.gov)
The current study defines the tissue-specific features of the oxidative stress-related transcriptome from 10 different tissues and organs of healthy mice. (mdpi.com)
1972). Experiments in mice, rats, and monkeys indicate that oral doses (up to 60 mg/kg) of 14C-labeled chloroform in olive oil were almost completely absorbed, as indicated by an 80-96% recovery of radioactivity in expired air, urine, and carcass (Brown et al. (cdc.gov)
On the basis of pharmacokinetic results obtained in rats and mice exposed to chloroform by inhalation, and of enzymatic studies in human tissues in vitro , in vivo metabolic rate constants (VmaxC = 15.7 mg/hour/kg, Km = 0.448 mg/L) were defined for humans (Corley et al. (cdc.gov)
The conversion of chloroform to carbon dioxide was highest in mice (80%) and lowest in squirrel monkeys (18%) (Brown et al. (cdc.gov)

The prevailing dogma is that thermogenic brown adipose tissue (BAT) contributes to improvements in glucose homeostasis in obesogenic animal models, though much of the evidence supporting this premise is from thermostressed rodents. (diabetesjournals.org)
Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity. (inventbiotech.com)

It remains to be determined whether these deposits are 'classical' brown adipose tissue or beige/brite fat. (wikipedia.org)
Adipose tissues are distinguished as white, brown, and beige (or brite), each with unique metabolic characteristics. (huji.ac.il)

The number of mitochondria in a cell can vary widely by organism , tissue , and cell type. (wikipedia.org)
[20] This finding has led to general acceptance of the endosymbiotic hypothesis - that free-living prokaryotic ancestors of modern mitochondria permanently fused with eukaryotic cells in the distant past, evolving such that modern animals, plants, fungi, and other eukaryotes are able to respire to generate cellular energy . (wikipedia.org)
The primary function of brown adipose tissue (BAT) is to use lipids to generate heat through uncoupling of oxidative phosphorylation in mitochondria. (endocrine-abstracts.org)
Cellular respiration and energy production are the two major roles of mitochondria. (integrative-medicine.ca)
Brown adipose tissue contains a higher number of mitochondria compared to white adipose tissue. (well-choices.com)
Mitochondria are the cellular powerhouses responsible for energy production. (well-choices.com)
This occurs through a substantial increase in the volume of mitochondria and metabolically active mitochondria in adipose tissue. (lu.se)

Adipocytes, the key components of the adipose tissue, have unique ability to store excess energy in the form of triglycerides, sense systemic energy demands, and secrete factors (lipids, peptides, cytokines, and adipokines) to regulate other metabolic tissues. (frontiersin.org)
This results in a spectrum of cellular dysfunction, that underlies various metabolic diseases. (frontiersin.org)
Accumulation of neutral lipids, such as triglycerides, in key insulin target tissues, has been postulated to inhibit metabolic functions, however, they are less likely to be deleterious. (frontiersin.org)
In this review, we intend to provide a perspective on ceramides and ceramide metabolites in the maintenance of adipose tissue homeostasis and how adipose tissue ceramides contribute to the development of metabolic diseases. (frontiersin.org)
The proposed project will test the central hypothesis that age- and genetic ablation-mediated P311 levels play a key role in white, brown and beige adipocyte development, plasticity and function, as well as in metabolic regulation. (hhs.gov)
Quercetin helps to convert white fat to brown fat, which increases the body's metabolic rate and the efficiency of the fat burning process. (reducedfatgirl.com)
Thus, mitochondrial adaptive cellular processes are important for physiological responses, including to nutrient availability, temperature and physical activity, and their failure leads to diseases associated with mitochondrial dysfunction such as metabolic and age-associated diseases and cancer. (nature.com)

Beige fat is the adrenergically inducible cell type that is dispersed throughout adipose tissue. (wikipedia.org)
We were first to show the presence of P311 in WAT, brown adipose tissue (BAT) and beige adipose tissue. (hhs.gov)
The resultant 'beige' fat could potentially function similarly to brown fat. (lu.se)

We derive HPAd from human subcutaneous and heart adipose tissue and cryopreserve these fibroblast-like precursor cells at the end of primary culture. (cellapplications.com)

Brown fat cells come from the middle embryo layer, mesoderm, also the source of myocytes (muscle cells), adipocytes, and chondrocytes (cartilage cells). (wikipedia.org)
Both adipocytes and brown adipocyte may be derived from pericytes, the cells which surround the blood vessels that run through white fat tissue. (wikipedia.org)
Adipose tissue consists of adipocytes that store triglycerides, which are comprised of three fatty acid molecules bound to a glycerol backbone. (well-choices.com)

Practically, you ought to combat aging by first understanding the cellular and physiological processes that play a role in the age-related conditions. (articlecity.com)
Analyses of proteins from adipose tissues are increasingly critical for understanding many physiological/pathological conditions. (inventbiotech.com)

Notably, recent studies suggest that the accumulation of sphingolipids, namely ceramides and it's metabolites, play essential roles in the development of insulin resistance in tissues such as skeletal muscle, liver and, adipose tissue in obese rodents, and humans ( 6 - 20 ). (frontiersin.org)
The intake of fructose in majority of the Hif-p4h-2 gt/gt tissues, including the liver, was 15-35% less than in the WT. (springer.com)
In the present study, we test the hypothesis that reactivation of glucocorticoids, in peripheral tissues by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), is a major determinant of exogenous Cushing s syndrome.WT, global 11β-HSD1 knockout (GKO), liver-specific 11β-HSD. (endocrine-abstracts.org)
The fatty acids are then transported to other tissues, such as skeletal muscle and the liver, to undergo further processing and oxidation. (well-choices.com)
Clocks similar to the one located in the SCN are found in peripheral tissues, such as the kidney, liver, and adipose tissue. (huji.ac.il)
and liver, 65-88 mg/kg tissue wet weight. (cdc.gov)

[10] Mitochondrial biogenesis is in turn temporally coordinated with these cellular processes. (wikipedia.org)
We demonstrate that these changes have functional impacts, as evidenced by changes in cellular respiration and mitochondrial membrane potential. (bvsalud.org)
To learn about basic mitochondrial and cellular biology, understand mechanisms of disease, and develop drugs, cell culture is indispensable. (brocku.ca)
We are currently studying white fat browning at the cellular level, by measuring mitochondrial respiration and aerobic enzyme activity, in Japanese quail. (lu.se)

It involves the activation of specialized fat cells called brown adipose tissue (BAT) and the involvement of uncoupling proteins (UCPs). (well-choices.com)
The total proteins isolated are the unbiased representation of cellular proteins in the tissue. (inventbiotech.com)
1994). The initial reaction results in the formation of a reactive intermediate, which gives off hydrochloric acid to form phosgene, which is then free to react with cellular macromolecules (including GSH, proteins, and nucleic acids) or conjugate with water to form carbon dioxide and hydrochloric acid (Ade et al. (cdc.gov)
[ 8 , 9 ] Therefore, the pathogenesis appears to involve the concomitant increase in the expression of genes for TGF-beta and extracellular matrix proteins in fibroblasts in the affected tissues. (medscape.com)

During lipolysis, the stored triglycerides are broken down into fatty acids and glycerol, which are released into the bloodstream for use as an energy source by other tissues. (well-choices.com)

As studies are limited, resident macrophages could alter adipocyte function early in adipose tissue development, a novel mechanism requiring exploration. (hhs.gov)
and controlling adipocyte cellular processes. (hhs.gov)

Conclusion: According to these studies, the expression of irisin and FNDC5 con verts white adipose into brown adipose and increases the energy consumption. (ac.ir)
Even the smallest increases of brown adipose tissue can create MASSIVE calorie burning and weight loss results. (innosupps.com)

Low dose lithium supplementation promotes adipose tissue browning and SERCA uncoupling in muscle. (brocku.ca)

Exipure Ingredients works by changing white fat into brown fat (also known as brown adipose or brown fatty acids). (signalscv.com)
An extensive array of factors govern the number of fatty acids transported by the blood to the tissues and stored there. (azolifesciences.com)
A complete lack of this protein could lead to considerably more intake of fatty acids by fat-storing cells from the cellular environment. (azolifesciences.com)
This one-of-a-kind fatty acid also quells cellular inflammation. (totalhealthmagazine.com)

Taken together, the findings of these studies suggest a mechanistic framework marked by a proinflammatory and fibrogenic cytokine response with resultant tissue inflammatory cell infiltration. (medscape.com)

Adipose tissue, especially white adipose tissue (WAT), has been recognized as an essential endocrine and inflammation organ in addition to its energy storage function. (inventbiotech.com)

UCP1 is found in the type of fat we don't want too much of, white adipose tissue. (tokibotanicals.com)

Cellular Physiology and Biochemistry (2013) 31 (2-3): 408-420. (karger.com)

Oxidative medicine and cellular longevity. (ac.ir)

The classic population of brown fat cells and muscle cells both seem to be derived from the same population of stem cells in the mesoderm, paraxial mesoderm. (wikipedia.org)
Progenitors of traditional white fat cells and adrenergically induced brown fat do not have the capacity to activate the Myf5 promoter. (wikipedia.org)
Additionally, muscle cells that were cultured with the transcription factor PRDM16 were converted into brown fat cells, and brown fat cells without PRDM16 were converted into muscle cells. (wikipedia.org)
Recent advances include the use of cocktails of compounds to reprogram somatic cells, but the characteristics and mechanisms of partial cellular reprogramming by chemicals remain unclear. (bvsalud.org)
Only a few know that there are brown fat cells working in our body, whose main function is to break down and burn blood sugar to produce energy. (chambredesucre.com)
Rather than store extra fat and calories the way white fat cells do, brown fat cells burn calories, including those they find stored in white fat tissues or white fat cells. (chambredesucre.com)
It is the substance from which the brown color of the cells is derived. (chambredesucre.com)
BAT recruitment refers to the process of converting other cells, including white fat cells into brown fat, given the right conditions and circumstances. (chambredesucre.com)
IFN-gamma activates tissue macrophages and T cells. (medscape.com)

but the point is that these beneficial effects are due to the cellular - molecular mechanism is still under discussion. (ac.ir)
A corresponding mechanism has been almost entirely overlooked in birds, likely because they lack brown fat, and conventional white fat is still considered highly inactive. (lu.se)

The current proteomic study revealed that impaired protein regulation was more prominent in the muscle tissue of female diabetic rats, which were more susceptible to STZ-induced diabetes. (karger.com)

Adipose tissue is a key nutrient-sensing depot that regulates excess energy storage and consumption. (frontiersin.org)
They are responsible for creating about 90 percent of cellular energy. (integrative-medicine.ca)
They are responsible for producing about 90 percent of cellular energy in the form of adenosine triphosphate (ATP). (integrative-medicine.ca)
As you age, cellular energy decreases due to the low levels of nicotinamide mononucleotide and subsequent reduction of NAD+. (articlecity.com)
Fat, or adipose tissue, serves as the body's primary energy storage system. (well-choices.com)
Brown Adipose Tissues or BAT, to burn energy that produces body heat has long been a target of studies by weight loss drug developers. (chambredesucre.com)

Can deep-learning algorithms identify genetic mutations or aberrant cellular signalling pathways from medical images? (usherbrooke.ca)

Notably, this is not the same as the presence of Myf5 protein, which is involved in the development of many tissues. (wikipedia.org)
Barr1 is a widely expressed cytoplasmic protein that regulates cellular responses to extracellular stimuli. (nih.gov)
High Efficiency Protein Extraction from Adipose Tissues. (inventbiotech.com)

Tissue-specific responses to oxidative stressors reflect the organ-related variable vulnerability to chronic diseases, including cancer and age-related disorders. (mdpi.com)
These results will serve as a reference for animal models and help to advance our understanding of tissue-specific variability in oxidative stress-associated pathogenesis. (mdpi.com)

These adaptive molecular and structural mechanisms increase respiration to maintain basic processes specific to cell types and tissues. (nature.com)

Nedergaard, J. & Cannon, B. Brown adipose tissue as a heat-producing thermoeffector. (nature.com)

What Exactly are Brown Fats? (chambredesucre.com)
The Exipure formulation combines natural ingredients that promote the recruitment of brown fats as a way to boost their occurrences throughout the body. (chambredesucre.com)

Cellular and Molecular Life Sciences. (lu.se)

One of the characteristics of exercise effects is the conversion of white adipose tissue i nto brown adipose tissue. (ac.ir)

Brown adipose tissue is especially abundant in newborns and in hibernating mammals. (wikipedia.org)

Cellular Components of the Immune System The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)

In general, the pathophysiology underlying eosinophilic fasciitis is postulated to involve an inflammatory response resulting in an activated inflammatory cell infiltrate of affected tissues and subsequent dysregulation of extracellular matrix production by lesional fibroblasts. (medscape.com)

Effect of Notoginsenoside R1 on autologous adipose graft in rats. (inventbiotech.com)
Finally, the nasal lesions associated with exposure to high concentrations of MeI in rats are best supported by a mode of action that involves glutathione (GSH) depletion in the nasal epithelial tissue. (cdc.gov)

Drug-mediated activation of Gi signaling in fat tissue may prove beneficial for reducing elevated blood-glucose levels in type 2 diabetes," said Wess. (nih.gov)

The presence of brown adipose tissue in adult humans was discovered in 2003 during FDG-PET scans to detect metastatic cancers. (wikipedia.org)
Brown fat in humans in the scientific and popular literature refers to two cell populations defined by both anatomical location and cellular morphology. (wikipedia.org)
While we know that white fat can be 'browned' in various studies on humans and other mammals, the situation in birds remains entirely unknown. (lu.se)

In the first study, Wess's group found that barr1 is critical in maintaining the proper function of brown fat, which metabolizes nutrients to create body heat. (nih.gov)

Further, we will investigate the role of P311 in cellular processes (i.e. (hhs.gov)

This facultative utilization of selenium was initiated by increasing cellular levels of organic, but not inorganic, forms of selenium. (nih.gov)
Its formula includes ingredients that help raise the levels of brown adipose tissue (BAT). (reducedfatgirl.com)
Inversely, lean people had higher levels of brown adipose tissue. (innosupps.com)
Brown fat can burn up to 300 times more calories than any other cell in your body and helps make your body substantially more efficient at losing body fat and maintaining low body fat levels. (innosupps.com)
Fibroblasts from lesional tissue of patients with eosinophilic fasciitis produce excess collagen in vitro and display elevated TGF-beta and type 1 collagen mRNA levels when examined via in situ hybridization with specific cDNA. (medscape.com)

These supply the tissue with oxygen and nutrients and distribute the produced heat throughout the body. (wikipedia.org)

Following oral exposure in animal studies, distribution of chloroform appears to be similar to following inhalation exposure, with the primary concentrations in lipophilic tissues (Brown et al. (cdc.gov)

Exipure Ingredients a natural dietary supplement that promotes healthy weight loss through the conversion of white fat to brown fat. (signalscv.com)
Qsymia is an information that is popular and produced, chromium vanadium dietary supplement but some of the brown adipose tissue absorbs. (e-phunk.com)

Anatomy32

Organisms18

Diseases30

Chemicals and Drugs99

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Psychiatry and Psychology3

Phenomena and Processes54

Disciplines and Occupations1

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Different adipose tissues2

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