Cells with hemangioblast. Medical search. Frequent questions

These parent stem cells, ESCs, give rise to progenitor cells, which are intermediate stem cells that lose potency. (wikipedia.org)
Vasculogenesis is new production of a vascular network from mesodermal progenitor cells. (wikipedia.org)
Important signaling factors for vasculogenesis are TGF-β, BMP4, and VEGF, all of which promote pluripotent stem cells to differentiate into mesoderm, endothelial progenitor cells, and then into mature endothelium. (wikipedia.org)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
Subsequent studies with hESC-derived endothelial progenitor cells decreased MI size and improved LV function in a mouse model of myocardial ischemia. (ca.gov)
Studies are in progress to improve the efficiency and effectiveness of hESC-derived endothelial progenitor cells to create new blood vessels. (ca.gov)
In fetal liver and adult bone marrow, Tie-2 is expressed by a subpopulation of hematopoietic progenitor cells characterized as Lineage markers^-, c-Kit^+, Sca1^+ cells. (thermofisher.com)
Early fate decisions in hematopoietic stem and progenitor cells. (lu.se)
In the present study, we demonstrate that functional CD34 + progenitor cells can be efficiently produced from human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) by combined modulation of 2 signaling pathways. (ashpublications.org)
hPSC-derived CD34 + progenitor cells further developed to endothelial and smooth muscle cells with functionality. (ashpublications.org)
Our results suggest that combined modulation of signaling pathways may be an efficient means of differentiating hPSCs into functional CD34 + progenitor cells. (ashpublications.org)
Diabetes is known to impair the number and function of endothelial progenitor cells in the circulation, causing structural and functional alterations in the micro- and macro-vasculature. (biomedcentral.com)
Based on review of current literature, this study examined the expression level of 35 genes that are known to be involved in endothelial progenitor cell migration and function in magnetically sorted Lin - /VEGF-R2 + endothelial progenitor cells obtained from the bone marrow of Akita mice in the early stages of diabetes (18 weeks) using RT-PCR and Western blotting. (biomedcentral.com)
We observed a significant increase in the number of Lin - /VEGF-R2 + endothelial progenitor cells within the bone marrow in diabetic mice compared with non-diabetic mice. (biomedcentral.com)
Two genes, SDF-1 and SELE, were significantly differentially expressed in diabetic Lin - /VEGF-R2 + endothelial progenitor cells and six other genes, CAV1, eNOS, CLDN5, NANOG, OCLN and BDNF, showed very low levels of expression in diabetic Lin - /VEGF-R2 + progenitor cells. (biomedcentral.com)
Low SDF-1 expression may contribute to the dysfunctional mobilization of bone marrow Lin - /VEGF-R2 + endothelial progenitor cells, which may contribute to microvascular injury in early diabetes. (biomedcentral.com)
Development of the dorsal aorta is a key step in the establishment of the adult blood-forming system, since hematopoietic stem and progenitor cells (HSPCs) arise from ventral aortic endothelium in all vertebrate animals studied. (bvsalud.org)
All mature blood cell types in the adult animal arise from hematopoietic stem and progenitor cells (HSPCs). (bvsalud.org)
This review will examine the clinical potential of several stem and progenitor cells that may be utilised to regenerate defunct or damaged vasculature and restore blood flow to the ischaemic tissue. (biomedcentral.com)
In particular, we focus on the therapeutic potential of endothelial progenitor cells as an exciting new option for the treatment of ischaemic diseases. (biomedcentral.com)
Myeloid Progenitor Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "Myeloid Progenitor Cells" by people in this website by year, and whether "Myeloid Progenitor Cells" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Myeloid Progenitor Cells" by people in Profiles. (uchicago.edu)
Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia. (uchicago.edu)

For example, an endothelial progenitor cell (EPC) is more specialized than an ESC, and an EC is more specialized than an EPC. (wikipedia.org)
The aim of this study was to identify early diabetes-related changes in the expression of genes that have been reported to be closely involved in endothelial progenitor cell migration and function. (biomedcentral.com)

Fibroblast growth factor (Fgf) has been implicated in the control of heart size during development, although whether this is by controlling cell fate, survival or proliferation has not been clear. (ox.ac.uk)
Here, we show that Fgf, without affecting survival or proliferation, acts during gastrulation to drive cardiac fate and restrict anterior haemangioblast fate in zebrafish embryos. (ox.ac.uk)
It is well established that insulin-like growth factor (IGF) signaling is important for cell responses such as mitogenesis, cell growth, proliferation, angiogenesis, and differentiation. (wikipedia.org)
The TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursors. (nih.gov)
Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. (thermofisher.com)
Loss of the wild-type allele results in VHL deficiency and the potential formation of cerebellar hemangioblastomas, which resemble embryonic hemangioblast proliferation and differentiation processes. (gwu.edu)
Angiogenesis starts from local destruction of the wall of preexisting blood vessel, activation of endothelial cell proliferation, and migration. (samploon.com)

We portrayed the Notch system in embryonic stem cell (ESC)-derived embryoid bodies (EBs) differentiating under the standard protocols used to assess yolk sac (YS) hematopoiesis in vitro. (karger.com)
A member of the tyrosine kinase receptor family, Tie-2 is expressed on endothelial and a subset of hematopoietic cells and is believed to play a role in both angiogenesis and hematopoiesis during development of the mouse embryo. (thermofisher.com)
Our data suggest that zebrafish Runx1 functions in both blood and vessel development at the hemangioblast level, and contributes to both primitive and definitive hematopoiesis. (biologists.com)
The yolk sac is the first site of blood cell production during mouse and human ontogeny and contributes to subsequent erythropoiesis, hematopoiesis and vascular development for the whole embryo. (northwestern.edu)

After the in vitro differentiation of these embryonic stem cells to embryoid bodies, developing mesodermal progenitors could be separated from those with neuroectoderm potential based on GFP expression. (elsevierpure.com)
These cells are progenitors of endothelial cells found in bone marrow (for nomenclature see also: Medina et al, 2017). (copewithcytokines.org)
In this study, neuronal progenitors occupying the molecular layer were investigated as tumor cells of origin. (gwu.edu)
Rather, cerebellar DASEs and hemangioblastomas were immunoreactive with antibody PAX2 (paired box 2), a marker of basket/stellate cell progenitors. (gwu.edu)
During embryonic development mesodermal differentiate into endothelial cells, hemangioblast and hematopoietic progenitors give rise to blood vessel, the vasculogenesis. (samploon.com)
It is as yet unresolved whether these first HSCs are derived from intraembryonic hemangioblasts, hemogenic endothelial cells, or other progenitors. (ox.ac.uk)
In vascular medicine, various stem cells and adult progenitors have been highlighted as having a vasoreparative role in ischaemic tissues. (biomedcentral.com)

The hematopoietic and endothelial lineages derive from mesoderm and are thought to develop through the maturation of a common progenitor, the hemangioblast. (elsevierpure.com)
To investigate the developmental processes that regulate mesoderm induction and specification to the hemangioblast, we generated an embryonic stem cell line with the green fluorescent protein (GFP) targeted to the mesodermal gene, brachyury. (elsevierpure.com)
Co-expression of GFP with the receptor tyrosine kinase Flk1 revealed the emergence of three distinct cell populations, GFP - Flk1 - , GFP + Flk1 - and GFP + Flk1 + cells, which represent a developmental progression ranging from pre-mesoderm to prehemangioblast mesoderm to the hemangioblast. (elsevierpure.com)
Since these cells come from the mesoderm, it can become a wide variety of different things found in many different parts of the body. (wikipedia.org)
Another difference major difference between the two formation processes is that vasculogenesis originates from hemangioblasts, which come from the mesoderm. (wikipedia.org)
Not only is VEGF critical for mesoderm cells to become an EC, but also for EPCs to differentiate into mature endothelium. (wikipedia.org)
2 It is thought that ECs originate from mesoderm-derived angioblasts and hemangioblasts during embryonic and adult development. (beckman.com)
Classic studies in the chick embryo showed that paraxial mesoderm generates a subset of somite-derived endothelial cells (SDECs) that incorporate into the dorsal aorta to replace HSPCs as they exit the aorta and enter circulation. (bvsalud.org)
While this role has been best documented in the developmental migration of the neural crest and mesoderm, here we expand on previously reported preliminary findings that morpholino knock-down of snai2 impairs the generation of hematopoietic stem cells (HSCs) during zebrafish development. (bvsalud.org)
The yolk sac is a bilayer structure of mesoderm- and endoderm-derived cell layers. (northwestern.edu)

Rat stem-cell leukemia gene expression increased during testis maturation. (nih.gov)
Vessel development involves generating primary vascular endothelial tubes by aggregation of angioblasts (vasculogenesis), creating a vascular network through endothelial sprouting (angiogenesis), and pruning primary vascular tubes by recruiting smooth muscle cells to the vessel walls (vessel maturation). (chinagene.cn)

Although several factors such as vegf, flk1, cloche, lycat and estrp are essential for angioblast development, much of the signaling pathways underlying the derivation of angioblasts from the hemangioblasts or Flk1+ mesodermal cells remain unknown. (chinagene.cn)

However, we show that the cardiac regulator nkx2.5 can also repress the haemangioblast programme and, furthermore, that cardiac specification still requires Fgf signalling even when haemangioblast regulators are independently suppressed. (ox.ac.uk)
We previously identified binding motifs for the commonly expressed AP-1 transcription factor family in open chromatin regions specific for early stages of blood specification and thus aimed to study the role of AP-1 for hemangioblast differentiation. (nih.gov)

Angioblast, the endothelial progenitor, is generated from hemangioblasts that are derived from the Flk1+ mesodermal cells, or directly from the Flk1+ mesodermal cells. (chinagene.cn)
Ligand-dependent development of the en-dothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2. (chinagene.cn)
Notch signaling is used repeatedly and with different outcomes in the lineage of mesodermal cells that leads to the production of endothelial and hematopoietic cells the so-called hemangioblasts. (fqclsb.net)

Here, we profile the transcriptome of the earliest detectable endothelial cells (ECs) during zebrafish embryogenesis to demonstrate that tissue-specific EC programs initiate much earlier than previously appreciated, by the end of gastrulation. (bvsalud.org)
Zebrafish runx1 is expressed in hematopoietic and neuronal cells during early embryogenesis. (biologists.com)

Primordial endothelial cells specialize into tissue-specific phenotypes of arterial, venous, hemogenic, and lymphatic subtypes with distinct functions for vascular development. (beckman.com)

Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
Mechanistically, in vitro data support these findings, as co-culture of hESC-MSCs with lipopolysaccharide (LPS)-stimulated BWF1 lymphocytes decreased lymphocyte secretion of TNFα and IL-6 and enhanced the percentage of putative regulatory T cells. (nature.com)
And it's not for the reason many people might think, namely the controversy over U.S. federal funding of human embryonic stem cell (hESC) research. (genengnews.com)
In addition to the cells ' potential use for the treatment of liver disease, hESC-derived hepatocytes could also provide a valuable model for novel pharmaceutical drug discovery assays as well as new drug metabolism and cytotoxicity screens, particularly because the liver is a major site for detoxification. (news-medical.net)
In an animal model of acute liver injury, the hESC-DE cells differentiated into hepatocytes and successfully repopulated the damaged liver. (news-medical.net)
Our results demonstrate that human embryonic stem cell (hESC)-derived hemangioblasts can create new blood vessels and improve blood flow in a rodent model of myocardial infarction. (ca.gov)

We conclude that Fgf controls cardiac and haemangioblast fates by the simultaneous regulation of haemangioblast and cardiac regulators. (ox.ac.uk)
The production of terminally differentiated cells from such cells, therefore, requires successive changes of cell fates, meaning that genes relevant for the next stage of differentiation must be switched on and genes not relevant anymore must be switched off. (amegroups.org)
What started as a series of microscopic observations in different animal model systems has since evolved into studies of gene expression and regulation, and subsequent protein-protein interactions, cell surface protein expression profiling, and functional mapping of cell fates. (biomedcentral.com)
Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1. (uchicago.edu)

These cells , often simply referred to as blasts , are devoid of any definitive characteristics that would mark them as belonging to any of the known hematopoietic lineages . (copewithcytokines.org)
Hematopoietic stem cells are formed during embryonic development, and serve as the foundation of the definitive blood program for life. (bvsalud.org)

These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
In older references these cells may be referred to as vasofactive cells or vasoformative cells , reflecting their role in angiogenesis . (copewithcytokines.org)
air effective roles in cell adhesion, migration, in vivo angiogenesis and tumor advancement 35, 36. (upb.ro)
MicroRNA-126 (miR-126) is endothelial cell (EC) specific and plays a key role in regulating EC function, controlling angiogenesis, and maintaining vascular integrity. (justia.com)
Cells for vascular therapy must be able to home to ischaemic or damaged tissue and engage in vessel formation alone or in unison with resident vasculature to achieve a controlled and functional reperfusion event, without causing pathological angiogenesis (for example, proliferative retinopathy in the vitreous of the eye). (biomedcentral.com)

Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
The emergence of the first adult hematopoietic stem cells (HSCs) during mammalian ontogeny has been under intense investigation. (ox.ac.uk)
Further studies in mice by Cumano and colleagues sought to address the issue of an anatomical origin of the long-term (LT) reconstituting hematopoietic stem cell (HSC) found in adult animals [ 10 ]. (biomedcentral.com)

They are multipotent, which describes the ability to give rise to many cell types, whereas a pluripotent stem cell can give rise to all types. (wikipedia.org)
However, all developmental processes originate from pluripotent precursor cell types. (amegroups.org)
Differentiation of human pluripotent stem cells (hPSCs) into functional cell types is a crucial step in cell therapy. (ashpublications.org)
We have used RT-PCR to screen pluripotent murine embryonic stem cells to identify receptor tyrosine kinases (RTKs) potentially involved in the determination or differentiation of cell lineages during early mouse development. (silverchair.com)
The future direction of the study of hematopoietic stem cells will probably make use of pluripotent stem cells to yield specific immune cell lineages and eventual clinical applications. (biomedcentral.com)

We have established a highly-efficient method for deriving hepatocytes from stem cells that mirrors events in embryonic development, " said Robert Lanza, M.D., Chief Scientific Officer at Advanced Cell Technology, Inc. and senior author of the study. (news-medical.net)
Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development. (chinagene.cn)
F-J ) Cross sections through different stages of embryonic development corresponding to the embryos shown in A-D. The mouse Isl1- en (green, GFP) and control pCAAG-RFP (red). (elifesciences.org)

This monolayer of cells acts as a barrier to separate the vascular lumen from surrounding tissues and regulates the passage of fluid and nutrients between the two. (beckman.com)

CD326 mediates calcium-independent, homophilic, cell-cell adhesion and may function as a growth factor receptor. (thermofisher.com)
Cell-to-cell signalling is induced by specific ligands such as growth factors which activate their cognate receptor molecules. (amegroups.org)
EnSCs synthesize and discharge several growth factors including transforming growth factor-α (TGFα), epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I). IGF-I, TGFα, epidermal growth factor receptor (EGFR), basic fibroblast growth factor (bFGF), and platelet derived growth factor-β (PDGFβ) receptor expression in epithelial cells are upregulated during expeditious growth in the proliferative stage. (samploon.com)

ESCs will eventually produce endothelial cells (ECs), which create the thin-walled endothelium that lines the inner surface of blood vessels and lymphatic vessels. (wikipedia.org)
Role of insulin-like growth factors in endothelium differentiation ECs derived from stem cells are the beginning of vasculogenesis. (wikipedia.org)
Endothelial cells (ECs) form the endothelium, a layer of single-cell thickness that coats the interior wall of all blood vessels including arteries, capillaries, and veins. (beckman.com)
Immunohistology of aorta-gonads-mesonephros (AGM) regions show that GFP(+) cells are specifically localized to the endothelial layer lining the wall of the dorsal aorta but not to the mesenchyme, strongly suggesting that HSC activity arises within a few cells within the endothelium of the major vasculature. (ox.ac.uk)

Snail2 is a zinc-finger transcription factor best known to repress expression of genes encoding cell adherence proteins to facilitate induction of the epithelial-to-mesenchymal transition. (bvsalud.org)

Widespread Notch1 activation was evident at days 2-4 of EB differentiation, the time window of hemangioblast generation in this in vitro system. (karger.com)
Embryonic blood cell development occurs via well-defined developmental stages which are recapitulated in vitro by differentiation of embryonic stem cells. (nih.gov)
Un rôle majeur des prostaglandines dans l'hématopoïèse, ainsi mis en évidence, a pu être étendu à la souris chez qui un traitement par la prostaglandine PGE2 provoque la multiplication des CSH in vivo et in vitro, un résultat qui génerera très probablement des applications cliniques. (hypotheses.org)

The stimulus for the change of cell fate originates from extrinsic signals which set a cascade of intracellular processes in motion that eventually terminate at the genome leading to changes in gene expression and the development of alternate gene regulatory networks. (amegroups.org)
Single-cell analysis of mixed-lineage states leading to a binary cell fate choice. (uchicago.edu)

Human embryonic stem cells (hESCs) derived from an early embryo can self-renew indefinitely and differentiate into a variety of cell types. (ashpublications.org)

The further specialized a cell is, the more differentiated it is and as a result it is considered to be more committed to a certain cellular lineage. (wikipedia.org)
The differentiation process was largely uniform with cell cultures progressively expressing increasing numbers of hepatic lineage markers. (news-medical.net)

In the developing embryo, TFs regulating the assembly/disassembly of transcriptional complexes and ultimately gene expression, are directed by complex extrinsic signalling processes which connect all cells within a multi-cellular organism to their environment. (amegroups.org)

Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators. (ox.ac.uk)
The haemangioblast programme was thought to be activated before the cardiac programme and is repressive towards it, suggesting that activation by Fgf of the cardiac programme might be via suppression of the haemangioblast programme. (ox.ac.uk)
Additionally, we have demonstrated that extracellular matrix derived peptides can recruit endogenous cardiac stem cells. (ca.gov)
Migration of Nkx2-5 -en + cells from outside the cardiac crescent towards the heart tube. (elifesciences.org)
A single cell (white arrow and circle) migrating from the border of the extraembryonic/LPM and the cardiac heart field into the developing heart. (elifesciences.org)

TAL-1 modulates the angiogenic response of endothelial cells by stimulating cell morphogenesis and by influencing their behavior in migration. (avivasysbio.com)

Endothelial cells can be found throughout the whole vascular system and they also play a vital role in the movement of white blood cells ECs were first thought to arise from extraembryonic tissues because blood vessels were observed in the avian and mammalian embryos. (wikipedia.org)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Cells Tissues Organs (2011) 193 (4): 239-252. (karger.com)
Endothelial cells form a semi-permeable barrier between the blood and surrounding tissues within all blood vessels in the body. (beckman.com)
The DNA within the nuclei of our cells carries the information to generate the machinery of the cell, the cell itself, our tissues and then the whole human. (birmingham.ac.uk)
HSPC arterial amplification occurs prior to seeding of secondary hematopoietic tissues and proceeds, in part, through the cell cycle regulator myca (c-myc). (bvsalud.org)
Noncancerous tumors are named for the specific cells or tissues in which they originate. (msdmanuals.com)
The evaluation of the most suitable timing of cell delivery as well as the number of cells needed to integrate into resident vasculature and promote revascularisation of specific tissues requires careful optimisation and evaluation. (biomedcentral.com)

Considerable time and effort has been spent in developing targeted therapies to fight SLE, yet only one therapy, belimumab (Benlysta), a monoclonal antibody targeting B cell-activating factor, or BAFF, has been approved for the treatment of SLE in the last half-century 16 . (nature.com)
Neuralstem has also entered into collaborations in Taiwan, including one with China Medical University & Hospital, to advance development of its human spinal cord neural stem cell therapies for amyotrophic lateral sclerosis. (genengnews.com)
This regenerative capacity is due to presence of EnSCs that were demonstrated to be immuno-privileged in comparison with other cell types, shedding a new light for cell-based therapies and rendering these cells as a promising resource in regenerative medicine. (samploon.com)
Without limitation, some embodiments comprise methods, systems, and/or compositions relating to microRNAs and/or cell based therapies and the use of the same in the research, diagnosis, or treatment of injury or disease. (justia.com)

Endothelial stem cells (ESCs) are one of three types of stem cells found in bone marrow. (wikipedia.org)

While ER Clark first reported the observation of vascular generation in tadpoles in 1909, and Stockard described blood-vessel development and coined the term angioblast in fish embryos in 1915, it was not until 1920 that F Sabin described the formation of blood cells through the angioblast 'liquefying' within the aorta [ 1 - 3 ]. (biomedcentral.com)
For example, hemangioblastomas originate in blood vessels ("hema" refers to blood vessels, and hemangioblasts are the cells that develop into blood vessel tissue). (msdmanuals.com)

Professor Ma heads the Blood, Stem Cell and Cancer Research Programme at St Vincent's Centre for Applied Medical Research, Sydney. (edu.au)

Unlike hemangioblastomas, however, cerebellar DASEs do not express brachyury, a mesodermal marker for hemangioblasts. (gwu.edu)

The use of cell therapy for vascular regeneration offers an exciting new prospect in regenerative medicine. (biomedcentral.com)

Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Tissue regeneration approach using stem cells in different clinical settings is a medical sensation now-a-days. (samploon.com)
Leukemia inhibitory factor (LIF), Hepatocyte growth factor (HGF) and stem-cell factor (SCF) have the essential contribution in endometrial regeneration. (samploon.com)

Applications Tested: The TEK4 antibody has been tested by blocking of staining with fluorochrome conjugated TEK4 on mouse bone marrow cells. (thermofisher.com)
A higher proportion of CD34 + cells (∼ 20%) could be derived from hPSCs by inhibition of mitogen-activated protein kinase (MAPK) extracellular signal-regulated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling and activation of bone morphogenic protein-4 (BMP4) signaling. (ashpublications.org)

Moreover, the research represents another one of Advanced Cell Technology ' s efforts aimed at the large-scale differentiation of human embryonic stem cells (hESCs) into critical replacement cell types. (news-medical.net)

CD326 is expressed on the majority of epithelial cells, and is considered a pan-carcinoma antigen. (thermofisher.com)
Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. (thermofisher.com)

Cytori Therapeutics has won both initial and expanded indication approval in Europe for its Celution® system family of medical devices and instruments, which is not yet available in the U.S. Celution extracts and separates stem and regenerative cells from a patient's own adipose tissue. (genengnews.com)
During menstruation, all these cells could be found as menstrual stem cells or endometrial regenerative cells (ERC). (samploon.com)

This study represents an important step in the development of a commercially scalable and efficacious cell therapy for SLE/LN. (nature.com)
Notch receptors and Notch ligands were detected in virtually all cells throughout EB development. (karger.com)
The development of the hematopoietic system has long served as model to understand how changes in gene regulatory networks drive the differentiation of the various blood cell types. (amegroups.org)
Vascular endothelial cell development and underlying mechanisms[J]. HEREDITAS, 2012, 34(9): 1114-1122. (chinagene.cn)
VHL cerebellar cortices also revealed PAX2-positive cells in Purkinje and molecular layers, resembling the histological and molecular development of basket/stellate cells in postnatal non-VHL mouse and human cerebella. (gwu.edu)
Some noncancerous tumors originate in cells of the embryo (embryonic cells), early in the development of the fetus. (msdmanuals.com)

These tumors originate in the cells within or next to the brain. (msdmanuals.com)

Especially Mesenchymal Stem cells have been focused in a plethora of preclinical and clinical experiments over the five decades due to extraordinary capacity in differentiation to multiple lineages, immunomodulation and angigenic properties. (samploon.com)
Large body of data of experiment concludes that EMSCs have the ability to differentiation in multiple lineages such as osteoblast, cartilage, adipose, smooth muscle cell(1/18), hepatocytes, cardiomyocyte, neural cells. (samploon.com)

Stem Cell Research Advances , edn. (edu.au)
That reflects both high population concentrations as well as the willingness by national governments to invest in stem cell research as well as companies commercializing such treatments and encourage additional research by outside parties. (genengnews.com)

However, the inability to manufacture large quantities of functional cells from a single donor as well as donor-dependent variability in quality limits their clinical utility. (nature.com)
I am delighted with the tremendous progress our scientists are making to generate a variety of important functional cells types and refine our cell differentiation process, " stated William M. Caldwell IV, CEO and Chairman of Advanced Cell Technology. (news-medical.net)

His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
By year-end the firm plans to start a clinical trial in China focused on transplantation of cells into the brain to treat stroke. (genengnews.com)

We have demonstrated that antibodies can direct stem cells to injured myocardial tissue. (ca.gov)
Human endometrial tissue composed of epithelial stem cells (0.22%), mesenchymal stem cells (1.25%) and side population stem cells. (samploon.com)
If the underlying ischaemia is not sufficiently resolved it can lead to tissue damage, with subsequent cell death. (biomedcentral.com)
This leads to hypoxia and tissue damage as a consequence of the build up of waste metabolites and may result in cell death [ 1 ]. (biomedcentral.com)
A cell therapy approach should be aimed at promoting revascularisation of ischaemic tissue. (biomedcentral.com)
There is a therapeutic window in which to deliver the cells, to avoid extensive tissue damage, fibrosis and necrosis. (biomedcentral.com)

Anatomy14

Organisms1

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes5

Information Science1

Progenitor cells25

Endothelial prog2

Proliferation7

Hematopoiesis4

Progenitors7

Mesoderm10

Maturation2

Angioblasts1

Specification2

Mesodermal cells3

Zebrafish2

Hemogenic1

HESC6

Fates4

Definitive2

Angiogenesis6

Adult4

Pluripotent5

Embryonic development3

Regulates1

Receptor3

Endothelium4

Repress1

Vitro3

Fate2

Differentiate1

Lineage2

Processes1

Cardiac5

Morphogenesis1

Tissues8

Therapies4

Found in bone marrow1

Vessel2

Programme1

Brachyury1

Vascular regeneration1

Regeneration3

Bone2

Differentiation of human1

Epithelial cells2

Regenerative cells2

Development6

Originate1

Lineages2

Stem cell res2

Functional2

Transplantation2

Tissue6