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Stem CellsHematopoietic Stem CellsStem Cell TransplantationEmbryonic Stem CellsAdult Stem CellsPluripotent Stem CellsHematopoietic Stem Cell TransplantationStem Cell NicheNeural Stem CellsInduced Pluripotent Stem CellsCell DifferentiationMultipotent Stem CellsMesenchymal Stem Cell TransplantationStem Cell FactorMesenchymal Stromal CellsCell LineageStem Cell ResearchPlant StemsFetal Stem CellsCell ProliferationCells, CulturedHematopoietic Stem Cell MobilizationNeoplastic Stem CellsBone Marrow CellsRegenerationOctamer Transcription Factor-3Cell Culture TechniquesRegenerative MedicineCell SeparationTransplantation, AutologousHematopoiesisPeripheral Blood Stem Cell TransplantationTotipotent Stem CellsAntigens, CD34Transplantation, HomologousFlow CytometryMice, Inbred C57BLEmbryo, MammalianSOXB1 Transcription FactorsSpermatogoniaSignal TransductionColony-Forming Units AssayCell- and Tissue-Based TherapyMice, SCIDTissue EngineeringGene Expression Regulation, DevelopmentalProto-Oncogene Proteins c-kitCord Blood Stem Cell TransplantationNestinCell LineReverse Transcriptase Polymerase Chain ReactionGene Expression ProfilingGerm CellsHomeodomain ProteinsHair FollicleBrain StemEmbryo ResearchPhenotypeCell SurvivalBiological MarkersCoculture TechniquesMice, TransgenicBone Marrow TransplantationNeuronsCell DivisionCell DedifferentiationModels, BiologicalFetal BloodImmunohistochemistryTranscription FactorsGreen Fluorescent ProteinsTransplantation ConditioningBone MarrowTeratomaAntigens, CDGene Expression RegulationEmbryoid BodiesNuclear ReprogrammingSpheroids, CellularCell TransplantationNeurogenesisTime FactorsChondrogenesisLentivirusGraft vs Host DiseaseCell MovementMice, Inbred NODCell TrackingGranulocyte Colony-Stimulating FactorAntigens, CD24Tissue ScaffoldsDental PulpTransplantation, HeterologousLimbus CorneaeEmbryonal Carcinoma Stem CellsGene ExpressionCell CountStage-Specific Embryonic AntigensAdipogenesisHematologic Neoplasms
Pluripotent stemProgenitor cellTransplantationBiologyTissueDerived from embryonic stemTherapyStromal cellsEndothelial cellsTherapiesMSCsVitroRegenerationAbstractTherapeuticAdultIPSCDifferentiateProliferation2023TissuesNeuralRegenerativeLineages2021MechanismsHeterogeneityGeneGenesDifferentiation of stem2016CD34MolecularHSCsLymphocytesEmbryonic cellProgenitorsMultipotentPluripotencyNeuronalGraftsGenomicTransplantsDonorMouse embryonicResearchScientistsReplenishEpithelialMiceDopamine neuronsBreakthroughMarkersInnateLund UniversityPeripheral blood
Pluripotent stem15
Progenitor cell5
  • Rare hematopoietic stem and progenitor cell (HSPC) pools outside the bone marrow (BM) contribute to blood formation under stress and illness, but their functions are unknown. (physiciansweekly.com)
  • Therefore, identifying crucial transcriptional and signaling networks that govern stem/progenitor cell function of the SG are much needed to facilitate targeted stem cell and regenerative-based therapies. (grantome.com)
  • However, our current knowledge of the molecular mechanisms by which ?Np63 directs gene expression programs necessary for the commitment, maintenance and differentiation of the stem/progenitor cell population in the SG is lacking. (grantome.com)
  • Such systematic studies are much needed as they will identify for the first time, the functional role of p63 in SG development and in orchestrating stem/progenitor cell differentiation programs. (grantome.com)
  • Human induced pluripotent stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC)-based cell transplantation has emerged as a groundbreaking method for replacing damaged neural cells and stimulating functional recovery, but its efficacy is strongly influenced by the state of the injured spinal microenvironment. (biomedcentral.com)
Transplantation15
  • Prof. Parmar and colleagues showed that following transplantation, the embryonic stem cell-derived dopaminergic neurons exhibited the functional characteristics of native dopaminergic neurons, including dopamine production as well as long distance extension and connection with target regions in the brain. (medgadget.com)
  • Subsequent transplantation of the cells into lethally irradiated mice results in engraftment of the animals with donor haematopoietic tissue containing the bacterial gene. (nature.com)
  • WO 2001/046401 discloses embryonic or stem-like cells produced by cross species nuclear transplantation. (justia.com)
  • Hematopoietic stem cells (HSCs) enable hematopoietic stem cell transplantation (HCT) through their ability to replenish the entire blood system. (lu.se)
  • We isolated bone marrow from mice at 8 time points after transplantation and examined the reconstitution dynamics and transcriptional profiles of stem and progenitor populations. (lu.se)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • Some in vivo transplantation studies have reported robust (35-50%) levels of transdifferentiation, which makes it unlikely that the results are due to cell fusion events. (i-sis.org.uk)
  • Following cell transplantation into a favorable environment, the transplanted NS/PCs survived well, facilitating remyelination and neuronal regeneration in host tissues. (biomedcentral.com)
  • We demonstrate that the combined therapeutic approach of HGF preconditioning and hiPSC-NS/PC transplantation enhances locomotor functional recovery post-SCI, highlighting a highly promising therapeutic strategy for acute to subacute SCI. (biomedcentral.com)
  • Hematopoietic stem cell transplantation (HSCT) results in the alteration of several components of the immune system. (medscape.com)
  • Transplantation can result in granulocytopenia as well as impairment of barrier defenses, cell-mediated immunity, and humoral immunity. (medscape.com)
  • Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)
  • Background: Allogeneic hematopoietic stem cell transplantation (alloHCT) is potentially curative but with known negative effects on quality of life. (cdc.gov)
  • Studies indicate that early unrelated hematopoietic stem cell transplantation in both the infantile and late-onset forms is associated with at least short-term benefits on neurocognitive parameters, lifespan, and quality of life. (medscape.com)
  • Hematopoietic stem cell (HSC) transplantation has also been used. (msdmanuals.com)
Biology8
  • MSCs played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material science. (techscience.com)
  • An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)
  • We have developed and renovated a 1400 sq. ft. shared-use stem cell laboratory called the Laboratory for Stem Cell Biology and Engineering. (ca.gov)
  • Past and current users of the Laboratory for Stem Cell Biology and Engineering include 52 researchers from 18 research groups, representing collaborations with 12 companies and 17 different universities and research institutes. (ca.gov)
  • Past and current users of the Laboratory for Stem Cell Biology and Engineering include 58 researchers (6 new researchers in the past year) from 18 research groups, representing collaborations with 12 companies and 17 different universities and research institutes. (ca.gov)
  • Thus, identifying the p63-driven regulatory networks, particularly in the global and genomic context, is a key step towards a better understanding of the biology of SG stem/progenitor cells and ultimately in directing new strategies in treating SG dysfunction. (grantome.com)
  • Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
  • However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)
Tissue22
  • The ESC-EC produced less NO on a per cell basis, but the same amount of NO if quantified based on the area of endothelial tissue. (ca.gov)
  • Background: Connective tissue progenitors (CTPs) from native bone marrow (BM) or their culture-expanded progeny, often referred to as mesenchymal stem/stromal cells, represents a promising strategy for treatment of cartilage injuries. (whiterose.ac.uk)
  • An infectious retrovirus vector has been used to transfer a bacterial gene encoding resistance to the neomycin analogue G418 into pluripotent haematopoietic stem cells present in explanted murine bone marrow tissue. (nature.com)
  • Although mesenchymal stem cells (MSCs) have been shown as a novel approach in tissue regeneration, the therapeutic potential of MSCs mediated by the interaction between MSC-derived paracrine mediators and Mφs remains elusive. (frontiersin.org)
  • 8 Jun, 2007 04:13 pm Stem cells provide the starting material for the development and repair of every organ and tissue in the body and they are present in all stages of life. (scitizen.com)
  • With the right mix of nutrients and a little bit of coaxing, human stem cells derived from skin can assemble spontaneously into brain-like chunks of tissue. (cbc-network.org)
  • The researchers found that tissue chunks cultured from stem cells derived from the skin of a single human with microcephaly did not grow as big as clumps grown from stem cells derived from a healthy person. (cbc-network.org)
  • They traced this effect to the premature differentiation of neural stem cells inside the microcephalic tissue chunks, depleting the population of progenitor cells that fuels normal brain growth. (cbc-network.org)
  • The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. (wikipedia.org)
  • Hematopoietic stem cells constitute 1:10,000 of cells in myeloid tissue. (wikipedia.org)
  • Enhanced expression of IL-6, IGF-1, TGF-β, and VEGF has also been observed in LC treated BMSCc+ groups, suggested the cardiac differentiation of BMSCc+, and can be utilized in tissue engineering for cardiac cell therapy. (techscience.com)
  • The Mesenchymal and Tissue Stem Cell Committee, which belongs to the International Society for Cellular Therapy, stated that plastic-adherent properties are the minimum criteria for determining MSCs. (techscience.com)
  • However, it can be challenging to differentiate when they are connected with wounded tissue, opposed to when they instruct tissue-specific progenitor cells responsible for the redevelopment of damaged tissue. (techscience.com)
  • The team first made mouse PGCs, and then added cells taken from the testicular tissue of newborn mice, as well as other biological molecules. (scientificamerican.com)
  • A CEA-Jacob team has just published a paper in which it demonstrates the central role of the transcription factor KLF4 in regulating the proliferation of epidermal stem cells and their ability to regenerate this tissue. (cea.fr)
  • Human skin completely renews itself every month thanks to the presence of stem cells in the deepest layer, which generate all the upper layers of this tissue. (cea.fr)
  • The discoveries of a French research team from the CEA, INSERM and the University of Paris, produced in collaboration with I-Stem, the AFM-Téléthon laboratory, and the University of Évry, opens perspectives for regenerative cutaneous medicine, in particular for the bio-engineering of skin grafts for tissue reconstruction. (cea.fr)
  • For this purpose, we use human stem cells that play a pivotal role in tissue development, maintenance and function. (gsi.de)
  • Two reports appeared as advance online publications in the top British journal Nature , accompanied by a news report that begins, "The hyped ability of adult stem cells to sprout replacement tissue types is being called into question. (i-sis.org.uk)
  • The acute-phase HGF-treated group exhibited vascularization, diverse anti-inflammatory effects, and activation of endogenous neural stem cells after SCI, which collectively contributed to tissue preservation. (biomedcentral.com)
  • Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)
  • Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)
Derived from embryonic stem3
  • Endothelial cells (EC) derived from embryonic stem cells (ESC) require additional functional characterization before they are used as a cell therapy. (ca.gov)
  • Endothelial cells (EC) derived from embryonic stem cells (ESC) require additional functional characterization before they are used as a cell therapy in order to enhance their potential for engraftment and proliferation. (ca.gov)
  • The study has shown that manipulation of KLF4 expression is also suitable for these cells, as reducing its expression in keratinocytes derived from embryonic stem cells (ESC) improves their proliferation capacity and their ability to reconstruct skin. (cea.fr)
Therapy15
  • The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
  • Gene therapy has been utilized successfully to repair or inactivate mutations in animal models of monogenic human diseases 19 as well as human in vitro cells 12 . (nature.com)
  • However, despite having the promising outcome of preclinical studies, the clinical application of stem cell therapy remained elusive due to little or no progress in clinical trials. (hindawi.com)
  • The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
  • Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)
  • The recent decade has seen encouraging outcomes of mesenchymal stem cell therapy that holds promise to alleviate the burden of neurological disorders Moreover, initial study data of preclinical trials have also indicated the effectiveness, tolerance, and safety of MSC-based therapy [ 10 ]. (hindawi.com)
  • However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)
  • Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
  • We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)
  • This work has been extended to other types of cells of interest for cutaneous cell therapy. (cea.fr)
  • 2. University of Évry, University of Paris-Saclay, INSERM U861, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-Stem), 91100 Corbeil Essonne, France. (cea.fr)
  • 3. Centre for the Study of Stem Cells (CECS), Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I Stem), 91100 Corbeil Essonne, France. (cea.fr)
  • Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
  • An experimental stem cell therapy for the treatment of mild to moderate amyotrophic lateral sclerosis (ALS) received a resounding rejection today from a US Food and Drug Administration (FDA) advisory panel that cited efficacy, safety, and product manufacturing concerns. (medscape.com)
  • These results provide novel insights into the role of IL1RAP in CML and a strong rationale for the development of an IL1RAP antibody therapy to target residual CML stem cells. (lu.se)
Stromal cells4
  • Clinical Relevance: The harvest technique of BM may be of major importance in determining the clinical success of BM mesenchymal stem/stromal cells in cartilage repair. (whiterose.ac.uk)
  • In the 1980's, Arnold Caplan and his colleagues published an isolation method of fibroblast-like stromal cells from bone marrow and first identified them as mesenchymal stem cells (MSCs) because of their multilineage differentiation potential ( Caplan, 1991 ). (frontiersin.org)
  • Mesenchymal stem cells (MSCs) are multipotent stromal cells capable of self-renewal and exhibit multilineage differentiation properties. (techscience.com)
  • At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)
Endothelial cells3
  • Functional characterization of embryonic stem cell-derived endothelial cells. (ca.gov)
  • 30 nm in diameter, establish direct membrane-to-membrane contact with endothelial cells in specialized areas of irregular endothelial basement membrane and enriched with vesicular activity. (elifesciences.org)
  • The cells could be made to differentiate into bone forming cells, cartilage forming cells, fat cells, skeletal muscle cells and endothelial cells. (i-sis.org.uk)
Therapies8
  • The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
  • These are considered stem cell-based therapies 3 and are used in the specialty of regenerative medicine. (mindbodygreen.com)
  • Vets around the world are already using stem cell therapies to treat horses for other types of conditions. (sciencedaily.com)
  • Researchers who are the first to create working nerve cells from horse stem cells say the advance may pave the way for cell therapies that target conditions similar to motor neuron disease. (sciencedaily.com)
  • Our research is an important step towards realising that potential for horses and provides an opportunity to validate stem-cell based therapies before clinical studies in humans. (sciencedaily.com)
  • Recently, a growing number of studies are focusing on mesenchymal stem cell-based therapies for neurodegenerative disorders. (hindawi.com)
  • hES cells also serve as a basis for cerebral organoid models (Figure C) to better understand e.g. the mechanisms of cognitive impairment and radiation necrosis as severe side effects of radiation therapies. (gsi.de)
  • Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
MSCs3
  • Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
  • MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
  • Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
Vitro7
  • erythroid cells after in vitro differentiation, despite having similar frequencies of phenotypic HSC initially. (lu.se)
  • Surfactant is produced by alveolar type II cells which can be differentiated in vitro from patient specific induced pluripotent stem cell (iPSC)-derived lung organoids. (nature.com)
  • 02:47 and red blood cells in vitro. (yale.edu)
  • generated haploid male gametes from mouse embryonic stem cells that can produce viable and fertile offspring, demonstrating functional reproduction of meiosis in vitro. (scientificamerican.com)
  • Our results suggest that ES cells recapitulate closely the early steps of muscle development in vivo and may serve as an excellent in vitro system to study this process. (uni-luebeck.de)
  • Dr. Jeffrey Millman was co-first author with colleagues at Harvard University in a report published in Cell entitled "Generation of Functional Human Pancreatic β Cells In Vitro" demonstrating a strategy for producing functional stem cell-derived β cells from human embryonic stem cells and induced pluripotent stem (iPS) cells. (wustl.edu)
  • Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
Regeneration9
  • But the cartilage regeneration capacity of these cells remains unpredictable because of cell heterogeneity. (whiterose.ac.uk)
  • Since the iliac crest remains a frequent site of BM harvest for musculoskeletal regeneration, the authors also compared the spatial distribution of these subsets in trabeculae of femoral head and iliac crest and found CD2711CD561 bone-lining cells in both tissues. (whiterose.ac.uk)
  • The principal investigator on this seminal fasting/stem cell study in mice, Ömer H. Yilmaz, M.D., Ph.D., shared the possible future implications on his research, that "fasting has many effects in the intestine, which included boosting regeneration as well as potential uses in any type of ailment that impinges on the intestine, such as infections or cancers. (mindbodygreen.com)
  • Although mice may show changes in stem cell function after just 24 hours, in humans, studies indicate prolonged fasts (several days) may be used to trigger stem-cell-based regeneration that rejuvenates the immune system. (mindbodygreen.com)
  • Taken together, our study provides a detailed functional and molecular characterization of HSCs at different phases of regeneration and identifies a gene set associated with the transition from proliferation to quiescence. (lu.se)
  • The intricate and dynamic balance between self-renewal, proliferation and differentiation of stem/progenitor cells of the salivary gland (SG) must be tightly regulated to ensure proper morphogenesis, homeostasis and regeneration. (grantome.com)
  • Second, we will use p63 knockout mouse models and lineage tracing experiments to determine the contribution of p63+ stem and progenitor cells during SG regeneration and in response to irradiation induced damage. (grantome.com)
  • Furthermore, we will define p63 dependent SG cellular identities and the defined cellular and molecular signature that is associated with regeneration and in response to irradiation by performing single cell RNA-sequencing (Aim2). (grantome.com)
  • Importantly, our genetic and genomic studies will also uncover novel ?Np63-pathways dependent and independent biomarkers and drivers of the distinct cell states associated with regeneration and radiosensitivity. (grantome.com)
Abstract2
  • abstract = "The mouse blastocyst-derived embryonic stem cell (ES cell) line BLC6 efficiently differentiates into myosin heavy chain-, desmin- and myogenin- positive skeletal muscle cells when cultivated in embryo-like aggregates (embryoid bodies). (uni-luebeck.de)
  • Neither the title of the paper, nor the abstract mentioned that in the experiment, five out of 25 rats receiving the transplant died with "teratoma-like tumors" in their brains, a well-known hazard of ES cells. (i-sis.org.uk)
Therapeutic6
  • Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
  • Dr Xavier Donadeu from the Roslin Institute, an author of the study, said: "Stem cells hold huge therapeutic potential both for people and animals. (sciencedaily.com)
  • Ischemic stroke is attributed to a high disability rate with limited or no therapeutic options for functional recovery [ 1 - 3 ]. (hindawi.com)
  • Britain s House of Lords final approval of therapeutic human cloning and embryonic stem cells research has intensified the battle for ascendancy between adult and embryonic stem cells. (i-sis.org.uk)
  • In vivo administration of IL1RAP antibodies in mice transplanted with chronic and blast phase CML cells resulted in therapeutic effects mediated by murine effector cells. (lu.se)
  • The therapeutic quality of dental pulp stem cells is largely based on their ability to retain their stemness characteristics. (bvsalud.org)
Adult19
  • Adult Stem Cells: The New Plastic Surgery? (scitizen.com)
  • 27 Jun, 2008 05:23 pm A new article in Live Science predicts that adult stem cells may replace silicone breast implants and other contemporary plastic surgery techniques. (scitizen.com)
  • Other techniques can reprogram "adult" cells in the human body taken from skin, for example -- but the cells still carry baggage from their previous state. (sciencedaily.com)
  • Indeed, if every disease known to man were cured by IPSCs or adult stem cells, the scientists would shrug and keep on cloning. (cbc-network.org)
  • Dr. Shinya Yamanaka of Japan and others have turned adult skin cells into human embryonic stem cells, without using an embryo. (nationalrighttolifenews.org)
  • The efficacy of these treatments has not been completely proven and they use adult stem cells, which are harder to maintain and are more restricted in the types of cells that they can become. (sciencedaily.com)
  • Neural stem cells (NSCs) serve as a source for new neurons in both the developing and adult brain. (elifesciences.org)
  • It is performed using a skin sample from the patient that contains adult keratinocytes and a minority population of keratinocyte stem cells. (cea.fr)
  • One of the difficulties encountered in this area is that fact that the keratinocytes obtained do not have all the functions of adult stem cells. (cea.fr)
  • In the latest skirmish, two rapid online publications are presented as if they were evidence against the existence of adult stem cells. (i-sis.org.uk)
  • This leaves one with the distinct impression that adult stem cells might not exist, and furthermore, they may be a health hazard. (i-sis.org.uk)
  • Fusion could also be obtained between ES cells and cells isolated from adult brain. (i-sis.org.uk)
  • These researchers pointed out that the spontaneous fusion rate (without interleukin-3) was extremely low, between 2-11 per million bone marrow cells, and is unlikely to account for all the findings with adult stem cells. (i-sis.org.uk)
  • In fact, the senior authors in both reports admit that some adult stem cells may genuinely revert to an earlier stage of development or switch fates [1]. (i-sis.org.uk)
  • Neither report cited a paper published last year in the journal Blood [4], where a group from the Stem Cell Institute, Department of Medicine, and Cancer Center, University of Minnesota Medical School, Minneapolis, reported the most comprehensive experiments proving that a single adult stem cell can differentiate into all cell types in culture. (i-sis.org.uk)
  • The finding that adult cells can fuse with ES cells is therefore irrelevant to the debate, and the fact that it was used in an attempt to discredit adult stem cells is itself revealing, particularly in view of other recent findings on ES cells. (i-sis.org.uk)
  • This latest anti-publicity on adult stem cells comes on the heels of a paper announcing success in embryonic stem (ES) cell transplant in a Parkinson rat model published in the house journal of the United States National Academy of Sciences [5]. (i-sis.org.uk)
  • They found that the spontaneous mutation frequency in ES cells is 100-fold lower than that in mouse embryonic fibroblasts (a somatic cell line), which is similar to adult cells in vivo . (i-sis.org.uk)
  • Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)
IPSC2
  • Using iPSC stem cells (ones acquires from skin cells), the scientists were able to create what they call mini livers that were then transplanted into rats. (slashgear.com)
  • Chad and I have both been principal investigators on the induced pluripotent stem cell (IPSC) grant. (medscape.com)
Differentiate2
  • Human embryonic stem cells (hESCs) derived from an early embryo can self-renew indefinitely and differentiate into a variety of cell types. (ashpublications.org)
  • Dental pulp stem cells have been isolated from deciduous and permanent teeth and have the potential to self-renew and differentiate. (bvsalud.org)
Proliferation10
  • Additional processes in which mitochondria are involved include heat production, storage of calcium ions, calcium signaling, programmed cell death (apoptosis) and cellular proliferation. (justia.com)
  • decreased cell proliferation, cell cycle arrest, and induction of apoptosis. (123dok.net)
  • It was suggested that HOXD9 contributes to both cell proliferation and/or cell survival. (123dok.net)
  • HOXD9 siRNA treatment of SK-MG-1 SP cells resulted in reduced cell proliferation. (123dok.net)
  • Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
  • PKC is an important signaling molecule in numerous cell pathways, including cell differentiation, proliferation and apoptosis. (medscape.com)
  • Most are involved in regulating processes such as the growth and division (proliferation), maturation (differentiation), or survival of cells. (medlineplus.gov)
  • For example, the protein produced from the FLT3 gene stimulates the proliferation and survival of cells. (medlineplus.gov)
  • Although the proteins produced from two other genes involved in CN-AML, IDH1 and IDH2 , are not normally involved in proliferation, differentiation, or survival of cells, mutations in these genes lead to the production of proteins with a new function. (medlineplus.gov)
  • Here, we show that primitive (CD34(+)CD38(-)) CML cells, in contrast to corresponding normal cells, express a functional interleukin-1 (IL-1) receptor complex and respond with NF-κB activation and marked proliferation in response to IL-1. (lu.se)
20232
  • May 25, 2023 The many types of cells in the human body are produced through the process of differentiation, in which stem cells are converted to more specialized types. (sciencedaily.com)
  • Cell Reports, Available online 14 November 2023. (lu.se)
Tissues7
  • 27 Jun, 2007 06:08 pm Stem cells have the potential to become all the cells and tissues in the human body. (scitizen.com)
  • But, he adds, the study also demonstrates the potential for using human-stem-cell-derived tissues to model other disorders, if cell growth can be controlled more reliably. (cbc-network.org)
  • Results: In this study, we found high expression of the HOXD9 gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. (123dok.net)
  • Moreover, the field is only inching forward scientifically as it is proving very hard to harness cells meant to create differentiated tissues in gestating embryos and fetuses. (nationalrighttolifenews.org)
  • Particularly, human embryonic stem cells (hES cells), which can give rise to all tissues of an organism (Figure A), are used to generate mature cells of the heart (Figure B) allowing us to study radiation/microgravity-induced cardiovascular alterations, which may occur during long-term space missions. (gsi.de)
  • They may instead be fusing with existing cells, creating genetically mixed-up tissues with unknown health effects" [1]. (i-sis.org.uk)
  • Because reticuloendothelial cells (eg, in the spleen) are rich in lysosomes, reticuloendothelial tissues are involved in a number of lysosomal storage disorders, but, generally, tissues richest in the substrate are most affected. (msdmanuals.com)
Neural4
  • Now, in what appears to be a very notable breakthrough, they have been used to make patient-specific, tailor made neural cells for study. (cbc-network.org)
  • Finally, we cultured human glioma cancer stem cells (GCSCs) from patient specimens found with high expression of HOXD9 in GCSCs compared with normal astrocyte cells and neural stem/progenitor cells (NSPCs). (123dok.net)
  • In glioma CSC (GCSC), the expression of some neural stem markers, such as SOX2 and Musa-shi-1, has been reported[6,7]. (123dok.net)
  • Blood vessels (BVs) are considered an integral component of neural stem cells (NSCs) niches. (elifesciences.org)
Regenerative5
  • They found that fasting caused fatty acid oxidation in these intestinal stem cells, and the regenerative capacity of these cells doubled compared to mice that did not fast. (mindbodygreen.com)
  • Using fasting (something our ancestors regularly practiced, due to food scarcity) to theoretically kill older and damaged intestinal cells or immune cells and replacing them with stem-cell-derived new ones opens doors to regenerative biohacking. (mindbodygreen.com)
  • Research carried out in the facility has made significant, high impact contributions in three areas of stem cell research: Molecular Mechanisms/Basic Science, Translational Bioengineering, and Regenerative Medicine. (ca.gov)
  • This expansion phase involves a risk: it may be accompanied by a quantitative loss or degradation of stem cells, leading to a loss of regenerative potential. (cea.fr)
  • Np63, a stem cell enriched transcription factor, plays a critical role in epithelial regenerative function as evident from the phenotype of ?Np63-null animals which exhibit developmental arrest and agenesis of epithelial-rich organs including the SG. (grantome.com)
Lineages2
  • Hematopoietic stem cells (HSC) give rise to all types of blood lineages, including red blood cells (RBC). (lu.se)
  • Myeloid and lymphoid lineages both are involved in dendritic cell formation. (wikipedia.org)
20211
  • 15, 2021 Using a new single-cell technique, researchers have uncovered a way to understand the programming behind how stem cells make particular cell types. (sciencedaily.com)
Mechanisms1
  • however, the mechanisms governing telomere length homeostasis in these cell types are unclear. (sens.org)
Heterogeneity3
  • Hypothesis: The harvest technique of BM may highly influence stem cell heterogeneity and, thus, cartilage formation because these cells have distinct spatial localization within BM from the same bone. (whiterose.ac.uk)
  • Consequently, investigation of molecular heterogeneity in the differentiation potential of HSPC is vital to identify novel regulators that affect generation of specific cell types, especially RBC. (lu.se)
  • One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)
Gene5
  • The HOXD9 gene was highly expressed in a side population (SP) of SK-MG-1 cells that was previously identified as an enriched-cell fraction of glioma cancer stem-like cells. (123dok.net)
  • The results of the paper published in Nature Biomedical Engineering show that reducing the expression of the KLF4 gene during graft preparation promotes rapid expansion of functional stem cells1, without damaging their genomic stability. (cea.fr)
  • immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
  • The proteins produced from the CEBPA and DNMT3A genes regulate gene activity and help to control when cells divide and how they mature. (medlineplus.gov)
  • The NPM1 gene provides instructions for a protein that is likely involved in the regulation of cell growth and division. (medlineplus.gov)
Genes8
  • Deep sequencing followed by abundancy ranking pinpointed six top hit genes potentially associated with either improved or impaired endodermal differentiation, which were selected for functional validation in CRISPR-Cas9 mediated knockout (KO) lines. (mdpi.com)
  • We've demonstrated that we don't have to manipulate the pluripotent genes to get to the ground state, but rather that we can block all other options of where the cell 'wants' to go. (sciencedaily.com)
  • Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
  • But, although the mutation frequency of genes was much lower in ES cells, mutant ES cells accumulated with time in culture. (i-sis.org.uk)
  • Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
  • To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
  • The proteins produced from these genes have different functions in the cell. (medlineplus.gov)
  • To demonstrate the levels of parathyroid hormone secretion and genetic expressions of parathyroid hormone (PTH) and PTH1 receptor (PTH1R) genes in the dental pulp stem cells (DPSCs) from different age groups before and after induction of osteogenic differentiation. (bvsalud.org)
Differentiation of stem1
  • Advances in bioengineering have addressed problems of how to control growth and differentiation of stem cells using novel biomaterials, how to sort and purify specific stem cell products, and how to deliver and sustain stem cell grafts in vivo. (ca.gov)
20161
  • WO 2016/135723 to the present inventors discloses mammalian bone marrow cells enriched with mitochondria for treatment of mitochondrial diseases. (justia.com)
CD344
  • citation needed] Hematopoietic stem cells can be identified or isolated by the use of flow cytometry where the combination of several different cell surface markers (particularly CD34) are used to separate the rare Hematopoietic stem cells from the surrounding blood cells. (wikipedia.org)
  • A higher proportion of CD34 + cells (∼ 20%) could be derived from hPSCs by inhibition of mitogen-activated protein kinase (MAPK) extracellular signal-regulated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling and activation of bone morphogenic protein-4 (BMP4) signaling. (ashpublications.org)
  • hPSC-derived CD34 + progenitor cells further developed to endothelial and smooth muscle cells with functionality. (ashpublications.org)
  • Our results suggest that combined modulation of signaling pathways may be an efficient means of differentiating hPSCs into functional CD34 + progenitor cells. (ashpublications.org)
Molecular3
  • Moreover, we observed molecular changes in cell cycle, MYC and mTOR signaling in both HSCs, and progenitor subsets. (lu.se)
  • KLF4 is therefore a new molecular target for preserving the functionality of stem cells and making progress in the bio-engineering of skin grafts. (cea.fr)
  • Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)
HSCs6
  • Second, compared to BM, extramedullary hematopoietic stem cells/multipotent progenitors (HSCs/MPPs) from the spleen, PB, and mobilized PB to have a shared transcriptional profile and a higher abundance of lineage-primed subsets. (physiciansweekly.com)
  • Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. (wikipedia.org)
  • Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal's lifespan. (biorxiv.org)
  • Here, we show that young and aged LT-HSCs respond differently to inflammatory stress, such that aged LT-HSCs produce a cell-intrinsic, myeloid-biased expression program. (biorxiv.org)
  • Using single-cell RNA-seq, we identify a myeloid-biased subset within the LT-HSC population (mLT-HSCs) that is much more common amongst aged LT-HSCs and is uniquely primed to respond to acute inflammatory challenge. (biorxiv.org)
  • Aged LT-HSCs demonstrate a cell-intrinsic myeloid bias during inflammatory challenge. (biorxiv.org)
Lymphocytes3
  • In shape, hematopoietic stem cells resemble lymphocytes. (wikipedia.org)
  • Finally, using primary lung stem cells or lymphocytes from different donors, we study the effects of radon on patients, who are treated in radon spas or baths to alleviate rheumatic diseases. (gsi.de)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
Embryonic cell1
  • The method involves microinjecting heterologous mitochondria into an oocyte or embryonic cell wherein the heterologous mitochondria are capable of achieving at least normal levels of mitochondrial membrane potential in the oocyte or embryonic cell. (justia.com)
Progenitors1
Multipotent2
Pluripotency3
  • Writing in the journal Cell Stem Cell , the team reports that more than half of mouse epiblast stem cells treated with the drug reversed course within three days, and regained an embryonic "be anything" state, also called pluripotency. (sciencedaily.com)
  • Past attempts by other teams to restore pluripotency to mouse cells from the epiblast stem cell state have yielded far lower amounts, or non-viable cells. (sciencedaily.com)
  • Automatically expanded hiPSCs exhibit normal growth characteristics, and show sustained expression of the pluripotency associated stem cell marker TRA-1-60 over at least 5 weeks (10 passages). (frontiersin.org)
Neuronal2
  • In this webinar, Dr. P. Joel Ross (The Hospital for Sick Children, Toronto) describes how patient-specific iPS cell-derived neurons can be functionally characterized and used to identify neurodevelopmental disorder-associated neuronal phenotypes. (stemcell.com)
  • Intracerebral grafting of neuronal cell suspensions II. (lu.se)
Grafts3
Genomic1
  • We propose to use knockout and transgenic mouse models and genomic tools to better elucidate the functional role of p63 and to identify crucial signaling pathways in salivary gland organogenesis. (grantome.com)
Transplants1
  • The livers 'remained functional,' according to the study, for the four days they spent as transplants in the rats. (slashgear.com)
Donor3
  • Results: Cells from the BM after rasping were significantly more chondrogenic than the donor-matched aspirate, whereas no notable difference in their osteogenic or adipogenic potential was observed. (whiterose.ac.uk)
  • Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
  • The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. (medscape.com)
Mouse embryonic1
Research11
  • 8 Feb, 2008 06:09 pm Six years ago, biomedical engineer Michael King was exploring the strange rolling motion of white blood cells when his research took a radical turn. (scitizen.com)
  • 27 Nov, 2007 10:41 am Tony Maciulis talks with Dr. Jon LaPook about a breakthrough in stem cell research. (scitizen.com)
  • 21 Nov, 2007 10:54 am A huge advancement in stem cell research--and a stake in the heart of human cloning--was announced yesterday. (scitizen.com)
  • 6 Sep, 2007 12:57 pm British authorities decided yesterday to permit research that uses animal eggs to create human stem cells because of the limited supply of human eggs. (scitizen.com)
  • 25 Jun, 2007 04:43 pm On June 7, the House of Representatives voted 247-176 to pass a bill (S 5) that would allow federal funding for research using stem cells derived from. (scitizen.com)
  • In the 2018 study that garnered attention for the effect of fasting on stem cells 1 , the research team fasted mice acutely (for 24 hours) and then harvested stem cells from their intestines. (mindbodygreen.com)
  • The University of California at Santa Barbara (UCSB) is well positioned to make significant contributions by leveraging fundamental stem cell-based biomedical research efforts with enabling technologies in materials, microfluidics and bioengineering. (ca.gov)
  • The overall mission of this laboratory is to facilitate and promote stem cell research by investigators at UCSB, as well as those at neighboring universities, research institutes, and biotechnology companies on the California central coast. (ca.gov)
  • All research areas are substantiated by analyses (Figure D) monitoring the acute radiation-induced cytogenetic damage and the long-term genetic stability of cells. (gsi.de)
  • At International Society for Stem Cell Research-the big stem cell meeting-Yamanaka revealed one more factor. (medscape.com)
  • Johan Jakobsson, a professor at Lund University and research group leader at Lund Stem Cell Center, explains, "LINE-1 retrotransposons are a rich source of genetic sequences that we suspect have shaped the evolution of the human brain, and we now have the tools to explore their role in brain development. (lu.se)
Scientists11
  • Scientists have found a way to possibly avoid using embryonic stem. (scitizen.com)
  • In a surprising new finding, scientists have shown that mouse stem cells treated with the drug reverted to an 'embryonic' state. (sciencedaily.com)
  • It's the first time that scientists have shown they can get stem cells to revert to their original state by erasing specific labels called epigenetic markers. (sciencedaily.com)
  • The induced pluripotent stem cell breakthrough continues to be useful in the very ways that "the scientists" once said only human cloning could provide. (cbc-network.org)
  • Example: In Japan, scientists have discovered the chemical that induces bone marrow to produce healing cells. (nationalrighttolifenews.org)
  • The chemical which summons stem cells from bone marrow to the site of a wound has been discovered by scientists in the UK and Japan. (nationalrighttolifenews.org)
  • Scientists at Osaka University and King's College London gave mice bone marrow cells that glow green - which can be tracked while moving round the body. (nationalrighttolifenews.org)
  • Horses suffering from neurological conditions similar to those that affect humans could be helped by a breakthrough from stem cell scientists. (sciencedaily.com)
  • Horse stem cells have been produced in the laboratory before but this is the first time that scientists have created working cells of a specific type from them. (sciencedaily.com)
  • But some scientists are not convinced by the report, which is published today in Cell Stem Cell . (scientificamerican.com)
  • Other scientists raise specific concerns that mainly relate to the timing of the processes that lead to the sperm cells. (scientificamerican.com)
Replenish1
  • Because of this, these types of cells can serve as a repair system and theoretically divide without limit to replenish other cells for as long as you are alive. (mindbodygreen.com)
Epithelial4
  • Here we show the differentiation of patient specific iPSCs derived from a patient with SFTPB deficiency into lung organoids with mesenchymal and epithelial cell populations from both the proximal and distal portions of the human lung. (nature.com)
  • Alveolar type II (ATII) epithelial cells synthesize, secrete and recycle all components of surfactant and dysfunction in surfactant metabolism can result in a variety of pediatric lung diseases including respiratory distress syndrome and interstitial lung disease 3 . (nature.com)
  • Although many differentiation protocols in the literature have been successful in mimicking lung development from stem cells, there has not been an examination of how a specific mutation impacts the differentiation process including its effects on the early endoderm, as well as the proximal and distal lung epithelial cell populations in the lung organoids. (nature.com)
  • During animal development, epithelial stem and progenitor cells of the salivary gland undergo a number of dynamic processes of maturation and differentiation, all of which require the coordinated action of functionally important transcription factors such as p63. (grantome.com)
Mice2
  • The results of an important 2018 study 1 in the journal Cell Stem Cell showing that fasting for 24 hours augmented stem cell function in mice blasted the headlines of every major news outlet. (mindbodygreen.com)
  • Another CFU, the colony-forming unit-spleen (CFU-S), was the basis of an in vivo clonal colony formation, which depends on the ability of infused bone marrow cells to give rise to clones of maturing hematopoietic cells in the spleens of irradiated mice after 8 to 12 days. (wikipedia.org)
Dopamine neurons1
  • Stem Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease? (lu.se)
Breakthrough1
Markers4
  • We further characterized the subphenotype of our ESC-EC and observed both venous and arterial markers on individual cells with a larger percentage of the cells exhibiting a venous phenotype. (ca.gov)
  • Lack of expression of lineage markers is used in combination with detection of several positive cell-surface markers to isolate hematopoietic stem cells. (wikipedia.org)
  • old DPSCs (oDPSCs), 60+ years old) were characterized for mesenchymal stem cell (MSC) markers. (bvsalud.org)
  • All SHEDs, yDPSCs, and oDPSCs were found to be expressing mesenchymal stem cell markers. (bvsalud.org)
Innate1
  • Lymphoid cells include T cells, B cells, natural killer cells, and innate lymphoid cells. (wikipedia.org)
Lund University1
Peripheral blood1