• Macroscopically, there were nodular lesions with crust formation, and histologically, the lesions were characterized by hyperplasia of the spinous layer associated with multiple eosinophilic intracytoplasmic inclusions. (pvb.org.br)
  • After the primary infection, the virus spreads from the infected epithelial cells to nearby sensory nerve endings and is transported along the nerve axon to the cell body located in the trigeminal ganglion. (medscape.com)
  • Epithelial scrapings with Giemsa stain may show multinucleated giant cells, resulting from coalescence of infected corneal epithelial cells and intranuclear viral inclusions. (medscape.com)
  • Multiple large areas of ulceration covered by a serocellular crust are apparent on the conjunctival surface of the eyelid and moderate neutrophilic and lymphocytic infiltration is apparent in the underlying mucosa. Epithelial cells immediately adjacent to the ulcerated areas are enlarged and occasionally contain large eosinophilic to amphophilic intra-nuclear inclusion bodies with marginated chromatin. There are accompanying necrotic -�-�ghost epithelial cells. (askjpc.org)
  • Oval fat bodies - These are degenerating renal tubular epithelial cells or macrophages containing abundant lipid. (pathologicalbodies.com)
  • [ 2 ] The arachnoid cells have several proposed functions, including acting as a structural barrier with cellular wrapping/ensheathing, acting as a conduit for cerebrospinal fluid (CSF) drainage/absorption into dural sinuses/veins (arachnoid villi), epithelial-like/secretory functions, monocytelike functions, trophic support and byproduct detoxification for glial and neuronal cells, and participation in reactive/reparative processes. (medscape.com)
  • Both non-neoplastic meningothelial cells and meningiomas possess mixed features of epithelial and mesenchymal cells. (medscape.com)
  • The classification of epithelial tumors of the kidney has in particular undergone substantial progress in the last two decades with major contributions from genetic typing of renal cell carcinomas (RCCs). (abdominalkey.com)
  • In breast tissue, the luminal epithelial cells express CK 8/18, CK 7 and CK 19, while basal/myoepithelial cells express CK 5/6, CK 14 and CK 17. (ijpmonline.org)
  • CMV infection characteristically is associated with "owl's-eye" cells, which are large cells with basophilic intranuclear inclusions and a surrounding clear zone. (medscape.com)
  • However, sebaceous carcinoma was excluded due to the absence of cells with bubbly cytoplasm along with the absence of admixed basaloid cells (option C). Clear cell hidradenoma is a rare tumor usually seen in the females and mostly shows the presence of dual population of clear cells and cells with moderate eosinophilic cytoplasm with no atypical mitosis (option D). (cytojournal.com)
  • Rhabdoid cells were also seen scattered among the tumor cells. (biomedcentral.com)
  • The large tumor cells had large atypical nuclei and a relatively high frequency of mitotic figures. (biomedcentral.com)
  • Of note, rhabdoid cells with cytoplasmic inclusion bodies were detected scattered among the tumor cells. (biomedcentral.com)
  • Astrocytes that are infected by the virus enlarge and take bizarre appearance (distortion of the nuclei with enlargement or multiple nuclei) and resemble the tumor cells in giant cell astrocytomas. (medscape.com)
  • Cytoplasmic inclusions usually are present in cells infected with RNA viruses. (medscape.com)
  • On light microscopic analysis, there is an endomysial accumulation of mononuclear cells, particularly CD8+ T cells (similar to the findings in PM). Other characteristic findings in muscle include vacuoles lined with basophilic granules, eosinophilic inclusions, abnormal microtubular filaments in nuclear and cytoplasmic inclusions, and ragged red fibers. (rheumaknowledgy.com)
  • Odland bodies - Small, granular, membrane-bound vacuoles found in the cytoplasm of skin keratinocytes. (pathologicalbodies.com)
  • Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. (ucdenver.edu)
  • The vacuoles are often associated with cytoplasmic and occasionally intranuclear eosinophilic inclusions. (nih.gov)
  • A skin biopsy revealed eosinophilic spherical inclusion bodies in the nuclei of small sweat gland cells, fibroblasts and fat cells, whilst immunohistochemistry revealed that p62 and ubiquitin antibodies were positive. (unboundmedicine.com)
  • Microscopic findings are multifocal necrosis with syncytia in multiple organs, commonly including liver, spleen, lymph nodes and other lymphoid tissue(5). Hallmark syncytia of MHV infection are characterized by large degenerating cells at the periphery of necrotic foci, containing dense basophilic nuclei and nuclear remnants. (askjpc.org)
  • d) smears showing cells forming acini with nuclei showing fine chromatin, small nucleoli, clear cytoplasm and occasional atypical mitotic figure (arrow) (May-Grunwald-Giemsa, ×40). (cytojournal.com)
  • The cells showed mild pleomorphism, abundant pale cytoplasm with vacuolation and nuclei having coarse chromatin, and a few with prominent nuclei. (cytojournal.com)
  • Parabasal bodies - Cytoplasmic bodies closely associated with the nuclei, kinetoplasts and basal bodies in certain parasitic flagellate protozoa. (pathologicalbodies.com)
  • In the largest follicle, there are several large, naked nuclei with marginated chromatin, that are distended with amphophilic material (equivocal intranuclear viral inclusion bodies). (animalhealthaustralia.com.au)
  • An abnormality in which the nuclei of sarcomeres take on an abnormally central localization (or in which this feature is found in an increased proportion of muscle cells). (nih.gov)
  • Overlap of nuclei - "cells do not respect each other's borders" (easy to see at key feature at low power ). (librepathology.org)
  • Nuclei not pseudostratified, if pseudostratified consider columnar cell variant . (librepathology.org)
  • Pseudostratification of the nuclei (like in colorectal adenocarcinoma), differentiates from tall cell variant . (librepathology.org)
  • Karyomegaly is characterized by acinar cells with enlarged, often pleomorphic nuclei (arrow) and frequent intranuclear pseudoinclusions (arrowhead). (nih.gov)
  • Karyomegaly is characterized by acinar cells with enlarged nuclei (arrow), which are often pleomorphic. (nih.gov)
  • Within the follicular epidermis (1-6 cells deep) surrounding the developing feather, there are scattered necrotic epidermal cells and, in the basal areas, small numbers of macrophages with numerous intracytoplasmic, basophilic, botryoid inclusion bodies. (animalhealthaustralia.com.au)
  • In contrast to PM/DM, distal muscle weakness, and asymmetric involvement are more commonly seen in inclusion body myositis. (rheumaknowledgy.com)
  • Often the diagnosis of inclusion body myositis is made when patients with presumed PM or DM either do not respond to steroid therapy or display atypical manifestations (e.g., asymmetry, distal muscle weakness, peripheral neuropathy). (rheumaknowledgy.com)
  • In alveolies accumulation of neutrophils can be identified, and enlarged, vacuolated macrophages with several multinucleated giant cells. (wikipedia.org)
  • In addition hypertrophy of type II pneumocytes, formation on abnormal cystic airspaces and viral eosinophilic intranuclear inclusion bodies in intraluminal macrophages. (wikipedia.org)
  • Multifocal ulcers covered by serocellular crust are present on the anterior surface of the eyelid. There is a moderate perifollicular and mural follicular inflammatory infiltrate consisting of macrophages, occasional neutrophils, lymphocytes and plasma cells along with a large numbers of mast cells. Hair follicles often contain mites. (askjpc.org)
  • There are large irregular necrotic areas (about 35% of the nodular mass) comprising a coagulum of degenerate eosinophils and cell debris, bordered in some areas by a palisade of macrophages, fibrosis and rare foci of lymphocytes. (animalhealthaustralia.com.au)
  • This disordered epidermis of the developing feather contains macrophages with prominent intracytoplasmic, basophilic, botryoid inclusion bodies (as in the surrounding follicular epidermis), and these cells extend, often in large numbers, into the pulp which also contains many prominent small vessels and small to moderate numbers of small macrophages, lymphocytes, and heterophils. (animalhealthaustralia.com.au)
  • There were no nuclear grooves or intranuclear inclusions characteristic of papillary carcinoma, no papillary or follicular structure, and no necrosis or calcification. (biomedcentral.com)
  • The nuclear membrane of the infected recipient cell serves as the source of the lipid component. (doctor-dr.com)
  • true nuclear inclusions in contrast are seen only in viral infections). (librepathology.org)
  • Nuclear inclusions are quite rare and not required to make the diagnosis -- but a very convincing feature if seen. (librepathology.org)
  • The cells are polygonal to oval with distinct cell borders, a moderate amount of faintly eosinophilic cytoplasm obscured by large numbers of blue-grey granules, and with a central nucleus, which is round to oval with coarsely stippled to vesicular chromatin and a single, often inconspicuous, nucleolus (well-differentiated mast cells). (animalhealthaustralia.com.au)
  • Papillary mesenchymal bodies - These are aggregations of fibroblasts that represent abortive attempts to form the papillary mesenchyme responsible for hair induction. (pathologicalbodies.com)
  • Although some of the observed variants, such as chondroid meningiomas, clear-cell meningiomas, papillary meningiomas, and rhabdoid meningiomas, are associated with unfavorable prognoses, the other histologic patterns are not indicators of unfavorable biologic behavior. (medscape.com)
  • The role of genotyping and ancillary tools, in particular immunohistochemistry, in correctly classifying these tumors is highlighted in the section on Renal Cell Carcinoma. (abdominalkey.com)
  • It is thought that leiomyoma is the result of either transformation of normal uterine muscle cells into abnormal cells through somatic mutations , or through the growth of abnormal uterine muscle cells into tumors. (wikidoc.org)
  • Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease, the clinical manifestations of which are complex and easily misdiagnosed. (unboundmedicine.com)
  • Owl's eye bodies - These are usually associated with the owl's eye inclusion bodies found in tissues infected with the cytomegalovirus infection, a disease which can cause multiple organ dysfunction. (pathologicalbodies.com)
  • A cytological diagnosis of clear cell adenocarcinoma was given with probable metastases from RCC. (cytojournal.com)
  • The absence of inflammatory cells clearly excluded the possibility of abscess (option A). The skin adnexal tumors with clear cells which constituted the differential diagnosis include sebaceous carcinoma and clear cell hidradenomas. (cytojournal.com)
  • Nonetheless, muscle biopsy with electron microscopic analysis is required to make a diagnosis of inclusion body myositis. (rheumaknowledgy.com)
  • The differential diagnosis of inclusion body myositis includes other types of IIM as well as other endocrinologic, metabolic, infectious, and toxic etiologies (see Myopathy ). (rheumaknowledgy.com)
  • Psammoma bodies are awesome if you see 'em, i.e. useful for arriving at the diagnosis. (librepathology.org)
  • Immunostaining was performed for various markers, and on the basis of these results, we diagnosed the lesion as primary mucinous carcinoma with rhabdoid cells in the thyroid gland. (biomedcentral.com)
  • Furthermore, primary mucinous carcinoma of the thyroid gland with rhabdoid cells has never been previously reported. (biomedcentral.com)
  • Here, we describe our experience with the first reported case of primary mucinous carcinoma of the thyroid gland with rhabdoid cells and discuss our findings in the context of the extant literature. (biomedcentral.com)
  • yearly ultra- sound signs, such as prostate cancer, small cell lung carcinoma cells, but has no meniscal attachment. (familytreecounseling.com)
  • Transmission electron microscopy revealed intranuclear herpetic inclusions, and immunostaining revealed HuAHV1 and herpesvirus particles in neurons, glial cells, tongue mucosal epithelium, and hepatocytes. (cdc.gov)
  • Fowl adenovirus serotype 4 (FAdV-4) and FAdV-8b are causative agents of hepatitis-hydropericardium syndrome (HHS) and inclusion body hepatitis (IBH), respectively. (biomedcentral.com)
  • The tumour cells of the nodule are arranged in sharply-circumscribed, confluent sheets and peripheral cords dissected by bundles of dermal collagen. (animalhealthaustralia.com.au)
  • The cat presented in poor body condition with pale mucus membranes. Focal areas of alopecia extended over both upper eyelids to the bases of both ears, and red crusted lesions were present over the upper eyelids and lateral canthuses (more extensive on the right). The right third eyelid was thickened and erythematous as were the nasal conchae. (askjpc.org)
  • Olivary bodies - Rounded elevations lateral to the upper part of each pyramid of the medulla oblongata. (pathologicalbodies.com)
  • Between the main cellular mass and the single lateral surgical margin, there is a 2mm wide zone of collagenous dermis and panniculus carnosus, and within 0.2mm of this surgical margin there are two discrete dermal nests of tumour cells. (animalhealthaustralia.com.au)
  • In this case, although the main nodular tumour mass appears to have been excised (the tumour nodule in the specimen appears to have been bisected by post-surgical tissue trimming), the presence of two small nests of mast cells close to the lateral surgical margin, suggests that excision may not be complete. (animalhealthaustralia.com.au)
  • Primary infection of any of the three (ie, ophthalmic, maxillary, mandibular) branches of cranial nerve V can lead to latent infection of nerve cells in the trigeminal ganglion. (medscape.com)
  • Therefore, absence of inclusions does not always exclude infection or active disease. (medscape.com)
  • After initial infection, all herpesviruses remain latent within specific host cells and may. (msdmanuals.com)
  • 1. Severe acute ulcerative conjunctivitis with intralesional intranuclear inclusion bodies consistent with feline herpesvirus infection. (askjpc.org)
  • A minor skin abrasion can allow the HSV virus to infiltrate the body and cause an infection after mouth-to-skin contact. (doctor-dr.com)
  • These bodies are generally associated with trichoepithelioma, one of the tumours of the follicular epithelium. (pathologicalbodies.com)
  • Pampiniform bodies - Rudimentary organs homologous with the male epididymis that lie in the broad ligament of the uterus next to the ovary and fallopian tube. (pathologicalbodies.com)
  • On microscopic histopathological analysis, elongated and spindle-shaped cells with a cigar-shaped nucleus are characteristic findings of leiomyoma. (wikidoc.org)
  • Meningiomas , as defined by the World Health Organization (WHO), are "meningothelial (arachnoid) cell neoplasms, typically attached to the inner surface of the dura mater," and these tumors fall into WHO grades I, II, and III. (medscape.com)
  • Cytological smears were cellular with cells arranged in sheets, acini, and few papillaroid structures in hemorrhagic background [ Figure 1a ]. (cytojournal.com)
  • Pathological examination revealed the presence of abundant mucus and agglomeration of large atypical cells. (biomedcentral.com)
  • Agglomerations of large atypical cells were also detected (Fig. 2b ). (biomedcentral.com)
  • Developmental lesions such as heterotopia of meningothelial cells in the scalp are believed to be the origin of meningiomas under the scalp and skin of the head. (medscape.com)
  • Immunohistochemical staining for cytokeratin 5/6 was applied on cell block sections of 23 cases of benign and 25 cases of malignant breast lesions using avidin biotin peroxidase technique. (ijpmonline.org)
  • If there are no papillae structures -- you're unlikely to see psammoma bodies. (librepathology.org)
  • The virus is thought to enter the body via the respiratory or oral route. (medscape.com)
  • The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. (ucdenver.edu)
  • A number of co-receptors, including HveA (Herpes virus entry mediator A, also known as HVEM, Herpes Virus Entry Mediators), must be activated by gD in order for HSV1 to enter cells. (doctor-dr.com)
  • Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease. (ucdenver.edu)
  • This is followed by the fusion of the viral envelope with the cell plasma membrane and the delivery of the viral capsid into the cell cytoplasm. (doctor-dr.com)
  • It undergoes DNA replication and synthesis of viral capsid proteins inside the cell. (medscape.com)
  • The presence of viral inclusions is diagnostic, although this method has low sensitivity. (medscape.com)
  • Diagnostic criteria for inclusion body myositis have been proposed but not validated (Table 19). (rheumaknowledgy.com)
  • Pacchionian bodies - Enlarged fleshy processes or villi on the outer surface of the dura mater of the brain, also called arachnoid villi or arachnoid granulations. (pathologicalbodies.com)
  • Meningiomas , as defined by the 2016 World Health Organization (WHO), are "a group of mostly benign, slow-growing neoplasms that most likely derive from the meningothelial cells of the arachnoid layer. (medscape.com)
  • These bodies are membrane-bound, contain granular, electron dense material and are thought to be closely related to rough endoplasmic reticulum. (pathologicalbodies.com)
  • In such instances, inclusion body myositis should be suspected, and muscle biopsy repeated or reviewed with emphasis on electron microscopic findings. (rheumaknowledgy.com)
  • Cell culture is the most popular method of virus propagation because of its high sensitivity. (ijpmonline.org)
  • Within the attenuated panniculus carnosus underlying the nodule there are small numbers of eosinophils, occasional individual mast cells and segmental contracture and disruption of the deepest skeletal muscle fibres (possibly sampling artifact), but no evidence of neoplastic mast cells in the underlying subcuticular fascia. (animalhealthaustralia.com.au)