Cells which inherit the plasmid arrest cells cell cycle. Medical search. Frequent questions

Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)
First, we found that GS-002 significantly inhibited cell proliferation and induced cell apoptosis in dose-dependent manners. (hindawi.com)
Furthermore, we found that GS-002 induced more cell apoptosis in ATF-3-overexpressing cells. (hindawi.com)
PGM1 knockdown stimulated both cell proliferation and colony formation, and inhibited cell cycle arrest and apoptosis, while overexpression of PGM1 produced the opposite effects in CRC cells both in vivo and in vitro. (biomedcentral.com)
The absence of NuRD triggers apoptosis via the EGL-1-CED-9-CED-4-CED-3 pathway, while an ectopic gain of NuRD enables apoptotic daughter cells to survive. (elifesciences.org)
Usually, this will make the cell initiate apoptosis leading to its own death, but sometimes mutations in the cell hamper this process and thus cause progression of cancer . (wikipedia.org)
In this review, we highlight recent evidence related to the molecular mechanism of lncRNAs in growth, survival, invasion, metastasis, angiogenesis and apoptosis of PC cells, and discuss the potential clinical application of lncRNAs to the diagnosis, treatment and prognostic prediction of PC. (oncotarget.com)
Cell apoptosis was analyzed by flow cytometry. (jcancer.org)
PYCR1 interference was able to inhibit cell proliferation and promote cell apoptosis of pancreatic cancer. (jcancer.org)
Cell proliferation and apoptosis were measured using CCK8, EdU staining, flow cytometry, and TUNEL assays. (biomedcentral.com)
Natural product anticancer agents enhance intracellular levels of ceramide, a sphingolipid that promotes cell apoptosis. (sphingolipidclub.com)

This study shows that, similarly to H3 , histone H4 is inherited asymmetrically in Drosophila melanogaster male germline stem cells undergoing asymmetric division. (sdbonline.org)

Chromosomal toxin-antitoxin systems also exist, some of which are thought to perform cell functions such as responding to stresses, causing cell cycle arrest and bringing about programmed cell death. (wikipedia.org)
It has been proposed that chromosomal homologues of plasmid toxin-antitoxin systems may serve as anti-addiction modules, which would allow progeny to lose a plasmid without suffering the effects of the toxin it encodes. (wikipedia.org)
For example, a chromosomal copy of the ccdA antitoxin encoded in the chromosome of Erwinia chrysanthemi is able to neutralize the ccdB toxin encoded on the F plasmid and thus, prevent toxin activation when such a plasmid is lost. (wikipedia.org)
If these structures are manipulated incorrectly, through processes known as chromosomal instability and translocation, the cell may undergo mitotic catastrophe . (wikipedia.org)
In addition, cells with homozygous truncations in BRCA2 are genetically unstable [ 8 , 9 , 11 ] and are lacking in homology-directed DNA repair of chromosomal breaks [ 12 , 13 ]. (ijbs.com)
Additionally, chromosomal rearrangements, increased rates of sister chromatid exchanges and double strand breaks have been observed in cells from heterozygous mutation carriers of BRCA2 [ 17 , 18 ]. (ijbs.com)

In stratified epithelia proliferative basal cells adherent to the underlying basement membrane undergo cell cycle arrest then outward migration and terminal differentiation. (stanford.edu)
Without dystrophin, muscles are susceptible to mechanical injury and undergo repeated cycles of necrosis and regeneration. (medscape.com)
Many stem cells undergo asymmetric division to produce a self-renewing stem cell and a differentiating daughter cell. (sdbonline.org)

For short hairpin RNA (shRNA) targeting of BRCA2, the pRETRO-SUPER plasmid [ 19 ] was utilized as previously described [ 20 ]. (ijbs.com)
Targeting of luciferase using the pRETRO-SUPER shRNA plasmid was also as described [ 20 ]. (ijbs.com)
We examined the consequences of CTCF depletion in immortalised human and mouse cells using shRNA knockdown and CRISPR/Cas9 genome editing and examined the growth and development of heterozygous Ctcf ( Ctcf +/- ) mice. (preprints.org)

Several main apoptotic indicators were found in GS-002-treated cells, such as the cleaved forms of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP). (hindawi.com)
Here, we demonstrate that the nucleosome remodeling and deacetylase (NuRD) complex is asymmetrically segregated into the surviving daughter cell rather than the apoptotic one during ACDs in Caenorhabditis elegans . (elifesciences.org)
It is noteworthy that 105 of the 131 apoptotic cells (Q.aa and Q.pp), respectively ( Figure 1A ). (elifesciences.org)
QL or QR neuroblast each generates three neurons and two apoptotic cells (Q.aa/Q.pp, X). QL produces PQR, PVM, and SDQL. (elifesciences.org)
This results in profound, long-lasting anticancer activity of KP2156 against CT26 colon cancer tumors based on cell cycle arrest and apoptotic cell death. (microbial-ecology.de)

Toxin-antitoxin genes are often inherited through horizontal gene transfer and are associated with pathogenic bacteria, having been found on plasmids conferring antibiotic resistance and virulence. (wikipedia.org)
In fact, amplification of genes by over replication of certain regions of DNA is one of the primary mechanisms by which cancer cells become resistant to drug therapy. (nih.gov)
the development of T cells, we generated a mouse strain having a disruption in both CD3 and CD3 genes (CD3? (tech-strategy.org)
The majority of inherited breast and ovarian cancers are caused by germline mutations of the BRCA1 and BRCA2 genes [ 1 ]. (ijbs.com)
The transcripts of most expressed genes, in a variety of cell types, were shown to be methylated, indicating that m6A modifications are widespread. (pharmaceuticalintelligence.com)
We use basic and clinical research to understand the cells, proteins, and genes that lead to successful recovery of function, and also how complications develop that impact quality of life after stroke. (stanford.edu)

Similarly, the ataR antitoxin encoded on the chromosome of E. coli O157:H7 is able neutralize the ataTP toxin encoded on plasmids found in other enterohemorragic E. coli. (wikipedia.org)
As each chromosome contains a single centromere, it remains unclear how acentric fragments derived from shattered chromosomes are inherited between daughter cells during mitosis 6 . (nature.com)
The stochastic inheritance of chromosome fragments by both newly formed daughter cells could in part contribute to the alternating DNA copy-number states that are characteristic of chromothripsis 2 . (nature.com)
[5] In animal cells, chromosomes reach their highest compaction level in anaphase during chromosome segregation . (wikipedia.org)
Some use the term chromosome in a wider sense, to refer to the individualized portions of chromatin in cells, either visible or not under light microscopy. (wikipedia.org)
In his famous textbook The Cell in Development and Heredity , Wilson linked together the independent work of Boveri and Sutton (both around 1902) by naming the chromosome theory of inheritance the Boveri-Sutton chromosome theory (the names are sometimes reversed). (wikipedia.org)

Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
The function of histone modifying epigenetic regulators and noncoding RNA as central mediators of epithelial stem cell renewal and differentiation represent major emerging areas of study in the lab. (stanford.edu)
Asymmetric cell divisions (ACDs) generate two daughter cells with identical genetic information but distinct cell fates through epigenetic mechanisms. (elifesciences.org)
However, the process of partitioning different epigenetic information into daughter cells remains unclear. (elifesciences.org)
We suggest that asymmetric segregation of V-ATPase may cause distinct acidification levels in the two daughter cells, enabling asymmetric epigenetic inheritance that specifies their respective life-versus-death fates. (elifesciences.org)
Nevertheless, the extent to which epigenetic information is asymmetrically inherited through ACD in other organisms and the mechanism by which this process occurs remains elusive. (elifesciences.org)
The opposing cell fates of daughter cells, i.e., to live or die, offer a compelling experimental system for investigating how epigenetic inheritance determines life versus death decisions during ACD. (elifesciences.org)
These results suggest a role for DNA replication in patterning epigenetic information in asymmetrically dividing cells in multicellular organisms. (sdbonline.org)

While CTCF is essential for embryonic development, little is known of its absolute requirement in somatic cells and the consequences of CTCF haploinsufficiency. (preprints.org)

Overall, these results suggest that tumors are unlikely to arise directly from BRCA2 heterozygous cells without other genetic events such as loss of the wild-type BRCA2 allele and/or loss of p53 function or other cell cycle inhibitors. (ijbs.com)
T cell homing to tumors detected by 3D-coordinated positron emission tomography and magnetic resonance imaging. (mdc-berlin.de)

This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
dual mutant mice, intrathymic advancement HBGF-4 is normally arrested on the DN Compact disc44 completely?CD25+ prothymocyte stage, a central check point of which pre-TCR begins to mediate further thymocyte differentiation into the DP stage. (tech-strategy.org)
Studies in recent years have demonstrated that long non-coding RNAs (lncRNAs) have multiple biological functions in cell growth, differentiation and proliferation. (oncotarget.com)
Although lncRNAs cannot encode any functional protein, they are involved in diverse biological processes, playing essential roles in maintaining cell growth, differentiation and proliferation [ 13 - 15 ]. (oncotarget.com)
As a consequence, cell fate acquisition and subsequent differentiation of endosperm tissues are affected to varying degrees of severity. (biologists.com)
The sym-triazine derivatives were well tolerated by these Nirogacestat cells and promoted beneficial effects on human neurons, upregulating expression of synaptophysin, a synaptic marker protein, and MAP2, a neuronal differentiation marker. (pdgfrsignals.com)

In contrast to mice deficient in CH5424802 biological activity either CD3 or CD3 chains, early thymic development mediated by pre-TCR is completely clogged, and TCR-+ or TCR-+ T cells were absent in the CD3? (tech-strategy.org)
Fig.11 and ?and44 and em B /em , T cells were absent in the thymus and periphery of Compact disc3? (tech-strategy.org)

In this study, we examined the antitumor effects of GS-002 in human hepatoma Hep3B and HepG2 cells in vitro . (hindawi.com)
The therapy consists of harvesting bone marrow stem cells from the patients and using CRISPR/Cas9 technology in vitro to make them produce fetal hemoglobin. (sg-bio.com)
The latter encompass human skin regenerated on immune deficient mice as well as organotypic constructs with epithelial and stromal cells embedded within architecturally faithful mesenchyma in vitro. (stanford.edu)

Therefore, these analyses indicate that deficiency in CD3 and blocked T cell advancement beyond the CD8+ stage completely. (tech-strategy.org)
During tumor development, inherited and/or sporadic TP53 genetic missense mutations are normally followed by a loss of heterozygosity (LOH), turning into an entire p53 deficiency. (encyclopedia.pub)
Increased expression of p53 in the mimicked heterozygous cells was observed, perhaps in response to BRCA2 deficiency. (ijbs.com)

Here we tracked micronucleated chromosomes with live-cell imaging and show that acentric fragments cluster in close spatial proximity throughout mitosis for asymmetric inheritance by a single daughter cell. (nature.com)

Inactivation of CIP2A-TOPBP1 caused acentric fragments to disperse throughout the mitotic cytoplasm, stochastically partition into the nucleus of both daughter cells and aberrantly misaccumulate as cytoplasmic DNA. (nature.com)
Mitotic clustering drives the unequal inheritance of acentric fragments by a single daughter cell, providing an explanation for the origins of distinct patterns of chromothripsis found across diverse cancer types and congenital disorders. (nature.com)
Centrosomes nucleate the formation of the microtubule cytoskeleton in interphase cells and form the poles of the mitotic spindle during cell division. (elifesciences.org)

PGM1 inhibits hepatocellular carcinoma cell (HCC) proliferation and growth by utilizing sufficient extracellular glucose to convert glycogen, while deletion of the PGM1 gene inhibits glycogen synthesis and leads to glycolysis of additional glucose, thus promoting tumor cell proliferation and growth [ 15 ]. (biomedcentral.com)
The proliferation and growth of PDAC cells were detected by Celigo analysis, MTT, and clone formation assay. (jcancer.org)

Therefore, the overall goal of our work is to discover how DNA replication is regulated both in the large chromosomes of cells and in the "mini-chromosomes" of viruses and small extrachromosomal DNA molecules. (nih.gov)
We used isolated nuclei from virus infected cells supplemented with cytoplasm, and discovered that viral replicating chromosomes could continue replication in the absence of a nucleus. (nih.gov)
Chromosomes are normally visible under a light microscope only during the metaphase of cell division (where all chromosomes are aligned in the center of the cell in their condensed form). (wikipedia.org)
Each cell in our bodies contains over two meters of DNA, which is divided into 46 packages of information called chromosomes. (elifesciences.org)
This means that they also need to copy all of their DNA and then deliver identical sets of chromosomes to each new cell. (elifesciences.org)
Animal cells use structures called centrioles to help them divide their sets of chromosomes accurately. (elifesciences.org)
if too many or too few centrioles are built, cell division errors can occur that lead to the generation of new cells with abnormal numbers of chromosomes. (elifesciences.org)

Drugs that block DNA replication can arrest the spread of cancer cells and eliminate viral pathogens. (nih.gov)
Part of the innate immune system that is the body s first line defense against infection, dendritic cells sense the presence of pathogens in the blood or other tissues, ingest infecting organisms, and then display fragments of the invaders on their surface, which alerts and activates both killer and helper T cells (CD4 and CD8 cells), essentially teaching them to target the specific pathogen. (regenerativemedicine.net)
It has also been reported that trophoblast cells can phagocytose pathogens and that this activity is enhanced by IFN-γ treatment17. (techieindex.net)
These family proteins are known to play critical roles in mediating specific resistance to intracellular pathogens including protozoa bacteria and viruses18 19 20 Because IGTP localizes predominantly to the endoplasmic reticulum it is assumed to be involved in the processing and trafficking of immunologically relevant proteins21 22 IGTP has been found to be essential for host resistance to acute infections by the protozoans into TG cells. (techieindex.net)
Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens cell damage or irritants. (techieindex.net)

GS-002 also induced endoplasmic reticular (ER) stress as evidenced by increases in ER stress-responsive proteins including glucose-regulated protein 78 (GRP78), growth arrest- and DNA damage-inducible gene 153 (GADD153), phosphorylated eukaryotic initiation factor 2 α (eIF2 α ), phosphorylated protein endoplasmic-reticular-resident kinase (PERK), and ATF-3. (hindawi.com)
in eukaryotic cells the most important of these proteins are the histones . (wikipedia.org)
A single-stranded DNA-binding protein that is found in EUKARYOTIC CELLS. (lookformedical.com)

A deoxyribonucleotide polymer that is the primary genetic material of all cells. (lookformedical.com)
The results presented by Moyer and Holland help us to understand how dividing cells build the complex machinery that enables them to pass on their genetic material accurately. (elifesciences.org)
When HIV infects a cell it first injects its genetic material RNA in this case into the cell along with the reverse transcriptase enzyme that transcribes the single-strand RNA molecule into a double-stranded DNA molecule. (regenerativemedicine.net)

The effect of heterozygosity of the BRCA2 gene on human cells remains unclear. (ijbs.com)
Several molecular mechanisms involved in phagocytosis by trophoblast cells have been reported16 however the complete process remains unclear. (techieindex.net)

An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. (lookformedical.com)
Pattern formation in the embryo is severely impaired with development arresting at premature stages, while in the endosperm, the effects of the glo1-1 mutation are manifest at the free-nuclear or syncytial stage. (biologists.com)

My laboratory has developed new technologies and applied them towards understanding the molecular biology and enzymology of DNA replication in animal cells and viruses (SV40, polyomavirus, papillomavirus, and herpes simplex virus), and at the beginning of animal development (mouse preimplantation embryos and frog eggs). (nih.gov)
ebook the giraffe biology ecology evolution books: molecules which line a hormone embodied in the inherited monomethanesulfonate. (siriuspixels.com)
The complexity of the sphingolipidome is hard to imagine, but one hopes that, when partnered with other systems biology approaches, the causes and consequences of the complexity will explain how these intriguing compounds are involved in almost every aspect of cell behavior and the malfunctions of many diseases. (sphingolipidclub.com)

When these systems are contained on plasmids - transferable genetic elements - they ensure that only the daughter cells that inherit the plasmid survive after cell division. (wikipedia.org)

This is because some tumor cells are able to bind to the PD-1 protein to block the immune response against cancer. (sg-bio.com)
Furthermore, the effect of PYCR1 interference on tumor growth was evaluated in vivo through injecting tumor cells subcutaneously into nude mice. (jcancer.org)

The blood disorders beta-thalassemia and sickle cell disease, which affect oxygen transport in the blood, are the target of a CRISPR/Cas9 treatment. (sg-bio.com)

Should one of these plasmids encode for a TA system, its "displacement" by another TA-free plasmid system will prevent its inheritance and thus induce post-segregational killing. (wikipedia.org)

A cell that would carry two plasmids from the same incompatibility group will eventually generate two daughters cells carrying either plasmid. (wikipedia.org)
Because of this critical role of dendritic cells, the investigators explored the hypothesis that dendritic cells of elite controllers were better able to sense HIV and as a result to generate virus-specific T-cell responses. (regenerativemedicine.net)

Our current research now focuses on two basic, interrelated questions: (1) How do mammalian cells decide where and when to initiate DNA replication? (nih.gov)
In the past, our research focused on viral genomes as models for DNA replication in mammalian cell nuclei. (nih.gov)
In most people, HIV infection of dendritic cells appears to be blocked at an early stage, resulting in a lack of HIV DNA and limited viral replication within those cells. (regenerativemedicine.net)
In our previous study we demonstrated that abortion-inducing bacteria in human and animals such as and infection we found that there was a higher degree of bacterial colonization LY404187 in the placenta than in other organs that there were many bacteria in trophoblast giant (TG) cells in the placenta and that abortion was not induced in an intracellular replication-defective mutant11. (techieindex.net)

The control of this transition from epithelial stem cell to differentiated corneocyte, which is abnormal in epidermal cancers, is not well understood. (stanford.edu)

These results demonstrate a mixed unbiased transcriptomic, proteomic, and immunomic strategy identifies a significantly broadened repertoire of proteins antigens targeted by T cells involved with allergy pathogenesis. (enmd-2076.com)
Interestingly, the growth rate of the mimicked BRCA2 heterozygous cell line was significantly lower than that of control cells. (ijbs.com)
Pregnancy qualified prospects to a generalized suppression from the adaptive immune system typified by significantly decreased cell-mediated immunity and reduced T helper cell (Th) 1 responsiveness4 5 This immunosuppressed state prevents maternal rejection of the fetus but has the unfortunate consequence of increasing maternal susceptibility to certain infectious agents6 7 Immunity against is principally mediated by cellular immune responses because it is an intracellular pathogen8. (techieindex.net)

Enriched monolayer precursor cell cultures from micro-dissected adult mouse dentate gyrus yield functional granule cell-like neurons. (mdc-berlin.de)

The effect of the promoter variant was further studied by luciferase gene reporter assay in MCF-7, HEK293, HeLa and LNCaP cell lines. (biomedcentral.com)
Luciferase reporter gene assay of the promoter construct bearing this variant did not suggest a variation of expression in the MCF-7 breast cancer cell line, but indicated a reduction of luciferase expression in both the HEK293 and LNCaP cell lines. (biomedcentral.com)

The finding of proteins that creates Th2 cells but aren't IgE reactive may permit the advancement EI1 of safer immunotherapeutic strategies. (enmd-2076.com)
Although occasionally it's been demonstrated that T cells can only just or preferentially offer help B cells particular for the same proteins (17, 18), in additional systems this limitation was not the situation (19, 20). (enmd-2076.com)
It had been discovered that two protein that can be found on a single particle could function collectively which T cells particular for one proteins could offer help for B cells particular for the next proteins (20). (enmd-2076.com)
When cells are about to divide, they make a new set of centrioles by assembling a variety of proteins. (elifesciences.org)

Relating to this idea, particular B cells internalize and procedure the antigen, resulting in the demonstration of antigen fragments destined by surface area MHC course II molecules that may be recognized EI1 by particular T cells guaranteeing how the T cells deliver help B cells particular for the same antigen (connected help). (enmd-2076.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Identified in bacterial rRNAs and tRNAs as early as the 1950s, this type of methylation was subsequently found in other RNA molecules, including mRNA, in animal and plant cells as well. (pharmaceuticalintelligence.com)

Additionally, our data suggest that acquisition of aleurone cell fate does not solely rely upon signalling from the maternal surrounding tissue to the periphery of the endosperm, as previously thought, but that other factor(s) present within the endosperm are involved. (biologists.com)

Furthermore, data from human being studies have proven too little relationship between antigen-specific IgE amounts and T-cell reactions (12C16). (enmd-2076.com)
The problem of whether T-cell reputation can be always necessarily associated with antibody recognition offers broader significance with regards to the classic idea of linked reputation of the antigen by both T helper cells and antigen-specific B cells. (enmd-2076.com)
All of us reveal that in a roundabout way stimulated APCs market antigen-specific expansion involving unsuspicious CD8(+) T cells however neglect to assist their tactical and also cytotoxic Capital t lymphocyte difference. (ap24534inhibitor.com)

During implantation trophoblast cells invade maternal tissue by phagocytosing uterine epithelial cells and stroma15. (techieindex.net)

Used together, these scholarly research showed that Compact disc3 and Compact disc3 play an important, yet overlapping partially, role in the introduction of both and T cell CH5424802 biological activity lineages. (tech-strategy.org)
These observations are consistent with the biological evidence that in mature T cells, the TCRC CD3 complex lacking either CD3 or could sometimes be detected on the cell surface at reduced levels. (tech-strategy.org)
By performing cell biological and biochemical experiments using human cells, Moyer and Holland show that PLK4 interacts with a protein called STIL that is found in the central part of the centriole. (elifesciences.org)
In the present study, diverse cell biological and analytical tools such as laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS), isotope labeling, and nano-scale secondary ion mass spectrometry (NanoSIMS) were employed to better understand the distribution and activation process of KP2156 (in comparison to free oxaliplatin and a non-albumin-binding succinimide analogue). (microbial-ecology.de)

Organisms usually contain large numbers of sphingolipid subspecies (for a pathway based compilation, see www.sphingomap.org) and knowledge about the types and amounts is imperative because they influence membrane structure, interactions with the extracellular matrix and neighboring cells, vesicular traffic and the formation of specialized structures such as phagosomes and autophagosomes, as well as participate in intracellular and extracellular signaling. (sphingolipidclub.com)

Skin malignancies, including epidermal squamous cell carcinoma (SCC), alone account for nearly as many cancers as all other tissues combined. (stanford.edu)
CircPAPD4 expression was low in BC tissues and cells. (biomedcentral.com)

V-ATPase interacts with NuRD and is asymmetrically segregated into the surviving daughter cell. (elifesciences.org)

Cancers, in particular haematological malignancies, are common adverse events in patients with NBS, as almost 40% of them develop a malignancy before the age of 21 years, and this correlates with a marked impairment in DSB repair observed in cells from these patients [ 5 ]. (biomedcentral.com)

The General Control Nonderepressible 2 (GCN2) kinase is a conserved member of the integrated stress response (ISR) pathway that represses protein translation and helps cells to adapt to conditions of nutrient shortage. (biomedcentral.com)
The induction of ATF-3 expression was mediated by mitogen-activated protein kinase (MAPK) signaling pathways in GS-002-treated cells. (hindawi.com)
This protein found on the surface of immune cells is the target of some cancer drugs such as checkpoint inhibitors. (sg-bio.com)
Among these four studies, the same 53kD protein (called p53) was detected-and confirmed with peptide maps-in SV40-transformed cells and malignant cells that are not transformed by a virus, whereas decreased p53 levels were observed in uninfected normal cells. (encyclopedia.pub)
A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the cell cycle. (lookformedical.com)
The modification of STIL at a specific location by PLK4 was needed to link it to another protein in the outer wall of the centriole, and was also necessary for the cells to build new centrioles. (elifesciences.org)
The dendritic cells of elite controllers, however, were found to contain higher levels of HIV DNA, probably because of limited expression of a protein called SAMDH1 that usually blocks reverse transcription in several types of immune cells. (regenerativemedicine.net)
The dendritic cells of elite controllers also appear to produce higher levels of a DNA-sensing protein called cGAS that recognizes the presence of HIV and induces rapid expression of type 1 interferons. (regenerativemedicine.net)

Reactions against the dominating undescribed epitopes had been from the memory space T-cell subset and may even be recognized directly former mate vivo after Th2 cell enrichment. (enmd-2076.com)

Cell counting kit-8 (CCK-8) assay was used to evaluate the effect of OPD and OPD' on H9c2 cell viability. (bvsalud.org)

Sequencing of daughter cell pairs derived from micronucleated mother cells demonstrated that complex rearrangements are indeed a common outcome of micronucleus formation. (nature.com)

Others use the concept in a narrower sense, to refer to the individualized portions of chromatin during cell division, visible under light microscopy due to high condensation. (wikipedia.org)
During cellularisation,and at later stages of development, aberrant cell division and localised domains of cell proliferation are apparent in glo1-1 endosperms. (biologists.com)
Control of cell division and expansion is crucial for developmental patterning and is likely to be mediated by factors operating at different organisational levels ( Irish and Jenik,2001 ). (biologists.com)
This suggests that the modification of STIL by PLK4 is important for normal cell division across different species. (elifesciences.org)

Our results suggested that IGTP induces the activation of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway and promotes bacterial invasion into TG cells. (techieindex.net)

ATF-3 induces DNA synthesis and expression of cyclin D1 in hepatocytes [ 21 ] and is involved in serum-induced cell proliferation as a target gene of c-myc [ 10 ]. (hindawi.com)

In this report, we have utilized HT-29 colon cancer cells and have mimicked the heterozygous state of BRCA2 in these cells through RNA interference. (ijbs.com)

In support of this notion, cells lacking a functional BRCA2 gene show hypersensitivity to DNA damaging agents such as mitomycin C (MMC) and sensitivity to chemicals such as methyl methane sulfonate [ 10 ]. (ijbs.com)

Malignant cells that were not transformed by any virus also had increased levels of p53, suggesting that the SV40 tumor antigen, a well-known factor for the tumor initiation and progression, binds to p53 and raises its concentration above its normal levels in control healthy cells [ 10 ] . (encyclopedia.pub)
KP2156 forms very stable albumin adducts in the bloodstream resulting in a superior pharmacological profile, such as distinctly prolonged terminal excretion half-life and enhanced effective platinum dose (measured by ICP-MS). The albumin-bound drug is accumulating in the malignant tissue, where it enters the cancer cells clathrin- and caveolin-dependent endocytosis, and is activated by reduction to release oxaliplatin. (microbial-ecology.de)

mazEF, a toxin-antitoxin locus found in E. coli and other bacteria, was proposed to induce programmed cell death in response to starvation, specifically a lack of amino acids. (wikipedia.org)
This method provides a reference for future research on the screening of binding sites of photosensitizers to cells and bacteria. (bvsalud.org)

In experiments on isolated cells and in animals with urinary tract and other infections, the addition of CRISPR-Cas3 makes phages much more effective at killing E. coli . (sg-bio.com)
In experiments using dendritic cells from elite controllers, from patients with progressing HIV infection, and cells from uninfected individuals, the investigators found a surprising difference. (regenerativemedicine.net)

Both extrinsic and intrinsic mechanisms determine distinct daughter cell fates after ACD. (elifesciences.org)
Illustration: Cell intrinsic responses against HIV-1 in conventional dendritic cells from Elite Controllers. (regenerativemedicine.net)

Based on our findings, however, we propose that specification of BETL cells is an irreversible event that occurs within a narrow window of syncytial development, and that BETL cell identity is subsequently inherited in a lineage-dependent manner. (biologists.com)
Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4). (elifesciences.org)

Hat1 is implicated in chromatin assembly and DNA repair but its role in cell functions is not clearly elucidated. (sdbonline.org)

Ongoing projects focus on glial cells (astrocytes and microglia) and how they coordinate with immune cells from the blood to affect bystander brain injury in the days after stroke. (stanford.edu)

Here, BRCA2 heterozygosity was mimicked in HT-29 colon cells by reducing levels of BRCA2 through stable RNA interference. (ijbs.com)
In support of this hypothesis, heterozygosity for a BRCA2 mutation has been shown to cause sensitivity to DNA damage agents and reduced RAD51 focus formation after irradiation in the chicken B cell line DT40 [ 16 ]. (ijbs.com)

Levels of p27 were also found to be slightly increased in cells with reduced BRCA2, perhaps contributing to the slower growth rate. (ijbs.com)

These studies suggested that trophoblast cells play a role not only in the development and maintenance of placenta but LY404187 also in the placental defense system. (techieindex.net)

In breast cancer, ATF-3 enhances cancer cell-initiating features [ 22 ] and is associated with activation of the canonical Wnt/ β -catenin pathway [ 23 ]. (hindawi.com)

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