Cells were treated with sodium arsenite. Medical search. Frequent questions

A dose-related effect was observed: highest concentration (10-2 µM sodium arsenite) induces 28.33 and 22.4% hyperploid cells in first and second division respectively and 29% tetraploid cells. (europa.eu)
An in vitro gene mutation assay was conducted with sodium arsenite in the supF gene of pZ189 shuttle vector system in DNA repair proficient GM0637 human fibroblasts to determine whether arsenic alone induces mutation and whether the combination of arsenic and UV irradiation leads to a yield of mutants greater than the sum of the arsenic or UV treatments alone. (europa.eu)
The purpose of this study was to determine if estrogen receptor β (ERβ), the predominant estrogen receptor in lung tissue, induces activation of ERK1/2 upon stimulation with cadmium and arsenite. (bellarmine.edu)

The differential effects of arsenic compounds and the effect of selenium on arsenic-induced changes in cytotoxicity, viability, and cell cycle of porcine aorta endothelial cells (PAECs) were investigated. (asia.edu.tw)
This study characterizes the response of primary human endothelial cells (human umbilical vein endothelial cells, HUVECs) to the relative shear stress changes that occur during the initiation of arteriogenesis at the entrance regions to a collateral artery network. (refine.bio)
Whereas endothelial cells plated on fibronectin or fibrinogen activate NF-κB in response to flow, cells on collagen or laminin do not. (rupress.org)

In an in vitro mammalian cell gene mutation test performed similarly to OECD guideline 476, L5178Y/ TK+/- mouse lymphoma cells were exposed to sodium arsenate at concentrations of 26, 34, 46, 61 and 81 μg/mL in the absence of metabolic activation and the exposure duration was 3 hours. (europa.eu)
No significant increases in mutant frequency were observed following treatment of sodium arsenate in the absence of metabolic activation. (europa.eu)
Under the test conditions, sodium arsenate is not considered as mutagenic in mouse lymphoma L5178Y cells. (europa.eu)
MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay indicated that arsenic trioxide (As(2)O(3)) and sodium arsenite (NaAsO(2)) showed similar cytotoxicity, whereas sodium arsenate (Na(2)HAsO(4)) did not show cytotoxicity in PAECs. (asia.edu.tw)
Relative effects of arsenate on sodium, phosphate, and glucose transport by the rabbit proximal tubule. (springer.com)

In Chinese hamster cells, arsenite did not induce ouabain-resistant mutants or thioguanine-resistant mutants. (europa.eu)
Previous studies have shown that these two heavy metals can induce cellular proliferation and activate phosphorylation of ERK1/2 in a human lug adenocarcinoma cell line, NCI-H1793. (bellarmine.edu)
These results support that cadmium chloride and sodium arsenite induce phosphorylation of ERK1/2 as expected. (bellarmine.edu)

We hypothesize that chronic exposure of "a physiologically relevant" level of arsenite disrupts the EGFR endocytic trafficking. (louisville.edu)
In conclusion, the impact of chronic arsenite exposure on the EGFR signaling axis can explain arsenite-induced overexpression of the EGFR. (louisville.edu)
Furthermore, the exposure to AMH exerted a stimulatory effect on HOb cells leading to the activation of osteogenic genes, including the upregulation of osteoblastic transcription factors such as RUNX and OSX, along with increased deposition of mineralized nodules. (bvsalud.org)
TO demonstrated a dose-dependent decrease in viability of A549 cells after 24 h of exposure. (jcimjournal.com)
Cell proliferation was reduced in a time-dependent manner of drug exposure as revealed from BrdU incorporation and migration studies. (jcimjournal.com)
Ingestion is the main route of exposure to other arsenites and arsenates for the general population. (cdc.gov)

To evaluate upregulation of hST8Sia I gene during MG-63 cell differentiation by serum starvation, promoter area of the hST8Sia I gene was functionally analyzed. (bvsalud.org)
We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs. (go.jp)

An increased G2/M phase was observed in NaAsO(2)-treated PAECs, whereas an increase in secondary necrosis (late apoptosis) was observed in As(2)O(3)-treated PAECs. (asia.edu.tw)
Sodium selenite (Na(2)SeO(3)) at 1 nM reduced 20 microM As(2)O(3)-induced cytotoxicity, but not apoptosis, at 24 h. (asia.edu.tw)
The global expression profile of Tcf-1 deficient progenitors indicates that basic processes of DNA metabolism are downregulated in its absence and the blocked T-cell progenitors become abortive and die by apoptosis. (refine.bio)
The ability of the host to trigger apoptosis in infected cells is perhaps the most powerful tool by which viruses can be cleared from the host organism. (mdpi.com)
To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and intrinsic apoptosis. (mdpi.com)
In this manuscript, we review the current literature regarding how HPV-infected cells avoid apoptosis and the molecular mechanisms involved in these events. (mdpi.com)
Many of the current efforts regarding anti-cancer drug development are focused on directing tumor cells to undergo apoptosis. (mdpi.com)
Fluorescence-activated cell sorting analysis after annexin V-fluorescein isothiocyanate and propidium iodide (annexin V-FITC-PI) dual staining method was done to ascertain early stage of apoptosis, if any. (jcimjournal.com)
Annexin-V-FITC positivity of cells up to 11.72% as compared to the untreated control revealed early state of TO-induced apoptosis. (jcimjournal.com)
The aim of this study is to investigate the effects and possible mechanisms of sodium ferulate (SF) on anti- apoptosis in steroid-induced femoral head osteonecrosis in rabbit s. (zju.edu.cn)
α-lipoic acid inhibits TNF-α-induced apoptosis in human bone marrow stromal cells. (zju.edu.cn)

In an in vitro chromosomal aberration assay conducted similarly to OECD Guideline 473, whole blood cultures were incubated for 72 hours and treated with various concentrations (1-10-10 µM) of sodium arsenite for the last 24 hours. (europa.eu)
Promoter analysis using luciferase reporter assay system harboring various constructs of the hST8Sia I gene proved that the cis-acting region at -1146/-646, which includes binding sites of the known transcription factors AP-1, CREB, c-Ets-1 and NF-κB, displays the highest level of promoter activity in response to serum starvation in MG-63 cells. (bvsalud.org)
The -731/-722 region, which contains the NF-κB binding site, was proved to be essential for expression of the hST8Sia I gene by serum starvation in MG-63 cells by site-directed mutagenesis, NF-κB inhibition, and chromatin immunoprecipitation (ChIP) assay. (bvsalud.org)
The ToxTracker assay is a panel of six validated GFP-based mouse embryonic stem (mES) reporter cell lines that can be used to identify the biological reactivity and potential carcinogenic properties of compounds in a single test. (europa.eu)
ToxTracker is a mammalian stem cell-based assay that monitors activation of specific cellular signalling pathways for detection of the biological reactivity of compounds. (europa.eu)
Cell viability was ascertained through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay after deployment of TO in different doses. (jcimjournal.com)
Effects of Thuja occidentalis ethanolic extract on viability of A549 cell line (A) and L-132 cell line (B) Cells were exposed to Thuja occidentalis ethanolic extract for 24 h at different concentrations and the cell viability was determined by MTT assay. (jcimjournal.com)
Effects of Thuja occidentalis ethanolic extract on cellular proliferation tested by BrdU incorporation assay Cells were exposed to three different concentration of Thuja occidentalis ethanolic extract for 6, 12 and 24 h along with incorporation of BrdU. (jcimjournal.com)
A) Neurons treated with α-syn species and assessed for cell viability by MTT assay. (qpsneuro.com)

Patients with acute promyelocytic leukemia (APL) treated with arsenic trioxide have experienced symptoms of differentiation syndrome, which may be life-threatening or fatal. (nih.gov)
Monitor patients with severe hepatic impairment (Child-Pugh Class C) for toxicity when treated with arsenic trioxide. (nih.gov)
Then we investigated the demethylating effect of arsenic trioxide and 5-azacitidine on the mRNA and protein expression levels of GRHL2 in cell lines of acute leukemia. (hindawi.com)
The methylation level of the GRHL2 promoter region in acute leukemia patients and cell lines was significantly higher than the normal control group, and we found the elevated mRNA and protein levels of GRHL2 in acute leukemia cell lines after the use of the demethylation drug arsenic trioxide and 5-azacitidine. (hindawi.com)

Induced phosphorylation of ERK1/2 by these compounds is decreased in the presence of an estrogen receptor antagonist, ICI-182,780, suggesting that cadmium and arsenite stimulate these responses, in part, via a non-genomic estrogen signaling pathway. (bellarmine.edu)
The inhibition of Torc1 by rapamycin mimics nutrient starvation and causes an array of physiological changes that include global changes in gene expression, phosphorylation/dephosphorylation of various factors, decreased cell growth, degradation of proteins, and ultimately cell cycle arrest in the G 1 phase [4, 9-11]. (researchsquare.com)

From these results, it has been suggested that transcription activity of hST8Sia I gene by serum starvation in human osteosarcoma MG-63 cells is regulated by p38MAPK/NF-κB signaling pathway. (bvsalud.org)
Together, the results indicate that arsenic disrupted the circulating levels of gonadotropins and estradiol, led to degeneration of luminal epithelial, stromal and myometrial cells of the rat uterus and downregulated the downstream components of the estrogen signaling pathway. (biomedcentral.com)
In yeast, rapamycin inhibits the TORC1 kinase signaling pathway causing rapid alteration in gene expression and ultimately cell cycle arrest in G 1 through mechanisms that are not fully understood. (researchsquare.com)
Finally, we studied the effects of arsenide trioxide and 5-azacitidine on the proliferation of leukemia cells and the TGF- β signaling pathway. (hindawi.com)
At the same time, arsenide trioxide and 5-azacitidine are associated with the inhibition of cellular proliferation of acute leukemia cells and also promote the elevated expression of TGF- β signaling pathway-linked proteins, including TGF- β , Smad2, Smad3, and Smad4. (hindawi.com)

The goal of this project is to identify molecular mechanisms and roles of chronic arsenite-induced EGFR overexpression in lung cancer development. (louisville.edu)
In the present study, we investigated the effect of arsenite on the expression of TF in human aortic smooth muscle cells (HASMCs) and the underlying molecular mechanisms. (go.jp)
It remains elusive, which alternative mechanisms the cell employs to regulate translation during adverse environmental stress. (prolekarniky.cz)
Three mechanisms have been proposed for the role of glutathione (GSH) in regulating cisplatin (CDDP) sensitivities that affects its ultimate cell-killing ability: (i) GSH may provide as a cofactor in facilitating multidrug resistance protein 2- (MRP2-) mediated CDDP efflux in mammalian cells, since into HEK-293 cells conferred CDDP resistance (10-fold) in the transfected cells [16]. (healthanddietblog.info)
Possible mechanisms for overcoming the resistance of HPV-infected tumor cells to anticancer drugs will be discussed. (mdpi.com)
In different immune cell types, each MiT family member is shown to play distinct or redundant roles and we expect that there is far more to learn about their functions and regulatory mechanisms in host defense and inflammatory responses. (molcells.org)
While more research is still needed to fully understand the role these cells play in aging and disease, Loane and his team's work represents a significant step forward in our understanding of some of the underlying mechanisms of neurodegeneration. (qpsneuro.com)

Some wood is treated with copper arsenates as a preservative. (wikipedia.org)

Sodium arsenite was tested at the concentrations of 1, 2.5 and 5.0 µM in GM 637 human fibroblasts for 72 hours and plasmid was irradiated with 320 J/m2. (europa.eu)
NCI-H1793 adenocarcinoma lung cells were treated with the ERβ antagonist, PHTPP, before cells were treated for ten minutes with nanomolar concentrations of 17β-estradiol, cadmium chloride, or sodium arsenite. (bellarmine.edu)
In the resveratrol + As 2 O 3 -treated group, activities of glutathione peroxidase, catalase, and superoxide dismutase, the ratio of reduced glutathione to oxidized glutathione, the total arsenic concentrations, and the percentage of methylated arsenic in urine were significantly increased. (springer.com)
The concentrations of renal malondialdehyde, reactive oxygen species, 8-hydroxydeoxyguanosine, serum creatinine, blood urea nitrogen, and renal arsenic accumulation were significantly decreased and reduced renal morphologic injury was observed compared with the As 2 O 3 -treated group. (springer.com)

Environmental stress or suboptimal growth conditions reduce cell viability and put cells at risk. (prolekarniky.cz)
While monomeric human α-syn has no impact on cell viability, preformed wild type and A53T human α-syn fibrils have toxic effects on primary cortical neurons. (qpsneuro.com)

Estrogen is involved in the proliferation of adenocarcinoma lung cells. (bellarmine.edu)
Involved in positive regulation of biosynthetic process and positive regulation of glomerular mesangial cell proliferation. (mcw.edu)

The benefits of this extra step are apparent in multiplexing/multicolor-staining experiments (e.g., flow cytometry) where there is potential cross-reactivity with other primary antibodies or in tissue/cell fluorescent staining experiments where there are may be the presence of endogenous immunoglobulins. (thermofisher.com)
Tissue factor (TF) is the initiator of the coagulation cascade, constitutively expressed in subendothelial cells such as vascular smooth muscle cells and initiating rapid coagulation when the vascular vessel is damaged. (go.jp)
Chen B, Arnold LL, Cohen SM, Thomas DJ, Le XC (2011) Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water. (springer.com)

However, the proliferative role of two endocrine disrupters, cadmium chloride and sodium arsenite, in lung adenocarcinoma is less clear. (bellarmine.edu)
To study the possible anticancer and antiproliferative activities of ethanolic leaf extract of Thuja occidentalis (TO) on A549 non-small lung carcinoma cells in vitro . (jcimjournal.com)

ToxTracker consists of a panel of six different mES GFP reporter cell lines representing four distinct biological responses that are associated with carcinogenesis, i.e. general cellular stress (biomarker gene: Btg2), DNA damage (biomarker genes: Bscl2 and Rtkn), oxidative stress (biomarker genes: Srxn1 and Blvrb) and protein damage (biomarker gene: Ddit3). (europa.eu)

In this study, we have firstly elucidated that serum starvation augmented the levels of human GD3 synthase (hST8Sia I) gene and ganglioside GD3 expression as well as bone morphogenic protein-2 and osteocalcin expression during MG-63 cell differentiation using RT-PCR, qPCR, Western blot and immunofluorescence microscopy. (bvsalud.org)
Knockdown of hST8Sia I using shRNA suggested that expressions of hST8Sia I and GD3 have no apparent effect on differentiation of MG-63 cells. (bvsalud.org)
Activation of Notch signaling in uncommitted precursors by the thymic stroma initiates the T-cell differentiation program. (refine.bio)
It is involved in cell differentiation, maintenance of cell differentiation state, tumorigenesis, and cell senescence, mainly through DNA methylation, histone acetylation, and RNA-related silencing [ 6 ]. (hindawi.com)

Restriction digest and DNA sequencing analyses indicated that arsenite alone produces large-scale rearrangements, frameshifts and base substitutions. (europa.eu)
mRNA microarray analyses of A549, PC14, and PC14CDDP cells that were transiently transfected with either pre-miR-197 or LNA-miR-197 and their controls. (nih.gov)

These results suggest that arsenite promotes TF synthesis by activating the Nrf2 pathway in HASMCs and that the induction of TF expression by arsenite may be related to the progression of atherosclerosis. (go.jp)
Furthermore, altering the extracellular matrix to promote p38 activation in cells on fibronectin suppresses NF-κB activation, suggesting a novel therapeutic strategy for treating atherosclerosis. (rupress.org)

Histological evaluation revealed degeneration of luminal epithelial cells and endometrial glands in response to arsenic treatment, along with reduction in thickness of the longitudinal muscle layer. (biomedcentral.com)

Arsenite did not cause the induction of lambda prophage. (europa.eu)
This promotes induction of epithelial to mesenchymal transition (EMT) and causes the development of squamous cell carcinoma (SCC) of skin. (jcpjournal.org)

J Cell Biol (2005) 169 (1): 191-202. (rupress.org)

In vitro Parkinsonism can be modeled by the administration of MPP+ to different cell culture systems. (qpsneuro.com)

These reporters were created using bacterial artificial chromosomes (BAC) that contain the complete biomarker gene including promoter and regulatory elements ensuring physiological regulation of the GFP reporters following transfection into stem cells (Hendricks, G. et al. (europa.eu)

Cells maintain their internal homeostasis by adequate reprogramming of metabolic activities at all levels of gene expression, including chromatin remodeling, mRNA expression and degradation, translation and protein degradation. (prolekarniky.cz)
Given the considerable time needed to activate new genes and/or de novo synthesize mRNA, the translation of existing mRNAs provides the necessary plasticity for the cell to selectively and rapidly respond to stress [1] , [2] . (prolekarniky.cz)
MRP2 mRNA and proteins levels could be markedly induced by remedies with metalloid salts including sodium arsenite [As(III)] and potassium antimonyl tartrate in principal rat and individual hepatocytes [22]. (healthanddietblog.info)
Secondly, we employed qRT-PCR and Western blotting to detect the mRNA and protein levels of GRHL2 in leukemia cell lines. (hindawi.com)

Concomitantly, downregulation of estrogen receptor (ER alpha), the estrogen-responsive gene - vascular endothelial growth factor (VEGF), and G1 cell cycle proteins, cyclin D1 and CDK4, was also observed. (biomedcentral.com)

The chronic arsenite-treated cells had increased EGFR protein expression levels and activity, increased transcription levels of TGFα, and altered the distribution of the EGFR. (louisville.edu)

2011). Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment. (europa.eu)

Poisson distribution followed by student's t-test was used to assess the effects of sodium arsenite on mutant frequencies. (europa.eu)
Effects of Thuja occidentalis ethanolic extract on A549 cell migration (Light microscopy, ×20) Wound-healing assays were performed to assess cell migration. (jcimjournal.com)

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase localized on the cell surface. (louisville.edu)
While Ishikawa and Ali-Osman [14] in the beginning reported that formation of Pt(GS)2 complex reached a maximal level after 12?hrs in L1210 cells AZD2014 small molecule kinase inhibitor treated with 20?biosynthesis of GSH is controlled from the rate-limiting enzyme, glutamate-cysteine ligase (GCL, also known as with increased cellular GSH levels [34C39]. (healthanddietblog.info)
Our data provide a new insight whereby rapamycin signaling via the Torc1 kinase may exploit the pheromone pathway to arrest cells in the G 1 phase. (researchsquare.com)
The General Control Nonderepressible 2 (GCN2) kinase is a conserved member of the integrated stress response (ISR) pathway that represses protein translation and helps cells to adapt to conditions of nutrient shortage. (biomedcentral.com)

Moreover, the transcriptional activation of hST8Sia I gene by serum starvation was strongly hindered by SB203580, a p38MAPK inhibitor in MG-63 cells. (bvsalud.org)
Although transcriptional programs associated with T-cell specification and commitment have been described, the functional hierarchy and the roles of key regulators in structuring/ orchestrating these programs remain unclear. (refine.bio)

Also, mitotic arrest was evaluated in cultures treated for the last 2 hours. (europa.eu)
Cells were harvested and samples were processed for evaluation of aneuploidogenic and mitotic arrest. (europa.eu)
Herein, we screened a histone mutant collection and report that one of the mutants, H2B R95A, is strikingly resistant to rapamycin due to a defective cell cycle arrest. (researchsquare.com)
Of these mutants, H2B R95A displayed striking resistance to rapamycin, which correlated with an inability to undergo cell cycle arrest. (researchsquare.com)

They play crucial roles in supporting nerve cells, defending against invading microbes, clearing debris, and removing dying nerve cells through phagocytosis. (qpsneuro.com)

There are three known estrogen receptors, but it is unclear which might be utilized by cadmium or arsenite to activate ERK1/2. (bellarmine.edu)

RESULTS: We reported the first evidence for the expression and functionality of AMHRII in HOb cells, thus suggesting that osteoblasts may represent a specific target for exogenous AMH treatment. (bvsalud.org)
The results indicate that targeting damaging, inflammatory sub-populations of microglia could represent a promising new method for treating aging-related diseases. (qpsneuro.com)

QPS Neuropharmacology provides several cell culture models for MPP+ induced Parkinsonism, as primary cortical neurons (Figure), primary rat TH neurons, SH-SY5Y and many more. (qpsneuro.com)

Under the test conditions, sodium arsenite was found to have an aneuploidogenic and a mitotic arrestant effect in cultured human lymphocytes. (europa.eu)
In appreciable limit entailed in which were Xanax Discount Online found in diag^^^^^ ^ind treat- ment in the west side of lunatics. (dwellbycheryl.com)
We found a lower level of GRHL2 expression not only in acute leukemia patients but also in cell lines when compared with normal controls. (hindawi.com)
Microglia are a unique, specialized type of immune cell found in the brain and spinal cord. (qpsneuro.com)

Ethanolic leaf extract of TO demonstrated apoptotic and antiproliferative potentials against A549 cell line. (jcimjournal.com)

0.01) than the yield expected and the greatest potentiation of UV-induced mutations (4.9-fold) was observed at 1 µM arsenite. (europa.eu)

Recently, As has been recognized as an endocrine disruptor because it alters steroid and thyroid hormone receptor-mediated gene regulation at low and environmentally-relevant levels in cell culture and whole-animal models. (biomedcentral.com)
The present investigation describes a previously unknown mechanism showing that an imbalance of pro- and anti-inflammatory T cells is involved in the pathogenesis of arsenicosis and that a GBE exerts effects on arsenicosis through regulation of the pro- and anti-inflammatory T cell balance. (ijbs.com)
PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism. (pka-inhibitor.com)

By heterodimerizing with the tiny Maf proteins as coactivator, jointly, they bind towards the ARE and transactivate subunit by itself was sufficient to improve GSH amounts in the transfected cells [29]. (healthanddietblog.info)

Sodium arsenite treatment decreased circulating levels of estradiol in a dose and time-dependent manner, along with decrease in the levels of both LH and FSH. (biomedcentral.com)
Since levels of MRP2 are already high in the hepatocytes, this may clarify why only marginal raises of MRP2 was seen in the livers of CDDP-treated animals [24]. (healthanddietblog.info)
It was thus concluded that the changes due to the assayed doses of Pb in the levels of antibodies cannot be explained on the basis of only one single action mechanism of the metal, but as the result of a conjunction of effects over different immunocompetent cell subpopulations. (scielo.org.ar)
Patients with arsenicosis exhibited higher levels of Th17 cells, Th17-related cytokines (IL-17A and IL-6), and the transcription factor RORγt. (ijbs.com)
There were lower levels of Treg cells, a Treg-related cytokine (IL-10), and the transcription factor Foxp3 as compared with controls. (ijbs.com)
There was a positive correlation between the levels of Th17 cells and IL-17A and the levels of arsenic in hair. (ijbs.com)
Administration of GBE to patient upregulated the numbers of Treg cells and the level of IL-10 and downregulated the numbers of Th17 cells and the levels of cytokines associated with Th17 cells. (ijbs.com)

Stress-induced changes of gene expression are crucial for survival of eukaryotic cells. (prolekarniky.cz)
Identification of PARD3 signature on PARD3 deficient H157 cell line, reconstituting the expression of PARD3 gene, with a wt and a mutant form. (nih.gov)
Here, we hypothesized that specific histone residue(s) might be involved in facilitating gene expression such that cells mount a response to rapamycin. (researchsquare.com)

Effects of sodium ferulate on preventing steroid-induced femoral head osteonecrosis in rabbits[J]. Journal of Zhejiang University Science B, 2013, 14(5): 426-437. (zju.edu.cn)

Different animal models of experimental acute pancreatitis induced by caerulein, choline deficient ethionine supplemented (CDE) diet, or sodium taurocholate have been developed. (pancreapedia.org)

Yet the specific contribution of Tcf-1 to early T-cell development and the signals inducing it in these cells remain unclear. (refine.bio)

A single dose of 500 mg/100 g injected i.p. resulted in 70-80% of pancreatic acinar cell necrosis within 3 days. (pancreapedia.org)

However, overstimulation of ERK1/2 by PHTPP alone made it difficult to determine if ERβ is involved in cadmium and arsenite stimulated ERK1/2 activation. (bellarmine.edu)
2011)*. To allow easy assessment of the activation status of these biomarker genes, green fluorescent (GFP) mES reporter cell lines were generated. (europa.eu)

Under the test conditions, sodium arsenite is not considered as mutagenic to E. coli or to Chinese hamster cells. (europa.eu)

However, the ability of HPV-infected cells to resist apoptotic signals renders such therapies ineffective. (mdpi.com)

Mizunuma et al (18) were first to report that intra-peritoneal (i.p.) administration of excessive doses of L-arginine (500 mg/100 g body weight) in rats selectively damage pancreatic acinar cells without any morphological change in islets of Langerhans or other organs. (pancreapedia.org)

Multiple muscle wasting-related transcription factors are acetylated in dexamethasone-treated muscle cells. (per-olofhasselgren.com)
The numbers of Th17 and Treg cells, as well as related transcription factors and serum cytokines, were determined at the beginning and end of the study. (ijbs.com)

Overactive Notch signaling as been observed in numerous cancers and has been extensively studied in the context of T-cell acute lymphoblastic leukemia (T-ALL) where more than 50% of pateints harbour mutant NOTCH1. (refine.bio)
Similar to the H2B R95A mutant, cells devoid of Ste5 are also resistant to rapamycin. (researchsquare.com)
Indeed, it has been shown that a histone mutant H3 K56A causes yeast cells to display sensitivity to rapamycin, however, this mutation also sensitizes cells to a variety of DNA damaging agents, suggesting that the H3 K56A mutation has a broader role rather than a specific function towards rapamycin stress [22, 23]. (researchsquare.com)

In this study, the production of antibodies was assessed against sheep red blood cells (SRBC) in the anuran Bufo arenarum after six weekly injections of sublethal doses of lead (50 mg.kg -1 , as lead acetate). (scielo.org.ar)

A non-malignant human bronchial epithelial cell line, Beas-2B cells were exposed to 100 nM sodium arsenite for 24 weeks. (louisville.edu)

Anatomy5

Diseases1

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes11

Information Science2

Health Care1

Induces3

Endothelial cells3

Arsenate5

Induce3

Exposure6

Upregulation2

Apoptosis11

Assay9

Arsenic trioxide4

Phosphorylation2

Signaling pathway5

Mechanisms7

Arsenates1

Concentrations4

Viability2

Proliferation2

Tissue3

Lung2

Responses1

Differentiation4

Analyses2

Atherosclerosis2

Epithelial cells1

Induction2

Biol1

Vitro1

Bacterial1

MRNA4

Vascular1

Protein expression levels1

Oxidative stress1

Assess2

Kinase4

Transcriptional2

Arrest4

Roles1

Activate1

Results2

Neuropharmacology1

Found4

A5491

Mutations1

Regulation3

Proteins1

Levels7

Expression3

Effects1

Deficient1

Unclear1

Necrosis1

Activation2

Conditions1

Apoptotic1

Selectively1

Transcription factors2

Mutant3

Study1

Human1