AutophagyApoptosisCell ProliferationApoptosis Regulatory ProteinsCaspasesCaspase 3Cell Line, TumorProto-Oncogene Proteins c-bcl-2Signal TransductionInhibitor of Apoptosis ProteinsCell SurvivalCells, CulturedDNA FragmentationIn Situ Nick-End Labelingbcl-2-Associated X ProteinX-Linked Inhibitor of Apoptosis ProteinMicrotubule-Associated ProteinsMitochondriaCell LineCell CycleTumor Cells, CulturedTumor Suppressor Protein p53Enzyme ActivationBlotting, WesternApoptosis Inducing FactorPhagosomesCASP8 and FADD-Like Apoptosis Regulating ProteinCell DivisionCaspase InhibitorsCaspase 9RNA, Small InterferingCaspase 8Flow CytometryFas Ligand ProteinAntineoplastic AgentsCytochromes cbcl-X ProteinProto-Oncogene ProteinsPhosphorylationMice, Inbred C57BLTransfectionCell DeathDown-RegulationReactive Oxygen SpeciesEnzyme InhibitorsRNA, MessengerAnnexin A5Dose-Response Relationship, DrugCell DifferentiationCysteine Proteinase InhibitorsModels, BiologicalAmino Acid Chloromethyl KetonesMice, KnockoutProto-Oncogene Proteins c-aktRNA InterferenceUp-RegulationReverse Transcriptase Polymerase Chain ReactionImmunohistochemistryTime FactorsMembrane ProteinsTOR Serine-Threonine KinasesPoly(ADP-ribose) PolymerasesGene Expression Regulation, NeoplasticGene Expression RegulationProtein-Serine-Threonine KinasesFibroblastsMembrane Potential, MitochondrialJurkat CellsEpithelial CellsLysosomesNecrosisHL-60 CellsMice, TransgenicTumor Necrosis Factor-alphaTNF-Related Apoptosis-Inducing LigandCaspase 7HeLa CellsGene ExpressionCarrier ProteinsNF-kappa BMice, NudeMutationMembrane GlycoproteinsGene Knockdown TechniquesDNA DamageT-LymphocytesUbiquitin-Activating EnzymesGenes, bcl-2Phosphatidylinositol 3-KinasesOxidative StressTranscription FactorsDrug SynergismNeoplasm Proteinsbcl-2 Homologous Antagonist-Killer ProteinProteinsDNA-Binding ProteinsIntracellular Signaling Peptides and ProteinsDisease Models, AnimalRats, Sprague-DawleyMolecular Sequence Data