• Cell Physiological Phenomena" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • This graph shows the total number of publications written about "Cell Physiological Phenomena" by people in this website by year, and whether "Cell Physiological Phenomena" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Cell Physiological Phenomena" by people in Profiles. (childrensmercy.org)
  • Our research is integrative and translational and covers a variety of disciplines ranging from stem cell biology to whole body system physiology. (kcl.ac.uk)
  • The PlanHab wash-out period corresponded to a profound life-style change (i.e., reintroduction of exercise) that resulted in stepwise amelioration of the negative physiological symptoms, indicating that exercise apparently prevented the crosstalk between the microbial physiology, mucin degradation and proinflammatory immune activities in the host. (frontiersin.org)
  • Modern technological advances allow for the precise opto- or chemogenetic manipulation of different SCN cell types, based on characteristics such as their neuropeptide content, to establish the roles they play in circadian control of physiology. (manchester.ac.uk)
  • This thesis will focus on the role of SCN VIP cells, a principle neuropeptide population within the SCN, and their involvement in the control of physiology. (manchester.ac.uk)
  • Physiological shear stress enhances differentiation and mucus-formation of intestinal epithelial cells in vitro. (authorea.com)
  • We demonstrated the impact of culture conditions on the differentiation of HT29-MTX cells, revealing outstanding in vivo like reorganization of cells and the production of thick adherent mucus networks when cultured under physiological shear stress using our newly designed culture chamber. (authorea.com)
  • Scholars@Duke publication: Differentiation and characterization of human iPSC-derived vascular endothelial cells under physiological shear stress. (duke.edu)
  • We also describe a parallel-plate flow chamber system to study EC behavior under physiological shear stress. (duke.edu)
  • 37. What is the physiological basis for Multiple Sclerosis? (fsu.edu)
  • A new discovery in B cell research may lead to better treatments for people living with multiple sclerosis (MS). (healthline.com)
  • Elisabeth Mari, PhD, the director of biomedical research for the National Multiple Sclerosis Society, emphasizes the importance of learning more about the role of B cells and disease progression. (healthline.com)
  • Inactivity and hypoxia resulted in a significant increase in the genus Bacteroides in HBR, in genes coding for proteins involved in iron acquisition and metabolism, cell wall, capsule, virulence, defense and mucin degradation, such as beta-galactosidase (EC3.2.1.23), α-L-fucosidase (EC3.2.1.51), Sialidase (EC3.2.1.18), and α-N-acetylglucosaminidase (EC3.2.1.50). (frontiersin.org)
  • The fact that the genus Bacteroides and proteins involved in iron acquisition and metabolism, cell wall, capsule, virulence and mucin degradation were enriched at the end of HBR suggest that both constipation and EC decreased intestinal metal availability leading to modified expression of co-regulated genes in Bacteroides genomes. (frontiersin.org)
  • This technique requires that whole proteins or selected peptide antigens are added to blood cells, allowing the simultaneous analysis of both major histocompatibility complex class I and II restricted T-cell responses ( 7 ). (cdc.gov)
  • 1 - 3 For example, in vivo light/dark transitions trigger RPE physiological changes that homeostatically maintain the chemical composition and volume of the extracellular spaces separating the apical membrane/photoreceptor and basolateral/Bruch membrane interfaces. (arvojournals.org)
  • We found that Homer3, the predominant isoform in Purkinje cells, is phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) both in vitro and in vivo . (jneurosci.org)
  • Induction of GSH-related genes xCT and GCLM were oxygen and Bach1-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2-Keap1 defense pathway in cells adapted to physiological O2 levels encountered in vivo. (ox.ac.uk)
  • Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopamine neurons in vitro and in vivo, and intracranial delivery of GDNF has been tested in six clinical trials for treating PD. (lu.se)
  • Induced pluripotent stem cells (iPSCs) offer a potentially unlimited source to generate endothelial cells (ECs) for numerous applications. (duke.edu)
  • Here, we describe a 7-day protocol to differentiate up to 55 million vascular endothelial cells (viECs) from 3.5 million human iPSCs using small molecules to regulate specific transcription factors. (duke.edu)
  • Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels. (ox.ac.uk)
  • Researchers have been looking into the neurological effects of too many B cells in a person's body. (healthline.com)
  • Too many B cells could lead to neurological damage. (healthline.com)
  • 26. What physiological processes are in common for all neuron types? (fsu.edu)
  • Pregnancy-related maternal physiological adaptations and fetal chemical exposure. (bvsalud.org)
  • The lack of associations could be related to either physiological adaptations or ceiling effects in this sample. (cdc.gov)
  • Genetic, physiological and biochemical characterization of Bacillussp. (biomedcentral.com)
  • Genetic, physiological and biochemical characterization of Bacillus sp. (biomedcentral.com)
  • The present study was conducted aiming to evaluate the possible effect of zinc supplementation as potent antioxidant in counteracting some of the physiological and biochemical alterations induced by subchronic administration of deltamethrin, a synthetic pyrethroid. (scialert.net)
  • Many physiological and biochemical alteration have been induced by deltamethrin intoxication. (scialert.net)
  • Biochemical and physiological alterations following short term exposere to fluvalinate-a synthetic pyrethroid. (scialert.net)
  • Methods in cell biology , 100 (C), 219-231. (elsevierpure.com)
  • Trapani, JG & Nicolson, T 2010, ' Physiological recordings from zebrafish lateral-line hair cells and afferent neurons ', Methods in cell biology , vol. 100, no. (elsevierpure.com)
  • While the molecular biology of the two viruses has been characterized in great detail, the absence of robust cell culture models for HBV and/or HDV infection has limited the investigation of virus-host interactions. (mdpi.com)
  • Mari told Healthline that overall interest in B cell biology has increased, mainly because of ocrezimulab. (healthline.com)
  • Our focus is on further understanding (via cryoEM, with Prof Alex Cameron) the structural biology of how CO 2 causes conformational change in these connexins and elucidating further physiological functions of connexin mediated CO 2- signalling such as hypercapnic arousal reflexes (with Prof Mark Wall). (warwick.ac.uk)
  • Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
  • Mechanisms whereby extracellular adenosine 3',5'-monophosphate inhibits phosphate transport in cultured opossum kidney cells and in rat kidney. (jci.org)
  • Name physiological mechanisms where transport is operational? (fsu.edu)
  • The study gives us more insight into the roles and mechanisms of not only B cells, but other cells in the body that might be playing a role in shaping the B cells to be more destructive," she said. (healthline.com)
  • Understanding cells' mechanisms helps scientists to understand diseases. (healthline.com)
  • Understanding the mechanisms involved in guiding at least under homeostatic or physiological conditions. (lu.se)
  • The purpose of this narrative review is to give an overview of major pregnancy -related physiological changes, including placental function and impacts of pregnancy complications , to summarize existing studies assessing chemical exposure in human fetal organs, and to discuss possible interactions between physiological changes and exposures. (bvsalud.org)
  • Mihaylova, M. M. & Shaw, R. J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. (nature.com)
  • Kottmeier, D. M. , Terbrüggen, A. , Wolf-Gladrow, D. and Thoms, S. (2020): Diel variations in cell division and biomass production of Emiliania huxleyi -- Consequences for the calculation of physiological cell parameters , Limnol. (awi.de)
  • The comparison of 90 morphological, physiological, and behavioral parameters revealed elevated body weight and hematocrit as the only major difference of ES mice, which exhibited an otherwise normal phenotype. (mdc-berlin.de)
  • Interferon (IFN)-γ synthesis by T cells after an in vitro. (cdc.gov)
  • Processed by a variety of proteases linked to inflammation, it activates the G-protein coupled receptor chemokine-like receptor 1 (CMKLR1) and induces chemotaxis in natural killer cells, macrophages, and immature dendritic cells. (nih.gov)
  • Studies have demonstrated that severe oligohydramnios decreased lung cell size, alters cell shape and may also negatively affect Type I cell differentiation which ultimately induces pulmonary hypoplasia. (medscape.com)
  • Pregnancy induces a range of significant physiological changes in women that may affect chemical metabolism and responses. (bvsalud.org)
  • Differentiation of a confluent monolayer of human mucus-producing epithelial HT29-MTX cells was monitored under dynamic and static culture conditions. (authorea.com)
  • Several growth factors such as fibroblast growth factor (FGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF), promote cell proliferation and differentiation. (medscape.com)
  • Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
  • A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
  • Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
  • Scientists say B cells can be beneficial, but too many can bring on MS symptoms. (healthline.com)
  • The results indicated that people with higher amounts of these suppressor cells showed milder MS symptoms. (healthline.com)
  • Those with lower numbers of the cells experienced worse symptoms. (healthline.com)
  • We show that graded differences in these and other physiological properties across the MSO neuron population enable the MSO to duplex the encoding of ITD information in both fast, submillisecond time-varying signals as well as in slower envelopes. (jneurosci.org)
  • In this report, their interactions with algae were investigated using two strains of Chlamydomonas reinhardtii, a wild type having cell wall and a cell wall-deficient mutant. (elsevierpure.com)
  • Culture aggregation was found only for wild type cells, probably because of interactions between mannose and cell wall glycoproteins. (elsevierpure.com)
  • We conclude that nanoparticles' deteriorating effect in algae is caused by interactions with the cell wall, causing an aggregation of cell culture, and not by nanoparticle penetration inside the cytoplasm. (elsevierpure.com)
  • This study reports new information about the ways that B cells and their interactions with other cells contribute to damage in the central nervous system in a mouse model. (healthline.com)
  • Previous studies thus appear to suggest that light responses alone do not contain sufficient information for reliable RGC classification unless a careful stimulus ensemble is designed to evoke optimal responses, in particular for specialized RGCs such as DS cells. (frontiersin.org)
  • Yet, if different RGC types have distinct cellular physiological properties, light responses, and systematic differences in their presynaptic input neurons, it may be possible to use a sufficiently rich stimulus to evoke responses to unmask their distinctive functional features. (frontiersin.org)
  • Understanding physiological responses to aviation and space flight and their medical implications. (kcl.ac.uk)
  • By monitoring T-cell responses by flow cytometry, we observed a recall response after recent vaccination against smallpox. (cdc.gov)
  • Moreover, antigen-specific T-cell responses could be detected in exposed, but uninfected persons, as shown in those with HIV infection ( 3 ). (cdc.gov)
  • Flow cytometric analysis of T-cell responses to smallpox antigens after recent smallpox vaccination and in long-term vaccinated or not vaccinated persons. (cdc.gov)
  • Oxygen levels in cell research: how important is this? (nikon.com)
  • Prof. Giovanni E. Mann will discuss the control of environmental factors including ambient oxygen, CO 2 , pH, and the composition of cell culture media and why this is critical to ensure physiologically relevant cellular function. (nikon.com)
  • The effects of physiological oxygen tension on Nuclear Factor-E2-Related Factor 2 (Nrf2)-regulated redox signaling remain poorly understood. (ox.ac.uk)
  • The purpose of this study is to examine associations between objectively measured workplace sedentary behavior and physiological markers of health. (cdc.gov)
  • In a sample that is predominantly sedentary, at risk for cardiovascular disease, and prediabetic, there are no significant associations between workplace sedentary behavior and physiological markers. (cdc.gov)
  • Treatment with the anti-AREG antibody prevented resolution of DE exposure-induced airway influx of total cells, neutrophils, and macrophages and increased levels of TNF-a, IL-6, and CXCL1. (cdc.gov)
  • Uranium Toxicity: What Are the Physiological Effects of Uranium Exposure? (cdc.gov)
  • show this method can be used for examining other physiological conditions, such as exposure to nitric oxide and osmotic pressure. (osti.gov)
  • There is probably no single one chemical exposure responsible for these illnesses, but more likely a mixed exposure of chemical classes such as particulate matter and oxygenated organic species (oxidized volatile organic compounds that are likely biologically reactive and potentially cause cell damage and increase susceptibility to disease). (cdc.gov)
  • Cell division of the coccolithophore Emiliania huxleyi and other phytoplankton typically becomes entrained to diel light/dark cycles under laboratory conditions, with division occurring primarily during dark phases and production occurring during light phases. (awi.de)
  • Additionally, the median mucus thickness was significantly increased under dynamic conditions compared to static culture (41±14 vs. 29±14 µm) with a simultaneous drastic reduction of culture time from three to two weeks for sufficient maturation into goblet-like cells. (authorea.com)
  • The physiological conditions experienced by a microbial community can thus be inferred using meta-transcriptomic sequencing by comparing transcription levels of specifically chosen genes. (osti.gov)
  • Nevertheless, together with benchmarking analyses, we show here that the diametric ratio approach can be applied for evaluating the physiological conditions experienced by microbes in situ. (osti.gov)
  • Attachment of DNA to the nucleoskeleton of HeLa cells examined using physiological conditions. (ox.ac.uk)
  • Therefore we have re-investigated attachments of chromatin to the skeleton using physiological conditions. (ox.ac.uk)
  • Zinc chloride was a competitive antagonist of the action of Ca2+ in histamine secretion induced by anti-IgE with a dissociation constant (Kd) of about 10(-5) M in both the basophil and mast cell systems. (nih.gov)
  • Mol Cell Endocrinol;578: 112064, 2023 Dec 01. (bvsalud.org)
  • At the opening AACR 2023 plenary session, Ralph DeNardo celebrated the successes of the current, mostly T-cell-based approaches, but also encouraged his colleagues to think more broadly about the antitumor immunity. (bioworld.com)
  • The lateral-line system in zebrafish serves as an ideal platform to examine encoding of stimuli by sensory hair cells. (elsevierpure.com)
  • Here, we describe methods for recording hair-cell microphonics and activity of afferent neurons using intact zebrafish larvae. (elsevierpure.com)
  • When combined, these techniques make it possible to probe the function of the lateral-line sensory system in an intact zebrafish using controlled, repeatable, physiological stimuli. (elsevierpure.com)
  • We have previously shown that physiological concentrations of zinc (congruent to 7 X 10(-6) M) inhibit the release of histamine from human basophil leukocytes (Marone et al. (nih.gov)
  • Thus physiological concentrations of zinc inhibit the release of histamine from human basophils and lung mast cells, presumably by blocking Ca2+ uptake induced by anti-IgE activation. (nih.gov)
  • Deviations from exponential growth furthermore imply that increases in cell and biomass concentrations cannot be expressed by the daily growth rate μ_{24 h} (typically determined from daily increments in cell concentrations). (awi.de)
  • To account for this, we here describe short-term changes in cell and biomass concentrations of fastdividing, dilute-batch cultures of E. huxleyi grown under a diel light/dark cycle using linear regression. (awi.de)
  • In physiological concentrations, androgens have no specific effects in women. (cdc.gov)
  • As a parameter-free method, our approach is broadly applicable for cellular physiological classification in all sensory modalities. (frontiersin.org)
  • Among the 21 sensory cells of each of these hairs there are two mechanosensitive ones, responding to the deflection of the hair shaft (Harris and Mill 1973, 1977) . (scholarpedia.org)
  • The RPE is a monolayer of cells between the neural retina and choroidal blood supply, and is critically important for photoreceptor function. (arvojournals.org)
  • Our research is focused on fundamental questions regarding human physiological function and adaptation in health and disease. (kcl.ac.uk)
  • In addition, there are cardiopulmonary and vascular changes, including a significant decrease in red blood cell mass, that affect skeletal muscle function. (wikipedia.org)
  • Together, these findings suggested that Homer3 in Purkinje cells might function as a reversible coupler regulated by CaMKII phosphorylation and that the phosphorylation is capable of regulating the postsynaptic molecular architecture in response to synaptic activity. (jneurosci.org)
  • Here, the current understanding of chemerin processing, signaling and physiological function has been summarized, focusing on the regulation of its activity, its different receptors and its controversially discussed role in diseases. (nih.gov)
  • decrementing, what is their physiological function? (fsu.edu)
  • We are also exploiting evolution of connexins to devise chimaeric modified connexin subunits that can coassemble with endogenously expressed connexins to remove CO 2 sensitivity very selectively allowing us to further probe physiological function. (warwick.ac.uk)
  • Retinal ganglion cells, the sole output neurons of the retina, exhibit surprising diversity. (frontiersin.org)
  • Traditionally, all models of sound localization have assumed that MSO neurons represent a single population of cells with specialized and homogeneous intrinsic and synaptic properties that enable the detection of synaptic coincidence on a timescale of tens to hundreds of microseconds. (jneurosci.org)
  • Here, using patch-clamp recordings from large populations of anatomically labeled neurons in brainstem slices from male and female Mongolian gerbils ( Meriones unguiculatu s), we show that MSO neurons are far more physiologically diverse than previously appreciated, with properties that depend regionally on cell position along the topographic map of frequency. (jneurosci.org)
  • SIGNIFICANCE STATEMENT Neurons in the medial superior olive (MSO) encode sound localization cues by detecting microsecond differences in the arrival times of inputs from the left and right ears, and it has been assumed that this computation is made possible by highly stereotyped structural and physiological specializations. (jneurosci.org)
  • Another readout of the hair-cell activity is obtained by recording action currents from single afferent neurons in response to water-jet stimulation of innervated hair cells. (elsevierpure.com)
  • Initially I assessed the electrophysiological impact of optogenetic SCN VIP cell activation on downstream neurons to establish what, if any, influence they exert over downstream neuronal populations. (manchester.ac.uk)
  • Principally, when SCN VIP neurons are inhibited during their peak activity phase, there was an increase in circulating corticosterone, implicating SCN VIP cells in the suppression of corticosterone prior to the daily rise. (manchester.ac.uk)
  • This thesis adds to the growing body of work positing SCN VIP neurons as not only input mediators within the SCN network, but also a key transmitter of daily timing information to key physiological systems. (manchester.ac.uk)
  • Cirrhosis of the liver is associated with a ron-specific enolase (NSE) and it has been decreased health-related quality of life, shown to be located in neurons and neur- whether physically (especially at advanced oectodermal cells [10,11]. (who.int)
  • Para la elaboración de este artículo de revisión narrativa se consultaron las publicaciones disponibles a neutrófilos en el través de una búsqueda automatizada en las bases de datos de PubMed, Scopus y Embase. (bvsalud.org)
  • Dr. Thomas Korn, a professor of experimental neuroimmunology at the TUM Neurology Clinic in Germany and study co-author, explained that the broader perspective of the study is that "by exploiting the regulatory loop, we found the intrathecal B cell compartment, which might be a driver of chronic disease in MS and could be better targeted in therapeutic interventions. (healthline.com)
  • The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of "mast cell activation syndrome" (MCAS) grown significantly. (degruyter.com)
  • The appearance of a detectable antibody titer takes place a few days after the induction of a T-cell response ( 2 ). (cdc.gov)
  • These results indicate that luminal degradation of cAMP into adenosine, followed by cellular uptake of the nucleoside by tubular cells, is a key event which accounts for the phosphaturic effect of exogenous cAMP and for the part of the phosphaturic effect of PTH which is mediated by cAMP added to the tubular lumen under the influence of the hormone. (jci.org)
  • In these experiments we compared the effect of zinc chloride on the release of chemical mediators from human basophils and mast cells isolated from human lung. (nih.gov)
  • Preincubation (5 min, 37 degrees C) of human basophils and lung mast cells with zinc chloride (10(-6)-3 X 10(-5) M) caused dose-related inhibition of histamine and peptide leukotriene C4 (LTC4) release induced by anti-IgE. (nih.gov)
  • It results in a reduction in the number of lung cells, airways, and alveoli that results in impaired gas exchange. (medscape.com)
  • FGF signaling is thought to be essential in the formation of TTF-1 expressing cells and this is thought to occur even before the pseudoglandular stage of lung development. (medscape.com)
  • Accurate fluid pressure in the fetal lung is critical for its development, especially at the beginning of the saccular stage when alveolar epithelial type 1 (AT1) and type 2 (AT2) cells differentiate from the epithelial progenitors. (lu.se)
  • Adaptation of EC to 5% O2 had minimal effects on cell ultrastructure, viability, basal redox status or HIF1-α expression. (ox.ac.uk)
  • Among these, the citric acid cycle intermediate succinate stands out owing to its multiple roles in disparate pathways, its dramatic concentration changes and its selective cell release. (nature.com)
  • That is why drug development focuses on activating specific molecular signal pathways within cells. (sciencedaily.com)
  • This means we are understanding more about the pathways and the cells involved in MS and particularly with progression. (healthline.com)
  • In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)
  • On the morning of day seven of each supplementation condition, participants consumed one final serving of BLN or PLA and performed a 30-min cycling TT with concurrent assessment of several physiological variables and blood markers. (springer.com)
  • Sedentary work and physiological markers of health. (cdc.gov)
  • Students use an array of methods including computational modelling, cell culture, behavioral analysis, chemogenetics, optogenetics and human EEG in laboratory classes and during collaborative research with faculty. (oberlin.edu)
  • B cells provide a defense against pathogens in our bodies. (healthline.com)
  • This ability of the B cells to produce antigens through the T cells could lead to progression," Mari told Healthline. (healthline.com)
  • We evaluate our approach using synthetic spike trains, and demonstrate that major known cell types are identified in high-density recording sessions from the mouse retina with around 1,000 retinal ganglion cells. (frontiersin.org)
  • We further demonstrate that ES mouse mutants can be produced from mutant hybrid ES cells and analyzed within a period of only 4 months. (mdc-berlin.de)
  • The fluorochrome-labeled cells are analyzed by flow cytometry, which categorizes individual cells according to size, granularity, fluorochrome, and fluorochrome intensity. (cdc.gov)
  • Subsequent literature regarding this newly recognized (but of course not truly new) "mast cell activation syndrome" (MCAS) included case reports as well as formal studies (mostly relatively small scale), reviews, and various proposals for formal diagnostic criteria. (degruyter.com)
  • PBMC were cultured in complete Roswell Park Memorial Institute 1640 medium, 10% v/v heat-inactivated fetal calf serum, 2 mM L-glutamine, and 10 U/mL penicillin/streptomycin at a concentration of 10 6 cells/mL. (cdc.gov)
  • The mechanism of phosphaturia induced by cAMP infusion and the physiological role of extracellular cAMP in modulation of renal phosphate transport were examined. (jci.org)
  • What is the actual physiological mechanism? (cdc.gov)
  • Stem Cells and Development (2013), Bd. (uni-tuebingen.de)
  • ES cell-tetraploid (ES) mice are completely derived from embryonic stem cells and can be obtained at high efficiency upon injection of hybrid ES cells into tetraploid blastocysts. (mdc-berlin.de)
  • The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)
  • To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)
  • Five 10-fold dilutions in physiological saline of each virus grown in Madin-Darby Canine Kidney (MDCK) cells were tested with all of the RIDTs in duplicate. (cdc.gov)
  • Furthermore, both robust phosphorylation of Homer3 and its dissociation from metabotropic glutamate receptor 1α (mGluR1α) were triggered by depolarization in primary cultured Purkinje cells, and these events were inhibited by CaMKII inhibitor. (jneurosci.org)
  • In Purkinje cells, Homer3 is distributed throughout the dendrites, axons, and soma, but the most remarkable accumulation of Homer3 was observed in dendritic spines. (jneurosci.org)
  • In this study, we revealed that Homer3 was phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) in Purkinje cells, and the phosphorylation reduces the affinity for Homer target molecules, resulting in change of the solubility. (jneurosci.org)
  • These results suggest that the phosphorylation may regulate postsynaptic molecular architecture and Ca 2+ signaling of Purkinje cells in response to synaptic activity. (jneurosci.org)
  • Second, these antibodies impair the induction of synaptic plasticity, rebound potentiation, and LTD, on Purkinje cells, resulting in loss of restoration and compensation of the distorted "internal models. (springer.com)
  • This paper adds another layer of understanding in the central nervous system as a result of B cells," Mari said. (healthline.com)
  • We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)
  • 35. Do all nerve cells have the same threshold and space constant? (fsu.edu)
  • In cultured opossum kidney cells, extracellular cAMP (10-1,000 microM) inhibited Na-dependent phosphate uptake in a time- and concentration-dependent manner. (jci.org)
  • Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. (mdpi.com)
  • Role of neutrophil extracellular la NETosis en las enfermedades infecciosas pulmonares. (bvsalud.org)
  • It is well established that the retina has multiple, functionally complementary populations of retinal ganglion cells (RGCs), which together transmit visual information to various central visual areas ( Roska and Werblin, 2001 ). (frontiersin.org)
  • When we look at untreated MS patients we see indication that there is some relationship between these two populations of cells and how they are interacting," she said. (healthline.com)
  • The retinal ganglion cell is situated in the inner retina and its axons, composing the retinal nerve fiber layer (RNFL), leave the eye to form the optic nerve. (avhandlingar.se)