Cells therapy allogeneic stem cell transplantation. Medical search. Frequent questions

Allogeneic SCT is an effective and accepted therapeutic option for many patients with hematologic malignancies that are incurable with standard chemotherapy. (medscape.com)
The patient experienced relapse 2 years after receiving first-line therapies, which included chemotherapy, surgical resection, irradiation, and autologous peripheral SCT. (biomedcentral.com)
Although combination chemotherapy regimens including the nucleoside analogue fludarabine were once the most commonly used first-line therapy in CLL, non-chemotherapy regimens (eg, with Bruton tyrosine kinase [BTK] inhibitors) are currently preferred in most cases. (medscape.com)
Diffuse large B-cell lymphoma (DLBCL) patients must have received at least two prior chemotherapy-containing regimens at least one of which must have contained doxorubicin and a monoclonal antibody. (nih.gov)
Chemotherapy drugs kill fast-growing cells throughout the body, including both cancer cells and normal, healthy cells. (lls.org)
Targeted therapy may be used alone or in combination with chemotherapy. (lls.org)
If the initial treatment does not induce a remission, induction therapy can be repeated, either with the same drugs or with a new chemotherapy regimen. (lls.org)
Patients with favorable risk factors are often given intensive chemotherapy with high-dose cytarabine and other drugs for their consolidation therapy. (lls.org)
Notable Labs uses a flow cytometric-based assay to test a panel of FDA-approved chemotherapy and targeted agents-singly and in combinations using a custom robotic platform-to determine anti-cancer effect against individual patient's tumor cells. (notablelabs.com)
KENILWORTH, N.J.--(BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that it will stop the Phase 3 KEYLYNK-010 trial investigating KEYTRUDA, Merck's anti-PD-1 therapy, in combination with LYNPARZA, a PARP inhibitor, for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) who progressed after treatment with chemotherapy and either abiraterone acetate or enzalutamide. (merck.com)
Oral infections: Suppression of white cell counts from chemotherapy increases the risk of developing viral, bacterial, and fungal infections in the oral cavity. (dana-farber.org)
Outcomes of allogeneic or autologous stem cell transplantation followed by maintenance chemotherapy in adult patient with B-ALL in CR1 with no detectable minimal residual disease. (stembook.org)
Giving chemotherapy before a stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. (uchicagomedicine.org)
Giving more than one drug (combination chemotherapy) and giving dasatinib together with chemotherapy may kill more cancer cells. (uchicagomedicine.org)
I. Estimate the disease-free survival (DFS) and overall survival (OS) profiles in newly diagnosed patients 18 years or older who have Philadelphia chromosome positive (Ph+) (BCR/(v-abl Abelson murine leukemia viral oncogene homolog [ABL]+) acute lymphoblastic leukemia (ALL) receiving sequential dasatinib followed by allogeneic or autologous hematopoietic cell transplant (HCT) or chemotherapy followed by dasatinib maintenance. (uchicagomedicine.org)
Study the safety and efficacy of dasatinib maintenance administered after allogeneic or autologous HCT or chemotherapy. (uchicagomedicine.org)

Recipients of allogeneic HSCT are also at risk for developing graft-versus-host disease in the mouth. (dana-farber.org)
acute or chronic graft-versus-host disease (when transplanted cells attack the body) in people aged 12 and older who have had a transplantation and for whom corticosteroids or other systemic therapies (treatments given by mouth or injection) did not work well enough. (europa.eu)
JAKs are also involved in the development and activation of blood cells that play a role in graft-versus-host disease. (europa.eu)
The first study involved 309 patients with acute graft-versus-host disease after allogeneic stem cell transplantation (using stem cells from a donor) in whom corticosteroid therapy did not work. (europa.eu)
The second study involved 329 patients with chronic graft-versus-host disease after allogeneic stem cell transplantation in whom corticosteroid therapy did not work. (europa.eu)

4, 5, 2] Allogeneic stem cell transplantation is the only known curative therapy for CLL. (medscape.com)
Allogeneic stem cell transplantation is currently the only curative treatment option for myelodysplastic syndromes (MDS). (nature.com)
Background: Allogeneic hematopoietic stem cell transplantation (alloHCT) is potentially curative but with known negative effects on quality of life. (cdc.gov)
The over-arching goal of my research career has been to develop and expand curative therapies for hemoglobin disorders in particular and non-malignant hematopoietic disorders more broadly. (ucsf.edu)
I have focused on genome editing approaches most recently, which rely upon modification of autologous hematopoietic cells to elicit a curative effect. (ucsf.edu)
Treatment is often supportive, but Janus kinase 2 (JAK2) inhibitors, such as ruxolitinib , fedratinib , or pacritnib, may decrease symptoms and stem cell transplantation may be curative. (msdmanuals.com)

A recent report of a patient with relapsed ovarian cancer achieving disease regression following a myeloablative allogeneic SCT potentially identified this malignancy as being susceptible to GVT effects as well. (medscape.com)
Because normal CD5+ B cells are present in the mantle zone of lymphoid follicles, B-cell CLL is most likely a malignancy of a mantle zone-based subpopulation of anergic self-reactive cells devoted to the production of polyreactive natural autoantibodies. (medscape.com)

I have a long track record of experience in cellular therapies for pediatric acquired and hereditary conditions and in bone marrow transplantation. (ucsf.edu)
Enrollment Lessons from a Biological Assignment Study of Marrow Transplantation versus Standard Care for Adolescents and Young Adults with Sickle Cell Disease: Considerations for Future Gene and Cellular Therapy Trials. (ucsf.edu)
Comparable survival outcomes with haploidentical stem cell transplantation and unrelated bone marrow transplantation. (cdc.gov)
Bone marrow transplantation 2022 9 57 (12): 1781-1787. (cdc.gov)

Transplant Cell Ther. (ucsf.edu)

Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)
Lovo-cel gene therapy for sickle cell disease: Treatment process evolution and outcomes in the initial groups of the HGB-206 study. (ucsf.edu)
Outcomes following hematopoietic stem cell transplantation for higher risk childhood-onset cerebral adrenoleukodystrophy are variable. (ajnr.org)
Scores were generated for 64 evaluable patients and compared with CSF chitotriosidase levels, a known inflammatory marker correlating with outcomes following transplantation. (ajnr.org)
Primary graft failure following allogeneic hematopoietic stem cell transplantation: risk factors, treatment and outcomes. (stembook.org)

Through this combined translational and clinical strategy, Dr. Barrett's group is working toward optimizing the tremendous potential that stem cell transplantation holds in curing leukemia and other serious blood and bone marrow disorders. (nih.gov)
Clear cluster of differentiation 19 (CD19) expression must be uniformly detected on 75% or more of malignant cells from either bone marrow or a leukemia or lymphoma mass by flow cytometry or immunohistochemistry. (nih.gov)
Even when a complete remission is achieved, some leukemia cells that cannot be seen with a microscope may still remain in the bone marrow. (lls.org)
Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
2. To assess the clinical response of solid tumors to the bone or metastatic to the bone to therapy with infusional CylcoSam? (rwjbh.org)
9. A stem cell product collected either by peripheral stem cell mobilization or bone marrow harvest prior to the infusion of CycloSam® must be available, prior to trial entry. (rwjbh.org)
Patients with cancer that has spread to the bones treated with antiresorptive (bone-strengthening) therapies are at risk for developing jaw osteonecrosis. (dana-farber.org)
Following certain cancer therapies, dental infections, and in particular dental extractions, can result in jaw bone complications. (dana-farber.org)
Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, splenomegaly, and anemia with nucleated and teardrop-shaped red blood cells. (msdmanuals.com)
Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrow stem cells, which can manifest as an increased number of platelets, red blood cells (RBCs), or white blood cells (WBCs). (msdmanuals.com)
Primary myelofibrosis results from neoplastic transformation of a multipotent bone marrow stem cell. (msdmanuals.com)
These primary myelofibrosis progeny cells stimulate bone marrow fibroblasts (which are not part of the neoplastic transformation) to secrete excessive collagen. (msdmanuals.com)
Myelofibrosis is a disease in which the bone marrow becomes very dense and rigid and produces abnormal, immature blood cells. (europa.eu)

Ueno and colleagues [ 6 ] subsequently reported a small series of patients with metastatic breast cancer treated with a conventional myeloablative allogeneic transplant in which responses occurred in the context of acute skin GVHD and the withdrawal of immunosuppression , also implicating that these responses might have been the consequence of a GVT effect. (medscape.com)
Based on our findings, we suggest that 131 I-MIBG treatment with myeloablative allogeneic SCT should be considered as first-line therapy for high-risk neuroblastoma patients when possible. (biomedcentral.com)

Stem cell transplantation offers the chance of cure for leukemia patients through a unique graft-versus-leukemia GVL effect conferred by an immune reaction of the donor graft against the patient's leukemia. (nih.gov)
Dr Barrett's approach to improve SCT outcome is to generate in the laboratory immune cells from the donor that are capable of fighting viruses and leukemia without causing GVHD. (nih.gov)
Patients were recipients of autologous (patient's own cells) or allogeneic (donor cells) stem cell transplantations, which were administered in combination with CAR. (mdanderson.org)
Among 13 patients treated with donor CAR T cells after allogeneic stem cell transplantation, six remain in complete remission with a median follow-up of 7.5 months. (mdanderson.org)
Hematopoietic stem cell transplantation can be considered in young patients with chronic myelogenous leukemia in chronic phase if a human leukocyte antigen (HLA)-matched donor is available. (medscape.com)
Application prospect of low-dose porcine anti-thymocyte globulin in HLA-matched sibling donor transplantation. (stembook.org)

This is the basis for generating powerful leukemia-specific killer cells that could enhance the GVL response after transplant and eventually extend to the treatment of patients in remission from leukemia to prevent relapse of their disease. (nih.gov)
KENILWORTH, N.J.--(BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved KEYTRUDA, Merck's anti-PD-1 therapy, for the adjuvant treatment of patients with renal cell carcinoma (RCC) at intermediate-high or high risk of recurrence following nephrectomy, or following nephrectomy and resection of metastatic lesions. (merck.com)
Despite decades of research, limited adjuvant treatment options have been available for earlier-stage renal cell carcinoma patients who are often at risk for recurrence. (merck.com)
KEYTRUDA is now the first immunotherapy approved for the adjuvant treatment of certain patients with renal cell carcinoma. (merck.com)
Patients with CLL have a higher-than-normal white blood cell count, which is determined by complete blood count (CBC). (medscape.com)
The cells of origin in most patients with CLL are clonal B cells arrested in the B-cell differentiation pathway, intermediate between pre-B cells and mature B cells. (medscape.com)
However, CXCR4 mutation is not associated with splenomegaly, high platelet counts, or different response to therapy, questioning the relevance of CXCR4 in treating patients. (wikipedia.org)
Patients with the following malignancies are potentially eligible: any B-cell lymphoma, and chronic lymphocytic leukemia (CLL). (nih.gov)
Patients with indolent malignancies that have transformed to diffuse large B-cell lymphoma are eligible. (nih.gov)
About one third of MDS patients progress to AML, which is probably associated with expansion and evolution of subclones with certain mutations at the stem cell level 5 , 6 . (nature.com)
The genetic profiles of individual patients are heterogeneous and an individual patient's unique genetic makeup may impact their clinical phenotype, prognosis, and response to therapy. (nature.com)
Some patients may also receive targeted therapy. (lls.org)
AML patients whose leukemia cells have certain genetic mutations are assigned a specific risk status. (lls.org)
Most patients develop dangerously low blood cell counts and may become very ill, needing supportive (palliative) care with IV antibiotics and frequent blood transfusions during this time. (lls.org)
Testing for MRD can help doctors identify patients who may benefit from further treatment with intensified therapies, such as allogeneic stem cell transplantation. (lls.org)
Patients with high-risk AML, based on their prognostic factors, receive more aggressive therapy, such as allogeneic stem cell transplantation. (lls.org)
Not all patients can tolerate intensive therapies or even want them. (lls.org)
The risk of regretting transplantation was 17.5 percentage points (95% confidence interval, 5.5-29.7 percentage points) greater in patients who developed disease recurrence after HCT compared with patients who did not. (cdc.gov)
Conclusions: Among patients who underwent alloHCT and lived to 100 days, the majority did not report regretting their transplantation. (cdc.gov)
This study represents the first longitudinal evaluation of PBMCs from LDKT patients underlying mechanisms of tolerance at single cell resolution. (asn-online.org)
There remains a significant unmet need for patients diagnosed with advanced prostate cancer, who have a poor prognosis after not responding to initial therapy," said Dr. Roy Baynes, senior vice president and head of global clinical development, chief medical officer, Merck Research Laboratories. (merck.com)
Management ranges from watchful waiting and supportive care to targeted anti-C5 antibody therapy (e.g., eculizumab , ravulizumab ) for patients with significant clinical manifestations. (amboss.com)
Access to Chimeric Antigen Receptor T Cell Clinical Trials in Underrepresented Populations: A Multicenter Cohort Study of Pediatric and Young Adult Acute Lymphobastic Leukemia Patients. (ucsf.edu)
nevertheless, comprehensive data on red cell alloimmunization in such patients are limited. (haematologica.org)
This study evaluates the incidence and clinical impact of red cell alloimmunization in a large cohort of patients with myelodysplastic syndrome registered in the statewide South Australian-MDS registry. (haematologica.org)
Disease-modifying therapy was associated with a lower risk of alloimmunization while alloimmunization was significantly higher in patients with a revised International Prognostic Scoring System classification of Very Low, Low or Intermediate risk compared to those with a High or Very High risk ( P =0.03). (haematologica.org)
In conclusion, this study characterizes alloimmunization in a large cohort of patients with myelodysplastic syndrome and demonstrates a signficant increase in red cell transfusion requirements following alloimmunization, most probably due to development of additional alloantibodies and autoantibodies, resulting in subclinical/clinical hemolysis. (haematologica.org)
Study results of CD19-directed chimeric antigen receptor (CAR) therapy using the Sleeping Beauty non-viral transduction system to modify T cells have demonstrated further promise in patients with advanced hematologic malignancies. (mdanderson.org)
We are treating patients with advanced CD19 positive hematologic malignancies using CAR T cells in combination with conventional blood stem cell transplantation," said Kebriaei. (mdanderson.org)
We are also treating patients who had active disease but had not received blood stem cell transplantation. (mdanderson.org)
Five patients at high risk for relapse were treated with CAR T cells along with autologous stem cell transplant, and four of those patients remain in complete remission with a median follow-up of 12 months," she said. (mdanderson.org)
Kebriaei also reported that five out of 14 patients who were treated with CAR T cells for active disease but didn't undergo blood stem cell transplantation showed disease regression with a median follow-up of six months. (mdanderson.org)
There are limited effective therapies currently available for EB patients. (researchandmarkets.com)
Patients with head and neck cancers, in particular those treated with radiation therapy are at risk for developing mucositis. (dana-farber.org)
Patients who undergo hematopoietic stem cell transplantation (HSCT) are at risk for developing infections and oral mucositis. (dana-farber.org)
Patients being treated with targeted cancer therapies may be at risk for developing oral complications such as mouth pain, mouth sores, and taste changes. (dana-farber.org)
By comparison, the allogeneic approach relies on a single source of cells to treat many patients and is often described as an 'off-the-shelf' approach. (onenucleus.com)
Dasatinib (Sprycel): Indicated for the treatment of adult patients with chronic myeloid leukemia in chronic, accelerated, or myeloid or lymphoid blast phase who are resistant or intolerant to prior therapy including imatinib. (medscape.com)
In this study 62% of patients (96 out of 154) who received Jakavi had either a complete or a partial response to treatment compared with 39% of patients (61 out of 155) who received another therapy. (europa.eu)
Allogeneic stem cell transplantation can prolong the survival of patients with NUP98-rearranged acute myeloid leukemia. (stembook.org)
Application of prophylactic or pre-emptive therapy after allogeneic transplantation for high-risk patients with t(8;21) acute myeloid leukemia. (stembook.org)
Efficacy of venetoclax combined with decitabine conditioning regimen for allogeneic hematopoietic stem cell transplantation in high-risk and elderly patients with myeloid neoplasms. (stembook.org)
Moderate to severe marrow fibrosis as a more advanced risk factor for MDS and MDS-AML patients with excess of blasts receiving allogeneic hematopoietic stem cell transplantation. (stembook.org)
The outcome of acute leukemia patients with SET-NUP214 fusion after allogeneic stem cell transplantation. (stembook.org)
Posaconazole oral suspension as salvage therapy for invasive fungal disease in patients with hematological diseases. (stembook.org)
Refractory patients with favorable/intermediate-risk acute myeloid leukemia benefit from azacytidine maintenance therapy following allogeneic hematopoietic stem cell transplantation. (stembook.org)
Adult patients with relapsed or refractory mantle cell lymphoma (MCL). (nih.gov)
Adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). (nih.gov)
This phase II clinical trial studies how well dasatinib followed by stem cell transplant works in treating older patients with newly diagnosed acute lymphoblastic leukemia. (uchicagomedicine.org)
REMISSION INDUCTION THERAPY (RIT): Patients receive dasatinib orally (PO) daily continuously and dexamethasone PO or intravenously (IV) on days 1-7. (uchicagomedicine.org)
patients who achieve a hematologic and morphologic CR continue on to CNS prophylaxis therapy. (uchicagomedicine.org)
The new generation tyrosine kinase inhibitor improves the survival of chronic myeloid leukemia patients after allogeneic stem cell transplantation. (cdc.gov)

Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. (nih.gov)
Myelodysplastic syndromes (MDS) are clonal stem cell disorders characterized by peripheral blood cytopenia due to ineffective hematopoiesis and by their potential to evolve into acute myeloid leukemia (AML) 1 . (nature.com)
The autologous approach is illustrated by Kymriah, the pioneering CAR T cell therapy for acute lymphoblastic leukaemia which was approved by the US Food and Drug Administration in 2017. (onenucleus.com)
Myeloproliferative diseases are a heterogeneous group of disorders characterized by cellular proliferation of one or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. (medscape.com)
Mature plasmacytoid dendritic cells associated with acute myeloid leukemia show similar genetic mutations and expression profiles to leukemia cells. (cdc.gov)
CD19 cell-depleted HLA-haploidentical transplantation to treat pediatric acute leukemia: updated final analysis. (cdc.gov)

Cite this: Immunotherapy of Solid Tumors: Nonmyeloablative Allogeneic Stem Cell Transplantation - Medscape - Jun 27, 2002. (medscape.com)
T cells can destroy tumors. (nih.gov)

Adequate hematologic function, defined as a platelet count >100,000 cells/mm3 and an absolute neutrophil count (ANC) >1,000 cells/mm3. (rwjbh.org)

Inhibition of Src arrests the cell cycle at phase G1 and has little effect on the survival of Waldenström macroglobulinemia or normal cells. (wikipedia.org)
The Composite Immune Risk Score predicts overall survival after allogeneic hematopoietic stem cell transplantation: A retrospective analysis of 1838 cases. (stembook.org)
Our group developed the technique of the cultivation of limbal epithelial sheets on human amniotic membrane scaffolds (HAMS) with a xeno-free medium for clinical applications, which showed enhanced survival of limbal stem/progenitor cells 16 . (nature.com)

Fatal and other serious complications can occur in patient who receive allogeneic HSCT before or after being treated with a PD-1/PD-L1 blocking antibody. (nih.gov)

Immune-mediated adverse reactions can occur at any time during or after treatment with KEYTRUDA, including pneumonitis, colitis, hepatitis, endocrinopathies, nephritis, dermatologic reactions, solid organ transplant rejection, and complications of allogeneic hematopoietic stem cell transplantation. (merck.com)
With a pre-treatment evaluation, the oral medicine team can identify and guide management of problems such as infection, fractured teeth or fillings, or periodontal (gum) disease that could contribute to oral complications after cancer therapy begins. (dana-farber.org)
Careful monitoring of oral health is especially important during cancer therapy to prevent, detect, and treat complications as soon as possible. (dana-farber.org)

Emerging therapies, particularly stem cell-based therapies such as ABCB5+ mesenchymal stromal cells (ABCB5+ MSCs), are creating ripples in the industry. (researchandmarkets.com)
ABCB5+ mesenchymal stromal cells (ABCB5+ MSCs) are noteworthy for their special immunomodulatory and anti-inflammatory properties, making them a promising therapeutic option for various chronic inflammatory diseases, including epidermolysis bullosa. (researchandmarkets.com)

Eibl and colleagues [ 5 ] reported the case of a woman with breast cancer treated with an allogeneic SCT from an HLA-identical sibling. (medscape.com)
Waldenström macroglobulinemia (/ˈvældənstrɒm ˌmækroʊˌɡlɒbjəlɪˈniːmiə/ VAL-dən-strom MAK-roh-GLOB-yə-lin-EE-mee-ə, US also /ˈvɑːldənstrɛm -/ VAHL-dən-strem -⁠) is a type of cancer affecting two types of B cells: lymphoplasmacytoid cells and plasma cells. (wikipedia.org)
The immune system fights infection and can affect cancer cells. (nih.gov)
To test the safety of giving T cells expressing a novel fully-human anti-cluster of differentiation 19 (CD19) chimeric antigen receptor (CAR) to people with advanced B-cell cancer. (nih.gov)
People ages 18-73 with a B-cell cancer that has not been controlled by other therapies. (nih.gov)
Targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific types of cancer cells with less harm to normal cells. (lls.org)
The goal of induction is to destroy as many cancer cells as possible in order to achieve (induce) a complete remission. (lls.org)
Consolidation therapy," also called "post-remission therapy," is treatment that is given after cancer is in remission following induction therapy. (lls.org)
Merck has an extensive clinical development program in prostate cancer evaluating KEYTRUDA as monotherapy and in combination with LYNPARZA and other anti-cancer therapies. (merck.com)
The secondary endpoints include time to initiation of the first subsequent anti-cancer therapy, objective response rate, duration of response and safety. (merck.com)
Cancer therapy can cause suppression of the immune system and increases the likelihood of developing a dental infection. (dana-farber.org)
Xerostomia/salivary gland dysfunction: Some cancer therapies can result in dryness of the mouth due to thickened saliva, and reduced or absent salivary flow. (dana-farber.org)
Dasatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (uchicagomedicine.org)
Monoclonal antibodies, such as alemtuzumab, may interfere with the ability of cancer cells to grow and spread. (uchicagomedicine.org)

CLL B-lymphocytes typically show B-cell surface antigens, as demonstrated by CD19, CD20dim, CD21, and CD23 monoclonal antibodies. (medscape.com)
Using the Sleeping Beauty gene transfer system, Laurence Cooper, M.D., Ph.D., professor of Pediatrics and Partow Kebriaei, M.D. , associate professor of Stem Cell Transplantation and Cellular Therapy , were able to plug a gene into T cells, creating an artificial or chimeric antigen receptor (CAR) on the T cell that recognizes and binds to CD19, a cell surface on B cells. (mdanderson.org)

The patient was treated with chemotherapeutic drugs (cyclophosphamide, vincristine, therarubicin, and cisplatin), irradiation of the abdominal cavity, and surgical resection of the adrenal gland, followed by autologous peripheral blood stem cell transplantation (PBSCT). (biomedcentral.com)
Morphologically, in the peripheral blood, these cells resemble mature lymphocytes. (medscape.com)
A) Peripheral blood smear showing many hypochromic and microcytic cells. (haematologica.org)
Determine the feasibility of collecting adequate peripheral blood stem cells for autologous HCT following dasatinib therapy and assess for residual Ph+ (BCR/ABL+) cells by Q-PCR. (uchicagomedicine.org)

Therefore, in this article, we summarize the current status of mesenchymal stem cell therapies in infertility pathophysiology and discuss potential areas of further research in regenerative medicine. (hindawi.com)

During corneal epithelial wound healing, cells displaying stem/precursor cell features undergo a large expansion within the limbal niche and, subsequently, in the cells outgrowing from limbal biopsies set in explant culture 6 . (nature.com)

The Barrett group has carried out clinical trials in stem cell transplantation (SCT) as a treatment for leukemia for over 23 years at NIH. (nih.gov)
A clinical trial demonstrating the safety of infusions of virus specific lymphocyte infusions to prevent multiple virus infections has been completed and a trial of leukemia specific T cell infusions is now being developed. (nih.gov)
An emerging concept from this work is that leukemia cells develop multiple ways to switch off the immune response that might otherwise successfully eradicate the leukemia. (nih.gov)
Furthermore the group plans to develop a comprehensive knowledge of the antigens on leukemia cells that render them targets for immune attack. (nih.gov)
The goal of consolidation therapy is to lower the number of residual leukemia cells in the body, or eliminate them entirely to help prevent the leukemia from returning. (lls.org)
Without additional therapy, the leukemia is likely to relapse within weeks or months. (lls.org)
Define a leukemia stem cell and its relationship to disease kinetics in so far as current knowledge permits. (esh.org)

Iodine-131-metaiodiobenzylguanidine ( 131 I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma. (biomedcentral.com)
We decided to perform cord blood stem cell transplantation (CBSCT) for hematopoietic rescue after the myeloablative therapies. (biomedcentral.com)
Thus far, most of the approved allogeneic therapies are cord blood products for stem cell transplantation procedures. (onenucleus.com)

MicroRNA-155 regulates the proliferation and growth of Waldenström macroglobulinemia cells in vitro and in vivo, by inhibiting MAPK/ERK, PI3/AKT, and NF-κB pathways. (wikipedia.org)
Mesenchymal stem cells (MSCs) are multipotent stem cells with abundant source, active proliferation, and multidirectional differentiation potential. (hindawi.com)
65). Expression of the proliferation marker Ki67, stem/progenitor cell markers p63α and ABCG2, cornea specific marker PANCK, and differentiation marker CK12 were evaluated. (nature.com)

V. Study the safety and efficacy of reduced-intensity preparatory regimen followed by an allogeneic HCT following induction therapy with dasatinib. (uchicagomedicine.org)

Waldenström macroglobulinemia cells show only minimal changes in cytogenetic and gene expression studies. (wikipedia.org)
Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic anemia caused by an acquired defect of the phosphatidylinositol glycan anchor ( PIGA ) gene , which leads to dysfunction of a red cell membrane protein (glycosylphosphatidylinositol) that is normally responsible for protecting RBCs from complement-mediated destruction. (amboss.com)
Allogeneic haematopoietic stem-cell transplantation versus gene therapy for haemoglobinopathies. (ucsf.edu)
Allogeneic Transplant and Gene Therapy: Evolving Toward a Cure. (ucsf.edu)
Krystal has taken the lead in the race for gene therapy treatments for Epidermolysis Bullosa (EB) by securing FDA approval for VYJUVEK, which is effective for both the recessive and dominant forms of the condition. (researchandmarkets.com)
It is often said that cell and gene therapies are a 'process' rather than typical drugs. (onenucleus.com)
This could be an autologous chimeric antigen receptor (CAR) T cell-based gene therapy, or any one of the many allogeneic products in clinical development. (onenucleus.com)
In the case of cell and gene therapy products, the manufacturing step is the development plan - at least initially. (onenucleus.com)
and the use of primate models for gene therapy. (nih.gov)
Extensive facilities are available for pre-clinical trials in non-human primates and for human gene therapy. (nih.gov)

These heterogenity of MDS have led to the development of risk-based stratification systems, and treatment options such as hypomethylating agent (HMA) or allogeneic stem cell transplantation (SCT) are selected systematically according to risk groups 9 , 10 , 11 . (nature.com)
The first phase of your treatment is induction therapy. (lls.org)
What Type of Treatment Is Used for AML Consolidation Therapy? (lls.org)
Stem cell-based therapies cast a new hope for infertility treatment as a replacement or regeneration strategy. (hindawi.com)
Speakers at this meeting will present the newest and often unpublished data that relate to the (1) Biology of CML including the origin of BCR-ABL1, signal transduction, basis of disease progression, action of tyrosine kinase inhibitors and mechanisms underlying resistance to TKI, and (2) Aspects of treatment including prediction and definition of responses, drugs used in combination, modern diagnostics and molecular monitoring, targeting residual stem cells and approaches to cure. (esh.org)
These immunomodulatory and anti-inflammatory cells offer promising treatment options for EB, among other chronic inflammatory diseases. (researchandmarkets.com)
Anemia caused by occult bleeding, hemolysis, marrow replacement, or a nutritional deficiency is unlikely to respond to epoetin treatment but may be corrected using other therapies. (webharvest.gov)
Red blood cell (RBC) transfusion has long been the primary treatment of severe or life-threatening anemia. (webharvest.gov)
But transfusion is used cautiously in the treatment of moderate and mild anemia because of the risks associated with exposure to allogeneic blood products and concern to conserve the blood supply. (webharvest.gov)

It is commonly classified as a form of plasma cell dyscrasia, similar to other plasma cell dyscrasias that, for example, lead to multiple myeloma. (wikipedia.org)
The Waldenström macroglobulinemia spectrum of dysplasias differs from other spectrums of plasma cell dyscrasias in that it involves not only aberrant plasma cells but also aberrant lymphoplasmacytoid cells and that it involves IgM while other plasma dyscrasias involve other antibody isoforms. (wikipedia.org)

A mixed immune cluster was increased in FCR ( Fig 1B ) and characterized by PD-L1 checkpoint and T cell receptor signaling pathways. (asn-online.org)
Dosing of TECARTUS is based on the number of chimeric antigen receptor (CAR)-positive viable T cells. (nih.gov)

At the meeting, panellists said there are currently two main sources for the new allogeneic cell therapies: cells from healthy donors and iPSCs. (onenucleus.com)
Our results imply that donors younger than 65 years of age are a better source of limbal epithelial stem cell sheet generation with high regeneration potential. (nature.com)

Study the safety and efficacy of autologous HCT following therapy with dasatinib. (uchicagomedicine.org)

100,000 cells) identified 17 unique cell clusters, including monocytes, natural killer (NK) and T cell subclusters ( Fig 1A ). (asn-online.org)

Erythropoietin is an endogenous hormone, produced primarily in the kidney, which participates in regulating production of red blood cells (erythropoiesis). (webharvest.gov)

Epoetin (with red blood cell transfusion used as necessary) was compared to red blood cell transfusion alone. (webharvest.gov)

Multicenter Long-Term Follow-Up of Allogeneic Hematopoietic Cell Transplantation with Omidubicel: A Pooled Analysis of Five Prospective Clinical Trials. (ucsf.edu)
The resultant product known as CAR T cells are produced at MD Anderson and are being employed in the Sleeping Beauty clinical trials. (mdanderson.org)

Assess the role of allogeneic stem cell transplantation in the management of CML. (esh.org)

Radiation therapy to the head and neck also may also cause long-term damage to the salivary glands, which can result in discomfort due to chronic dry mouth, and increased rate of dental caries (cavities). (dana-farber.org)

They will get the T cells through the IV in 1 infusion. (nih.gov)
TECARTUS is available as a cell suspension for infusion. (nih.gov)

There was a higher proportion of cells in S phase from FCR, indicating early alterations in transcriptional activity ( Fig 1C ). (asn-online.org)

Anatomy30

Organisms11

Diseases47

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment84

Psychiatry and Psychology2

Phenomena and Processes31

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science4

Named Groups5

Health Care23

Geographicals1

Chemotherapy16

Graft-versus-5

Curative6

Malignancy2

Marrow Transplantation4

Transplant Cell Ther1

Outcomes5

Bone13

Myeloablative allogeneic2

Donor6

Patients52

Acute6

Tumors2

Hematologic1

Survival3

HSCT1

Complications3

Mesenchymal stromal cells2

Cancer14

CD192

Peripheral blood4

Pathophysiology1

Undergo1

Leukemia7

Cord blood3

Proliferation3

Regimen1

Gene10

Treatment9

Plasma cell dyscrasias2

Receptor2

Donors2

Efficacy1

100,000 cells1

Kidney1

Blood cell transfusion1

Clinical trials2

Assess1

Chronic1

Infusion2

Phase1