Cells tfap2a gene expression. Medical search. Frequent questions

The TFAP2-alpha gene was isolated and found to be retinoic acid-inducible in NT2 teratocarcinoma cells suggesting a potential role for AP-2 alpha in cellular differentiation. (wikipedia.org)
Measuring gene expression in specific cellular subsets is key to understanding cellular function and differentiation and how these processes are disrupted during disease pathogenesis. (biomedcentral.com)
It is these differentially expressed genes that frequently control cell differentiation, define cell-specific phenotypes, and provide the core signature of cell identity. (biomedcentral.com)
DNA methylation is considered among the most prominent epigenetic mechanisms in controlling the functions of genes related to cell differentiation, cell cycle, cell survival, autophagy, and embryo development. (ehu.eus)
DNA methyl transferases (Dnmts) control DNA methylation, the levels of which are differentially altered during embryonic development, and may determine cell differentiation fate as in the case of pluripotent inner cell mass (ICM) or trophectoderm (TE). (ehu.eus)
SOX transcription factors play key roles in cell differentiation and cell fate determination during development. (ehu.eus)
Our analysis showed that Sox4 , Sox5 , Sox9 , Sox11 , and Sox12 are mainly expressed in mesenchymal stem/stromal cells (MSCs) representing osteogenic cells at different stages of differentiation. (ehu.eus)
In addition, Sox family genes colocalized with Runx2 and Lef1 , which are highly enriched in MSCs undergoing osteoblast differentiation. (ehu.eus)
Secretory epithelial cells display lactogenic differentiation which is characterized by the expression of milk protein genes, such as beta-casein or whey acidic protein (WAP). (biomedcentral.com)
To explore whether the downregulation of AP-2alpha and AP-2gamma is of functional significance for lactogenic differentiation, we analyzed the expression of the AP-2 family members during the lactogenic differentiation of HC11 mammary epithelial cells in vitro. (biomedcentral.com)
Differentiation of HC11 cells was induced following established protocols by applying the lactogenic hormones prolactin, dexamethasone and insulin. (biomedcentral.com)
Using RT-PCR we could not detect a downregulation of any of these genes during the lactogenic differentiation of HC11 cells in vitro. (biomedcentral.com)
The extent of lactogenic differentiation of HC11 cells in vitro is limited compared to mammary epithelium undergoing secretory differentiation in vivo. (biomedcentral.com)
Downregulation of AP-2 transcription factor genes is not required for lactogenic differentiation of HC11 cells but may functionally be involved in aspects of lactogenic differentiation in vivo that are not reflected by the HC11 system. (biomedcentral.com)
The lactogenic differentiation of the secretory epithelial cells is characterized by the synthesis of lactose and milk fat and by the expression of milk protein genes, such as beta-casein or whey acidic protein (WAP). (biomedcentral.com)
HC11 cells can be induced to undergo lactogenic differentiation by applying a mixture of the lactogenic hormones dexamethasone, insulin and prolactin (a mixture termed DIP in the following sections). (biomedcentral.com)
In this report we analyzed AP-2 transcription factor expression in HC11 cells subjected to lactogenic differentiation conditions. (biomedcentral.com)
For induction of differentiation, cells were grown to confluency and then kept in medium without EGF for 48 hours to induce competence. (biomedcentral.com)
This gene is expressed in neural crest cell lineages with the highest levels of expression corresponding to early neural crest cells, suggesting that TFAP2A plays a role in their differentiation and development. (csb-bioenergetics.nl)
Allelic deficiency, modeled by phox2b morpholino knockdown, led to a decrease in the terminal differentiation markers th and dbh in sympathetic ganglion cells. (prolekarniky.cz)
This effect on terminal differentiation is associated with an increased number of phox2b + , ascl1 + , elavl3 − cells that respond poorly to retinoic acid. (prolekarniky.cz)
These findings suggest that a reduced dosage of PHOX2B during development, through either a heterozygous deletion or dominant-negative mutation, imposes a block in the differentiation of sympathetic neuronal precursors, resulting in a cell population that is likely to be susceptible to secondary transforming events. (prolekarniky.cz)
A defining feature of neuroblastic tumors is their broad spectrum of cellular differentiation, ranging from undifferentiated cells that indicate a poor prognosis to those showing greater differentiation and predicting a generally favorable outcome [2] . (prolekarniky.cz)
This heterogeneity suggests that dysregulated differentiation of sympathetic progenitor cells plays a key role in neuroblastoma pathogenesis. (prolekarniky.cz)
Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and signaling pathways that orchestrate renal progenitor cell fate choices and regulate differentiation. (mdpi.com)
Mosaic analyses reveal that Id2a function in facilitating both cell cycle progression and neuronal differentiation in the retina is non-cell-autonomous, suggesting that Id2a functions upstream of the extrinsic pathways that regulate retinogenesis. (biologists.com)
The transcriptomes of 2684 single cells were profiled by CelSeq at different timepoints throughout a 54-day differentiation protocol that converted H1 human embryonic stem cells to a variety of brain cell types. (uth.edu)
We engineered SOX2Cit/+ and DCXCit/Y hESC lines to target progenitors and neurons throughout neural differentiation for single-cell transcriptomic profiling, then identified discrete cell types consisting of both rostral (cortical) and caudal (mid/hindbrain) identities. (uth.edu)

The analysis entails both evaluation of lineage-specific markers and known interactors with the two transcription factors and the involved pathways, as well as an unbiased assessment via single-cell transcriptomic approaches. (ugent.be)
Freiburgers mentioned the download advanced mass spectrometry for food safety and quality volume cell over analgesic tract pathways alone, and also the Tuition is ResearchGate snRNP. (evakoch.com)
The most responsible genes and pathways involved in the pathology of this disorder have not been fully understood. (genominfo.org)
We aimed to identify differentially expressed genes (DEGs), the most critical hub genes, transcription factors, signaling pathways, and biological processes (BPs) associated with the pathogenesis of primary SGC. (genominfo.org)
The most significant pathways and BPs that were deregulated in the primary disease condition were associated with the cell cycle and fibroblast proliferation procedures. (genominfo.org)
Despite many types of investigation that have been performed, the most critical genes and signaling pathways taking part in the etiology of the disease have not been fully demonstrated [ 5 ]. (genominfo.org)

By focusing on identifying differentially expressed genes, it turns a more complex model-fitting problem into a classification problem [ 9 ], opening the door to algorithms that may be more sensitive, especially for rare and difficult-to-isolate cell types. (biomedcentral.com)
A total of 137 genes were found to be differentially expressed in primary SGC. (genominfo.org)

Transcription factor AP-2 alpha (Activating enhancer binding Protein 2 alpha), also known as TFAP2A, is a protein that in humans is encoded by the TFAP2A gene. (wikipedia.org)
Transcription factor AP-2 alpha is a 52-kD sequence-specific DNA-binding protein that enhances transcription of specific genes by binding to a GC-rich DNA sequence first identified in the cis-regulatory region of SV40 virus DNA and in cis-regulatory regions of a variety of cellular genes. (wikipedia.org)
Green signals indicate Nanog protein located in the nuclei of inner cell mass, blue signals (with Hoechst 33342) show the cell nuclei. (ehu.eus)
Differentiating HC11 cells displayed lower expression levels of milk protein genes than mammary glands of mid-pregnant or lactating mice. (biomedcentral.com)
Description: AP2 alpha, or BOFS, is a protein that in humans is encoded by the TFAP2A gene. (csb-bioenergetics.nl)
This protein activates the transcription of some genes while inhibiting the transcription of others. (csb-bioenergetics.nl)
when ZG16B-CXCR4-TLR2 downstream sensor protein kinase A (PKA) is activated, it can inhibit TLR2-induced activation of NF-κB, thereby curbing the activation of immune cells. (cusabio.com)
After pathway enrichment and gene ontology analysis, the protein-protein, microRNA (miRNA)-mRNA, and miRNA-long noncoding RNA (lncRNA) interactions and networks were determined for the selected genes using integrated bioinformatics analyses. (ac.ir)
Lastly, depending on the outcome of Tfap2c/TFAP2C and Gata3/GATA3 knock-out, I will also knock-out highly similar protein isoforms (TFAP2a/c and GATA2/3) to unravel potential functional redundancy in human, as has been shown previously in mouse. (ugent.be)
events have receptors stimulated with students( GAGs), unregulated chains docking of a inactive actin, all of an been protein respiration cell a considerable subunits. (evakoch.com)
Tissue with high expression from Human Protein Atlas . (glycosmos.org)
This subtype is due to a mutation in the APP gene (21q21.2), encoding the beta-amyloid precursor protein. (findzebra.com)
Figure 2:Western blot analysis using TFAP2A mAb against human TFAP2A (AA: 105-211) recombinant protein. (promab.com)

These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)

It has been noted that ZG16B is a mammalian lectin containing a β-prism fold structure, which contributes to the ability to regulate cell adhesion, metastasis, apoptosis, angiogenesis, and cell-cell interactions to recognize pathogens ( Figure 1 ) [2 ， 23] . (cusabio.com)
Here, it is demonstrated that TGFβ facilitates Tβ4 expression and leads to the activation of myocardin-related transcription factors (MRTF), which are coactivators of serum response factor (SRF) and regulate the expression of genes critical for the epithelial-mesenchymal transition (EMT) and tumor metastasis. (aacrjournals.org)
MKL1 and MKL2 ), or robust SRF transcriptional coactivators, have been reported to organize actin cytoskeletal rearrangement and regulate cell motility by controlling the expression of dozens of cytoskeletal/adhesion genes ( 4-6 ). (aacrjournals.org)
SPIB , FOXM1 , and POLR2A significantly regulate all the hub genes. (genominfo.org)
Micha's interest lies in discovering mechanisms that regulate the formation of the embryonic tissues using iPS cells, in order to create novel models for human disease and drug development with emphasis on neurodegeneration. (universiteitleiden.nl)

Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. (nih.gov)

CellMapper takes as input (1) a large set of gene expression data and (2) a query gene (or genes) specifically expressed in the cell type of interest and then estimates the probability that every other gene in the dataset is co-expressed with the query gene (Fig. 1a ). (biomedcentral.com)

During embryonic development, AP-2 alpha is expressed in neural crest cells migrating from the cranial neural folds during neural tube closure, and is also expressed in ectoderm, parts of the central nervous system, limb buds, and mesonephric system suggesting that AP-2 alpha plays an important role in the determination and development of these tissues. (wikipedia.org)
Cranial neural crest cells populate the developing face and provide patterning information for craniofacial morphogenesis and generate most of the skull bones and the cranial ganglia. (wikipedia.org)
Neural crest cells (NCCs) are multipotent progenitor cells unique to vertebrates, and they have the ability to differentiate into a variety of cells, such as chondrocytes, neurons, and melanocytes. (chinagene.cn)
Research progress on neural crest cells and neurocristopathies and its pathogenesis[J]. Hereditas(Beijing), 2022, 44(2): 117-133. (chinagene.cn)

Sequencing of candidate genes in that region in 4 additional unrelated BOFS patients revealed 4 different de novo missense mutations in the exons 4 and 5 of the TFAP2A gene. (wikipedia.org)
We demonstrate a clinically relevant application to prioritize candidate genes in disease susceptibility loci identified by GWAS. (biomedcentral.com)
Finally, we explore a clinically relevant application to prioritize candidate genes in loci identified by genome-wide association studies (GWAS). (biomedcentral.com)

ZG16B expression induces phosphorylation of ser-33/37/Thr-41 and ser-675 of β-catenin to activate the Akt/GSK-3β signaling pathway, and then β-catenin is translocated to the nucleus where it forms a complex with the T-cell factor/lymph node enhancer factor (TCF/LEF) family. (cusabio.com)
He combines subjects such as Enhancer, Embryonic stem cell, Molecular biology and Effector with his study of Interferon regulatory factors. (research.com)
His work carried out in the field of Interferon regulatory factors brings together such families of science as Enhancer, Embryonic stem cell, Molecular biology and Effector. (research.com)
Tβ4 levels are transcriptionally regulated via the novel cis -acting element AGACAAAG, which interacts with Smad and T-cell factor/lymphoid enhancer factor (TCF/LEF) to synergistically activate the Tβ4 promoter downstream of TGFβ. (aacrjournals.org)

Recent studies have confirmed that ZG16B is not just highly expressed in pancreatic cancer cells, but also in breast cancer, gastric cancer, and ovarian cancers. (cusabio.com)

Exogenous IL1β stimulated the proliferation and reactivity of microglia in the absence of damage, reduced numbers of dying cells in damaged retinas, and increased neuronal survival following an insult. (biomedcentral.com)
These findings demonstrate that it plays key roles in the proliferation, adhesion, migration, and invasion in different tumor cells [1-4] . (cusabio.com)
This complex can activate the expression of β-catenin-responsive genes to accelerate the proliferation of pancreatic cancer cells [9] . (cusabio.com)
Id2a-dependent defects in retinoblast proliferation lead to microphthalmia and to an absence of nearly all differentiated inner and outer nuclear layer cell types. (biologists.com)

NS represents no significant differential expression between two groups was detected by using the BPSC method. (uth.edu)

Id2a-deficient retinas possess increased numbers of cells occupying S phase, at the expense of mitotic cells, and kinetic analyses demonstrate that Id2a is required for S-phase progression and/or the transition from S to M phase. (biologists.com)
Kaplan-Meier survival analyses demonstrate that high Tβ4 expression associates with poor prognosis in an SRF expression-dependent manner in several cancers. (aacrjournals.org)

These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)
These SNPs, however, are still thought to account for less than half of all genetic susceptibility to IS, with a number of yet to be discovered genes also contributing to the development of IS. (hindawi.com)

Much of this process relies on the morphogenesis of the extra-embryonic tissues and the effect this has on the organization of embryonic cells. (nature.com)
Furthermore, CellMapper makes accurate predictions for human brain cell types that have never been isolated, and can be rapidly applied to diverse cell types from many tissues. (biomedcentral.com)
As a result, expression data are only available for a small fraction of the ~150 cell types [ 7 ] of the human central nervous system and this problem is similar for many other tissues. (biomedcentral.com)
We then apply our algorithm to a large compendium of 19,801 microarrays and identify genes specifically expressed in 30 diverse cell types of widespread importance in human biology, demonstrating that CellMapper can be readily used for cell types from many different tissues. (biomedcentral.com)
Direct comparison of the cell types were made to primary tissues using gene expression atlases and fetal human brain single-cell gene expression data, and this established that the cell types resembled early human brain cell types, including preplate cells. (uth.edu)
Stacked bar graphs showing different patterns of enriched spatial expression based on RNA-seq of dissected gastrula tissues (Blitz et al. (xenbase.org)

Identification of gene expression profiles, RNA interactions, gene regulation patterns, and single nucleotide polymorphisms (SNPs) is important for determining the molecular mechanisms underlying the normal odontogenesis and the pathology of oral and dental disorders. (ac.ir)
2016. In silico analysis of deleterious single nucleotide polymorphisms in human BUB1 mitotic checkpoint serine/threonine kinase B gene. (ac.ir)

They share a conserved structure and control gene expression by binding to the respective promoters as homo- or heterodimers. (biomedcentral.com)

Patients with ureteroscopic biopsy (n = 3/5) showed identical mutational changes for common genes (TP53 and FGFR3) between primary UTUC and subsequent UBR. (bvsalud.org)

GAS5 is found on chromosome 1q25.1, with the gene containing 12 exons across a 4.087 kb region, coding for 29 different GAS5 splicing variants [ 11 ]. (hindawi.com)

activated leukocyte cell adhesion mole. (gsea-msigdb.org)

We present a sensitive approach to predict genes expressed selectively in specific cell types, by searching publicly available expression data for genes with a similar expression profile to known cell-specific markers. (biomedcentral.com)

Murine skin melanoma cells (B16F0 and B16F1) also show the expression regulation of Tβ4 by Smad and TCF/LEF. (aacrjournals.org)
The lab focuses on multifaceted regulation by transcription and epigenetic factors, lncRNAs, membraneless organelles, mechanisms of self-renewal, and extensively uses organoid technology, single cell RNA sequencing, flow cytometry, and CRISPR-Cas9 genetic engineering approaches. (universiteitleiden.nl)

Therefore, this in silico study aimed to identify novel proteins, RNA interactions, and deleterious SNPs related to four major genes ( MSX2 , SHH , SMAD7 , TFAP2 ) involved in the odontogenesis process. (ac.ir)

I will focus on TFAP2C and GATA3, two master regulators of TE, and will document their expression and localization during different stages of mouse/human embryonic development, and assess the consequences of their knock-out by CRISPR/Cas9. (ugent.be)
The hub genes of PIM were discovered, and their associated gene regulatory network was built to determine the master regulators involved in the pathogenesis of primary SGC. (genominfo.org)
This study illustrated several hub genes and their master regulators that might be appropriate targets for the therapeutic aims of primary SGC. (genominfo.org)

The human brain provides a clear example: many brain cell types display abnormal gene expression patterns when grown in culture [ 2 ] and must be acutely isolated from intact brain tissue to insure physiological relevance. (biomedcentral.com)
Collectively, the distinct expression patterns of the SOX transcription factors suggest that they play essential regulatory roles in directing. (ehu.eus)

Following knockdown of Dnmt1 and Dnmt3a in zygotes, expression levels of Cdx2 in the trophectoderm and Nanog in the inner cell mass were measured, as well as p62 levels, reactive oxygen species (ROS) production, and apoptosis levels after 96 hours in embryo culture. (ehu.eus)
Here, we investigated the role of circ-JA760602 in modulating the apoptosis of hypoxia-induced AMI cells using the AC16 cardiomyocyte in vitro cell model. (ehu.eus)

TFAP2A acts as a sequence-specific DNA-binding transcription factor recognizing and binding to the specific DNA sequence and recruiting transcription machinery. (csb-bioenergetics.nl)
showed that the GAS5 rs55829688 promoter polymorphism alters the ability of the Yin-Yang 1 (YY1) transcription factor to bind to this region, thereby increasing GAS5 expression and elevated colorectal cancer risk [ 13 ]. (hindawi.com)

Epigenetic mechanisms are one of the essential regulators of gene expression which do not involve altering the primary nucleotide sequence. (ehu.eus)

These algorithms take advantage of the fact that the relative proportion of cell types varies from sample to sample, making it possible to statistically deconvolve expression changes in the underlying cell types. (biomedcentral.com)

Single-cell RNA sequencing was performed to obtain transcriptomic profiles. (biomedcentral.com)
From the single-cell transcriptomic data a Bayesian algorithm generated a unified lineage tree, and predicted novel regulatory transcription factors. (uth.edu)

In particular, the lncRNA growth arrest-specific 5 (GAS5) was found upregulated in both middle cerebral artery occlusion (MCAO) rat models as well as in vitro cell models [ 9 ]. (hindawi.com)

ZG16B, as a new activator of human endothelial cells, has similar effects to vascular endothelial growth factor ( VEGF ), can promote angiogenesis and increase vascular permeability in vitro and in vivo [3] . (cusabio.com)

Here we extend those findings to humans using only genetically unmodified human naive embryonic stem cells (cultured in human enhanced naive stem cell medium conditions) 4 . (nature.com)
We show that CellMapper can make accurate predictions for four human brain cell types that have never been isolated and cannot be addressed by any other computational method. (biomedcentral.com)
RELA tunes innate-like interferon I/III responses in human T cells. (nih.gov)
The Plant Ap2 Antibodies reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (csb-bioenergetics.nl)
Description: Quantitative sandwich ELISA for measuring Human Anti-cardiolipin antibodies IgG (ACA-IgG) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (csb-bioenergetics.nl)
During development of the human brain, multiple cell types with diverse regional identities are generated. (uth.edu)
Here we report a system to generate early human brain forebrain and mid/hindbrain cell types from human embryonic stem cells (hESCs), and infer and experimentally confirm a lineage tree for the generation of these types based on single-cell RNA-Seq analysis. (uth.edu)
In multiple human cancers, Tβ4 levels correlate positively with TGFβ1 and the tumor-associated gene expression levels through processes that respectively depend on TGFβ receptor 1 (TGFBR1) and MRTF expression. (aacrjournals.org)
It can also refer to gene MLC1 or Megalencephalic leukoencephalopathy with subcortical cysts 1 , a human gene related to the former disease. (findzebra.com)
Purified recombinant fragment of human TFAP2A (AA: 105-211) expressed in E. Coli. (promab.com)

Mutations in the TFAP2A gene cause Branchio-oculo-facial syndrome often with a midline cleft lip. (wikipedia.org)
Mutations in IRF6 gene cause Van der Woude syndrome (VWS) that is a rare mendelian clefting autossomal dominant disorder with lower lip pits in 85% of affected individuals. (wikipedia.org)
Mutations in the AP-2 alpha gene also cause branchio-oculo-facial syndrome, which has overlapping features with Van der Woude syndrome such as orofacial clefting and occasional lip pits what make rs642961 a good candidate for an etiological variant. (wikipedia.org)
21 allelic mutations have been discovered in the APP gene. (findzebra.com)

NMDA-induced damage included neuronal cell death, microglial reactivity, upregulation of pro-inflammatory cytokines, and genes associated with IL1β-signaling in different types of retinal neurons and glia. (biomedcentral.com)

These cells arise within the dorsal ectoderm of all vertebrate embryos and have the developmental potential to form many of the morphological novelties within the vertebrate head. (frontiersin.org)
Each cell population has its own distinct developmental features and generates unique cell types. (frontiersin.org)
1 Section of Molecular Cell and Developmental Biology, Institute for Cell and Molecular Biology, The University of Texas at Austin, Austin, TX 78722, USA. (biologists.com)

These include embryonic disc and bilaminar disc formation, epiblast lumenogenesis, polarized amniogenesis, anterior-posterior symmetry breaking, primordial germ-cell specification, polarized yolk sac with visceral and parietal endoderm formation, extra-embryonic mesoderm expansion that defines a chorionic cavity and a connecting stalk, and a trophoblast-surrounding compartment demonstrating syncytium and lacunae formation. (nature.com)
Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network. (xenbase.org)
A) Endoderm expression of sox17a and sox17b in NF10.5 Xenopus tropicalis gastrula . (xenbase.org)
C) Sox17 -bound genes are enriched in the endoderm . (xenbase.org)

Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 16 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 16 h. (gsea-msigdb.org)

In murine mammary gland cells (NMuMG), Tβ4 upregulation is required for full induction of a MRTF-regulated EMT gene expression program after TGFβ stimulation. (aacrjournals.org)

His primary areas of investigation include Genetics, Gene, Molecular biology, IRF6 and Van der Woude syndrome. (research.com)
His main research concerns Genetics, IRF6, Van der Woude syndrome, Gene and Molecular biology. (research.com)
His IRF6 study combines topics from a wide range of disciplines, such as TFAP2A, Endocrinology, Exome and Cell biology. (research.com)
Prof. Dr. Micha Drukker is a professor of Stem Cell Biology, Models and Regenerative medicine at the Division of Drug Discovery & Safety. (universiteitleiden.nl)

Four transcript variants encoding different isoforms have been found for this gene. (nih.gov)
Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. (research.com)

Description: A competitive ELISA for quantitative measurement of Canine Platelet antibodies IgG in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (csb-bioenergetics.nl)

Mouse naive embryonic stem cells have recently been shown to give rise to embryonic and extra-embryonic stem cells capable of self-assembling into post-gastrulation structured stem-cell-based embryo models with spatially organized morphogenesis (called SEMs) 3 . (nature.com)
In some cases, Sox17 and β-catenin synergistically activate transcription apparently independent of Tcfs, whereas on other enhancers, Sox17 represses β-catenin/Tcf-mediated transcription to spatially restrict gene expression domains. (xenbase.org)

In vivo gene delivery of AP-2 alpha suppressed spontaneous intestinal polyps in the Apc(Min/+) mouse. (wikipedia.org)

RELA promotes the progression of oral squamous cell carcinoma via TFAP2A-Wnt/β-catenin signaling. (nih.gov)
Although enhanced thymosin β4 (TMSB4X/Tβ4) expression is associated with tumor progression and metastasis, its tumor-promoting functions remain largely unknown. (aacrjournals.org)

Genetic factors are the main risk factors for NCPs, but environmental factors and abnormal gene-environment interactions can also lead to the development of NCPs. (chinagene.cn)

Moreover, the potential deleterious SNPs in the selected genes were identified and finally, their validation and implications on the structure of proteins were investigated by specific bioinformatics tools. (ac.ir)

Nanog expression in mouse blastocyst. (ehu.eus)
Using single-cell RNA-sequencing data, we examined the expression profiles of Sox genes in the mouse incisor dental pulp. (ehu.eus)
Disrupted expression in sox17 -MOs is rescued by co-injection of mouse (m) Sox17 RNA. (xenbase.org)
Mouse over or click genes or lines for details. (ucsc.edu)
Figure 4:Western blot analysis using TFAP2A mouse mAb against Hela (1), PANC-1 (2), HEK293 (3), and RAW267.4 (4) cell lysate. (promab.com)
Figure 5:Flow cytometric analysis of Hela cells using TFAP2A mouse mAb (green) and negative control (red). (promab.com)

His study in Van der Woude syndrome is interdisciplinary in nature, drawing from both Linkage disequilibrium, Popliteal pterygium syndrome, TFAP2A, Haploinsufficiency and Genotype. (research.com)
His primary scientific interests are in IRF6, Genetics, Van der Woude syndrome, Gene and Interferon regulatory factors. (research.com)

A search of NSCL/P cases for potential regulatory elements for IRF6 gene was made aligning genomic sequences to a 500 Kb region encompassing IRF6 from 17 vertebrate species. (wikipedia.org)

Microglia are the innate immune cells of the central nervous system and are derived from erythro-myeloid precursor cells that originate in the yolk sac during early stages of development [ 2 ]. (biomedcentral.com)

Only MMP2-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. (ucsc.edu)
Please see the Gene Interactions Track Manual . (ucsc.edu)

One promising solution has been the development of computational methods to infer cell type-specific expression information directly from heterogeneous samples [ 8 - 19 ], such as undissociated tissue. (biomedcentral.com)

For example, TGFβ induces the phenotypic transition of various types of cells into mesenchymal, myofibroblast, and smooth muscle-like cells, accompanied by dramatic cytoskeletal remodeling and increased cell motility ( 2, 3 ). (aacrjournals.org)

Genes & Development. (wikipedia.org)
at the same time, it can also activate myeloid-derived suppressor cells (MDSCs) and promote tumor development, which has a dual role in immunotherapy [5-7] . (cusabio.com)
The vertebrate head is a complex tapestry of morphological features woven together during embryonic development from a varied array of specialized cell types. (frontiersin.org)
Hence, one way to decipher the tumorigenic contribution of germline changes in highly conserved genes such as PHOX2B is to understand how they perturb normal development. (prolekarniky.cz)

Anatomy24

Organisms18

Diseases10

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes98

Disciplines and Occupations4

Information Science7

Health Care3

Differentiation28

Pathways6

Differentially2

Protein13

Phenotypes2

Regulate5

Activates1

Dataset1

Neural4

Candidate genes3

Enhancer4

Gastric cancer1

Proliferation4

Differential expression1

Analyses2

Susceptibility2

Tissues6

Single nucleotide po2

Homo1

TP531

Chromosome1

Adhesion1

Markers1

Regulation2

TFAP21

Master regulators3

Patterns2

Apoptosis2

Transcription factor2

Regulators1

Statistically1

Transcriptomic2

Vitro cell1

Endothelial cells1

HUMAN10

Mutations4

Neurons1

Developmental3

Endoderm4

Dendritic1

Murine mammary1

Biology4

Variants2

Antibodies1

Spatially2

Vivo1

Progression2

Abnormal1

Bioinformatics1

Mouse6

Woude2

Genomic1

Yolk sac1

Interactions2

Infer1

Motility1

Development4