Cells stem cell transplants transplant bone marrow transplantation. Medical search. Frequent questions

An autologous transplant uses the patient's own stem cells, collected in advance and returned to them after they receive high doses of chemotherapy. (leukaemia.org.au)
Stem cells from your own body (also called an autologous transplant). (cdc.gov)
I would be interested in hearing from anyone who has been cured from just chemo alone and/or an autologous transplant. (cancer.org)
My son was cured with an autologous transplant from his mom in 1996, he was 8 at the time. (cancer.org)

The steps are much the same, no matter what type of transplant you're going to have. (cancer.org)
This type of transplant is also called an allogeneic stem cell transplant. (macmillan.org.uk)
The type of transplant you are given depends on a number of factors. (leukaemia.org.au)
There are different reasons for receiving either type of transplant. (cdc.gov)

High-dose chemotherapy aims to destroy disease but, as an unwanted effect, it may also destroy the precious blood stem cells , which then need to be replaced. (leukaemia.org.au)
Radiation therapy and chemotherapy are the most common treatments for Hodgkin's lymphoma, although bone marrow transplantation , peripheral stem cell transplantation and biological therapies are currently being studied in clinical trials. (ucsfhealth.org)
Chemotherapy uses drugs to kill cancer cells. (ucsfhealth.org)
BMT usually involves high-intensity treatment with chemotherapy and radiation to kill abnormal cells, which affects all systems of the body. (nih.gov)
To determine if a research BMT with half-matched donor cells, low-intensity radiation, immunosuppressant drugs, and no chemotherapy will be effective in patients with sickle cell disease and Beta-thalassemia. (nih.gov)
Before you have a transplant, you need to get high doses of chemotherapy and possibly radiation. (longlifehealthy.com)
By replacing cells that are lost through chemotherapy or radiation therapy, a bone marrow transplant can allow a patient to receive higher and more effective treatment dosages. (moffitt.org)
Giving chemotherapy, such as treosulfan and fludarabine phosphate, and total-body irradiation before a donor stem cell transplant helps stop the growth of cancer cells. (druglib.com)

Although TCD is beneficial to prevent GVHD there are some problems it can cause a delay in recovery of the immune system of the transplanted individual and a decreased Graft-versus-tumor effect. (wikipedia.org)

Early on it was apparent that TCD was good for preventing GVHD, but also led to increased graft rejection, this problem can be solved by transplanting more hematopoietic stem cells. (wikipedia.org)
HMGN1 amplification is associated with increased accessibility, expression, and histone H3K27 acetylation of loci important for hematopoietic stem cells (HSCs) and leukemia, such as HoxA cluster genes. (nature.com)
Hematopoiesis is a highly regulated process requiring both self-renewal and differentiation of hematopoietic stem cells (HSCs) to maintain diverse mature blood components. (nature.com)

Stem cells from a donor (also called an allogeneic transplant). (cdc.gov)

In an allogeneic transplant the stem cells are donated from another person, who is a genetically-matched stem cell donor. (leukaemia.org.au)

The stem cells can develop into red blood cells, which carry oxygen throughout the body, white blood cells, which fight infections, and platelets, which help the blood to clot. (longlifehealthy.com)

Fully matched transplant donors cannot be found for every patient who needs a transplant. (nih.gov)
Donors will undergo apheresis, which involves withdrawing blood from one arm vein, passing it through a machine that removes bone marrow stem cells, and returning the remaining blood through the vein in the other arm. (nih.gov)
Donors will receive a drug that causes the stem cells to be released into the bloodstream prior to the apheresis procedure. (nih.gov)
Cooperation between his research group (University of Helsinki/Helsinki University Hospital/Finnish Red Cross Blood Service) and the New Children's Hospital of the Hospital District of Helsinki and Uusimaa is close, as the Blood Service is responsible for identifying stem cell transplant donors and related logistics. (helsinki.fi)
Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. (mja.com.au)

This procedure is called 'megadose transplantation' and it prevents rejection because the stem cells have an ability (i.e. veto cell killing) to protect themselves from the host's immune system. (wikipedia.org)
A bone marrow transplant is a procedure that replaces a person's faulty bone marrow stem cells. (longlifehealthy.com)
Blood is preferred to bone marrow as a source because the procedure is less invasive and the number (count) of blood cells returns to normal more quickly. (msdmanuals.com)

Radiation therapy, also called radiotherapy, uses high-energy rays to kill cancer cells. (ucsfhealth.org)
Radiation therapy is local therapy, meaning it only affects cancer cells in the treated area. (ucsfhealth.org)
Recipients will receive low-dose radiation in two treatments 1 and 2 days before the transplant. (nih.gov)
Regardless of this notion, the treatment plan was radiation and stem cell transplant. (rdhmag.com)
The radiation dose burns the skin, and kills all cells in the path of the deadly beam. (rdhmag.com)

The diagnosis also depends on a biopsy , during which a surgeon removes a sample of lymphatic tissue (part or all of a lymph node) so a pathologist can examine it under a microscope to check for cancer cells. (ucsfhealth.org)
Lymph node biopsy - Although it is relatively uncommon for leukemia cells to metastasize to lymph nodes, this can sometimes occur, particularly when the condition transforms into Richter's syndrome, a type of lymphoma. (moffitt.org)

Peripheral blood stem cell collection. (medlineplus.gov)
TRANSPLANT: Patients in both arms undergo allogeneic peripheral blood stem cell (PBSC) transplant or bone marrow transplant on day 0. (druglib.com)

Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. (mja.com.au)
Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. (mja.com.au)
Stem cells from umbilical cords are usually used only in children because umbilical cord blood does not contain enough stem cells to use in adults. (msdmanuals.com)

Donor stem cells can be collected in two ways. (medlineplus.gov)
Most donor stem cells are collected through a process called leukapheresis. (medlineplus.gov)
Recipients will receive the donor stem cells through a previously inserted central line. (nih.gov)

An autologous stem cell transplant involves collecting and storing your own stem cells so they can be put back again after treatment. (macmillan.org.uk)
Bone marrow transplantation (BMT), which involves transplanting a donor's marrow stem cells, is capable of curing some congenital anemias. (nih.gov)
Bone marrow transplantation - A bone marrow transplant involves the injection of stem cells into a vein, which can stimulate the production of healthy red blood cells, white blood cells and platelets. (moffitt.org)

People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
The Barrett group has carried out clinical trials in stem cell transplantation (SCT) as a treatment for leukemia for over 23 years at NIH. (nih.gov)
Stem cell transplantation offers the chance of cure for leukemia patients through a unique graft-versus-leukemia GVL effect conferred by an immune reaction of the donor graft against the patient's leukemia. (nih.gov)
GVHD can be controlled through reducing the immunity of the graft and while transplants for leukemia can now be performed with considerable safety, fatal viral infections and disease relapse still reduce the success of SCT as a treatment for leukemia. (nih.gov)
Dr Barrett's approach to improve SCT outcome is to generate in the laboratory immune cells from the donor that are capable of fighting viruses and leukemia without causing GVHD. (nih.gov)
This can be done at the time of transplant by taking lymphocytes from the donor and stimulating them with viral or leukemia antigens. (nih.gov)
Antigen specific lymphocytes can be expanded over a two week culture period and infused into the patient after transplant to boost their immunity against viruses and reduce the risk of leukemia relapse. (nih.gov)
A clinical trial demonstrating the safety of infusions of virus specific lymphocyte infusions to prevent multiple virus infections has been completed and a trial of leukemia specific T cell infusions is now being developed. (nih.gov)
An emerging concept from this work is that leukemia cells develop multiple ways to switch off the immune response that might otherwise successfully eradicate the leukemia. (nih.gov)
Furthermore the group plans to develop a comprehensive knowledge of the antigens on leukemia cells that render them targets for immune attack. (nih.gov)
This is the basis for generating powerful leukemia-specific killer cells that could enhance the GVL response after transplant and eventually extend to the treatment of patients in remission from leukemia to prevent relapse of their disease. (nih.gov)
Through this combined translational and clinical strategy, Dr. Barrett's group is working toward optimizing the tremendous potential that stem cell transplantation holds in curing leukemia and other serious blood and bone marrow disorders. (nih.gov)
HMGN1 overexpression also cooperates with the AML-ETO9a fusion oncoprotein to impair myeloid differentiation and enhance leukemia stem cell (LSC) activity. (nature.com)
One hallmark of leukemia is a block in normal differentiation from hematopoietic stem/progenitor cells (HSPCs) to their mature progeny. (nature.com)
In addition, somatic gain of chromosome 21 is associated with aggressive leukemias, such as iAMP21 B cell acute lymphoblastic leukemia that has multiple extra copies of 21q22 and a very poor prognosis 13 . (nature.com)
If we find drugs that are specific in making large blood stem cells smaller again, we can test whether this improves the health of people who suffer from problems with their blood system -- like anemia and a reduced immune system -- or maybe even help people with leukemia," she says. (sciencedaily.com)
Placement of a venous access device - The surgical implantation of a plastic tube into a large vein in the chest or upper arm can reduce the need for continual needle sticks for drug injections, blood testing and bone marrow transplants, all of which may be recommended during leukemia treatment. (moffitt.org)

Targeted cell therapy is among the latest forms of treatment for leukaemia, entailing the utilisation of T cells from the patient's own immune system. (helsinki.fi)
It may also stop the patient's immune system from rejecting the donor's stem cells. (druglib.com)
The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). (druglib.com)

You are then given the donor's stem cells through a drip (infusion). (macmillan.org.uk)

Stem cell and bone marrow transplants are sometimes used to treat types of cancer including leukaemia, lymphoma and myeloma. (macmillan.org.uk)
In Hodgkin's lymphoma, cells in the lymphatic system grow abnormally and may spread beyond the lymphatic system. (ucsfhealth.org)
We also offer stem cell transplants to many patients with recurrent Hodgkin's lymphoma. (ucsfhealth.org)
The pathologist studies the tissue and checks for Reed-Sternberg cells, which are large abnormal cells usually found with Hodgkin's lymphoma. (ucsfhealth.org)
This Clinical Policy Bulletin addresses hematopoietic cell transplantation for non-hodgkin's lymphoma. (aetna.com)
Aetna considers autologous hematopoietic cell transplantation for the treatment of persons with relapsed or primary refractory (see "Note" below) non-Hodgkin's lymphoma (NHL) medically necessary if the person meets the transplanting institution's protocol eligibility criteria. (aetna.com)

T-cell depletion (TCD) is the process of T cell removal or reduction, which alters the immune system and its responses. (wikipedia.org)
This problem is partially answered by more selective depletion, such as depletion of CD3+ or αβT-cell and CD19 B cell, which preserves other important cells of the immune system. (wikipedia.org)
However, over time, an individual's immune system can no longer continue to replace CD4+ T cells. (wikipedia.org)
Bone marrow is part of our immune system, which protects us from infection and disease. (macmillan.org.uk)
They divide and mature into all the different types of blood cells (red cells, white cells and platelets ), including the cells of our immune system and are therefore vital for our survival. (leukaemia.org.au)
Because stem cell transplants destroy and rebuild your immune system, they increase your risk for fungal infections. (cdc.gov)
It also suppresses your body's immune system so that it won't attack the new stem cells after the transplant. (longlifehealthy.com)
Among other things, we have investigated the regulation of immune system recovery, its monitoring after bone marrow transplantation and the treatment of graft-versus-host reaction. (helsinki.fi)
The stem cell transplant left her with no basic immune system. (rdhmag.com)

Between the U.S. Food and Drug Administration and the European Medicines Agency, six gene therapy products have been approved since 2016 and more than 800 cell- and gene-based therapies are currently in clinical development. (nih.gov)

Allogenic bone marrow transplant is when another person donates bone marrow. (medlineplus.gov)
With an allogenic transplant, the donor's genes must at least partly match the recipient's genes. (medlineplus.gov)
Aetna considers tandem autologous hematopoietic cell transplantion (auto-auto) or tandem autologous hematopoietic cell transplantation followed by allogenic hematopoietic cell transplantation (auto-allo) experimental and investigational for NHL due to a lack of adequate evidence in the peer-reviewed published medical literature of their safety and effectiveness. (aetna.com)

While all transplants are serious procedures, allogeneic transplants are more complicated and therefore carry more short and long-term risks than autologous transplants. (leukaemia.org.au)
Stem cell transplants have many benefits, but they also have risks. (cdc.gov)
Bone marrow transplantation has serious risks. (longlifehealthy.com)

In haploidentical hematopoietic stem cell transplantation, in vivo TCD suppressed lymphocytes early on. (wikipedia.org)

If a donor's HLAs match well with a person who needs a transplant, the donor must give a new blood sample to confirm the match. (medlineplus.gov)

For this type of treatment, bone marrow is collected from a donor. (medlineplus.gov)

If your stem cells come from another person, you will need to take anti-rejection medication. (cdc.gov)
Rapamycin, a drug that can inhibit cell growth, is now used to treat some cancers and to prevent organ transplant rejection, and has raised interest for its ability to extend lifespan in mice and other organisms. (sciencedaily.com)
To determine the effectiveness of cyclophosphamide, an immunosuppressant drug, in preventing rejection of the donor cells. (nih.gov)
Another immunosuppressant drug, cyclophosphamide, will be given in the future as needed to subsets of the recipients to prevent rejection of donor cells. (nih.gov)
4. The so-called "therapeutic cloning", which would be better called "research cloning" because we are still far from therapeutic applications, has been proposed in order to avert the potential immune rejection of embryonic stem cells derived from a donor other than the host. (lifeissues.net)

Bone marrow contains stem cells, which are immature cells that become blood cells. (medlineplus.gov)
It contains immature cells, called stem cells. (longlifehealthy.com)

Before you have a transplant, you need to discuss the transplant process and all its effects with your doctors. (cancer.org)
Doctors can then use the registry to find a matching donor for a person who needs a bone marrow transplant. (medlineplus.gov)

As a result, as the spleen filters the blood, it can sometimes inadvertently destroy too many red blood cells or platelets, leading to anemia. (moffitt.org)

HIV has been confirmed to target CD4+ T cells and destroy them, making T cell depletion an important hallmark of HIV. (wikipedia.org)

TCD can reduce the risk of graft-versus-host disease (GVHD), which is a common issue in transplants. (wikipedia.org)
He is also investigating the ability of a cell therapy approach to treating GVHD with mesenchymal stromal cell (MSC) infusions, which can both suppress the harmful immune reaction and help repair tissues damaged by GVHD. (nih.gov)

The National Institutes of Health launched a new collaboration to fund research that may lead to curative strategies for sickle cell disease (SCD) and HIV using gene-based treatments. (nih.gov)
Educate yourself about treatments and transplants as soon as possible. (cancer.org)

These primary cell cultures were often noted to spontaneously degenerate over time, and adenoviruses are now known to be a common cause of asymptomatic respiratory tract infection that produces in vitro cytolysis in these tissues. (medscape.com)
1, 2, 3] Adenoviruses can infect various cells, both proliferating and quiescent, and thus hold the promise of targeting many different tissues and diseased cell lines. (medscape.com)
Organ donation takes healthy organs and tissues from one person for transplantation into another. (longlifehealthy.com)
The unexpected plasticity of adult stem cells has made it possible to use this type of undifferentiated, self-renewing cell successfully for the healing of various human tissues and organs, 1 particularly in hearts damaged after myocardial infarction. (lifeissues.net)
Overview of Transplantation Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. (msdmanuals.com)
Researchers hope to use stem cells to repair or replace cells or tissues damaged or destroyed by such disorders as Parkinson disease, diabetes, and spinal injuries. (msdmanuals.com)

Antiretroviral therapy, the most common treatment for patients with HIV, has been shown to restore CD4+ T cell counts. (wikipedia.org)
Their stem cells are more likely to help patients than stem cells from older people. (medlineplus.gov)
Some types of fungal infections are more common than others in stem cell transplant patients. (cdc.gov)
Aspergillosis is the most common type of fungal infection in stem cell transplant patients, followed by Candida infection and mucormycosis, but other types of fungal infections are also possible. (cdc.gov)
Scientists are still learning about which transplant patients are at highest risk and how to best prevent fungal infections. (cdc.gov)
The first bone marrow stem cell transplantations for child patients were carried out in the late 1960s in the United States. (helsinki.fi)
Together with my group, I have taken part in developing stem cell therapies specifically for child patients. (helsinki.fi)
5 Moreover, embryonic stem cells have caused tumors in animal models 6 and might seed cancer if administered to human patients. (lifeissues.net)
However, the use of cloned embryonic stem cells entails a high risk of introducing cells from abnormal embryos into patients. (lifeissues.net)
this should lead to better overall survival in both transplant and non-transplant patients. (medscape.com)

The new blood stem cells will rebuild your body's blood and immune systems. (leukaemia.org.au)
The researchers found that blood stem cells, which are among the smallest cells in the body, lose their ability to perform their normal function -- replenishing the body's blood cells -- as they grow larger. (sciencedaily.com)

are likely to become infected because they have human immunodeficiency virus ( HIV ) or cancer or have had a transplant operation (surgery to remove an organ and replace it with a donor or artificial organ). (nih.gov)
No evidence of serious organ dysfunction based upon the transplanting institution's evaluation. (aetna.com)

Current research in Stem Cell Transplantation (SCT) focuses on improving transplant outcome through immune manipulations using cell therapy and lymphocyte growth factors. (nih.gov)
Of interest is the role of adenoviruses as viral vectors in vaccination and in gene therapy.For example, in viral vector vaccines against SARS-CoV2, the vector virus is used to deliver RNA encoding SARS-CoV2 spike protein into target cells. (medscape.com)
According to Kim Vettenranta , professor of cell therapy and blood transfusion medicine at the University of Helsinki, the prognosis for ALL is these days relatively good. (helsinki.fi)
In this therapy, T cells are extracted from the patient, after which they are modified by employing gene technology to identify malignant leukaemia cells. (helsinki.fi)
As such, the principle of targeted cell therapy has been known for approximately 30 years. (helsinki.fi)
At the New Children's Hospital, the first child patient suffering from leukaemia has already been treated with this targeted cell therapy. (helsinki.fi)
For the next five years, I aim to introduce what is known as version 2.0 of cancer cell therapy in Finland, much like Martti Siimes in his time brought us version 1.0 in the 1970s, only at that time in terms of bone marrow transplants. (helsinki.fi)

and secondly, "embryonic" stem cells, which are obtained by the disaggregation of human embryos. (lifeissues.net)
3. By contrast, research using human embryonic stem cells has been hampered by important technical difficulties. (lifeissues.net)
Embryonic stem-cell experiments have not yet produced a single unqualified therapeutic success, not even in animal models. (lifeissues.net)
Unless these grave hazards are removed, embryonic stem-cell experiments would not have any clinical application. (lifeissues.net)
9 Embryonic stem cells harvested from abnormal and unfit embryos will carry their "epigenetic defects" and transmit at least part of them to their daughter cells. (lifeissues.net)
The transfer of such cloned embryonic stem cells into a patient would be therefore extremely hazardous: these cells might provoke genetic disorders, or initiate leukemias or other cancers. (lifeissues.net)

A donor stem cell transplant aims to replace bone marrow that is no longer working properly with healthy stem cells from another person (a donor). (macmillan.org.uk)
The basic idea of bone marrow transplantation used in treating leukaemia has remained unchanged to this day: healthy stem cells are extracted from a healthy donor and transplanted into a leukaemia patient after conditioning. (helsinki.fi)

A lung transplant removes a person's diseased lung and replaces it with a healthy one. (longlifehealthy.com)
Some people get one lung during a transplant. (longlifehealthy.com)

Aetna considers allogeneic hematopoietic cell transplantation medically necessary for the treatment of persons with relapsed NHL (including persons who have relapsed after autologous hematopoietic cell transplantation) or primary refractory (see "Note" below) NHL (low-grade, intermediate-grade, and high-grade) if the person meets the transplanting institution's protocol eligibility criteria. (aetna.com)

Experiments show that transplantation of other types of veto cells along with megadose haploidentical HSCT allows to reduce the toxicity of the conditioning regimen, which makes this treatment much safer and more applicable to many diseases. (wikipedia.org)
Grafts can be made more tolerant by treatment with low doses of a lymphocyte growth factor called interleukin-2 (IL-2), and Dr. Barrett's group has used IL-2 to mitigate otherwise dangerous GVH reactions in a transplant protocol where the donor is a half-matched family member. (nih.gov)
The high-dose treatment destroys the cancer cells, but it also affects your healthy blood cells. (macmillan.org.uk)
After the high-dose treatment, you are given your stem cells back through a drip (infusion). (macmillan.org.uk)
An autologous stem cell transplant is a complex treatment. (macmillan.org.uk)
For HIV, an effective gene-based treatment would safely modify selected cells to stop the virus from replicating, eliminate it from the body, and prevent re-infection. (nih.gov)
In short, a stem cell transplant is necessary to ensure that the bone marrow is repopulated with healthy blood stem cells following high-dose treatment. (leukaemia.org.au)
After the treatment, the researchers measured the functionality of these two groups of stem cells by injecting them into mice that had their own blood stem cells eliminated. (sciencedaily.com)
When faux death is achieved, they start replacing cells from the ones harvested from her hip before the treatment. (rdhmag.com)
Aetna considers non-myeloablative allogeneic hematopoietic cell transplantation medically necessary ("mini-transplant", reduced intensity conditioning transplant) for the treatment of persons with relapsed NHL (including persons who have relapsed after ABMT) or primary refractory (see note below) NHL (low-grade, intermediate-grade, and high-grade) when they are eligible for conventional allografting or a reduced intensity regimen is preferred by the transplant center. (aetna.com)

Bone marrow donation can be done either by collecting a donor's bone marrow surgically, or by removing stem cells from a donor's blood. (medlineplus.gov)
Then, a counselor meets with the donor to discuss the bone marrow donation process. (medlineplus.gov)

The European Society for Blood and Bone Marrow Transplantation: Hematopoietic stem cell transplantation and cellular therapies. (macmillan.org.uk)
This raises the question of whether cell size is important for cellular physiology. (sciencedaily.com)
The new study suggests that cellular enlargement drives a decline in function of stem cells. (sciencedaily.com)
Thereafter, adenovirus produces potent E1A proteins that immortalize primary rodent cells by altering cellular transcription, ultimately leading to deregulation of apoptosis and malignant transformation. (medscape.com)

2 The multiple therapeutic achievements that have been demonstrated using adult stem cells, and the promise they hold for other diseases, such as neurodegenerative disorders or diabetes, make efforts to support this fruitful avenue of investigation an urgent matter. (lifeissues.net)

Serotype-specific clinical manifestations may be partially determined by differences in cell tropism. (medscape.com)
Others are already partially differentiated and can only become, for example, some kinds of nerve cell. (msdmanuals.com)

There are two main types of white blood cell. (macmillan.org.uk)
There are two main types of transplants: autologous transplants and allogeneic transplants. (leukaemia.org.au)
Cells of the same type are strikingly uniform in size, while cell size differs between different cell types. (sciencedaily.com)
Stem cells are cells with the potential to develop into many different types of cells in the body. (longlifehealthy.com)
Stem cells are undifferentiated cells that have the potential to become one of 200 types of cells in the body, including blood, nerve, muscle, heart, glandular, and skin cells. (msdmanuals.com)
These stem cells can produce different types of blood cells. (msdmanuals.com)

When the blood cells are fully developed, they go into the bloodstream. (macmillan.org.uk)

The collaboration will align aggressive, high-reward research efforts to accelerate progress on shared gene-based strategies (depicted in green) to cure sickle cell disease and HIV that are available globally including in low-resource settings, while continuing to invest in other parallel research efforts on cures for these two diseases outside of the collaboration. (nih.gov)
Mutations in the gene for beta globin, a component of hemoglobin, cause red blood cells to become hard, sticky, and misshapen in the form of a C-shaped "sickle. (nih.gov)
Sickle cells die early, causing a constant shortage of red blood cells, and can clog blood flow, resulting in pain and other serious problems. (nih.gov)
Recipients are individuals at least 18 years of age who have been diagnosed with sickle cell disease and Beta-thalassemia, and who have a family member who is a haploidentical (i.e., half match) tissue match. (nih.gov)

This destroys the faulty stem cells in your bone marrow. (longlifehealthy.com)

Bone marrow and blood stem cell transplantation (commonly referred to as simply stem cell transplantation) is used to treat a range of diseases. (leukaemia.org.au)

Stem cell transplantation is the removal of stem cells (undifferentiated cells) from a healthy person and their injection into someone who has a serious blood disorder. (msdmanuals.com)

Recipients will undergo routine physical and laboratory examinations, including bone marrow sampling at the beginning of the study. (nih.gov)

One example is antigen-specific CD4+ T cell tolerance, which serves as the primary mechanism restricting immunotherapeutic responses to the endogenous self antigen guanylyl cyclase c (GUCY2C) in colorectal cancer. (wikipedia.org)
However, in some cases, selective CD4+ T cell tolerance provides a unique therapeutic opportunity to maximize self antigen-targeted immune and antitumor responses without inducing autoimmunity by incorporating self antigen-independent CD4+ T cell epitopes into cancer vaccines. (wikipedia.org)
remove any remaining cancer cells from your body. (macmillan.org.uk)
Cancer cells frequently acquire abnormalities in the same chromatin regulatory pathways, which promote malignancy and may impart targetable therapeutic dependencies 2 . (nature.com)
Suicide gene systems that convert nontoxic systemically delivered prodrugs to active chemotherapeutic agents have been delivered via adenoviral vectors directly into cancer cells. (medscape.com)
The main reason is that the cancer cells are not clustered together in a single, removable tumor, but rather usually spread widely throughout the body as the blood circulates, making surgical removal virtually impossible. (moffitt.org)
A stem cell transplant is a valiant effort to kill all cancer cells, inadvertently killing all cells in the human body. (rdhmag.com)
Essentially, a stem cell transplant brings the person to the fringe of death then brings them back to life at the last possible moment with non-cancer cells harvested from the hip-bone of the cancer host before the poisoning. (rdhmag.com)

Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. (nih.gov)

Many scientists believed that this enlargement was simply a side effect of aging, but the Amon lab began to investigate the possibility that large cell size drives age-related losses of function. (sciencedaily.com)
Scientists are developing ways of enabling (inducing) other cells (such as a blood or skin cell) to act as stem cells. (msdmanuals.com)

Bone marrow harvest. (medlineplus.gov)
After a bone marrow harvest, the donor stays in the hospital until they're fully awake and can eat and drink. (medlineplus.gov)
The Holy See opposes the cloning of human embryos for the purpose of destroying them in order to harvest their stem cells, even for a noble purpose, because it is inconsistent with the ground and motive of human biomedical research, that is, respect for the dignity of human beings. (lifeissues.net)

8 Technical problems aside, the need to extract these cells from living human embryos raises ethical questions of the highest order. (lifeissues.net)
Stem cells can be obtained from the embryos that are not used. (msdmanuals.com)
Because the embryos then lose the ability to grow into a complete human being, the use of stem cells from embryos is controversial. (msdmanuals.com)

To study how size affects these stem cells, the researchers damaged their DNA, leading to an increase in their size. (sciencedaily.com)
One way to induce these cells is to inject them with material that affects their genes, a process called reprogramming. (msdmanuals.com)

Sometimes stem cells also need to be replaced because they are diseased (for example in leukaemia) or defective (for example in aplastic anaemia ). (leukaemia.org.au)

These veto cells can also exert graft vs tumor effect. (wikipedia.org)

Anatomy31

Organisms14

Diseases61

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment72

Psychiatry and Psychology2

Phenomena and Processes36

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

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Health Care17

Autologous transplant4

Type of transplant4

Chemotherapy8

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Hematopoietic stem3

Called an allogeneic1

Allogeneic transplant1

Help the blood to clot1

Donors5

Procedure3

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Peripheral2

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Patient's3

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Lymphoma6

Immune system9

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Allogenic3

Risks3

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Needs a transplant1

Collected from a donor1

Rejection5

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Doctors2

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Destroy1

GVHD2

Treatments2

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Organ2

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Cancer8

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Scientists2

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Tumor1