Cells released significantly. Medical search. Frequent questions

Activity of VEGF-A, as its name implies, has been studied mostly on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g., stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells). (wikipedia.org)
Endometrium-derived epithelial cells (Ishikawa) showed no response to the natural compound by using a cell viability assay (MTT). (nutrimedical.com)
Quercetin glycosides from diet are slightly absorbed via the intestinal epithelial cells, although most of them return into the digestive tract by the action of specific transporter systems. (rsc.org)
Phase II enzymes present in the intestinal epithelial cells and the liver cells facilitate their metabolic conversion to glucuronide and sulfate conjugates. (rsc.org)
Primary human bronchial epithelial cells, fibroblasts and monocyte-derived macrophages were exposed to EVs isolated from swine CAFO dust. (cdc.gov)
Based on our results, we hypothesize about the existence of mechanisms of resistance that could prevent the trafficking of T effector cells into the epithelial component of the tumor as a potential explanation for the lack of efficacy of ICI in the first line of advanced EOC. (bvsalud.org)

miRNAs have been implicated as transcriptional regulators in a wide range of biological processes determining cell fate, stress response, proliferation, or death [ 5 ]. (hindawi.com)
For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
Melatonin significantly enhanced the epirubicin-induced cell proliferation suppression, epirubicin-induced apoptosis, and reduced the IC50 value of epirubicin. (greenmedinfo.com)
PKC is an important signaling molecule in numerous cell pathways, including cell differentiation, proliferation and apoptosis. (medscape.com)

By releasing DMOG from mesenchymal stem cell (MSC) laden alginate hydrogels, it is possible to stabilize HIF-1α and enhance its nuclear localization. (amrita.edu)
mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. (springer.com)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)

We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
These results indicate that limited membrane permeabilization occurs in blebs and apoptotic bodies before secondary necrosis, leading to acute and localized release of immunomodulatory proteins during the early phase of active apoptotic membrane blebbing. (nature.com)
Therefore, the shift from apoptosis to secondary necrosis is more graded than a simple binary switch, with the membrane permeabilization of apoptotic bodies and consequent limited release of DAMPs contributing to the transition between these states. (nature.com)
2 , 3 A key feature of apoptosis has been defined as the maintenance of an intact cellular membrane (detectable as exclusion of impermeable dyes such as propidium iodide, PI) throughout the apoptotic program to prevent intracellular protein release and subsequent immunological activation. (nature.com)
In addition to maintenance of membrane integrity, apoptotic cells can be discriminated from viable counterparts based on several morphological hallmarks, including cell contraction, nuclear condensation and fragmentation, and actomyosin contraction-dependent membrane blebbing and apoptotic body formation. (nature.com)
But while this degradation to the cell membrane does occur, it is not significant within the ten-minute window and there is no solution leakage. (eurekalert.org)
So, overall, this is a great way to learn about cell membrane molecules in their native state in high resolution. (eurekalert.org)
In the present study, we examined potential contributory roles of membrane-associated, cholesterol-enriched lipid rafts/caveolae and their constituent proteins (e.g., caveolin-1 [Cav-1]) as potential sites for IL-1β−induced nitric oxide (NO) release in the isolated β-cell. (diabetesjournals.org)
Here we provide the first evidence to suggest that tyrosine phosphorylation of Cav-1 and subsequent interaction among members of the Ras signaling pathway within the membrane lipid microdomains represent early signaling mechanisms of IL-1β in β-cells. (diabetesjournals.org)
Nearly all cells secrete membrane-bound vesicles (extracellular vesicles, EVs) that have the capacity to transmit protein, nucleic acid, and lipid signaling mediators between cells. (cdc.gov)
Drug release assays showed that Met exhibited sustained release after encapsulation by the macrophage cell membrane. (bvsalud.org)
A study by White et al (2009) found that psychosine's cytotoxic effects on oligodendroglia and Schwann cells was mediated through disruption of the architecture and composition of lipid rafts (cell membrane regions characterized by high cholesterol and sphingolipid concentration), followed by altered protein kinase C (PKC) function. (medscape.com)
Importantly, we observed that loss of N-myristoylation resulted in greatly reduced infectivity of assembled mature virus particles, characterized by significantly reduced host cell entry and a decline in membrane fusion activity of progeny virus. (cdc.gov)

These signals are intensified by cytokines, significantly increasing the recruitment and activation of T cells. (nature.com)
It is well established that inflammatory cytokines such as interleukin-1β (IL-1β) play a major regulatory role in the selective destruction of insulin-producing β-cells, resulting in the onset of type 1 diabetes ( 1 - 3 ). (diabetesjournals.org)
The present study also examined the expression of various inflammatory cytokines, MAPK and NF‑κB in TNF‑α/IFN‑γ‑stimulated HaCaT cells. (spandidos-publications.com)
SNL significantly reduced the levels of cytokines released from HaCaT cells stimulated with TNF‑α/IFN‑γ. (spandidos-publications.com)
Blocking antibodies against IFN-Î³ and TGF-ß were used in vitro to prove a role for these cytokines in CCL18-T-cell-adipocyte lipolysis regulation axis. (bvsalud.org)

Blebbing, apoptotic body formation and protein release during early apoptosis are dependent on ROCK and myosin ATPase activity to drive actomyosin contraction. (nature.com)
Apoptosis allows for efficient and immunologically silent removal of damaged or superfluous cells in multicellular organisms. (nature.com)
The results indicated that TFs significantly alleviate H/R injury, which include inhibiting apoptosis and enhancing antioxidant capacity. (hindawi.com)
Our study suggests that TFs can decrease cell apoptosis, which may be mediated by altering the expression of miR-21, PTEN/Akt, and Bcl/Bax. (hindawi.com)
In murine cardiomyocytes miR-21 was found to protect from hypoxia/reoxygenation (H/R)-induced cell apoptosis via regulation of its target gene PDCD4 [ 13 ]. (hindawi.com)
CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
The cell viability and apoptosis were determined by CCK-8 assay and acridine orange/ethidium bromide (AO/EB) fluorescence staining assay. (greenmedinfo.com)
Further, melatonin synergized with epirubicin to promote the activation of the mitochondria-mediated apoptosis pathway and increased the accumulation of epirubicin in DLBCL cells by inhibiting the expression and function of P-gp. (greenmedinfo.com)
PKC isozymes are LR-dependent molecules that link psychosine-induced LR disruption to reduced PKC function and altered cell signaling activity, possibly driving demyelination and apoptosis in oligodendrocytes and Schwann cells. (medscape.com)

As a first-line treatment of inter-mediate- or high-risk diffuse large B-cell lymphoma, the addition of the antibody-drug conjugate polatuzumab vedotin-piiq to standard-of-care therapy resulted in a 27% reduction in the relative risk of disease progression, relapse, or death, with a similar safety profile. (ascopost.com)
These results support the use of polatuzumab vedotin [plus standard therapy] in the initial management of patients with diffuse large B-cell lymphoma," Dr. Salles said. (ascopost.com)
The international double-blind placebo-controlled phase III POLARIX trial evaluated a novel regimen combining the CD79b-targeting antibody-drug conjugate polatuzumab vedotin with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) in adults with newly diagnosed diffuse large B-cell lymphoma. (ascopost.com)
POLARIX enrolled a total of 879 patients with previously untreated diffuse large B-cell lymphoma and International Prognostic Index (IPI) of between 2 and 5.Baseline characteristics were well balanced between the arms. (ascopost.com)
Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin. (greenmedinfo.com)
Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway. (greenmedinfo.com)
Epirubicin is a first-line chemotherapeutic drug for the clinical treatment of diffuse large B cell lymphoma (DLBCL), but the overexpression of multidrug resistance (MDR) transporter proteins, especially P-glycoprotein (P-gp), renders epirubicin ineffective. (greenmedinfo.com)

In vitro, VEGF-A has been shown to stimulate endothelial cell mitogenesis and cell migration. (wikipedia.org)
Based on in vitro studies, beta-glucans act on several immune receptors including Dectin-1, complement receptor (CR3) and TLR-2/6 and trigger a group of immune cells including macrophages, neutrophils, monocytes, natural killer cells and dendritic cells. (nih.gov)
Since then, Attana has developed proprietary label free biosensors for biochemical, crude, sera, and cell-based assays and the Attana Virus Analytics (AVA) platform, a proprietary in vitro diagnostics (IVD) tool. (cision.com)
By stimulating hair cells with sinusoidal voltage commands that mimic pure sound tones, we recapitulated the phase-locking of hair cell exocytosis with an in vitro approach. (jneurosci.org)
a partial map of receptors on human mast cells cultured in vitro. (spandidos-publications.com)
Human T cell line (Jurkat T cells) was stimulated by rCCL18, and conditioned media (CM) was added to the in vitro cultures of human adipocytes. (bvsalud.org)

Cell surface sensors on immune cells that ordinarily recognize pathogen-associated molecular patterns produced by infectious agents may also interact with DAMPs, leading to the activation of signaling pathways resulting in a nonpathogen-induced 'sterile' inflammatory response. (nature.com)
Immune cell responses induced by DAMPs may include cytokine and chemokine release to activate inflammatory cells such as neutrophils and macrophages. (nature.com)
Aiding the immune response in the fight against cancer, TILT Biotherapeutics is developing armed oncolytic viruses that replicate in cancer cells making them more discoverable by T cells and other immunotherapies. (nature.com)
Successfully translating this discovery, the company's therapeutic approach revolves around the use of armed oncolytic adenoviruses that replicate only in cancer cells and, when they do so, modify the tumor microenvironment, restoring the ability of the immune system to eliminate aberrant cells. (nature.com)
Our oncolytic viruses better enable T cells to search out and destroy cancer cells of all tumor types, as the immune system inherently adapts to fight potential hazards. (nature.com)
In addition to their natural interaction with T cells-a predominant part of the immune system in clearing potential threats-they can be manufactured at high-titer as homogeneous drug batches, are more stable than RNA viruses, and are easy to store. (nature.com)
Our armed adenovirus is uniquely designed to make silent tumors visible to the immune system, enabling T cell therapies and checkpoint inhibitors to work," said Akseli Hemminki. (nature.com)
beta-glucans are ubiquitously found in both bacterial or fungal cell walls and have been implicated in the initiation of anti-microbial immune response. (nih.gov)
The small beta-glucans fragments are eventually released by the macrophages and taken up by other immune cells leading to various immune responses. (nih.gov)
However, beta-glucans of different sizes and branching patterns may have significantly variable immune potency. (nih.gov)
Obesity creates inflammation mediated by immune cells within fat tissue that alters insulin pathway functioning. (sdgln.com)
The present results suggest that the CNS innate immune system can respond to an acute stressor as if it were cellular damage, thereby releasing the danger signal HMGB-1 in the brain to prime microglia by acting on the NLRP3 inflammasome, in preparation for a later immune challenge. (jneurosci.org)
High-dimensional systemic immune profiling is performed in a cohort of non-small-cell lung cancer patients undergoing PD-L1/PD-1 blockade immunotherapy. (bvsalud.org)
High-throughput profiling of soluble factors in plasma identifies fractalkine (FKN), a chemokine involved in immune chemotaxis and adhesion, as a biomarker of response to immunotherapy that also correlates with myeloid cell diversity in human patients and murine models. (bvsalud.org)
Secreted FKN inhibits lung adenocarcinoma growth in vivo through a prominent contribution of systemic effector NK cells and increased tumor immune infiltration. (bvsalud.org)
In addition, 13-color flow cytometry profiling was employed to phenotype the immune cells. (bvsalud.org)

They are internalized and fragmented within the cells, then transported by the macrophages to the marrow and endothelial reticular system. (nih.gov)
This accumulation causes formation of globoid cells (hematogenous often-multinucleated macrophages containing undigested galactosylceramide), which is the histologic hallmark of Krabbe disease. (medscape.com)

In addition, inclusion or exclusion of exons 6 and 7 mediate interactions with heparan sulfate proteoglycans (HSPGs) and neuropilin co-receptors on the cell surface, enhancing their ability to bind and activate the VEGF receptors (VEGFRs). (wikipedia.org)
All members of the VEGF family stimulate cellular responses by binding to tyrosine kinase receptors (the VEGFRs) on the cell surface, causing them to dimerize and become activated through transphosphorylation, although to different sites, times, and extents. (wikipedia.org)
scTHI is an R package to identify active pairs of ligand-receptors from single cells in order to study,among others, tumor-host interactions. (bioconductor.org)
The aim of the present study was to examine the effect of the synthetic endocannabinoid (eCB) analogue, arachidonyl-2′-chloroethylamide (ACEA), on calcitonin gene-related peptide (CGRP) release in the dura and trigeminal ganglion (TG), as cannabinoids are known to activate G i/o -coupled cannabinoid receptors type 1 (CB1), resulting in neuronal inhibition. (lu.se)
Mice genetically engineered to lack these D5 receptors showed significantly reduced pain responses -- but only the males. (eurekalert.org)
Furthermore, mast cells and H1 receptors have not been the primary sites of antipruritic action of this extract. (researchgate.net)

Conclusions: Results from the present study indicate that ACEA per se does not exhibit antimigraine potential due to its dual agonistic properties, resulting in activation of both CB1 and TRPV1, and thereby inhibition and stimulation of CGRP release, respectively. (lu.se)
Furthermore, we found that both the basal Ca 2+ level and the Ca 2+ rise during sinusoidal stimulation were significantly increased by inhibition of PMCA, MCU, or SERCA. (jneurosci.org)
The exposure of C. neoformans cells or preformed cryptococcal biofilms to fluconazole or voriconazole did not result in yeast growth inhibition and did not affect the metabolic activities of the biofilms, respectively. (who.int)
Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry. (cdc.gov)

DHA-rich PUFA ratios inhibited DE-derived EV-induced proinflammatory cytokine release dose-dependently. (cdc.gov)
Mild cytokine release syndrome occurred in two patients receiving teplizumab and resolved within 7 days. (medscape.com)

Disruption of lipid rafts (e.g., with cyclodextrin) markedly reduced IL-1β−induced gene expression of inducible NO synthase (iNOS) and NO release from β-cells. (diabetesjournals.org)

The role of forensics is assumed by the dendritic cells. (uni-bonn.de)

In vivo, DMOG delivery significantly reduced mineralisation of the proteoglycan-rich cartilaginous tissue generated by MSCs within alginate hydrogels loaded with TGF-β3 and BMP-2. (amrita.edu)
3) In an attempt to study calcium dynamics in nerve cells in an intact, in vivo, preparation the calcium indicator dye calcium-green dextran was injected into one of the blastomeres of a 2 to 3 hour old zebra fish embryo which was then allowed to develop further. (bl.uk)
In particular, sound-evoked spikes in auditory afferent fibers in vivo are phase-locked to sound frequencies up to 5 kHz, but it is not clear how hair cells can handle intracellular Ca 2+ changes with such high speed and efficiency. (jneurosci.org)
Exposure to 100 inescapable tail shocks (ISs) increased HMGB-1 and NLRP3 protein in the hippocampus and led isolated microglia to release HMGB-1 ex vivo . (jneurosci.org)

Charité researchers have discovered that the use of SKP2 inhibitors can significantly reduce viral replication. (charite.de)
To cristata ) that were found in the field and suspected of screen for WNV, cell culture bottles showing viral CPE being WNV infected. (cdc.gov)
A few days after a viral infection, countless killer cells swarm out to track down and kill infected body cells. (uni-bonn.de)
We have recently shown that the replication of rhinovirus, poliovirus and foot-and-mouth disease virus requires the co-translational N-myristoylation of viral proteins by human host cell N-myristoyltransferases (NMTs), and is inhibited by treatment with IMP-1088, an ultrapotent small molecule NMT inhibitor. (cdc.gov)

CGRP release was induced by either 60 mM K + (for depolarization-induced stimulation) or 100 nM capsaicin (for transient receptor potential vanilloid 1 (TRPV1) -induced stimulation) and measured using an enzyme-linked immunosorbent assay. (lu.se)
Without stimulation, 140 nM ACEA per se caused a significant increase in CGRP release in the dura but not TG, compared to vehicle. (lu.se)
Recent work studies the effect of electrical stimulation on neural stem cells seeded on the conductive scaffold and the pathways by which it enhances stroke recovery Further understanding the combined effect of electrical stimulation and stem cells in augmenting neural repair for clinical translational is a major focus of this research going forward. (stanford.edu)
Immunologic and confocal microscopic evidence also suggested a transient but significant stimulation of tyrosine phosphorylation of Cav-1 in β-cells briefly (for 15 min) exposed to IL-1β that was markedly attenuated by three structurally distinct inhibitors of protein tyrosine phosphorylation. (diabetesjournals.org)
However, previous studies of Ca 2+ handling in auditory hair cells have often been conducted in immature hair cells, with elevated extracellular Ca 2+ concentration, or through steady-state stimulation that may not be physiologically relevant. (jneurosci.org)

Hypoxia is a known regulator of stem cell fate, the effects of which can be mimicked using hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors such as dimethyloxalylglycine (DMOG). (amrita.edu)
Our previous study revealed that hypoxia preconditioning of H9c2 cardiomyocytes significantly increased the de novo synthesis of DJ-1 and induced cardioprotection against prolonged hypoxic injury 24 h later ( 17 ). (spandidos-publications.com)

In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
The acute transient neurotoxicity observed in rats exposed to MeI is best supported by a mode of action involv- ing modification of ion currents by the parent chemical in nerve cells. (cdc.gov)

Dying cells have been defined as apoptotic by distinguishing features, including cell contraction, nuclear fragmentation, blebbing, apoptotic body formation and maintenance of intact cellular membranes to prevent massive protein release and consequent inflammation. (nature.com)
The analysis of CGRP release data was combined with immunohistochemistry in order to study the cellular localization of CB1, cannabinoid receptor type 2 (CB2), CGRP and receptor activity modifying protein 1 (RAMP1), a subunit of the functional CGRP receptor, in the TG. (lu.se)
The term autophagy refers to a type of cellular recycling process which enables cells to dispose of damaged materials and waste products, while retaining intact components for incorporation into new cellular structures. (charite.de)
Subsequent observations revealed a disruption to the cellular recycling process in cells infected with the virus. (charite.de)
For this purpose, a cellular model of senescent myocardial cells was set up and evaluated using colorimetric, fluorimetric, and immunometric techniques. (hindawi.com)
Relevant cellular senescence markers, such as X-gal staining, cell cycle regulator levels, and the percentage of cell cycle-arrested cells, were found to be reduced in the presence of naringenin. (hindawi.com)
Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, together, the data have prompted us to investigate the effects of Nar in a cellular model of aged myocardial cells. (hindawi.com)
Various cellular senescence hallmarks (the percentage of X-gal staining cells, the mRNA levels of the p16 and p21 cell cycle regulators, and the percentage of cell cycle-arrested cells) were investigated. (hindawi.com)

H9c2 cells pretreated with TFs for 24h were exposed to H/R treatment. (hindawi.com)
The protective effects of TFs resulted in higher expression of miR-21 in H/R-induced H9c2 cells than that of controls, which in turn upregulated Akt signaling activity via suppressing the expression of PTEN together with decreasing the ratio of Bax/Bcl-2, caspase3, and cleaved-caspase3 expression in H/R-induced H9c2 cells. (hindawi.com)
Moreover, we have found that TFs can increase the activity of superoxide dismutase (SOD) and reduce the level of malonaldehyde (MDA) together with lactate dehydrogenase (LDH) in H9c2 cells. (hindawi.com)
To test this hypothesis, we attempted to investigate whether TFs can exert its cardioprotective effect and the effects of TFs on miR-21 in H9c2 cells. (hindawi.com)

The hormones are then stored and released directly into the systemic vasculature. (medscape.com)

The possible mechanisms of melatonin sensitize DLBCL cells to epirubicin were explored by western blotting, cytochrome C release, and pulldown assay. (greenmedinfo.com)

Fat cells release fatty acids, resistin, and other molecules that impair glucose uptake and insulin signaling. (sdgln.com)
By controlled release of drugs and molecules through biomaterials we can study the temporal effect of these neurotrophic factors on neural recovery and engineer drug delivery systems to enhance regenerative effects. (stanford.edu)

MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)

are not responsible for the accuracy of news releases posted to EurekAlert! (eurekalert.org)

A new study used it to show that feedback from individual nerve cells controls the release of dopamine, a chemical messenger involved in motivation, memory, and movement. (scitechdaily.com)
They injected some of the brain cells with Botox, a toxin that blocks nerve cells from sending chemical messages to neurons and other cells. (scitechdaily.com)
Since our Botox technique helped us solve the problem of how dopamine neurons regulate their communication, it should also enable us to uncover how other nerve cells interact with each other in the mammalian brain," says study senior author Margaret Rice, PhD. (scitechdaily.com)
Studying 18 to 24 hour old embryos, using a confocal microscope, labelled nerve cells among the daughter cells of the injected blastomere could be clearly identified according to their shape and position. (bl.uk)
When such 24 hour old embryos were dissociated and plated on culture dishes labelled nerve cells responded to a depolarisation with a fluorescence increase demonstrating that the dye was retained in the cytoplasm and still capable of reporting calcium changes. (bl.uk)

scTHI contains a set of signatures to classify cells from the tumor microenvironment. (bioconductor.org)
The killer cell thus first creates a very specific microenvironment," emphasizes Kastenmüller. (uni-bonn.de)

Led by researchers at NYU Grossman School of Medicine, the new study showed that dopamine-releasing brain cells respond to their own signals to regulate the hormone's output. (scitechdaily.com)
The benefit was less clear in patients aged 60 or younger, those with lower IPI scores, patients with bulky disease, and those who had the germinal-center B-cell-like subtype, the study showed. (ascopost.com)
A study showed that ganoderic acids C and D isolated from G. lucidum inhibit the release of histamine from mast cells [81] . (researchgate.net)
Their study showed that TNF-alpha -1031*C, -863*A, -857*C, and -308*G alleles were significantly associated with Behçet disease. (medscape.com)

Hormones are natural chemicals produced in one location, released into the bloodstream, and then used by other target organs and systems. (medlineplus.gov)
Often referred to as the "master gland", the pituitary gland synthesizes and releases various hormones that affect several organs throughout the body (see the images below). (medscape.com)
The release of these pituitary hormones is mediated by hypothalamic neurohormones that are secreted from the median eminence (a site where axon terminals emanate from the hypothalamus) and that reach the adenohypophysis via a portal venous system. (medscape.com)
These hypothalamic cell bodies produce hormones that undergo axonal transport through the pituitary stalk and into terminal axons within the neurohypophysis. (medscape.com)

Using these new insights, the researchers treated MERS-infected cells with various SKP2 inhibitors in order to stimulate the degradation process. (charite.de)

To answer this question, we first investigated the ability of ellagic acid to influence the activity of the estrogen receptor subtypes ERalpha and ERbeta in HeLa cells. (nutrimedical.com)

We identified 231 proteins released from actomyosin contraction-dependent blebs and apoptotic bodies by adapted SILAC (stable isotope labeling with amino acids in cell culture) combined with mass spectrometry analysis. (nature.com)
10 9 apoptotic events occurring per day in human adult tissues, it is surprisingly difficult to histologically detect apoptotic cells due to the rapid recognition and clearance of apoptotic cells. (nature.com)

The MeOH extract of Ganoderma lucidum has an inhibitory action on histamine release from rat mast cells. (researchgate.net)
Ganoderic acids C and D were shown to inhibit histamine release from rat mast cells. (researchgate.net)
The skin tissue was sectioned to measure the thicknesses of the epidermis and dermis, as well as the numbers of eosinophils, mast cells and CD8 infiltration by H&E, toluidine blue, Masson's trichrome and IHC staining. (spandidos-publications.com)
In addition, SNL significantly reduced the level of serum IgE and dermal thickness and the infiltration of mast cells and CD8 in the BALB/c mouse model of DNCB‑induced AD. (spandidos-publications.com)
Kraneveld AD, Sagar S, Garssen J and Folkerts G: The two faces of mast cells in food allergy and allergic asthma: The possible concept of Yin Yang. (spandidos-publications.com)

DJ‑1 protein, as a multifunctional intracellular protein, has been demonstrated to serve a critical role in regulating cell survival and oxidative stress. (spandidos-publications.com)
Lactate dehydrogenase (LDH) and creatine kinase‑MB (CK‑MB) release, infarct size, cardiac function, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities, malondialdehyde (MDA), intracellular reactive oxygen species (ROS), and DJ‑1 protein expression levels were assessed. (spandidos-publications.com)

Recent work utilizing these novel conductive polymers to differentiate stem cells for therapeutic and drug discovery applications. (stanford.edu)
Controlling the phenotype of transplanted stem cells is integral to ensuring their therapeutic efficacy. (amrita.edu)
If not that, we may need to develop diagnostics to look at an individual's cell types that are prolonging pain, so we can tailor the therapeutic based on the underlying mechanism. (eurekalert.org)

Diabetes involves abnormal blood sugar regulation stemming from inadequate insulin secretion by the pancreas or improper insulin utilization in the body's cells. (sdgln.com)
Images from a special microscope show for the first time how specialized cells of the body's defenses then head towards it. (uni-bonn.de)

First, for one cell to control its neighbor with dopamine, a large number of synapses, or junctions where two cells meet and exchange messages, would be required. (scitechdaily.com)
In this study, we combined patch-clamp recording and two-photon Ca 2+ imaging to examine Ca 2+ dynamics in hair cell ribbon synapses in the bullfrog amphibian papilla of both sexes. (jneurosci.org)
SIGNIFICANCE STATEMENT Hair cell synapses can transmit sound-driven signals precisely in the kHz range. (jneurosci.org)
This allowed us to reveal the Ca 2+ extrusion mechanisms that are required for phase-locking at auditory hair cell ribbon synapses. (jneurosci.org)

In addition, IPC reduced LDH and CK‑MB release, attenuated myocardial infarct size, improved cardiac function following I/R, and inhibited the elevation of ROS and MDA and the decrease in activities of the antioxidant enzymes SOD, CAT and GPx. (spandidos-publications.com)
These results suggested that naringenin has antiaging effects on myocardial cells. (hindawi.com)
The results demonstrated that Nar exerts effective antiaging properties in myocardial cells. (hindawi.com)

For older versions of R, please refer to the appropriate Bioconductor release . (bioconductor.org)

Vascular endothelial growth factor (VEGF, /vɛdʒˈɛf/), originally known as vascular permeability factor (VPF), is a signal protein produced by many cells that stimulates the formation of blood vessels. (wikipedia.org)

The FDA placed a clinical hold on Vertex's investigational diabetes cell therapy VX-880 , saying the company didn't have enough evidence to support a treatment dose increase. (medpagetoday.com)
Type 1 diabetes results from autoimmune destruction of insulin-producing beta cells. (sdgln.com)
Obesity significantly increases the risk of developing type 2 diabetes. (sdgln.com)
Just a modest weight loss of 5-10% in obese individuals can sharply reduce diabetes risk by restoring insulin sensitivity and beta cell function. (sdgln.com)
Teplizumab (Tzield) infusions in children and adolescents with new-onset type 1 diabetes met the primary endpoint of preserved beta-cell function and trended toward improved secondary glycemic endpoints. (medscape.com)
Teplizumab, a humanized monoclonal antibody to CD3 on T cells, was approved by the US Food and Drug Administration in November 2022 to delay the onset of clinical type 1 diabetes in patients aged 8 years or older with preclinical (stage 2) disease. (medscape.com)
Cite this: Teplizumab Preserves Beta Cells in New-Onset Type 1 Diabetes - Medscape - Oct 18, 2023. (medscape.com)

Such "self-regulation," the researchers say, stands in contrast to the widely held view that the release of dopamine - known as the "feel good" hormone - by any cell relied on messages from nearby cells to recognize that it is releasing too much of the hormone. (scitechdaily.com)

The most enriched proteins released were the nucleosomal histones, which have previously been identified as damage-associated molecular pattern proteins (DAMPs) that can initiate sterile inflammatory responses. (nature.com)

Studies indicate that early unrelated hematopoietic stem cell transplantation in both the infantile and late-onset forms is associated with at least short-term benefits on neurocognitive parameters, lifespan, and quality of life. (medscape.com)

The order shows a market acceptance for our technology and capability to characterize interactions with cells, tissues, viruses etc it also provides a value of our application knowledge and the advises we can provide. (cision.com)
Immunofluorescence and immunohistochemical staining were used to detect the expression of P-gp in DLBCL cells and tissues. (greenmedinfo.com)

The mechanism by which amphotericin B and caspofungin interfered with C. neoformans biofilm formation involved capsular polysaccharide release and adherence. (who.int)

Karin Lindkvist at the Department of Cell and Molecular Biology and Richard Neutze at the Department of Chemistry, University of Gothenburg have determined the three-dimensional structure of the yeast aquaporin. (expertsvar.se)
But such processes deteriorate the cells' original molecular composition and distribution. (eurekalert.org)
Researchers from Chemical Physics have successfully explained how iron-based dyes work on a molecular level in solar cells. (lu.se)

TILT was founded on the unique discovery from clinical observations that oncolytic adenoviruses potently engage T cell responses in cancer patients. (nature.com)

Plus, SK On has installed capacity to support the scaling of Ford's high-volume F-150 Lightning and E-Transits through late 2023 - scaling NCM cell production beyond earlier-planned levels from its Atlanta facility and providing new battery cell capacity from its Hungary operation. (theautochannel.com)

People with low triiodothyronine (T3) syndrome had significantly less survival time after diagnosis with multiple myeloma. (medpagetoday.com)

The intrinsic instability of the perovskite material towards air, moisture and heat is a serious concern, leading to degradation of the active layer in the solar cell devices in a matter of days. (kth.se)
It is the graphene that is expected to protect the cells from desiccation and cell membranes from degradation. (eurekalert.org)

In women, estrogen and prolactin levels often decrease significantly. (medlineplus.gov)
RESULTS: Our results showed that the addition of bevacizumab to NACT plays a role mainly on lymphoid populations at the stromal compartment, detecting a significant decrease of CD4+ T cells, an increase of CD8+ T cells and an upregulation effector/regulatory cells ratio (CD8+/CD4+FOXP3+). (bvsalud.org)

The investigators also intend to examine how self-regulation of dopamine might contribute to cell death in Parkinson's disease. (scitechdaily.com)
Calcium is thought to play a crucial role in the regulation of nerve cell development and growth cone behaviour. (bl.uk)

In the present work, we have isolated and characterized the extracellular vesicles from human AD-MSC to investigate their role in the chondroprotective actions of these cells. (karger.com)

Solar cells convert sunlight to electricity in an emission free manner, which renders them one of the most promising technologies for the future. (kth.se)
Silicon solar cells are the most common solar cell technology commercially, with relatively high efficiencies. (kth.se)
However, solar cells based on silicon are expensive. (kth.se)
Specifically, methylammonium lead triiodide (MAPbI3) represents the archetype of 3D perovskite material that has demonstrated high efficiencies as light-absorbing layers in solar cell devices. (kth.se)
In Chapter 1, an introduction to the solar cell field, and especially to the PSCs is presented. (kth.se)
The characterization, properties and application of the materials in solar cells are also discussed. (kth.se)
Properties of the compounds and their application in solar cells are presented and discussed as well. (kth.se)
The new findings will accelerate the development of inexpensive and environmentally friendly solar cells. (lu.se)
The goal is to be able to use iron-based dyes in solar cells in the future. (lu.se)
By using iron instead of other more expensive and rare metals, the production of solar cells and light hervesters will become cheaper and more environmentally friendly. (lu.se)

We use rodent models of stroke combined with biomaterial techniques, stem cell transplants, and microfabrication to achieve these aims and evaluate our methods with behavior testing and various imaging techniques. (stanford.edu)

These birds whether feather pulp or cloacal swab suspensions, negative were submitted, from August through October, as field for virus isolation, contained quantities of WNV below the cases in the course of the larger 2002 wildlife surveillance detection level of cell culture. (cdc.gov)

Our findings provide the first evidence that dopamine neurons regulate themselves in the brain," says study lead author Takuya Hikima, PhD. "Now that we better understand how these cells behave when they are healthy, we can start to unravel why they break down in neurodegenerative disorders like Parkinson's disease," adds Hikima, an instructor in the Department of Neurosurgery at NYU Langone Health. (scitechdaily.com)
Second, many types of hormone-producing cells in the body use a streamlined system that self-regulates further release, so it seemed odd that dopamine neurons would use a more roundabout process. (scitechdaily.com)
For the study, published rcently in the journal Cell Reports , the research team collected dopamine neurons from dozens of mice. (scitechdaily.com)
By injecting Botox into single neurons, says Hikima, the researchers hoped to show whether any signal to continue or stop dopamine release could only come from outside the "paralyzed" cell. (scitechdaily.com)
If the neurons were in fact controlled by neighboring dopamine cells, then dopamine release would remain unaffected because the treated cells would still receive dopamine signals from the untreated cells nearby. (scitechdaily.com)
Instead, the findings revealed a 75 percent drop in dopamine outflow, suggesting that dopamine neurons largely rely on their own discharge to determine release rate of the hormone, according to the investigators. (scitechdaily.com)

All living organisms must be able to regulate the flow of water into and out from cells, in order to maintain cell form and size. (expertsvar.se)

Monkey kidney cells infected with MERS-coronavirus (green). (charite.de)
Various laboratories have used organs such as kidney and spleen pool suspension was blended in a brain, kidney, and spleen to isolate the virus in cell culture, Stomacher 400 Circulator (Seward, Norfolk, UK) until it or to detect the virus by using a variety of techniques, or appeared homogeneous. (cdc.gov)
800 x g for 30 min at 4°C, and 1 mL of the supernatant was describe the results of WNV isolation attempts from cloa- injected onto an established Vero (ATCC CRL-1587) cell cal swabs, kidney and spleen pools, and the flight feathers monolayer in 12-cm2 (culture surface area) bottles. (cdc.gov)

Our results demonstrated that melatonin inactivates the NF-κB pathway and downregulates the expression of P-gp, ultimately sensitizing DLBCL cells to the epirubicin that suppresses their growth. (greenmedinfo.com)
Water sample results throughout the lake have cell concentrations significantly over the recommended warning threshold level," the Utah County Health Department said Wednesday in a news release. (sltrib.com)

We focus on developing conductive polymers for stem cell applications. (stanford.edu)

In 1989 Ferrara and Henzel described an identical factor in bovine pituitary follicular cells which they purified, cloned and named VEGF. (wikipedia.org)

In addition, motor function in mice was significantly improved after SeNPs-Met-MVs treatment. (bvsalud.org)
PTEN-KO mice had significantly more ß-tubulin III labeled axons within the lesion when treatment was delivered acutely, but not chronically post-SCI. (bvsalud.org)

Epithelial6

Proliferation5

Mesenchymal4

Membrane13

Cytokines5

Apoptosis9

Diffuse large B-7

Vitro6

Immune16

Macrophages2

Receptors6

Inhibition4

Cytokine2

Lipid rafts1

Dendritic cells1

Vivo4

Viral4

Stimulation5

Hypoxia2

Acute2

Cellular8

H9c24

Systemic1

Assay1

Molecules2

Adipocytes1

EurekAlert1

Nerve cells5

Microenvironment2

Study showed4

Hormones4

Inhibitors1

HeLa1

Apoptotic2

Mast cells5

Intracellular2

Therapeutic3

Body's2

Synapses4

Myocardial3

Bioconductor1

Protein1

Diabetes7

Recognize1

Inflammatory1

Hematopoietic1

Tissues2

Polysaccharide1

Molecular3

Responses1

20231

Survival1

Degradation2

Decrease2

Regulation2

Extracellular1

Solar10

Methods1

20021

Neurons6

Regulate1

Kidney3

Results2

Stem cell1

Pituitary1

Mice2