Cells receptors very late antigen. Medical search. Frequent questions

Chimeric antigen receptors (CARs) are synthetic proteins expressed on the surface of T cells. (medscape.com)
Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
Chimeric antigen receptors T (CAR-T) cell therapy of cancer is a rapidly evolving field. (duke.edu)
The T-cells are then genetically engineered to produce chimeric antigen receptors (CARs). (shebaonline.org)

Moreover, γδ T cells can directly kill target cells without the involvement of dendritic cells (DCs) and perform dual functional roles in antitumor and anti-infective immunity. (nature.com)
Follicular dendritic cells (FDC) are cells of the immune system found in primary and secondary lymph follicles (lymph nodes) of the B cell areas of the lymphoid tissue. (wikipedia.org)
Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin. (wikipedia.org)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
200 kDa C-type lectin transmembrane protein of the MMR (macrophage mannose receptor) family, expressed at high levels on dendritic cells and thymic epithelial cells, and at low levels on lymphocytes, NK cells and monocytes. (exbio.cz)
CD205 is responsible for uptake and processing of captured antigens for dendritic cells. (exbio.cz)
Expression of CD39 is found on activated lymphocytes, a subset of T cells and B cells, and dendritic cells with weak staining on monocytes and granulocytes. (biolegend.com)
Activated lymphocytes, and also on a subset of T cells, regulatory T cells, B cells, and dendritic cells. (biolegend.com)
Instillation studies with fluorescein-conjugated isothiocyanate and TDI suggested that TNF-alpha deficiency also resulted in a significant reduction in the migration of airway dendritic cells to the draining lymph nodes. (cdc.gov)
The S. sonnei rough strain invades with APCs, including human dendritic cells (DCs) and mouse macrophages. (cdc.gov)

Follicular DCs receptors CR1, CR2 and FcγRIIb trap antigen opsonized by complement or antibodies. (wikipedia.org)
Traditional polyclonal and monoclonal antibodies are the product of normal B cell development and genetic recombination. (cellsignal.com)
While polyclonal antibodies are secreted by many different B cell clones and recognize multiple antigenic epitopes, monoclonals originate from a single B cell clone and are specific for just one epitope. (cellsignal.com)
Where polyclonal antibodies are purified directly from the serum of the immunized host, and monoclonals are purified from either hybridoma-derived tissue culture supernatant or ascites, recombinant antibodies are instead purified from the tissue culture supernatants of transfected host cell lines. (cellsignal.com)
Chinese hamster ovary (CHO) cells have been used in biomanufacturing for decades because of their robust capacity to express a range of proteins, such as therapeutic enzymes and monoclonal antibodies (MAbs) at titers measured in multiple grams per liter of culture. (bioprocessintl.com)
Antibodies can be produced by bone marrow plasma cells, which in some cases will keep producing antibodies for decades. (sciforums.com)
I am doubting, how these long kived cells go on producing antibodies without antigens? (sciforums.com)
Effector B cells can begin secreting antibody while they are still small lymphocytes, but the end stage of their maturation pathway is a large plasma cell … which continuously secretes antibodies at the astonishing rate of about 2000 molecules per second. (sciforums.com)
Antibodies are proteins made and released by B cells against foreign pathogens. (differencebetween.net)
The helper T cells stimulate B cells to release antibodies, and also trigger the activity of macrophages, which literally consume foreign pathogens. (differencebetween.net)
T cells are related to antibodies in helping in the cellular immune response. (differencebetween.net)
Antibodies are chemicals that are formed and released by B cells of the body. (differencebetween.net)
These lymphocytes are closely related to the T cells since they also originate in the bone marrow from stem cells and some of the T cells work in conjunction with B cells by triggering the release of antibodies during an immune response. (differencebetween.net)
Antibodies are chemicals that are formed and released from specific B cells in response to a signal from a T cell. (differencebetween.net)
The function of antibodies is to attach to antigens of pathogens, but some can also inhibit movement of pathogens, or paralyze or inhibit protein synthesis in viruses. (differencebetween.net)
T cells and antibodies are related in that certain T cells trigger the release of antibodies from B cells. (differencebetween.net)
This peptide-MHC complex IRAK inhibitor 3 is then recognized by CD4+ helper T cells, which stimulate the B cell to secrete antibodies (Abs). (findadig.com)
Also, serum antibodies recognized in these people show restricted ability to opsonise epitomized bacterial antigens. (alliedacademies.org)
Herein we used a single bicistronic lentiviral vector to develop a new combination immunotherapy that consists of human anti-carbonic anhydrase IX (CAIX)-targeted chimeric antigen receptor (CAR) T cells engineered to secrete human anti-programmed death ligand 1 (PD-L1) antibodies at the tumor site. (oncotarget.com)
These armed second-generation CAR T cells empowered to secrete human anti-PD-L1 antibodies in the ccRCC milieu to combat T cell exhaustion is an innovation in this field that should provide renewed potential for CAR T cell immunotherapy of solid tumors where limited efficacy is currently seen. (oncotarget.com)
Apart from this, 6 other bispecific antibodies have gained market authorization for various indications including Hemlibra for hemophilia, Blincyto for acute lymphoblastic leukemia, Rybrevant for non-small cell lung cancer, Vabysmo for Neovascular (Wet) Age‑related Macular Degeneration (AMD) and Diabetic Macular Edema (DME), Cadonilimab for cervical cancer, and Lunsmio for follicular lymphoma. (researchandmarkets.com)
The immune response triggered by antibodies against antigens present in the vascular wall participates in the formation and progression of AAA through mechanisms not completely understood. (bvsalud.org)
cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)
Immunophenotyping relies on detecting specific antigenic determinants on the surface of WBCs by antigen-specific monoclonal antibodies that have been labeled with a fluorescent dye or fluorochrome, such as phycoerythrin (PE) or fluorescein isothiocyanate (FITC). (cdc.gov)
Monoclonal antibodies attach to specific proteins or antigens. (who.int)

The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
The antibody is produced by a white blood cell called a B lymphocyte , based on the foreign antigen. (sciforums.com)
T cell activation, for example, needs three steps: (1) The lymphocyte T cell receptor (TCR) interacts with the antigen-loaded class II molecule in the first phase. (pharmacygyan.com)
T cells are a type of white blood cell called a lymphocyte, which is formed in the blood but develops further in the thymus and plays a role in the immune system. (differencebetween.net)
The T cells are a type of lymphocyte that is initially created in the bone marrow from hematopoietic stem cells. (differencebetween.net)
T cells are a type of white blood cell called a T lymphocyte. (differencebetween.net)
A T cell is a type of lymphocyte that has T cell-type receptors on the plasma membrane of the cell. (differencebetween.net)
For example it has been proposed that MZ B cells might impede defensive Lymphocyte reactions during early Leishmania donovani disease. (alliedacademies.org)
In this report, MZ B cell lack was related with further developed Lymphocyte reactions and diminished parasite trouble in vivo. (alliedacademies.org)
B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)

We found that the expanded cells possessed significantly improved immune effector functions, including proliferation, differentiation, and cancer cell killing, both in vitro and in the humanized mouse model. (nature.com)
This results in the formation of germinal centers (GCs), where antigen-activated B cells are trapped to undergo somatic mutation, positive and negative selection, isotype switching, and differentiation into high-affinity plasma cells and memory B cells. (wikipedia.org)
Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells. (ox.ac.uk)
Multiple cytokines can synergize to stimulate the in vitro proliferation and exclusive myeloid differentiation of multipotent bone marrow progenitor cells. (ox.ac.uk)
SCF in combination with interleukin-7 (IL-7) can also stimulate the combined myeloid and B-cell differentiation of uncommitted hematopoietic progenitor cells as well as the growth of early B-cell progenitor cells, although the involvement of c-kit in early B lymphopoiesis remains controversial. (ox.ac.uk)
Nagata K, Nakamura T, Kitamura F, Kuramochi S, Taki S, Campbell KS, Karasuyama H: The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation. (exbio.cz)
In the skin, nAChRs regulate the activity of genes involved in the growth and division (proliferation), maturation (differentiation), and survival of cells. (medlineplus.gov)
Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium. (medlineplus.gov)
Favre B, Plantard L, Aeschbach L, Brakch N, Christen-Zaech S, de Viragh PA, Sergeant A, Huber M, Hohl D. SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda. (medlineplus.gov)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
Early stages of B-cell differentiation can be identified by the status of the immunoglobulin genes and by the cell surface markers CD34, CD19, and surface immunoglobulin (sIg). (medscape.com)

The cytotoxic T cells kill pathogens that are marked with particular proteins and are very specific in their action. (differencebetween.net)
A T cell varies in structure depending on what specific type it is, but all of these cells have special proteins on the cell membrane called T cell receptors. (differencebetween.net)
Like many receptors on the cell surface, the antigen receptors on the surface of lymphocytes are taken up into the cell by endocytosis together with the antigens they bind.1,2 This is surprising because the antigens recognized by the TCR, the peptide-MHC complexes, are integral membrane proteins, which do not Rabbit Polyclonal to HDAC7A normally pass from one cell membrane to another. (findadig.com)
They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). (exbio.cz)
These proteins play important roles in terms of determining host range and tropism and in delivering the RNA genome into the cytoplasm of the host's cells. (medscape.com)
Host susceptibility depends on the presence of specific cellular membrane receptor proteins that bind different enteroviral types along taxonomic lines. (medscape.com)
Like other Ly6/uPAR-related proteins, SLURP-1 folds into a particular shape and is thought to attach (bind) to other proteins called receptors to carry out signaling within cells. (medlineplus.gov)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)

Severe combined immunodeficiency (SCID) mice models demonstrate that these precursors may be transmitted to recipients with bone marrow allotransplants, in which case both donors' and recipients' FDCs networks may later be found in recipients' lymphoid compartments. (wikipedia.org)
T cells are produced from stem cells in the bone marrow which later differentiate in the thymus. (differencebetween.net)
In the present study, the flt3-ligand (FL), which, in combination with other cytokines, has overlapping activities with SCF on myeloid cell production from uncommitted progenitors, was investigated for its ability to induce selective stroma-independent B-cell commitment from uncommitted Lin-Sca-1+ bone marrow progenitor cells. (ox.ac.uk)
50 cells), whereas the combined stimulation with FL and IL-7 resulted in clonal growth of 10% of Lin-Sca-1+ bone marrow cells. (ox.ac.uk)
Recent clinical data indicate that patients with complex karyotypes, adverse genes, and high pre-infusion minimal residual disease (MRD) by flow cytometry in the bone marrow, were at high risk of relapse after CAR T-cell therapy. (biomedcentral.com)
High pre-lymphodepletion lactate dehydrogenase, low pre-lymphodepletion platelet count, absence of fludarabine in lymphodepletion, persistent leukemic sequence by high throughput sequencing in bone marrow after CAR T-cell infusion, and early loss of CAR T cells have also been linked to relapse after CAR T-cell therapy. (biomedcentral.com)
It affects the bone marrow and white blood cells - which explains why the CT scan discovered hot spots in Eliza's bone marrow. (choc.org)
Recipients of grafts containing immune cells (particularly bone marrow, intestine, and liver) are at risk of graft-vs-host disease, in which the donor immune cells attack recipient tissue. (msdmanuals.com)
In the fetal bone marrow, the first committed cell in B-cell development is the early pro-B cell, identified by its ability to proliferate in the presence of interleukin-7 (IL-7). (medscape.com)
The completion of rearrangement of the light and heavy chains and the presence of surface IgM results in the immature B cell, which then leaves the bone marrow. (medscape.com)

Recently, Janssen Pharmaceutical has developed Teclistamab which is an investigational, fully humanized, T-cell redirecting, IgG4 bispecific antibody targeting both BCMA (B-cell maturation antigen) and CD3, the T-cell receptor. (researchandmarkets.com)

However, unlike DES, in utero/lactational exposure to GEN did not increase expression of the proliferation marker, proliferating cell nuclear antigen (PCNA), in the luminal epithelial cells of the 2-month-old rat uteri. (mcmaster.ca)
MCL can be both indolent or aggressive, in either case it responds poorly to chemotherapy and consequently the aggressive form has a dismal prognosis assessed by incorporating Ki-67 proliferation index and Mantle Cell International Prognostic Index scores. (bmj.com)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)

TNF-a binds on the TNFRI receptor, while LT interacts with LTβ-receptor expressed on FDC precursors. (wikipedia.org)
3) The T cell's CD28 binds with a B7 molecule on the APC in the last stage of the activation cycle (antigen-presenting cell). (pharmacygyan.com)
An antibody is a protein called an immunoglobulin, which binds to antigens or helps stop functions of pathogens through disrupting certain processes. (differencebetween.net)
The A1 antibody binds to the human CD39 cell surface antigen and has been shown to block MHC independent target cell recognition by hapten-specific CTL. (biolegend.com)
When [BT-ON014 trade name] binds to HER2 it stops the growth of such cells and causes them to die. (who.int)

In approved products, a patient's own T lymphocytes are collected by apheresis and transduced with a gene that encodes for a CAR to direct the T cells against cancer cells. (medscape.com)
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
T cells are one of the types of lymphocytes that develop in the thymus. (differencebetween.net)
The T cells are a class of lymphocytes that function in the cell-level immune response of the body. (differencebetween.net)
Introduction T lymphocytes and B lymphocytes are the 2 main cell types responsible for the adaptive immune response in vertebrates. (findadig.com)
Antigen recognition results in activation of the lymphocytes, the acquisition of their effector functions, and their cooperation with other cell types in the course of the adaptive immune response. (findadig.com)
We have a superior comprehension of the basic cooperations between CD4+ Lymphocytes and B cells and the key transcriptional controllers that are significant for germinal focus (GC) reactions, and the heterogeneous populaces of memory cells that rise out of the GC (both enduring plasma cells (LLPCs) and memory B cells (MBCs) [ 1 ]. (alliedacademies.org)
The pathogenesis of acquired immunodeficiency syndrome (AIDS) is largely attributable to the decrease in T-lymphocytes bearing the CD4 receptor (CD4+) (1-5). (cdc.gov)
and the percentage of lymphocytes that are CD4+ T-cells. (cdc.gov)

Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. (biomedcentral.com)
Later, upon B-cell activation, the immunoglobulin loci undergo two additional and distinct genetic alterations (Figure 1 ). (biomedcentral.com)
An antibody is a protein known as an immunoglobulin, which attaches to antigens or inhibits pathogen movement or protein synthesis in some way. (differencebetween.net)
Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. (exbio.cz)
Teh YM, Neuberger MS: The immunoglobulin (Ig)alpha and Igbeta cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice. (exbio.cz)
The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)
For other B-cell defects, such as specific Ig deficiencies (eg, immunoglobulin A [IgA] or immunoglobulin G [IgG] subclass deficiencies), refer to the article B-Cell Disorders. (medscape.com)

Earlier HIV infec- receptor gene polymorphism in HIV infection, tion diagnosis, inhibition of ongoing HIV replica- only genes of the HLA system were thought to tion with antiretroviral therapy (in industrialized protect against HIV infection. (cdc.gov)
The role of genes ceptibility to HIV infection and the course of HIV of the human leukocyte antigen (HLA) system in disease. (cdc.gov)
The discovery of the gene sequences and predicted protein structures, role of CCR5 alleles has prompted studies of but their ligands have not been identified the possible role of many other host genes in (orphan receptors). (cdc.gov)
After cloning the antibody genes into an expression vector, this is then transfected into an appropriate host cell line for antibody expression. (cellsignal.com)
A handful of genes exempt themselves from this standard of immutability, however, most notably the loci that encode antigen receptors in B cells and T cells. (biomedcentral.com)
To create a repertoire of antigen-specific TCRs, alternative forms of genes present in somatic cells are rearranged in a process, called somatic cell recombination, by using RAG-1 and RAG-2 recombinase activating enzymes showing in above figure. (pharmacygyan.com)
Researchers speculate that without SLURP-1, the activity of genes controlled by nAChR signaling is altered, leading to overgrowth of skin cells or survival of cells that normally would have died. (medlineplus.gov)
Genes required for B cell development. (medscape.com)
These cells develop into late pro-B cells in which rearrangement of the heavy chain genes occurs. (medscape.com)
Progression from this late pro-B-cell to the pre-B-cell stage involves the rearrangement and joining of the various segments of the heavy chain genes. (medscape.com)

The educational activity features expert faculty evaluating the current treatment landscape of CAR T-cell therapy for relapsed/refractory LBCL, highlighting evidence set to transform clinical practice particularly in the second-line setting. (reachmd.com)
This activity will serve as the foundation for a robust panel discussion activity entitled Paradigm Shifts in CAR T-Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma: A Video Panel Discussion, where an expert faculty panel will provide their insights on how this new emerging evidence can and should be considered for real-world clinical practice. (reachmd.com)
Consolidative allogeneic hematopoietic stem cell transplantation after chimeric antigen receptor T-cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia: who? (biomedcentral.com)

In this respect, the introduction of checkpoint inhibitors to unleash the activity of tumor-reactive T cells has been a milestone in cancer immunotherapy. (nature.com)

Coupled with selection for B cells expressing high-affinity antigen receptors, hypermutation enhances the efficiency and specificity of the immune response. (biomedcentral.com)
Fc epsilon RI alpha is a transmembrane protein that associates with beta and gamma subunits to form the high affinity IgE receptor on basophils and mast cells. (rndsystems.com)

Activation does not need antigen processing by APCs or presentation by MHC molecules. (pharmacygyan.com)
Whereas B cells recognize native, unprocessed antigens IRAK inhibitor 3 using their B-cell receptor (BCR), T cells recognize antigenic peptides bound to major histocompatibility complex (MHC) molecules on the surface of antigen-presenting cells (APCs) using their T-cell receptor (TCR). (findadig.com)
Previous studies have suggested that by using the LPS core, Gram-negative bacteria can interact with several C-type lectin receptors that are expressed on antigen-presenting cells (APCs).Hypothesis/Gap Statement. (cdc.gov)
Invasion assays and inhibition assays were used to examine the ability of S. sonnei WT and its rough strain to invade APCs and investigate whether CD209 and CD207 are receptors for phagocytosis of rough S. sonnei. (cdc.gov)
This work demonstrated that S. sonnei rough strains - by losing the virulence plasmid - invaded APCs through interactions with CD209 and CD207 receptors. (cdc.gov)

Activated B-cells with low affinity to antigen captured on FDCs surface as well as autoreactive B-cells undergo apoptosis, whereas B cells bound to FDCs through the antigen complex, survive due to apoptosis blockage caused by interaction with FDCs. (wikipedia.org)
1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)

Thus, the local immunological milieu in tissue compartments forms the nature and magnitude of the host responses, i.e., frequencies of regulatory T cells (Tregs) vs. T-helper 17 (Th17) cells, amount of pro-inflammatory cytokines vs. anti-inflammatory cytokines, extent of neutrophilia and antigen-presenting-cell (APC) activation, among others. (frontiersin.org)
Just weeks later, the firm saw regulatory success with Yescarta (axicabtagene ciloleucel), which became the second chimeric antigen receptor (CAR) T-cell therapy to be commercialized in the US. (bioprocessintl.com)
of potent competitive regulatory pathways between NK and Compact disc8 T cells in response to systemic activation. (healthcarecoremeasures.com)
CD39 and CD73 have been found on regulatory T cells, specifically the effector/memory like T cells. (biolegend.com)

it recognizes a specific protein on the surface of malignant cells (eg, CD19 on B-cells). (medscape.com)
This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. (exbio.cz)
An antibody is a protein that has various chains, some of which are modified for attachment to antigens. (differencebetween.net)
Upon antigen recognition, the B cell internalizes the antigen, processes IRAK inhibitor 3 it into protein fragments, and presents these peptides bound to MHC class II molecules on its own surface. (findadig.com)
CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). (biolegend.com)
Taken together, these results suggest that, unlike protein antigens, TNF-alpha has multiple and central roles in TDI-induced asthma, influencing both nonspecific inflammatory processes and specific immune events. (cdc.gov)
This protein is found in skin cells and other cells that line the surfaces and cavities of the body. (medlineplus.gov)
10%. In the remaining 10% of children with lecular weight protein found on the surface nephrotic syndrome, it is largely mediated of all nucleated cells which synthesize it. (who.int)

Possible functions of FDC include: organizing lymphoid tissue's cells and microarchitecture, capturing antigen to support B cell, promoting debris removal from germinal centers, and protecting against autoimmunity. (wikipedia.org)
Follicular DCs are a non-migratory population found in primary and secondary follicles of the B cell areas of lymph nodes, spleen, and mucosa-associated lymphoid tissue (MALT). (wikipedia.org)
Interaction between FDCs precursors and lymphoid cells mediated by TNF-a and lymphotoxin (LT) is crucial for normal FDC development and maintenance. (wikipedia.org)
In normal lymphoid tissue, recirculating resting B cells migrate through the FDC networks, whereas antigen-activated B cells are intercepted and undergo clonal expansion within the FDC networks, generating germinal centers (GC). (wikipedia.org)
FDCs are among main producers of the chemokine CXCL13 which attracts and organises lymphoid cells. (wikipedia.org)
Factor Mfge produced in lymphoid tissues mainly by FDCs is known to enhance engulfment of apoptotic cells. (wikipedia.org)
They capture immune complexes in CR1/2-dependent way either directly from the lymph or from macrophages, and move to the lymphoid tissue, where they transfer complement opsonized antigen to the FDCs. (wikipedia.org)
Chimeric antigen receptor-modified T (CAR T) cells exhibit very effective function in elimination of relapsed/refractory B-cell lymphoid malignancies, we investigated their use in a patient with relapsed MCL. (bmj.com)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
The mature B cells circulate between secondary lymphoid organs and migrate into lymphoid follicles of the spleen and lymph nodes in response to further stimuli and various chemokines. (medscape.com)

We describe the role of allelic polymorphism in the gene coding for the CCR5 chemokine receptor with regard to susceptibility to and disease course of HIV infection. (cdc.gov)
Pre- hematopoietic and other cells, but the Duffy sence of one copy of the deleted CCR5 gene also antigen of erythrocytes (DARC) is the only influences the course of disease as the onset of member expressed on cells of erythroid lineage. (cdc.gov)
Early in B- and T-cell development, site-specific cleavage and rejoining of V, D and J gene segments occurs to encode functional antigen receptors. (biomedcentral.com)
1 Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital. (aacrjournals.org)
Patients with relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL) often have clinicopathological characteristics associated with poor prognosis, such as high tumor burden and high-risk gene mutations. (biomedcentral.com)
S. sonnei contains a 210kb virulence plasmid that encodes an O-antigen gene cluster of LPSs. (cdc.gov)
An estimated 90% of patients with early-onset agammaglobulinemia and absence of B cells have abnormalities in the Btk gene (ie, Bruton agammaglobulinemia or XLA). (medscape.com)

and (5) some of the daughter cells will act as progenitor cells. (pharmacygyan.com)
Interestingly, although all FL + IL-7-responsive Lin-Sca-1+ progenitor cells and the resulting pro-B cells expressed c-kit, FL + IL-7 was much more potent (62-fold) than SCF + IL-7 in stimulating production of cells of the B-cell lineage. (ox.ac.uk)
These results show that FL much more potently and selectively than SCF synergizes with IL-7 to enhance B-cell commitment and development from uncommitted progenitor cells. (ox.ac.uk)

Nevertheless, ex vivo activation with cytokines can restore cytolytic activity of NK cells against GB, indicating that NK cells have potential for adoptive immunotherapy of GB if potent cytotoxicity can be maintained in vivo . (frontiersin.org)

The SR84 monoclonal antibody specifically recognizes CD49a (CD49 antigen-like family member A). CD49a is a ~200 kDa type I transmembrane molecule that is encoded by ITGA1 ( Integrin subunit alpha 1). (bdbiosciences.com)
The Armenian hamster monoclonal antibody HM79 recognizes an extracellular epitope of mouse CD79b (CD79 beta, Ig beta), a component of B cell receptor (BCR) complex. (exbio.cz)

Mammalian cell lines are most commonly used for recombinant antibody production, although cell lines of bacterial, yeast, or insect origin are also suitable. (cellsignal.com)
Janssen will present the results from the Phase 1 and 2 MajesTEC-1 ( Abstract #896 ) studies evaluating teclistamab (BCMAxCD3), an investigational, off-the-shelf, T-cell redirecting bispecific antibody in heavily pre-treated patients with multiple myeloma. (jnj.com)
Updated results from the Phase 1 MonumenTAL-1 ( Abstract #158 ) study, evaluating talquetamab (GPRC5DxCD3) - an investigational, off-the-shelf, T-cell redirecting bispecific antibody and the first directed at this novel target for heavily pre-treated patients with multiple myeloma - will be featured in an oral presentation. (jnj.com)
Histograms show the level of SSTR2-specific antibody binding to wild-type Jurkat T cells (0%, top) and Jurkat T cells transduced with increasing virus titers. (jci.org)
B ) Level of SSTR2-specific antibody binding to SSTR2-transduced Jurkat T cells with and without preincubation with 1 μM octreotide (37°C, 30 minutes). (jci.org)
So how this long rerm antibody can exist without reinfection or antigen presentation? (sciforums.com)
Each B cell produces a single species of antibody, each with a unique antigen-binding site. (sciforums.com)
When a naïve or memory B cell is activated by antigen (with the aid of a helper T cell), it proliferates and differentiates into an antibody-secreting effector cell. (sciforums.com)
Allison's research into the biology of T cells, white blood cells that serve as the immune system's customized guided weapons, led him to develop an antibody that blocks an off switch on those cells, unleashing an immune response against cancer. (mdanderson.org)
For instance, Xencor and Janssen Biotech have entered an exclusive collaboration and global license agreement for the development and commercialization of plamotamab and XmAb CD28 bispecific antibody combinations to treat patients with B-cell malignancies. (researchandmarkets.com)
Defective antibody production and low circulating numbers of B cells were described in some female infants and in males in whom no Btk abnormalities were detected. (medscape.com)

Vγ9Vδ2 T cells recognize pyrophosphates secreted by many microbes or overproduced by malignant cells in the context of butyrophilin 3A1 molecules. (nature.com)
Unlike other DCs and macrophages, FDCs lack MHC class II antigen molecules and express few pattern-recognition receptors, so they have little ability to capture non-opsonized antigens. (wikipedia.org)
Adhesion between FDCs and B cells is mediated by ICAM-1 (CD54)-LFA-1 (CD11a) and VCAM-VLA-4 molecules. (wikipedia.org)
CD49a is also known as very late antigen 1α subunit (VLA-1) of the integrin family of cell adhesion molecules. (bdbiosciences.com)
Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. (mdpi.com)
CDR2s interact with the class II molecules but are not involved in antigen recognition. (pharmacygyan.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
As an evasion mechanism, many tumors are able to stimulate the expression of immune checkpoint molecules, resulting in an exhausted phenotype of T cells that cannot restrain tumor progression [ 1 ]. (oncotarget.com)

One major discovery was that members of the chemokine receptor family serve as cofactors for HIV entry into cells. (cdc.gov)
Several human chemokine receptors have been sons than for those homozygous for the wild classified as such on the basis of similarity of type CCR5 (12,17-19,23). (cdc.gov)
What Are Chemokine Receptors? (cdc.gov)

J Cell Biol. (exbio.cz)

γδ T cells, specifically the Vγ9Vδ2 subset, which is the dominate subset among γδ T cells in human peripheral blood, recognize target cells in a human leukocyte antigen (HLA)-independent manner. (nature.com)
Immunological memory is the ability of the immune system to quickly and specifically recognize an antigen that the body has previously encountered and initiate a corresponding immune response . (sciforums.com)
Above link sugfests that immunological memory quucklyand specifically recognize an antigen that the body has previously encountered and initiate a corresponding immune response . (sciforums.com)
The CARs allow the T-cells to recognize, target, and destroy cancer cells. (shebaonline.org)

Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. (nature.com)
While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)
Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
Timely CAR T cell infusions resulted in survival of tumor-bearing mice, while later infusions led to uniform death. (jci.org)
Real-time PET imaging revealed biphasic T cell expansion and contraction at tumor sites among survivors, with peak tumor burden preceding peak T cell burden by several days. (jci.org)
In contrast, nonsurvivors displayed unrelenting increases in tumor and T cell burden, indicating that tumor growth was outpacing T cell killing. (jci.org)
Jim Allison found a way to remove the brakes that stop T cells from fighting tumor cells - a discovery that opens brand new and very effective ways to treat cancer," said Joseph Goldstein, M.D., chair of the Lasker Medical Research Awards Jury, Nobel Laureate and chair of Molecular Genetics at The University of Texas Southwestern Medical Center in Dallas. (mdanderson.org)
Tumor growth diminished 5 times and tumor weight reduced 50-80% when compared with the anti-CAIX CAR T cells alone in a humanized mice model of ccRCC. (oncotarget.com)
The anti-PD-L1 IgG1 isotype, which is capable of mediating ADCC, was also able to recruit human NK cells to the tumor site in vivo . (oncotarget.com)
Preclinical studies have shown that Teclistamab redirects CD3-positive T-cells to BCMA-expressing myeloma cells to induce killing of tumor cells. (researchandmarkets.com)
Early loss or exhaustion of CAR T cells, selection of CD19-negative clones, downregulation of CD19 expression, lineage switch of leukemia, and tumor microenvironment are important factors contributing to relapse after CAR T-cell therapy [ 9 , 10 ]. (biomedcentral.com)

Mahnke K, Guo M, Lee S, Sepulveda H, Swain SL, Nussenzweig M, Steinman RM: The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. (exbio.cz)

This enables cells to communicate and respond to external environments, maintain cellular homeostasis, and transduce signals. (mdpi.com)
Cellular activation by IgE/Fc epsilon RI crosslinking causes degranulation, releasing histamine, leukotrienes, prostaglandins, and other mediators of immediate‑type and late‑phase allergic reactions. (rndsystems.com)
There are several types of T cells that are made, which work together with each other and with the B cells to bring about a cellular immune response. (differencebetween.net)
One of the new emerging mechanisms associated with the progression of clear cell renal cell carcinoma (ccRCC) and other tumors is the immune checkpoint pathway, which consists of cellular interactions that prevent excessive activation of T cells under normal conditions. (oncotarget.com)
The multi‑dimensional nature of their roles in cellular homeostasis, cell‑to‑cell and tissue‑to‑tissue communication at the level of the organism, as well as their actions on the holobiome (intra‑/interspecies interaction), have garnered the interest of a large number of researchers. (spandidos-publications.com)
They are an integral part of the later phase of the cellular stress response, i.e. the stress-induced senescence-like phenotype, as well as the senescence-associated secretory phenotype. (spandidos-publications.com)
For decades, allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been regarded as the only well-established curative cellular therapy for patients with B-ALL. (biomedcentral.com)
Advances in cellular immunotherapy that spur genetically modified T cells to attack cancer cells have revolutionized the treatment of certain blood cancers. (wustl.edu)

The stimulation of CXCR5 on B cells upregulates LT production, which leads to FDCs activation and stimulates further CXCL13 secretion, thus generating a positive feed-forward loop. (wikipedia.org)
Expression of CD39 is induced on T cells and increased on B cells as a late activation antigen. (biolegend.com)
Verbenalin inhibits the activation of inflammatory signaling pathways induced by lipopolysaccharide (LPS) and IgG immune complex (IgG IC) via GPR18 receptor activation. (bvsalud.org)

Follicular DCs have high expression of complement receptors CR1 and CR2 (CD 35 and CD 21 respectively) and Fc-receptor FcγRIIb (CD32). (wikipedia.org)
Expression of human SSTR2 by lentivirus vector in T cells. (jci.org)
Diethylstilbesterol (DES) also stimulated uterine PR expression only in the glandular but not luminal epithelial cells. (mcmaster.ca)
Fc epsilon RI expression on human DC and Langerhans cells is upregulated during allergic reactions (atopy) and correlates with serum IgE concentration. (rndsystems.com)
The expression of PD-L1 and Ki67 in the tumors decreased and an increase in granzyme B levels was found in CAR T cells. (oncotarget.com)
SDS-PAGE silver staining was used to examine the O-antigen expression of S. sonnei WT and its rough strain. (cdc.gov)
Expression of the O-antigen reduces the ability of the S. sonnei rough strain to be disseminated to mesenteric lymph nodes and spleens.Conclusion. (cdc.gov)
1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
Increasing expression of IgD in the transitional cells finally results in the mature B cell with IgM and IgD both expressed on their cell surface. (medscape.com)

To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy, the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized, and clinical safety and efficacy also need to be proven. (nature.com)
The intracellular domains ensure intracellular signaling necessary to activate the effector functions of the CAR T cell. (medscape.com)
These cycles bring about extended populaces of both early effector cells that can discharge abundant measures of immune response as well as seemingly perpetual populaces of B cells that can safeguard against auxiliary contaminations. (alliedacademies.org)

This work analyses the function of specific IgG receptors (FcÎ³R), especially those expressed by monocytes/macrophages, in the development of experimental AAA. (bvsalud.org)
Although CD4 T cells are the main targets of HIV infection, macrophages also become infected and resist the cytopathic effects of infection, contributing potentially to HIV reservoir persistence. (nih.gov)

While UV1 implements specific amino acid chains representative of the human telomerase enzyme's (hTERT) reverse transcriptase subunit to help the native immune response target cancer cells, cancer vaccines that utilize mRNA technology have therapeutic potential in low-treatment option cancers, including many of those linked to occupational hazards. (biospace.com)
CD49a associates with the integrin β1 subunit (CD29) to form the α1/β1 heterodimer (CD49a/CD29), and serves as receptor for collagen and laminin-1. (bdbiosciences.com)
Echovirus serotypes 1 and 8 bind a subunit of the very late antigen (VLA) integrin molecule. (medscape.com)
B29), and the -subunit of the E-mail: [email protected] interleukin (IL)-7 receptor [5, 6]. (lu.se)

But by then, there was a cadre of researchers working in the field, and we began to make progress in understanding that the antigen receptor was a kind of molecular switch, but it became clear it was much more complicated than that. (ascopost.com)
Mantle cell lymphoma (MCL) is a type of non-Hodgkin B cell lymphoma with a distinctive molecular marker cyclin D1 that is constitutively overexpressed in almost all cases. (bmj.com)

SSTR2-based PET was applied to ACT of chimeric antigen receptor (CAR) T cells targeting intercellular adhesion molecule-1, which is overexpressed in anaplastic thyroid tumors. (jci.org)

interleukin (IL)-6 levels are elevated in the blood, but not nearly as high as we see in other cytokine storms, particularly in something called cytokine release syndrome, which we can see from chimeric antigen receptor (CAR) T cell therapy, for example, for refractory leukemia. (hcplive.com)

Although anti-CD19 chimeric antigen receptor (CAR) T-cell therapy shows good efficacy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL), it fails to improve long-term leukemia-free survival (LFS). (biomedcentral.com)

The first report of CAR T-cell therapy was in 2010, in a patient with advanced follicular lymphoma. (medscape.com)
Kochenderfer et al described dramatic regression of the lymphoma after infusion of CAR T cells engineered to target CD19. (medscape.com)
This chimeric antigen receptor (CAR) T-cell therapy is indicated for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL), primary mediastinal large B-cell lymphoma (PMBCL), and follicular lymphoma grade 3B (FL3B). (medscape.com)
I was just 31 and about to give birth to my fourth child, Yitzchok, when I received a diagnosis of primary mediastinal large B-cell lymphoma . (cancer.net)
A biopsy confirmed the mass was primary mediastinal large B-cell lymphoma. (cancer.net)
Despite the aggressive treatment, which initially put the lymphoma into remission, the cancer recurred several months later. (cancer.net)
Since the first chimeric antigen receptor (CAR) T-cell therapy was approved by the US Food and Drug Administration (FDA) for the treatment of large B-cell lymphoma (LBCL) in the third or later line of therapy, there has been significant development in the field. (reachmd.com)
The NCCN guideline for PTLD, which is integrated into the larger B-cell lymphoma guideline, provides the following algorithm to diagnose the disorder with steps categorized as either "essential" or "useful under certain circumstances. (medscape.com)
Background The aggressive form of Mantle cell non-hodgkin B cell lymphoma (MCL) has a dismal prognosis. (bmj.com)
Conclusions This case suggests that haplo-CAR T cell therapy can be effective in controlling lymphoma that failed to respond to autologous CAR T cell therapy and overcome limitation of autologous CAR T cells, thus may be one possible regimen before the era of off-the-shelf "universal" CAR T cell therapy. (bmj.com)

It is expressed on activated T cells, monocytes, neuronal cells and smooth muscle cells. (bdbiosciences.com)
It is produced by Idiopathic nephrotic syndrome (INS) a variety of cells, including monocytes and accounts for 90% of nephrosis in child- mesangial cells in the kidney [ 9 ]. (who.int)

Specific types of T cells have particular functions, with helper cells activating other cells of the immune system while cytotoxic T cells directly kill foreign cells and viruses. (differencebetween.net)
CAR T-cell therapy is an innovative procedure that makes use of your own immune system to seek and destroy cancerous cells. (shebaonline.org)
With CAR T-cell therapy, we are able to harness the patient's own immune system to potentially cure their leukemia," says Dr. Huynh, Director of CHOC's Leukemia Program and CAR T-Cell Therapy Program. (choc.org)

Trastuzumab is designed to attach to an antigen called human epidermal growth factor receptor 2 (HER2). (who.int)

Airway inflammation, goblet cell metaplasia, epithelial cell damage, and nonspecific airway reactivity to methacholine challenge, measured 24 h following the last challenge, were reduced to baseline levels in TNF-alpha null mice and athymic mice. (cdc.gov)

The T cell receptor is a heterodimer with two chains, one variable (V) and the other constant (C). The structure of an α/β TCR is shown in the Figure below. (pharmacygyan.com)

In mice lacking B cells, or with blocked TNF-a and lymphotoxin (LT) production, cells with FDC phenotype are missing. (wikipedia.org)
A cyclophosphamide (CP)-induced tolerance system in mice that primarily consists of donor cell injection followed by CP-treatment was found useful for inducing a long-lasting allo- or xeno-tolerance to various solid organs. (nih.gov)
Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)
In a later report, stroke-prompted loss of splenic MZ B cells in mice related with critical decrease in IgM levels and an unconstrained expansion in bacterial disease in the lungs of these mice, proposing a likely job for MZ B cells in restricting contaminations all through the body following a stroke episode [ 4 ]. (alliedacademies.org)
The viruses produced cytopathic effects in cell cultures but failed to cause detectable pathologic lesions in suckling mice. (medscape.com)

C ) DOTATOC uptake by SSTR2-transduced and wild-type Jurkat T cells versus input DOTATOC concentration is shown. (jci.org)
D ) DOTATOC uptake at 37°C and 4°C by SSTR2-transduced and wild-type Jurkat T cells is shown via Scatchard plot. (jci.org)
This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. (exbio.cz)
Fc epsilon RI on human antigen presenting cells mediates uptake and processing of allergens for presentation by class II MHC. (rndsystems.com)

ECIL-6 guidelines recommend quantitative PCR of whole blood, plasma, or serum to screen for EBV DNA in allogeneic hematopoietic stem cell transplant (HSCT) recipients and to monitor EBV DNA-emia. (medscape.com)
The ligand for c-kit (stem cell factor [SCF]) plays a key role in stimulating myeloid and erythroid cell production of primitive hematopoietic progenitors. (ox.ac.uk)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) after CAR T-cell therapy has emerged as a promising strategy to prolong LFS. (biomedcentral.com)
The patient received multiple molecularly targeted therapies, including targeting BTK and BCL2, and haplo-identical CAR T (haplo-CAR T) cells from her daughter without previous allo-hematopoietic stem cell transplantation. (bmj.com)
Hematopoietic Stem Cell Transplantation Hematopoietic stem cell (HSC) transplantation is a rapidly evolving technique that offers a potential cure for hematologic cancers ( leukemias, lymphomas, myeloma) and other hematologic disorders. (msdmanuals.com)
Living donors are often used for kidney and hematopoietic stem cell transplants, less frequently for segmental liver transplants, and rarely for pancreas and lung transplants. (msdmanuals.com)

They form a stable network due to intercellular connections between FDCs processes and intimate interaction with follicular B cells. (wikipedia.org)
Fuentes-Pananá EM, Bannish G, Shah N, Monroe JG: Basal Igalpha/Igbeta signals trigger the coordinated initiation of pre-B cell antigen receptor-dependent processes. (exbio.cz)

A Systematic Review of Mesenchymal Epithelial Transition Factor (MET) and Its Impact in the Development and Treatment of Non-Small-Cell Lung Cancer. (lu.se)

In all cells, high-fidelity pathways repair DNA to maintain the integrity of the genome. (biomedcentral.com)
Their multi‑functional cargo have been indicated to regulate a vast number of biological pathways in target cells. (spandidos-publications.com)

Phenotyping showed that greater than 99% of the cells produced were of the B-cell lineage, in that they expressed B220, but not cell surface markers specific for myeloid, erythroid, or T-cell lineages. (ox.ac.uk)
Exosomes, via their cargo or surface composition, are signals/mediators of systemic homeostasis and stress for specific cell-to-cell or tissue-to-tissue communication ( 5 ). (spandidos-publications.com)
It is well-documented that after losing the O-antigen and becoming rough strains, the Gram-negative bacteria may express an LPS core on its surface. (cdc.gov)
When the heavy chain is produced, it is transported to the cell surface by the Ig-α (CD79a) and Ig-β (CD82) heterodimers or by the surrogate light chain. (medscape.com)
HER2 is found in large amounts on the surface of some cancer cells where it stimulates their growth. (who.int)

Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy, which will inspire further clinical investigations and eventually benefit cancer patients. (nature.com)
We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)
A poster detailing the Phase I/II clinical trial for this asset was presented in a late-breaking session at the 36th Annual Meeting of the Society for Immunotherapy of Cancer (SITC). (biospace.com)
Dr. Huynh offered Eliza treatment with Chimeric Antigen Receptor (CAR) T-cell therapy - an innovative immunotherapy treatment for patients with relapsed ALL. (choc.org)

These receptors have both extracellular and intracellular components. (medscape.com)
Western blot analysis of extracts from various cell lines using PD-L1 (Extracellular Domain Specific) (E1J2J ™ ) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). (cellsignal.com)
Exosomes are small lipid bilayer-surrounded extracellular vesicles released from cells into the extracellular space or biological fluids ( 1 , 2 ). (spandidos-publications.com)

Since the late 1970s, 8.4 million people worldwide, including 1.7 million children, have died of AIDS, and an estimated 22 million people are infected with human immunodeficiency virus (HIV)(1). (cdc.gov)
At its late January meeting, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommended for approval lisocabtagene maraleucel (Breyanzi, Bristol-Myers Squibb). (medscape.com)
We utilized a human genetic reporter, somatostatin receptor 2 (SSTR2), and PET, to quantitatively and longitudinally visualize whole-body T cell distribution and antitumor dynamics using a clinically approved radiotracer. (jci.org)
Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10 6 cells in a suspension. (exbio.cz)
Gurer C, Strowig T, Brilot F, Pack M, Trumpfheller C, Arrey F, Park CG, Steinman RM, Münz C: Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses. (exbio.cz)
MAINZ, Germany I September 9, 2022 I BioNTech SE (Nasdaq: BNTX, "BioNTech" or "the Company") today presented positive follow-up data from its ongoing first-in-human Phase 1/2 trial evaluating the safety and efficacy of the Company's novel CAR-T cell therapy candidate, BNT211, in patients with relapsed or refractory advanced solid tumors. (pipelinereview.com)
It is a human NK cell associated antigen. (healthcarecoremeasures.com)
1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)

Haplo-CAR T cells could effectively proliferate in vivo and had a clinically significant antitumor activity without serious side effects. (bmj.com)

Gong S, Nussenzweig MC: Regulation of an early developmental checkpoint in the B cell pathway by Ig beta. (exbio.cz)

The genetically modified autologous T cells are expanded in vitro at a production facility and then reinfused into the patient. (medscape.com)

Due to their HLA-independent mode of action, allogeneic Vγ9Vδ2 T cells can be considered for clinical application. (nature.com)
Among these 132 patients, 8 liver cancer patients and 10 lung cancer patients who received ≥5 cell infusions showed greatly prolonged survival, which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy. (nature.com)

CD205, also known as DEC-205, is an endocytic receptor of macrophage mannose receptor family. (exbio.cz)
They are derived by a targeted mechanism from the cell endocytic compartment and are formed and stored within the intracellular multivesicular bodies (MVBs). (spandidos-publications.com)

Anatomy15

Organisms4

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes12

Information Science3

Chimeric antigen receptors4

Dendritic cells10

Antibodies25

Lymphocyte10

Differentiation11

Proteins8

Bone-marrow10

Maturation antigen1

Proliferation3

Binds5

Lymphocytes9

Immunoglobulin7

Genes10

Therapy for Relapsed3

Cancer immunotherapy1

High-affinity2

APCs5

Affinity2

Regulatory4

Protein8

Lymphoid10

Gene7

Progenitor Cells3

Cytokines1

Monoclonal antibody2

Antibody11

Molecules8

Chemokine3

Biol1

Recognize4

Tumor11

Endocytosis1

Cellular8

Activation3

Expression9

Effector3

Macrophages2

Subunit4

Molecular2

Molecule1

Interleukin1

Refractory B-cell1

Lymphoma10

Monocytes2

Immune system3

Epidermal1

Reactivity1

Heterodimer1

Mice5

Uptake4

Hematopoietic6

Processes2

Epithelial1

Pathways2

Surface5

Immunotherapy4

Extracellular3

Human8

Vivo1

Pathway1

Genetically1

Allogeneic2

Endocytic2