Cells producing. Medical search. Frequent questions

In type II diabetes - the most common form of the disease - the cells of the body become inefficient at responding to insulin and as a consequence, glucose in circulation can become dangerously high (hyperglycemia) while the pancreas cannot produce enough insulin to compensate. (newswise.com)
Researchers at UMass Medical School have discovered a new pathway that triggers regeneration of beta cells in the pancreas, a key development that may aid in the development of diabetes treatments. (umassmed.edu)
In an innovative study in mice, Laura Alonso, MD, the George F. and Sybil H. Fuller Foundation Term Chair in Diabetes and associate professor of medicine, and Rohit Sharma, PhD, a postdoctoral associate, discovered how the pancreas knows that more insulin-producing beta cells are needed. (umassmed.edu)
This may also explain the conundrum of why there do not appear to be stem cells in the pancreas," Alonso added. (umassmed.edu)
The death of insulin-producing beta cells in the pancreas is a core defect in diabetes. (medicaldaily.com)
Justin Annes, Tim Horton and colleagues developed a zinc-loving chemical compound (light blue) that helps deliver drugs that trigger insulin-producing cells in the pancreas (dark blue), but not others (gray), to replicate (red). (stanford.edu)
An insulin injection can manage diabetes symptoms, but actually curing the disease would mean healing cells in the pancreas that produce insulin, a hormone that regulates the amount of sugar in blood. (stanford.edu)
Now, a team of Stanford University endocrinologists and chemists has taken a step toward targeting the right cells more precisely, using a property that researchers have long known about but never exploited for treatment: Beta cells, the insulin-producing cells in the pancreas, have a particularly strong taste for zinc. (stanford.edu)
In other words, researchers might be able boost the number of beta cells in the pancreas, but in the process they'd get lots of other cell types to replicate as well. (stanford.edu)
As part of the new program, University of California San Diego School of Medicine researchers will receive $6.4 million in grant funding to study how external signals and genetic variations influence the behavior of one cell type in particular: insulin-producing beta cells in the pancreas. (ucsd.edu)
In diabetes, tiny clusters of insulin-producing 'beta cells' in the pancreas don't produce enough of the hormone to keep people healthy, and their blood glucose levels climb. (medicalxpress.com)
Insulin-producing cells in the pancreas are damaged by diabetes. (cellmedicine.com)
The cells could potentially be used to fill the void left in the pancreas due to the damage that is caused by diabetes. (cellmedicine.com)
Beta cells typically reside in the pancreas, where they act as the body's natural insulin-producing factories. (technologynetworks.com)
Press-News.org) VIDEO: Researchers discover a simple peptide that can induce new beta-cell formation in the pancreas. (press-news.org)
La Jolla, Calif., July 31, 2014 -- A new study by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) has found that a peptide called caerulein can convert existing cells in the pancreas into those cells destroyed in type 1 diabetes-insulin-producing beta cells. (press-news.org)
By introducing caerulein to the pancreas we were able to generate new beta cells-the cells that produce insulin-potentially freeing patients from daily doses of insulin to manage their blood-sugar levels. (press-news.org)
In those mice, but not in normal mice, they found that caerulein caused existing alpha cells in the pancreas to differentiate into insulin-producing beta cells. (press-news.org)
Alpha cells and beta cells are both endocrine cells meaning they synthesize and secret hormones-and they exist right next to one another in the pancreas in structures called islets. (press-news.org)

In the early embryo, embryonic stem cells give rise to all of the cell types in the organism, including adult stem cells, which continually replace cells in the adult tissues that die or differentiate into more mature cells like red blood cells. (sciencedaily.com)
The researchers went on to show that another protein, OCT4, which functions to maintain the stem cells in the early embryo and in cultured embryonic stem cells, is also present in the adult germ stem cell. (sciencedaily.com)
This important finding confirms earlier published studies suggesting that the adult germ stem cells are not far removed from embryonic stem cells. (sciencedaily.com)
Transplantation of pancreatic progenitors or insulin-secreting cells derived from human embryonic stem cells (hESCs) has been proposed as a therapy for diabetes. (nih.gov)
Three-dimensional bioprinting of embryonic stem cells directs highly uniform embryoid body formation, Biofabrication (2015). (phys.org)
According to their most recent paper published in the journal "Science Advances", the team has now successfully cultivated primordial germ cells (PGCs) - the precursors of eggs and sperm - from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). (izw-berlin.de)
They established culture systems for the southern white rhino, for which embryonic stem cells are available, and the northern white rhino, for which they used induced pluripotent stem cells derived from tissue samples. (izw-berlin.de)

Now researchers report that microbiota regulate the ability of lung dendritic cells to generate immune responses. (sciencedaily.com)
Microbiota--the trillions of bacteria that co-exist in the body--regulate the ability of lung dendritic cells to generate immune responses, according to a study led by researchers from the Icahn School of Medicine at Mount Sinai, published online in the Journal of Experimental Medicine . (sciencedaily.com)
To study the production of IgA within the lungs, the researchers used mouse models to isolate specialized cells called dendritic cells and cultured them with antibody-producing B cells. (sciencedaily.com)
To the researchers' surprise, they found that when they isolated lung dendritic cells from "germ free" or antibiotic-treated mice, the production of IgA was highly impaired. (sciencedaily.com)
Further, when the germ-free mice were fed with a component of bacterial cell wall called LPS, the lung dendritic cells started instructing B cells to produce IgA again. (sciencedaily.com)
Here we demonstrate that stimulation of mouse CD4(+) T cells by immature allogeneic dendritic cells combined with pharmacological inhibition of phosphodiesterase 3 (PDE) resulted in a functional enrichment of Foxp3(+) T cells. (lu.se)
These cells, described as macrophages or immature dendritic cells, deplete arginine and impair T cell proliferation and cytokine production. (aacrjournals.org)
Cell separation studies showed that the increased arginase activity was limited to a specific subset of CD11b+, CD14−, CD15+ cells with a polymorphonuclear granulocyte morphology and markers, instead of macrophages or dendritic cells described in mouse models. (aacrjournals.org)
B ) Muzzle skin was digested and analyzed via FACS for Siglec F + eosinophils (left panels), Ly- 6G + neutrophils (middle panels), Ly-6C + MHC-II lo monocytes and Ly-6C + MHC-II hi monocyte-derived dendritic cells (right panels). (elifesciences.org)

We investigated the effect of costimulation through CD28 and CD11a on the differentiation of human naive CD4 + T cells with restricted cytokine production profiles. (karger.com)
Organoids recovered from short-term infection with pks+ E. coli show characteristics of CRC cells, e.g., enhanced proliferation, Wnt-independence, and impaired differentiation. (uni-muenchen.de)
They were used for stimulation of mesenchymal stem cell differentiation into insulin-producing cells. (ualr.edu)
In vitro , POM1 stimulated differentiation of a greater number of dithizone-positive cells (also organized in clusters) than the second nanocompound (POM2). (ualr.edu)
Based on our in vitro studies, we have concluded that both the POMs tested had significant biological activity acting as active stimuli for differentiation of stem cells into insulin-producing cells. (ualr.edu)
However, differentiation and immune regulation of Th22 cells in tuberculous pleural effusion (TPE) remain unknown. (atsjournals.org)
The impacts of proinflammatory cytokines and antigen presentation by pleural mesothelial cells (PMCs) on Th22-cell differentiation were explored. (atsjournals.org)
IL-1β, IL-6, and/or tumor necrosis factor-α promoted Th22-cell differentiation from CD4 + T cells. (atsjournals.org)
Moreover, PMCs were able to stimulate CD4 + T-cell proliferation and Th22-cell differentiation by presenting tuberculosis-specific antigen. (atsjournals.org)
In particular, PMCs were able to function as antigen-presenting cells to stimulate CD4 + T-cell proliferation and Th22-cell differentiation. (atsjournals.org)
Pleural mesothelial cells stimulate CD4 + T-cell proliferation and Th22 cell differentiation in response to tuberculosis antigen. (atsjournals.org)
therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)

These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)
Peripheral blood mononuclear cells from 123 patients with metastatic renal cell carcinoma, prior to treatment, were found to have a significantly increased arginase activity. (aacrjournals.org)

Researchers have identified the first gene linked to the productivity of the stem cells that produce sperm in mammals. (sciencedaily.com)
What researchers are trying to do is unravel the mystery of the adult germ stem cells in male testicles, which are capable of producing an average of 1,500 sperm during every human heartbeat - or an average of 130 million sperm a day. (sciencedaily.com)
Researchers call stem cells 'pluripotent' cells, meaning that any given stem cell can become any of several types. (sciencedaily.com)
But researchers do not know how the germ stem cells "decide" whether to create other germ stem cells or commit to becoming sperm. (sciencedaily.com)
After a series of tests, the researchers concluded that because of the mutation, the cells were more likely to convert from germ stem cells into sperm, than to produce more germ stem cells to keep the process going. (sciencedaily.com)
Using modern methods and the published mouse genome sequence, UW researchers were able to identify the mutation at a gene called ZFP145, which produces the protein PLZF. (sciencedaily.com)
Using a fluorescent antibody against the PLZF protein, the researchers were able to show directly that PLZF is expressed in the adult germ stem cells. (sciencedaily.com)
Newswise - MEDFORD/SOMERVILLE, Mass. (November 1, 2019) -Tufts University researchers have transplanted engineered pancreatic beta cells into diabetic mice, then caused the cells to produce more than two to three times the typical level of insulin by exposing them to light. (newswise.com)
Researchers found that transplanting the engineered pancreatic beta cells under the skin of diabetic mice led to improved tolerance and regulation of glucose, reduced hyperglycemia, and higher levels of plasma insulin when subjected to illumination with blue light. (newswise.com)
Using cultured cells, the Washington University School of Medicine researchers found that the toxin MPP+ stopped the circulation of mitochondria in dopamine-producing cell axons, leading to the axonal withering and subsequently cell death. (genengnews.com)
Looking more closely at the mitochondria in treated cells, the researchers found that in some cases mitochondria seemed to be moving back toward the cell body, against the flow of other molecules and organelles, which suggested they were being trafficked back for repair. (genengnews.com)
Inspired by the efficiency with which plants convert sunlight into sugar, researchers have fabricated a solar cell that uses photosynthetic proteins to convert light into electricity. (sciencenews.org)
The key, Stanford researchers report, may be those cells' affinity for zinc. (stanford.edu)
In a study published online Dec. 6 in Cell Chemical Biology , Stanford researchers used that fact to selectively deliver a drug to beta cells. (stanford.edu)
Although some researchers deemed that impossible, Annes and his colleagues recently succeeded in creating specific molecules that make beta cells divide and produce more beta cells. (stanford.edu)
Then Annes had a thought: Researchers have known since the 1940s that beta cells collect about 1,000 times more zinc than surrounding tissue cells. (stanford.edu)
Researchers have mostly used that fact as a way to stain and visually identify beta cells in pancreatic tissue samples. (stanford.edu)
Researchers identified that an abundance of fungi in the gut, particularly strains of Candida albicans yeast, could trigger an increase in immune cells, which could worsen lung damage. (medicaldaily.com)
Friday, U.S. and British researchers reported that diabetes could be treated by using stem cells taken from the umbilical cords of newborns. (cellmedicine.com)
Researchers were able to take stem cells, expand them into a large number, and direct them to be similar to the insulin producing cells. (cellmedicine.com)
Researchers have created sterile animals capable of producing the fertile sperm of a different species through a technique called blastocyst complementation. (iflscience.com)
Stem cell research harnesses the versatility of cell types to produce tissue and organs but creating gametes such as sperm and egg have proven difficult to achieve (though researchers did recently make a mouse embryo from stem cells ). (iflscience.com)
The researchers, based at Tsinghua University, Beijing, China, and Drexel University, Philadelphia, USA, used extrusion-based 3-D printing to produce a grid-like 3-D structure to grow embryoid body that demonstrated cell viability and rapid self-renewal for 7 days while maintaining high pluripotentcy. (phys.org)
The researchers hope that this technique can be developed to produce embryoid body at a high-throughput, providing the basic building blocks for other researchers to perform experiments on tissue regeneration and/or for drug screening studies. (phys.org)
According to ARS, as a proof-of-concept, researchers showed that nanobodies targeting the SARS-CoV-2 virus could be made in plant cells and remain functional in blocking the binding of the SARS-CoV-2 spike protein to its receptor protein: the process responsible for initiating viral infection in human cells. (lawbc.com)
For decades, researchers have tried to duplicate the function of beta cells, the tiny insulin-producing entities that don't work properly in patients with diabetes. (technologynetworks.com)
Now, researchers at the at Chapel Hill and North Carolina State University have devised another option: a synthetic patch filled with natural beta cells that can secrete doses of insulin to control blood sugar levels on demand with no risk of inducing hypoglycemia. (technologynetworks.com)
Researchers at Lund University have instead chosen to investigate what protects the insulin-producing cells. (lu.se)
Previous studies by the same researchers have shown that C3 is also present inside cells and plays an important role there. (lu.se)
An objective among many diabetes researchers is to create treatments where stem cells are taken from the patient and converted into insulin-producing cells, which are then transplanted back into the patient. (lu.se)
Among researchers studying the immune system, there is no consensus on whether C3 plays a significant role inside our cells. (lu.se)

Diabetes is a disease in which the body can't produce enough insulin to maintain normal blood sugar levels. (stanford.edu)
In type 2 diabetes, beta cells don't produce enough insulin and other cells stop responding to it. (ucsd.edu)
But in people with diabetes, these cells are either damaged or unable to produce enough insulin to keep blood sugar levels under control. (technologynetworks.com)

Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)
continues Wei Sun. "However, these don't show the same cell uniformity and homogenous proliferation. (phys.org)
I think that we've produced a 3-D microenvironment which much more like that found in vivo for growing embryoid body, which explains the higher levels of cell proliferation. (phys.org)
Although arginase activity has been described in cancer patients, it is thought to originate from tumor cells metabolizing arginine to ornithine needed to sustain rapid cell proliferation. (aacrjournals.org)

Stage (S) 7 cells expressed key markers of mature pancreatic beta cells, including MAFA, and displayed glucose-stimulated insulin secretion similar to that of human islets during static incubations in vitro. (nih.gov)
In vitro, the mineralization ability of human rotator cuff cells from osteoarthritis donors was assessed by alizarin red or Von Kossa staining. (iasp-pain.org)
In vitro, tenocyte-like cells extracted from the rotator cuff were able to mineralize in osteogenic cultures, and expressed , , and , which are hypertrophic chondrocytes markers. (iasp-pain.org)
G ) Muzzle-infiltrating cells were isolated from LMC and Sox13 -/- mice and re-stimulated in vitro with PdBu/ionomycin to assess production of IL-5 and IL-13 by ILCs. (elifesciences.org)
D ) Muzzle-infiltrating cells were isolated from indicated mice, stimulated in vitro with PdBu/ionomycin, and analyzed for αβ T cell subset-specific production of IL-17A and IL-22 and for CD4 + T cell production of IL-4, and IL-13. (elifesciences.org)
The scientists of the BioRescue consortium have already produced northern white rhino embryos by in vitro fertilisation of oocytes with sperm. (izw-berlin.de)
Cytotoxicity of chromium and manganese to lung epithelial cells in vitro. (cdc.gov)

These cells - capable of generating all cell types in the body - could be used as the 'lego bricks' to build tissue constructs, larger structures of tissues, and potentially even micro-organs. (phys.org)
Calcifications were amorphous areas surrounded by a fibrocartilaginous metaplasia containing hypertrophic chondrocyte-like cells that expressed tissue non-specific alkaline phosphatase (TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), which are two key enzymes of the mineralization process. (iasp-pain.org)
With stem cell associated techniques (SCAT) the BioRescue scientists aim to overcome this bottleneck: By using stored and preserved tissue of rhino skin it should be possible in principle to create induced pluripotent stem cells (iPCSs), primordial germ cells and finally artificial gametes. (izw-berlin.de)
Naive CD4 + T cells can develop into various helper T (Th) subsets with different cytokine profiles and play a discriminative role in translating antigen-specific immune responses into tissue functions or immunopathology. (atsjournals.org)
Metastatic tumors also present in the skull base and may produce mass effect or invade adjacent tissue. (medscape.com)
During surgical procedures, smoke is produced when energy generating devices such as lasers or electrosurgical units also known as cautery are used to stop bleeding or incise tissue. (cdc.gov)
The energy generating devices raise the intracellular temperature to boiling (i.e., 100° C /212° F). At these high temperatures the tissue vaporizes producing surgical smoke. (cdc.gov)

Naive CD4 + T cells proliferated and produced IL-2 upon cross-linking of CD3, and costimulation through CD28 enhanced IL-2 production. (karger.com)

Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner. (iasp-pain.org)
We provide evidence that tenocytes have a propensity to differentiate into hypertrophic chondrocyte-like cells to produce TNAP-dependent calcium deposits. (iasp-pain.org)
To elucidate the mechanism by which Th22 cells differentiate and recruit into the pleural space. (atsjournals.org)
Although IL-22-producing helper T (Th22) cells have been reported to be involved in human tuberculosis, the mechanisms by which Th22 cells differentiate and are recruited into the pleural space are unknown. (atsjournals.org)

Buaas and Braun agreed that it sounded as if the mice were born with germ stem cells, the cells that produce sperm, but then lost their germ line early in puberty. (sciencedaily.com)
Nevertheless, S7 cells rapidly reversed diabetes in mice within 40 days, roughly four times faster than pancreatic progenitors. (nih.gov)
By that definition, the study created mouse-rat chimeras by introducing cells made up of rat genetic material inside the testes of mice. (iflscience.com)
In addition, one still needs to showcase the production of female reproductive cells (i.e., eggs) in female sterile mice, especially if we envision utilizing this technology for species conservation efforts. (iflscience.com)
Myeloid suppressor cells with high arginase activity are found in tumors and spleen of mice with colon and lung cancer. (aacrjournals.org)
Specific loss of Vγ2 + Tγδ17 cells, scratching behaviors and reciprocally enhanced effector function of ILCs in Sox13 -/- mice with dermatitis. (elifesciences.org)
H ) Increased skin γδ T cells, including Tγδ17 cells (TCRδ int ), in 4-6 week old Rora -/- mice. (elifesciences.org)
Aberrant αβ T cell activation in AD of Sox13 -/- mice. (elifesciences.org)
A ) Total number of the indicated T cell types recovered from skin of from 5-6mo mice were calculated using AccuCheck counting beads. (elifesciences.org)
B ) FACS analysis of CD4 neg CD8β neg skin T cells (gated on B220 - F4/80 - TCRβ + ) with control MR1/6-FP or MR1/5-OP-RU tetramer to identify MAIT cells in 5 mo mice. (elifesciences.org)
C ) Summary data of frequency of MAIT tetramer-reactive cells among total TCRβ + cells pooled from two independent experiments, performed as in Panel B analyzing a total of 5-6 mice/group. (elifesciences.org)
In sexually reproducing organisms such as humans, rhinos or mice, primordial germ cells (PGCs) are embryonic precursors of sperm and eggs that pass on genetic and epigenetic information from one generation to the next. (izw-berlin.de)
The scientists relied on knowledge from the mouse model: In 2016, Katsuhiko Hayashi and his team managed to create primordial germ cell-like cells and finally germ cells from mice that were fertilised in the lab and resulted in healthy offspring being born. (izw-berlin.de)
The study first examined how mice in which almost all beta cells were destroyed-similar to humans with type 1 diabetes-responded to injections of caerulein. (press-news.org)
To investigate this possibility, we generated mice with inducible knockout of Gsα in JG cells and monitored them for 6 months after induction at 6 weeks of age. (bvsalud.org)
We detected VEGF expression in JG cells of control mice , and cAMP agonists regulated VEGF expression in cultured renin -producing cells . (bvsalud.org)
Our data demonstrate that Gsα deficiency in JG cells of adult mice results in kidney injury , and suggest that JG cells are critically involved in the maintenance and protection of the renal microvascular endothelium . (bvsalud.org)

Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). (lu.se)

The findings, which could someday have implications for infertility, contraception, and stem cell transplantation therapy, will be published in the June issue of Nature Genetics. (sciencedaily.com)
But the stem cells have to walk a tightrope and carefully balance the decision to become a sperm with the decision to stay a stem cell, so that the sperm output is maintained for all of these years," said Dr. Robert Braun, associate professor of genome sciences in the University of Washington School of Medicine. (sciencedaily.com)
The workings of stem cells within the testicles are not well understood in mammals, though a few genes have been linked to stem cell self-renewal in the fruit fly, which has a simpler anatomical structure. (sciencedaily.com)
The team previously built human stem cell-based beta cell models in the lab and genomic maps detailing how various beta cell genes are regulated. (ucsd.edu)
Now, new research published in Stem Cell Reports has been able to promote the generation of rat sperm in a sterile mouse by injecting them with pluripotent stem cells (PSCs). (iflscience.com)
We were surprised by the relative simplicity by which we could mix the two species to produce viable mouse-rat chimeras," said senior author and stem cell biologist at ETH Zurich Ori Bar-Nur in a statement . (iflscience.com)
That said, the achievement represents a novel method for generating species' gametes which could prove useful in conservation, as well as wider stem cell research. (iflscience.com)
In its race to advance assisted reproduction and stem cell associated technologies to save the northern white rhinoceros from extinction, the BioRescue consortium announces a major breakthrough: the creation of primordial germ cell-like cells (PGCLSs) from induced pluripotent stem cells of the northern white rhino Nabire. (izw-berlin.de)
In the long term, the knowledge about C3 can be used to develop new treatments aimed at protecting the insulin-producing cells, such as stem cell therapies for treating type 1 diabetes and type 2 diabetes. (lu.se)

After four to five days of culture, the B cells started producing the IgA antibody in a process called "IgA class switch recombination. (sciencedaily.com)
In order to measure ER stress in cell lines engineered for high-levels of recombinant protein production, this research aims to demonstrate the presence of ER stress associated with immunoglobulin G (IgG) antibody production, elucidate the progression of UPR in response to highly producing recombinant protein, and determine the effect of UPR on product quality. (aiche.org)
The nanobodies are small antibody proteins naturally produced in specific animals like camels, alpacas, and llamas. (lawbc.com)
The premise for this vaccine concept rests on (i) the significance of CD4+ T cell memory space to influenza immunity, (ii) the essential role CD4+ T cells perform in development of neutralizing antibodies, (iii) linked specificity of HA-derived CD4+ T cell epitopes to antibody reactions, (iv) the structural plasticity of HA and (v) an illustration of improved antibody response to a prototype manufactured recombinant H7-HA vaccine. (fabretp.org)
Relative Mouse monoclonal to CDC2 to seasonal influenza, vaccination against avian influenza poses a unique challenge because the human population is definitely immunologically na?ve.17 Vaccination cannot rely on preferential recruitment of memory space B and T cells to elicit a protective antibody response due to Diethyl aminoethyl hexanoate citrate distant sequence relatedness with seasonal influenza. (fabretp.org)
Any cross-reactive memory space B and T cells would be present at frequencies too low to confer protecting antibody immunity by seasonal vaccination.18 As a consequence, avian influenza vaccines require higher doses than seasonal vaccines or adjuvant formulation to stimulate. (fabretp.org)

Cell surface sensors on immune cells that ordinarily recognize pathogen-associated molecular patterns produced by infectious agents may also interact with DAMPs, leading to the activation of signaling pathways resulting in a nonpathogen-induced 'sterile' inflammatory response. (nature.com)
In type 1 diabetes, immune cells called "T cells" begin to kill off the beta cells and blood glucose levels start to creep up. (medicalxpress.com)

When applied to cultured dopamine-producing neurons, the toxin caused mitochondria to stop trafficking along the axon within about 30 minutes, although other axonal transport systems continued to function. (genengnews.com)
While the specificity for dopamine-producing neurons has still to be worked out, a clue may lie in the team's observation that in comparison with other types of nerve cells, mitochondria in this type of neuron are smaller in size and travel three times more slowly. (genengnews.com)
Currently, simple end-stopped and complex end-stopped cells are the terms of choice to describe neurons with end-stopping properties. (wikipedia.org)
Investigations into the localization of function as well as the advent of single-cell recordings of neurons fostered greater insights into the processing of information from sensation to perception. (wikipedia.org)

In the case of the white rhinoceroses, Hayashi is working in close cooperation within BioRescue with Sebastian Diecke's Pluripotent Stem Cells Platform at the Max Delbrück Center and with reproduction experts Thomas Hildebrandt from Leibniz-IZW, both of them last authors of the paper, and Cesare Galli from Avantea. (izw-berlin.de)
Because PGCs are the founder population for gametes, this accomplishment paves a way to produce functional gametes from induced pluripotent stem cells from northern white rhinos which will contribute to the effort to rewind their extinction. (izw-berlin.de)

The aim of this study, was to assess whether pre-transplant donor-reactive T cells and/or B cells are associated with increased rejection risk. (eur.nl)
The number of donor-reactive IFN-γ and IL-21 producing cells was analyzed by ELISPOT assay. (eur.nl)
Numbers of donor-reactive IFN-γ producing cells were similar in patients with or without AR whereas those of IL-21 producing cells were higher in patients with AR (p = 0.03). (eur.nl)
Aside from an advanced donor-age and pre-transplant DSA, also pre-transplant donor-reactive IL-21 producing cells are associated with the development of AR after transplantation. (eur.nl)

Such optogenetic approaches utilizing light-activatable proteins for modulating the function of cells are being explored in many biological systems and have fueled efforts toward the development of a new genre of treatments. (newswise.com)
In this prototype solar cell, photosynthetic proteins (spheres embedded in yellow peptides) absorb light and pump electrons (e-) into a silver electrode. (sciencenews.org)
To make the solar cell, a team of biologists and engineers led by Marc Baldo of the Massachusetts Institute of Technology (MIT) harvested photosynthetic proteins from spinach and the bacterium Rhodobacter sphaeroides and deposited the proteins onto a glass support. (sciencenews.org)
Because the proteins naturally reside in an aqueous environment inside a cell membrane, it took some creative chemistry to keep the approximately 2 billion isolated proteins functional on a solid surface. (sciencenews.org)
The immune system produces a complex range of proteins and chemicals to protect against infections, allergies and cancer. (sciencedaily.com)
One group of these proteins is called immunoglobulins, or antibodies, that are produced by specialized cells called B cells. (sciencedaily.com)
As a result, accumulation of improperly folded proteins is a particularly challenging bottleneck in cell line engineering. (aiche.org)
It is expected research in this area will lead to improved engineering strategies for developing cell lines for higher titers of desired recombinant proteins, including relevant therapeutic protein products. (aiche.org)
We identified 231 proteins released from actomyosin contraction-dependent blebs and apoptotic bodies by adapted SILAC (stable isotope labeling with amino acids in cell culture) combined with mass spectrometry analysis. (nature.com)
In order for them to be developed from stem cells, they need a very specific environment in which signals from hormones or proteins trigger the required morphological and functional transformation. (izw-berlin.de)
Ricin works by getting inside the cells of a person's body and preventing the cells from making the proteins they need. (cdc.gov)
Without the proteins, cells die. (cdc.gov)

Therefore, although S7 cells are not fully equivalent to mature beta cells, their capacity for glucose-responsive insulin secretion and rapid reversal of diabetes in vivo makes them a promising alternative to pancreatic progenitor cells or cadaveric islets for the treatment of diabetes. (nih.gov)
In this study, we analyzed whether deoxysphingolipids directly compromise the functionality of insulin-producing Ins-1 cells and primary islets. (uzh.ch)

We have found a promising technique for type 1 diabetics to restore the body's ability to produce insulin. (press-news.org)

The physically bigger cells should store five times more energy than the currently used 2170-type cells. (insideevs.com)
Assuming 4416 2170-type cells in a Tesla Model Y Long Range, the MIT Model Y might get the same capacity using less than 900 4860-type cells. (insideevs.com)
A small new automotive customer is also Rivian (cylindrical cells - 2170 type). (insideevs.com)

Here, we investigate its transformation potential using organoids from primary murine colon epithelial cells. (uni-muenchen.de)
Activation of MAP kinases by hexavalent chromium, manganese and nickel in human lung epithelial cells. (cdc.gov)

Additional characterization using single-cell imaging and dynamic glucose stimulation assays revealed similarities but also notable differences between S7 insulin-secreting cells and primary human beta cells. (nih.gov)
After repeated stimulation, CD4 + T cells which were stimulated in the absence of costimulation through CD28 lost their ability to secrete IL-2 and started secreting IL-4 and IFN-γ. (karger.com)
With reference to vision, Stephen Kuffler discovered areas of the retina, termed receptive fields, that upon stimulation, would influence the firing of ganglion cells. (wikipedia.org)

They showed substantial effectiveness in producing antibodies against COVID-19 without any visible side effects. (medicaldaily.com)

In type I diabetes, the beta cells, which are the only cells in the body that produce insulin, are destroyed by the immune system resulting in complete lack of the hormone. (newswise.com)
Current treatments include the administration of drugs that enhance the production of insulin by pancreatic beta cells, or direct injection of insulin to supplement the naturally produced supply. (newswise.com)
Pancreatic beta cells were engineered with a gene that encodes a photoactivatable adenylate cyclase (PAC) enzyme. (newswise.com)
we just boost the amount of cAMP transiently in beta cells to get them to make more insulin only when it's needed. (newswise.com)
Insulin, a hormone that regulates blood sugar, is made in pancreatic beta cells. (umassmed.edu)
When insulin demand in the body exceeds beta cell insulin production capacity, prompted by events such as beta cell loss (type 1 diabetes) or weight gain (type 2 diabetes), beta cells proliferate in an effort to meet insulin demand. (umassmed.edu)
Until now, it was unclear how beta cells sense the demand to make more insulin. (umassmed.edu)
Although it was previously known that too much ER stress is bad for beta cells, causing them to die, our study found that a modest amount of stress is actually good for them, because it provides pressure to increase beta cell number to produce more insulin and keep blood sugar regulated," Dr. Alonso said. (umassmed.edu)
Importantly, the study also found that the key elements of this pathway are active in human beta cells too. (umassmed.edu)
According to Alonso, these results explain why beta cells are so sensitive to stress-they need to sense stress in order to determine how many beta cells are needed. (umassmed.edu)
Only fully mature insulin-producing beta cells are able to use this stress mechanism to sense that the body needs more insulin than the current allotment of beta cells can provide. (umassmed.edu)
For years, Annes' goal has been to develop a medication that would promote the regeneration of insulin-producing beta cells. (stanford.edu)
That advance might have given new hope to diabetes patients, but there was a catch: The way to get beta cells to start dividing and replicating is the same way to get lots of other cells to divide and replicate. (stanford.edu)
But Annes reasoned that if he could somehow get a regenerative drug to seek out zinc, he could get it to beta cells. (stanford.edu)
Annes, Horton and Smith aimed to use a zinc-chelating agent, which will bond to zinc wherever it runs into it, to deliver a drug to zinc-loving cells, but first they needed to see whether the chelating agent itself would accumulate in beta cells. (stanford.edu)
After initial lab tests showed it did, they attached a beta-cell regenerating drug to the zinc-chelating agent, and found that the drug would also build up in beta cells in a lab dish. (stanford.edu)
The team also showed that its zinc-chelation approach amassed more of the drug in beta cells than other cell types. (stanford.edu)
We plan to develop a roadmap of genetic variations, relevant in beta cells, to predict changes in insulin output - important information that may better enable us to prevent and treat diabetes," said team lead Maike Sander, MD, professor and director of the Pediatric Diabetes Research Center at UC San Diego School of Medicine. (ucsd.edu)
Beta cells produce the hormone insulin in response to increased sugar levels in the blood, as happens after a meal. (ucsd.edu)
In type 1 diabetes, a person's own immune system mistakenly attacks beta cells, so they don't produce insulin. (ucsd.edu)
It's a careful balance, though - if beta cells produced too much insulin, there would be too little blood sugar left to keep a person alive. (ucsd.edu)
Beta cells (green) produce the hormone insulin. (medicalxpress.com)
Perhaps unsurprisingly, their beta cells then function very differently than the cells do in people with normal blood glucose levels. (medicalxpress.com)
In a paper recently published in Molecular Metabolism , Weir's lab laid out a wealth of new data about how beta cells behave at slightly raised levels of blood glucose. (medicalxpress.com)
Studying beta cells in lab rats whose blood glucose levels were slightly elevated, Weir's lab found changes in gene expression that affect not just how well the cells function but their ability to divide and grow, as well as their vulnerability to autoimmunity and inflammation. (medicalxpress.com)
So virtually all the beta cells don't respond to that acute stimulus. (medicalxpress.com)
In earlier research, Weir and collaborators studied this phenomenon in rats who were surgically altered to generate slightly high blood glucose levels, and found that the rats' beta cells secreted less insulin. (medicalxpress.com)
In their latest experiments, the Joslin team employed the same approach along with powerful "RNA sequencing" methods that revealed patterns of gene expression in the beta cells, either four weeks or ten weeks after surgery. (medicalxpress.com)
As expected, genes involved in insulin secretion were highly active in the beta cells. (medicalxpress.com)
Some of these changes were related to cell growth-healthy beta cells may respond to increased blood glucose levels by copying themselves, but these cells were getting stuck as they tried to divide. (medicalxpress.com)
Weir's team found that in the rats with just slightly greater glucose levels, beta cells showed dramatic increases in the expression of some key genes involved in T cell interactions. (medicalxpress.com)
That effect could make the beta cells a better target for autoimmune attack, and thus speed the disease. (medicalxpress.com)
This finding may improve the understanding of the rapid death of beta cells that patients typically experience just before they are diagnosed with type 1 diabetes, Weir says. (medicalxpress.com)
During this period, if insulin treatments can bring the remaining beta cells back down to only slightly elevated glucose levels, the cells can function much better, he says. (medicalxpress.com)
Immunologists often blamed this loss on inflammation of the beta cells, but other studies have shown that less than half of these cells appear to suffer from inflammation. (medicalxpress.com)
So somehow these beta cells with no evidence of inflammation end up not secreting properly," Weir says. (medicalxpress.com)
Transplants of normal beta cells carry the risk of rejection or side effects from immunosuppressive therapies. (technologynetworks.com)
But whereas the former approach filled these needles with manmade bubbles of insulin, this new "smart cell patch" integrates the needles with live beta cells. (technologynetworks.com)
However, alpha cells do not normally become beta cells. (press-news.org)
The process of alpha cells converting to beta cells does not appear to have any age limitations-it occurred in young and old individuals-including some that had type 1 diabetes for decades. (press-news.org)
So our next step is to find out which molecule(s) caerulein is targeting on alpha cells that triggers their transformation into beta cells. (press-news.org)
In addition to creating new beta cells, another issue that needs to be addressed to achieve a cure for type 1 diabetes is that any new beta cells will be attacked by the autoimmune response present in every patient with type 1 diabetes. (press-news.org)
In type 1 diabetes, the immune system destroys insulin-producing pancreatic beta cells. (medscape.com)

Our study shows that we can use sterile animals as hosts for the generation of germ cells from other animal species," said Bar-Nur. (iflscience.com)

Tesla celebrates a milestone of producing one million 4680-type cylindrical lithium-ion battery cells. (insideevs.com)
Let's recall that Volkswagen Group intends to build (with partners) a total of six lithium-ion battery cell plants in Europe alone, with a total output of about 240 GWh annually (40 GWh per plant on average). (insideevs.com)

Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that occurs when a person's immune system attacks healthy cells in the body. (medicaldaily.com)

Additionally, the cells showed many differences in the expression of genes involved in cell inflammation and autoimmunity. (medicalxpress.com)
Different cell types and their highly expressed genes through single-cell transcriptomic analysis. (elifesciences.org)
B ) Heatmap shows the scaled expression patterns of the top 10 marker genes in each cell type. (elifesciences.org)
C ) Violin plots showing the expression of representative well-known and potential new marker genes of the four subtypes of adrenal cell types. (elifesciences.org)
C ) Overlap of upregulated or downregulated genes in the two pairwise comparisons between adrenal cell types. (elifesciences.org)

Although the prototype device can't yet rival commercial solar cells made of silicon, it demonstrates a new strategy for making longer-lasting photovoltaic cells. (sciencenews.org)
Foxconn's acquisition of Sharp boosts its capabilities to produce solar power and high end smartphone displays. (nextbigfuture.com)
The Chinese solar module producer says it has achieved 21.1% average efficiency for P-type monocrystalline PERC cells produced in industrial standard conditions. (pv-magazine.com)
Trina Solar, the Chinese Tier-1 solar company, has announced this week that it has achieved a new record efficiency for PERC solar cells. (pv-magazine.com)
We are proud of our latest achievement in attaining an average conversion efficiency rate of 21.1% for our monocrystalline PERC cells that were industrially produced by applying our laboratory world record PERC cell technology,' said Trina Solar s VP and chief scientist, Pierre Verlinden. (pv-magazine.com)
As demand for high-efficiency cells increases,' Feng said, 'our R&D team s achievement in raising the average efficiency of our industrially produced mono PERC cells will help accelerate the applications of high-efficiency solar products and build a solid foundation for further reductions in the LCOE. (pv-magazine.com)
As part of the READY project, three of Ringgården's six apartment blocks on Trige Parkvej are currently being fitted with a very special energy solution, a new type of photovoltaic installation that can produce around three times as much energy as traditional solar cells. (dbdh.dk)
Where traditional solar cells can absorb about 20 per cent of the energy in sunlight, the new PTVT panels can absorb up to 90 per cent. (dbdh.dk)
That is why we have worked with to develop a smart battery installation which can store the surplus energy from the solar cells and make it available when residents come home and need electricity and heat. (dbdh.dk)

The PAC produces the molecule cyclic adenosine monophosphate (cAMP) when exposed to blue light, which in turn cranks up the glucose-stimulated production of insulin in the beta cell. (newswise.com)
What's surprising is that the changes in beta-cell behavior begin to occur when the blood glucose levels are barely elevated, still within the pre- diabetes range. (medicalxpress.com)
These slightly high concentrations of glucose are enough to really confuse the cell," says Gordon Weir, MD, senior investigator and senior staff physician at Joslin Diabetes Center. (medicalxpress.com)
Fortunately, the cells eventually do wake up and respond to other stimuli well enough to keep blood glucose in a prediabetic range. (medicalxpress.com)
Plus it demonstrates that we can build a bridge between the physiological signals within the body and these therapeutic cells outside the body to keep glucose levels under control. (technologynetworks.com)
Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy. (medlineplus.gov)
Without insulin, cells cannot take in glucose. (medlineplus.gov)
The cells, unable to use the glucose in the blood for energy, respond by using fats instead. (medlineplus.gov)

The 4680-type cylindrical cells (combined with a structural battery pack) will be used in new electric vehicles from Tesla, starting with the Made-in-Texas (MIT) Model Y . (insideevs.com)

Stem cells are cells that are not differentiated - that is, they have not acquired a particular type (such as lung cells, or blood cells). (sciencedaily.com)

Genotoxic colibactin-producing pks+ Escherichia coli induce DNA double-strand breaks, mutations, and promote tumor development in mouse models of colorectal cancer (CRC). (uni-muenchen.de)
A unique tumor cell type was revealed by the composition analysis of cell types in each sample. (elifesciences.org)
Cellular immunity, particularly of CD4 + T cells, IFN-γ and tumor necrosis factor (TNF)-α, has a central role in the control of and protection against Mycobacterium tuberculosis (MTB) infection ( 1 ). (atsjournals.org)

and despite the increased secretion of insulin, the amount of oxygen consumed by the cells does not change significantly as our study shows. (newswise.com)
They'll look at 10 different stimuli known to modify insulin secretion, including sugar, other nutrients and food-dependent hormones, and determine how the beta cell genome and insulin release change in response to those stimuli over various lengths of time. (ucsd.edu)
however , secretion levels needed for industrial cell lines likely leads to an imbalance in ER homeostasis, resulting in increased cellular stress. (aiche.org)
Blocking of endogenous IL-4 activity with anti-IL-4 Ab suppressed the IL-4 secretion and prolifeation of T cells. (karger.com)

Scientists in Italy and Texas now have discovered a new way that these cells die - by toxic imbalance of a molecule secreted by other pancreatic cells. (medicaldaily.com)

More striking were newly discovered alterations in gene expression that could make the cells more vulnerable. (medicalxpress.com)
A ) Volcano plot of changes in gene expression between POMC+&CRH + pheochromocytes and other adrenal cell types (pheochromocytes and adrenocortical cells). (elifesciences.org)
The present invention further relates to mutants cells comprising a marker-free modification of a gene, and methods for obtaining and using such mutant cells. (justia.com)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)

Scientists have used a synthetic form of a recreational heroine-like drug developed back in the 1980s to demonstrate that dopamine-producing nerve cell death caused by Parkinson disease may be due to mitochondrial damage. (genengnews.com)
Overall, only about 33% of Hürthle cell tumors demonstrate signs of that invasive growth that indicates malignancy and the possibility of metastasis. (medscape.com)

Instead, the activated follicles eventually produced oocytes , the precursors of egg cells, which seemed normal in every important respect. (nationalgeographic.com)
Crucial to embryo production is the availability of oocytes (egg cells) and sperm. (izw-berlin.de)

The study found ER stress pathways actually send a signal to the cell nucleus, via an ER protein called ATF6 that says "proliferate. (umassmed.edu)
In normal ovaries, the unleashed PI3K targets a protein called Foxo3, which is then removed from the nucleus of follicle cells. (nationalgeographic.com)
We already have many examples ure of a discrete action (lever press) to in the sensitivity of nucleus accumbens of how brain biology can affect behav- produce the expected results (cocaine). (lu.se)

Sequencing the human genome - a feat accomplished in 2003 - provided the list of ingredients that make up a human being, but not the instructions that explain how those ingredients are used by each cell type to create complex "meals. (ucsd.edu)
The effects of the wild type bacteriurn, several mutants and the purified factors will be tested on Arabidopsis plants as well as tobacco cell cultures. (europa.eu)
We expect to discover which type of cells are targets for Rhodococcus and where these cells are located in the plant. (europa.eu)
The company says that it has reached 21.1% average efficiency for its P-type monocrystalline cells with passivated emitter and rear cell (PERC) technology, produced in standard industrial conditions on a cell measuring 156 x 156 mm2 and reaching an output power of 300 watts (W). (pv-magazine.com)
The study, published online July 31 in Cell Death and Disease, suggests a new approach to treating the estimated 3 million people in the U.S., and over 300 million worldwide, living with type 1 diabetes. (press-news.org)
In a report appearing in the August 2014 issue of the Journal of Leukocyte Biology, one of the most important blood cells involved in the human immune response, B cells, are shown to promote inflammation and bone loss in type 2 diabetes-associated periodontal disease. (press-news.org)
Although there are many differences between type 1 diabetes and type 2 diabetes, there are also similarities, such as inflammation of the insulin-producing cells. (lu.se)
Breaking down fats to obtain energy produces waste products called ketones, which can build up to toxic levels in people with type 1 diabetes, resulting in diabetic ketoacidosis. (medlineplus.gov)
Most people with diabetes have type 2 diabetes , in which the body continues to produce insulin but becomes less able to use it. (medlineplus.gov)
A hypercomplex cell (currently called an end-stopped cell) is a type of visual processing neuron in the mammalian cerebral cortex. (wikipedia.org)
The drug α-difluoromethylornithine (DFMO) may help preserve beta-cell function in people with new-onset type 1 diabetes , new preliminary data suggest. (medscape.com)
As yet, no agent has been approved for preserving beta-cell function after the onset of type 1 diabetes, but many are under investigation. (medscape.com)
The new safety study by Sims and colleagues, which was published November 1 in Cell Medicine Reports , enrolled 41 people with type 1 diabetes that had been diagnosed within the previous 8 months, including 31 children. (medscape.com)
Hürthle cell carcinoma of the thyroid gland is an unusual and relatively rare type of differentiated thyroid cancer. (medscape.com)

The cell body also has fewer connections to other cells, and it needs those connections to survive. (genengnews.com)
The human body contains approximately ten times as many bacterial cells as human cells. (sciencedaily.com)
Dying cells have been defined as apoptotic by distinguishing features, including cell contraction, nuclear fragmentation, blebbing, apoptotic body formation and maintenance of intact cellular membranes to prevent massive protein release and consequent inflammation. (nature.com)
In addition to maintenance of membrane integrity, apoptotic cells can be discriminated from viable counterparts based on several morphological hallmarks, including cell contraction, nuclear condensation and fragmentation, and actomyosin contraction-dependent membrane blebbing and apoptotic body formation. (nature.com)
A chimera is defined as an animal whose body is made up of cells that are genetically distinct from one another. (iflscience.com)
Our next step is to find out more about how we can vary the size of the embryoid body by changing the printing and structural parameters, and how the varying the embryoid body size leads to "manufacture" of different cell types " adds Rui Yao, another author on the paper. (phys.org)
This also includes a migration of the cells in the body (PGC migration). (izw-berlin.de)
it's a pigment that your body produces as a by-product of recycling blood cells. (cdc.gov)

Blood samples must be processed within 8-30 hours after collection while white blood cells are still viable. (cdc.gov)
Confirm arrangements for testing in a qualified laboratory, and arrange for delivery of the blood sample to the laboratory in the time the laboratory specifies to ensure testing of samples with viable blood cells. (cdc.gov)

These patients had a markedly decreased cytokine production and expressed low levels of T cell receptor CD3ζ chain. (aacrjournals.org)

A ) Cell clusters shown in UMAP map can be subdivided by different specimens. (elifesciences.org)
A monomorphous cell population of Hürthle cells arranged in loosely cohesive clusters and single cells. (medscape.com)

In healthy people, they produce, store, and release the hormone insulin to help process sugar that builds up in the bloodstream after a meal. (technologynetworks.com)

Sanford-Burnham takes a collaborative approach to medical research with major programs in cancer, neurodegeneration and stem cells, diabetes, and infectious, inflammatory, and childhood diseases. (press-news.org)
It has long been known that C3 plays a crucial role for the immune system in the bloodstream where it helps white blood cells to engulf infectious microorganisms. (lu.se)

Inhibition of intracellular 1-deoxysphinganine trafficking and ceramide synthesis improved the viability of the cells, indicating that the intracellular metabolites of 1-deoxysphinganine contribute to its cytotoxicity. (uzh.ch)
If we can increase the production of intracellular C3 in these cells, it may help the cells survive longer so that the treatment can be more effective," says Ben C King, associate professor of inflammation research at Lund University, and co-senior author of the study. (lu.se)
Intracellular cAMP, the production of which is catalyzed by the α-subunit of the stimulatory G protein (Gsα), controls renin synthesis and release by juxtaglomerular (JG) cells of the kidney , but may also have relevance for the physiologic integrity of the kidney . (bvsalud.org)

Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. (lu.se)
More and more data have demonstrated that several Th subsets, such as Th1 cells ( 3 ), Th17 cells ( 4 ), regulatory T cells ( 5 ), and so on, are involved in the pathogenesis of TPE. (atsjournals.org)

Irreversible failure of pancreatic β-cells is the main culprit in the pathophysiology of diabetes mellitus, a disease that is now a major global epidemic. (uzh.ch)

Highly functional titania nanoparticles produced by flame spray pyrolysis. (forth.gr)

American Journal of Respiratory Cell and Molecular Biology , 64 (1), 143-146. (eur.nl)

To maintain that high a sperm output, you need many functioning stem cells. (sciencedaily.com)
In the adult testicles, the germ stem cells can produce more germ stem cells, but can also produce daughter cells that go on to become sperm. (sciencedaily.com)
The second surprise was that indeed all the sperm cells inside the chimeras were of rat origin. (iflscience.com)
As such, the mouse host environment, which was sterile due to a genetic mutation, was still able to support efficient sperm cell production from a different animal species. (iflscience.com)
The achievement demonstrates that it's possible to get a sterile animal to create the sperm cells of a different species, but it wasn't perfect. (iflscience.com)

The present invention also relates to mutants of filamentous fungal cells and methods for obtaining the mutant cells. (justia.com)

The light-switchable cells are designed to compensate for the lower insulin production or reduced insulin response found in diabetic individuals. (newswise.com)
When there's an increase in insulin demand, there's a corresponding increase in insulin production in the endoplasmic reticulum (ER) of the beta cell, which causes some stress to the ER system. (umassmed.edu)

To help bridge the gap between genotype (DNA sequence) and phenotype (cell behavior), the National Human Genome Research Institute, part of the National Institutes of Health, has launched a new Impact of Genomic Variation on Function Consortium . (ucsd.edu)
Notably, PDE inhibition also enhanced the enrichment of human Foxp3(+) CD4(+) T cells driven by allogeneic APCs. (lu.se)
10 9 apoptotic events occurring per day in human adult tissues, it is surprisingly difficult to histologically detect apoptotic cells due to the rapid recognition and clearance of apoptotic cells. (nature.com)
The objectives of this study were to better characterize the cells and mechanisms involved in depositing apatite crystals in human tendons. (iasp-pain.org)
On November 30, 2022, the U.S. Department of Agriculture's (USDA) Agricultural Research Service (ARS) announced that its scientists have determined that plants could be used to produce nanobodies that quickly block emerging pathogens in human medicine and agriculture. (lawbc.com)
The smoke may contain ultra-fine particles, toxic compounds (e.g., benzene, toluene, hydrogen cyanide), viruses (e.g., human papilloma virus [HPV]), and cancer cells (Guideline for Surgical Smoke Safety). (cdc.gov)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

One promising approach may be to stimulate the regeneration of those cells with drugs. (stanford.edu)

The distribution and phenotypic features of Th22 cells in both TPE and blood were determined. (atsjournals.org)
Th22 cells were significantly higher in TPE than in blood. (atsjournals.org)
The protein is secreted from cells and is found in large quantities in the blood. (lu.se)
White blood cells from most persons that have been infected with M. tuberculosis will release interferon-gamma (IFN-g) when mixed with antigens (substances that can produce an immune response) derived from M. tuberculosis . (cdc.gov)

Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage. (bvsalud.org)

Pancreas19

Embryonic stem7

Dendritic cells9

Differentiation12

Mononuclear cells2

Researchers31

Enough insulin3

Proliferation4

Vitro7

Tissue7

Naive CD41

Differentiate4

Mice17

Antigen-prese1

Stem cell9

Antibody6

Immune cells2

Neurons4

Pluripotent Stem2

Donor-reactive4

Proteins12

Islets2

Body's1

2170-type3

Epithelial cells2

Stimulation3

Antibodies1

Beta cells43

Germ cells1

Lithium-ion bat2

Person's1

Genes5

Solar9

Glucose8

Cylindrical cells1

Lung1

Tumor3

Secretion4

Molecule1

Gene4

Demonstrate2

Oocytes2

Nucleus3

Type14

Body8

Viable2

Cytokine production1

Clusters2

Hormone1

Infectious2

Intracellular3

Regulatory T cel2

Diabetes Mellitus1

Functional1

Molecular Biology1

Sperm5

Mutants1

Insulin production2

Human7

Regeneration1

Blood4

Leads1