Cells other subsets. Medical search. Frequent questions

Rather, using multidimensional cytometry, transcriptomics, and functional assays, we define a population of PD-1 hi CXCR5 − 'peripheral helper' T (T PH ) cells that express factors enabling B-cell help, including IL-21, CXCL13, ICOS, and MAF. (nature.com)
Therefore, in this study, we investigated the expression of three immune checkpoints on peripheral blood DC subsets, in basal conditions and upon exposure to pro-inflammatory and anti-inflammatory stimuli, by using a flow cytometric panel that allows a direct comparison of the activatory/inhibitory phenotype of DC-lineage and inflammatory DC subsets. (nih.gov)
A ) Representative plot shows that human NKp46 + NKT cells (CD56 + CD3 + ) in peripheral blood of healthy donors represented approximately 1.5% of NKT cells and approximately 0.2% of human lymphocytes (data not shown). (jci.org)
Porcine peripheral blood lymphocytes were stained with Mouse Anti-Porcine B Cell Subset-PE (SB Cat. (southernbiotech.com)
The monoclonal antibody BB6-10A10 stains the following percentages of surface immunoglobulin (sIg) positive cells in porcine lymphoid tissues - 11-15% in peripheral blood, 22-23% in mesenteric lymph nodes, 79-87% in ileal Peyer's patches (ILPP), 6-17 in spleen, and 0% in thymus. (southernbiotech.com)
Porcine peripheral blood lymphocytes were stained with Mouse Anti-Porcine B Cell Subset-BIOT (SB Cat. (southernbiotech.com)
Since some human immune cell subsets express PD-L1 on their surface, studies were undertaken to evaluate changes in the frequency of immune cell subsets in peripheral blood mononuclear cells (PBMC) from cancer patients pre- vs post-treatment with Avelumab. (bmj.com)
The detection of GC B cells within blood led to the postulation of the "recirculation" hypothesis, which states that a fraction of GC B cells exits the GCs and enters the peripheral blood without losing the GC B cell phenotype. (fu-berlin.de)
Indeed, different DC subsets are distributed in peripheral tissues and the blood and display different microbial receptors, surface molecules and cytokine expression, all of which influence the immunologic outcome. (elsevierpure.com)
The elements were evaluated by the total number of peripheral leukocyte, granulocyte and lymphocyte ratio and lymphocyte subsets. (scirp.org)
Peripheral blood phenotyping data show increases in CD4+ and CD8+ T cell proliferation two weeks after anti-OX40 administration. (bepress.com)
1 Significant advances have been made by combining novel agents with autologous peripheral blood stem cell transplantation which allows for long-term disease-free survival in the majority of transplant-eligible patients. (haematologica.org)

We further demonstrated that similar to non-lymphoid dendritic cells (DCs), CD103(+) LCs originate from pre-DCs, whereas CD11b(+) LCs differentiate from both pre-DCs and monocytic precursors. (nih.gov)
Dendritic cells (DCs) play a crucial role in initiating and shaping immune responses. (nih.gov)
plasmacytoid dendritic cells. (nih.gov)
Immune cells evaluated were PD-L1 positive and PD-L1 negative subsets of the following: CD4+ T cells, CD8+ T cells, NK cells, regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSC), natural killer T cells (NKT), plasmacytoid dendritic cells (DC), conventional DC, and B cells. (bmj.com)
Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
Dendritic cells (DCs) orchestrate a repertoire of immune responses that endows resistance to infection and tolerance to self. (elsevierpure.com)

In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
T cells represent the major component of tumor infiltrating lymphocytes (TIL) in TGCT. (uni-giessen.de)
HIV infection is characterized by a decrease and, eventually, a depletion of CD4+ T-lymphocytes (helper T cells). (cdc.gov)
Using immunophenotyping, HIV-positive blood samples and age-matched controls were tested for the proportion of lymphocytes that are T cells, B cells, natural killer (NK) cells, CD4+ T cells (helper T cells), and CD8+ T cells (suppressor/inducer T cells). (cdc.gov)
Accurate and reliable measures of CD4+ T-lymphocytes (CD4+ T-cells) are essential to the assessment of the immune system of human immunodeficiency virus (HIV)-infected persons (1-3). (cdc.gov)
and the percentage of lymphocytes that are CD4+ T-cells. (cdc.gov)
The CDC guidelines concerning CD4+ T-cell determinations (33) were first published in the MMWR in 1992 to provide laboratorians with the most complete information about how to measure CD4+ T-lymphocytes in blood from HIV-infected persons by using flow cytometry. (cdc.gov)
about 75% of the lymphocytes are T cells, 20% B cells, and 5% NK cells. (msdmanuals.com)
Because lymphocytes account for only 20 to 40% of the total white blood cell (WBC) count, lymphocytopenia may go unnoticed if the WBC count is checked without a differential. (msdmanuals.com)
Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)

Finally, a number of biologics that target CD4 + T cell differentiation into inflammatory subsets or their byproducts (i.e., cytokines) have shown efficacy in treating patients with IBD ( 5 - 7 ). (frontiersin.org)
Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)
STAT4 also signals activation of the TF T-bet, a lineage-defining factor for Th1 differentiation, which upregulates the IL-12 receptor, IFN-γ expression, and causes further expansion of Th1 cells (Figure 1 ) ( 12 ). (frontiersin.org)
Critical factors in the differentiation of effector Th cells during inflammatory bowel disease (IBD). (frontiersin.org)
CD80/86-CD28 interaction and others), these signals initiate a program of cell division and differentiation. (frontiersin.org)
Interleukin (IL)-12 and IL-23, cytokines induced during early stages of IBD, play important roles in differentiation of interferon (IFN)-γ/tumor necrosis factor (TNF)-producing Th1 cells as well as IL-17-producing Th17 cells. (frontiersin.org)
Figure 4: PD-1 hi CXCR5 − CD4 + T cells promote plasma cell differentiation through IL-21 and SLAMF5 interactions. (nature.com)
The cancer cells that emerge are referred to as blasts and share biological features from these disease-specific alterations and patterns associated with differentiation and the tumor cell of origin. (uni-heidelberg.de)
Both tumor entities harboring FLT3-ITDs or IDH1 mutations showed a more complex composition of cell types along the myeloid differentiation trajectory than MLL fusions. (uni-heidelberg.de)
This indicates a partial differentiation of AML cells that treatment might induce. (uni-heidelberg.de)
SCC of the prostate is a rare malignant epithelial neoplasm arising in the prostate, with squamous differentiation of the neoplastic cells. (medscape.com)
The localization and differentiation status of the donor B cells within spleen, bone marrow and mesenteric lymph nodes of recipients were determined during one week after transfer via flow cytometry and immunofluorescence microscopy. (fu-berlin.de)
These models describe various mechanisms for the differentiation of naïve T-cells into memory, either sequentially, or via specific cell subsets. (flowmetric.com)
ScRNA-seq revealed the diversity of cell differentiation and the unique information of cell subpopulations in the cortex of rats with acute ischemic stroke , providing novel insight into the pathological process and drug discovery in stroke . (bvsalud.org)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

Two distinct subsets of BTICs were identified co-existing in human glioblastoma, both in de novo tumors and in recurrent tumors after initial complete surgical resection and chemoradiation. (cns.org)
Although myofibroblasts have been considered the only phenotype of activated fibroblasts, distinct subsets of fibroblasts, namely inflammatory fibroblasts and myofibroblasts, have been reported in arthritis and pancreatic cancer. (kcl.ac.uk)

We demonstrated that functionally distinct DC subsets are characterized by differential expression of activatory and inhibitory molecules, and that cDC1s in particular are endowed with a unique immune checkpoint repertoire characterized by high TIM-3 expression, scarce PD-L1 expression and lack of ILT2. (nih.gov)
Collectively, our data demonstrate that NKp46 identifies a functionally distinct NKT subset in mice and humans that appears to be directly susceptible to leukemic transformation when IL-15 is overexpressed. (jci.org)
Functionally, UCHL1 identifies a subpopulation of T cells which proliferates maximally to soluble antigen and provides maximum help for PWM-stimulated immunoglobulin synthesis. (ox.ac.uk)

T PH cells appear to be uniquely poised to promote B-cell responses and antibody production within pathologically inflamed non-lymphoid tissues. (nature.com)
Preclinical studies have shown that resveratrol induces immunomodulatory effects, including the upregulation of NKG2D receptors on natural killer cells (NK) that it promotes the NKG2D-dependent killing of tumor cells [ 13 , 14 ] and the induction of regulatory T cells (Treg) in the colonic tissues of mice exposed to colonic inflammatory stress [ 15 ]. (hindawi.com)
These cells can cause major damage to body tissues. (jle.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
4) RT-PCR profiler Arrays using stem cell (SC) panel of 84 genes for four group of cells (1) CD44 + /CD24 - /EpCAM - BCSCs, (2) CD44 + /CD24 - /EpCAM + BCSCs, (3) mammospheres, and (4) normal breast tissues. (harvard.edu)
Tissues in which cells select for the defective PORCN gene show anomalies. (medscape.com)

Given the importance of CD4 + Th cells in the disease process, this review will focus on how Th cells differentiate in the inflamed intestinal tract during IBD and how the Th lineage-specific cytokines and transcription factors (TFs) contribute to disease. (frontiersin.org)
Fully activated immunostimulatory DCs express high levels of costimulatory molecules, produce pro-inflammatory cytokines, and stimulate T cell proliferation, whereas tolerogenic DCs express low levels of costimulatory molecules, produce immunomodulatory cytokines and impair T cell proliferation. (nih.gov)
Resveratrol was safe and well tolerated and was associated with significant increases in the numbers of circulating γδ T cells and regulatory T cells and resulted in small, yet significant, decreases in the plasma levels of the proinflammatory cytokines TNF- α and MCP-1 and a significant increase in the plasma antioxidant activity compared with the corresponding antioxidant baseline activity and with that in four control individuals. (hindawi.com)
After antigen stimulation, these cells migrate into tissue areas that are inflamed where they exhibit a strong proliferative response and express and release cytokines that help to eliminate infection. (flowmetric.com)

The aim of the current study is to characterize the BCSCs through the genetic profiling of different BCSCs phenotypic subsets to determine their related genetic pathways. (harvard.edu)
In this review, we summarize the current knowledge on the different intracellular pathways involved in the programming of Treg cell homeostasis and functions in cancer. (mdpi.com)
Reviews of lung malignancies bearing mutations in the gene possess generated considerable curiosity because these mutations could be associated with elevated sensitivity to realtors directly concentrating on BRAF or BRAF mediated downstream signalling pathways (10 11 BRAF is normally a serine/threonine kinase that is situated downstream of RAS in the RAS-RAF-MEK-ERK signalling pathway an integral molecular cascade that regulates cell development. (bioerc-iend.org)
These results indicate that biological processes and signaling pathways are involved in different cell subpopulations. (bvsalud.org)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

Applied to the characterization of DCs in the tumor microenvironment, this panel has the potential to provide valuable information to be used for investigating the role of DC subsets in cancer, guiding DC-targeting treatments, and possibly identifying predictive biomarkers for clinical response to cancer immunotherapy. (nih.gov)
Sequencing methods that analyze the transcriptome (scRNA-seq) and epigenome (scATAC-seq) are ideally suited to resolve tumor cell heterogeneity as well as non-malignant cell types in the microenvironment. (uni-heidelberg.de)
I could demonstrate that leukemic cells could be successfully distinguished from the microenvironment based on marker gene annotation from the human cell atlas and ploidy inference. (uni-heidelberg.de)
Single-Cell RNA-Seq Reveals Changes in Cell Subsets in the Cortical Microenvironment during Acute Phase of Ischemic Stroke Rats. (bvsalud.org)

Cell type prediction revealed extensive malignant cell diversity and a phenotype skewed towards stem- and progenitor-like populations in MLL-EDC4 leukemic cells. (uni-heidelberg.de)
MLL fusions, except for MLL-EDC4, generally conferred a more differentiated phenotype predominantly consisting of monocytes/macrophage CD14-like and promonocyte-like cells. (uni-heidelberg.de)
The major finding of this work was the detection of B cells bearing a GC phenotype in blood. (fu-berlin.de)
Only approximately 40% of CD11c+ B cells displayed an atypical B cell phenotype, with the remaining cells primarily made up of activated and resting memory B cells. (jci.org)

The U.S. Food and Drug Administration (FDA) approved Rybrevant (amivantamab-vmjw) as the first treatment for adult patients with non-small cell lung cancer whose tumors have specific types of genetic mutations: epidermal growth factor receptor (EGFR) exon 20 insertion mutations. (hpnonline.com)
The relative abundance of different malignant cell types discovered varied amongst tumors, with some having just two identities and others having a wide range of malignant cells. (uni-heidelberg.de)
Fresh human glioblastoma tumors obtained directly from neurosurgical resections were immediately dissociated and passaged in neural stem cell media to enrich the subpopulation of tumor cells with stem-like properties. (cns.org)
In vitro and in vivo testing of purified BTIC subsets were performed to verify multipotency, self-renewal, and capacity to generate glioblastoma tumors in murine cranial xenotransplantation models. (cns.org)
The finding that both BTIC subsets were present in reproducible proportions across patients, and from both de novo and recurrent tumors, suggest these subpopulations are not differentially affected by current clinical interventions. (cns.org)
Given the high frequency of DDX5 amplification in breast cancer, our results highlight DDX5 as a promising candidate for targeted therapy of breast tumors with DDX5 amplification, and indeed we show that DDX5 inhibition sensitizes a subset of breast cancer cells to trastuzumab. (aacrjournals.org)
High intratumoral plasma cells content in primary prostate cancer defines a subset of tumors with potential susceptibility to immune-based treatments. (physiciansweekly.com)
Among immune cells, Foxp3 + regulatory T cells (Treg cells) are potent inhibitors of cancer immunity, and their presence within solid tumors is generally associated with a poor prognosis. (mdpi.com)
Treg and Tfh cells were most frequently detected in tumors, along with helper (CD4+) and cytotoxic (CD8+) T cells. (uni-giessen.de)
Adoptive transfer of expanded natural killer cells inhibited the growth of established OPM2 and high-risk primary myeloma tumors grown in the murine model. (haematologica.org)

2018 . DOI : 10.1016/j.cell.2018.01.028. (epfl.ch)

First, I characterized changes in the transcriptome and classified developmental stages of leukemic cells carrying MLL-EDC4 fusions along the hematopoietic stem cell to the myeloid trajectory compared to other MLL fusions. (uni-heidelberg.de)
While myeloid cells have been proposed to form those niches, the contribution by colocalizing stromal cells has remained unclear. (ox.ac.uk)
The UCHL1 determinant is also present on cells of the myeloid lineage, but not normal B cells or NK cells. (ox.ac.uk)

In this study, we analyzed HIV latency establishment in different CD4+ T cell subsets stimulated with interleukin 15 (IL-15), a cytokine that increases both susceptibility to infection and reactivation from latency. (unimi.it)
We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma. (haematologica.org)

abstract = "Pronounced circadian rhythms in numbers of circulating T cells reflect a systemic control of adaptive immunity whose mechanisms are obscure. (uni-luebeck.de)
abstract = "The discovery of cell type-specific markers can provide insight into cellular function and the origins of cellular heterogeneity. (northwestern.edu)

CD4 + T cells are enriched in lesional tissue from patients with CD and UC and blockade or depletion of CD4 + T is effective in treating patients with IBD. (frontiersin.org)
In these studies, CD4 + T cell-depleting and blocking antibodies caused remission from disease in a number of CD and UC patients examined, suggesting a prominent role of CD4 + T cells in propagating disease ( 1 , 2 ). (frontiersin.org)
Interestingly, IBD patients with concurrent HIV infection also exhibit a greater incidence of remission as compared to non-HIV controls, correlating with decreased total blood CD4 + T cell counts ( 3 , 4 ). (frontiersin.org)
Here we use mass cytometry to analyse activated T cells in joint tissue from patients with rheumatoid arthritis, a chronic immune-mediated arthritis that affects up to 1% of the population 2 . (nature.com)
This approach revealed a markedly expanded population of PD-1 hi CXCR5 − CD4 + T cells in synovium of patients with rheumatoid arthritis. (nature.com)
Figure 1: Expanded PD-1 hi CXCR5 − CD4 + T cells in joints and blood of patients with seropositive RA. (nature.com)
With today's approval, for the first time, patients with non-small cell lung cancer with EGFR exon 20 insertion mutations will have a targeted treatment option. (hpnonline.com)
Approximately 2% to 3% of patients with non-small cell lung cancer will have EGFR exon 20 insertion mutations, which are a group of mutations on a protein that causes rapid cell growth, and consequently, helps cancer spread. (hpnonline.com)
Researchers evaluated Rybrevant's efficacy in a study of 81 patients with non-small cell lung cancer and EGFR exon 20 insertion mutations whose disease had progressed on or after platinum-based chemotherapy. (hpnonline.com)
While immune cell subsets pre- vs post-treatment continue to be analyzed in various patient cohorts, these studies provide evidence that Avelumab, a fully human IgG1 MAb, capable of mediating ADCC, can be administered safely to cancer patients without altering the balance of numerous PBMC immune cell subsets. (bmj.com)
Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. (bepress.com)
Here we describe the results from a phase Ib clinical trial (NCT02274155) in which 17 patients with locally advanced head and neck squamous cell carcinoma (HNSCC) received a murine anti-human OX40 agonist antibody (MEDI6469) prior to definitive surgical resection. (bepress.com)
Analyses of CD8+ TIL show increases in tumor-antigen reactive, proliferating CD103+ CD39+ cells in 25% of patients with evaluable tumor tissue (N = 4/16), all of whom remain disease-free. (bepress.com)
Results Natural killer cells from healthy donors and myeloma patients expanded a median of 804- and 351-fold, respectively, without significant T-cell expansion. (haematologica.org)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
et 20 témoins en bonne santé ne présentant pas d'infection par le virus de l'hépatite C. Une réduction importante de la fréquence des cellules tueuses naturelles totales dans le groupe des patients porteurs d'une infection chronique a été observée par rapport au groupe des témoins ( P = 0,001) ou au groupe des patients dont l'infection a connu une résolution spontanée ( P = 0,01). (who.int)
of various populations of NKR+ T cells whole blood were withdrawn from Natural killer (NK) cells are potent have been reported to be impaired in each participant on ethylenediamine- antiviral cells which eliminate the vi- chronic hepatitis C patients [16,21]. (who.int)
Thus, most patients with lymphocytopenia have a reduced absolute number of T cells, particularly in the number of CD4+ T cells. (msdmanuals.com)

Subsequently, GO and KEGG analyses were performed on the top 40 differentially expressed genes (DEGs) in the six cell subpopulations with significant differences. (bvsalud.org)

PE Anti-Porcine B Cell Subset for use in flow cytometry assays. (southernbiotech.com)
Using an unbiased exploratory approach with mass cytometry, followed by targeted flow cytometry, we found that approximately 80% of mature B cells that proliferated in response to acute infection expressed CD11c. (jci.org)
Studies sug- terized by flow cytometry using anti between the immune response and the gest that HCV inhibits receptor genes in CD3, CD56 and CD16 monoclonal virus replication rate [5] and play a cru- the activation of NK cells [20], and the antibodies. (who.int)

Research on vitamin D regulation of thymocyte selection, Th1 and Th17 cells, T-cell programed cell death, and T-regulatory (Treg) cells is summarized and integrated into model mechanisms. (frontiersin.org)
CD4+ Th1 and Th2 memory T-cells are well described, in contrast, Th17, Tfh, Th9, Th22, and Treg lineages have proved more challenging to characterize due to a lack of consistent lineage fidelity. (flowmetric.com)
Thus, understanding how Treg cell identity is controlled, is of utmost importance for the development of novel anti-cancer therapies. (mdpi.com)
Potential roles of rarer subtypes, such as regulatory (Treg) and follicular helper T (Tfh) cells, being associated with tumor biology in other cancer entities, have not been investigated in TGCT. (uni-giessen.de)
This study provides a detailed analysis of TIL focusing on Treg and Tfh in human testicular specimens characterized by hypospermatogenesis and lymphocytic infiltrates (ly) (n=12), pre-invasive germ cell neoplasia in situ (GCNIS -/+ly) (n=15, each), and seminoma (n=28) compared to normal spermatogenesis (n=10). (uni-giessen.de)
Using immunohistochemistry (IHC), T cells were confirmed as most abundant TIL, with Treg and Tfh cells most frequently observed in seminomas. (uni-giessen.de)
Secondary clustering showed that, in addition to CD8+ cytotoxic, proliferating (activated), CCR7+ (newly recruited), and other CD4+ T cells, Treg and Tfh were present with variable frequencies. (uni-giessen.de)

Several monoclonal antibodies (MAbs) with demonstrated clinical anti-cancer activities have been engineered as fully human IgG1 entities to also encompass their potential to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) of human tumor cells. (bmj.com)

Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. (nature.com)

T helper cells recognize antigen presented in the context of major histocompatibility complex II on antigen-presenting cells in a T cell receptor-dependent fashion (not shown). (frontiersin.org)
A. The linear model describes the activation of naïve T-cells by the presentation of antigen-peptide on major histocompatibility complex (MHC) molecules by the antigen presenting cells (APCs) during the contraction phase of a T-cell response. (flowmetric.com)

These cells primarily produce interferon (IFN)-γ and tumor necrosis factor (TNF) that, respectively, activate macrophages and direct cytotoxic CD8 + T cell responses, that in turn promote elimination of intracellular pathogens such as viruses and bacteria ( 8 ). (frontiersin.org)
In vitro, medullary FRCs alone or in combination with macrophages promote PC survival while other LN cell types do not have this property. (ox.ac.uk)
Thus, we propose that this FRC subset, together with medullary macrophages, forms PC survival niches within the LN medulla, and thereby helps in promoting the rapid development of humoral immunity, which is critical in limiting early pathogen spread. (ox.ac.uk)
As an immune-privileged organ, the normal testis immune environment consists of macrophages, mast cells and few T cells, all having anti-inflammatory effects to protect developing germ cells from autoimmune attack. (uni-giessen.de)
In addition, it became clear that the predominance of resident macrophages in normal testes is shifted in favor of T cells as the main component of TIL in TGCT. (uni-giessen.de)
In response to pressure overload such as hypertension, monocytes (a type of white blood cell) enter the heart and become inflammatory macrophages. (kcl.ac.uk)
Therefore, the aim of the present study was to identify a regulatory signaling pathway in cardiac inflammation based on the hypothesis that a distinct subset of inflammation-related activated fibroblasts plays crucial roles in the recruitment of inflammatory cells, especially monocytes/macrophages, and in the pathology of heart failure. (kcl.ac.uk)

Advances in precision oncology continue to facilitate drug development, allowing diseases like lung cancer to be subset into biomarker-defined populations appropriate for targeted therapies," said Julia Beaver, MD, Chief of Medical Oncology in the FDA's Oncology Center of Excellence and acting deputy director of the Office of Oncologic Diseases in the FDA's Center for Drug Evaluation and Research. (hpnonline.com)
The study of each major class of cells has yielded genetic markers that facilitate the identification of these populations. (northwestern.edu)
This technique may be extended to non-neuronal cell types, as well as to rare populations of cells with minor variations. (northwestern.edu)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)

The flow cytometric analysis revealed that these cells consist of mature B cells of a follicular GC origin. (fu-berlin.de)

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. (nature.com)
Although biochemical functions of the human PORCN gene are not well characterized, Wnt signaling may be involved in the phenotypic expression of focal dermal hypoplasia where defective/deficient Wnt signaling could affect cell fate or result in failure of a progenitor cell line to expand. (medscape.com)

Figure 3: High-dimensional analyses of PD-1 hi CXCR5 − and PD-1 hi CXCR5 + cells identify shared and distinct features. (nature.com)
Finally, in situ hybridization analyses revealed the presence of RP11-295G20.2 in the nuclei of corneal epithelial cells, but not in the stromal cells of the human cornea, while RP11-322M19.1 was present in epithelial and non-epithelial cells. (molvis.org)
This work delivers a deeper insight into the mentioned topics by performing the following analyses: i) A kinetic of the GC B cell subsets was conducted by means of flow cytometric analyses and immunofluorescence microscopy methods. (fu-berlin.de)

HDE exposure induced intracellular Ca(2+) mobilization in Beas-2B cells and in primary cell isolates, but this response was neither mimicked by EGF nor inhibited by AG1478. (cdc.gov)

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis. (ox.ac.uk)

CD4 + T cells are key in mediating the host protective and homeostatic responses. (frontiersin.org)
The effects of DCs on adaptive immune responses depend partly on functional specialization of distinct DC subsets, and partly on the activation state of DCs, which is largely dictated by environmental signals. (nih.gov)
CD8+ T-cell mediated immune responses are important in protection against various pathogens and specific tumor antigens associated with various cancers. (flowmetric.com)
Among these, plasticity and existence of subsets are prominent determinants to the quality of the elicited immune responses. (elsevierpure.com)
Collectively, these results identify CD11c as a marker of B cells responding to malaria and further highlight differences in primary and secondary B cell responses during infection. (jci.org)
In order to study the possible role over Ficoll-Hypaque (density 1.077 production, and are the key players in that NK cells might play in the patho- g/L) (Amersham Biosciences) and immune responses to viruses [7]. (who.int)
An aqueous extract of dust from these facilities (hogbarn dust extract [HDE]) induces IL-6 and IL-8 release and several other responses in isolated airway epithelial cells. (cdc.gov)
The cell membrane receptors by which HDE initiates these responses have not been identified. (cdc.gov)
Because several other inhaled agents induce airway epithelial cell responses through epidermal growth factor receptor (EGFR) activation, we hypothesized that HDE would activate EGFRs and that EGFRs would be required for some of the responses to HDE. (cdc.gov)
Exposure of Beas-2B cells to HDE caused EGFR phosphorylation and downstream ERK activation, and both responses were blocked by the EGFR-selective kinase inhibitor AG1478. (cdc.gov)
Thus, HDE activates EGFRs and their downstream signaling, and EGFR activation is required for some but not all airway epithelial cell responses to HDE. (cdc.gov)

Innate lymphoid cells (ILCs) are an important type of innate immune cell, whose role has been highlighted in recent years. (jle.com)
Unlike the distinctive immunogenic pathway for CD8+ T-cell memory, CD4+ T-cell memory is significantly more plastic, involving at least seven distinct cell lineages with diverse effector functions, that play roles in all aspects of adaptive immunity as well as impact many innate immune mechanisms. (flowmetric.com)

In the studies reported here, Avelumab is shown to mediate ADCC of several types of human tumor cell lines (e.g., breast, lung, bladder carcinomas) in vitro, with tumor cell lysis mediated mainly by human CD16+ monocytes and natural killer (NK) cells. (bmj.com)
However, we currently do not know which type of cells in the heart produce CCL and attract monocytes in blood to the heart. (kcl.ac.uk)
A team of researchers, led by Professor Kinya Otsu, showcase how a distinct subset of cardiac fibroblasts become activated by pressure overload and attract monocytes to the heart. (kcl.ac.uk)

A number of micro-evolutionary processes occur within the GCs, leading to the production of high-affinity B cells which acquire the necessary survival signals from T cells and leave the GCs in order to differentiate into plasma cells and memory B cells. (fu-berlin.de)
During development, the blood vascular system arises from endothelial cell progenitors that differentiate from mesodermal cells, mostly through the expression of the transcription factor (TF) ETV2. (nature.com)
Activation of the VEGFA/VEGFR2 signaling and expression of blood vascular endothelial cell (BEC) markers, such as NRP1 and EphrinB2, further differentiate these precursor cells into BECs, which then form the hierarchical network of blood vessels 4 . (nature.com)
However, as with CD8+ T-cells, a small population of the responding cells survive and differentiate into long-lived memory cells. (flowmetric.com)

Supposedly, such a scheme could lead to faster affinity maturation and a higher diversity of GC B cells. (fu-berlin.de)
With a recent push for the improved understanding of neuronal diversity, it is important to identify genes whose expression defines various subpopulations of cells. (northwestern.edu)
The retina serves as an excellent model for the study of central nervous system diversity, as it is composed of multiple major cell types. (northwestern.edu)
Our results provide insights into intestinal stromal cell diversity, location, function, and ontogeny, with implications for intestinal development and homeostasis. (lu.se)

Improved understanding of the underlying cancer biology of this subpopulation of cancer stem cells, thought to drive tumor formation and therapeutic resistance, could potentially lead to improved targeted therapies that prolong patient survival. (cns.org)

Returns a subset of all cells in the dataset based on a boolean expression. (lu.se)

Identification of cell surface markers of distinct BTIC subpopulations will support future study of glioblastoma cancer stem cells, and the potential development of BTIC subpopulation-specific therapeutic strategies. (cns.org)
BACKGROUND: Breast cancer stem cells (BCSCs) have a crucial role in breast carcinogenesis, development, and progression. (harvard.edu)
The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)
To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)

We find that the DDX5 locus is frequently amplified in breast cancer and that breast cancer-derived cells with amplification of DDX5 are much more sensitive to its depletion than breast cancer cells and a breast epithelial cell line that lacks DDX5 amplification. (aacrjournals.org)
Methods: Total RNA was isolated from PNN knockdown human corneal epithelial (HCET) cells or Pnn-deficient mouse corneas, and subjected to real-time-PCR (RT-PCR) assays, and the alternatively spliced lncRNAs were counted. (molvis.org)
Similar EGFR phosphorylation and requirement of EGFRs for maximal IL-6 and IL-8 release were found with primary isolates of human bronchial epithelial cells. (cdc.gov)
[ii] Dye JAAdler KB Effects of cigarette smoke on epithelial cells of the respiratory tract. (who.int)

Our data revealed that resveratrol induced measurable changes in circulating immune cells in humans and showed considerable antioxidant activities and other biological effects in humans in vivo. (hindawi.com)
Here we show that in both mice and humans, NKp46 expression marks a minute population of WT NKT cells with higher activity and potency to become leukemic. (jci.org)
Conclusions These studies provide the rationale for testing expanded natural killer cells in humans. (haematologica.org)
Immunologic Mechanisms: Smoking weakens the function of body defense immune cells and the production of antibodies in humans and animals. (who.int)

These findings demonstrate that resveratrol has some clear biological effects on human circulating immune cells. (hindawi.com)

Lung cancer is the most common cancer type and the leading cause of cancer-related deaths worldwide, with non-small cell lung cancer accounting for 80% to 85% of all lung cancers, according to the American Cancer Society. (hpnonline.com)
mutations tumor genotyping DNA mutational evaluation molecular targeted therapy Launch Recent healing approaches for non-small cell lung cancers (NSCLC) have focused on the development of medicines that disrupt driver mutations to which the lung cancers are addicted. (bioerc-iend.org)

While identification of the antigen(s) that are found predominantly on ILPP B cells and which are recognized by BB6-10A10 is speculative, the antibody appears to react with an immature population of B cells in the follicles of ILPPs and with a subpopulation of sIg low B cells in lymph nodes. (southernbiotech.com)
Concern has been raised that an anti-PD-L1 antibody capable of inducing ADCC may negatively affect PD-L1 expressing immune cell subtypes. (bmj.com)
The production of such "class switched" antibodies is important for optimizing the immune response to particular antigens, since the antibody class defines its effector functions, such as complement activation, opsonization, neutralization of bacterial toxins and mast cell activation. (fu-berlin.de)
Antibody-secreting plasma cells (PCs) arise rapidly during adaptive immunity to control infections. (ox.ac.uk)
Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1. (ox.ac.uk)
The monoclonal antibody UCHL1 identified an antigen present on most thymocytes, a subpopulation of resting T cells within both the CD4 and CD8 subsets, and on mature activated T cells. (ox.ac.uk)

In contrast, the UCHL1- cells do not induce immunoglobulin synthesis and do not proliferate in the presence of soluble antigen, although both the UCHL1- and the UCHL1+ fractions of T cells proliferate well in the presence of PHA. (ox.ac.uk)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)

The generation of the embryonic CNS is a lineage-based process in which neural progenitors, called neuroblasts (NBs), give rise to largely invariant lineages of neural/glial cells. (biologists.com)
Cell lineage analysis techniques have been used to analyse most of the embryonic NB lineages at the histological level. (biologists.com)
The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1 + precursors. (lu.se)
We perform in vivo transplantation and lineage-tracing experiments to demonstrate that adult intestinal fibroblast subsets, smooth muscle cells and pericytes derive from Gli1-expressing precursors present in embryonic day 12.5 intestine. (lu.se)
Trajectory analysis of single cell RNA-seq datasets of E12.5 and adult mesenchymal cells suggest that adult smooth muscle cells and fibroblasts derive from distinct embryonic intermediates and that adult fibroblast subsets develop in a linear trajectory from CD81 + fibroblasts. (lu.se)
We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)

The results agreed with differential gene expression highlighting many TFs that play a critical role in hematopoiesis, endothelial-to-hematopoietic transition, or leukemic stem cell activation. (uni-heidelberg.de)
The propensity of these subsets to harbor latent provirus compared to the more differentiated memory subsets was independent of differential expression of pTEFb components. (unimi.it)

Within the CD4 + and CD8 + T cell subsets, naive cells show pronounced circadian rhythms with a daytime nadir, whereas (terminally differentiated) effector CD8 + T cell counts peak during daytime. (uni-luebeck.de)
The guidelines describe single-platform technology (SPT), a process in which absolute counts of lymphocyte subsets are measured from a single tube by a single instrument. (cdc.gov)
The CD4 cell counts were obtained by using the Becton Dickinson MultiTEST reagent in TrueCOUNT tubes (Becton Dickinson Immunocytometry Systems, San Jose, CA). Comparison of this method with CD4 counts calculated from CBC absolute lymph counts from fresh whole blood X CD4% from the frozen whole blood resulted in a correlation coefficient of 0.9872. (cdc.gov)

This presents a challenge for data analysis and requires rigorous validation methods to ensure that clusters contain cells of the same function. (northwestern.edu)
Single- cell transcriptome sequencing was used, combined with cluster analysis , t-distributed stochastic neighbor embedding (t-SNE) visualization, and other bioinformatics methods to distinguish cell subgroups while using gene ontology (GO) function enrichment and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment to reveal the biological function of each cell subgroup. (bvsalud.org)

Effector CD8 + T cells were positively correlated with epinephrine rhythms, increased after low-dose epinephrine infusion, and showed highest expression of β-adrenergic and fractalkine receptors (CX3CR1). (uni-luebeck.de)
Daytime increases in cortisol via CXCR4 probably act to redistribute naive T cells to bone marrow, whereas daytime increases in catecholamines via β-adrenoceptors and, possibly, a suppression of fractalkine signaling promote mobilization of effector CD8 + T cells from the marginal pool. (uni-luebeck.de)
Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)
A goal of any vaccine should include the stimulation of a robust effector T-cell response, which over time is translated into a large population of memory T-cells. (flowmetric.com)
The most recent research provides evidence that memory T-cells are generated from effector T-cells via epigenetic modifications, as the methylation patterns that are seen in memory cells are similar to those seen in effector cells. (flowmetric.com)
This CD8+ T-cell population is made up of three subsets, naïve, effector, and memory T-cells. (flowmetric.com)
The cells that mediate this response are known as effector memory T-cells (T EM ). (flowmetric.com)
Once the pathogen is cleared, most of these effector cells will undergo apoptosis to maintain the balance of the immune response. (flowmetric.com)
Eradication of the threat during the contraction phase results in the loss through apoptosis of the majority of the adaptive immune effector cells. (flowmetric.com)
This results in the generation of effector T-cells or memory precursors (yellow). (flowmetric.com)
Using a dual-reporter virus that allows discrimination between latent and productive infection at the single-cell level, we found that IL-15-treated primary human CD4+ T naive and CD4+ T stem cell memory (TSCM) cells are less susceptible to HIV infection than CD4+ central memory (TCM), effector memory (TEM), and transitional memory (TTM) cells but are also more likely to harbor transcriptionally silent provirus. (unimi.it)

However, global transcriptomics highlight differences between T PH cells and T follicular helper cells, including altered expression of BCL6 and BLIMP1 and unique expression of chemokine receptors that direct migration to inflamed sites, such as CCR2, CX3CR1, and CCR5, in T PH cells. (nature.com)
In all cases there were no statistical differences pre- vs post-treatment in any immune cell subset, and at any time point analyzed, regardless of whether the immune subset expressed PD-L1 or not. (bmj.com)
The number of cells in clusters 0-3 increased significantly in MCAO group compared to that in the sham group, and nine- cell subpopulations exhibited remarkable differences in the number of genes . (bvsalud.org)

This methodology overcomes many of the hurdles presented by Single-cell RNA-Seq and may be suitable for researchers aiming to profile cell types in a straightforward and highly efficient manner. (northwestern.edu)

Yet, CD4 + T cells are also known to be the main drivers of inflammatory bowel disease (IBD) when this balance is perturbed. (frontiersin.org)
Inflammatory bowel disease is a complex set of diseases that includes Crohn's disease (CD) and ulcerative colitis (UC), each with multiple bacterial, immune, and non-immune cell types contributing to inflammation. (frontiersin.org)
Resveratrol is the most extensively studied stilbene, and preclinical studies have revealed that this compound has several biological effects including, antioxidant, anti-inflammatory, and cytotoxic effects against human cancer cell lines derived from various tumor types [ 1 , 3 , 4 ]. (hindawi.com)
They found that cardiac fibroblasts can produce CCL2 and name the cells inflammatory fibroblasts. (kcl.ac.uk)
Next steps for this research is to identify the marker for the inflammatory fibroblasts to isolate the cell population and examine the characteristics of the cells to regulate their activity. (kcl.ac.uk)
Editorial Comment on: Inflammatory Protein Serum Amyloid A1 Marks a Subset of Conventional Renal Cell Carcinomas with Fatal Outcome. (lu.se)

Naive T cells were negatively correlated with cortisol rhythms, decreased after low-dose cortisol infusion, and showed highest expression of CXCR4, which was up-regulated by cortisol. (uni-luebeck.de)
Microscopy analysis of NF-κB suggested that CD4+ T naive cells express smaller amounts of nuclear NF-κB than the other subsets, partially explaining the inefficient long terminal repeat (LTR)-driven transcription. (unimi.it)
Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)

Each BTIC subtype was characterized by distinct surface markers, and single-cell molecular profiles relating to distinct bulk tissue molecular subtypes. (cns.org)

thus, Pnn may affect crucial alternative splicing (AS) decisions and, in turn, impact cell-type specific gene expression. (molvis.org)
On the other hand, CD4+ TSCM cells display similar levels of nuclear NF-κB to CD4+ TCM, CD4+ TEM, and CD4+ TTM cells, indicating the availability of transcription initiation and elongation factors is not solely responsible for the inefficient HIV gene expression in the CD4+ TSCM subset. (unimi.it)
which means both copies of the gene in each cell have mutations. (medlineplus.gov)
which means one copy of the altered gene in each cell is sufficient to cause the disorder. (medlineplus.gov)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

Conclusions: The data suggest PNN's role in the alternative splicing of a specific subset of lncRNAs might have a significant impact on the corneal epithelium. (molvis.org)
We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)

Yet, our knowledge on the expression of inhibitory molecules on human DC subsets is fragmentary. (nih.gov)
This study has described the complexity of TIL in TGCT and provides first indications that rarer T cell subtypes and their signaling molecules are likely to be of functional importance in the TGCT immune environment. (uni-giessen.de)

Surface markers of distinct BTIC subpopulations were validated in fluorescence-activated cell sorting (FACS) and colony forming assays. (cns.org)
Here, we show that circadian variations in T cell subpopulations in human blood are differentially regulated via release of cortisol and catecholamines. (uni-luebeck.de)

Brain tumor-initiating cells (BTICs), self-renewing multi-potent cells critical for tumor maintenance and growth, are attractive targets of glioblastoma therapy. (cns.org)
In this study, single-cell microfluidic genetic profiling of primary human glioblastoma was performed to characterize intra-tumoral BTIC heterogeneity, identify unique surface markers of BTIC subsets, and associate BTIC subsets with clinically-relevant bulk tissue molecular subtypes. (cns.org)
This is the first demonstration of cancer stem cell heterogeneity in glioblastoma at the single-cell level, and particularly as it relates to prospective isolation and bulk tumor subtypes. (cns.org)

Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? (mdpi.com)
Nevertheless, we find that the transcriptional profile of similar fibroblast subsets differs markedly between the small intestine and colon suggesting region specific functions. (lu.se)

Among malignant neoplasms of the penis, squamous cell carcinoma (SCC) is the most common. (medscape.com)
The cause of penile squamous cell carcinoma (SCC) is unclear, although human papillomavirus (HPV) appears to play a major role in many cases. (medscape.com)

Monoclonal antibodies putatively identifying porcine B cells. (southernbiotech.com)
Development of B cell memory and generation of high affinity antibodies are crucially dependent on germinal centers (GC). (fu-berlin.de)
These memory B cells are able to produce antibodies other than IgM. (fu-berlin.de)

During the immune response activated B cells migrate to the T cell zones within the secondary lymphoid organs and acquire help from the residing antigen-specific, activated T cells. (fu-berlin.de)
These are referred to as CD8+ memory T-cells because they 'remember' this previous encounter with the specific antigen, and they are programmed to elicit a faster and stronger immune response to that same antigen. (flowmetric.com)
The recruitment of the CD4+ subsets during the activation phase is influenced by the type of immunological threat, and they form a coordinated initiative during the expansion phase, to help balance the contribution of each branch of the adaptive immune response to effectively launch an effective, threat-specific response. (flowmetric.com)
Hepatitis C virus (HCV) infection has impaired cellular immune response and circulating NK cells, NK subsets (in- the ability to establish chronic infection virus persistence [8]. (who.int)

Expanded natural killer cells killed both allogeneic and autologous primary myeloma cells avidly via a perforin-mediated mechanism in which the activating receptor NKG2D, natural cytotoxicity receptors, and DNAX-accessory molecule-1 played a central role. (haematologica.org)

DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
They then examined the mRNA expression pattern at a single cell level using so-called single-cell RNA sequencing analysis and found a subset of cardiac fibroblasts highly expressed genes activated by the transcription factor NF-kB and CCL2 mRNA. (kcl.ac.uk)
In response to tissue injury or stress, the resident cardiac fibroblasts undergo a transition to activated myofibroblasts, a highly synthetic cell type that induces the genes encoding smooth muscle α actin (ACTA2) and collagen. (kcl.ac.uk)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

Our results show a novel role for DDX5 in cancer cell proliferation and suggest DDX5 as a therapeutic target in breast cancer treatment. (aacrjournals.org)
Defects in the control of cell proliferation are a hallmark of cancer, and DNA replication is a key process for cell proliferation. (aacrjournals.org)
These data provide evidence that anti-OX40 prior to surgery is safe and can increase activation and proliferation of CD4+ and CD8+ T cells in blood and tumor. (bepress.com)

Anatomy23

Organisms4

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes22

Disciplines and Occupations1

Information Science4

Health Care1

Peripheral12

Dendritic Cells6

Lymphocytes12

Differentiation17

Distinct subsets2

Functionally3

Tissues6

Cytokines4

Pathways5

Microenvironment4

Phenotype4

Tumors10

20181

Myeloid3

Interleukin 152

Abstract2

Patients18

Differentially Expressed1

Flow Cytometry3

Treg7

Tumor cells1

Germinal center1

Antigen-prese2

Macrophages7

Populations4

Cytometric analysis1

Phenotypic2

Analyses3

Intracellular1

Stromal cells1

Responses11

Innate immune2

Monocytes3

Differentiate4

Diversity4

Biology1

Dataset1

Stem cells4

Epithelial4

Humans4

Human circul1

Cancers2

Antibody6

Induce2

Embryonic6

Differential2

Counts3

Methods2

Effector11

Differences3

Single-cell RNA-Seq1

Inflammatory6

Naive3

Relating to distinct1

Gene5

LncRNAs2

Molecules2

Subpopulations2

Glioblastoma3

Transcriptional2

Squamous cell carc2

Antibodies3

Immune response4

Receptors1

Genes4

Proliferation3