Cells of patients patients antigen of tumor. Medical search. Frequent questions

For non-muscle invasive bladder cancer (NMIBC), Bacille Calmette-Guerin (BCG) treatment is the standard immunotherapy for non-high risk NMIBC patients ( 3 ). (frontiersin.org)
Here she explains the use of dendritic cells in cancer immunotherapy. (nature.com)
The cancer immunotherapy field has made tremendous progress, thanks to the development of antibodies against immune-suppressing molecules, such as PD-1 and CTLA-4, that are expressed by cancer cells. (nature.com)
The purpose of T cell-mediated cancer immunotherapy is to reactivate these responses to a degree that results in tumor destruction without causing harmful effects on normal cells. (wikipedia.org)
Nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-associated tumour common in Southern Chinese populations, is a potentially important target for T cell-based immunotherapy. (birmingham.ac.uk)
ICT-107 is a dendritic cell-based immunotherapy targeting multiple tumor-associated antigens. (genengnews.com)
Tumor immunotherapy brings substantial and long-term clinical benefits that can even cure tumors. (hindawi.com)
Tumor immunotherapy refers to novel therapeutic measures that turn the immune system into a destructive force against tumors [ 1 ]. (hindawi.com)
In recent years, tumor immunotherapy has achieved significant success in various cancers and has been one of the hotspots in the life sciences, especially immune checkpoint inhibitors and adoptive cellular therapy [ 3 ]. (hindawi.com)
Our findings show that TRIM28 is necessary for MAGEC2 expression in cancer cells, and TRIM28 may serve as a new potential target for immunotherapy of cancer. (biomedcentral.com)
Moffitt Cancer Center continues to distinguish itself as a world leader in the development of novel immunotherapy treatments, capitalizing on the natural power of the body's immune system to defend itself against the growth and spread of cancerous cells. (moffitt.org)
It is a phase 2b randomized trial of autologous dendritic cell immunotherapy (CMN-001) plus standard treatment for advanced renal cell carcinoma after a nephrectomy ( MCC 21083 ). (moffitt.org)
This CMN-001 is an autologous, tumor antigen-loaded dendritic cell immunotherapy. (moffitt.org)
Chimeric Antigen Receptor (CAR) modified T-cells are an exciting new form of immunotherapy that involves the genetic modification of one's own T-cells to redirect them against proteins on cancer cells. (lls.org)
Chimeric antigen receptor T cells - CAR-T cells, for short - are an innovative development in the field of oncology, contributing to the emergence of immunotherapy as the fourth pillar of cancer treatment , particularly for patients with late-stage or rare forms of cancer. (corning.com)
One challenge in using CAR-T immunotherapy to treat solid tumors is delivering the CAR-T cells directly to the tumor. (corning.com)
IMA101 is a personalized investigational immunotherapy being evaluated for the treatment of multiple cancers, including ovarian, gastric, esophageal, non-small cell lung cancers, and head and neck squamous cell carcinoma. (pharmacytimes.com)
We have optimized the transduction and expansion of murine CAR T cells for cancer immunotherapy (DOI: 10.1084/jem. (unil.ch)
Treatments, including radiation & immunotherapy, have proven to be effective in patients with metastatic solid cancers. (indiatimes.com)
Immunotherapy is emerging as a new form to treat cancer by harnessing the activity of cytotoxic CD8 + T lymphocytes (CTLs) that specifically recognize tumor-associated antigens. (lifeboat.com)
Immunotherapy can fail in patients with cancer when certain cancer cells can hide from the immune system. (lu.se)
However, cDC1 can be compromised in cancer patients and some cancer cells lack these antigen-presenting proteins on their surface, impacting immunotherapy response. (lu.se)
Furthermore, immunotherapy has revolutionized the management of melanoma, specifically, with inhibition of cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), which is expressed on lymphocytes, and programmed death ligand-1, which is expressed on tumor cells. (medscape.com)

Durable Responses and Low Toxicity After Fast Off-Rate CD19 Chimeric Antigen Receptor-T Therapy in Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia. (ucl.ac.uk)
Chimeric antigen receptor T cells for gamma-delta T cell malignancies. (ucl.ac.uk)
Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)
Immunotherapies include checkpoint inhibitory antibodies, chimeric antigen receptor (CAR) T-cells, cancer vaccines, and oncolytic viruses. (moffitt.org)
PHILADELPHIA - Bispecific anti-CD19/CD20 chimeric antigen receptor (CAR) T-cell therapy was well tolerated and showed signs of clinical efficacy in patients with relapsed/refractory B-cell lymphoma, according to phase I clinical trial data presented during Week 1 of the virtual AACR Annual Meeting 2021 , held April 10-15. (aacr.org)
CAR-T cells are made using a patient's T-cells , which are harvested through apheresis and built up in a laboratory through the addition of a chimeric antigen receptor. (corning.com)
Management of Immune-Related Adverse Events in Patients Treated With Chimeric Antigen Receptor T-Cell Therapy: ASCO Guideline. (cdc.gov)

Therapies that target these negative regulator checkpoints, such as those directed against cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed death 1 receptor (PD-1), have demonstrated promising clinical results. (nih.gov)
This occurs because each T cell is endowed with a highly specific receptor that can bind to an antigen present at the surface of another cell. (wikipedia.org)
The T cell receptor binds to a complex formed by a surface protein named "MHC" (major histocompatibility complex) and a small peptide of about 9 amino-acids, which is located in a groove of the MHC molecule. (wikipedia.org)
There a process named central tolerance eliminates the T cells that have a receptor recognizing an antigen present on normal cells of the organism. (wikipedia.org)
ADI-270 has demonstrated a highly differentiated profile stemming from its unique engineering, including targeting via a CAR that incorporates CD27, addition of dominant negative TGF beta receptor armoring, complimentary innate anti-tumor activity of the gamma delta 1 T cells and tissue tropism to solid tumors. (businesswire.com)
ADI-270 is designed to home to solid tumors, with a highly specific targeting moiety for CD70 and an armoring technology of dominant negative TGF beta receptor to address immunosuppressive factors in the tumor microenvironment. (businesswire.com)
These patients had a markedly decreased cytokine production and expressed low levels of T cell receptor CD3ζ chain. (aacrjournals.org)
Trastuzumab is designed to attach to an antigen called human epidermal growth factor receptor 2 (HER2). (who.int)
BT-ON014 trade name] is also used in combination with medicines called aromatase inhibitors with patients with high levels of HER2 and hormone receptor-positive metastatic breast cancer (cancer that is sensitive to the presence of female sex hormones). (who.int)

All sera had high titers of antibodies of the IgM isotype against SGPG (titers over 1:3,200), especially in tumors such as meningiomas, germinomas, orbital tumors, glioblastomas, medulloblastomas, and subependymomas. (karger.com)
No of tumors in the patient is correlated with levels of antibodies signs, symptoms, or routine diagnostic test results were to MCV T antigen ( 12 ), leaving little doubt that MCV is the associated with MCV infection, and no correlation between infectious cause for most but not all MCC tumors. (cdc.gov)
We're seeing promising results of clinical trials with these antibodies, but they still don't work for all patients. (nature.com)
Monoclonal antibodies are used to detect serum antigens associated with specific malignancies. (aafp.org)
Immune checkpoint inhibitors (ICIs) are antibodies that target crucial signaling pathways, such as programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), to improve the activation of T cells and enhance the immune response to cancer cells. (hindawi.com)
Second, these antibodies impair the induction of synaptic plasticity, rebound potentiation, and LTD, on Purkinje cells, resulting in loss of restoration and compensation of the distorted "internal models. (springer.com)
Host Response to Tumors The immune response to foreign antigens consists of Humoral mechanisms (eg, antibodies) Cellular mechanisms (See also Tumor Antigens. (msdmanuals.com)
Antibodies attach themselves to the antigens on the surface of cancerous cells. (wikipedia.org)
Both the TRA-1-60 and TRA-1-81 monoclonal antibodies (MAB4381) recognize antigens that are associated with a pericellular matrix proteoglycan. (sigmaaldrich.com)
Monoclonal antibodies (mAbs) directed against tumor-associated antigens have excellent characteristics to target tumor cells selectively ( 1 - 3 ). (snmjournals.org)
They can also exhibit antibodies to antigens associated with pemphigus vulgaris (desmoglein 3, 130-kd) and pemphigus foliaceus (desmoglein 1, 160-kd), as well as several others, including epiplakin. (medscape.com)
Monoclonal antibodies attach to specific proteins or antigens. (who.int)

On the preclinical front, we are prioritizing the development of ADI-270 as our lead preclinical candidate in renal cell carcinoma and other solid tumor indications. (businesswire.com)
Adicet has reprioritized its preclinical pipeline to focus on the development of ADI-270 as its lead preclinical candidate for renal cell carcinoma, with potential in other solid tumor indications. (businesswire.com)
We look forward to reporting topline data from our Phase 2b ReNeu trial this year, which could support an NDA submission in the first half of 2024, and to advancing our emerging portfolio of BCMA combinations in multiple myeloma and biomarker-defined metastatic solid tumor programs. (biospace.com)
3D multicellular tumor spheroids are a type of 3D cell culture models, which have been shown to more accurately mimic in vivo solid tumor biology. (corning.com)
We aim to elucidate factors in the solid tumor microenvironment that can inhibit CAR T cells and develop decoys/traps or signaling switch receptors to rescue/enhance their activity. (unil.ch)

OX40, GITR, and 4-1BB), can enhance T cell immunity in tumor-bearing hosts. (bepress.com)
Insight into the mechanisms of anti-tumor immunity has generated great enthusiasm for the treatment of patients with advanced melanoma. (nih.gov)
Immunity results from a complex interplay between the adaptive immune system (which is antigen-specific) and the innate immune system (which isn't). (nature.com)
The generation of anticancer immunity depends on DCs presenting cancer antigens to T cells. (nature.com)
Adoptive cellular therapy transmits the sensitized T cells to patients with low cellular immune function, which helps patients obtain antitumor immunity. (hindawi.com)
Due to their proficiency at antigen presentation, DCs are key coordinators in the induction of antitumor immunity. (moffitt.org)
Resident memory CD8 + T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive immunity against pathogens. (lifeboat.com)
However, the specific contribution of Trm cells to anti-tumor immunity is incompletely understood. (lifeboat.com)
8-10 Long-lasting protective immunity relies on the efficient establishment of long-lived memory CD8 + T cells, which have the potential to eradicate primary and disseminated tumors. (lifeboat.com)
On the other hand, human immunity against tumor is mainly performed by the cell immune function in the body. (qigonginstitute.org)
summarize the increasing role of cellular immunity in paraneoplastic pemphigus, evidenced by lesional mononuclear cells and elevated IL-6 levels in sera from paraneoplastic pemphigus patients. (medscape.com)
Alexandra Gabriela Barros Ferreira defends her Ph.D. thesis "Restoring antitumor immunity with dendritic cell reprogramming strategies" on Friday, 17 November, 2023. (lu.se)
My Ph.D. studies have focused on restoring anti-tumor immunity with dendritic cell reprogramming strategies. (lu.se)

Importantly, immune constituents of the tumor microenvironment (TME) can influence therapy response and cancer progression. (mdpi.com)
This study provides fundamental insight into the functional impact of CDK4 inhibition on cells in the tumor microenvironment, which is of high importance and interest to the field. (elifesciences.org)

In addition, we have analyzed serum antibody titers against SGPG, GD3, and OAc-GD3 in patients with neural tumors by ELISA and HPTLC immunostaining. (karger.com)
Serum in a patient with subependymomas also had a high anti-SGGL antibody titer of the IgG and IgA types (titers over 12,800). (karger.com)
reported an inverse selected for hepatitis B surface antigen (HBsAg) positivity correlation between serum anti-BKV IgG optical density and negativity. (cdc.gov)
This finding prompted us to look for semenogelin expression in the serum of lung cancer patients. (astm.org)
A set of 13 serum samples (3 from SCLC and 10 from NSCLC patients) was screened by enzyme-linked immunosorbent assay (ELISA), using a commercially available kit. (astm.org)
One of these antigens, defined by monoclonal antibody TRA-1-60, can be detected in the serum of GCT patients and provides a useful complement to the established serum markers human chorionic gonadotropin and α-fetoprotein, especially in those patients without elevated serum human chorionic gonadotropin or α-fetoprotein. (sigmaaldrich.com)
They will drop off from the cell membrane, as a kind of dissolvable antigen, to be dissolved into the serum, being of sugar protein and mucoglobulin in nature. (qigonginstitute.org)
Serum sCD40Lshowed statistically-significant high levels in HCV-HCC patients compared to HCV-cirrhotic patients and normal controls (P (who.int)
Serum sCD40L had higher diagnostic value in HCC patients compared with serum AFP. (who.int)
Assessment of serum IL-10 levels in HCV patients may provide a possible predictive marker for disease progression. (who.int)
Serum amylase and/or lipase levels are elevated in less than half of patients with resectable pancreatic cancers and are elevated in only one quarter of patients with unresectable tumors. (medscape.com)
Patients with advanced pancreatic cancers and weight loss may also have general laboratory evidence of malnutrition (eg, low serum albumin or cholesterol level). (medscape.com)

ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
Cancer antigen (CA) 27.29 is a monoclonal antibody to a glycoprotein (MUC1) that is present on the apical surface of normal epithelial cells. (aafp.org)
It was the aim of this paper to identify prognostic factors in patients with relapsed or refractory B-cell non-Hodgkin's lymphomas, treated by radioimmunotherapy (RIT) with radioiodinated human/murine chimeric anti-CD20 monoclonal antibody rituximab ( 131 I-rituximab). (karger.com)
Tumors were pretargeted with the bispecific monoclonal antibody (bs-mAb) G250xDTIn-1 and, 72 h later, mice were injected intravenously with one of both radiolabeled peptides. (snmjournals.org)
In this approach a nonradiolabeled bispecific monoclonal antibody (bs-mAb) with antitumor-associated antigen (TAA) and antihapten specificity is injected in the first phase. (snmjournals.org)

Nevertheless, the 5-year survival rate for nonmetastatic MIBC patients (75% of newly diagnosed bladder cancer) is only 36% - 48% after first-line treatment, while the 5-year relative survival is 5% - 36% in metastatic MIBC ( 3 ). (frontiersin.org)
Surgical resection potentially provides the only curative option for patients with limited metastatic disease in liver and/or lung (stage IV disease). (medscape.com)
Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. (nature.com)
Cell therapy with autologous TILs is generally safe and clinically active and may constitute a new treatment strategy in metastatic lung cancer. (nature.com)
Cancer antigen (CA) 27.29 most frequently is used to follow response to therapy in patients with metastatic breast cancer. (aafp.org)
Pembrolizumab (Keytruda), a humanized monoclonal anti-PD-1 antibody, is the first anti-PD-1 antibody approved by the FDA for the treatment of patients with unresectable or metastatic melanoma, non-small-cell lung cancer (NSCLC), head and neck squamous cell carcinoma, cervical cancer, colorectal cancer, and gastric/gastroesophageal junction cancer [ 4 - 10 ]. (hindawi.com)
Peripheral blood mononuclear cells from 123 patients with metastatic renal cell carcinoma, prior to treatment, were found to have a significantly increased arginase activity. (aacrjournals.org)
Metastatic cancer is an advanced type of cancer, caused by uncontrolled cells which further breach the basement membrane of the affected organ and spread to other organs such as the lung, bone, liver or brain through the lymph nodes or the blood vessels. (indiatimes.com)
According to National Cancer Institute , in this deadly disease, cancer cells break away from its primary location (where the cancer originated) and travel through the lymph nodes and blood stream to form new tumours (metastatic tumours) in other parts of the body. (indiatimes.com)
However, there are certain signs and symptoms that can help recognise the disease.The symptoms depend on the size and location of the metastatic tumour. (indiatimes.com)
The treatment for metastatic cancer is often different from the ones used for a normal tumour. (indiatimes.com)
Surgery is generally conducted among patients suffering from spinal cord compression caused by metastatic cancer. (indiatimes.com)
Patients with metastatic epidural spinal cord compression can be treated with direct decompressive surgery alongside post-operative radiotherapy. (indiatimes.com)
You have metastatic breast cancer (breast cancer that has spread beyond the original tumour) with high levels of HER2. (who.int)
Recent data have shown an incidence of brain metastases in ≤ 50% of patients with metastatic melanoma. (medscape.com)

Autologous TILs were expanded ex vivo from minced tumors cultured with interleukin-2. (nature.com)
PCT's competencies in autologous cell therapies, cell manufacturing, cell processing, and delivery make it ideally suited as a manufacturer for ImmunoCellular Therapeutics as we look forward to completing this Phase II trial and seek to secure a strategic partner in connection with a future potential Phase III trial for ICT-107 and its commercialization," states Manish Singh, Ph.D., ImmunoCellular Therapeutics president and CEO. (genengnews.com)
The active components of CMN-001 are autologous, matured dendritic cells, which have been co-electroporated with both in vitro transcribed (IVT) RNA from an autologous tumor specimen and CD40L RNA. (moffitt.org)
The clinical trial is the first to use products consisting of autologous cytotoxic T lymphocytes that target tumor antigens using Immatics' target warehouse, according to a press release. (pharmacytimes.com)
Transfusion of autologous tumor-specific CTLs 1-4 and blockade of T cell inhibitory receptors 5-7 have demonstrated to elicit durable clinical benefit in a significant proportion of patients with melanoma, leukemia, lymphoma and other cancers, who failed to respond to conventional treatments. (lifeboat.com)

Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. (bepress.com)
Here we describe the results from a phase Ib clinical trial (NCT02274155) in which 17 patients with locally advanced head and neck squamous cell carcinoma (HNSCC) received a murine anti-human OX40 agonist antibody (MEDI6469) prior to definitive surgical resection. (bepress.com)
The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) is largely different, and little is known about the anti-tumor mechanism of tumor-infiltrated exhausted CD8 + T cells (Tex) in HNSCC. (elifesciences.org)

Antigenic peptides derived from the encoded proteins are therefore presented on the surface of tumor cells and not on normal cells. (wikipedia.org)
The tumour cells are HLA class I- and II-positive and express a limited subset of EBV latent proteins, namely the nuclear antigen EBNA1 and the latent membrane proteins LMP2 and (in some cases) LMP1. (birmingham.ac.uk)
To ask whether the tumour develops in the presence of a potentially protective host response or in its absence, we set out to determine the prevailing levels of CD4+ and CD8+ T cell memory to these proteins in NPC patients at tumour diagnosis. (birmingham.ac.uk)
70 healthy controls on peptide epitope mini-panels, we found that T cell memory to CD4 epitopes in all three proteins was unimpaired in the blood of patients at diagnosis. (birmingham.ac.uk)
These viral proteins also interact with other several cellular factors and lead to revoke normal cell cycle checkpoint stand cell death mechanisms 13 . (bvsalud.org)

Our work suggests that increases in the tumor-reactive CD103+ CD39+ CD8+ TIL could serve as a potential biomarker of anti-OX40 clinical activity. (bepress.com)
We test T cell responses in a phase I clinical trial of an HPV vaccine in oropharyngeal cancer patients. (cardiff.ac.uk)
We've developed a full clinical trial that we're hoping will start in early 2014, in which we'll try this approach in a larger number of patients with the same diagnosis. (nature.com)
So far, however, we have seen a discrepancy between the immunogenicity of DC vaccines and their clinical efficacy - for example, some patients who get an immune boost in response to the vaccine nevertheless show no tumour regression. (nature.com)
Fig. 2: Clinical activity of TILs and patient survival. (nature.com)
PCT served as primary manufacturer for Dendreon during seven years of clinical trials for its prostate cancer cell-based treatment, Provenge. (genengnews.com)
However, a consistent increase in tumor marker levels, coupled with lack of clinical improvement, may indicate treatment failure. (aafp.org)
Our lab is currently working on understanding the extreme responders and extreme clinical phenotypes of brain and spinal cord tumors to identify factors that may modulate responses to therapy. (hopkinsmedicine.org)
Dr. Brem and his colleagues have designed and led many multi-institutional clinical trials to improve and expand the range of therapeutic options for patients with brain tumors . (hopkinsmedicine.org)
REDWOOD CITY, Calif. & BOSTON--( BUSINESS WIRE )--Adicet Bio, Inc. (Nasdaq: ACET), a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer, today reported financial results and operational highlights for the third quarter ended September 30, 2023. (businesswire.com)
Clinical and translational medicine data for our lead asset ADI-001 in NHL has provided us with valuable insights, which has guided us as we initiated the EXPAND cohort in post CAR T LBCL and continue to enroll MCL patients to the clinical study. (businesswire.com)
Adicet continues to expect that it will provide a clinical update from the Phase 1 study in NHL patients in the second half of 2024. (businesswire.com)
STAMFORD, Conn., Feb. 28, 2023 (GLOBE NEWSWIRE) -- SpringWorks Therapeutics, Inc. (Nasdaq: SWTX), a clinical-stage biopharmaceutical company focused on developing life-changing medicines for patients with severe rare diseases and cancer, today reported financial results for the fourth quarter and full-year periods ended December 31, 2022 and provided an update on recent company developments. (biospace.com)
The incidence rate for any grade ICIs-related neurologic ir-AEs in patients included in clinical trials has been reported to be approximately 3.8% to 12% [ 20 ]. (hindawi.com)
Notably, in the JCAR015 Phase 2 Clinical Trial (ROCKET) conducted by Juno Therapeutics, five patients died because of severe cerebral edema, causing the cessation of clinical trials by the FDA [ 22 ]. (hindawi.com)
The Breast Oncology Department , for example, has developed innovative clinical trials for vaccines that offer new ways to treat various types and stages of breast cancer and improve patient outcomes. (moffitt.org)
We will analyze patient apheresis, final CAR-T product, and peripheral blood samples from subjects enrolled on an ongoing clinical trial (NCT04186520). (lls.org)
Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
A high-throughput system, like the one utilized in the Corning study, could provide additional insight into antigen targets before the clinical stage. (corning.com)
Tissue Expression of Melanoma-associated Antigen A6 and Clinical Characteristics of Gastric Cancer. (nih.gov)
Immatics recently announced patient enrollment into a phase 1 clinical trial of its adoptive cellular therapy (ACT) IMA101, which uses its ACTolog approach. (pharmacytimes.com)
Entering clinical development with our first adoptive cell therapy program is a significant step for Immatics, and highlights the ability of the XPRESIDENT platform to identify novel and true tumor antigens directly from a patient's tumor," said Harpreet Singh, PhD, chief scientific officer and CEO at Immatics US. (pharmacytimes.com)
Its clinical-stage cell therapy candidates include SQZ Enhanced APC (eAPC. (stockhouse.com)
The vaccine has already passed Phase I and II clinical trials with promising results: previous studies have shown that BiovaxID significantly increases both the time interval between relapses (44.2 months, as compared with 30.6 months in a placebo group) as well as patients' overall survival rates. (singularityhub.com)
Last month at the Active Immunotherapeutics Forum, Accentia's chief science officer Dr. Carlos Santos reported positive findings in Phase II clinical trials to treat mantle cell lymphoma . (singularityhub.com)
Vaccination strategies eliciting CTL responses specific for tumor-specific and self-antigens have shown promising results in recent clinical trials. (lifeboat.com)
3, 4 Several tumour vaccines directed against MUC1 core protein, oligosaccharides, or MUC1 cDNAs have been shown to stimulate immune reactions in basic clinical trials to confer antitumour activity. (bmj.com)
Factors to consider when assessing the level of immune competence in a patient include underlying disease severity, duration, clinical stability, complications, comorbidities, and any potentially immune-suppressing treatment. (cdc.gov)
ABSTRACT The study's objective was to evaluate the clinical significance of sCD40L in HCV- associated hepatocellular carcinoma (HCV-HCC) patients. (who.int)
The most difficult clinical situation in which to diagnose pancreatic carcinoma is in the patient with underlying chronic pancreatitis. (medscape.com)
2014) 16 reported and compared the histologic, immunohistochemical and clinical features as well as the survival rates of carcinoma arising in patients with PVL (p-scca) and conventional squamous cell carcinoma (c-scca). (bvsalud.org)

In adults, MCV is typically an asymptomatic, common, and occurs largely in childhood, with BKV seroprevalence commensal viral infection that initiates rare cancers after virus (rather than host cell) mutations. (cdc.gov)
But cancers can create an environment that inhibits T cells. (nature.com)
The tumour antigens can either be shared antigens, which are expressed by many cancers, or patient-specific antigens. (nature.com)
Both tumors are difficult to treat, and new therapies are urgently needed for these cancers. (hopkinsmedicine.org)
For patients with these advanced cancers, the prognosis remains poor and patients are in need of new, more effective and better tolerated therapies," said Chen Schor, President and Chief Executive Officer at Adicet Bio. (businesswire.com)
This therapy is most advanced in blood cancers, specifically B-cell lymphomas and leukemias, with multiple FDA approved CAR T-cells treatments targeting the CD19 protein now available. (lls.org)
Nature Medicine Oct 2020) documented a high overall response rate in patients with relapsed B-cell cancers. (lls.org)
Immatics expects to enroll up to 20 patients with relapsed and/or refractory solid cancers that have no current treatment options, according to the release. (pharmacytimes.com)
Immunopeptidomics typically requires a minimum of 50-100 million cells, exceeding what can typically be obtained from blood cancers. (bmj.com)
Memory CD8 + T cell responses have the potential to mediate long-lasting protection against cancers. (lifeboat.com)
Emerging evidence indicates that Trm cells develop in human solid cancers and play a key role in controlling tumor growth. (lifeboat.com)
The detection of HHV-1 antigen, chemicals and radiation, found to play important role in the development of oral cancers in Iraq. (bvsalud.org)

Another interest of the group is the definition of immune signatures based on immune cell phenotype and function, as prognostic markers. (cardiff.ac.uk)
Each clinicopathologic subtype can be further classified with respect to morphology, immunophenotype, and antigen markers. (medscape.com)
These tumor markers are most useful for monitoring response to therapy and detecting early relapse. (aafp.org)
With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
Because family physicians are assuming a greater role in caring for patients with cancer, an understanding of tumor markers is becoming increasingly important. (aafp.org)
This article describes the use of common tumor markers in primary care practice. (aafp.org)
Nevertheless, tumor markers can play a crucial role in detecting disease and assessing response to therapy in selected groups of patients. (aafp.org)
Stimulation of BM CD20(+) B cells by CpG-containing oligodeoxynucleotide-enhanced expression of activation markers (CD86 and CD54) triggered IL-6 and TNF-alpha secretion and cell proliferation. (nih.gov)
Cell separation studies showed that the increased arginase activity was limited to a specific subset of CD11b+, CD14−, CD15+ cells with a polymorphonuclear granulocyte morphology and markers, instead of macrophages or dendritic cells described in mouse models. (aacrjournals.org)
These subtypes also exhibit cell surface markers that can be exploited by the vaccine. (singularityhub.com)
Background: Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. (researchgate.net)
Methods: Identification of tumour-associated endothelial markers (TEM) by comparing antigen expression on normal vs t-CEC and assess the presence of t-CEC in peripheral blood of cancer patients by incorporating TEM in our novel flow cytometry-based CEC detection assay. (researchgate.net)
Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. (researchgate.net)
Even tumor markers can be elevated in patients with chronic pancreatitis. (medscape.com)

Related studies have reported that the complete response rate of CD19-CAR-T cells in hematological malignancies is approximately 88-90% [ 13 , 14 ]. (hindawi.com)
To address that mechanism of relapse, we initiated a first-in-human trial of dual targeted anti-CD20, anti-CD19 CAR (CAR20.19) T-cells for B-cell malignancies. (lls.org)
The presented analysis included five patients with B-cell malignancies that were positive for both CD19 and CD20 tumor antigen expression. (aacr.org)
For patients with B-cell malignancies, CAR-T therapy has shown the possibility of achieving complete remission. (corning.com)
Therefore, our work highlights the therapeutic potential of vaccination-induced Trm cells to achieve potent protection against skin malignancies. (lifeboat.com)
PDF) Kraan J, van den Broek P, Verhoef C, Grunhagen DJ, Taal W, Gratama JW, Sleijfer SEndothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells. (researchgate.net)
Of all patients with malignancies, 58% had CD276+ CEC counts above the ULN (8 cell per 4 ml). (researchgate.net)

The SQZ AAC platform is designed to induce antigen presentation in vivo by deriving antigen carriers from engineering red blood cells (RBCs) with tumor specific antigens and adjuvants. (stockhouse.com)
We focused particularly on harnessing reprogramming, or direct cellular reprogramming, to induce antigen presentation in cancer cells. (lu.se)
Direct reprogramming strategies with cDC1-specific factors can induce antigen-presentation in cancer cells, making cancer cells visible to the immune system and easier to fight. (lu.se)

Healthy humans develop spontaneous CD8+ T cell responses to melanoma associated antigens (MA) expressed by normal melanocytes. (mdpi.com)

Comparison of tumor biopsies before and after treatment reveals an increase of activated, conventional CD4+ tumor-infiltrating lymphocytes (TIL) in most patients and higher clonality by TCRβ sequencing. (bepress.com)
T lymphocytes are cells of the immune system that attack and destroy virus-infected cells, tumor cells and cells from transplanted organs. (wikipedia.org)
In other instances, the normal peptide is presented at the cell surface and consequently the T lymphocytes that recognize the antigen have been eliminated by the central tolerance process that occurs in the thymus. (wikipedia.org)
Accumulating data indicate that BM of RA patients participates in the pathogenesis of this disease as a site of proinflammatory cytokines overproduction and lymphocytes activation. (nih.gov)

In addition, the advent of immunotherapies, specifically, agents that target cytotoxic T-lymphocyte antigen-4, anti-programmed death-1, and programmed death ligand-1, has increased the potential therapeutic options available to patients with both systemic and brain disease. (medscape.com)

Carcinoembryonic antigen is used to detect relapse of colorectal cancer, and CA 19-9 may be helpful in establishing the nature of pancreatic masses. (aafp.org)
Immune checkpoint inhibition is an effective anti-cancer therapeutic approach but has shown limited efficacy in treating colorectal cancer (CRC) patients. (mdpi.com)
Circulating Tumour DNA and Colorectal Cancer: the Next Revolutionary Biomarker? (cdc.gov)

Combined AFP and β-hCG testing is an essential adjunct in the evaluation and treatment of nonseminomatous germ cell tumors, and in monitoring the response to therapy. (aafp.org)
Human embryonal carcinoma (EC) cells are the stem cells of teratocarcinomas, and they are key components of germ cell tumors (GCTs). (sigmaaldrich.com)

To characterize biomarkers in neural tumors, we analyzed the acidic lipid fractions of 13 neural tumor cell lines using enzyme-linked immunoabsorbent assay (ELISA) and high-performance thin-layer chromatography (HPTLC) immunostaining. (karger.com)
Our data indicate that certain GSL antigens, especially SGGLs, GD3, and OAc-GD3, are expressed in neural tumor cells and may be considered as tumor-associated antigens that represent important biomarkers for neural tumors. (karger.com)
Unfortunately, not all patients respond to these therapies, and evaluation of biomarkers predictive of response is ongoing. (nih.gov)
Secondary objectives include, feasibility, persistence of T-cells in vivo , and assessment of anti-cancer activity, and biomarkers. (pharmacytimes.com)

The group has a long-standing interest in T cell responses against oncogenic human papillomaviruses (1-6). (cardiff.ac.uk)
We developed techniques to detect weak T cell responses against HPV, define CD8 and CD4 epitopes and to isolate T cell clones capable of killing cervical cancer cells. (cardiff.ac.uk)
Particularly, negative regulators of the immune system, called immunologic checkpoints, have been found to play important roles in restraining otherwise effective anti-tumor immunologic responses. (nih.gov)
Dendritic cells (DCs) provide an essential link between the innate and adaptive immune responses. (nature.com)
It is now proven that tumor-specific antigens exist and that patients mount spontaneous T cell responses against such antigens. (wikipedia.org)
In cancer patients, about one half of the highly tumor-specific antigens recognized by spontaneous T cell responses are encoded by mutated genes, the other half being encoded by cancer-germline genes. (wikipedia.org)
In most cases NPC patients also showed detectable responses to CD8 epitopes relevant to their HLA type, the one consistent exception being the absence in patients of a B*4001-restricted response to LMP2. (birmingham.ac.uk)
Two patients achieved complete responses that were ongoing 1.5 years later. (nature.com)
Fig. 3: Examples of complete responses mediated by TIL-recognizing tumor antigens. (nature.com)
Clonal expansion of T memory stem cells determines early anti-leukemic responses and long-term CAR T cell persistence in patients. (ucl.ac.uk)
Most humoral responses cannot prevent tumor growth. (msdmanuals.com)
Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. (msdmanuals.com)
Moreover, clinically applicable vaccination strategies that efficiently establish Trm cell responses remain largely unexplored and are expected to strongly protect against tumors. (lifeboat.com)
Here we demonstrated that a single intradermal administration of gene- or protein-based vaccines efficiently induces specific Trm cell responses against models of tumor-specific and self-antigens, which accumulated in vaccinated and distant non-vaccinated skin. (lifeboat.com)
Interestingly, vaccination-induced Trm cell responses strongly suppressed the growth of B16F10 melanoma, independently of circulating memory CD8 + T cells, and were able to infiltrate tumors. (lifeboat.com)
However, responses vary significantly among eligible patients. (lu.se)

To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oral squamous cell carcinoma (OSCC) and the difference in its expression level between positive and negative HPV-16 (human papilloma virus- 16) OSCC patients. (bvsalud.org)
The recurrence is a serious prognostic influence in patients with oral squamous cell carcinoma (OSCC) 1-3 . (bvsalud.org)

the therapeutic goal must therefore be to re-direct the existing memory repertoire more effectively against antigen-expressing tumour cells. (birmingham.ac.uk)
Twenty-four patients were enrolled prospectively and were treated with unlabeled rituximab 70 mg and a therapeutic activity (median 7.3 GBq) of 131 I-rituximab. (karger.com)
Besides high affinity and long tumor retention, the DOTA-conjugated ligand PSMA-617 has low kidney uptake, making it an excellent choice for therapeutic application. (snmjournals.org)
However, several antigens with selective expression on the surface of tumor cells are not associated with the major histocompatibility complex and may be candidates for therapeutic targeting. (msdmanuals.com)
[6] Their targeting ability was believed to limit side effects for cancer patients and give a wider therapeutic window than other chemotherapeutic agents, although this promise hasn't yet been realized in the clinic. (wikipedia.org)
Therapeutic efficacy of these radionuclides depends on the E max , physical half-life, and residence time of the radiolabel in the tumor. (snmjournals.org)
Accordingly, the radiation dose to the tumor, correlating with the therapeutic efficacy of pretargeted RCC, can be enhanced substantially. (snmjournals.org)
So far, radioimmunotherapy (RIT) has only induced significant therapeutic effect in patients with hematologic tumors, presumably due to their relatively high radiosensitivity ( 4 , 5 ). (snmjournals.org)
[ 5 ] In this review, we discuss advances in the management approach to brain metastases in patients with melanoma and we highlight the current and potential therapeutic options for the management of this devastating disease. (medscape.com)

It was a cell-based therapy. (nature.com)
Adjuvant (postoperative) therapy is used in selected patients with stage II colon cancer who are at high risk of recurrence, and is standard for stage III colon cancer. (medscape.com)
Biologic agents have assumed a major role, typically as targeted therapy based on genetic analysis of the tumor. (medscape.com)
ImmunoCellular Therapeutics has decided to use Progenitor Cell Therapy (PCT) to produce its Phase II glioblastoma vaccine, ICT-107. (genengnews.com)
Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
The laboratory has advanced the understanding of gene therapy, angiogenesis, intracranial implantation of biodegradable polymers to treat malignant glioma, tumor genetics and proteomics, microchip drug delivery and drug resistance studies. (hopkinsmedicine.org)
With a focused organization and clear priority for advancing a pipeline with the highest probability of success, we believe we are well positioned for long-term success as leaders in the allogeneic T cell therapy field. (businesswire.com)
The Company is advancing the development of ADI-001, the Company's investigational therapy targeting CD20 for the potential treatment of relapsed or refractory B-cell non-Hodgkin's lymphoma (NHL). (businesswire.com)
The distribution of grade 3-4 neurologic ir-AEs frequency was 0.7% among patients receiving anti-CTLA-4 (ipilimumab and tremelimumab), 0.4% among patients receiving anti-PD1 (nivolumab, pembrolizumab, lambrolizumab, and pidilizumab), and 0.7% among patients receiving a combination therapy (anti-CTLA-4 + anti-PD1) [ 20 ]. (hindawi.com)
The latest addition to oncotherapy is the use of dendritic cell (DC) vaccine therapy. (moffitt.org)
A dendritic cell vaccine is a cross between a vaccine and a cell therapy. (moffitt.org)
CMN-001 is indicated for the treatment of intermediate/poor-risk patients with advanced renal cell carcinoma (RCC) in combination with nivolumab plus ipilimumab as first-line therapy and in combination with lenvatinib plus everolimus as 2nd line therapy post-first-line failure. (moffitt.org)
For those with relapsed aggressive B-cell lymphoma, anti-CD19 CAR T-cell therapy can achieve a long-term remission in 30-40% of patients. (lls.org)
One proposed mechanism to explain the failure of single targeted CD19 CAR T-cell therapy is that tumors escape CAR T-cells by ridding itself of the CD19 protein. (lls.org)
Findings from this study would not only be applicable to those receiving CAR20.19 T-cells but have potential to enhance outcomes for any patient receiving cell therapy. (lls.org)
Anti-CD19 CAR T-cell therapy has revolutionized the management of this disease in recent years, but it still has several limitations," she noted, explaining that approximately half of patients relapse within six months of starting the treatment due to a lack of CAR T-cell persistence and/or downregulation of the target antigen, CD19, on the tumor. (aacr.org)
The prognosis of patients who relapse after CAR T-cell therapy is dismal," Ghafouri added. (aacr.org)
This is the first bispecific CAR T-cell therapy developed with naïve memory T cells to be tested in patients," she said. (aacr.org)
Patients had received a median of four prior lines of therapy, and four patients had received bridging therapy. (aacr.org)
Our findings raise the possibility of a lasting long-term remission with bispecific CAR T-cell therapy in patients with this aggressive disease. (aacr.org)
Ghafouri and colleagues plan to expand their patient cohort and are also interested in evaluating the therapy in additional B-cell lymphoma subtypes. (aacr.org)
Testing CAR-T therapy on 3D spheroids can help scientists pick the proper antigen targets. (corning.com)
Prostate-specific membrane antigen (PSMA) is an excellent target for radionuclide therapy of metastasized castration-resistant prostate cancer (mCRPC). (snmjournals.org)
We retrospectively report our experience with 177 Lu-PSMA-617-targeted radionuclide therapy in a case series of mCRPC patients resistant to other treatments. (snmjournals.org)
The ACTolog technique also creates multiple cell therapy products to target each antigen, which may be more effective than targeting a single antigen, Immatics reported. (pharmacytimes.com)
The selection and creation of the ACTolog cell therapy drug is tailored for each patient, making the treatment precise. (pharmacytimes.com)
The primary objective of the new study is to assess the safety and tolerability of the ACTolog therapy in patients with target-positive solid tumors, according to the release. (pharmacytimes.com)
In oncology, it is developing cell therapy platforms that are based on directing tumor antigen-specific immune activation via engineered antigen presentation. (stockhouse.com)
Patients were therefore divided into two groups to observe the changing status before and after the qigong therapy. (qigonginstitute.org)
1. 46 cases of different cancer patients were selected for studying the content variations of specific types of protein in the body before and after the qigong therapy. (qigonginstitute.org)
2. 58 cases of different cancer patients were selected for studying the cell immune function in the body before and after the qigong therapy. (qigonginstitute.org)
And the result of the changes of the immune functions of cells in Group 2 indicates that the qigong therapy not only reinforced the T-cell function, but also performed a two-way immune regulation according to the different steps of immune disorder. (qigonginstitute.org)
This explains that the qigong therapy performs a two-way immune regulation according to the different steps of immune disorder, in addition to regulation of the contents of specific protein in the body and controlling the abrupt changes of cells. (qigonginstitute.org)
All HIV-infected patients undergoing treatment for TB should be evaluated for antiretroviral therapy, because most patients with HIV-related TB are candidates for concurrent administration of antituberculosis and antiretroviral drug therapies. (cdc.gov)
Ideally, the management of TB among HIV-infected patients taking antiretroviral drugs requires a) directly observed therapy, b) availability of experienced and coordinated TB/HIV care givers, and in most situations, c) use of a TB treatment regimen that includes rifabutin instead of rifampin. (cdc.gov)
Because alternatives to the use of rifampin for antituberculosis treatment are now available, the previously recommended practice of stopping protease inhibitor therapy to allow the use of rifampin for TB treatment is no longer recommended for patients with HIV-related TB. (cdc.gov)
Physicians and patients also should be aware that paradoxical reactions might occur during the course of TB treatment when antiretroviral therapy restores immune function. (cdc.gov)
Adding to CDC's current recommendations for administering isoniazid preventive therapy to HIV-infected persons with positive tuberculin skin tests and to HIV-infected persons who were exposed to patients with infectious TB, this report also describes in detail the use of new short-course (i.e., 2 months) multidrug regimens (e.g., a rifamycin, such as rifampin or rifabutin, combined with pyrazinamide) to prevent TB in persons with HIV infection. (cdc.gov)
Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update. (cdc.gov)
For patients with more than a single brain metastasis, radiation therapy, including stereotactic radiosurgery and whole-brain radiation therapy, has been the mainstay of treatment. (medscape.com)

B cells and T cells of the adaptive immune system use receptors that recognize antigens, or their derived peptides, in a highly specific manner. (nature.com)
Whereas each T cell recognizes a single antigen, collectively the T cells are endowed with a large diversity of receptors targeted at a wide variety of antigens. (wikipedia.org)

Some genes are expressed by tumor cells and not by normal cells. (wikipedia.org)
A class of genes, named cancer-germline genes, is expressed in a large variety of cancer cells but not in normal cells, with the exception of germline cells, which do not carry MHC molecules on their surface and therefore do not present the antigens. (wikipedia.org)
The transformed cells often express permanently some viral genes. (wikipedia.org)
Mutated genes contribute greatly to the immunogenicity of human tumors. (wikipedia.org)
Cancer-germline genes are an important source of tumor-specific antigens. (wikipedia.org)
These genes are expressed in a significant fraction of tumors of many different histological types. (wikipedia.org)
This clonal expansion and subsequent growth of the tumors appears to be caused by mutations in oncogenes and tumor suppressor genes, and the whole process is accelerated by defects in genes required for maintaining genetic instability. (hopkinsmedicine.org)
Mutations in four or five such genes are required for a malignant tumor to form, while fewer mutations suffice for benign tumorigenesis. (hopkinsmedicine.org)
Current studies are aimed at the further characterization of the mechanisms through which these genes act, the identification of other genes that play a role in this tumor type, and the application of this knowledge to patient management. (hopkinsmedicine.org)
During the embryonic period, the genes in the chromosomes of cells are very active, producing many types of antigens. (qigonginstitute.org)
Interestingly, P-Tex cells expressed CDK4 genes as high as cancer cells, which could be simultaneously inhibited by CDK4 inhibitors and might be a potential reason for the ineffectiveness of CDK4 inhibitors in treating HPV-positive HNSCC. (elifesciences.org)

PCT's cGMP plant in Mountain View, CA, will serve as a second manufacturing site for this dendritic cell-based vaccine. (genengnews.com)
Now researchers at Moffitt are working to develop a dendritic cell vaccine targeting HER3, a protein involved in the growth and spread of many different cancer types. (moffitt.org)
Dendritic cell vaccines can potentially be used to treat different cancer types. (moffitt.org)

TCR sequencing and cloning methods for repertoire analysis and isolation of tumor-reactive TCRs. (unil.ch)
Methods: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up. (researchgate.net)

In contrast, fucosyl-GM1 was not found to restrict to small cell lung carcinoma cells. (karger.com)
At present, only a few areas of mRNA vaccine research have made progress, such as prostate cancer, non-small cell lung cancer, melanoma and so on ( 8 - 10 ). (frontiersin.org)
The contribution of these antigens to tumor immunogenicity is expected to vary according to the mutation rate: higher in lung carcinomas arising in tobacco smokers, in melanomas owing to mutations induced by UV and in the 15% of colorectal carcinomas that have hypermutated DNA owing to defects in the DNA mismatch repair pathway. (wikipedia.org)
We conducted a single-arm open-label phase 1 trial ( NCT03215810 ) of TILs administered with nivolumab in 20 patients with advanced non-small cell lung cancer following initial progression on nivolumab monotherapy. (nature.com)
Addeo, A., Banna, G. L., Metro, G. & Di Maio, M. Chemotherapy in combination with immune checkpoint inhibitors for the first-line treatment of patients with advanced non-small cell lung cancer: a systematic review and literature-based meta-analysis. (nature.com)
Myeloid suppressor cells with high arginase activity are found in tumors and spleen of mice with colon and lung cancer. (aacrjournals.org)
Recently, it has been demonstrated that semenogelins are also ectopically expressed in small cell lung carcinomas (SCLC) and in a minority of non-small cell lung carcinomas (NSCLC). (astm.org)
they're also working on ways to administer the cells locally, such as into the intrapleural space for lung cancer. (corning.com)
Knockdown of MAGE-A6 enhanced the irradiation sensitivity of non-small cell lung cancer cells by activating the AMPK pathway. (nih.gov)
One can know the lung is affected when the patient experiences shortness of breath. (indiatimes.com)
This article presents a study on the unique effect of qigong in helping patients survive some difficult diseases, especially a study over the anti-tumor mechanism of qigong on the basis of a selection of 104 cases of different cancer patients, e.g. esophagus cancer, stomach cancer, rectum cancer, lung cancer, adenocarcinoma of breast, etc. (qigonginstitute.org)
However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are limited. (bvsalud.org)
We retrospectively compared the number of NSCLC tumor cells in peripheral lung lesions obtained using an ultrathin bronchoscope and a thin bronchoscope with radial EBUS between April 2020 and October 2021. (bvsalud.org)
We hypothesized that, in CBD, failure of IL-10 to modulate the beryllium-specific, cell-mediated immune response would result in persistent, maximal cytokine production and T lymphocyte proliferation, thus contributing to the development of granulomatous lung disease. (cdc.gov)

That's why, in patients from whom we can get tumour samples, we're going to try to identify patient-specific mutations and go after these in the boosting phase of the trial. (nature.com)
As cancer progresses, the genome of cancer cells accumulates point mutations and other genetic abnormalities. (wikipedia.org)
Genetic processes other than point mutations can lead to tumor-specific antigens. (wikipedia.org)
In exploratory analyses, we found T cells recognizing multiple types of cancer mutations were detected after TIL treatment and were enriched in responding patients. (nature.com)
As the mutations accumulate, the tumors become progressively more dangerous. (hopkinsmedicine.org)
Epilepsy and related challenges in children with COL4A1 and COL4A2 mutations: A Gould syndrome patient registry. (cdc.gov)
Creating Breast and Gynecologic Cancer Guidelines for Transgender Patients With BRCA Mutations. (cdc.gov)

But though T cells can cross the blood-brain barrier and reach brain tumors, for example, they don't usually arrive in sufficient numbers to kill the tumor. (corning.com)
Molecular profile to guide personalized medicine in adult patients with primary brain tumors: results from the ProfiLER trial. (cdc.gov)

Details of Adicet's lead optimization process and differentiated prostate specific membrane antigen (PSMA) binding moiety were presented at the conference. (businesswire.com)
Prostate-specific membrane antigen (PSMA) is a promising target for directing new therapies. (snmjournals.org)

The timely and accurate identification of neurotoxicity helps clinicians detect and treat these complications early, thereby enhancing treatment efficiency and improving the prognosis of patients. (hindawi.com)
Together, our findings suggest a promising role for P-Tex cells in the prognosis of patients with HPV-positive HNSCC by providing modest but persistent anti-tumor effects. (elifesciences.org)

This leads to the presentation of viral antigenic peptides absent from normal cells. (wikipedia.org)
Dendritic cells can be used as a vaccine by preparing together with either peptides or small portions of tumor antigens and they can then be injected into the body. (moffitt.org)
Conclusions Highly sensitive, low input immunopeptidome analysis enables the discovery of HLA peptides presented by primary MM tumor cells. (bmj.com)
The uptake and retention in the tumor of 111 In-/ 125 I-labeled bivalent peptides ( l -a.a. peptide and d -a.a. peptide) were studied in female BALB/c athymic mice with subcutaneous SK-RC-52 RCC tumors. (snmjournals.org)
The biodistribution of the radioiodinated d -a.a. peptide was highly similar to that of the 111 In-labeled d -a.a. peptide, and both radiolabeled peptides were retained significantly better in the tumor than the 111 In-labeled l -a.a. peptide. (snmjournals.org)
Uptake and retention in the tumor of the iodinated peptide after pretargeting with a bs-mAb can be significantly improved using d -a.a. peptides. (snmjournals.org)

When the CAR-T cells return to the patient's body, they target cell-surface antigens expressed on tumor cells. (corning.com)
This procedure will help retain and regain the patient's ability to walk longer as compared to patients treated with radiotherapy alone. (indiatimes.com)

3. The anti-tumor mechanism of the human body is mainly performed by the immune function of the cells. (qigonginstitute.org)

The alterations we find are then studied in-depth to determine how they contribute to the development of cancer, whether it is promoting tumor growth, enhancing the ability for the cancer to invade into normal tissue, or preventing the various fail-safe mechanisms programmed into our cells. (hopkinsmedicine.org)

Solid cancerous masses are often hypoxic, acidic, and immunosuppressive, The Scientist writes, and T cells have a hard time surviving in that environment - if they can infiltrate it at all. (corning.com)
Next, they link up the cancerous cell with a protein molecule which makes it easier for the immune system to recognize the tumor-specific marker as foreign or undesirable. (singularityhub.com)
Once there is a cancerous change in the cell, however, they become active again. (qigonginstitute.org)

Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells. (ucl.ac.uk)
Patients with PSMA-positive tumor phenotypes were selected by molecular imaging. (snmjournals.org)
Accentia takes cancer cell samples from an individual's body and identifies a tumor-specific molecular marker (an antigen) along the cell surface. (singularityhub.com)
They express several high molecular weight glycoprotein antigens that are down-regulated upon differentiation. (sigmaaldrich.com)
By immunoprecipitation, target antigens were identified from skin extracts with molecular weights of 250, 230, 210, and 190 kd. (medscape.com)

The laboratory focuses on developing new therapies for brain and skull base tumors , and has established the first primary skull base chordoma xenograft mouse model. (hopkinsmedicine.org)
Emerging data suggest that the combination of DC-based vaccination with other cancer therapies may fully unleash the potential of DC-based cancer vaccines and improve patient survival. (moffitt.org)
Data from these studies will advance CAR T-cell therapies for lymphoma patients. (lls.org)
The Company is focused on unlocking the full potential of cell therapies to benefit patients. (stockhouse.com)
With these advances, early trials have demonstrated improved overall survival in patients with brain metastases who receive these therapies either as single agents or as part of multimodality treatment regimens. (medscape.com)

After each injection, we saw an expansion of T cells specific to the vaccine antigens in his blood, so it was clear that the DC treatment boosted the immune response against the cancer. (nature.com)
The SQZ eAPC platform is the second-generation product candidate designed to generate tumor specific CD8+ T cell activation to drive the antitumor immune response. (stockhouse.com)
These findings may be linked to reports that MUC1 plays an important role in the impairment of cell-cell adhesion, the immune response, and/or altered intracellular signalling. (bmj.com)
Tumor antigens are hypothesized to evoke both a humoral and a cellular immune response that leads to blistering in mucosa and other epithelia. (medscape.com)
when it comes to cancer they are critical as they present tumor antigens to the killer cells of the immune system and orchestrate the anti-tumor immune response. (lu.se)

1 - 14 CA 27.29 also can be found in patients with benign disorders of the breast, liver, and kidney, and in patients with ovarian cysts. (aafp.org)
Patients continue to be enrolled in a Phase 2 trial evaluating nirogacestat in ovarian granulosa cell tumors. (biospace.com)

We demonstrated that the pro-apoptotic protein Bax can be presented by this pathway in cancer cells (7). (cardiff.ac.uk)
This peptide can originate from a protein that remains within the cell (Fig. 1). (wikipedia.org)
The expression level of MAGEC2 protein was significantly reduced when TRIM28 was depleted in tumor cells, and no changes were observed in MAGEC2 mRNA level. (biomedcentral.com)
Mechanistic studies indicate that the regulatory role of TRIM28 on MAGEC2 protein expression in tumor cells depends on proteasome-mediated pathway. (biomedcentral.com)
In this study, we found that expression of MAGEC2 protein in tumor cells depends on the expression of TRIM28, a reduction in the level of endogenous TRIM28 expression in melanoma cells resulting in significantly decreased expression of MAGEC2 protein. (biomedcentral.com)
We report that BM B cells isolated from RA patients express TLR9 at the mRNA and protein levels acquired at the stage of preB/immature B-cell maturation. (nih.gov)
Knockdown of MAGEA6 Activates AMP-Activated Protein Kinase (AMPK) Signaling to Inhibit Human Renal Cell Carcinoma Cells. (nih.gov)
An anticancer drug is coupled to an antibody that targets a specific tumor antigen (or protein ) that, ideally, is only found in or on tumor cells. (wikipedia.org)

Its SQZ TAC platform is designed to induce antigen-specific immune tolerance in vivo by utilizing a similar approach to the AAC platform. (stockhouse.com)
Vaccination-induced Trm cells were largely resistant to in vivo intravascular staining and antibody-dependent depletion. (lifeboat.com)

In February 2023, the U.S. Food and Drug Administration (FDA) accepted SpringWorks' New Drug Application (NDA) for nirogacestat, an investigational oral, small molecule gamma secretase inhibitor, in development as a monotherapy for the treatment of adults with desmoid tumors. (biospace.com)
In February 2023, the first patient was dosed in a Phase 1/2a combination study of BGB-3245 and mirdametinib. (biospace.com)

The patient whose cancer did not respond to treatment had early disease progression with CD19/CD20-negative disease by day 14 after infusion. (aacr.org)
Median progression-free and overall survival were not reached at the time of follow-up, and all responding patients continued to have CAR T-cell persistence at the time of data cutoff. (aacr.org)
CONCLUSION: These results suggest that MCM4 might be a useful predictive biomarker for high-grade histology, tumor progression and poor prognosis in UC. (bvsalud.org)

The objective of this proposal is to improve bispecific anti-CD20/anti-CD19 CAR T-cell activity and persistence by understanding impact of cell manufacturing parameters on final engineered CAR-T product and determining resistance mechanisms in relapsing patients. (lls.org)
In this study, Ghafouri and colleagues evaluated the safety and efficacy of anti-CD19/CD20 bispecific CAR T-cells using naïve memory cells. (aacr.org)
Naïve memory T cells were extracted from each patient, engineered to express an anti-CD19/CD20 CAR, expanded, and infused back into the patient at one of two different doses (either 5×10 7 cells or 2×10 8 cells). (aacr.org)
Although long-term follow-up and analysis of additional patients are needed, our results indicate that bispecific anti-CD19/CD20 CAR in naïve memory T cells may be safe and effective in patients with relapsed or refractory B-cell lymphomas," Ghafouri said. (aacr.org)

Other B-cell lymphomas could also potentially be treated using the vaccine, including multiple myeloma and chronic lymophocytic leukemia. (singularityhub.com)
Background Multiple myeloma (MM) is a rare cancer that leads to malignant plasma cells. (bmj.com)

In November, Adicet initiated an expansion cohort (EXPAND) to evaluate ADI-001 in patients with post CAR T LBCL and continues to enroll MCL patients in the Company's ongoing Phase 1 study of ADI-001. (businesswire.com)
The Phase 1 trial evaluating BGB-3245, a selective RAF dimer inhibitor, as a monotherapy in adult patients with RAF mutant solid tumors is advancing into cohort expansion studies. (biospace.com)
The compelling conclusion that proliferative exhausted T cells are associated with response in HPV+ head and neck cancer is supported by the cohort of 14 patients with paired tumor and adjacent normal tissue and rigorous bioinformatic analysis of nearly 50,000 single CD3+ T cell transcriptomes. (elifesciences.org)

The goal of this study was to determine whether myeloid suppressor cells producing high arginase existed in renal cell carcinoma patients. (aacrjournals.org)

Notably, among patients who relapsed after CAR20.19 treatment, CD19 loss was not identified, suggesting that dual antigen targeting may inhibit the mechanism of antigen escape. (lls.org)
1. Both the etiology and inducing mechanism of tumor are still under study at the present time. (qigonginstitute.org)

MCV immunoglobulin G levels phenotype in MCV-positive tumor cells ( 11 ), and the extent remained detectable up to 25 years after exposure. (cdc.gov)
Fig. 5: Change in phenotype and genotype of peripheral T cells after TIL infusion. (nature.com)
Exclusion criteria: (1) Acute mixed phenotype leukaemia (excluding ALL with myeloid antigen expression). (who.int)

We have shown that each colon neoplasm arises from a clonal expansion of one transformed cell. (hopkinsmedicine.org)

ICT-107 targets multiple tumor associated antigens. (genengnews.com)
The ACTolog approach targets tumor-specific antigens to fight cancer. (pharmacytimes.com)
We believe that attacking multiple cancer targets simultaneously using our tailored approach may lead to promising new treatment options for cancer patients with significant unmet medical need. (pharmacytimes.com)

They will obviously increase in the case of malignant tumor. (qigonginstitute.org)

Peripheral blood phenotyping data show increases in CD4+ and CD8+ T cell proliferation two weeks after anti-OX40 administration. (bepress.com)
Neoantigen-reactive T cell clonotypes increased and persisted in peripheral blood after treatment. (nature.com)
TRV-β sequencing of tumor and peripheral T cells as the project 'TIL trial for NSCLC' are available in the immuneACCESS free public database at https://clients.adaptivebiotech.com/immuneaccess . (nature.com)

Analyses of CD8+ TIL show increases in tumor-antigen reactive, proliferating CD103+ CD39+ cells in 25% of patients with evaluable tumor tissue (N = 4/16), all of whom remain disease-free. (bepress.com)
The routine method for detecting disseminated tumor cells in lymph nodes is microscopic examination of one or a few hematoxylin and eosin-stained tissue sections by a trained pathologist. (lu.se)
DESIGN: This study is a side-by-side comparison of biomarker mRNA analysis and histopathology of 185 lymph nodes from patients with colon cancer representing stages I to IV, and an investigation of the importance of lymph node tissue volume for tumor cell detection. (lu.se)
Now, Accentia Biopharmaceuticals and Biovest International have developed a non-Hodgkin's lymphoma (NHL) vaccine that teaches the body's immune system to identify and destroy tumor cells while leaving healthy tissue intact. (singularityhub.com)
Vaccines that can destroy lymphoma without destroying healthy tissue will be welcome news to millions of cancer patients. (singularityhub.com)

CONCLUSIONS: mRNA analysis of CEACAM5, KLK6, and SLC35D3 improves the detection of tumor cells in lymph nodes from patients surgically treated for colon cancer, and, together with POSTN and MUC2, it further allows characterization of the tumor cells with respect to aggressiveness and the tumor cell environment. (lu.se)

Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR. (ucl.ac.uk)
Blinatumomab is a bispecific T-cell engager (BiTE) targeting CD19 on malignant B cells and CD3 on normal host T cells. (hindawi.com)

However, most NMIBC patients will experience recurrence within 5 years, and a portion of patients will develop muscle-invasive bladder cancer (MIBC). (frontiersin.org)
The aim of DC vaccination is to boost cancer-specific effector T cells that can not only fight existing cancer but also induce immunological memory to control the recurrence of cancer. (nature.com)
In monitoring patients for disease recurrence, tumor marker levels should be determined only when there is a potential for meaningful treatment. (aafp.org)
BACKGROUND: Lymph node metastasis is the single most important prognostic risk factor for recurrence in patients with colon cancer who have undergone curative surgery. (lu.se)

Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
We investigated the expression of immune checkpoints (ICs) on lymphoid populations within the CRC TME and compared with cells from normal colon tissues using samples from 50 patients with varying disease stages. (mdpi.com)
However, little is known for the regulation of MAGEC2 expression in cancer cells. (biomedcentral.com)
Immunohistochemistry (IHC) staining was performed in hepatocellular carcinoma patients to evaluate the association between the expression of MAGEC2 and TRIM28. (biomedcentral.com)
We demonstrate that MAGEC2 interacts with TRIM28 in melanoma cells and MAGEC2 expression in tumor cells depends on the expression of TRIM28. (biomedcentral.com)
To our knowledge, this is the first time to report the role of TRIM28 in regulating the expression of cancer/testis antigen MAGEC2. (biomedcentral.com)
Moreover, RA BM B cells exerted higher expression of CD86 than their osteoarthritis counterparts, suggesting their in situ activation via TLR9. (nih.gov)
This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
The expression of MUC1, MUC2, MUC3, MUC5AC, and MUC6 was investigated immunohistochemically in gastric carcinoma (n = 46) in relation to patient clinicopathological features. (bmj.com)
1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
Results: No difference in antigen expression between normal and malignant endothelial cells (ECs) was found for CD54, CD109, CD137, CD141, CD144 and CXCR7. (researchgate.net)
Furthermore, expression of snail family transcriptional repressor 1 and cadherin 2 was significantly increased and that of cadherin 1 was significantly decreased in KIF18B siRNA-transfected GC cells. (bvsalud.org)
Moreover, MCM4 expression was significantly higher in the invasive front than in the tumor surface. (bvsalud.org)
ICC for MCM4 was also performed on urine cytology slides and showed that the nuclear expression of MCM4 was more frequently found in UC cells than in non-neoplastic cells. (bvsalud.org)
By using direct reprogramming strategies, I could induce the expression of tumor antigens on the surface of cancer cells, making them visible to the immune system again. (lu.se)
bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)
Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte pro- liferation. (cdc.gov)

Anatomy17

Organisms10

Diseases56

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment42

Phenomena and Processes39

Disciplines and Occupations1

Information Science4

Health Care6

Immunotherapy23

Chimeric antigen7

Receptor9

Antibodies12

Solid tumor5

Immunity13

Microenvironment2

Serum12

Monoclonal antibody5

Metastatic15

Autologous5

Head and neck squamous cell carc3

Proteins5

Clinical31

Cancers12

Markers14

Malignancies7

Induce antigen presentation3

Melanoma associated antigens1

Lymphocytes4

Cytotoxic T-lymphocy1

Colorectal cancer3

Germ cell t2

Biomarkers4

Responses16

Squamous cell carc2

Therapeutic9

Therapy40

Receptors2

Genes11

Dendritic cell3

Methods2

Lung14

Mutations7

Brain tumors2

Membrane antigen2

Prognosis of patients2

Peptides6

Patient's2

Anti-tumor mechanism1

Promoting tumor growth1

Cancerous3

Molecular5

Therapies5

Immune response5

Ovarian2

Protein8

Vivo2

20232

Progression3

CD204

Multiple Myeloma2

Cohort3

Suppressor1

Mechanism2

Phenotype3

Neoplasm1

Targets3

Malignant tumor1

Peripheral3

Tissue5

CONCLUSIONS1

CD192

Recurrence4

Expression17