Cells of epithelial cell adhesion molecules. Medical search. Frequent questions

BUD and FORM suppress RV-induced chemokines and growth factors in bronchial epithelial cells in a concentration-dependent, synergistic or additive manner. (nih.gov)
We have recently identified, for the first time, that bronchial epithelial cells are its novel cell source in response to IL-33 via ST2-ERK1/2-MSK1 signaling pathway. (hindawi.com)
Exposure of bronchial epithelial cells to aqueous extracts of hog CAFO dusts (HDE) leads to inflammatory cytokine production that is driven by protein kinase C (PKC) activation. (cdc.gov)
Bronchial epithelial cells were cultured with the short-acting β2-agonist salbutamol or the long-acting β2-agonist salmeterol prior to stimulation with HDE. (cdc.gov)
In primary cultures of human bronchial epithelial cells (HBECs) with 16.6±0.4 mM glucose in the basolateral medium, ASL glucose was 2.2±0.5 mM [ 11 ]. (ersjournals.com)
C. pneumoniae has been shown to infect many other cell types besides bronchial epithelial cells. (helsinki.fi)
To determine whether FP reduces cytokine production in bronchial epithelial cells via NF-κB, the authors investigated the nonstimulated and the Pseudomonas aeruginosa lipopolysaccharide (LPS) stimulated production of NF-κB-dependent interleukin (IL)-6, IL-8 and RANTES (regulated on activation, T-cell expressed and secreted) along with the activation of NF-κB in non-CF and CF human bronchial gland epithelial cells. (ersjournals.com)
It was demonstrated that a relevant concentration of FP (10 −8 M) inhibited constitutive and P. aeruginosa LPS-induced IL-6 and IL-8 production of non-CF and CF bronchial epithelial cells. (ersjournals.com)
Interestingly, the expression of two IκB kinases (IKK)-α/β, the degradation of cytosolic IκB-β inhibitor and the NF-κB deoxyribonucleic acid binding activity were markedly reduced after FP treatment in both CF and non-CF bronchial epithelial cells. (ersjournals.com)
It was shown by the authors that fluticasone propionate exerts an anti-inflammatory effect by blocking a signal transduction leading to a reduced level of IκB-α/β kinases in bronchial epithelial cells. (ersjournals.com)
In particular the strong effect on the IκB-β kinase, which is known to be elevated in bronchial epithelial cells in cystic fibrosis patients, was observed. (ersjournals.com)
The present authors and previous studies, have previously demonstrated that epithelial expression of interleukin (IL)-8 is excessively elevated in the bronchial epithelial cells of human CF adults 6 . (ersjournals.com)

Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell-cell adhesion in epithelia. (wikipedia.org)
Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E. Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. (wikipedia.org)
in fact, EpCAM is expressed in a variety of human epithelial tissues, carcinomas, and progenitor and stem cells. (wikipedia.org)
However, EpCAM is not found in non-epithelial cells or cancers of non-epithelial origin. (wikipedia.org)
Expression levels are substantially higher in small intestine, and in colon EpCAM is probably expressed at the highest levels among all epithelial cell types. (wikipedia.org)
EpCAM is frequently upregulated in carcinomas but is not expressed in cancers of non-epithelial origin. (wikipedia.org)
In cancer cells, EpCAM is expressed in a dispersed pattern across the cell membrane. (wikipedia.org)
some cells in a tumor have more EpCAM than other cells in the same tumor. (wikipedia.org)
Squamous carcinomas often express EpCAM whereas normal squamous cells do not express EpCAM. (wikipedia.org)
EpCAM expression differs between different types of renal cell carcinomas, and EpCAM expression increases during development of androgen resistance in prostate cancer. (wikipedia.org)
Although it is identified as a cell adhesion molecule, EpCAM does not structurally resemble any of the four major families of cell adhesion molecules, namely cadherins, integrins, selectins, and members of the immunoglobulin super-family. (wikipedia.org)
The sequence of the EpCAM molecule predicts the presence of three potential N-linked glycosylation sites. (wikipedia.org)
EpCAM was first found to play a role in homotypic cell adhesion. (wikipedia.org)
This means that EpCAM on the surface of one cell binds to the EpCAM on a neighboring cell thereby holding the cells together. (wikipedia.org)
The adhesions mediated by EpCAM are relatively weak, as compared to some other adhesion molecules, such as classic cadherins. (wikipedia.org)
EpCAM mediates intercellular adhesion and associates with the actin cytoskeleton via EpICD. (wikipedia.org)
EpCAM has a negative impact on cadherin-mediated adhesions. (wikipedia.org)
Active proliferation in a number of epithelial tissues is associated with increased or de novo EpCAM expression. (wikipedia.org)
Recently, a number of researchers reported that CTCs tend to lose their epithelial cell adhesion molecule (EpCAM) by an epithelial-mesenchymal transition (EMT). (rsc.org)
This protein was linked to biotinylated epithelial-cell adhesion-molecule antibodies (anti-EpCAM), which can bind human breast cancer cells. (chemistryviews.org)
Specifically, an antibody to the surface epithelial cell adhesion molecule (epCAM) identifies cells of epithelial origin circulating within the blood. (biomedcentral.com)
The cell surface molecules EpCAM, PVR and CD73 are overexpressed on CAISMOV24 cells compared to the primary malignant cells. (biomedcentral.com)

Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule antibody against pancreatic carcinoma. (uni-heidelberg.de)

Additionally, cytokeratin antibodies further distinguish CTCs as those that are not white blood cells (i.e. (biomedcentral.com)
Epithelial cells are isolated from peripheral blood using antibodies to Ep-CAM conjugated to magnetic particles. (biomedcentral.com)
it furnishes a wide array of molecules that restrict microbes, such as antibodies, bactericidins, and inhibitors of bacterial adherence. (lu.se)

These proteins are localized in the tight junctions between endothelial cells or epithelial cells. (rndsystems.com)
JAM-B, alternatively named vascular endothelial JAM (VE-JAM), is expressed prominently on high endothelial venules of lymphoid organs where it is localized to the intercellular boundaries of high endothelial cells. (rndsystems.com)
OVDs can create and preserve surgical space, pressurize the anterior chamber in the presence of an open wound, partition spaces, protect the corneal endothelial cells from fluid turbulence, and facilitate surgery. (lww.com)
Carcinoembryonic antigen (CEA) is glycoprotein associated with various functions of endothelial cells, including adhesion, proliferation, and migration. (degruyter.com)
These cells include monocytes, macrophages and vascular endothelial cells. (helsinki.fi)
On the other hand, Rab27b may play a key role in the communication between ESC and endothelial cells, by simulating VEGF secretion and neovascularization. (bvsalud.org)
This development occurs under the influence of macrophage colony-stimulating factor (M-CSF), which is secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)

Salbutamol treatment significantly reduced HDE-induced intracellular adhesion molecule-1 expression and neutrophil adhesion to epithelial cells. (cdc.gov)
IL-17A enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. (thermofisher.com)
CD324 binds to the α E β 7 integrin to mediate cell adhesion and also interacts with a number of intracellular proteins including including erbin, ezrin, caspase-3, caspase 8, β-catenin, presenilin 1, casein kinase II , as well as other extracellular proteins including the EGF receptor. (biolegend.com)
Typical gross presentation of clear cell renal cell carcinoma (lower left) with golden color due to intracellular lipid accumulation. (medscape.com)
Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)

Nuclear factor-kappa B directs carcinoembryonic antigen-related cellular adhesion molecule 1 receptor expression in Neisseria gonorrhoeae-infected epithelial cells. (mpg.de)

It inhibits binding of intercellular adhesion molecule-1 (ICAM-1) to LFA-1 and has been effective in reducing ocular surface inflammation. (aao.org)

These three cytokines are differentially expressed in activated CD4 + T cells. (hindawi.com)
C. pneumoniae induces the secretion of different kinds of cytokines and cell signalling molecules and the expression of adhesion molecules in all of these cell types. (helsinki.fi)
The aim of this study was to investigate the effect of anti-chlamydial compounds on the release of cytokines and cell signaling molecule, nitric oxide, induced by C. pneumoniae -infection in different cell types. (helsinki.fi)
The concentrations of cytokines in the cell medium were measured after infection using ELISA-method. (helsinki.fi)
In CF disease, a nonregulated inflammatory lung response occurs through exaggerated nuclear factor (NF)-κB activation and elevated pro-inflammatory cytokines production by airway epithelial cells. (ersjournals.com)
The effects of corticosteroids are predominantly mediated by the inhibition of NF-κB deoxyribonucleic acid (DNA)-binding activity, which controls genes encoding inflammatory cytokines, chemokines and adhesion molecules in respiratory epithelial cells 10 - 13 . (ersjournals.com)
FP induces apoptosis of eosinophils 18 and also reduces the production of several cytokines such as IL-1β, IL-6, IL-8 and RANTES (regulated on activation, T-cell expressed and secreted) by alveolar macrophages 19 and lymphocytes 20 , 21 . (ersjournals.com)
The anti-inflammatory compound curcumin inhibits Neisseria gonorrhoeae-induced NF-kappa B signaling, release of proinflammatory cytokines/chemokines and attenuates adhesion in late infection. (mpg.de)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)

Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth. (bmj.com)
Among the genes that remain deregulated during remission, we identify several that are expressed by epithelial cells and are involved in epithelial cell proliferation, resistance to apoptosis and response to stress. (bmj.com)
Microarray analysis reveals that inhibition of Notch signalling causes downregulation of stem cell-associated genes in parallel with decreased proliferation and increased numbers of ciliated cells and that organoids also respond to oestradiol and progesterone treatment in a physiological manner. (nature.com)
Rab27b can promote the cell proliferation, migration and invasion of ESCs. (bvsalud.org)
Gα12 couples to numerous G-protein-coupled receptors (GPCRs) and regulates multiple epithelial responses, including proliferation, apoptosis, permeability and the actin cytoskeleton. (medscape.com)

IL-23-dependent, IL-17A-producing CD4+ T cells (Th-17 cells) have been identified as a unique subset of Th cells that develops along a pathway that is distinct from the Th1- and Th2- cell differentiation pathways. (thermofisher.com)
The presence of 'stem cell-like' cells has previously been postulated based on sphere-forming capacity and differentiation in vitro 1 and evidence for the presence of label-retaining cells in the distal fallopian tube 2 . (nature.com)
Our data reveal a significant overlap between Notch-dependent genes in the fallopian epithelium and the defined 'stem cell signature' of the mouse intestine, suggesting the existence of a conserved pathway that regulates tissue renewal and directly controls cell fate specification and differentiation in the organoid by inhibiting cilliogenesis. (nature.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

In vitro models of RV infection of BEAS-2B and primary normal human bronchial epithelial (NHBE) cells were used. (nih.gov)
Phenotypic heterogeneity of retinal pigment epithelial cells in vitro and in situ. (nih.gov)
In vitro studies in resistive human lung epithelial cell monolayers grown at an air-liquid interface have supported these in vivo observations. (ersjournals.com)
A panel of esophageal cell lines was examined for the ability of TGF-β1 to induce EMT in vitro . (aacrjournals.org)
Recently, an in vitro study on the expression of ΔF508 CFTR (CFTR which contains a deletion of phenylalanine at position 508) in the ovary cells of Chinese hamsters, which do not express CFTR, revealed a seven-fold increase in the activation of NF-κB compared to the wild-type CFTR or the G551D mutant. (ersjournals.com)
We show that single epithelial stem cells in vitro can give rise to differentiated organoids containing ciliated and secretory cells. (nature.com)
Here we demonstrate the existence of adult stem cells in the human fallopian tube epithelium, which gives rise to a monolayer of differentiated epithelial cells in a complex 3D organoid in vitro . (nature.com)
The spontaneous immortalization of primary malignant cells is frequently assigned to their genetic instability during in vitro culturing. (biomedcentral.com)
The in vitro culture was established with cells isolated from ascites of a 60-year-old female patient with recurrent ovarian cancer. (biomedcentral.com)

Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)
Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus. (mpg.de)
These were examined the genome of dividing gastric epithelial 20% [12]. (who.int)

One of the major clinical manifestations of CFTR mutations is neutrophil dominated inflammation 2 , 3 , implying that defective CFTR affects the immune function of airway epithelial cells, in particular the production of nuclear factor (NF)-κB-dependent chemokines. (ersjournals.com)
Increasing evidence suggests that respiratory epithelial cells with dysfunctional CFTR have exaggerated activation of NF-κB/inhibitor of NF-κB complex associated with upregulated expression of chemokines 4 , 5 . (ersjournals.com)

Only a few of these rare malignant cells are typically found among millions of white blood cells and billions of red blood cells per milliliter of blood. (uh.edu)
Additionally, comparative genomic hybridization was employed to compare genomic alterations between the CAISMOV24 cell line and its primary malignant cells. (biomedcentral.com)
Although the cell line had developed alongside the accumulation of genomic alterations (28 CNV in primary cells and 37 CNV in CAISMOV24), most of them were related to CNVs already present in primary malignant cells. (biomedcentral.com)
Additionally, CAISMOV24 cell line was characterized as a low-grade serous ovarian carcinoma, which still resembles its primary malignant cells. (biomedcentral.com)
Its lethality is a consequence of the lack of symptoms or biomarkers enabling the early diagnosis of disease, and the propensity of malignant cells to seed the peritoneal cavity. (biomedcentral.com)
However, cell lines are known for their susceptibility to genetic and metabolic alterations, which can alter their characteristics in relation to the primary malignant cells. (biomedcentral.com)
Ideally, the more a cell line resembles the primary malignant cells, the more useful it will be for scientific research. (biomedcentral.com)
Clear cell renal cell carcinoma (CCRCC) is a renal cortical tumor typically characterized by malignant epithelial cells with clear cytoplasm and a compact-alveolar (nested) or acinar growth pattern interspersed with intricate, arborizing vasculature. (medscape.com)

A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
Cell Adhesion Mediated by JAM‑B/VE‑JAM and Neutral-ization by Human JAM‑B/ VE‑JAM Antibody. (rndsystems.com)
Adhesion elicited by Recombinant Human JAM-B/VE-JAM Fc Chimera (0.2 µg/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human JAM-B/ VE-JAM Monoclonal Antibody (Catalog # MAB10741). (rndsystems.com)

cAMP-dependent protein kinase (PKA)-activating agents can inhibit PKC activation in epithelial cells, leading to reduced inflammatory cytokine production following HDE exposure. (cdc.gov)
Interleukin-17A (IL-17A) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. (thermofisher.com)
Schisandra chinensis -lignans inhibited especially the release of nitric oxide in both C. pneumoniae -infected and LPS-stimulated cells which may tell about their broad anti-inflammatory properties. (helsinki.fi)

Nitric oxide and glucocorticoids synergize in inducing apoptosis of CD4+8+ thymocytes: Implications for "Death by Neglect" and T cell function. (uni-heidelberg.de)
Twenty-nine of these genes were significantly regulated in UC-in-remission subjects compared with non-IBD controls, including a large number of epithelial cell-expressed genes such as REG4, S100P, SERPINB5, SLC16A1, DEFB1, AQP3 and AQP8, which modulate epithelial cell growth, sensitivity to apoptosis and immune function. (bmj.com)
Finally, analysis of the mechanism by which multimeric alpha-lactalbumin induces apoptosis in transformed epithelial cells could lead to the design of antitumor agents. (lu.se)

Sukumar, S. HOXB7, a Homeodomain Protein, Is Overexpressed in Breast Cancer and Confers Epithelial-Mesenchymal Transition. (hopkinsmedicine.org)
First, when tumor cells get into the blood, they intend to undergo a biological change called epithelial-mesenchymal transition (EMT). (uh.edu)
There is increasing evidence that epithelial to mesenchymal transition (EMT) is involved in cancer progression. (aacrjournals.org)
As CTCs play a crucial role in tumor dissemination, translational research is implicating CTCs in several biological processes, including epithelial to mesenchymal transition. (biomedcentral.com)

Using spiked ovarian cancer cell lines (OVCAR-3) in blood as a model system, we were able to count the cells using a microcytometer with 88% efficiency with a flow rate of 13 μl min −1 without a dilution process. (rsc.org)
The epithelial lining of the fallopian tube is of critical importance for human reproduction and has been implicated as a site of origin of high-grade serous ovarian cancer. (nature.com)
In this study, the new epithelial ovarian cancer cell line CAISMOV24 was described and compared with its original low-grade serous ovarian carcinoma. (biomedcentral.com)

Evaluation of porcine mesenchymal stem cells for therapeutic use in human liver disease. (uni-heidelberg.de)
Using immunohistochemistry in a well-characterized set of adenocarcinoma tissues, we showed down-regulation of epithelial markers (E-cadherin and cytokeratin 18) and up-regulation of mesenchymal markers (vimentin and α-smooth muscle actin) with concomitant transforming growth factor-β1 (TGF-β1) expression at the invasive margin compared with the central tumor. (aacrjournals.org)

Too strong cytokine and immune response is detrimental to cells and to whole system. (helsinki.fi)

Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cancer stem-like cells acquire pronounced migratory potential. (uni-heidelberg.de)
Several studies have demonstrated that IL-17F plays a pivotal role in allergic airway inflammation and induces several asthma-related molecules such as CCL20. (hindawi.com)

Park, B.H. Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells. (hopkinsmedicine.org)

Current methods of detecting CTCs mainly rely on immunological detection of protein markers on the tumor cells. (uh.edu)
In TE7 cells, these TGF-β1-induced changes were reversed by 100 ng/mL of bone morphogenetic protein 7 (BMP7), another member of the TGF-β1 superfamily. (aacrjournals.org)
As test cases to examine changes in protein presence associated with tumor growth inhibition, we applied SILAC-based proteomics on human colon carcinoma cells treated with galectin-4 (Gal-4). (uni-muenchen.de)
By tracing significant alterations of protein expression likely relevant for the observed phenotypic effects, the capacity of a galectin to affect the proteome of human colon cancer cells at multiple sites is revealed. (uni-muenchen.de)
Many of these molecules activate G-protein-coupled receptors (GPCRs), which couple to multiple Gα subunits. (medscape.com)

At the core of AJs, cadherins mediate cell-cell adhesion through Ca 2+ -dependent homophilic interactions between their extracellular domains. (rupress.org)
Tumor-specific T cells are identified, expanded, and infused into the lymphodepleted patient, where they can help mediate tumor regression. (aacr.org)

Rescue of silenced UCHL1 and IGFBP4 expression suppresses clonogenicity of giant cell tumor- derived stromal cells. (uni-heidelberg.de)
Moreover, it exclusively detects live CTCs, and its detection efficacy is not impacted by the variation of epithelial cell adhesion molecule expression. (uh.edu)
TE7 cells were selected as a model because TGF-β1 (0-5 ng/mL) treatment induced morphologic and molecular expression changes suggestive of EMT. (aacrjournals.org)
The CAISMOV24 line was assessed for cell growth, production of soluble biomarkers, expression of surface molecules and screened for typical mutations found in serous ovarian carcinoma. (biomedcentral.com)

This approach has proven efficacious in some patients with epithelial cancers, and has been shown to synergize with checkpoint inhibition. (aacr.org)
Rosenberg is beginning to develop a library of TCRs that can recognize shared mutations in the hope of utilizing them for TCR T-cell therapy for patients across a variety of tumor types, especially those with common epithelial cancers. (aacr.org)
Circulating tumor cells (CTCs) are isolated tumor cells disseminated from the site of disease in metastatic and/or primary cancers, including breast cancer, that can be identified and measured in the peripheral blood of patients. (biomedcentral.com)
The serous histotype is responsible for almost 70% of epithelial ovarian cancers, which are additionally differentiated into low (type I) and high grades (type II). (biomedcentral.com)

Our results corroborate with the idea that genomic alterations, depicted by CNVs, can be used for subtyping epithelial ovarian carcinomas. (biomedcentral.com)

Glucose diffusion is determined by epithelial permeability to glucose, the transepithelial glucose gradient and surface area. (ersjournals.com)

CD324, a member of the cadherin superfamily, is a calcium-dependent, transmembrane cell-cell adhesion glycoprotein composed of 4 extracellular cadherin repeats and a highly conserved cytoplasmic tail region with a predicted molecular weight of approximately 100 kD. (biolegend.com)

The family of juctional adhesion molecules (JAM), comprising at least three members, are type I transmembrane receptors belonging to the immunoglobulin (Ig) superfamily (1, 2). (rndsystems.com)
Cystic fibrosis (CF) is a lethal inherited disorder caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) in airway epithelial cells 1 . (ersjournals.com)

The Epithelial Cell Adhesion Molecule has received increased attention as the main membrane marker used in many enrichment technologies to isolate circulating tumor cells (CTCs). (industryherald24.com)
CTCs, like the tumors they are originally detached from, lack unique and well-defined universal biomarkers highlighting the challenges of detection specificity," reports Dr. Shaun Zhang, M.D. Anderson Professor of biology and biochemistry and director of the Center for Nuclear Receptors and Cell Signaling. (uh.edu)
Quantification of circulating tumor cells (CTCs) in blood samples is believed to provide valuable evidence of cancer progression, cancer activity status, response to therapy in patients with metastatic cancer, and possible cancer diagnosis. (rsc.org)
Here, we describe a label-free DC impedance-based microcytometer for CTCs by exploiting the difference in size between CTCs and blood cells. (rsc.org)
As early as the 1800's when Recaimer first coined the term "metastasis", circulating tumor cells (CTCs) have been postulated to be critical to the process [ 5 , 6 ]. (biomedcentral.com)

These include the loss of proliferative control, enhanced cellular migration and invasion, extracellular matrix degradation, angiogenesis, lymphangiogenesis, and vascular invasion followed by the distant seeding of tumor cells in specific tissues, such as the liver or lung. (aacrjournals.org)
The constitutive photomorphogenesis 9 signalosome directs vascular endothelial growth factor production in tumor cells. (mpg.de)
Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. (cdc.gov)

IL-17F-induced CCL20 may attract Th17 cells into the airway resulting in the recruitment of additional Th17 cells to enhance allergic airway inflammation. (hindawi.com)
IL-17F is expressed in activated CD4 + T cells, basophils, and mast cells, three important cell types involved in allergic airway inflammation [ 3 ]. (hindawi.com)
In immortalised human airway cells (line H441) with 10 mM glucose in the basolateral medium, apical ASL glucose was 0.24±0.07 mM [ 10 ]. (ersjournals.com)
Inhaled fluticasone propionate (FP) is widely used to reduce pulmonary inflammation in chronic obstructive pulmonary disease, but the potential effects of FP on airway epithelial cells from patients with cystic fibrosis (CF) are unknown. (ersjournals.com)
How CFTR dysfunction in CF airway cells contributes to the activation and nuclear localisation of NF-κB is still unclear. (ersjournals.com)

These structures maintain apical Baz, accumulate apical Crumbs, and organize polarized cytoskeletons, but display abnormal cell morphology and fail to segregate the basolateral cue Discs large from the apical domain. (rupress.org)
Thus, although epithelial polarity develops in the absence of AJs, AJs play specific roles in maintaining epithelial architecture and segregating basolateral cues. (rupress.org)
AJs localize to the boundary between the apical and basolateral domains, and are thought to be critical landmarks for establishing epithelial polarity ( Nelson, 2003 ). (rupress.org)

Extracellular antigens (eg, from many bacteria) that are phagocytosed or endocytosed can be processed into peptides and complexed with surface class II MHC molecules on professional APCs, which specialize in presenting antigens to CD4 helper T (Th) cells. (msdmanuals.com)

Enrichment of c-Met+ tumorigenic stromal cells of giant cell tumor of bone and targeting by cabozantinib. (uni-heidelberg.de)
Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor. (thermofisher.com)
Primary endometrial stromal cells (ESCs), decidual stromal cells (DSCs), decidual immune cells (DICs) and peripheral blood mononuclear cells (PBMCs) were isolated. (bvsalud.org)

Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. (jcancer.org)
Here we report on the establishment of long-term, stable 3D organoid cultures from human fallopian tubes, indicative of the presence of adult stem cells. (nature.com)

Analysis of the type IV secretion system-dependent cell motility of Helicobacter pylori-infected epithelial cells. (mpg.de)

The hallmark effector molecules of Th1 and Th2 cells, e.g. (thermofisher.com)
Targeting activated Gα subunits to specific cells in vivo permits identification of downstream effector pathways independent of receptor activation, and thus permits insight into disease mechanisms otherwise impossible to study in vivo . (medscape.com)

High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells. (thermofisher.com)

In addition some of the compounds were tested for the cell viability using resazurin assay. (helsinki.fi)

There were four cell types used in this study, HL- and BEAS-2B-epithelial cells, THP-1-monocytes/macrophages and RAW264.7-macrophages. (helsinki.fi)
In women with miscarriage, NRP1 was abnormally elevated in DSCs but diminished in decidual macrophages and NK cells. (bvsalud.org)
Macrophages are phagocytic cells present in tissues throughout the body. (msdmanuals.com)

Some data support the hypothesis that changes in tear osmolality trigger corneal and conjunctival epithelial damage and initiation of dry eye. (aao.org)

Dendritic cells are present in the skin (as Langerhans cells), lymph nodes, and tissues throughout the body. (msdmanuals.com)

but in summary, the system uses serum enriched for nucleated cells expressing epithelial-cell adhesion molecules, and fluorescently labels them for eventual detection by semi-automated fluorescence-based microscopy. (biomedcentral.com)

Tumors in which eosinophilic cells predominate were previously classified as "granular cell" carcinoma but are currently included among CCRCCs in the 2004 World Health Organization classification of renal tumors based on the presence of vasculature and genetic alterations typical of CCRCC. (medscape.com)

Indeed, loss of epithelial cell polarity is associated with tumor development and metastasis. (rupress.org)

CD324 functions as a cell adhesion molecule involved in development, bacterial pathogenesis, and tumor invasion. (biolegend.com)
In bacterial pathogenesis, the ectodomain of CD324 mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is required for internalization. (biolegend.com)
While investigating the effect of human milk on bacterial adherence to a human lung cancer cell line, we were surprised to discover that the milk killed the cells. (lu.se)

The Center for Nuclear Receptors and Cell Signaling at the University of Houston has developed a new way to detect very rare and highly heterogeneous circulating tumor cells with high specificity and sensitivity. (uh.edu)
Dr. Shaun Zhang, M.D. Anderson Professor of biology and biochemistry and director of the Center for Nuclear Receptors and Cell Signaling, invented the UniPro which finds rare circulating tumor cells. (uh.edu)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

Therefore, we hypothesized that CRC cancer stem cell markers (CRCSC) will identify a group of patients at high risk for progression. (jcancer.org)

Shutao Wang, Chinese Academy of Sciences, Beijing, and colleagues have developed hydrogel coatings that can capture and release cancer cells. (chemistryviews.org)
Smart Thin Hydrogel Coatings Harnessing Hydrophobicity and Topography to Capture and Release Cancer Cells , Luying Wang, Hongliang Liu, Feilong Zhang, Guannan Li, Shutao Wang, Small 2016 . (chemistryviews.org)

In this study, we intended to investigate the impact of Rab27b and its downstream molecule in the development of EMS. (bvsalud.org)

Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)

For the treatment of ocular surface diseases such as persistent epithelial defects, superior limbic keratoconjunctivitis, keratoconjunctivitis sicca, and neurotrophic keratopathy, autologous serum eyedrops are beneficial. (aao.org)
Recombinant LASV-Josiah, based on the sequence of an isolate obtained in 1976 from the serum of a 40-year-old man hospitalized at Songo Hospital in Sebgwena, Sierra Leone ( 21 , 22 ), was rescued in BSR-T7/5 cells and passaged twice in Vero-E6 cells (GenBank accession nos. (cdc.gov)

As the inflammation continues to destroy more of these bile ducts, it spreads to destroy nearby liver cells (hepatocytes). (emedicinehealth.com)
The combined effects of progressive inflammation, scarring, and toxicity of bile trapped within hepatocytes (liver cells) culminate in cirrhosis. (emedicinehealth.com)

Zhang's research team includes Xinping Fu and Lihua Tao, both from the Department of Biology and Biochemistry and Center for Nuclear Receptor and Cell Signaling at UH. (uh.edu)
Several types of ACT round out the immunotherapy arsenal, including chimeric antigen receptor (CAR) T-cell therapy, T-cell receptor (TCR) therapy, and tumor-infiltrating lymphocyte (TIL) therapy. (aacr.org)

Measured by its ability to neutralize JAM‑B/VE‑JAM-mediated adhesion of the J45.01 human acute lymphoblastic leukemia T lymphocyte cell line. (rndsystems.com)
Recombinant Human JAM-B/VE-JAM Fc Chimera (Catalog # 1074-VJ ), immobilized onto a microplate previously coated with Goat Anti-Human IgG Fc (Catalog # G-102-C ), supports the adhesion of the J45.01 human acute lymphoblastic leukemia T lymphocyte cell line in a dose-dependent manner (orange line), as measured by endogenous cellular lysosomal acid phosphatase activity. (rndsystems.com)

Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment. (uni-heidelberg.de)

Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)
Follicular dendritic cells are a distinct lineage (a different cell type than conventional dendritic cells), do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)

As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
Unfortunately, patients are already in the terminal stage at this time, and the cancer cells have already invaded the surrounding organs or metastasized far away, which leads to the loss of the curative chance for most patients ( 1 ). (frontiersin.org)
The hydrogel can capture cancer cells at 37 °C, since its surface "collapses" and develops nanowrinkles, which improve cell adhesion by providing a larger contact area (pictured). (chemistryviews.org)
This treatment utilizes a patient's own immune system to recognize and attack cancer cells. (aacr.org)

Anatomy50

Organisms10

Diseases11

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes45

Disciplines and Occupations1

Information Science3

Bronchial epithelial cells12

EpCAM22

Anti-epithelial cell adhesion1

Antibodies3

Endothelial cells7

Intracellular5

Carcinoembryonic antigen-related1

Intercellular1

Cytokines9

Proliferation5

Differentiation5

Vitro9

Gastric3

Chemokines2

Malignant8

Antibody3

Inflammatory3

Apoptosis3

Transition4

Ovarian cancer3

Mesenchymal2

Cytokine1

Induces2

Interleukin1

Protein5

Mediate2

Expression4

Cancers4

Carcinomas1

Permeability1

Glycoprotein1

Transmembrane2

CTCs5

Vascular3

Airway5

Basolateral3

Extracellular1

Stromal cells3

Stem cells2

Secretion1

Effector2

Peripheral blood1

Viability1

Macrophages3

Corneal1

Tissues1

Detection1

Alterations1

Tumor development1

Bacterial3

Receptors3

Markers1

Wang2

Downstream1

Antigen-prese1

Serum2

Inflammation2

Receptor2

Acute2

Tumour1

Dendritic Cells2

Cancer cells4