Cells mechanotransduction cellular. Medical search. Frequent questions

These characteristics are summarized by: differentiation, cell division (mitosis), apoptosis (or "cell suicide") and cell death. (wikipedia.org)
This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)
This occurs naturally through a process known as mechanotransduction, which is the conversion of mechanical factors into biochemical changes, and can influence cellular functions such as proliferation, differentiation, migration, and apoptosis. (washington.edu)
I will present some of the work done on the detection of metabolites released by cells undergoing osteogenic differentiation and on the development of 3D architectures that can be used to host and monitor stem cells. (gla.ac.uk)
Building upon this work we are exploring the differentiation of embryonic and adult stem cells for articular cartilage and bone repair. (ucdavis.edu)
Matrix stiffness is a key determinant of mesenchymal stem cell (MSC) differentiation, suggesting that modulation of alginate bioink mechanical properties represents a promising strategy to spatially regulate MSC fate within bioprinted tissues. (nature.com)
It is a highly biocompatible hydrogel whose physical properties can potentially be tailored to direct 3D cell growth and differentiation both in vitro and in vivo 10 , 11 , 12 . (nature.com)
The goal is to characterize the dynamic flow conditions which drive endothelial cell mechanotransduction, cellular growth, and morphological maturation, as well as the differentiation of ADSCs into endothelial-like phenotypes. (aps.org)
Recent studies also suggest that cellular mechanical properties may provide novel biological markers, or 'biomarkers,' of cell phenotype, reflecting specific changes that occur with disease, differentiation, or cellular transformation. (duke.edu)
BMP‐6 loaded polyelectrolyte complex nanoparticles inducing osteogenic differentiation and apoptosis of malignant plasma cells for local treatment of multiple myeloma. (mpg.de)
Controllable ligand spacing stimulates cellular mechanotransduction and promotes stem cell osteogenic differentiation on soft hydrogels. (mpg.de)
The group aims to understand the mechanisms of morphogenesis and cell differentiation within an embryo. (royalsociety.org)
The current research focus is on the Dchs1-Fat4-PCP-Hippo signaling pathway and the role of mechanics during cell differentiation. (royalsociety.org)
In this work, for the first time, we adopt a multidisciplinary approach to characterize the morphological, biochemical, and molecular changes underlying the response of human bone marrow stromal cells to long-term simulated microgravity exposure during osteogenic differentiation. (lu.se)
We found novel proteins were dysregulated under simulated microgravity, including CSC1-like protein, involved in the mechanotransduction of pressure signals, and PTPN11, SLC44A1 and MME which are involved in osteoblast differentiation pathways and which may become the focus of future translational projects. (lu.se)

The mechanical properties of single cells play important roles in regulating cell-matrix interactions, potentially influencing the process of mechanotransduction. (duke.edu)

Whereas the mechanisms activating mechanotransduction are well studied, the reversibility of this process, whereby cells disassemble and reverse force-activated signalling pathways upon cessation of mechanical stimulation is far less understood. (ibecbarcelona.eu)
Applying a mechanical load to muscle, as is done during mechanotherapy treatment, influences muscle cell behavior via several molecular "mechanotransduction pathways" that also affect stem cells. (harvard.edu)
We showed that although aged stem cell behavior was disrupted by the elevated inflammation, they were still able to 'feel' the mechanical forces of loading as we demonstrated by the activation of these pathways," said first-author Stephanie McNamara , who is a graduate student on Mooney's team and currently enrolled in the joint Harvard/MIT MD-PhD program. (harvard.edu)
The process of mechanotransduction in fibroblasts involves several signaling pathways, including those mediated by integrins (cell surface receptors that bind ECM components), and can lead to changes in cell behavior. (nehcacademy.com)
These findings warrant future investigations into how the regulation of mechanotransduction pathways can be harnessed to prevent chemoresistance and signaling dysfunction. (umd.edu)

The three key elements of regenerative medicine and tissue engineering are morphogenetic signals, stem cells, and scaffolds of extracellular matrix. (ucdavis.edu)
Her lab further discovered a novel Twist1-G3BP2 mechanotransduction signaling pathway that senses physical forces exerted by extracellular matrix in the tumor microenvironment to generate biochemical and cellular responses that drive EMT and tumor metastasis (Wei et al, Nature Cell Biology, 2015). (aspet.org)
Fibroblasts and Extracellular Matrix: Fibroblasts are the primary cell type in connective tissues like fascia, and they play a pivotal role in the production and remodeling of the extracellular matrix (ECM). (nehcacademy.com)
A type of cell that synthesizes the extracellular matrix and collagen, which are crucial for tissue repair and maintenance. (nehcacademy.com)

This process is known as mechanotransduction and plays a fundamental role in the progression of solid tumours, such as breast cancer. (ecancer.org)

Mechanotransduction mechanisms whereby periodontal ligament stem cells (PDLSCs) translate mechanical stress into biochemical signals and thereby trigger osteogenic programs necessary for alveolar bone remodeling are being deciphered. (biomedcentral.com)
The concept of mechanotransduction, where cells translate mechanical stimuli into biochemical signals, is integral to understanding how mechanical vibrations can influence tissue remodeling. (nehcacademy.com)
These forces are detected by cellular mechanoreceptors, and subsequently converted into biochemical signals. (nehcacademy.com)
Maintaining cell water homeostasis is driven by the transport of water to balance solute concentration and can have direct consequences on mechanics and biochemical signaling in cells. (umd.edu)

Polyurethane vascular grafts were modified with gelatin and collagen to enhance endothelial cell adhesion and were modified using heparin to reduce thrombogenesis. (uwaterloo.ca)
In vitro investigation of human umbilical vein endothelial cell (HUVEC) and adipose-derived stem cell (ADSC) responses in a biomimetic 3D bioprinted blood vessel model under complex physiological flows was performed. (aps.org)

The process by which cells convert mechanical stimuli into a chemical response. (umassmed.edu)
The lab uses high speed fluorescent microscopy to determine responses of single cells and tissues to mechanical and chemical stimuli. (mayo.edu)
Mechanotransduction refers to the cellular responses to mechanical stimuli. (uwaterloo.ca)
How cells sense and respond to these mechanical stimuli requires an understanding of the biophysical principles that underlie changes in protein conformation and result in alterations in the organization and function of cells and tissues. (escholarship.org)

It can occur in both cells specialized for sensing mechanical cues such as MECHANORECEPTORS, and in parenchymal cells whose primary function is not mechanosensory. (umassmed.edu)
Dasgupta I, McCollum D. Control of cellular responses to mechanical cues through YAP/TAZ regulation. (umassmed.edu)
Seo YJ, Jothikumar P, Suthar MS, Zhu C , Grakoui A (2016) Local Cellular and Cytokine Cues in the Spleen Regulate In Situ T Cell Receptor Affinity, Function, and Fate of CD8+ T Cells. (meduniwien.ac.at)
A limitation of current TE strategies is their relatively poor spatial control of the distribution of cells, matrix components and bioactive cues within the engineered construct 1 . (nature.com)
We recently demonstrated a new mode of collective cell guidance by mechanical cues, called collective durotaxis. (ibecbarcelona.eu)
Mechanical forces and biophysical cues regulate diverse cellular functions and our aim is to elucidate the mechanisms by which cells sense and respond to these signals. (peerj.com)
When cell-adhesion-promoting peptide cRGDfK is selectively coupled to gold nanoparticles, the surfaces provide cues for cell-surface interaction and allow for the study of the modulation of cellular adhesion by the mechanical properties of the environment. (cipsm.de)
These problems can be partially circumvented by using macroporous biomaterials that improve the survival of transplanted stem cells and provide molecular cues to direct cell phenotype. (nature.com)
Our findings show that biophysical cues can be harnessed to direct therapeutic stem cell behaviours in situ . (nature.com)

Epithelial cells are contiguous and polarized. (wikipedia.org)
Adherens junctions (AJs) allow cell contact to inhibit epithelial migration yet also permit epithelia to move as coherent sheets. (ibecbarcelona.eu)
Here, we show that in human epithelial cells this arises from the orientation of cortical flows at AJs. (ibecbarcelona.eu)
Accurate fluid pressure in the fetal lung is critical for its development, especially at the beginning of the saccular stage when alveolar epithelial type 1 (AT1) and type 2 (AT2) cells differentiate from the epithelial progenitors. (lu.se)
By combining these technologies with computational analysis of cell shape and velocity we obtain a full experimental characterization of epithelial dynamics during tissue growth, wound healing and cancer cell invasion. (ibecbarcelona.eu)
We focus on the interaction between epithelial cancer cells and Cancer Associated Fibroblasts (CAFs), the most abundant cell type in the tumour stroma. (ibecbarcelona.eu)
As a postdoctoral fellow, Dr. Yang discovered that the transcription factor Twist1 and the Epithelial-Mesenchymal Transition (EMT) program play essential roles in tumor metastasis (Yang et al, Cell, 2004). (aspet.org)
She discovered that carcinoma cells undergo EMT to invade and disseminate from the primary tumor, but upon reaching distant sites, tumor cells need to revert to an epithelial state to form macrometastases (Tsai et al, Cancer Cell, 2012). (aspet.org)
We investigated the presence of aluminium (Al) in human colon cancer samples and its potential association with biological processes involved in cancer progression, such as epithelial to mesenchymal transition (EMT) and cell death. (bvsalud.org)
were used in the development of a human immunocompetent Organ-on-Chip - a human cell-based in vitro model of the choroid layer of the eye integrating melanocytes and microvascular endothelial cells, covered by a layer of retinal pigmented epithelial cells. (ilexlife.com)
Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility. (mpg.de)
Tuning epithelial cell-cell adhesion and collective dynamics with functional DNA-E-Cadherin hybrid linkers. (mpg.de)

Extracellular signal-regulated kinase (ERK) is a part of the mitogen-activated protein kinase (MAPK) signaling pathway which allows the transduction of various cellular signals to final effectors and regulation of elementary cellular processes. (mdpi.com)

Development of new or improved laboratory/experimental techniques, instruments, or supporting software that measure the location and dynamics of molecules in situ, and organelles, cells, or tissues on the nanometer and micrometer length scales. (nih.gov)
Moreover, these properties and responses can serve as mechanical signatures that allow us to diagnose diseased states in our cells and tissues. (washington.edu)
Our bodies can be viewed as a hierarchical system where our organs are composed of different tissues, which are defined by cells and the properties of the proteins they express. (washington.edu)
In recent years, the lab has identified stem and progenitor cells in articular cartilage, muscle and synovial tissues. (ucdavis.edu)
We develop new technologies to map and perturb the main physical properties that determine how cells and tissues grow, move, invade and remodel. (ibecbarcelona.eu)
These findings will help more accurately model the cellular mechanical environment in mesenchymal tissues, which could assist in describing injury thresholds and disease progression or even determining the influence of mechanical loading for tissue engineering efforts. (duke.edu)
Mechanical Stimulation and Cellular Response: During mechanical vibrations, tissues are subjected to oscillating pressures. (nehcacademy.com)
The clinical implications of mechanotransduction in fascial tissues. (nehcacademy.com)
A non-cellular component present within all tissues and organs that provides necessary support to cells. (nehcacademy.com)
The results of the study, led by Pere Roca-Cusachs, the principal investigator at the Institute of Bioengineering of Catalonia (IBEC) and the University of Barcelona, indicate that laminin, a protein that provides structure and support to healthy breast tissues, hinders the mechanotransduction process in cells, thereby protecting the nucleus from deformation. (ecancer.org)
To study the mechanotransduction process, the research team cultured breast tissue cells on gels with varying stiffness to mimic both healthy (soft) and malignant (stiff) tissues. (ecancer.org)

IH develop at the distal anastomosis of the graft and are due to over proliferation and abnormal migration of vascular smooth muscle cells (VSMC). (uwaterloo.ca)
Compliance mismatch forces the cells around the anastomosis to be exposed to abnormal mechanical stimulation, which is translated to biological responses to increase proliferation and migration of VSMC. (uwaterloo.ca)
Post-facto analysis was performed on dissected vessels using confocal microscopy techniques, live/dead staining, and polymerase chain reaction (PCR) testing to probe cellular growth and proliferation indicators. (aps.org)
Interference with and overproduction of GRP78 in vitro impacted the proliferation, migration, invasion, and metastasis of HCC cells. (bvsalud.org)
Figure 2: Manipulating stem cell osteogenesis and proliferation by controlling the elasticity of the bulk phase of void-forming hydrogels. (nature.com)
Ultimately, this nuclear deformation activates genes responsible for controlling cell proliferation, which are closely associated with tumour growth. (ecancer.org)
Additionally, this stiffness leads to the activation of the YAP protein, which enters the nucleus and initiates the expression of genes linked to cell proliferation. (ecancer.org)

We leveraged Caenorhabditis elegans ' touch receptor neurons as a simple model amenable to in vivo whole-cell patch-clamp recording and an integrated experimental-computational approach to dissect the mechanisms underlying the spatial and temporal dynamics we observed. (nih.gov)
The Gastrointestinal Mechanotransduction Laboratory provides career opportunities for researchers interested in molecular mechanisms of mechanosensation. (mayo.edu)
She elucidated the mechanisms through which these mutations cause hearing deficits, thus illuminating the unique biology of hair cells and informing deafness diagnosis and counseling. (bna.org.uk)
Collectively the breakthroughs made by this year's Kavli Prize laureates have unveiled the molecular and cellular mechanisms that underlie hearing and deafness. (bna.org.uk)
His group studies the physical and molecular mechanisms by which cells detect and respond to mechanical signals. (ibecbarcelona.eu)

Girish Ramaswamy, PhD Postdoc, 2012-2016: Ablation of Gsa signaling in osteoclast progenitor cells adversely affects skeletal bone maintenance. (upenn.edu)
The goal of this study was to determine the elastic and viscoelastic properties of three primary cell types of mesenchymal lineage (chondrocytes, osteoblasts, and adipocytes) and to test the hypothesis that primary differentiated cells exhibit distinct mechanical properties compared to adult stem cells (adipose-derived or bone marrow-derived mesenchymal stem cells). (duke.edu)
The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells. (nature.com)
A classic example of mechanotransduction in action is bone adapting to load. (bmj.com)
A small, relatively weak bone can become larger and stronger in response to the appropriate load through the process of mechanotransduction. (bmj.com)

ECM is a mixture of cells (immune, fibroblasts, etc.) dispersed in proteins, most of them collagen. (wikipedia.org)
By miniaturizing the tool, we can probe the role of cell mechanics at the length scale appropriate to the size of cells and their proteins. (washington.edu)
The communication at each stage occurs via cell signalling-an information network of messenger proteins, ion channels and lipids. (bmj.com)
They compared the behaviour of the cells on gels coated with laminin to those on gels coated with collagen or fibronectin, which are other cell-supporting proteins that are overproduced in carcinogenic processes. (ecancer.org)
The investigation of cell proteome highlighted how simulated microgravity affects a relatively low number of proteins compared to time and/or osteogenic factors and has allowed us to reconstruct a hypothetical pipeline for cell response to simulated microgravity. (lu.se)

Indeed, as shown in the table above, the study of mechanotransduction, which is the support of mechanobiology, uses a mechanical "input" (signal input) but the signal collected at the output (the "output") is biological. (wikipedia.org)
Yongho Bae, assistant professor of pathology and anatomical sciences, Jacobs School of Medicine and Biomedical Sciences, is principal investigator on the one-year, $639,543 study titled "Biomimetic Vascular Matrix for Vascular Smooth Muscle Cell Mechanobiology and Pathology. (buffalo.edu)

The appearance of cancer is signified by the crossing of the basement membrane to the underlying connective tissue by one or more cancer cells. (wikipedia.org)
The tissue phenotype - here cancerous tissue - is the sum of the cellular and tissue phenotype. (wikipedia.org)
Su Chin Heo (multiple principal investigator), Perelman School of Medicine, University of Pennsylvania, single-cell analysis/tissue engineering. (buffalo.edu)
The scope of the systems covered ranges from cellular to tissue, organ, systems studies, and up to populational dynamics. (nih.gov)
If we can understand how cells are guided by mechanics, then we can alter or direct cellular properties and responses in order to influence large changes in tissue and organs. (washington.edu)
TE strategies typically incorporate cells, biomaterials and signals (e.g. growth factors), with the goal of developing a construct that once implanted will promote tissue regeneration. (nature.com)
Here, we discuss mechano-transduction as it applies to protein conformation, cellular organization, and multi-cell (tissue) function. (escholarship.org)
To study cell and tissue dynamics we develop new technologies to measure physical forces at the cell-cell and cell-matrix interface. (ibecbarcelona.eu)
Surprisingly, some cells in the tissue barely stretch, while others become 'superstretched', increasing their area more than ten times. (ibecbarcelona.eu)
In search for an explanation for these results, the team found that mechanotherapy amplified rather than alleviated inflammation in aged muscle, ultimately hindering the normal healing process by disrupting the behavior of muscle stem cells, a subset of cells responsible for replacing damaged muscle tissue. (harvard.edu)
The role for mechanical stimulation in the control of cell fate has been previously proposed, suggesting that there may be a role of mechanical conditioning in directing mesenchymal stromal cells (MSCs) towards specific lineage for tissue engineering applications. (um.edu.my)
His research focuses on the modulation of immune system for the treatment of immune-based diseases with particular focus on type 1 diabetes, transplantation (cell, tissue, and solid organs), and cancer immunoprevention and immunotherapy. (lidsen.com)
The research conducted by central investigators is quite broad, ranging from cell and molecular biology to tissue engineering, biophysics and nanobiology/medicine. (upenn.edu)
After first outlining the process of mechanotransduction, we provide well-known clinical therapeutic examples of mechanotherapy-turning movement into tissue healing. (bmj.com)
To simplify this for patients, these same elements can be thought of as (1) the mechanical trigger or catalyst, (2) the communication throughout a tissue to distribute the loading message and (3) the response at the cellular level to effect the response-that is, the tissue "factory" that produces and assembles the necessary materials in the correct alignment. (bmj.com)
This anisotropy may significantly influence the cells' mechanotransductive response to complex loads, and has important implications for development of accurate models of tissue biomechanics. (asme.org)
Here, we describe a cellular microbiaxial stretching (CμBS) method that modifies this tissue-scale approach to measure the anisotropic elastic behavior of individual vascular smooth muscle cells (VSMCs) with nativelike cytoarchitecture. (asme.org)
The stiffness of breast tissue triggers a chain reaction, inducing tension within cells and distorting their nuclei. (ecancer.org)
It has already been demonstrated that an increase in tissue stiffness triggers mechanical responses within cells. (ecancer.org)

This includes a wide range of complementary techniques and expertise in molecular biology and cellular signalling, glycobiology , and structural biology and is underpinned by a wide range of national and international collaborations and access to world-leading Central Facilities including Institute Laue Langevin ( Life Sciences Group and Deuteration Laboratory ), Diamond Light Source and Harwell Campus , Liverpool Technology Directorate and Midlands Innovation . (keele.ac.uk)
O ur mission is to understand how mechanics affects human biology and disease at the fundamental level of biological cells. (washington.edu)
Directed cell migration is one of the earliest observations in cell biology, dating back to the late XIX century. (ibecbarcelona.eu)
Dr. Yang obtained her PhD in Molecular Cancer Biology from Duke University's Graduate Program in Cell and Molecular Biology, Department of Pharmacology and Cancer Biology in 1999. (aspet.org)
Philippa Francis-West is a Professor in Developmental and Cell Biology at the Centre for Craniofacial and Regenerative Biology, King's College London. (royalsociety.org)
Nature Cell Biology. (lu.se)

Extending from each hair cell is a bundle of fine processes that act as sensors. (bna.org.uk)
Both processes are the result of a complex interaction between tumor cells and their microenvironment. (ibecbarcelona.eu)
Although previous studies have reported that calcium signalling is involved in regulating many cellular processes in many cell types, its role in managing cellular responses to tensile loading (mechanotransduction) of MSCs has not been fully elucidated. (um.edu.my)
In conclusion, the knowledge gained in this study by elucidating the role of calcium in MSC mechanotransduction processes, and that in prolonged stretching results in non-apoptosis mediated cell death may be potential useful for regenerative medicine applications. (um.edu.my)
Stem cell behaviour can also be controlled in vitro by manipulating the elasticity of both porous and non-porous materials, yet translation to therapeutic processes in vivo remains elusive. (nature.com)
Differentially expressed miRNAs regulate multiple processes, including neuronal cell death and neuron formation. (bvsalud.org)

Mechanotransduction is the physiological process where cells sense and respond to mechanical loads. (bmj.com)
The one-word answer is "mechanotransduction", but rather than finishing there and limiting this paper to 95 words, we provide a short illustrated introduction to this remarkable, ubiquitous, non-neural, physiological process. (bmj.com)

The effectiveness of stem cell therapies has been hampered by cell death and limited control over fate. (nature.com)
Here, by developing injectable, void-forming hydrogels that decouple pore formation from elasticity, we show that mesenchymal stem cell (MSC) osteogenesis in vitro , and cell deployment in vitro and in vivo , can be controlled by modifying, respectively, the hydrogel's elastic modulus or its chemistry. (nature.com)
Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. (nature.com)
Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness. (nature.com)
Scadden, D. T. The stem-cell niche as an entity of action. (nature.com)
Khetan, S. & Burdick, J. A. Patterning network structure to spatially control cellular remodeling and stem cell fate within 3-dimensional hydrogels. (nature.com)

Bioelectricity and Bioelectronics to study and influence cell fate. (gla.ac.uk)
Can we harness bioelectricity to influence cell fate? (gla.ac.uk)
External forces play complex roles in cell organization, fate, and homeostasis. (escholarship.org)

Our study highlights critical differences in how muscle stem cells and immune cells respond to mechanical forces in the context of age, and how upregulated inflammation additionally compromises the function of aged stem cells needed for the regeneration of old muscles," said Mooney who also is a core faculty member at the Wyss Institute. (harvard.edu)

Al-positive samples showed a significant increase in both the number of vimentin-positive and nuclear ß-catenin-positive cancer cells compared to Al-negative samples. (bvsalud.org)
My research is focused on nuclear mechanotransduction in keratinocytes. (peerj.com)
Here, we derived relationships between osmolality and nuclear volume, tumor cell density, and Young's modulus, and found the correlations in spheroids resembled single cell relationships previously described in literature. (umd.edu)

Pere Roca-Cusachs obtained his PhD in cellular biophysics in 2007 from the Medical School at the University of Barcelona. (ibecbarcelona.eu)

A key aspect to our physiology is how all the small parts come together, e.g. cytoskeleton, focal adhesions, cell-cell contacts, cell membrane, etc. (washington.edu)
The actin cytoskeleton can be seen in green, coated with active myosin (ppMLC) in red, and the cell-cell junctions (E-cadherin) in blue. (ibecbarcelona.eu)
We then characterize a Holzapfel-Gasser-Ogden type SED for individual VSMCs and find that architecture-dependent properties of the cells can be robustly described using a formulation solely based on the organization of their actin cytoskeleton. (asme.org)

Using the adhesion frequency assay, the force-clamp lifetime assay, the thermal fluctuation assay, and the molecular stiffness assays the Zhu lab has applied these 2D assays to the studies of interactions of the T cell receptors, CD4/8 coreceptors, and co-stimulatory/co-inhibitory receptors with their respective ligands. (meduniwien.ac.at)
Therefore, these substrates represent a unique multipurpose platform for studying receptor/ligand interactions with adhering cells, mechanotransduction, and cell-adhesion-dependent signaling. (cipsm.de)
were used to establish a 3D organotypic in vitro model containing microtumor spheroids, macrophages, neutrophils, fibroblasts and endothelial cells, allowing for the analysis of tumor-stroma interactions in a controlled and modifiable environment. (ilexlife.com)

Generally, cell surface receptors are regarded as the overarching mechanosensors in mechanosensory cells, as they are the first response to changes in the microenvironment [ 10 , 11 ]. (biomedcentral.com)

Christine Petit Ph.D., is a professor in genetics and cellular physiology at College de France. (bna.org.uk)

An engineered biomimetic peptide regulates cell behavior by synergistic integrin and growth factor signaling. (mpg.de)

Breast cancer cells attached to a surface rich in collagen. (ibecbarcelona.eu)
Thus, the researchers observed that the cells seeded on the laminin-rich gel had a very mild mechanical response to the stiffness of the substrate, compared to those seeded on the gels rich in collagen and fibronectin. (ecancer.org)
As a result, the researchers observed that the cells seeded on the laminin-rich gel exhibited a significantly less pronounced mechanical response to the substrate's stiffness when compared to those seeded on gels abundant in collagen and fibronectin. (ecancer.org)

specifically, the role that mechanical forces play in regulating cellular function. (buffalo.edu)
Compliance mismatch is suggested to play an important role in IH because of mechanotransduction. (uwaterloo.ca)
However, the role of LRP6 in the mechanotransduction of mechanically induced PDLSCs remains obscure. (biomedcentral.com)
We also re-introduce the term "mechanotherapy" to distinguish therapeutics (exercise prescription specifically to treat injuries) from the homeostatic role of mechanotransduction. (bmj.com)
Given the close ties between cell mechanics and behaviors, it is of interest to establish if mechanotransduction serves a role in cell signaling dysfunction. (umd.edu)

Crystalline violet staining was used to visualize cell morphological change. (biomedcentral.com)
Intriguingly, LRP6 loss caused cell morphological aberration, F-actin dynamics disruption, YAP nucleoplasmic relocation, and subsequent YAP inactivation. (biomedcentral.com)

This study is considered ground-breaking by demonstrating that tumor cells reactivate the latent EMT morphogenesis program to acquire the ability to invade and metastasize. (aspet.org)

The lab uses single-molecule, whole-cell conventional electrophysiology and optogenetics to better understand gastrointestinal physiology. (mayo.edu)
Through studying the coordinated activity of cells and quantifying their mechanical properties, we can understand normal and diseased physiology at a fundamental level. (washington.edu)

One such input is mechanical force, which activates signalling and regulates cell behaviour in the process of mechanotransduction. (ibecbarcelona.eu)
Following their surprising discovery that mechanotherapy alone actually hinders the normal regeneration process of aged muscles by interacting with the immune system, the team took a deeper look at the muscles' stem cells. (harvard.edu)
Mechanotransduction refers to the process by which the body converts mechanical loading into cellular responses. (bmj.com)

A UB researcher has been awarded a National Heart, Lung and Blood Institute grant to explore how changes in arterial stiffness elicit vascular smooth muscle cell (VSMC) behaviors that contribute to cardiovascular disease. (buffalo.edu)

3-D Life hydrogels and accessories are used in this CloneSeq protocol which combines clonal expansion inside 3D hydrogel spheres and droplet-based RNA sequencing to resolve the limited sensitivity of single-cell approaches. (ilexlife.com)
Figure 3: Controlling cell deployment kinetics from void-forming hydrogels in vitro and in vivo . (nature.com)

Adipose-derived and mesenchymal stem cells exhibited similar properties to each other, but were mechanically distinct from primary cells, particularly when comparing a ratio of elastic to relaxed moduli. (duke.edu)

The cellular microenvironment is highly heterogeneous and dynamic. (ibecbarcelona.eu)
One of our main lines of research is to study how tumours exploit the functions of non-cancer cells in their microenvironment to invade and metastasize. (ibecbarcelona.eu)

In the Cell Biomechanics Lab, we address these questions with new experimental techniques and modeling approaches in order to build up a knowledge base on cell mechanics. (washington.edu)
Standard methods for measuring cellular mechanics report linear moduli that cannot capture large-deformation anisotropic properties, which in a continuum mechanics framework are best described by a strain energy density function (SED). (asme.org)

The phenotype of the cell is supposed to be the translation of the genotype (and of the environment: epigenetics) expressed in a given cell: thus, a liver cell does not look like a pancreas cell at all because it does not express the same genes (yet all present in the genome of all cells). (wikipedia.org)
One of the main challenges with bioprinting cell laden constructs is the identification of an appropriate bioink, as the material not only needs to have the necessary structural and mechanical properties, but should also protect the cells from damage during printing and ultimately provide them with an appropriate environment to direct or control their phenotype and function. (nature.com)

He has made fundamental contributions to our understanding of sound transduction and demonstrated that each hair cell in the cochlea of the inner ear is sensitive to a specific range of sound frequencies. (bna.org.uk)

These cellular responses, in turn, promote structural change. (bmj.com)
The stress in a cell due to extracellular mechanical stimulus is determined by its mechanical properties, and the structural organization of many adherent cells suggests that their properties are anisotropic. (asme.org)

Further examination revealed that PPI hindered the expression of GRP78 protein, resulting in a suppressive effect on SR-HCC cell migration and invasion. (bvsalud.org)

Because there is a great need for improved methods of diagnosis and treatment, Arthur Beyder, M.D., Ph.D., leads the National Institutes of Health-funded Gastrointestinal Mechanotransduction Laboratory at Mayo Clinic. (mayo.edu)
Therefore, the work in Dr. Beyder's laboratory is specifically focused on understanding how mechanical forces impact cellular function both in health and disease. (mayo.edu)

Cells are capable of translating mechanical changes into biological responses. (ecancer.org)

Mechanotransduction, Cellular" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)

As a graduate student at Columbia University and postdoctoral fellow at the University of California, San Diego he focused on the mathematical modeling of cell locomotion and cell adhesion, respectively. (meduniwien.ac.at)
Control of cell adhesion using hydrogel patterning techniques for applications in traction force microscopy. (mpg.de)

Using VSMCs, the study will first explore how vascular ECM stiffness impacts VSMC migration and growth at the single-cell level, and then determine how pathological ECM stiffness drives neointima formation altering the local mechanical environment of VSMCs in vitro. (buffalo.edu)
Also known as taxis, directed cell migration has been commonly associated with chemotaxis, i.e. the ability of a broad variety of cell types to migrate following gradients of chemical factors. (ibecbarcelona.eu)
This new migration mode emerges only in cell collectives and, strikingly, does not require isolated cells to exhibit gradient sensing. (ibecbarcelona.eu)
Our in vitro studies included scratch wound-healing migration assays and transwell assays to examine PPI's effect on HCC cell migration and invasion. (bvsalud.org)
The results of these experiments demonstrated that PPI increased the susceptibility of HCC to sorafenib while inhibiting SR-HCC cell growth, migration, and invasion. (bvsalud.org)

Anatomy12

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes5

Disciplines and Occupations1

Differentiation15

Influencing the process of mechanotransduction1

Pathways5

Extracellular matrix4

Known as mechanotransduction1

Biochemical4

Endothelial cell2

Stimuli4

Cues9

Epithelial12

Pathway1

Tissues11

Proliferation7

Mechanisms5

Bone5

Proteins5

Mechanobiology2

Tissue19

Biology6

Processes6

Physiological process2

Stem cell6

Fate3

Respond to mechanical1

Nuclear3

Biophysics1

Cytoskeleton3

Interactions3

Receptors1

Genetics1

Behavior1

Collagen3

Role5

Morphological2

Tumor cells1

Physiology2

Process3

Vascular smooth1

Hydrogels2

Mechanically1

Microenvironment2

Mechanics2

Phenotype2

Transduction1

Structural2

Protein1

Laboratory2

Biological1

Descriptor1

Adhesion2

Migration5