• NGF seems to enhance survival through the phosphatidylinositol-3 kinase (PI3K) pathway. (umassmed.edu)
  • This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. (wikipedia.org)
  • This protein enhances cell motility, invasion and metastasis of cancer cells. (wikipedia.org)
  • The results obtained indicate that alpha6beta1 is necessary for VEGF expression because the ability of hypoxia to activate HIF-1 and to stimulate VEGF transcription in MDA-MB-435 cells is dependent on alpha6beta1 expression by a mechanism that involves protein kinase C-alpha. (umassmed.edu)
  • ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. (umassmed.edu)
  • Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. (umassmed.edu)
  • An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. (lookformedical.com)
  • GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation. (umassmed.edu)
  • Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase. (nih.gov)
  • However, this mutant was targeted to focal contacts formed by GSK2118436A novel inhibtior other integrins, even when they had not bound ligand. (healthyconnectionsinc.com)
  • We investigated the influence of alpha6beta1 on vascular endothelial growth factor (VEGF) expression because autocrine VEGF is necessary for the survival of serum-deprived cells in hypoxia. (umassmed.edu)
  • To understand the functional interactions between the TrkA and p75 nerve growth factor (NGF) receptors, we stably transfected LAN5 neuroblastoma cells with an expression vector for ET-R, a chimeric receptor with the extracellular domain of the epidermal growth factor receptor (EGFR), and the TrkA transmembrane and intracellular domains. (umassmed.edu)
  • These results demonstrate that TrkA kinase initiates differentiation, and p75 enhances differentiation by rescuing differentiating cells from apoptosis via the PI3K pathway. (umassmed.edu)
  • Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. (wikipedia.org)
  • The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. (wikipedia.org)
  • A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. (lookformedical.com)
  • It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. (wikipedia.org)
  • The alpha6beta1 integrin has been implicated in breast carcinoma progression, but the mechanisms involved remain elusive. (umassmed.edu)
  • MDA-MB-435 cells engineered to be deficient in alpha6beta1 expression form primary tumors that are highly apoptotic and unable to metastasize, although they exhibit no increased apoptosis in vitro under standard culture conditions. (umassmed.edu)
  • ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. (thermofisher.com)
  • Based on the hypothesis that alpha6beta1 is necessary for the survival of these cells in the tumor microenvironment, we report here that hypoxia protects these cells from apoptosis induced by serum deprivation and that hypoxia-mediated protection requires alpha6beta1 expression. (umassmed.edu)
  • 2. EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for phosphatidylinositol 3-kinase and Vav2. (nih.gov)
  • 1. Adhesion, actin cytoskeleton organisation and the spreading of colon adenocarcinoma cells induced by EGF are mediated by alpha2beta1 integrin low clustering through focal adhesion kinase. (nih.gov)
  • 3. Collagen IV regulates Caco-2 migration and ERK activation via alpha1beta1- and alpha2beta1-integrin-dependent Src kinase activation. (nih.gov)
  • 16. Epidermal growth factor increased the expression of alpha2beta1-integrin and modulated integrin-mediated signaling in human cervical adenocarcinoma cells. (nih.gov)
  • Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase. (nih.gov)
  • 12. Reactive oxygen species increased focal adhesion kinase production in pulmonary microvascular endothelial cells. (nih.gov)
  • 10. Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. (nih.gov)
  • 13. A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer. (nih.gov)
  • 4. The integrin, alpha6beta1, is necessary for the matrix-dependent activation of FAK and MAP kinase and the migration of human hepatocarcinoma cells. (nih.gov)
  • 8. Concomitant cell growth and differentiation are dependent on erbB1 and integrin activation in an autonomously surviving colon adenocarcinoma: involvement of autocrine amphiregulin secretion. (nih.gov)
  • 14. Effect of ligand conformation on melanoma cell alpha3beta1 integrin-mediated signal transduction events: implications for a collagen structural modulation mechanism of tumor cell invasion. (nih.gov)
  • 7. Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins. (nih.gov)
  • We investigated the influence of alpha6beta1 on vascular endothelial growth factor (VEGF) expression because autocrine VEGF is necessary for the survival of serum-deprived cells in hypoxia. (nih.gov)
  • 19. Mechanisms of hepatocyte growth factor-mediated vascular smooth muscle cell migration. (nih.gov)
  • The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. (wikipedia.org)
  • 17. Laminin-10 mediates basal and EGF-stimulated motility of human colon carcinoma cells via alpha(3)beta(1) and alpha(6)beta(4) integrins. (nih.gov)
  • 18. Matrix-specific FAK and MAPK reorganization during Caco-2 cell motility. (nih.gov)
  • MDA-MB-435 cells engineered to be deficient in alpha6beta1 expression form primary tumors that are highly apoptotic and unable to metastasize, although they exhibit no increased apoptosis in vitro under standard culture conditions. (nih.gov)
  • It is also known as glycoprotein-27 (GP-27), Red blood cell antigen MER 2 (MER 2), platelet-endothelial tetraspan antigen-3 (PETA-3), Raph blood group antigen (RAPH)/Membrane Glycoprotein SFA-1 (SFA-1) and tetraspanin-24 (TSPAN-24), was located on chromosome 11p15.5 [ 4 , 5 ]. (oncotarget.com)
  • The alpha6beta1 integrin has been implicated in breast carcinoma progression, but the mechanisms involved remain elusive. (nih.gov)
  • Differentiation of Cancer Stem Cells through Nanoparticle Surface Engineering. (umassmed.edu)
  • 15. Role of extracellular matrix-cell interaction and epidermal growth factor (EGF) on EGF-receptors and actin cytoskeleton arrangement in infantile pituitary cells. (nih.gov)
  • av?3 Integrin Mediates Radioresistance of Prostate Cancer Cells through Regulation of Survivin. (umassmed.edu)
  • Based on the hypothesis that alpha6beta1 is necessary for the survival of these cells in the tumor microenvironment, we report here that hypoxia protects these cells from apoptosis induced by serum deprivation and that hypoxia-mediated protection requires alpha6beta1 expression. (nih.gov)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • 5. PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration. (nih.gov)
  • Integrin alpha6beta1 is the qualified online death of the chesapeake a history of the militarys role for Neuropsychological cookies and causes a power in VWF blood, member, and specialized attachment. (texturemonkey.com)
  • Integrin PSI online death of the chesapeake a history of the militarys role in polluting the is clinical paradigm JavaScript coagulation and is a cyclic application for high-level collaboration. (texturemonkey.com)