Cells into th17 th17 cells. Medical search. Frequent questions

There has been much progress in the past year, leading to identification of the molecular mechanisms that drive differentiation of Th17 T cells. (nih.gov)
Furthermore, the role of pathogens and pathogen-derived molecules in influencing effector T-cell polarization needs to be re-evaluated in the light of the differentiation conditions that favor Th17 T-cell responses. (nih.gov)
Here we sought to further understand the effects of idelalisib and duvelisib in vitro, and demonstrate that both idelalisib and duvelisib can inhibit T cell proliferation as well as Th1 and Treg differentiation in vitro, while promoting Th2 and Th17 differentiation. (nature.com)
We further demonstrate directly using intracellular flow cytometry that autoimmune toxicity in patients is associated with higher absolute numbers of CD4 and CD8 T cells with Th17 differentiation in peripheral blood prior to therapy, and that gastrointestinal tissues from patients with active autoimmune complications of PI3Kδ inhibitors show infiltration with Th17 + T cells. (nature.com)
Harrington says her study "found that mitochondrial oxidative phosphorylation is important for the differentiation of pathogenic, autoreactive Th17 effector CD4 T cells and that inhibition of this pathway suppressed Th17 development and Th17 mediated autoimmunity. (uab.edu)
I have always been interested in understanding what regulates the differentiation and specification of distinct subsets of effector CD4 T cells, especially that of the Th17 lineage. (uab.edu)
Honestly, the whole study was based on the unexpected finding that mitochondrial oxidative phosphorylation is essential early for promoting Th17 cell differentiation and suppressing the emergence of regulatory CD4 T (Treg) cells. (uab.edu)
I think when my student repeated the principle finding that inhibition of oxidative phosphorylation blocked Th17 differentiation and promoted the emergence of Foxp3+ Treg cells more than five times. (uab.edu)
Here, we report that anxiolytic FGIN-1-27 inhibits differentiation and pathogenicity of Th17 cells in vitro and in vivo using the experimental autoimmune encephalomyelitis (EAE) model of Th17 cell-driven pathology. (listlabs.com)
The exposure of uterus to seminal fluid induces the CD4 + T cells differentiation into Tregs, leading to uterus environment to be rife with these cells. (biomedcentral.com)
Type I Interferon (IFN) has recently been documented to inhibit Th17 differentiation and IL-17 production. (sjsu.edu)
Type I IFN has been well characterized as an antiviral cytokine, but recent studies linking it to the inhibition of Th17 differentiation have led to investigation of whether type I IFN may be detrimental during bacterial infections. (sjsu.edu)
We used multicolor flow cytometry to characterize the immune cells in our infection model and to study the effects of IFNa on Th17 differentiation. (sjsu.edu)
The recruitment and cytokine secretion of lung pDCs during infection with B. pertussis correlate with the delayed Th17 responses, suggesting a role for pDCs in Th17 differentiation that may account for a longer-lasting disease. (sjsu.edu)
Wu, Victoria, "Plasmacytoid dendritic cell-derived IFNa modulates Th17 differentiation during Bordetella pertussis infection in mice" (2014). (sjsu.edu)
Finally, a number of biologics that target CD4 + T cell differentiation into inflammatory subsets or their byproducts (i.e., cytokines) have shown efficacy in treating patients with IBD ( 5 - 7 ). (frontiersin.org)
Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)
STAT4 also signals activation of the TF T-bet, a lineage-defining factor for Th1 differentiation, which upregulates the IL-12 receptor, IFN-γ expression, and causes further expansion of Th1 cells (Figure 1 ) ( 12 ). (frontiersin.org)
Critical factors in the differentiation of effector Th cells during inflammatory bowel disease (IBD). (frontiersin.org)
CD80/86-CD28 interaction and others), these signals initiate a program of cell division and differentiation. (frontiersin.org)
Interleukin (IL)-12 and IL-23, cytokines induced during early stages of IBD, play important roles in differentiation of interferon (IFN)-γ/tumor necrosis factor (TNF)-producing Th1 cells as well as IL-17-producing Th17 cells. (frontiersin.org)
Despite their importance, the molecular circuits that control the differentiation of naive T cells remain largely unknown. (shaleklab.com)
Here we combine transcriptional profiling at high temporal resolution, novel computational algorithms, and innovative nanowirebased perturbation tools to systematically derive and experimentally validate a model of the dynamic regulatory network that controls the differentiation of mouse T H 17 cells, a proinflammatory T-cell subset that has been implicated in the pathogenesis of multiple autoimmune diseases. (shaleklab.com)
it also highlights novel drug targets for controlling T H 17 cell differentiation. (shaleklab.com)
The inhibitory effect of RGE on Th17 differentiation and osteoclastogenesis observed in mice was also confirmed in the subsequent experiments performed using human peripheral blood mononuclear cells. (hindawi.com)
Therefore, RGE can ameliorate arthritis in mice with CIA by targeting pathogenic Th17 and osteoclast differentiation, suggesting a novel therapy for treatment of RA. (hindawi.com)
Transforming growth factor- (TGF-) β and IL-6 primes initial differentiation and IL-23 promotes functional maturation of Th17 cells [ 7 ]. (hindawi.com)
Genome-wide expression and BCOR chromatin immunoprecipitation studies revealed that BCOR directly represses Lef1, Runx2, and Dusp4, whose products inhibit Th17 differentiation. (umn.edu)
Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased and required during Th17 cell differentiation. (jci.org)
Inhibition of CaMK4 reduced Il17 transcription through decreased activation of the cAMP response element modulator α (CREM-α) and reduced activation of the AKT/mTOR pathway, which is known to enhance Th17 differentiation. (jci.org)
Importantly, silencing CaMK4 in T cells from patients with SLE and healthy individuals inhibited Th17 differentiation through reduction of IL17A and IL17F mRNA. (jci.org)
IL-21 regulates Th17 cell homeostasis enhances the differentiation of storage B cells and antibody-secreting plasma cells and promotes the maintenance of Compact disc8+ T-cell replies. (bio2009.org)
The prototypic KDM6 inhibitor GSK-J4 increases genome-wide levels of the repressive H3K27me3 chromatin mark and leads to suppression of the key transcription factor RORγt during Th17 differentiation. (ox.ac.uk)
These data are consistent with an effect of GSK-J4 on Th17 T cell differentiation pathways directly related to proliferation and include regulation of effector cytokine profiles. (ox.ac.uk)
To assess the potential role of the AhR in PM-mediated activation of DCs, co-stimulation, and cytokine expression, bone marrow (BM)-derived macrophages and DCs from C57BL/6 wildtype or AhR knockout (AhR-/-) mice were treated with PM. Th17 differentiation was assessed via co-cultures of wildtype or AhR-/- BMDCs with autologous naive T cells. (cdc.gov)
In conclusion, PM enhances DC activation that primes naive T cell differentiation towards a Th17-like phenotype in an AhR-dependent manner. (cdc.gov)
Transcription factor Sp2 promotes TGFB-mediated interstitial cell osteogenic differentiation in bicuspid aortic valves through a SMAD-dependent pathway. (nih.gov)

Real-time PCR and ELISA was used to assess the status of Tregs and Th17 related transcription factors and cytokines in mRNA and protein level, respectively. (biomedcentral.com)
Increased Th17 cytokines (IL-21, IL-17 and IL-23) level in these patients has led to neutrophil rich inflammation in uterus and consequent embryo growth inhibition and abortion [ 13 ]. (biomedcentral.com)
Th17 cells gain the pathogenic phenotype by induction with pro-inflammatory cytokines IL-1β, IL-6 and IL-23 during their maturation. (wikipedia.org)
GM-CSF and IL-17 were recognised as the main effector cytokines secreted by Th17 pathogenic cells that promote the development of immunopathology. (wikipedia.org)
The following higher responsiveness to IL-23 stimulation, which is one of the key cytokines involved in Th17 pathogenic switch, and reduced production of regulatory anti-inflammatory IL-10 result in the phenotype change. (wikipedia.org)
The non-immune cells of synovial tissue are expressing the CCR6 ligands upon pro-inflammatory stimulation with IL-17, IL-1β, GM-CSF cytokines secreted by originally recruited immune cells, this is one of the mechanisms of the vicious circle of chronic joint inflammation in rheumatoid arthritis. (wikipedia.org)
Elevated levels of IL-17, IL-23, GM-CSF pro-inflammatory cytokines associated with Th17 pathogenic cells play a key role in demyelination and consequent multiple sclerosis manifestations. (wikipedia.org)
Given the importance of CD4 + Th cells in the disease process, this review will focus on how Th cells differentiate in the inflamed intestinal tract during IBD and how the Th lineage-specific cytokines and transcription factors (TFs) contribute to disease. (frontiersin.org)
Although the exact molecular mechanism of the RA pathogenesis remains elusive, proinflammatory cytokines including tumor necrosis factor- (TNF-) α and interleukin- (IL-) 1 β and autoreactive T cells are known to play central roles in the development and progression of RA [ 1 ]. (hindawi.com)
Isolation of naive T cells from a murine model of lupus revealed increased levels of CaMK4 following stimulation with Th17-inducing cytokines but not following Treg, Th1, or Th2 induction. (jci.org)
Their function depends on T cell receptor (TCR) signaling and cytokines that activate signal transducer and activator of transcription 3 (STAT3). (autophagy.center)
Such increased disease activity in IDO-deficient mice correlated early with increased production of the proinflammatory cytokines interferon-gamma and interleukin-17 by lymph node T cells and later with increased infiltration of Th1 and Th17 cells in the inflamed joints. (ox.ac.uk)
This anastomotic study demonstrated a decrease in IEC TLR4 expression and microbiome diversity which then coincided with increased expansion of regulatory and pro-inflammatory immune cells and cytokines. (biomedcentral.com)
A previous study demonstrated that the activation of CD4+ T cells (Th1) by influenza vaccination leads to the secretion of Th1-type cytokines (e.g., interferon-γ) ( 10 ), which activates macrophage phagocytosis and may subsequently kill intracellular M. tuberculosis . (cdc.gov)
Natural-killer (NK) cells are specialized lymphocytes that have cytotoxic properties in addition to their ability to produce cytokines that assist in the orchestration of adaptive immunity. (medscape.com)
They secrete cytokines to stimulate various effector cells, such as cytotoxic T cells, B cells and macrophages. (biolegend.com)
They can be divided into 2 categories: cytotoxic, which kill infected cells directly, and helper, which make proteins called cytokines that instruct other cells to make certain molecules, move to a specific location or develop in a particular way. (nih.gov)
Depending on which cytokines are present as a T cell matures, it can become one of many types of helper T cell, each of which has a distinct role in immunity. (nih.gov)
Past studies have found that a combination of 3 cytokines-interleukin-1-beta (IL-1-beta), interleukin-6 (IL-6) and transforming growth factor beta (TGF-beta)-drive Th17 cell development. (nih.gov)
To further explore Th17 development, the scientists exposed immature mouse T cells to a variety of cytokines in culture. (nih.gov)
This shows that Th17 cells behave differently depending on which cytokines drove their development, with IL-23 producing Th17 cells that are more likely to cause autoimmune disease. (nih.gov)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)
However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. (cdc.gov)
The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)

IL-17-producing T cells have recently been classified as a new effector T-cell subset, termed Th17, which is distinct from Th1, Th2 and Treg subsets. (nih.gov)
Importantly, blockade of oxidative phosphorylation led to the emergence of Foxp3+ regulatory CD4 T (Treg) cells. (uab.edu)
We never would have predicted that result given the dogma in the literature states Th17 cells require glycolysis and Treg utilize oxidative phosphorylation to function. (uab.edu)
In this specific case, inhibition of mitochondrial oxidative phosphorylation impeded the emergence of autoreactive, pathogenic Th17 cells and instead promoted the generation of Treg that can suppress chronic inflammation and autoimmunity. (uab.edu)
Th17 cells are associated with the induction of numerous diseases, whereas Treg cells are known to inhibit and dampen inflammatory responses. (uab.edu)
Th17 cells are a very heterogenous subset and can switch to display all T helper-like phenotype markers including those typical for Th2, Treg and Tfh. (wikipedia.org)
Our findings provide the first evidence that RGE can regulate Th17 and reciprocally promote Treg cells by inhibiting the phosphorylation of STAT3. (hindawi.com)
be classified into subsets including Th1 Th2 Th17 T follicular helper (Tfh) and regulatory (Treg) cells predicated on their cytokine profile and/or features.8 Pathogenic HIV/SIV infections of human beings and RMs are connected with key perturbations from the relative percentage of the various CD4+ T-cell subsets. (bio2009.org)
Additionally, Treg IL-10 + and IL-22 + cells were increased. (biomedcentral.com)

Th17 cells are critical drivers of autoimmune diseases and immunopathology. (listlabs.com)
Mesenchymal stem cell (MSC)-based therapy for the treatment of autoimmune diseases has demonstrated a particular promise after its successful applications in both animal models and patients. (nature.com)
Our results define the molecular signature of human pro-inflammatory TH17 cells, which can be used to both identify pathogenic TH17 cells and to measure the effect of treatment on TH17 cells in human autoimmune diseases. (usi.ch)
Collectively, our results suggest that CaMK4 inhibition has potential as a therapeutic strategy for Th17-driven autoimmune diseases. (jci.org)
A better understanding of the complex signals between these cells will help researchers design better ways to prevent and treat autoimmune diseases. (nih.gov)

Analysis of gene expression revealed a shift towards Th17 helper T cell driven autoimmunity by HSD. (neurology.org)
Our findings suggest that the small molecule FGIN-1-27 can be re-purposed to relieve autoimmunity by metabolic reprogramming of pathogenic Th17 cells. (listlabs.com)
A group of studies have also indicated a correlation between thyroid autoimmunity and increased Th17 and decreased Tregs cells frequency [ 15 , 16 , 17 ]. (biomedcentral.com)
T helper 17 (Th17) cells are critical for host defense but can also drive autoimmunity . (bvsalud.org)
however, the factors that promote Th17-driven autoimmunity are unclear. (jci.org)
Researchers discovered a new pathway for the development of Th17 cells, a type of helper T cell involved in autoimmunity. (nih.gov)
However, TGF-beta also drives the development of other T cells (regulatory T cells) that dampen the inflammatory response and help prevent autoimmunity. (nih.gov)
The discovery of IL-23 as a driving force in Th17 development points to potential new targets for therapies against autoimmunity. (nih.gov)

Mice lacking PI3Kγ show increased CD8 T cell activation and cytotoxicity due to transcriptional activation of NFκB and inhibition of C/EBPβ in macrophages within the microenvironment [ 9 ]. (nature.com)
Similarly, more Th17 cells accumulated in the gums of mice with periodontitis compared to healthy mice, which served as a control group. (dentistrytoday.com)
To see if the oral microbiome might be the trigger for Th17 cell accumulation, the researchers placed mice on a broad-spectrum antibiotic cocktail. (dentistrytoday.com)
They found that eliminating oral microbes prevented expansion of Th17 cells in the gums of mice with periodontitis while leaving other immune cells unaffected, suggesting that an unhealthy bacterial population triggers Th17 cell accumulation. (dentistrytoday.com)
To see if blocking Th17 cells could reduce periodontal disease, the researchers genetically engineered mice to lack Th17 cells or gave the animals a small-molecule drug that prevents Th17 cell development, finding similar outcomes: reduced bone loss from periodontitis. (dentistrytoday.com)
Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice. (stembook.org)
In vitro, restimulation of MOG primed splenocytes from mice on a HSD led to increased expression of IL-17 and Th17 signature genes. (neurology.org)
In humans, Th17 pathogenic cells are associated with diseases like multiple sclerosis (MS) or rheumatoid arthritis (RA) and in mice with experimental autoimmune encephalomyelitis (EAE). (wikipedia.org)
Mice with RBPJ deficiency have less severe manifestations and faster recovery from experimental autoimmune encephalomyelitis due to fewer Th17 cells developing the pathogenic phenotype. (wikipedia.org)
Lung Th17 cells increased significantly in B. pertussis-infected mice only at 10 days post-infection (dpi) and later. (sjsu.edu)
In addition, blocking IFNa production in mice restored an early increase in Th17 cells during B. pertussis infection. (sjsu.edu)
Methods ID8 tumor cells were injected intraperitoneally into mice. (bmj.com)
Mice were treated with Th17-DC or conventional DC (cDC) vaccine alone or with immune checkpoint blockade (ICB). (bmj.com)
Using T cell-specific loss-of-function experiments, we find that two components of the Polycomb repressive complex 1.1 (PRC1.1), BCL6 corepressor (BCOR) and KDM2B, which helps target the complex to unmethylated CpG DNA islands, are required for optimal Th17 cell formation in mice after Streptococcus pyogenes infection. (umn.edu)
Furthermore, naive T cells from mice lacking CaMK4 did not produce IL-17. (jci.org)
We observed increases in dermal mast cells in imiquimod-induced psoriatic dermatitis in mice accompanied by the expression of epidermal stem cell factor (SCF), a critical mast cell growth factor. (ewha.ac.kr)
A distinct TCRβ hi CD4 + T cells subset after anastomosis was 10-20-fold greater than in control mice. (biomedcentral.com)
They transferred the cells into mice engineered to lack mature T cells of their own. (nih.gov)
Mice that received Th17 cells from IL-23 cultures showed more severe symptoms of EAE. (nih.gov)
IL-17-deficient, but not IFN-γ-deficient, mice failed to clear nasal Bp, indicating a key role of IL-17 + T RM cells in the control of nasal infection. (nih.gov)
Transfer of IL-17 + T RM cells from Bp-infected mice to IL-17-deficient mice resulted in neutrophil recruitment and protection against nasal colonization. (nih.gov)
We observed a significant increase in IFN-γ-producing CD8 + T cells in bronchoalveolar lavage fluid (BALF) of immunocompetent mice that repeatedly aspirated A. fumigatus conidia in contrast to mice challenged with A. versicolor , a species that is not typically associated with invasive, disseminated disease. (cdc.gov)
Airway IFN-γ + CD8 + T-cells were decreased and lung germination was eliminated in mice that aspirated A. fumigatus conidia that were formaldehyde-fixed or heat-inactivated. (cdc.gov)
Furthermore, A. fumigatus particles exhibited greater persistence in the lungs of recipient mice when compared to non-viable A. fumigatus or A. versicolor , and this correlated with increased maintenance of airway memory-phenotype CD8 + T cells. (cdc.gov)

Removing bacteria by tooth-brushing and dental care controls inflammation, but not permanently, suggesting there are other factors at play," said NIDCR clinical investigator and senior author Niki Moutsopoulos, DDS, PhD. "Our results suggest that immune cells known as T helper 17 (Th17) cells are drivers of this process, providing the link between oral bacteria and inflammation. (dentistrytoday.com)
RNA analysis showed the Th17-blocking drug led to reduced expression of genes involved in inflammation, tissue destruction, and bone loss, suggesting that Th17 cells may mediate these processes in periodontitis. (dentistrytoday.com)
Microbiota dysbiosis, disruption of metabolic functions and homeostasis with subsequent high levels of saturated fatty acids (SFA) and cholesterol present in the gastrointestinal tract of obese patients are leading to chronic low-grade inflammation which has an impact on Th17 pathogenic formation. (wikipedia.org)
Many subsets of CD4 + T cells have been identified as players in perpetuating chronic intestinal inflammation. (frontiersin.org)
Inflammatory bowel disease is a complex set of diseases that includes Crohn's disease (CD) and ulcerative colitis (UC), each with multiple bacterial, immune, and non-immune cell types contributing to inflammation. (frontiersin.org)
Although RA was conventionally conceived as Th1-driven inflammatory disease, it is becoming clear that Th17, rather than Th1, is a major pathogenic cell that orchestrates the complex network of the sustained inflammation and disease progression [ 2 - 4 ]. (hindawi.com)
who identify inflammation -associated genes by measuring gene expression in nearly 1,000 individual Th17 cells and show that CD5L affects the expression of pro-inflammatory genes by altering lipid synthesis. (bvsalud.org)
In this study, we determined the effects of keratinocytes on mast cell accumulation during Th17-mediated skin inflammation. (ewha.ac.kr)
Here, we show that abolishing STIM1 and Ca2+ influx in T cells expressing a hyperactive form of STAT3 (STAT3C) attenuates pathogenic Th17 cell function and inflammation associated with STAT3C expression. (autophagy.center)
Our findings establish Ca2+ influx as a critical regulator of mitochondrial function and oxidative stress in pathogenic Th17 cell-mediated multiorgan inflammation. (autophagy.center)
CONCLUSION: Our data indicate that the induction of IDO controls the accumulation of Th1 and Th17 pathogenic T cells at the site of inflammation during collagen-induced arthritis. (ox.ac.uk)
In recent years, several newly identified T helper (TH) cell subsets, such as TH9, TH17, and TH22 cells, and their respective cytokine products, IL-9, IL-17, and IL-22, have been reported to play critical roles in the development of chronic inflammation in the colorectum. (nord.no)
Since chronic inflammation is a potent driving force for the development of human colorectal cancer (CRC), the contributions of TH9/IL-9, TH17/IL-17, and TH22/IL-22 in the pathogenesis of CRC have recently become an increasingly popular area of scientific investigation. (nord.no)
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells. (ox.ac.uk)
We show that IL-1β promotes innate immune pathology in Helicobacter hepaticus-triggered intestinal inflammation by augmenting the recruitment of granulocytes and the accumulation and activation of innate lymphoid cells (ILCs). (ox.ac.uk)
Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
In addition, the effects of macrophages in the occurrence and development of inflammatory bowel disease (IBD), and their role in inducing fibrosis, activating T cells, reducing colitis, and treating intestinal inflammation were also reviewed in this paper. (frontiersin.org)
These helper T cells make a cytokine called IL-17 that causes inflammation. (nih.gov)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)
increased macrophage-derived lining cells are prominent along with vessel inflammation. (msdmanuals.com)
Diabetes Mellitus is a metabolic disease characterized by hyperglycemia due to deficient insulin production type 1 or type 2, that is preceded by systemic inflammation, leading to reduced pancreatic β-cell function, apoptosis and insulin resistence 3 , the latter being more prevalent in adults. (bvsalud.org)

Her research on T-cell receptor signaling, as well as the inhibition of mitochondrial OXPHOS and Th17 pathogenicity, will truly make a difference for many patients. (uab.edu)
On the other hand, regulation of the Th17 immune response by TGFβ1 and IL-10 is known to inhibit Th17 pathogenicity. (wikipedia.org)
RBPJ transcriptional regulator involved in the Notch signalling pathway promotes Th17 pathogenicity by activating the expression of IL23R and repressing the expression of IL-10. (wikipedia.org)
In Th17 cells CD5L is predominantly expressed in non-pathogenic ones, where it functions as a pathogenicity repressor. (wikipedia.org)
A Metabolic Switch for Th17 Pathogenicity. (bvsalud.org)

Human γδ T cells expressing the Vδ3 TCR make up a minor lymphocyte subset in blood but are enriched in liver and in patients with some chronic viral infections and leukemias. (manchester.ac.uk)
Over the last few decades, understanding of how each subset of Th cells plays a role has dramatically increased. (frontiersin.org)
Furthermore, we showed that Th17 cells, a subset of RANKL-expressing CD4 + T cells, could induce rapid N-to-R conversion of mature osteoclasts via cell-cell contact. (jci.org)
A shortage of functional STAT3 blocks the maturation of T cells (specifically a subset known as Th17 cells) and other immune cells. (medlineplus.gov)

Nevertheless, many intriguing questions remain to be answered regarding the regulation of Th17-mediated responses as well as their interactions with the other T-cell subsets. (nih.gov)
Martin Cannon, PhD, discusses the phase 1 investigation of the Th17 dendritic cell vaccine in ovarian cancer, and how it could potentially improve suboptimal responses when treated with immunotherapy alone in this population. (onclive.com)
Martin Cannon, PhD, professor, Department of Microbiology and Immunology, University of Arkansas for Medical Sciences (UAMS) College of Medicine, discusses the phase 1 investigation of the Th17 dendritic cell vaccine in ovarian cancer, and how it could potentially improve suboptimal responses when treated with immunotherapy alone in this population. (onclive.com)
Accordingly, a Th17-stimulating dendritic cell vaccine was developed to potentially improve immune responses and clinical outcomes in this space, Cannon begins. (onclive.com)
A comparison of T-cell frequency before and after vaccination showed that the vaccine successfully stimulated Th1, Th17, and antibody responses to FRα in most patients with ovarian cancer. (onclive.com)
Our findings demonstrate that a high salt diet boosts Th17 responses thus exacerbating autoimmune neuroinflammation. (neurology.org)
Nowatzky J, Manches O, Khan SA, Godefroy E, Bhardwaj N. Modulation of human Th17 cell responses through complement receptor 3 (CD11?b/CD18) ligation on monocyte-derived dendritic cells. (jefferson.edu)
CD4 + T cells are key in mediating the host protective and homeostatic responses. (frontiersin.org)
These cells primarily produce interferon (IFN)-γ and tumor necrosis factor (TNF) that, respectively, activate macrophages and direct cytotoxic CD8 + T cell responses, that in turn promote elimination of intracellular pathogens such as viruses and bacteria ( 8 ). (frontiersin.org)
Recent studies that reconstructed regulatory networks in mammalian cells have focused on short-term responses and relied on perturbation-based approaches that cannot be readily applied to primary T cells. (shaleklab.com)
Conclusions These findings emphasize using biologically relevant immune modifiers, like Th17-DC vaccines, in OC treatment to reshape the tumor microenvironment and enhance clinical responses to ICB therapy. (bmj.com)
Although mast cells are traditionally thought to function as effector cells in allergic responses, they have increasingly been recognized as important regulators of various immune responses. (ewha.ac.kr)
Furthermore, we show that IL-1β promotes Th17 responses from CD4(+) T cells and ILCs in the intestine, and we describe synergistic interactions between IL-1β and IL-23 signals that sustain innate and adaptive inflammatory responses in the gut. (ox.ac.uk)
T helper (Th) cells play important roles in regulating immune responses. (biolegend.com)
The objective of this study was to explore the role of the aryl hydrocarbon receptor (AhR) in ambient particulate matter (PM)-mediated activation of dendritic cells (DCs) and Th17-immune responses in vitro. (cdc.gov)
Therefore, murine airway CD8 + T cell-responses to aspiration of Aspergillus conidia may be mediated in part by the ability of conidia to germinate in the host lung tissue. (cdc.gov)

The immunogenicity and safety of the Th17-stimulating dendritic cell vaccine in patients with stage IIIC-IV ovarian cancer was evaluated in a single-arm, open-label, phase 1 clinical trial (NCT02111941), Cannon details. (onclive.com)
Patients received the dendritic cell vaccine in the maintenance setting following the completion of upfront surgery and chemotherapy, he says. (onclive.com)
To determine if Th17-inducing vaccines are therapeutically effective in OC, we created a murine model of Th17-inducing dendritic cell (DC) (Th17-DC) vaccination generated by stimulating IL-15 while blocking p38 MAPK in bone marrow-derived DCs, followed by antigen pulsing. (bmj.com)

The researchers reasoned that if Th17 cells are as important to periodontitis as the animal studies suggested, a lack of Th17 cells should protect against gum disease. (dentistrytoday.com)
Collectively these data suggest that depletion of IL-21-making Compact disc4+ T cells distinguishes intensifying from non-progressive SIV an infection of RMs and Text message and claim that depletion of Compact disc4+IL-21+ T cells is normally mixed up in preferential lack of Th17 cells that's connected with SIV disease development. (bio2009.org)

Genetic or pharmacologic inhibition of CaMK4 decreased the frequency of IL-17-producing T cells and ameliorated EAE and lupus-like disease in murine models. (jci.org)
STIM1 deletion or inhibition of OXPHOS is associated with a non-pathogenic Th17 gene expression signature and impaired pathogenic Th17 cell function. (autophagy.center)
Single-cell analysis reveals a specific shift from highly inflammatory cell subsets toward a resting state upon demethylase inhibition. (ox.ac.uk)

Vδ3 T cells accounted for ∼0.2% of circulating T cells, included CD4+, CD8+, and CD4-CD8 - subsets, and variably expressed CD56, CD161, HLA-DR, and NKG2D but neither NKG2A nor NKG2C. (manchester.ac.uk)
Th17 pathogenic cells were identified as one of the cross-reactive cell subsets causing inflammatory synovial and cartilage disruption in joints causing rheumatoid arthritis disease. (wikipedia.org)
Th17 pathogenic cells were identified as one of the cross-reactive cell subsets disrupting the protective myelin sheath of neurons causing multiple sclerosis disease. (wikipedia.org)
The T H 17 transcriptional network consists of two self-reinforcing, but mutually antagonistic, modules, with 12 novel regulators, the coupled action of which may be essential for maintaining the balance between T H 17 and other CD4 + T-cell subsets. (shaleklab.com)
We found that MSC-Exo greatly reduced the intensity of ongoing EAU as their parent cells by reducing the infiltration of T cell subsets, and other inflammatory cells, in the eyes. (nature.com)

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism. (ox.ac.uk)

The translational aspect of our studies is pinpointing a new approach to blocking the tissue destruction we see in periodontitis by inhibiting Th17 development. (dentistrytoday.com)

In addition, we exposed dendritic cells and CD4+ T cells to IFNa in vitro, and employed pDC- blocking and depleting antibodies in vivo. (sjsu.edu)
The in vitro effects of MSC-Exo on immune cell migration and responder T cell proliferation were examined by chemotactic assays and lymphocyte proliferation assays, respectively. (nature.com)
Further, keratinocytes promoted mast cell proliferation following stimulation with IL−17 in vitro. (ewha.ac.kr)

T helper (Th) cells are CD4+ effector T cells that play a critical role in immunity by shaping the inflammatory cytokine environment in a variety of physiological and pathological situations. (ox.ac.uk)

A correlation between Th17 cell infiltration and prolonged overall survival in patients with ovarian cancer patients was identified in previous research, prompting interest in harnessing Th17 cells. (onclive.com)

In the immune system, the STAT3 protein regulates genes that are involved in the maturation of immune system cells, especially certain types of T cells . (medlineplus.gov)

Th17 pathogenic refers to a distinct phenotype of Th17 cells which is associated with immunopathology. (wikipedia.org)
Th17 pathogenic cells are known to display pro-inflammatory features like expressing transcription factor T-bet and secreting cytokine IFNγ, resembling Th1-like phenotype. (wikipedia.org)
An important molecule in the Th17 pathogenic phenotype generation is the transcription factor Foxo1. (wikipedia.org)
Loss of CD5L expression drives Th17 cells to the pathogenic phenotype through the subsequent changes in lipid metabolism, and through the alteration of binding of the transcription factor RORγt to its target genes. (wikipedia.org)
The function of important molecules in Th17 pathogenic development like IL-23, CD5L, ACC1 and others are altered in patients with obesity contributing to the phenotype switch. (wikipedia.org)
The root cause of the observed antiinflammatory phenotype in stimulated Th17 cells is reduced expression of key metabolic transcription factors, such as PPRC1. (ox.ac.uk)
PM-treated DCs were essential in endowing T cells with a Th17-phenotype, which was associated with enhanced expression of MHC class II and cyclooxygenase (COX)-2. (cdc.gov)

T-helper 17 (Th17) cells have been implicated in host defense and control of mucosal pathogens, including B. pertussis. (sjsu.edu)
Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity. (jefferson.edu)
CD4 + T helper 17 (Th17) cells protect vertebrate hosts from extracellular pathogens at mucosal surfaces. (umn.edu)
IEC TLR4 activation and signaling is required for mucosal healing, leading to inflammatory factor release that recruits immune cells to limit bacteria invasion. (biomedcentral.com)
Many immune cell types function alongside gut microbiota to promote mucosal healing in the steady state and during injury. (biomedcentral.com)

DC vaccines treated with IL-15 and p38 MAPK inhibitor are more effective than standard DC vaccines at generating antigen-specific Th17 T cells in vivo. (bmj.com)
Furthermore treatment with IL-21 elevated the in vivo degrees of Th17 cells in SIV-infected RMs. (bio2009.org)
Although previous studies have revealed important molecular signals, how the bone resorptive functions of such cells are controlled in vivo remains less well characterized. (jci.org)
Mature osteoclasts expressing TRAP-tdTomato signals ( A ), green fluorescent signals from high H + concentration ( B ), and merged images ( C ). Green fluorescent signals from the H + probes overlapped with static (low CDI, arrowheads) but not moving (high CDI, asterisk) osteoclasts, suggesting that former cells are secreting protons actively and resorbing bone tissues when observed in vivo. (jci.org)

As signal transducer and activator of transcription (STAT) 3 phosphorylation directly regulates retinoic acid receptor-related orphan receptor (ROR) γ t, which is the master molecule of Th17, the Janus kinase (JAK)2-STAT3 pathway initiated by IL-6 is essential in the Th17 development. (hindawi.com)

Prior phenotypic evaluation by CyTOF has identified increases in activated CD8 T cells with activation of Th17 T cells, as well as decreases in Tregs, particularly in patients with toxicity. (nature.com)
These same tissues show depletion of Tregs as compared to CLL patients without toxicity, suggesting that loss of Tregs may be permissive for Th17 activation to lead to autoimmune toxicity. (nature.com)
This study aimed to analyze the association of Tregs and Th17 cells development factors and anti-thyroid peroxidase (anti-TPO) antibodies in RPL patients. (biomedcentral.com)
After blood sampling, the frequency of Th17 and Tregs was evaluated using flow cytometry. (biomedcentral.com)

In recent years, it has become appreciated that distinct metabolic pathways and intermediates can regulate CD4 T cell function, hence we wanted to further investigate how metabolic changes in developing Th17 cells influence cell fate. (uab.edu)
Thus, Vδ3 T cells are glycolipid-reactive T cells with distinct Ag specificities but functional similarities to NKT cells. (manchester.ac.uk)
Here we show that human peripheral blood IFN-γ+IL-17+ (TH1/17) and IFN-γ−IL-17+ (TH17) CD4+ T cells display distinct transcriptional profiles in high-throughput transcription analyses. (usi.ch)
Within this mature population, we observed cells with distinct motility behaviors and function, with the relative proportion of static - bone resorptive (R) to moving - nonresorptive (N) varying in accordance with the pathophysiological conditions of the bone. (jci.org)
These findings shed light on Th17 development, revealing 2 kinds of Th17 cells with distinct functions. (nih.gov)

Harrington's study, "Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells," was recently published in the journal Cell Reports . (uab.edu)
Mechanistically, we showed that oxidative phosphorylation regulates the strength of the T cell receptor signal and that this subsequently controls the induction of the key transcription factor BATF. (uab.edu)
Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis. (ox.ac.uk)
Gut microbiota regulates K/BxN autoimmune arthritis through follicular helper T but not Th17 cells. (msdmanuals.com)

Th17 cells form from naive precursors when signals from the T cell antigen receptor (TCR) and certain cytokine receptors induce the expression of the RORγt transcription factor, which activates a set of Th17-specific genes. (umn.edu)
Assessing 15 representative signature genes in patients with multiple sclerosis, we find that TH1/17 cells have elevated expression of CXCR3 and reduced expression of IFNG, CCL3, CLL4, GZMB, and IL10 compared to healthy controls. (usi.ch)
Deletion of STIM1 in pathogenic Th17 cells reduces the expression of genes required for mitochondrial function and oxidative phosphorylation (OXPHOS) but enhances reactive oxygen species (ROS) production. (autophagy.center)

Modifying the fate of CD4+ T-cells to transition from either inflammatory T cells or regulatory T cells is extremely relevant to inflammatory and autoimmune conditions. (uab.edu)

In mature Th17 cells, GSK-J4 induces an altered transcriptional program with a profound metabolic reprogramming and concomitant suppression of IL-17 cytokine levels and reduced proliferation. (ox.ac.uk)

The migration of Th17 pathogenic cells to the CNS is critical in multiple sclerosis progression and it is mediated by CCR6 chemokine expressed on Th17 pathogenic cell surface. (wikipedia.org)

Th1 cells are important for protecting against infectious pathogens. (frontiersin.org)
These cells play a key role in early resistance to intestinal pathogens. (frontiersin.org)

Remarkably, we found that the effects of FGIN-1-27 were independent of translocator protein (TSPO), the reported target for this small molecule, and instead were driven by a metabolic switch in Th17 cells that led to the induction of the amino acid starvation response and altered cellular fatty acid composition. (listlabs.com)
aPV prevented the natural induction of nasal interleukin-17 (IL-17)-producing and interferon-γ (IFN-γ)-producing CD103 + CD44 + CD69 + CD4 + -resident memory T (T RM ) cells. (nih.gov)
Thus, aPV may have augmented the Bp reservoir by inhibiting natural T RM cell induction and neutrophil recruitment, thereby contributing to the pertussis resurgence. (nih.gov)

ICB had limited efficacy in OC, but Th17-inducing DC vaccination sensitized it to anti-PD-1 ICB, resulting in durable progression-free survival by overcoming IL-10-mediated resistance. (bmj.com)
Th17-inducing DC vaccines block ovarian cancer progression. (bmj.com)
The inclusion of Th17-DC vaccines during treatment with anti-PD-(L)1-based (eg, pembrolizumab, nivolumab) may lead to improved progression-free and overall survival in patients with advanced ovarian cancer. (bmj.com)

Initial results from the study were reported in 2020, and demonstrated that vaccination with Th17-inducing folate-receptor alpha (FRα)-loaded dendritic cells was safe, generated antigen-specific immunity, and was associated with increased remission, Cannon reports. (onclive.com)

The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)
NK cells are specialized effectors of the innate immune system that destroy their targets by antibody-dependent cell-mediated cytotoxicity, have prominent antitumor effects, and are potent killers of virally infected cells. (medscape.com)
Other cellular components of the innate immune system include mononuclear phagocytes, dendritic cells, and NK cells. (medscape.com)
The lamina propria of the small intestine is the main site of the intestinal immune system, which contains a large number of macrophages, CD4 T cells, and dendritic cells. (frontiersin.org)
The immune system employs many different types of cells to regulate disease. (nih.gov)
T cells play a major role in the immune system. (nih.gov)
T cells and other immune system cells help control the body's response to foreign invaders such as bacteria and fungi. (medlineplus.gov)

We analyzed the frequencies, phenotypes, restriction elements, and functions of fresh and expanded peripheral blood Vδ3 T cells. (manchester.ac.uk)

Recently, Th17 was reported to express RANKL itself as well as directly inducing mature osteoclasts via cell-to-cell contact, substantiating its role in inflammatory bone destruction [ 6 ]. (hindawi.com)
These findings provide new insights into the activities of mature osteoclasts in situ and identify actions of RANKL-expressing Th17 cells in inflammatory bone destruction. (jci.org)

Activation of helper T cells also drives their secretion of tumor necrosis factor α, which attracts additional macrophages and lymphocytes and promotes granuloma formation to control the spread of M. tuberculosis ( 3 ). (cdc.gov)
Macrophages, which are functional plasticity cells, have the ability to phagocytize and digest foreign substances and acquire pro-(M1-like) or anti-inflammatory (M2-like) phenotypes according to their microenvironment. (frontiersin.org)
The large number of macrophages in the intestinal tract, play a significant role in maintaining the homeostasis of microorganisms on the surface of the intestinal mucosa and in the continuous renewal of intestinal epithelial cells. (frontiersin.org)
On the other hand, phagosomes are formed when the pathogen is engulfed by macrophages and fuse with lysosomes to release enzymes and toxic substances, resulting in killing or having cytotoxic effects on bacteria and tumor cells. (frontiersin.org)

Finally, the researchers studied a group of 35 patients at the National Institutes of Health Clinical Center with a gene defect causing them to lack Th17 cells. (dentistrytoday.com)
Compared to TH17 cells, TH1/17 cells have gene signatures with marked similarity to mouse pathogenic TH17 cells. (usi.ch)
Gene expression analysis found that Th17 cells from TGF-beta cultures had higher levels of an anti-inflammatory cytokine called IL-10. (nih.gov)
The STAT3 protein is also involved in the formation of cells that build and break down bone tissue, which could help explain why STAT3 gene mutations lead to the skeletal and dental abnormalities characteristic of this condition. (medlineplus.gov)

thus, tissue-specific influences are important for promoting mast cell accumulation and survival in the skin and the gastrointestinal tract. (ewha.ac.kr)
Taken together, our results revealed that the Th17-mediated inflammatory environment promotes mast cell accumulation through keratinocyte-derived SCF. (ewha.ac.kr)
Using a T cell transfer colitis model, we demonstrate a key role for T cell-specific IL-1 receptor (IL-1R) signals in the accumulation and survival of pathogenic CD4(+) T cells in the colon. (ox.ac.uk)

An unhealthy population of microbes in the mouth triggers specialized immune cells that inflame and destroy tissues, leading to the type of bone loss associated with a severe form of gum disease, according to researchers at the National Institute of Dental and Craniofacial Research ( NIDCR ) and the University of Pennsylvania School of Dental Medicine who say their findings have implications for new treatment approaches for the condition. (dentistrytoday.com)
In this particular study, we focused on a mouse model of the human autoimmune disorder Multiple Sclerosis, however, we think that these findings are applicable to other T cell mediated disorders such as Rheumatoid Arthritis and Inflammatory Bowel Disease. (uab.edu)
This review summarizes recent findings and currently available data for understanding the vital role and therapeutic significance of TH9/IL-9, TH17/IL-17, and TH22/IL-22 in the development of colorectal tumorigenesis. (nord.no)

When Mycobacterium tuberculosis infects a host, T-cell-mediated immunity plays a major role in protecting against the development of TB. (cdc.gov)
In this context, M. tuberculosis -induced T-cell-mediated immunity activates macrophage phagocytosis and kills intracellular M. tuberculosis ( 3 ). (cdc.gov)
Previous studies have also demonstrated that the M. bovis bacillus Calmette-Guerin vaccine effectively protects infants from TB through the activation of conventional T-cell immunity ( 4 , 5 ). (cdc.gov)
Innate immunity resides in the skin, mucous membranes, polymorphonuclear (PMN) cells, complement system, and a select group of cells that possess cytotoxic capabilities. (medscape.com)
Secreted aspartyl proteinases (SAPs) are hydrolytic enzymes secreted by Candida that contribute to virulence by degrading host cell mebranes and molecular mediators of host immunity. (medscape.com)

With recent advances in understanding the central role of Th17 in the pathogenesis of RA, novel therapeutics targeting Th17 are being utilized or are still under development. (hindawi.com)

T helper cells recognize antigen presented in the context of major histocompatibility complex II on antigen-presenting cells in a T cell receptor-dependent fashion (not shown). (frontiersin.org)
However, the effects of keratinocytes on mast cells were significantly diminished in the presence of anti−CD117 (stem cell factor receptor) blocking antibodies. (ewha.ac.kr)
Ambient particulate matter activates the aryl hydrocarbon receptor in dendritic cells and enhances Th17 polarization. (cdc.gov)

However, no inhibitory effect of MSC-Exo on IRBP-specific T cell proliferation was observed. (nature.com)

Th17 pathogenic cells express CCR6 chemokine molecule which after binding to its ligand promotes the migration to the joints and synovial tissue. (wikipedia.org)

In these studies, CD4 + T cell-depleting and blocking antibodies caused remission from disease in a number of CD and UC patients examined, suggesting a prominent role of CD4 + T cells in propagating disease ( 1 , 2 ). (frontiersin.org)
Plasma cells produce antibodies (eg, rheumatoid factor [RF], anticyclic citrullinated peptide [anti-CCP] antibody) that contribute to these complexes, but destructive arthritis can occur in their absence. (msdmanuals.com)

Osteoclasts are bone resorbing, multinucleate cells that differentiate from mononuclear macrophage/monocyte-lineage hematopoietic precursor cells. (jci.org)

There is an unmet need to develop therapies targeting pathogenic Th17 cells for the treatment of autoimmune disorders. (listlabs.com)

This study demonstrates that manipulating metabolic pathways in CD4 T cells can alter the functional properties of the cells, which is key for solving chronic inflammatory and autoimmune disorders. (uab.edu)

A significant reduction in STAT3 phosphorylation and a decrease in the number of Th17 cells were observed with RGE treatment. (hindawi.com)
Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. (cdc.gov)
TH17 Cells in STAT3 Related Hyper-IgE Syndrome. (cdc.gov)

Cell-to-cell interactions set off a cascade of events that may result in T- or B-cell activation and, ultimately, host defense. (medscape.com)

These results provide key insights into the mechanisms that underlie development of periodontal disease," said NIDCR director Martha J. Somerman, DDS, PhD. "Importantly, they also offer compelling evidence for therapeutic targeting of specific cells, which might eventually help us provide better treatment and more relief to patients with this common disease. (dentistrytoday.com)

Anatomy10

Organisms4

Diseases2

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes3

Humanities6

Differentiation37

Cytokines25

Treg9

Autoimmune diseases5

Autoimmunity8

Mice24

Inflammation21

Pathogenicity5

Subset4

Responses16

Dendritic cell3

Lack of Th17 cells2

Inhibition3

Subsets5

Human Th17 cell1

Inhibiting Th17 development1

Vitro3

Effector1

Infiltration1

Maturation1

Phenotype7

Mucosal5

Vivo4

Pathway1

Tregs4

Distinct5

Regulates4

Genes3

Regulatory T cel1

Transcriptional1

Pathogenic cell1

Pathogens2

Induction3

Progression3

Antigen-specific1

Immune System8

Peripheral blood1

Inflammatory bone destruction2

Macrophages4

Gene4

Accumulation3

Findings3

Immunity5

Pathogenesis1

Receptor3

Proliferation1

Promotes1

Antibodies2

Mononuclear1

Treatment of autoimmune1

Metabolic1

STAT33

Host defense1

Periodontal disease1