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  • patient's
  • Scientists have long hoped to find a way to reprogram a patient's cells to produce new ones. (redorbit.com)
  • Henry Ford Cancer Institute has treated its first patient with CAR T-cell therapy, an approach that uses engineered cells from a patient's immune system to destroy cancer. (medicalxpress.com)
  • To create specialized cell types for use in cell therapy requires only that we insert the genes (or use non-transgenic approaches) and then test the drug dose and timing required for each cell type and each patient, so it should be relatively scalable at low cost compared to other approaches using each patient's own cells," Waddell says. (eurekalert.org)
  • If human cells can be exploited for therapeutic treatments, Miller says, "complications seen in donor transplantations are avoided as the patient's own cells are being transplanted. (scientificamerican.com)
  • This type of cloning is not intended to produce an offspring, but instead to produce an embryo that has stem cells are made specifically for treating a specific patient's disease. (medindia.net)
  • Harvard Stem Cell Institute
  • Although this is a huge scientific step, Douglas Melton, co-director of the Harvard Stem Cell Institute and a researcher with the Howard Hughes Medical Institute, wrote in the journal Nature that the approach is not ready for people. (redorbit.com)
  • The Melton [ Harvard Stem Cell Institute (HSCI) co-director Doug Melton ] team reports in today's online edition of the journal Nature that, using a technique it is calling 'direct reprogramming,' the team is able to turn mouse exocrine cells, which make up about 95 percent of the pancreas, into precious and rare insulin-producing beta cells. (medgadget.com)
  • fetal
  • The results are a surprise because fetal immune cells haven't had the lifelong "training" that adult immune cells have had, yet they still seem to recognise and destroy abnormal cells. (newscientist.com)
  • About 99 percent of cells found in amniotic fluid are terminally differentiated cells mostly from fetal skin, which are shed into the amniotic fluid as a fetus develops. (scienceblog.com)
  • The discovery led to one even more intriguing - that the memory is fully retrievable: under certain conditions, cells can play the story of their development in reverse to switch on genes that were active in the fetal state. (newswise.com)
  • precursor cells
  • These 'photoreceptor precursor cells' are not undifferentiated stem cells but come from a later stage of cell development when stem cells have already 'committed' to being a particular cell type -- in this case the rod-and-cone photoreceptors the eye uses to sense light. (freerepublic.com)
  • We found that there is something special about these precursor cells that allow the virus to gain entry and dramatically affect their proliferation. (eurekalert.org)
  • neurons
  • But treating brain disorders is no easy task, as brain cells-neurons-have limited ability to regenerate. (medicalxpress.com)
  • But while the main trunk was firmly connected to other target neurons in the cerebellum, stationary as adult axons are generally thought to be, "the side branches swayed like kite tails in the wind," says Linden. (hopkinsmedicine.org)
  • We wondered if Zika would have more of an effect on newly generated neurons than any other parts of the adult brain," says Joseph Gleeson, a physician who studies brain disorders at The Rockefeller University. (eurekalert.org)
  • When cultured, the cellstermed SKPs, for skin-derived precursorsgenerated a variety of different cell types, including neurons, muscle cells and fat cells. (scientificamerican.com)
  • iPSCs
  • The assumption that cells derived from iPSCs are totally immune-tolerant has to be re-evaluated before considering human trials," warned lead investigator Yang Xu, a professor of biology at the University of California at San Diego. (medindia.net)
  • For now, ESCs remain "the gold standard" of versatile stem cells and should not be abandoned, in spite of the controversy surrounding them, in favour of iPSCs, he said. (medindia.net)
  • Xu said he suspected that the problem with iPSCs lay in errors that occur in the DNA code when the cells are reprogrammed. (medindia.net)
  • University of Colorado Cancer Center researcher Chuan-Yuan Li, PhD, and his group have discovered that so-called "grim-reaper" caspase genes are the gatekeepers that can open the door to allow differentiated adult cells to regress to undifferentiated iPSCs. (healthcanal.com)
  • diseases
  • Clinical studies are trying to investigate methodologies to grow large amounts of adult stem cells in cell culture and to engineer them to produce definite cell types so they can be used to treat injuries or diseases. (hubpages.com)
  • With its ability to cure diseases that were previously considered untreatable, stem cell research in India has become quite widespread. (hubpages.com)
  • Amniotic fluid skin cells can be safely obtained from pregnant women undergoing amniocentesis at about 15 weeks of pregnancy as part of a diagnostic workup for chromosome aberrations and other genetic diseases. (scienceblog.com)
  • Developing cell lines from individual amniotic fluid samples can accelerate the development of existing targets for different diseases. (scienceblog.com)
  • We have pursued cell therapy for lung diseases for many years," Waddell says. (eurekalert.org)
  • What diseases and conditions have been treated with adult stem cells? (stemcellresearchfacts.org)
  • Stem Cells are being used today to help people suffering from dozens of diseases and conditions. (stemcellresearchfacts.org)
  • Cultures representing two other hereditary liver diseases, alpha 1-antitrypsin deficiency (a protein-folding disorder that leads to cell death and liver failure) and glycogen storage disease, type 1a (in which a liver enzyme deficiency impairs the body's glucose metabolism), also displayed disorder-specific abnormalities. (scientificamerican.com)
  • This proof-of-principle study shows 'for the first time…that human iPS cells can be used to model a diverse range of inherited diseases in adult cells,' the authors wrote in their paper , published online in The Journal of Clinical Investigation August 25. (scientificamerican.com)
  • In two different attempts to treat degenerative eye diseases with stem cells, three patients have been blinded, while disease progression has been stopped in a separate patient. (bionews.org.uk)
  • The implications of this discovery for how we think about cells' capabilities, and for the future treatment of degenerative and other diseases, are potentially profound. (newswise.com)
  • Because they are responsible for the body's natural ability to fight diseases, heal and recover, or fail and succumb to various maladies, it has become increasingly important to adapt or devise new methods to identify and obtain these cells in quantity and purity for further study. (worldcat.org)
  • nerve cells
  • It could lead to treatments like growing new heart cells after a heart attack or nerve cells to treat disorders like ALS, also known as Lou Gehrig's disease. (redorbit.com)
  • The millions of photoreceptors in the eye act as the retina's 'pixels,' interpreting incoming light and hooking up with nerve cells to transmit that information to the brain. (freerepublic.com)
  • pancreas
  • Islet and whole pancreas transplantations provided the proof-of-concept of glucose homeostasis restoration after replenishment of the deficiency of β cells responsible for the disease. (springer.com)
  • These beta cells, which comrpise [ sic ] about one percent of the pancreas, are the cells that die off in Type I diabetes. (medgadget.com)
  • Eventually we learned that of the 1,100, only about 200 are actually expressed in cells that are involved in forming the pancreas. (medgadget.com)
  • Next,' Melton continued, 'we decided that of the 200, we only cared about the ones that are expressed in the key part of the pancreas where the beta cells are - and that got us down to about 28. (medgadget.com)
  • transplantation
  • A major advantage of this approach is the ability to generate patient-specific iPS cells for transplantation, thereby minimizing the risk of harmful immune reactions. (eurekalert.org)
  • If it's only limited to certain cell types, then maybe other cell types can still be used for transplantation without the worry of being rejected," he said. (medindia.net)
  • The Melbourne success significantly advances international research in limbal stem cell transplantation in the eyes. (freerepublic.com)
  • populations
  • This technology can theoretically be applied to almost any cell type that can be isolated and purified, and isolation of highly purified populations of adult cells from most organs is already possible with existing techniques. (eurekalert.org)
  • The collaborators will next be investigating changes in neural stem cell populations over time in the mouse brain as well as whether the strain of Zika impacts results. (eurekalert.org)
  • Reprogramming
  • The work is "a major leap" in reprogramming cells from one kind to another, said one expert not involved in the research, John Gearhart of the University of Pennsylvania. (redorbit.com)
  • The work brings "more excitement to the idea of using reprogramming as a way to treat diabetes," said researcher Mark Kay of Stanford University, who is studying the approach with liver cells. (redorbit.com)
  • A modified version of iPS methodology, called interrupted reprogramming, allows for a highly controlled, potentially safer, and more cost-effective strategy for generating progenitor-like cells from adult cells. (eurekalert.org)
  • Melton emphasized, however, that direct reprogramming does not in any way eliminate the need for, or value of, work with iPS cells or human embryonic stem cells. (medgadget.com)
  • One problem with using iPS cells therapeutically is that the reprogramming process creates cells prone to forming tumors . (scientificamerican.com)
  • In investigating Jmjd3 and its role in iPSC reprogramming, Wang's team found Jmjd3 has two previously unknown functions - it helps regulate cell growth and cellular aging and Jmjd3 deactivates another nuclear protein, PHF20. (healthcanal.com)
  • donors
  • The embryonic stem cells -- which were created by fusing an adult skin cell with an egg cell that had been stripped of genetic material -- were genetically identical to the donors. (medindia.net)
  • When the team compared three of the disease-specific cultures with the cells generated from the healthy controls, they discovered that the diseased cells had many of the key molecular defects characteristic of the original donors' liver disorder. (scientificamerican.com)
  • Biology
  • Biology textbooks say that once a cell matures to serve a specific role, like, say a red blood cell, it can never go back into a less mature state. (tvnewslies.org)
  • A recent paradigm-shift in cancer biology was the discovery that cancer is a disease resulting from dysregulation of adult stem cells. (conservapedia.com)
  • Critical and cutting edge, Protocols for Adult Stem Cells is an essential guide which provides groundbreaking and novel techniques certain to redefine the field of stem cell biology. (worldcat.org)
  • immune system
  • Certain kinds of these cells may be rejected by the immune system, which would thus doom them as an option for transplant, according to a study published online by the British science journal Nature. (medindia.net)
  • The responders were T cells -- the heavy artillery of the immune system, which are designed to destroy invading microbes. (medindia.net)
  • progenitors
  • Current limitations of these procedures have led to the search for strategies targeting replication of pre-existing β cells or transdifferentiation of progenitors and adult cells. (springer.com)
  • research
  • Research with stem cells, and similar entities called iPS cells that were announced last year, has aimed to achieve this in a two-step process. (redorbit.com)
  • Melton, who began his diabetes research in 1993 when his infant son was diagnosed with the illness, said he's obsessed with trying to find a new treatment or cure for Type 1 diabetes, in which beta cells are destroyed. (redorbit.com)
  • Tsang is optimistic that the research presented by MacLaren's group 'will pave the way for clinical use of stem cell derived photoreceptors. (freerepublic.com)
  • Despite the rapid progress being made with IPS cells, Jaenisch emphasizes that this field is very young, and that it's critical to continue full research on embryonic stem cells as well. (scienceblog.com)
  • Current research with these cells revealed encouraging results in the treatment of a wide variety of medical conditions including stroke and replacement of corneal membrane. (hubpages.com)
  • In fact, according to a recent report published by Forbes, India is one of the frontrunners in stem cell research . (hubpages.com)
  • The guidelines established by the Indian Council for Medical Research (ICMR) and Department of Biotechnology in 2007 are quite liberal in nature and have in turn facilitated development of stem cell research in India. (hubpages.com)
  • There remains today a need in stem cell research for an easily reprogrammable cell type," said the study's lead author, Dr. Katalin Polgar, Assistant Professor of Medicine, Cardiology and Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine. (scienceblog.com)
  • Has anyone actually benefited from from adult stem cell research? (stemcellresearchfacts.org)
  • Years of research on monkey cells using the same technique have not successfully produced any monkey clones. (medindia.net)
  • One problem in liver research is that no one is able to grow liver cells in the lab,' says the study's lead author, Sheikh Tamir Rashid. (scientificamerican.com)
  • Cardinal Martino said the adult stem-cell research project enjoys Vatican support due to its respect for the life of the embryo. (thenewamerican.com)
  • Cell Stem Cell ( @CellStemCell ), published by Cell Press, is a monthly journal that publishes research reports describing novel results of unusual significance in all areas of stem cell research. (eurekalert.org)
  • Each issue also contains a wide variety of review and analysis articles covering topics relevant to stem cell research ranging from basic biological advances to ethical, policy, and funding issues. (eurekalert.org)
  • A paper in the journal Stem Cell Reports has reignited debate among a section of the stem cell research community. (bionews.org.uk)
  • Stem cell research isn't a topic you'd expect to see in a comic book, particularly when the aim is to give a realistic insight into the subject, avoiding hype and sensationalism. (bionews.org.uk)
  • MELBOURNE, April 18, 2007 (LifeSiteNews.com) - A man's vision has been restored by a corneal patch grown from adult stem cells by a team at the University of Melbourne's Centre for Eye Research Australia (CERA) and the Bernard O'Brien Institute of Microsurgery (BOBIM). (freerepublic.com)
  • Beneficiaries of any research derived from embryonic stem cells actually have more in common, morally, with Bram Stoker s Dracula, who requires the blood of unwilling victims to survive. (freerepublic.com)
  • We believe our discovery is important as we have identified an exciting new stem cell from a noncontroversial source that holds considerable promise for scientific and therapeutic research," says co-author Freda Miller. (scientificamerican.com)
  • It also holds promise for cancer research, particularly on the ability of cancer cells to activate long-unused genes to help them spread throughout the body. (newswise.com)
  • Such cells have traditionally been thought to be limited in potential--with, for example, gut stem cells giving rise to gut cells and brain stem cells producing only brain cells--although recent research has been challenging that thinking. (medindia.net)
  • brain
  • Light stimuli also began to spark new activity in brain cells associated with vision. (freerepublic.com)
  • Activity of four transcription factors distinguishes a small proportion of glioblastoma stem cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor. (medindia.net)
  • Five Parkinson's disease patients in another study received brain injections of a natural body chemical known as glial cell-line derived neurotrophic factor (GDNF). (washingtontimes.com)
  • Right: Exemplar time-lapse images of axon in the intact brain of a living, anesthetized adult mouse. (hopkinsmedicine.org)
  • Increased incidence of Guillain-Barré Syndrome has been associated with the virus, raising questions about whether Zika has a negative impact on the adult brain. (eurekalert.org)
  • skin
  • The Merriam-Webster's Dictionary defines stem cells as "a simple cell in the body that is able to develop into any one of various kinds of cells (such as blood cells, skin cells, etc. (hubpages.com)
  • We induced amniotic fluid skin cells to return from their final differentiated stage back to an undifferentiated stem cell stage from where they can develop into any cell type of the body," said Dr. Polgar. (scienceblog.com)
  • Additionally, stem cells reprogrammed from amniotic fluid skin cells could be used for drug discovery in disease models," added Dr. Polgar. (scienceblog.com)
  • A stem cell is essentially a "blank" cell, capable of becoming another more differentiated cell type in the body, such as a skin cell, a muscle cell, or a nerve cell. (stemcellresearchfacts.org)
  • They reprogrammed the skin cells, rejuvenating them into an embryolike state (using the four-gene approach described in 2007). (scientificamerican.com)
  • They made their discovery when they introduced the caspase inhibitors into skin cells, which almost completely shut down the induction of iPS cells. (healthcanal.com)