Cells including adipocyte precursor cells. Medical search. Frequent questions

2.8 cells recognize antigens, some of which are restricted to osteoblasts and chondrocytes. (docksci.com)
This study has also identified cell surface antigens of ROS 17/2.8 cells that are not expressed by osteoblasts in vivo. (docksci.com)
Our findings demonstrate for the first time that molecular changes in osteoblasts influence the susceptibility to swelling by altering evasion of innate immune cells from your bone Lesopitron dihydrochloride marrow space. (informationalwebs.com)
As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs) have emerged as a versatile and frequently utilized cell source in the fields of … MSC have been shown to differ-entiate in vitro into adipocytes, chon-drocytes, osteoblasts, myocytes, and ß-pancreatic islets cells. (tomeipowered.com)
The term 'mesenchymal stem cells' (MSCs) is most commonly used to describe multipotent self-renewing cells that can be differentiated in vitro to generate adipocytes, chondrocytes, and osteoblasts. (tomeipowered.com)
Concomitantly, the ability of MSCs to differentiate and give rise to multiple cell types such as adipocytes, chondrocytes, and osteoblasts … These transplants vastly increase the bodyâ s natural healing abilities and have potent anti-inflammatory and immunosuppressive responses.Â. (tomeipowered.com)
osteoblasts, chondrocytes, endothelial-cells and also non-mesoderm-type lineages e.g. (tomeipowered.com)
Mitochondria regulate cell proliferation and differentiation, particularly in osteoblasts and adipocytes [12C14]. (healthyconnectionsinc.com)
HSCs are able of distinguishing into the several myeloid and lymphoid lineages while MSCs maturate to the several mesodermal lineages including adipocytes, osteoblasts and fibroblasts. (cancer8.info)
MSCs have a lower ability to differentiate into osteoblasts but a higher ability to differentiate into adipocytes, which could be linked to myeloid malignancies ( Woods and Guezguez, 2021 ). (techscience.com)
Adipose tissue-derived stem cells (ADSCs) have been characterized as having the ability to self-renew and differentiate into different connective tissue cells, including osteoblasts, adipocytes, chondrocytes and myocytes, under specific inductive stimuli ( 4 ). (spandidos-publications.com)
Osteoblasts were obtained from human bone marrow cells even in the absence of growth factors and showed a typical morphology. (bvsalud.org)

Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
Therefore, growth of adipose tissue includes the hypertrophy of already existing adipocytes and the proliferation and differentiation of new ones from MSCs. (biomedcentral.com)
In addition, various adipokines secreted by adipocytes regulate the proliferation and differentiation of T cells. (frontiersin.org)
Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. (biomedcentral.com)
Understanding the regulation of the pathways that lead to proliferation and differentiation of white and brown pre-adipocytes could be crucial for revealing the underlying mechanisms of obesity. (biomedcentral.com)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)

We have generated a panel of 15 MAbs to ROS 17/2.8 cells, 5 of which recognize antigens restricted to normal rat OBs and chondrocytes in vivo. (docksci.com)
Mesenchymal stem cells (MSCs) show trilineage differentiation because these cells differentiate into osteocytes, chondrocytes and adipocytes. (nature.com)

In studying adipogenesis, precursor markers, including Pref-1 and PDGFRα, are used to isolate precursors from stromal vascular fractions of WAT, but the relation among the markers is not known. (nih.gov)
Adipogenesis has been described as a two-step developmental process consisting on the commitment of undifferentiated MSCs into preadipocytes and the further development of these cells into fully functional mature adipocytes [ 4 ]. (biomedcentral.com)
Adipogenesis has been extensively studied in mammals [ 7 ] and several cell and animal models have been successfully used to describe the chronology of the molecular events governing this process. (biomedcentral.com)
Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities. (springer.com)
Several models exist to study adipogenesis in vitro , of which the cell line 3T3-L1 is the most well known, albeit not the most physiologically appropriate. (biomedcentral.com)
We found 65 miRNAs regulated during in vitro adipogenesis in primary adipocytes. (biomedcentral.com)
When comparing primary adipocyte profiles, with those of cell lines reported in the literature, we found a high degree of difference in 'adipogenesis' regulated miRNAs suggesting that the model systems may not be accurately representing adipogenesis. (biomedcentral.com)
In conclusion, we provide a preliminary analysis of miRNAs associated with primary cell in vitro adipogenesis and demonstrate that the inflammation-associated miRNA, mir-21 is up-regulated in subcutaneous adipose tissue in human obesity. (biomedcentral.com)
It has been suggested that adipogenesis is regulated by PPARβ/δ followed by PPARγ and C/EBPα promoting differentiation into mature adipocytes [ 12 ]. (biomedcentral.com)
Adipogenesis, the process of fat cell formation, is tightly regulated by epigenetic mechanisms. (alliedacademies.org)
In the context of adipogenesis, DNA methylation patterns are dynamically regulated, leading to changes in gene expression that impact fat cell development[ 1 ]. (alliedacademies.org)
For instance, hypermethylation of the promoter region of the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) gene, a master regulator of adipogenesis, can suppress its expression, impairing fat cell formation. (alliedacademies.org)
On the other hand, hypomethylation of genes associated with lipid storage and adipocyte development can promote adipogenesis. (alliedacademies.org)

In addition, its action on the 3T3-F442A cell line was tested in terms of regulation of proliferation capacity and differentiation into mature adipocytes as well as its effects on mature adipocytes. (nature.com)

Single-cell sequencing reveals that these de-differentiated adipocytes lose their original identities and transform into multiple cell types, including myofibroblast- and macrophage-like cells, with their characteristic features involved in immune response, inflammation, and extracellular matrix remodeling. (usda.gov)
Several research have got recommended that differentiation of adipocyte precursors into macrophage-like cells (6 also,13) may appear, although this continues to be controversial. (bioinbrief.com)

Collectively, the metabolic interplay between tumor cells and adipocytes induces adipocyte mesenchymal transition and contributes to reconfigure the stroma into a more tumor-friendly microenvironment. (usda.gov)
Conversely, ectopic expression of PRDM16 in myoblasts induces their differentiation into brown fat cells. (bioseek.eu)

We have previously shown that fish primary preadipocytes differentiate into mature adipocytes in vitro and that these cells represent a very helpful model system to study adipose tissue development in fish [ 5 , 6 ]. (biomedcentral.com)
In vivo , the identification of macrophage phenotype is complicated since macrophages are obviously exposed to a microenvironment that is more complex respect to cell culture conditions, and they display characteristics that do not conform to the in vitro defined phenotypic categories. (hindawi.com)
In vitro analysis with 3T3-F442A cells revealed anti-proliferative and anti-differentiation effects of OBEX. (nature.com)
Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
In vitro, these MAbs recognize cell surface antigens present on two additional cell lines, ROS 24/1 and Rat 2 cells, and on the adherent cell population cultured from rat long bone marrow. (docksci.com)
Another four MAbs (UBIM 10, 11, 14, and 22) bind to a variety of cells and tissues both in vitro and in vivo. (docksci.com)
Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)

Adipose-derived mesenchymal stem cells (ASCs) are a promising option for the treatment of obesity and its metabolic co-morbidities. (bvsalud.org)
We found that both ASC therapies mitigated the metabolic abnormalities of obesity to a similar extent, including reducing weight gain and improving glucose tolerance. (bvsalud.org)
The epidemic of obesity, closely associated with increases in diabetes, hypertension, hyperlipidemia, cancer and other disorders, has propelled a major interest in adipose cells and tissues. (bioseek.eu)
Obesity is a metabolic disorder characterized by a chronic low-grade inflammatory state, as reflected in increased levels of circulating inflammatory markers, including pro-inflammatory cytokines and the acute phase protein C-reactive protein (CRP) ( 1 - 4 ). (frontiersin.org)
Systemic inflammation in obesity originates primarily from the adipose tissue, in which adipocytes and infiltrated immune cells accumulate and secrete inflammatory factors ( 2 - 5 ). (frontiersin.org)
A recent example of the importance of adipocyte function to have profound systemic effects is provided by the report that mice specifically lacking insulin signaling in adipocytes (FIRKO mouse) are not only lean, leptin sensitive, and obesity resistant ( 1 ), but live almost 20% longer than wild-type control animals ( 2 ). (diabetesjournals.org)
OBJECTIVE In severely obese individuals and patients with diabetes, accumulation and activation of macrophages in adipose tissue has been implicated in the development of obesity-associated complications, including insulin resistance. (bioinbrief.com)
This inflammatory response continues to be implicated in the pathogenesis of obesity-associated problems, including atherosclerosis (2), non-alcoholic fatty liver organ disease T (3), and insulin level of resistance (4). (bioinbrief.com)
Adipose tissues is an initial site of obesity-induced irritation and a complicated organ formulated with adipocytes aswell as connective tissues matrix, nerve tissues, stromal vascular cells, and immune system cells. (bioinbrief.com)
A cardinal feature of obesity-induced irritation in adipose tissues may be the recruitment of immune system cells, macrophages (5 specifically,6). (bioinbrief.com)
Mechanistic studies developed in cell culture and animal models show that β-carotene, the main precursor of vitamin A and retinoic acid, decreases obesity by promoting fatty acid oxidation in adipocytes and other tissues. (goombara.com)
There is a considerable body of knowledge, supported by rigorous experimental data, that natural polyphenols, including curcumin, can be an effective and safer alternative for managing obesity. (mdpi.com)
In the USA, obesity has recent- obesity is associated with progres- aberrations of cancer cells, summa- ly surpassed tobacco use as the sion but not incidence [9]. (who.int)

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated, surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. (peprotech.com)
At first, the mesenchymal stem cell was thought to be the primary component of this undifferentiated cell type, however it is now evident that within the adipose extracellular matrix are also adipocytic precursors (known as progenitor cells) adherent to adipocytes, and in close approximation to a variety of additional undifferentiated multipotent and pluripotent cells, including pericytes and endothelial cells, all thought to play important roles in mesenchymal-stromal derived tissue regeneration. (journalofprolotherapy.com)
we evaluate the different types of come cells and progenitor cells that are potential candidates for restorative strategies in perinatal mind accidental Rabbit Polyclonal to DRP1 injuries, and sum it up recent preclinical and medical studies. (cancer8.info)
Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)

Alternatively, if immature precursors of BAT are already present in WAT, these can differentiate into mature brown adipocytes. (news-medical.net)

We show the requirement of Sox9 for the maintenance of Pref-1 + proliferative, early precursors. (nih.gov)
GRPs are early precursors within the oligodendrocytic and astrocytic cell lineages and are described by their reflection of A2C5 [46, 47]. (cancer8.info)

Brown adipocytes are smaller than white adipocytes and contain multitudes of small (multilocular) lipid droplets. (news-medical.net)
They also contain fewer mitochondria than brown adipocytes. (news-medical.net)
Brown adipocytes contain a large number of mitochondria in their cytoplasm, which express Uncoupling Protein 1 (UCP1), a protein that stimulates the process of non-shivering thermogenesis. (news-medical.net)
These induced brown adipocytes in WAT are referred to as Brown in white (brite) or 'beige' adipocytes and differ from conventional BAT in infants. (news-medical.net)
In addition to the classic brown adipocytes, a different type of brown fat cells seems to exist in tissues where WAT predominates. (biomedcentral.com)

Oxandrolone Information Oxandrolone is a naturally occurring steroid hormone found naturally in human adipocytes in the adrenal glands, steroids for sale perth. (paradiseessentials2020.com)

Cells Tissues Organs (Print). (wikipedia.org)
Virtually absent from normal pediatric and adult tissues, with the exception of low-level expression in a subset of immature b cell precursors known as hematogones and adipocytes, ROR1 is notably overexpressed, and considered a survival factor, in a number of B lymphoid and epithelial malignancies: including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, lung adenocarcinoma. (peprotech.com)
This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
Adipose tissues contain two distinct types of fat cells, white and brown. (bioseek.eu)
Studies of the interactions of this panel of MAbs with osteogenic tissues and cell lines may have an important impact on the understanding of osteoblast physiology. (docksci.com)
Recognition of the vast number of undifferentiated cells associated with the stromal vascular fraction has resulted in extensive research demonstrating the heterogeneity of such cells, and their ability to participate in production of all mesodermal-derived tissues. (journalofprolotherapy.com)
MSCs make the different specialized cells found in the skeletal tissues. (tomeipowered.com)
However the adipocyte may be the determining cell of adipose tissues and does donate to the creation of inflammatory substances (7), it would appear that macrophages donate to the inflammatory indicators that are induced by weight problems (5 significantly,8C11). (bioinbrief.com)
Among the inflammatory elements whose expression is certainly upregulated in adipose tissues using the starting point of weight problems, some have already been implicated in recruitment of macrophages to adipose tissues, including chemokines, BIX 02189 ic50 while some seem to be derived mainly from adipose tissues macrophages (ATMs). (bioinbrief.com)
Research in rodents suggest that ATMs are bone tissue marrowCderived cells recruited to adipose tissues during intervals of positive energy stability and raising adiposity (5). (bioinbrief.com)
In addition to their capability to integrate into web host tissues, OECs exhibit trophic elements including NGF also, GDNF and BDNF along with their cognate receptors [53]. (cancer8.info)
Stem cells have potential as a source of cells and tissues for research and treatment of disease. (tocris.com)
Although less fat stor- adqcKO pose lipid storage in adipocyte-speci﫿c Senp2 knockout mice fed age was shown in Senp2 adipose tissues, the increased with high-fat diets (HFD). (deepdyve.com)
Therefore, adipocyte-speci﫿c remain in adipose tissues. (deepdyve.com)
When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)

Type 1 diabetes mellitus is a metabolic disease resulting from the destruction of insulinproducing β cells in the pancreas, that leads to hyperglycemia [1,2,20]. (researchgate.net)
These transformed cells possess different metabolic states, act differently, and help the cancer cells grow. (usda.gov)
Adipocytes can regulate adaptive immunity, which is involved with various metabolic diseases. (frontiersin.org)
Since there have been many reports on the regulation of metabolic diseases through adaptive immunity ( 9 - 11 ), we focus on how adipocytes regulate adaptive immunity in this review. (frontiersin.org)
It's been hypothesized a metabolic indication(s) or tension(ha sido) network marketing leads to activation of endothelial cells, creation of chemoattractants with following transendothelial migration of monocytes (12), monocyte differentiation into mature macrophages, and macrophage activation ultimately. (bioinbrief.com)
However, in conditions such as insulin resistance or metabolic syndrome, the cells become less responsive to the effects of insulin, leading to elevated blood sugar levels and increased fat storage. (wellnesscenteroflakewoodranch.com)
supports the concept that metabolic reprogramming, inflammation, and genome instability (including epige- netic changes) underlie many of the other hal marks and foster multiple hallmark functions. (who.int)

FOXC1 silencing inhibits the epithelial‑to‑mesenchymal transition of glioma cells: Involvement of β‑catenin signaling. (cancerindex.org)

INTRODUCTION HE OSTEOBLAST (OB) is a key cell in bone formation, synthesizing and secreting the organic matrix of bone, and is involved in the regulation of matrix mineralization. (docksci.com)
This review will address the biology, actions, and regulation of three adipocyte hormones-leptin, acylation stimulating protein (ASP), and adiponectin-with an emphasis on the most recent literature. (diabetesjournals.org)
Work in our laboratory has primarily focused on the biology and regulation of three key adipocyte hormones: leptin, acylation-stimulating protein, and adiponectin. (diabetesjournals.org)
Because the biology of leptin, including its role in energy balance and the regulation of its production, has been reviewed in detail ( 3 , 4 ), this section will primarily concentrate on more recent findings not covered in previous reviews. (diabetesjournals.org)
C/EBPbeta was highly expressed both in SC and in OM preadipocytes, but was not regulated by F. Our results provide insight into the genes involved in the regulation of adipocyte differentiation by cortisol, highlighting the depot specifically in human adipose tissue. (ox.ac.uk)
Epigenetic mechanisms include DNA methylation, histone modifications, and non-coding RNA molecules, all of which contribute to the regulation of gene expression. (alliedacademies.org)
Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. (tocris.com)

The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
Results: Bone marrow cells were adherent since the first day of culture and were positive for osteonectin. (bvsalud.org)
Conclusions: This study showed that an osteoblastic cell lineage may be obtained from human bone marrow derived from adherent cells, and that the presence of the rhBMP-4 seems to have an effect during the first stages of differentiation only. (bvsalud.org)

METHODS: We studied the phenotype of wild-type and Sucnr1-/- mice fed a choline-deficient high-fat diet to induce non-alcoholic steatohepatitis (NASH), and explored the function of SUCNR1 in murine primary hepatocytes and human HepG2 cells treated with palmitic acid. (bvsalud.org)
CONCLUSIONS: We identify hepatocytes as target cells of extracellular succinate during NAFLD progression and uncover a hitherto unknown function for SUCNR1 as a regulator of hepatocyte glucose and lipid metabolism. (bvsalud.org)
As in hepatocytes and absorptive cells of the intestine, this spatial relationship of ER and plasmalemma suggests a role for rosettes in the uptake of exogenous lipid precursors. (silverchair.com)

Here, we report that adipocytes from tumor-invasive mammary fat undergo de-differentiation to fibroblast-like precursor cells during tumor progression and integrate into the tumor microenvironment. (usda.gov)
The de-differentiated cells are metabolically distinct from tumor-associated fibroblasts but exhibit comparable effects on tumor cell proliferation. (usda.gov)
In contrast, promoting lipid-storage capacity in adipocytes through MitoNEET overexpression curbs tumor growth despite greater adiposity. (usda.gov)
A cell line derived from cultured tumor cells. (lookformedical.com)
The inherent tumor-tropic property of MSCs can be used to target cancer cells. (tomeipowered.com)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)

But, when we change the metabolism of these cells, we can slow down the growth of the breast cancer cells in our animal study. (usda.gov)
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. (lookformedical.com)
It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION . (lookformedical.com)
Moreover, white adipocytes have a low oxidative rate, which is the rate of macronutrients (protein, fat, and carbohydrate) metabolism. (news-medical.net)
These alterations can affect the metabolism of tryptophan (TRP), an essential amino acid and precursor of serotonin (5-HT), kynurenine (KYN), and indoles. (frontiersin.org)
A growing body of evidence indicates that inflammation is associated with alterations in the metabolism of tryptophan (TRP) ( 12 , 13 ), an essential amino acid and biochemical precursor of serotonin (5-HT), kynurenine (KYN) and indoles ( 14 ). (frontiersin.org)
Several unexpected findings in genetically altered mice have prompted research into the direction of intermediate metabolism of skeletal cells. (mdpi.com)
Leptin production is primarily regulated by insulin-induced changes of adipocyte metabolism. (diabetesjournals.org)
Adipocytes produce a number of hormones that have wide-ranging effects on energy intake, energy expenditure, and carbohydrate and lipid metabolism, including nutrient partitioning and fuel selection. (diabetesjournals.org)
Among the most interesting were transcription factors, markers of adipocyte differentiation and glucose metabolism, cell adhesion and growth arrest protein factors involved in G-coupled and Wnt signalling. (ox.ac.uk)
The differentiation of preadipocytes into mature adipocytes involves a series of epigenetic changes that control the expression of genes responsible for fat storage and metabolism. (alliedacademies.org)
Studies have shown that changes in DNA methylation patterns can affect the expression of genes involved in adipocyte differentiation and lipid metabolism. (alliedacademies.org)
In adipocyte Senp2-de﫿ciency mice, accumulation of the SUMOylated Setdb1 suppressed the expression of Pparg and Cebpa genes as well as lipid metabolism-related target genes, which would decrease the ability of lipid storage in adipocytes. (deepdyve.com)

In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
Most clinical trials which utilize ADSCs for OA treatment have been based on the autologous cells from the stromal vascular fraction, as have most of the in vivo studies ( 6 , 7 ). (spandidos-publications.com)

Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage. (bioseek.eu)
ER cisternae are also situated very close to "rosettes,"plasmalemmal specializations found in mature adipocytes in vivo. (silverchair.com)
In the suitable moderate, these cells start showing the early oligodendrocytic family tree indicators PDGFR and NG2 and possess lately been proven to become mature oligodendrocytes in vivo [48]. (cancer8.info)

Methods 3T3‐L1 preadipocytes were differentiated by using a mixture of adipogenic inducers, including a suboptimal concentration of insulin. (researchgate.net)
The morphological differentiation of 3T3-L1 preadipocytes includes the loss of "stress fibers" and the appearance of microfilament like structures that encase, in a complex manner, the cytosolic lipid spheres that appear during differentiation. (silverchair.com)
The aim of this study was to identify depot-specific glucocorticoid-target genes in adipocyte precursor cells (preadipocytes) using Affymetrix microarray technique. (ox.ac.uk)
C/EBPalpha was expressed in SC preadipocytes and upregulated by F, but was below the detection level in OM cells. (ox.ac.uk)

Alternatively activated M2 macrophages comprise cells exposed to low concentrations of M-CSF in the presence of IL-4, IL-13, or IL-10. (hindawi.com)
In rodents, genetic manipulation of the activation of myeloid cells, including macrophages, alters insulin sensitivity (20C22). (bioinbrief.com)

This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
Experiments performed in mice and humans have revealed that subcutaneous WAT can acquire BAT characteristics which include fatty acid and glucose utilization. (news-medical.net)
It allows cells in the body to take up glucose from the bloodstream and use it for energy or store it for later use. (wellnesscenteroflakewoodranch.com)
By enhancing insulin sensitivity, berberine facilitates the uptake of glucose by cells, preventing its accumulation in the bloodstream. (wellnesscenteroflakewoodranch.com)
Berberine also promotes the utilization of glucose by cells for energy production. (wellnesscenteroflakewoodranch.com)

The blood vessels constitute a barrier, inhibiting immature blood cells from leaving the bone marrow. (medscape.com)

They can differentiate into cells of the mesodermal lineage, such as adipocytes, and osteocytes. (tocris.com)

FLT3 ligand regulates thymic precursor cells and hematopoietic stem cells through interactions with CXCR4 and the marrow niche. (ctsicn.org)
Monoclonal antibodies (MAbs) have been used successfully to characterize the cell surface of T other cell types, such as o s t e o ~ l a s t s (and ~ ~ ~lymphoid ) and myeloid cells, and to study the lineage of cells of the hematopoietic system. (docksci.com)
The most generally utilized and most likely greatest defined of the SSCs are hematopoietic (HSC) and mesenchymal (MSC) control cells. (cancer8.info)

Gene KOs of critical Atglistatin factors (KO mouse iPSCs (miPSCs), representing na?ve precursors to multiple lineages present in Wolfram syndrome. (healthyconnectionsinc.com)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)

These hormones are referred to as adipokines and include the satiety and hunger hormones, ghrelin and leptin. (news-medical.net)
In addition to their main functions, adipocytes have endocrine functions and can secrete a variety of adipokines such as leptin, adiponectin, and resistin ( 2 - 4 ). (frontiersin.org)
Simultaneously, adipocytes secrete various cytokines including leptin, resistin, TNF-α and IL-6 to regulate the differentiation and function of T and B lymphocytes. (frontiersin.org)

In differentiating 3T3-L1 cells, lipid spheres, the endoplasmic reticulum (ER), microperoxisomes, and mitochondria form "constellations" that may reflect the interplay of lipid metabolizing enzymes in these organelles. (silverchair.com)
The intracellular distribution of mitochondria has been associated with the degree of stemness in adult monkey stromal stem cells [15], suggesting that their differential distribution affects the maturation of developing embryonic stem cells [16]. (healthyconnectionsinc.com)
Thus, citric acid cycle intermedi- ates are not used for adenosine triphosphate (ATP) production and are shuttled out of the mitochondria, providing precursors for nucleotide, amino acid, and lipid synthesis path- ways for the dividing cell [13]. (who.int)

Wnt-5a has since been suggested as a candidate ligand for ROR1, and ROR1 has been implicated to function as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells through interaction with Wnt-5a, and TCL1-co-activation of AKT. (peprotech.com)
Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
Low DHT levels elicit apoptosis of prostate secretory luminal cells and epithelial atrophyluminal epithelial apoptosis, but the histologic response to 5ARI treatment is often heterogeneous and lower urinary tract symptoms often persist, requiring surgical intervention. (ghenry.info)

Further, we provide a novel transcriptomics database of EXIQON and Affymetrix adipocyte profiles to facilitate data mining. (biomedcentral.com)

Better understanding of the cellular and molecular pathophysiological mechanisms regulating adipocyte size, number and depot-dependent expansion has become a focus of interest over recent decades. (springer.com)
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
In the past decade, better understanding of the cellular mechanisms responsible for successful soft tissue augmentation has been reported, focusing on the plentiful undifferentiated stromal elements rather than the survival of mature adipocytes. (journalofprolotherapy.com)
There are two main mechanisms in the adaptive immune system-humoral immunity and cellular immunity, which are mediated by antibodies and cells respectively. (frontiersin.org)
Although many related studies have been performed, differences in cell lines, experimental conditions and downstream mechanisms have generally resulted in contradictory findings. (nature.com)
Although OECs do always suit the traditional explanation of control cells, their features make them feasible candidates for cell therapy as well as study into the mechanisms controlling myelination. (cancer8.info)

Conversely, brown adipose tissue (BAT) and browning of WAT represent potential therapeutic approaches, since dysfunctional white adipocyte-induced lipid overspill can be halted by BAT/browning-mediated oxidative anti-lipotoxic effects. (springer.com)
Efficient manufacturing of therapeutic mesenchymal stromal cells with the use of the Quantum Cell Expansion System. (ctsicn.org)
This has fuelled the therapeutic interest in the transformation of energy-storing into energy-dissipating adipocytes. (news-medical.net)
1, 2 Recently, Prolotherapists have begun to utilize the potential of autologous adipose (fat)-derived stem/stromal cells (AD-SC) within non-manipulated fat graft scaffolding, combined with high-density PRP concentrates (HD-PRP) to provide a potent biological therapeutic combination. (journalofprolotherapy.com)
In the present study, the potential of using exosomes isolated from adipose‑derived stem cells (ADSCs) as a therapeutic tool for reducing chronic inflammation and promoting chondrogenesis was investigated using patient‑derived primary cells. (spandidos-publications.com)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)

These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin. (lookformedical.com)
In addition, white adipocytes provide insulation and contribute to endocrine function as they secrete hormones. (news-medical.net)

Conklin LS, Hanley PJ, Galipeau J, Barrett J, Bollard CM. Intravenous mesenchymal stromal cell therapy for inflammatory bowel disease: Lessons from the acute graft versus host disease experience. (ctsicn.org)
Mesenchymal stromal cell secretomes are modulated by suspension time, delivery vehicle, passage through catheter, and exposure to adjuvants. (ctsicn.org)
Quantitative activation suppression assay to evaluate human bone marrow-derived mesenchymal stromal cell potency. (ctsicn.org)
These observations suggest that molecular changes in the stromal cell compartment of bone may impact susceptibility to swelling. (informationalwebs.com)

Recently, an increasing number of studies have shown that adipocytes have immunological functions capable of recruiting and activating immune cells. (frontiersin.org)

This technique has produced a MAb specific to the cell surface of the chick osteOcyte,'6) to the murine PTH receptor,") and to OB-restricted antigens. (docksci.com)
Thus, as an alternative, we produced EXIQON microarray of brown and white primary murine adipocytes (prior to and following differentiation) to yield global profiles of miRNAs. (biomedcentral.com)

2003). Selective Cellular uptake of fatty acids and following storage in the form of disruption of Pparγ2 or adipocyte-speci﫿c Pparγ knockout leads TGs in adipocytes are key steps in lipid storage. (deepdyve.com)

In addition to its role in cancer development through epigenetic events, succinate is an extracellular signal transducer that modulates immune response, angiogenesis and cell invasion by activating its cognate receptor SUCNR1. (bvsalud.org)

Mesenchymal stem cells (MSCs), or stromal stem cells, can differentiate into many different types of … In contrast, treatments that utilize MSCs from a patientâ s fat (adipose) sample have shown weak or unreliable responses. (tomeipowered.com)
Mesenchymal stem cells (MSCs) are an example of tissue or 'adult' stem cells. (tomeipowered.com)
The original mesengenic process pathway (Figure 1) was hypothesized and fashioned … Two opposing descriptions of so-called mesenchymal stem cells (MSCs) exist at this time. (tomeipowered.com)
The problem is what a mesenchymal stem cell (MSCs) is isn't always clearly defined, which has led to confusion in the scientific community, as well as public misunderstandings exploited by businesses marketing questionable cell-based treatments, the authors argue. (tomeipowered.com)
Properties of Mesenchymal … We found that … Platelets are known to enhance the wound-healing activity of mesenchymal stem cells (MSCs). (tomeipowered.com)
Among the cell types that can be used for this purpose, mesenchymal stem cells (MSCs) are considered as promising source of stem cells in personalized cell-based therapies. (tomeipowered.com)
Mesenchymal stem/stromal cells (MSCs) are multipotent cells that are emerging as the most promising means of allogeneic cell therapy. (tomeipowered.com)
As the major cell precursors in osteogenesis, mesenchymal stem cells (MSCs) are indispensable for bone homeostasis and development. (nature.com)
A latest research demonstrated that a small percentage of perivascular cells in the human brain are MSCs [44, 45]. (cancer8.info)
Mesenchymal Stem Cells (MSCs) are a heterogeneous subset of stromal stem cells that originate from the mesoderm layer of the fetus. (tocris.com)

They have proinflammatory functions: they produce effector molecules (reactive oxygen and nitrogen intermediates) and inflammatory cytokines (IL-1 β , TNF α , and IL-6) and participate as inducer and effector cells in polarized Th1 responses. (hindawi.com)
With high levels of platelet-derived growth factors and cytokines, this combination provides both a living bioscaffold and a multipotent cell replenishment source useful for enhanced musculoskeletal healing. (journalofprolotherapy.com)
Next, we summarize various cytokines produced by adipocytes that regulate the survival, activation and differentiation of B cells. (frontiersin.org)

Insuf﫿cient adipose lipid storage is asso- ciated with many pathological conditions including hyperlipidemia, insulin resistance, and type 2 diabetes. (deepdyve.com)
Adipocyte Senp2 de﫿ciency resulted in less adipose lipid storage accompanied by an ectopic fat accumulation and insulin resistance under high-fat diet feed- ing. (deepdyve.com)
This mouse also showed an ectopic lipid in﫿ammation indicates that HFD induced adipocyte death would distribution and insulin resistance. (deepdyve.com)
adqcKO Mechanistically, adipocyte Senp2 de﫿ciency caused the downregula- Senp2 mice exhibit an ectopic lipid accumulation and tion of Pparg and Cebpa as well as their downstream target genes insulin resistance related to lipid storage. (deepdyve.com)

These actions are mediated by both the actions of a number of nonsecreted proteins and hormones produced in adipocytes. (diabetesjournals.org)
Examples of steroids include the dietary fat cholesterol, the sex hormones estradiol and testosterone, and the anti-inflammatory drug dexamethasone.The core. (absoluteastronomy.com)
It is used to produce hormones and cell membranes and is transported in the blood plasma of all mammals. (absoluteastronomy.com)
T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)

Adipocytes arise from the commitment and differentiation of adipose precursors in white adipose tissue (WAT). (nih.gov)
Epididymal white adipose tissue (WAT) from B6 wild type (Wt) and transgenic male mice overexpressing Agt (Agt-Tg) in adipose tissue and adipocytes treated with Ang II were used. (syr.edu)

UCP-1-expressing multilocular adipocytes, termed 'beige' or 'brite' (brown-in-white) adipocytes, can also be found interspersed among white adipocytes within SAT under conditions requiring increased heat production (e.g. chronic cold exposure). (springer.com)

The common stem cell produces 2 other stem cells, the myeloid stem cell and the lymphoid stem cell. (medscape.com)

Mesenchymal Stem Cells Instruction Manual Product Description Mesenchymal Stem Cells (MSC), also termed Mesenchymal Stromal Cells, are self-renewing multipotent cells that can differentiate into a wide variety of cell types. (tomeipowered.com)

ASP increases the efficiency of triacylglycerol synthesis in adipocytes leading to enhanced postprandial lipid clearance. (diabetesjournals.org)
Synthesis:Androstenedione is the common precursor of male and female sex. (absoluteastronomy.com)

We propose that overexpression of angiotensinogen (Agt), the precursor protein of RAS in adipose tissue or treatment of adipocytes with Angiotensin II (Ang II), RAS bioactive hormone, alters specific microRNAs (miRNA), that target ER stress and inflammation leading to adipocyte dysfunction. (syr.edu)

Upon Sox9 inactivation, these Pref-1 + cells become PDGFRα + cells that express early adipogenic markers. (nih.gov)
The availability of specific markers of the cell surface of the OB would be of great value in this task. (docksci.com)
Using nanoString GeoMx digital spatial profiling, we confirmed that histologically atrophied acini with expressing SCGB3A1 expression displayed higher levels of club cell markers compared to histologically normal, NKX3-1 expressing+ regions that retained prostate identity. (ghenry.info)

Mature adipocytes are known to play an important role controlling energy balance in mammals by storing fatty acids in the form of triglycerides in periods of excess of energy and by releasing fatty acids when are needed. (biomedcentral.com)
In addition, OBEX induced a clear reduction of the lipid load in mature adipocytes obtained from 3T3-F442A cells. (nature.com)
In addition, on the 3T3-F442A cell line, OBEX inhibited proliferation of pre-adipocytes, blocked the differentiation of pre-adipocytes into new adipocytes, and decreased the lipid load in mature adipocytes. (nature.com)
The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. (lookformedical.com)
WAT can transdifferentiate (transforms from one mature somatic cell type into another) into BAT. (news-medical.net)
Normally, only mature cells are released from the marrow into the bloodstream. (medscape.com)
Only mature blood cells contain the membrane proteins required to attach to and pass the blood vessel endothelium. (medscape.com)

Thus, we show that Pref-1 + cells precede PDGFRα + cells in the adipogenic pathway and that Sox9 inactivation is required for WAT growth and expansion. (nih.gov)

Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites. (lookformedical.com)
Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. (lookformedical.com)
Bone Marrow Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ctsicn.org)
This graph shows the total number of publications written about "Bone Marrow Cells" by people in this website by year, and whether "Bone Marrow Cells" was a major or minor topic of these publications. (ctsicn.org)
Below are the most recent publications written about "Bone Marrow Cells" by people in Profiles. (ctsicn.org)
The antigens appear to be localized to the cell surface of the osteoblast, with no apparent staining of bone matrix in either undecalcified or decalcified sections. (docksci.com)
MAbs UBIM 9 and 21 bind to marrow cells in long bone sections, to the 7-day-old nonadherent cell population from cultured marrow, and to lymphoid tissue in sections of spleen. (docksci.com)
In total, 1-10% of nucleated cells in adipose tissue are ADSCs, whereas only 0.0001-0.01% of nucleated cells in bone marrow are stem cells ( 5 ). (spandidos-publications.com)
Objective: This study evaluated the osteogenic induction of human bone marrow cells by human recombinant bone morphogenetic protein-4 (rhBMP-4) and proteins released by Saos-2 (human osteosarcoma cell line). (bvsalud.org)
Study design: Osteoinduction in the presence or absence of Saos-2 and/or rhBMP-4 was evaluated in cultured human bone marrow cells. (bvsalud.org)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
Bone marrow thus contains blood cells at varying stages of development. (medscape.com)
Illustration of the pelvis to show the site of bone marrow and blood cells derived from bone marrow. (medscape.com)
Similarly, the bone marrow produces and releases more white blood cells in response to infections, and it produces and releases more platelets in response to bleeding. (medscape.com)
As age progresses, more of the red bone marrow turns into yellow bone marrow and the production of new blood cells becomes more difficult. (medscape.com)
The bone marrow stroma contains mesenchymal stem cells. (medscape.com)

Undifferentiated mesenchymal stem cells are pluripotent cells that can differentiate into various phenotypes and are a source of osteogenic Cells 1,2 . (bvsalud.org)

Anatomy64

Organisms17

Diseases5

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes60

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Osteoblasts12

Proliferation and differentiation6

Chondrocytes2

Adipogenesis13

Differentiation into mature adipocytes1

Macrophage-like cells2

Induces2

Vitro7

Obesity13

Progenitor4

Differentiate into mature1

Early precursors2

Brown adipocytes5

Human adipocytes1

Tissues15

Metabolic7

Mesenchymal transition1

Regulation7

Adherent3

Hepatocytes3

Tumor8

Metabolism13

Vascular4

Vivo3

Preadipocytes4

Macrophages2

Glucose9

Immature1

Mesodermal1

Hematopoietic3

Lineages2

Leptin3

Mitochondria3

Apoptosis3

Affymetrix1

Mechanisms6

Therapeutic6

Secrete2

Stromal cell4

Immune cells1

Murine2

PPAR1

Extracellular1

MSCs10

Cytokines3

Insulin resistance4

Hormones4

White adipos2

Brite1

Myeloid1

Multipotent cells that can differentiate1

Synthesis2

Overexpression1

Markers3

Mature8

PDGFR1

Bone16

Pluripotent cells1