Cells in tumor metastasis. Medical search. Frequent questions

The latest paper suggests the microenvironment-the neighborhood of cells surrounding the tumor-is where stem cells can be recruited through altered cytokine-AR signals to boost prostate cancer metastasis. (rochester.edu)
These data suggested that miRs 130a and 145 skewed a pro-tumor toward an anti-tumor microenvironment via reprogrammed immature myeloid cells. (nih.gov)
CSCs are enriched near macrophages, particularly near macrophage-containing intravasation sites called Tumor Microenvironment of Metastasis (TMEM) doorways. (nature.com)
It has been suggested that tumor necroptosis affects tumor progression through modulating the tumor microenvironment. (biomedcentral.com)
On the other hand, intercellular transfer of mitochondria and cellular components via extracellular vesicles (EVs) and tunneling nanotubes (TNTs) has recently attracted intense attention in terms of cell-to-cell communication in the tumor microenvironment. (biomedcentral.com)
In this study, we investigated whether mtDNA with the NADH dehydrogenase subunit 6 ( ND6 ) G13997A pathogenic mutation in highly metastatic cells can be horizontally transferred to low-metastatic cells and stromal cells in the tumor microenvironment. (biomedcentral.com)
These results suggest that metastasis-enhancing pathogenic mtDNA derived from metastatic tumor cells is transferred to low-metastatic tumor cells and stromal cells via S-EVs in vitro and in the tumor microenvironment, inferring a novel mechanism of enhancement of metastatic potential during tumor progression. (biomedcentral.com)
Importantly, immune constituents of the tumor microenvironment (TME) can influence therapy response and cancer progression. (mdpi.com)
His laboratory investigates the tumor microenvironment in primary and metastatic disease. (metavivor.org)
In our study, we focus on the prognostic effects of TATE on HNSCC and how TATE can influence tumor behavior and tumor microenvironment. (nycu.edu.tw)
Lastly, we showed that HNSCC enriched with TATE is associated with immunosuppressive tumor microenvironment. (nycu.edu.tw)
Immunological and microbial processes in the tumor microenvironment of inflammation-associated and spontaneous colorectal carcinomas. (uniklinik-freiburg.de)
Welcome to the 5 th mini symposium in the Tumor immunology, Tumor microenvironment (TME) & metastasis LUCC network . (lu.se)
The tumor microenvironment in the context of colon cancer and with a focus on the inflammatory mediators leukotriene D 4 (LTD 4 ) and prostaglandins (PGE 2 ) and their respective receptors. (lu.se)
Our aim is to generate solid support for novel and complementary treatments of colon cancer patients that focus on the inflammatory component of the tumor microenvironment. (lu.se)
We investigate how the lack of these receptors affects tumour growth and the surrounding tumour microenvironment in different colon cancer models. (lu.se)
Her focus of research is the role of estrogen and thyroid hormones in colon cancer progression and their effects on inflammatory components of the tumor microenvironment, in a big female cohort. (lu.se)
Syrina is a pharmacist and her research in cell pathology focuses on neutrophils recruitment in colorectal cancers microenvironment and in cancer related inflammation. (lu.se)
Now, she is interested in the interaction between the immune cells (mainly mast cells) present in the colon cancer microenvironment and colon cancer cells. (lu.se)
Her focus is to target the tumor microenvironment for developing new and effective therapeutic strategies. (lu.se)

Importantly, CXCR3 expression in clinical breast cancer samples correlated with progression and metastasis. (oncotarget.com)
Here we show that nicotine significantly promotes the progression and metastasis of tumors in mouse models of lung cancer. (nih.gov)
These results suggest that while nicotine has only limited capacity to initiate tumor formation, it can facilitate the progression and metastasis of tumors pre-initiated by tobacco carcinogens. (nih.gov)

IGF1R inhibitor NT157 also decreased lung metastasis via improved anti-tumor immunity. (nih.gov)
Interestingly, systemic delivery of miR130a and miR145 improved anti-tumor immunity and efficacy of paclitaxel treatment. (nih.gov)
Taken together, these data suggested that miR130a and miR145 reprogramed Gr1+CD11b+ immature myeloid cells, and inhibited tumor metastasis via improvement of anti-tumor immunity. (nih.gov)
Here we report that targeting CXCR3 decreased tumor cell migration and at the same time improved host anti-tumor immunity. (oncotarget.com)
Consistently, targeting CXCR3 using a small molecular inhibitor (AMG487) significantly suppressed metastasis and improved host anti-tumor immunity. (oncotarget.com)
Collectively, our results suggest that RUNX3-mediated CCL5 repression is critical for modulating anti-tumor immunity. (nature.com)

These mutations were confirmed in patient lung metastases (n = 53) and were statistically associated with shorter median time to pulmonary metastasis. (nih.gov)
Renal cell carcinoma with pulmonary metastasis misdiagnosed as other primary malignant tumor. (bezmialem.edu.tr)
Injection of exosomes derived from RAB31 overexpressing cells promoted pulmonary metastasis in vivo. (bioinfor.com)
Natural News) In this study, researchers from Zhejiang Chinese Medical University investigated the effects of safflower yellow (SY), the active component of the herbaceous plant Carthamus tinctorius, on the pulmonary metastasis of breast cancer and its mechanism of action. (naturalnews.com)

During the metastasis, cancer cells in situ move to other tissues and organs from the blood circulation or the lymphatic system through proliferation, adhesion, invasion, and migration. (frontiersin.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Examination of human lung cancer samples and adjacent non-tumor tissues has revealed that Myo9b is upregulated in the majority of cancer samples. (northwestern.edu)
Edema, or swelling, occurs when fluid in or between the cells leaks into the body tissues. (medlineplus.gov)
We have identified a candidate etiologic agent, dubbed raccoon polyomavirus, that was present in the tumor tissue of all affected animals but not in tissues from 20 unaffected animals. (cdc.gov)
SCARA5 expression is significantly downregulated in various tumor tissues including liver cancer (LC), rectal cancer, and glioblastoma [ 15 , 16 ] and might affect cell proliferation and invasion abilities by the focal adhesion kinase (FAK) signaling pathway and epithelial-mesenchymal transition (EMT) [ 5 , 17 - 20 ]. (hindawi.com)
Mitochondrial DNA (mtDNA) carrying certain pathogenic mutations or single nucleotide variants (SNVs) enhances the invasion and metastasis of tumor cells, and some of these mutations are homoplasmic in tumor cells and even in tumor tissues. (biomedcentral.com)
FLIM technology is also used to analyse the autofluorescence of different tumour cells and tissues and to determine cell metabolism. (uni-ulm.de)
We investigated the expression of immune checkpoints (ICs) on lymphoid populations within the CRC TME and compared with cells from normal colon tissues using samples from 50 patients with varying disease stages. (mdpi.com)
The pituitary gland produces thyroid stimulating hormone (TSH) that goes into the blood stream to activate thyroid cells, which then secrete T3 and T4 into the peripheral tissues. (cdc.gov)
Tissues and Cells. (lu.se)
These mediators and their receptors are enriched in colon cancer cells and colon cancer tissues, which demonstrate there, contribute to tumor development and progression. (lu.se)

Investigators are starting to realize that tumor proliferation and tumor migration are two different things and should be treated as such," said Chang, the George Hoyt Whipple Distinguished Professor of Pathology, Urology, and Radiation Oncology at the University of Rochester and Wilmot Cancer Institute. (rochester.edu)
Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors. (whiterose.ac.uk)
Snail drives an EMT in tumor cells, which, although retaining some epithelial markers, subsequently break through the basal lamina of the midgut, undergo a collective migration and seed polyclonal metastases. (whiterose.ac.uk)
Knockdown (KD) of CXCR3 in metastatic tumor cells suppressed tumor cell migration and metastasis. (oncotarget.com)
Other studies reported that some cancer cells could repress their own CCL5 expression to hinder migration of anticancer immune cells toward cancer sites 15 , 16 . (nature.com)
This overlap made us question whether the so-called epithelial-mesenchymal factors -- which activate genes associated with cell movement and migration, which are common in embryo development and are also present in metastasis -- play a role in tumour initiation," says Casanova. (sciencedaily.com)
Invading cancer cells can utilize different modes of migration including single cell migration and collective migration. (jcancer.org)
Another focus of our work is on the cellular and molecular mechanisms governing migration of different types of cells, including neurons and non-neuronal cells. (northwestern.edu)
Either insufficient or excessive cell migration has been associated with age-related diseases including neurodevelopmental disorders, immune deficiencies, inflammation, and cancer metastasis. (northwestern.edu)
Our data show that Slit inhibits cancer cell migration by activating RhoA and that myosin 9b (Myo9b) is a Robo-interacting protein that suppresses RhoA activity in lung cancer cells. (northwestern.edu)
Systematic investigation using an integrated multi-disciplinary approach will help us not only understand fundamental mechanisms controlling cell migration in multiple biological processes but also discover new diagnostic biomarkers as well as therapeutic targets for a range of human diseases involving dys-regulation of cell migration. (northwestern.edu)
Support collective and independent migration to distal locations where they can form new tumors. (mayo.edu)
Many neuronal disorders, including epilepsy, schizophrenia and lissencephaly - a form of mental retardation - result from abnormal migration of nerve cells during the development of the brain. (news-medical.net)
Johns Hopkins researchers have found a way to directly observe cell migration -- in real time and in living tissue. (news-medical.net)
SCARA5 promoted cell proliferation and migration but inhibited apoptosis in ESCC. (hindawi.com)
In turn, CAFLCs-derived fibroblast activation protein (FAP) facilitated the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of GC cells. (ijbs.com)
To investigate the underlying mechanism of how TATE leads to poor clinical outcomes, we showed that activated eosinophils produce a variety of cytokines and chemokines, and activated TATE-derived culture medium promotes tumor migration mainly through CCL2. (nycu.edu.tw)

A recent study by cancer researcher Chawnshang Chang, Ph.D. , provides additional proof of a concept he's been investigating for years: that the environment surrounding a prostate tumor plays a major role in metastasis, and new treatments should be designed to target that environment as well as the tumor itself. (rochester.edu)
Published by the International Journal of Oncology , Chang's laboratory found that bone marrow derived stem cells, which are recruited to the site of a growing tumor, are able to convert nearby normal fibroblast cells into cancer cells, resulting in tumor metastasis. (rochester.edu)
Cancer metastasis is the leading cause of death in cancer patients. (frontiersin.org)
Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
Cancer metastasis is a complicated process, which is one of the main causes of the recurrence and death of cancer patients. (frontiersin.org)
Therefore, inhibiting cancer metastasis can be one of the strategies to effectively treat lung cancer. (frontiersin.org)
To this topic, lycopene had been demonstrated to have synergism from the combination of oxaliplatin in a human ovarian cancer cell line ( 20 ), suggesting that the adjuvant property on the anticancer of lycopene. (frontiersin.org)
Metastasis underlies the majority of cancer-related deaths yet remains poorly understood due, in part, to the lack of models in vivo. (whiterose.ac.uk)
Scholars@Duke publication: Metastasis dynamics for non-small-cell lung cancer: effect of patient and tumor-related factors. (duke.edu)
BACKGROUND: We studied event dynamics (probability of an event occurring over a specific time interval) in patients undergoing surgery for early-stage non-small-cell lung cancer (NSCLC) according to patient and tumor characteristics. (duke.edu)
Chemokines and chemokine receptors have critical roles in cancer metastasis and have emerged as one of the targeting options in cancer therapy. (oncotarget.com)
In addition to its roles in the regulation of inflammatory diseases and the maintenance of local immune cells, CCL5 expressed by cancer cells plays diverse roles in shaping cancer microenvironments toward their own survival. (nature.com)
Therefore, host CCL5 can obviously work as an anticancer molecule to mount relevant immune responses against some cancer cells. (nature.com)
Furthermore, a recent clinical trial for a CCR5 inhibitor treatment to patients suffering from liver metastasis of colorectal cancer showed its effect on reducing tumor mass with better prognosis, suggesting CCL5-CCR5 axis might also provide a procancer activity 22 . (nature.com)
Therefore, it might be safe to say that host CCL5 plays important roles in controlling cancer development but might create either pro- or anticancer environments according to the given situation, such as the type of cells that produce CCL5 and the type of cancers. (nature.com)
Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)
Mechanistically, stemness is induced in non-stem cancer cells upon their direct contact with macrophages via Notch-Jagged signaling. (nature.com)
In breast cancers from patients, the density of TMEM doorways correlates with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites. (nature.com)
90% of cancer-related deaths, is a multi-step process involving cancer cell intravasation into the bloodstream, dissemination to distant sites, and seeding in new organs 1 . (nature.com)
At the apex of the hierarchy are the cancer stem cells (CSCs). (nature.com)
Macrophages are emerging as major cellular factors in the tumor ecosystem that can influence the stem phenotype and cancer progression. (nature.com)
Although nicotine is generally thought to have limited ability to initiate cancer, it can induce cell proliferation and angiogenesis in a variety of systems. (nih.gov)
Our earlier results indicated that nicotine could induce invasion and epithelial-mesenchymal transition (EMT) in cultured lung, breast and pancreatic cancer cells. (nih.gov)
In cancer research, there has been a tendency to differentiate between the genes responsible for tumour development and those that give rise to metastasis and to study these processes separately since the cell functions required for these two mechanisms differ radically. (sciencedaily.com)
In particular, GATA genes are overexpressed in liver metastasis in colon cancer patients, as well as in several human tumours, such as those of the breast, ovary, pancreas and colon. (sciencedaily.com)
Once again, studies on Drosophila have contributed to our basic understanding of the behaviour of genes involved in cancer and metastasis, knowledge that will allow cancer researchers to pursue this line further," says the scientist. (sciencedaily.com)
Invasive micropapillary carcinoma of the breast (IMPC) is a rare subtype of breast cancer that has a high frequency of lymph node (LN) involvement and metastasis to distant organs. (jcancer.org)
Metastatic spread is responsible for the majority of cancer-associated deaths and is affected by a variety of factors, including the deregulation of gene expression, signal transduction, and epigenetic modification, as well as epithelial-to-mesenchymal transition (EMT) and the transformation of tumor cells into stem/progenitor cells. (jcancer.org)
We previously described a gene signature for breast cancer stem cells (BCSCs) derived from patient biopsies. (nih.gov)
Knockdown of RPL39 and MLF2 by specific siRNA nanoparticles in patient-derived and human cancer xenografts reduced tumor volume and lung metastases with a concomitant decrease in BCSCs. (nih.gov)
Brain metastasis (BrM) is the most common form of brain cancer, characterized by neurologic disability and an abysmal prognosis. (lu.se)
Scientists have long theorized that blood flow plays an integral role in cancer metastasis. (healthproblemsnews.com)
Techniques for analysis of single cell genomics, as well as protein expression on a single cell basis provide scientists with the capacity to understand cancer cell populations as a collection of individual cells, rather than as an average of all cells. (amegroups.org)
A multimodal combination of circulating tumor DNAs (ctDNAs), CTCs, proteomics, and CTC-derived xenografts (CDXs) to create computational models useful in diagnosis, prognostication, and predictiveness to treatment is likely the future of tailoring individualized cancer care. (amegroups.org)
Invariably, the development of new mutations, changes in cancer cell populations, and other resistance mechanisms lead to therapeutic resistance. (amegroups.org)
Thus, there exists the appeal of a so-called "liquid biopsy" that can less invasively act as a reliable surrogate for tumor biopsies, yet provide as much or even more information pertinent to cancer diagnosis, characteristics, and treatment options. (amegroups.org)
The first report of a CTC came in 1869 from Thomas Ashworth, who described the presence of tumor-derived epithelial cells in the blood compartment of a patient with end stage metastatic cancer, and postulated that this circulation of cells may account for the presence of multiple tumor metastases throughout the body of the patient ( 6 ). (amegroups.org)
An early approach was to identify the presence of free nucleic acids released from cancer cells into the blood by cancer cell apoptosis and necrosis, as well as by active secretion ( 8 , 9 ). (amegroups.org)
Emerging evidence indicates that the neuronal guidance molecule, Slit, plays a role in tumor suppression, as Slit-encoding genes are inactivated in several types of cancer, including lung cancer. (northwestern.edu)
In a murine model, Slit-expressing cancer cells (as compared to cancer cells in which Slit expression was silenced) had a decreased capacity for tumor formation and lung metastasis. (northwestern.edu)
Background Tumor metastasis due to circulating tumor cells (CTCs) makes up about 90% cancer-related loss of life world-wide. (healthanddietblog.info)
Capturing the suspensory cellsTo evaluate the efficiency of PE-5A-G6-5S-FITC conjugate at capturing the colon cancer cell lines YYA-021 SW620 and LoVo cell lines at the density of 106/mL were suspended in each tube. (healthanddietblog.info)
Restraining the captured CTCs for preventing cancer metastasis Cell viabilityTo investigate how the single and dual antibody conjugates (G6-5A G6-5S and G6-5A-5S) affected the cell proliferation MTT analysis was conducted as we previously described. (healthanddietblog.info)
Degradation of the extracellular matrix during metastasis is a necessary step in cancer progression. (mayo.edu)
Here, a pancreatic cancer cell is degrading a fluorescent matrix (green) as it migrates. (mayo.edu)
The five-year survival rate for people with these tumors is exceptionally poor due to a lack of effective therapies to target these cancer cells. (mayo.edu)
Scientists have identified a distinct subpopulation of cancer stem cells (CSCs) that is responsible for metastasis of a deadly human pancreatic cancer. (news-medical.net)
When cancer cells dissociate from the original tumor and migrate via the blood stream to colonize distant organs, is the main cause of cancer death. (news-medical.net)
In a report in Developmental Cell, the scientists say their advance could lead to strategies for controlling both normal growth and the spread of cancer, processes that depend on the programmed, organized movement of cells across space. (news-medical.net)
Mutations in the cell adhesion molecule known as integrin alpha 7 (integrin 7) lead to unchecked tumor cell proliferation and a significantly higher incidence in cancer spread, or metastasis, in several cancer cell lines, report researchers at the University of Pittsburgh School of Medicine in a study published in the Journal of the National Cancer Institute. (news-medical.net)
A new mathematical model uses the size of a cancer patient's initial, primary tumor to predict whether undetectable secondary tumors are already present. (medicalxpress.com)
As cancer grows, cells can spread from the initial tumor site to other parts of the body and establish secondary tumors called metastases. (medicalxpress.com)
The researchers used their model to estimate the fraction of patients with visible metastasis at surgery, as well as mean relapse times for several different cancer types. (medicalxpress.com)
Experiments in the literature on liver cancer (LC) were repeated to verify the functions of these genes in different tumors. (hindawi.com)
It is a tumor suppressor in various tumors, including LC and breast cancer (BC). (hindawi.com)
This case raises our awareness of such tumors as a differential diagnosis of colorectal cancer. (hindawi.com)
Tumor necroptosis often happens in advanced solid tumors, and blocking necroptosis by MLKL deletion in breast cancer dramatically reduces tumor metastasis. (biomedcentral.com)
Similarly, intercellular transfer of mitochondria-related EVs occurred between A11 cells and α-smooth muscle actin (α-SMA)-positive cancer-associated fibroblasts (CAFs, WA-mFib), macrophages (RAW264.7) and cytotoxic T cells (CTLL-2). (biomedcentral.com)
TAK-285 was examined in a model of breast cancer brain metastasis using direct intracranial injection of BT-474-derived luciferase-expressing cells and showed greater inhibition of brain tumor growth compared to animals treated with lapatinib. (jcancer.org)
The development of distant metastases negatively impacts quality of life and survival, and at least 10% of all cancer patients will develop brain metastasis ( 1 ). (jcancer.org)
Breast cancer is one of the most common primary tumors to develop associated brain metastases ( 1 , 2 ), and while recent progress in cancer therapy has improved control of primary breast tumors, methods to effectively treat brain metastases from breast cancer remain inadequate. (jcancer.org)
Wu H, Xiang Z, Huang G, He Q, Song J, Dou R, Yang C, Wang S, Xiong B. BGN/FAP/STAT3 positive feedback loop mediated mutual interaction between tumor cells and mesothelial cells contributes to peritoneal metastasis of gastric cancer. (ijbs.com)
Peritoneal metastasis (PM) is most frequent in gastric cancer (GC) and cancer-associated fibroblasts (CAFs) play a critical role in this process. (ijbs.com)
However, the concrete mechanism of crosstalk between CAFs and cancer cells in PM of GC remains unclear. (ijbs.com)
In vitro experiments demonstrated that BGN promoted tumor progression and the transformation of mesothelial cells (MCs) into cancer-associated fibroblasts like cells (CAFLCs). (ijbs.com)
Objective: In our study we aimed to evaluate the relationship of SUVmax of (18)FDG uptake (metabolic activity) of the primary tumor on the pretreatment PET-CT to local invasion, lymph node metastasis and distant organ metastasis in patients with non-small cell lung cancer (NSCLC). (gazi.edu.tr)
SOX9 regulates cancer stem-like properties and metastatic potential exposed cells. (cdc.gov)
SOX9 depletion also suppressed the formation of cancer stem-like cells (CSCs), as determined by tumor sphere formation and aldehyde dehydrogenase (ALDH) activity (Aldefluor) assays. (cdc.gov)
Cancer (also known as malignancy , pronounced: muh-LIG-nun-see) occurs when cells begin to grow and multiply in an uncontrolled way. (kidshealth.org)
But cancer cells continue to grow and divide and grow and divide. (kidshealth.org)
In this procedure, a doctor removes a small tissue sample to examine it for cancer cells. (kidshealth.org)
Cecilia Choy is currently pursuing her Ph.D. degree and specializes in HER2+ breast cancer brain metastasis research at City of Hope Cancer Center. (metavivor.org)
Tumor-associated tissue eosinophilia (TATE) is the presence of eosinophils in the tumor or in the neighboring stroma and has been observed in various types of cancer. (nycu.edu.tw)
Taken together, our results suggest that TATE promotes cancer metastasis and angiogenesis which results in a poor clinical outcomes in HNSCC. (nycu.edu.tw)
UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)
We demonstrate that UCN-01, at concentrations lower than those necessary to inhibit cancer cell growth, inhibit proliferation of human endothelial cells in vitro. (karger.com)
Since hypoxia activates hypoxia-inducible factor (HIF-1)-dependent transcription in cancer cells that, in a paracrine fashion, drive tumor angiogenesis, we investigated the effects of UCN-01 on HIF-1-responsive promoter constructs. (karger.com)
We report that, in addition to direct inhibitory effects on endothelial cell growth, UCN-01 abrogates hypoxia-mediated transactivation of HIF-1-responsive promoters in a prostate cancer cell line. (karger.com)
We conclude that UCN-01, at clinically relevant concentrations, exerts an anti-neovascularization effect by blocking two important steps in vessel formation: (1) the response of cancer cells to hypoxia, and (2) endothelial cell proliferation. (karger.com)
Scientists use nanobodies to target tumors: Can this technology be used for effective cancer detection? (naturalnews.com)
Natural News) The ability to spot tumors and metastases at an early stage would improve the survival chances of cancer patients. (naturalnews.com)
Natural News) In this study, a team of researchers from Nanjing University of Chinese Medicine in China studied the effects of a modified decoction of si jun zi on the metastasis of colorectal cancer cells. (naturalnews.com)
Natural News) The fruit of the greater burdock plant (Arctium lappa), referred to as niu bang zi or Arctii Fructus (AF) in traditional Chinese medicine, has been shown to prevent the spread of colorectal cancer cells, according to a study in The American Journal of Chinese Medicine. (naturalnews.com)
arations verified the presence of cancer cells in all samples. (lu.se)
Fewer than 5% of patients with small cell lung cancer (SCLC) are asymptomatic at presentation. (medscape.com)
Squamous cell cancer also presents as a central lesion, but unlike small cell carcinoma, it frequently exhibits central cavitation. (medscape.com)
Prediction of lymph node metastasis in breast cancer by gene expression and clinicopathological models: Development and validation within a population based cohort. (lu.se)
The American Joint Committee on Cancer (AJCC) TNM classification and the International Federation of Gynecology and Obstetrics (FIGO) staging system for germ cell tumors are listed below (see Tables 1 and 2). (medscape.com)
Lubnas research is mainly focused on the tumor suppressor protein 15-hydroxyprostaglandin dehydrogenase which is known to be down-regulated in colon cancer. (lu.se)
She is investigating two different ligands and their receptive G-protein coupled receptors WNT5A/Frizzle and cysteinyl leukotriene C4/CysLTR2 signaling pathways which both upregulates 15-PGDH and induce re-differentiation of colon cancer cells. (lu.se)
Her research involves methods as tissue microarray (TMA) of colon cancer patients for immunohistochemistry (IHC) and Western blot, qPCR, transfection, luciferase assay, immunofluorescens on colon cancer cell lines. (lu.se)
Ovarian granulosa cell tumor and increased risk of breast cancer. (cancercentrum.se)

Testicular germ cell tumors (TGCT), evenly divided into two histologic types, seminomas and nonseminomas, are the most common malignancy among males between ages 15 to 44 years [1, 2]. (utrgv.edu)
Management of ovarian germ cell tumors. (medscape.com)
Pauniaho SL, Salonen J, Helminen M, Vettenranta K, Heikinheimo M, Heikinheimo O. The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland. (cancercentrum.se)
The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)

Restoration of miRs 130a and 145 functions in immature myeloid cells might be useful for reduction of tumor metastasis. (nih.gov)
We found that blocking tumor necroptosis by MLKL deletion led to the dramatic reduction of tumor metastasis and significantly elevated anti-tumor activity of tumor-infiltrating and peripheral blood T cells. (biomedcentral.com)

Researchers have demonstrated that genes activated during metastasis are also able to initiate primary tumor development, and they explain the molecular mechanism involved. (sciencedaily.com)
Researchers headed by Jordi Casanova at the Institute for Research in Biomedicine (IRB Barcelona) now demonstrate that genes activated during metastasis are also able to initiate primary tumour development, and they explain the molecular mechanism involved. (sciencedaily.com)
He goes on to say "And that is that the same genes can activate tumour growth and metastasis, and therefore some tumours are conferred metastatic capacity from their very outset. (sciencedaily.com)
The study is based on the observation that benign human tumours or tumours at stages well before metastasis express some genes associated with this process. (sciencedaily.com)
Jordi Casanova's team examined various genes, among them Serpent (homologue of GATA in Drosophila), and demonstrated that the overexpression of this gene is indeed sufficient to drive tumour growth. (sciencedaily.com)
Therefore, it is important to explore candidate genes that could have significance to the clinical diagnosis, as well as the treatment of esophageal squamous cell carcinoma (ESCC) at the molecular level [ 4 ]. (hindawi.com)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)

Most pancreatic neuroendocrine tumors (islet cell tumors) are functional tumors. (medicinenet.com)
Pancreatic neuroendocrine tumors can be benign (noncancerous) or malignant (cancerous). (medicinenet.com)
What are the stages of pancreatic neuroendocrine tumors? (medicinenet.com)
What are the signs or symptoms of pancreatic neuroendocrine tumors? (medicinenet.com)
Pancreatic neuroendocrine tumors may be functional or nonfunctional. (medscape.com)
Overall, the age-adjusted incidence of neuroendocrine tumors increased sixfold from 1973 (1.09 per 100,000) to 2012 ((6.98 per 100,000), possibly because of increased early detection. (medscape.com)

however, the mechanism by which RAB31 regulates exosome secretion and promotes metastasis remains to be clarified. (bioinfor.com)

We report on a 77-year-old man presenting with extremity weakness who was found to have a 2.5 cm brain metastasis from a subsequently discovered 1.6 cm clear cell RCC primary tumor. (canjurol.com)
However, these drugs have little effect on brain metastasis due to the combined effects of poor penetration of the blood-brain barrier and their removal from the central nervous system (CNS) by the p-glycoprotein (Pgp) drug efflux pump. (jcancer.org)

Other symptoms from distant metastasis may include pain from bone metastasis, as well as jaundice or abdominal/right upper quadrant pain due to liver metastasis. (medscape.com)

We aimed to elucidate the microenvironmental changes in the process of lymphatic metastasis of lung squamous cell carcinoma. (elsevierpure.com)
In lung squamous cell carcinoma, drastic microenvironmental changes (e.g., growth factor receptor expression and proliferative capacity of tumor cells and structural changes in stromal cells) occur during both the process of lymphatic permeation and the progression into macrometastases. (elsevierpure.com)
Thrombospondin type 1 domain-containing 7A ( THSD7A ) was reported to play a procancer role in esophageal squamous cell carcinoma (ESCC). (hindawi.com)
In head and neck squamous cell carcinoma (HNSCC), the clinical relevance of TATE has not been concluded yet because of the inconsistent results in different studies. (nycu.edu.tw)
To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oral squamous cell carcinoma (OSCC) and the difference in its expression level between positive and negative HPV-16 (human papilloma virus- 16) OSCC patients. (bvsalud.org)
The recurrence is a serious prognostic influence in patients with oral squamous cell carcinoma (OSCC) 1-3 . (bvsalud.org)
2014) 16 reported and compared the histologic, immunohistochemical and clinical features as well as the survival rates of carcinoma arising in patients with PVL (p-scca) and conventional squamous cell carcinoma (c-scca). (bvsalud.org)

Furthermore, HNSCC enriched with TATE had more aggressive pathological features, including regional lymph node metastasis, perineural invasion, lymphovascular invasion, and tumor growth. (nycu.edu.tw)

Immature myeloid cells, identified as Gr1+CD11b+ cells, are expanded in tumor bearing host, and promote distant organ metastasis in tumor bearing host through production of immunosuppressive cytokines and chemokines. (nih.gov)

A factor-specific modulation of peak heights that ranged from no impact (eg, race) to relevant effects for primary tumor size, nodal involvement, and pleural invasion, possibly related to sex, was also observed. (duke.edu)
This metastatic behavior of tumor cells is the single most important factor affecting survival, as 90% of mortality is due to metastatic invasion. (mayo.edu)
Metastatic tumors involving colon are rare, accounting for only 0.338% of all colorectal malignancies in a large multi-institutional study, when lymphoproliferative diseases, direct invasion, and mesenteric and peritoneal spreading are excluded [ 1 ]. (hindawi.com)
We and others previously showed that certain mitochondrial DNA (mtDNA) somatic mutations or single nucleotide variants (SNVs) enhanced the invasion and metastasis of mouse and human cell lines, e.g. (biomedcentral.com)
Invasion and Metastasis (1998) 18 (4): 209-218. (karger.com)

The event of interest was the development of distant metastases, with or without a local recurrence. (duke.edu)

Ectopic miR130a or miR145 expression decreased T¿RII expression in Gr1+CD11b+ cells and significantly inhibited lung metastasis. (nih.gov)
For the host compartment, deletion of CXCR3 in all host cells in 4T1 mammary tumor model significantly decreased metastasis. (oncotarget.com)
In comparing the clinicopathological features of 451 IMPC patients and 282 IDC-NST patients, our results showed that tumor emboli were significantly higher in IMPC patients and were associated with a high frequency of metastasis. (jcancer.org)
Furthermore, the frequency of predicted pathogenic mtDNA mutations was significantly correlated with distant metastasis in patients with non-small cell lung carcinoma (NSCLC) and colon cancers [ 2 ]. (biomedcentral.com)
We found that the levels of B cells, T cells, and NK cells were similar, IC-expressing CD4 + and CD4 + CD8 + double positive T cells were higher, while CD8 + T cells and CD4 − CD8 − double negative T cells were significantly lower in CRC tumors. (mdpi.com)

Our resource provides a foundation to understand the molecular basis of BrM in patients with tumor cell-intrinsic and host environmental traits. (lu.se)
The researchers next applied these findings to study brain metastases in 100 human patients from with heterogeneous primary tumor locations. (healthproblemsnews.com)
For many patients, the primary tumor is surgically removed and no metastases are detected. (medicalxpress.com)
Incidentally, the resected tumor sizes for real patients often fall into this problematic range," Antal says. (medicalxpress.com)
Researchers conducted a single-arm, nonrandomized phase 2 trial, involving 217 unique patients with 285 lung tumors, at an academic center in the United States and one in Japan, to assess whether individualizing lung SABR dose provides good local control and fewer toxicities. (medscape.com)
Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
At presentation, patients may have very large intrathoracic tumors, and distinguishing the primary tumor from lymph node metastases may be impossible. (medscape.com)
Patients with symptomatic brain metastases may have raised intracranial pressure secondary to mass lesions and vasogenic edema. (medscape.com)
Archival tumour tissue from primary tumours and metastasis from patients included in clinical trials is characterised on protein and genomic level and the results linked to clinical outcome. (lu.se)
Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)

Small cell carcinomas usually grow rapidly and metastasize to mediastinal lymph nodes relatively early in the course of the disease. (medscape.com)

We review what is known about synchronous and metachronous metastasis from small renal tumors and prognostic features informing treatment for such lesions. (canjurol.com)
Herein, we review the history and the current status of CTC detection, discuss the prognostic, predictive, and diagnostic capabilities of these technologies, and describe application of CTCs as models for the study of tumor biology. (amegroups.org)
The K-M survival analysis indicated that SCARA5 expression quantity was not related to prognosis, but tumor volume and T classification were both the independent prognostic factors. (hindawi.com)
Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)
Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. (cancercentrum.se)

Is Islet Cell Tumor a Neuroendocrine Tumor? (medicinenet.com)
Is an Islet Cell Tumor a Neuroendocrine Tumor? (medicinenet.com)
An islet cell tumor, also known as a pancreatic neuroendocrine tumor , forms in hormone-producing cells (islet cells) of the pancreas. (medicinenet.com)

I think this is an important addition to understanding how and where tumor cells would eventually form metastases. (healthproblemsnews.com)

Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice xenografted with Lewis lung carcinoma (LLC) cells. (frontiersin.org)
In anti-metastatic studies, lycopene has been found to inhibit the metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice ( 17 ). (frontiersin.org)
Using Lys-Cre mediated myeloid specific Tgfbr2 knockout mice, TGF¿ type II receptor (TbRII) in myeloid cells inhibit tumor metastasis. (nih.gov)
To examine whether miRs130a and 145 inhibit lung metastasis via down-regulation of T¿RII in immature myeloid cells, we used 2 different mouse models with myeloid specific miR130a or miR145 overexpression: 1) 4T1 tumor model transplanted with CD11b driven-miR130a or miR145 engineered bone marrow haematopoietic stem /progenitor cells and 2) Lewis lung carcinoma model with doxycycline-inducible myeloid specific miR130a transgenic mice. (nih.gov)
IFN-γ neutralization diminished the metastasis inhibition in the CXCR3 knockout (KO) mice bearing 4T1 tumors, suggesting a critical role of host CXCR3 in immune suppression. (oncotarget.com)
Here, we employ high-resolution intravital microscopy using a CSC biosensor to directly observe CSCs in live mice with mammary tumors. (nature.com)
In the present study, Line1 mouse adenocarcinoma cells were implanted subcutaneously into syngenic BALB/c mice. (nih.gov)
This study demonstrates for the first time that administration of nicotine either by i.p. injection or through over-the-counter dermal patches can promote tumor growth and metastasis in immunocompetent mice. (nih.gov)
They further confirmed this observation in brain metastases in mice using intravital correlative microscopy, an imaging technique developed by the Goetz laboratory, in collaboration with Y.Schwab (EMBL, Heidelberg), which combines imaging living multicellular model systems with electron microscopy to provide details of dynamic or transient events in vivo. (healthproblemsnews.com)
Furthermore, transgenic mice harboring the viral-encoded large T-antigen (LT-Ag) alone develop tumors of neuroectodermal origin, including malignant peripheral nerve sheath tumors (MPNSTs) and glioblastomas. (cdc.gov)
Importantly, the increased anti-tumor activity of T cells is a key cause for the reduced metastasis as the depletion of CD8+ T cells completely restored the level of metastasis in the Mlkl KO mice. (biomedcentral.com)
Interestingly, the levels of some soluble cell surface proteins including sE-cadherin that are known to promote metastasis are also dramatically reduced in MLKL null tumors/mice. (biomedcentral.com)
Administration of ADAMs pan inhibitor reduces the levels of soluble cell surface proteins in WT tumors/mice and leads to the dramatic decrease in metastasis. (biomedcentral.com)

The presence of metastases is associated with a poorer prognosis and calls for additional treatment. (medicalxpress.com)

The metastasizing cells penetrate the blood vessel wall by invasiveness, and migrate in the circulation, extravasate out of the blood vessels, colonize in the distant tissue, initiate angiogenesis, and finally grow at the new site ( 2 , 3 ). (frontiersin.org)
Deletion of the proximal enhancer decreases CCL5 expression and augments the cytotoxic activity of tissue-resident T and NK cells, which coincides with reduced melanoma metastasis in mouse models. (nature.com)
Recent studies using neutralizing anti-CCL5 antibodies have suggested that the constitutive expression of CCL5 plays a regulatory role in maintaining tissue-resident memory (Trm) T cells in the human vaginal tract 9 and mouse skin 10 , suggesting that constitutive CCL5 expression in noninflamed conditions, hereafter referred to as homeostatic CCL5 expression, might be important for homeostasis of tissue-resident lymphocytes. (nature.com)
In mammary gland development, Notch-dependent heterotypic signaling between resident tissue macrophages and mammary stem cells supports survival and function of the normal mammary stem cell 20 . (nature.com)
In this regard, this gene causes overgrowth of the wing, modifies tissue structure, and activates a series of genetic changes in order to facilitate initial tumour growth. (sciencedaily.com)
Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes, that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. (wikipedia.org)
Oxygen from the red blood cells, and nutrients in the fluid then diffuse into the tissue. (medlineplus.gov)
Given the tumor distribution, patient was suspected of having pancreatic lymphoma and underwent endoscopic ultrasound-guided tissue sampling of the tumor. (utrgv.edu)
Sometimes cells from a tumor break away and travel to a different tissue or organ. (kidshealth.org)

Evidence that PyVs induce tumors after natural infection is accumulating but more controversial. (cdc.gov)
We found that SOX9 is upregulated in SWCNT-exposed cells, which is consistent with their abilities to induce tumor formation and metastasis in vivo. (cdc.gov)

This model opens the door to investigate the basic mechanisms underlying metastasis, in a powerful in vivo system suited for rapid genetic and drug screens. (whiterose.ac.uk)
The underlying mechanisms involve a decreased expression of IL-4, IL-10, iNOs, and Arg-1 in myeloid cells and an increased T cell response. (oncotarget.com)
These viral proteins also interact with other several cellular factors and lead to revoke normal cell cycle checkpoint stand cell death mechanisms 13 . (bvsalud.org)

Metastasis and growth in neoplastic lesions requires the multistep regulation of microenvironmental factors. (elsevierpure.com)
Our findings revealed a key role for RAB31 in GC metastasis through regulation of exosome secretion. (bioinfor.com)
Taken together, our findings provide a mechanistic insight into SWCNT-induced carcinogenesis and the role of SOX9 in CSC regulation and metastasis. (cdc.gov)

Studies have suggested that statins may inhibit tumor cell growth and possibly prevent carcinogenesis. (cdc.gov)
More than 15 years ago, cholesterol decrement was first shown to inhibit tumor cell growth, metastasis of tumor cells, and induction of apoptosis (7). (cdc.gov)

The lab's investigators explore how the metastatic behavior of tumor cells is regulated to discover new treatments for lung, liver and pancreatic cancers. (mayo.edu)
In mouse and rat xenograft tumor models, TAK-285 showed antitumor activity against cancers that expressed HER2 or EGFR. (jcancer.org)
Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)
General references Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)

Both in vitro and in vivo data showed overexpression of plakoglobin in both the cell membrane and the cytoplasm of IMPC clusters. (jcancer.org)
Cells overexpressing RAB31 showed an enhanced ability to migrate in both the in vitro cell model and the pulmonary metastatic model of GC. (bioinfor.com)
Indeed, SOX9 knockdown inhibited anchorage-independent cell growth in vitro and lung colonization in vivo in a mouse xenograft model. (cdc.gov)

The most common primary site of colorectal metastasis is the breast, followed by the lung and malignant melanoma [ 1 ]. (hindawi.com)
Here, we report a case of ACC metastatic to the colon 19 years after resection of the primary tumor, to broaden the differential diagnosis of colorectal malignancies and to better understand the clinical, histological, and molecular features of ACC. (hindawi.com)

While metastases re-epithelialize over time, we found that early metastases are remarkably mesenchymal, discarding the requirement for a mesenchymal-to-epithelial transition for early stages of metastatic growth. (whiterose.ac.uk)
Previous studies showed that myeloid specific transforming growth factor beta (TGF¿) signaling is essential for tumor metastasis. (nih.gov)
CSCs have an enhanced ability to self-renew, which makes them uniquely capable of initiating and sustaining primary and metastatic tumor growth 3 . (nature.com)
These properties might enable nicotine to facilitate the growth of tumors already initiated. (nih.gov)
We believe that exposure to nicotine either by tobacco smoke or nicotine supplements might facilitate increased tumor growth and metastasis. (nih.gov)
No woman is too young to know that regular breast self-examinations can help to catch tumors earlier in their growth, hopefully before they spread or metastasize. (medlineplus.gov)
Future work could extend the model by incorporating more complex aspects of tumor growth. (medicalxpress.com)
Adenoid cystic carcinoma (ACC) is a tumor characterized by slow growth and late distant metastasis. (hindawi.com)
Signs and symptoms are often caused by the growth and spread of the tumor. (medicinenet.com)
The signs or symptoms are either caused by the growth of the tumor and/or by the hormones produced by the tumor. (medicinenet.com)
The clinical manifestations of SCLC can result from local tumor growth, intrathoracic spread, distant spread, and/or paraneoplastic syndromes. (medscape.com)
Common symptoms resulting from local tumor growth include cough, dyspnea, and hemoptysis. (medscape.com)
Rapid tumor growth may lead to obstruction of major airways, with distal collapse leading to postobstructive pneumonitis, infection, and fever. (medscape.com)

Development of most solid tumors is characterized by an increase in secretion and activation of matrix metalloproteinases (MMPs) produced by either the tumor cells or tumor-associated fibroblasts. (bvsalud.org)

Using mouse models, we validated the metastatic potential of tumor clusters was higher than single cells in vivo . (jcancer.org)

Tumor-related studies have shown the clinical application and research prospects of this gene, suggesting that it might play the important role in the treatment of tumors. (hindawi.com)
Here, we report a case of ACC arising from minor salivary gland that metastasized to the colon 19 years after the primary tumor resection, with literature review of the clinical, histological, and molecular features of ACC. (hindawi.com)
Although nonfunctional islet cell tumors are not uncommon at autopsy, most islet cell tumors with clinical manifestations are functional. (medscape.com)
Functioning tumors produce a clinical syndrome as a result of excessive hormone production. (medscape.com)
Clinical features of the syndrome depend on tumor cell type. (medscape.com)
To obtain an independent test set, the remaining 11 of the 58 tumors were selected from an ongoing clinical trial and used here as a blinded sion via ER,3 however the details of the estrogen effect on down- test set. (lu.se)
The prediction models integrate patient´s, clinical and tumour related data to achieve high accuracy. (lu.se)

Furthermore, macrophages were shown to contribute to a niche that can support and maintain a breast CSC (BCSC) phenotype through heterotypic CD90/EphA4 signaling between macrophage and tumor cell 14 . (nature.com)
We interrogated the composition of BrM niches, molecularly defined the blood-tumor interface, and revealed stromal immunosuppressive states enriched with infiltrated T cells and macrophages. (lu.se)

K441 and R443 together make up a membrane-binding motif that allows EphA2 receptors to attach to the cell membrane. (wikipedia.org)
The iodine hormone exerts its action on receptors on the nucleus in cells. (cdc.gov)

Chang data's suggests several targeted treatment possibilities, by either interrupting the conversion process, or preventing the recruitment of stem cells from taking place. (rochester.edu)
primary human leukemic stem cells and human glioblastoma models. (helsinki.fi)
Researchers have shown that bone marrow stem cells injected into a damaged inner ear can speed hearing recovery after partial hearing loss. (news-medical.net)
In this study, we linked SOX9, a stem cell associated transcription factor, to the neoplastic-like properties of human lung epithelial cells chronically exposed to a low-dose of single-walled carbon nanotube s (SWCNTs). (cdc.gov)
Furthermore, SOX9 knockdown suppressed tumor metastasis and the expression of the stem cell marker ALDH1A1. (cdc.gov)

This is because they tend to migrate away from the site of the primary tumor to invade distal organs. (mayo.edu)
Primary tumors can spread towards distant organs as single cells, when they lose a protein called E-cadherin. (news-medical.net)

We initially determined that miRs 130 and 145 can directly target Tgfbr2 mRNA by mouse miRNA expression assay, and were down-regulated in Gr1+CD11b+ myeloid cells from 4T1 or Eo771 mammary tumor model. (nih.gov)
To evaluate therapeutic potentials of miRs130a and 145 mimics for lung metastasis, we used a preclinical mouse model with 4T1 mammary tumor. (nih.gov)
Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)

Anatomy20

Organisms8

Diseases77

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes42

Disciplines and Occupations1

Information Science5

Health Care10

Microenvironment20

Progression and metastasis3

Anti-tumor immunity6

Pulmonary metastasis4

Tissues12

Migration17

Cancer92

Germ cell t5

Reduction of tumor metastasis2

Genes8

Neuroendocrine tumors6

Promotes Metastasis1

Brain metastasis2

Liver metastasis1

Squamous7

Regional lymph node metastasis1

Distant organ metastasis1

Invasion5

Development of distant metastases1

Significantly5

Patients10

Lymph Nodes1

Prognostic5

Islet cell3

Form metastases1

Mice13

Prognosis1

Tissue9

Induce2

Mechanisms3

Regulation3

Inhibit tumor2

Cancers4

Vitro3

Colorectal2

Growth13

Solid tumors1

Vivo1

Clinical7

Macrophages2

Receptors2

Stem5

Organs2

Mammary3