Cells generate cardiac muscle. Medical search. Frequent questions

The flow of these ions is essential for creating the electrical impulses that start each heartbeat and coordinate contraction of the cardiac muscle . (medlineplus.gov)
Researchers believe that the MYH6 gene variation changes the structure of myosin, which can affect cardiac muscle contraction and increase the likelihood of developing an abnormal heartbeat. (medlineplus.gov)
When someone has a "heart attack" (cardiac arrest) where the heart stops beating altogether, an electric signal is sent across cardiac muscle using a defibrillator to reset the electric signals generated by pacemaker cells to restore a coordinated contraction of cardiac muscle. (flashcardmachine.com)
[2] These signals are generated rhythmically, which results in the coordinated rhythmic contraction and relaxation of the heart. (wikipedia.org)
This influx of calcium causes calcium-induced calcium release from the sarcoplasmic reticulum , and free Ca 2+ causes muscle contraction . (wikipedia.org)
Leslie explains how action potentials are generated by the cardiac cells of the heart and how the release of calcium can generate heart contraction . (interactive-biology.com)
My name is Leslie Samuel and in this episode, Episode 47, I'm going to be talking about action potentials and contraction in cardiac muscle cells. (interactive-biology.com)
For a refresher of how that works, you can go back to Episode 42 where I talked about calcium release and how that causes muscle contraction. (interactive-biology.com)
Except for Purkinje cells, they are generally much smaller than the contractile cells and have few of the myofibrils or filaments needed for contraction. (lumenlearning.com)
A junction between two adjoining cells is marked by a critical structure called an intercalated disc , which helps support the synchronized contraction of the muscle. (lumenlearning.com)
They consist of desmosomes, specialized linking proteoglycans, tight junctions, and large numbers of gap junctions that allow the passage of ions between the cells and help to synchronize the contraction. (lumenlearning.com)
The importance of strongly binding these cells together is necessitated by the forces exerted by contraction. (lumenlearning.com)
Cardiac myocytes are excessive strength cells accountable for wearing the maximum bodily lively cells within side the frame due to the fact they perform the myogenic contraction of the complete cardiac muscle. (crn-ccrc.org)
The underlying mechanisms of contraction ( excitation-contraction coupling and the sliding filament mechanism ) are similar in all muscle types. (amboss.com)
The ratio between potassium concentration in the intracellular fluid (ICF) and concentration in the extracellular fluid (ECF) strongly influences cell membrane polarization, which in turn influences important cell processes, such as the conduction of nerve impulses and muscle (including myocardial) cell contraction. (msdmanuals.com)
The cardiac cycle refers to events that occur during one heart beat and is split into ventricular systole (contraction/ejection phase) and diastole (relaxation/filling phase). (medscape.com)

H9c2 cardiac myoblasts, neonatal rat cardiac myocytes, and HEK293 cells expressing ß1/ß2 adrenoceptors were stimulated with several agonists and antagonists. (bvsalud.org)
It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow. (centralx.com)
The human cardiac (heart) muscle consists of unmarried cardiac myocytes. (crn-ccrc.org)
The coordinated interaction of the myofilaments actin and myosin within the myocytes gives muscle tissue the ability to contract. (amboss.com)
In myocardial infarction , cardiac myocytes are damaged as a result of absolute oxygen deficiency and release their intracellular content into the bloodstream. (amboss.com)
Overview of Arrhythmias The normal heart beats in a regular, coordinated way because electrical impulses generated and spread by myocytes with unique electrical properties trigger a sequence of organized myocardial. (msdmanuals.com)

In the model organism NC cells generate an amazing array of tissues, including peripheral and enteric nervous systems, cranial bones and cartilage, some cardiac muscle and virtually all pigmented cells in the body. (ca.gov)
Direct reprogramming into tissues that contain multiple cell types has not previously been reported, and it could open new pathways in the regenerative medicine field," Yoon says. (emoryhealthsciblog.com)
CD140b is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues. (thermofisher.com)
From what I had learned from my reliable sources, I think the electrical charge you'd mentioned was the ATP in the muscle tissues which generate an electrical impulses called an action potential. (selfgrowth.com)
Early efforts at replicating cardiac tissues consisted of geometrically simple structures, made by casting cardiomyocytes in an ECM-based gel. (3dprintingindustry.com)
In addition, such tissues could generate force, but weren't able to pump fluid, which further restricted their ability to mimic vascular structures. (3dprintingindustry.com)
Cells specified as mesoderm at early stages will go on to form tissues such as blood, skeletal muscle, cardiac muscle, cartilage and bone, whereas endoderm cells will form liver, lung, pancreas and gut. (kcl.ac.uk)
By identifying the programs of gene expression that lead to the formation of these cells types we hope to be able to recapitulate them in the lab and generate cells that could be used for repair and replacement of damaged tissues in humans. (kcl.ac.uk)
Included in these are the muscularization from the ventrolateral mesoderm or hypomere to create branchiomeric muscle tissues and the introduction of two book ectodermal buildings: the Gadodiamide (Omniscan) neurogenic placodes as well as the neural crest. (biobender.com)
Neural crest cells make a lot of the cartilage bone tissue dentine and various other connective tissues from the vertebrate mind whereas the placodes bring about the Gadodiamide (Omniscan) sensory neurons that are crucial for the forming of vertebrates' complicated sensory systems2-4. (biobender.com)
Amount 1 The stunning heterogeneity from the individual mind and center musculature Amount 2 An evolutionarily conserved cardiopharyngeal ontogenetic theme A collection of regulatory elements integrates the intercellular indicators that coordinate the forming of cardiac Gadodiamide (Omniscan) and branchiomeric muscle tissues from a common pool of mesodermal progenitor cells. (biobender.com)
Dendritic cells and macrophages found in large quantities at the corticomedullary junction arise from mesodermal tissues (bone marrow). (medscape.com)
The epithelial cells and these other stromal tissues of the thymus influence the selection and maturation of the T lymphocytes. (medscape.com)
Total nucleic acids were retrospectively extracted from lar mechanisms related to the switch from the acute to the flash-frozen cardiac tissues by using NucliSens easyMAG persistent CV-B infection in human cardiac tissue are still instrument protocols (bioMérieux, Marcy l'Etoile, France) unknown, but they could be related to terminal deletions according to the manufacturer's instructions. (cdc.gov)
All tissues originate from stem cells. (bvsalud.org)
A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)
Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)

The conduction system consists of specialized heart muscle cells , situated within the myocardium . (wikipedia.org)
In a functional syncytium, electrical impulses propagate freely between cells in every direction, so that the myocardium functions as a single contractile unit. (wikipedia.org)
Cardiovascular diseases are the leading cause of death in highly developed industrial countries and are characterized by their affect on the heart muscle, also known as myocardium. (stanford.edu)
The myocardium consists of cardiac muscle cells, called cardiomyocytes, which are responsible for generating contractile force required for rhythmic heart beats. (stanford.edu)
Cardiac muscle is also under involuntary control of cardiac pacemaker cells and forms the walls of the cardiac chambers ( myocardium ). (amboss.com)
Early differentiating cardiac progenitor cells from the initial center field (FHF) bring about the linear center tube and afterwards form the still left ventricle and elements of the atria8 9 Subsequently second-heart-field (SHF) progenitors situated in pharyngeal mesoderm generate cardiac muscle mass (myocardium) from the outflow system correct ventricle and elements of the atria10-12 (Fig. 2). (biobender.com)

We investigate intracellular dynamics in photosynthetic systems, research contractility mechanisms in cardiac and skeletal muscle cells, and study structural organization of cancerous tissue. (utoronto.ca)
When someone has a myocardial infarction, what has happened to the cardiac muscle tissue? (flashcardmachine.com)
During this process, leukocytes lose lineage-associated markers home and undergo homocytic aggregation, upregulate expression of stem cell antigens, and subsequently redifferentiate to give rise original tissue or, transdifferentiate into a different tissue altogether. (eurekaselect.com)
The robustness and efficacy of the retrodifferentiation process in generating unprecedented quantities of stem cells belonging to the three germ layers will enable organ and tissue reconstruction ex vivo, using bio-printing and various scaffold materials. (eurekaselect.com)
Epimorphic regeneration and retrodifferentiation both have the capacity to recreate and reconstruct tissue with precise positional integration of cells in such a way that will enable us to heal without scars and to understand how to maintain tissue integrity and architecture in the face of a hostile environment. (eurekaselect.com)
Bypassing stem cells, Emory scientists can now create engineered heart tissue by directly reprogramming connective tissue cells in mice. (emoryhealthsciblog.com)
This is the first study demonstrating direct tissue reprogramming from single adult cells from the body," says senior author Young-sup Yoon , MD, PhD, professor of medicine at Emory University School of Medicine. (emoryhealthsciblog.com)
Other scientists have shown they can create human heart tissue from induced pluripotent stem cells ( example ), but the Emory team showed that it is possible to avoid stem cells and the technologies required to create them, such as viruses. (emoryhealthsciblog.com)
Applying a combination of growth factors, regulatory microRNA and vitamins, the Emory researchers could create tissue that contains cardiac muscle, along with blood vessels containing endothelial cells and smooth muscle cells, and fibroblasts. (emoryhealthsciblog.com)
In culture, the four cell types weave themselves together, bypassing any need to build heart tissue from separate components. (emoryhealthsciblog.com)
When transplanted onto the damaged heart of a mouse after a simulated heart attack, cells from the engineered tissue can migrate into the host heart, and improve its functioning. (emoryhealthsciblog.com)
In some previous studies, when a tissue patch composed of engineered cells and supportive biomaterials was transplanted to the damaged heart, there was little or no migration of cells from the patch to the host heart," Yoon says. (emoryhealthsciblog.com)
The researchers checked whether their transplanted tissue induced cardiac arrhythmias in the mice - a danger when introducing immature cells into the damaged heart - and they did not. (emoryhealthsciblog.com)
The researchers behind the work used RNAs to instruct cells in an injured heart to eliminate scar tissue and recreate cardiac muscle, allowing the heart to function like new again. (news-medical.net)
Like the scars on skin that result from injury or surgery, the scar tissue generated in the heart after a heart attack is tough and nonflexible and can prevent the organ from functioning at its full potential, Hodgkinson said. (news-medical.net)
Hodgkinson and his team wanted to find an efficient way to convert the scar tissue back into functioning cardiac muscle to essentially reverse the effects of a heart attack. (news-medical.net)
To do this, they set out to find a way to transform fibroblasts, a type of cell that contributes to the formation of connective tissue, into heart muscle cells via a process called cellular reprogramming. (news-medical.net)
The ability of excitable tissue to generate and propagate action potentials depends upon the electrical properties of the cell membrane at rest. (wfsahq.org)
3 The oxygen consumption of the mammalian retina (per gram of tissue) is nearly 50% greater than that of the kidney, three times greater than the cerebral cortex and six times that of cardiac muscle. (arn.org)
The muscle tissue of the HEART. (centralx.com)
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. (lookformedical.com)
Intercellular connective tissue also helps to bind the cells together. (lumenlearning.com)
Muscle tissue is a soft tissue that is primarily composed of long muscle fibers. (amboss.com)
Depending on the intracellular arrangement of these myofilaments , muscle tissue is classified as either striated (skeletal and cardiac) or nonstriated (smooth) muscle. (amboss.com)
An increase in blood cardiac troponin levels thus indicates cardiac muscle tissue damage. (amboss.com)
Capillaries carry blood to tissue cells and are the exchange sites of nutrients, gases, wastes, etc. (medscape.com)
The right and left coronary arteries branch from the ascending aorta and, through their branches (anterior and posterior interventricular, marginal and circumflex arteries), supply the heart muscle (myocardial) tissue. (medscape.com)
They are subdivided into larger conducting arteries, smaller distributing arteries, and the smallest arteries, known as arterioles, that supply the capillary bed (the site of active tissue cells gas exchange). (medscape.com)
The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)
These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)

Like a neuron, a given myocardial cell has a negative membrane potential when at rest. (wikipedia.org)
In response to that, what's going to happen is that the membrane potential of the cardiac muscle cells is all of a sudden going to depolarize very quickly. (interactive-biology.com)
What is the resting membrane potential in cardiac cells? (freezingblue.com)

Cardiovascular diseases are a broad group of diseases that are responsible for complications such as cardiac arrhythmia, strokes, and myocardial infarction. (stanford.edu)

On the microscopic level, the wave of depolarization propagates to adjacent cells via gap junctions located on the intercalated disc . (wikipedia.org)
While gap junctions -- interconnecting molecular bridges thatconjoin tightly packed cells -- are known to generate calcium signalsand transport other molecules between cells, the researchers say thetunneling nanotubules are something quite different. (sciencedaily.com)
This is clearly a third form of intercellular communication,distinct from gap junctions and synapses used by nerve cells. (sciencedaily.com)
And, itis possible that tunneling nanotubules are essential for the functionof the immune system, just as gap junctions are critical for thefunction of cardiac muscle. (sciencedaily.com)
c) An intercalated disc connects cardiac muscle cells and consists of desmosomes and gap junctions. (lumenlearning.com)
Adjacent cardiac cells are connected by intercalated discs containing desmosomes and gap junctions. (medscape.com)

The cardiac conduction system (CCS) (also called the electrical conduction system of the heart ) [1] transmits the signals generated by the sinoatrial node - the heart 's pacemaker , to cause the heart muscle to contract , and pump blood through the body's circulatory system . (wikipedia.org)
Embryologic evidence of generation of the cardiac conduction system illuminates the respective roles of this specialized set of cells. (wikipedia.org)
When the signal is generated in the SA node and it spreads to the atria , the conduction velocity is one meter per second (1 m/s). (interactive-biology.com)
In vivo visualization and molecular targeting of the cardiac conduction system. (stanford.edu)
The myocardial conducting cells (1 percent of the cells) form the conduction system of the heart. (lumenlearning.com)
Myocardial conduction cells initiate and propagate the action potential (the electrical impulse) that travels throughout the heart and triggers the contractions that propel the blood. (lumenlearning.com)

The SA node generates electrical impulses that start each heartbeat. (medlineplus.gov)

Cardiac myositis may cause heart failure, cardiac arrhythmia, and sudden death. (medscape.com)
In this genetic association study of 413 adults who had unexplained SCD, nearly one-fifth of individuals had pathogenic or likely pathogenic genetic variants consistent with inherited cardiomyopathies or arrhythmia syndromes, despite having normal cardiac findings. (cdc.gov)

When a cell with an excitable membrane is not transmitting impulses it is said to be at rest. (wfsahq.org)
Contractile cells conduct impulses and are responsible for contractions that pump blood through the body. (lumenlearning.com)

If our hypothesis is correct, hES cell-derived neural precursors will be a rich source for NC cells, and subsequently for an array of human NC derivatives such as bones, cartilage, muscles, peripheral and enteric neurons and melanocytes. (ca.gov)
Cardiac muscle has some similarities to neurons and skeletal muscle, as well as important unique properties. (wikipedia.org)
The research proves cells other than neurons are capable of long-distance communication and reveals a hereto-unknown mechanism cells use for exchanging information. (sciencedaily.com)
The research not only proves cells other than neurons arecapable of long-distance communication, but it reveals a hereto-unknownmechanism cells use for exchanging information. (sciencedaily.com)
Their function is similar in many respects to neurons, although they are specialized muscle cells. (lumenlearning.com)
It is widely expressed, and appears on the surface of prostatic epithelium, endothelial cells, vascular and visceral smooth muscle, mammary epithelium, cardiac muscle, keratinocytes and neurons. (novusbio.com)

In a recent eLife paper , Hanjoong Jo's lab characterizes a "flow-kine": a protein produced by endothelial cells in response to healthy blood flow patterns. (emoryhealthsciblog.com)
KLK10 acts in a different way, not affecting cholesterol, but instead inhibiting inflammation in endothelial cells. (emoryhealthsciblog.com)
KLF2 has a similar protective function, but it is expressed inside endothelial cells and stays inside the cell. (emoryhealthsciblog.com)

This protein plays an important role in skeletal muscles, which the body uses for movement, and in heart (cardiac) muscle. (medlineplus.gov)
Several variants (also known as mutations) in the TTN gene have been found to cause centronuclear myopathy, a condition that is characterized by muscle weakness (myopathy) in the skeletal muscles. (medlineplus.gov)
Several variants in the TTN gene have been found to cause hereditary myopathy with early respiratory failure (HMERF), an inherited disease that affects muscles used for movement (skeletal muscles) and muscles that are needed for breathing (respiratory muscles). (medlineplus.gov)
It is unclear why these effects are usually limited to certain skeletal muscles and respiratory muscles, and do not involve cardiac muscle. (medlineplus.gov)
When the muscle cells depolarize, as with skeletal muscles, we're going to have calcium being released from the sarcoplasmic reticulum . (interactive-biology.com)
[ 4 ] MG is caused by autoantibodies to postsynaptic nicotinic acetylcholine receptors (anti-AChRs) at the neuromuscular junction, causing weakness of skeletal muscles. (medscape.com)

Divergent early mesoderm specification underlies distinct head and trunk muscle programmes in vertebrates. (ncbs.res.in)
Whereas the developmental route of trunk muscles from mesoderm is well studied, that of head muscles is ill defined. (ncbs.res.in)
This twin potential is the defining feature of cardiopharyngeal mesoderm: the head subtype giving rise to heart and branchiomeric head muscles. (ncbs.res.in)
Therefore, our findings provide compelling evidence that dual inhibition specifies head mesoderm and unravel the mechanism that diversifies head and trunk muscle programmes during early mesoderm fate commitment. (ncbs.res.in)
In response to ligation of monomorphic regions of MHC class II antigens with monoclonal antibody CR3/43, human leukocytes retrodifferentiate into a variety of heterogeneous stem cell types belonging to the mesoderm, ectoderm or endoderm lineage, depending on culture media and conditions. (eurekaselect.com)
Our main focus is on gene regulation during the formation of mesoderm and endoderm - two basic cell types that form in the early embryo. (kcl.ac.uk)

Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. (medlineplus.gov)

They found that the mutations create an abnormality within vital structures of heart cells known as the ATP-sensitive potassium channel. (sciencedaily.com)
Duchenne muscular dystrophy (DMD), an X-linked genetic disorder characterized by progressive muscle weakness and atrophies affecting skeletal and cardiac muscles, is caused by mutations in dystrophin (DMD) gene that spans 79 exons. (hpscreg.eu)
These rare diseases are often the underlying cause of sudden cardiac death in young individuals and result from mutations in several genes encoding ion channels or proteins involved in their regulation. (cdc.gov)

After a delay, potassium channels reopen, and the resulting flow of K + out of the cell causes repolarization to the resting state. (wikipedia.org)
However, in cardiac muscle cells, we have calcium that's being released that slows down the repolarization process and we get a phase that's referred to as the 'plateau. (interactive-biology.com)
Then, at a certain point, calcium gets pumped back into the sarcoplasmic reticulum, potassium also leaves as usual, and we get the repolarization of the cardiac muscle cells. (interactive-biology.com)

The PI laboratory has recently developed an efficient procedure for the rapid differentiation of human ES cells into uniform neural precursors (hES-NPCs), which was hitherto unachievable. (ca.gov)
To pursue Aim1 we will use in situ hybridization, immunostaining, prospective isolation of candidate NC cells by FACS and in vitro differentiation analysis to determine the vitro fates of candidate human NC cells. (ca.gov)
However, the in vitro differentiation conditions for all potential human NC cell fates are unknown. (ca.gov)
Significantly, this is the first report of directed differentiation of pluripotent stem cells, without transgenes, into progenitors with muscle/heart dual potential. (ncbs.res.in)
Together, our work provides the scientific community with a powerful new genetic lineage tracing approach as well as a single cell transcriptomic atlas of hiPSCs undergoing cardiac differentiation. (stanford.edu)
This approach could be applied to many other cell types with poor proliferative and migratory capacity following differentiation," stated the research team. (3dprintingindustry.com)
The correct regulation of gene activation and repression is crucial both for cell types to become established during embryonic development and for on-going differentiation of stem cells in the adult. (kcl.ac.uk)
Understanding the programs that control gene expression and underlie cell differentiation is thus central to many aspects of human health. (kcl.ac.uk)
We use a combination of approaches to study gene regulation during cell differentiation including experimental embryology, molecular biology, genomics, proteomics and computational biology in a variety of systems including zebrafish and mammalian cells. (kcl.ac.uk)

they are made of proteins that generate the mechanical force needed for muscles to contract. (medlineplus.gov)
Titin interacts with other muscle proteins, including actin and myosin, to keep the components of sarcomeres in place as muscles contract and relax. (medlineplus.gov)
Such precursors include alanine (derived from the breakdown of proteins in skeletal muscle) and glycerol (derived from the breakdown of triacylglycerols in fat cells). (medscape.com)
Actins are highly conserved globular proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (caslab.com)
Beta and gamma 1 are two non-muscle actin proteins. (caslab.com)
Jo sees similarities between KLK10 and myokines , exercise-induced proteins secreted by skeletal muscle cells. (emoryhealthsciblog.com)
This work differs from most research into genetic causes of heart failure which has identified defects in proteins involved in the mechanics of cardiac pumping, not in the communication pathways of stress-management systems. (sciencedaily.com)
In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)

a) Cardiac muscle cells have myofibrils composed of myofilaments arranged in sarcomeres, T tubules to transmit the impulse from the sarcolemma to the interior of the cell, numerous mitochondria for energy, and intercalated discs that are found at the junction of different cardiac muscle cells. (lumenlearning.com)
Cardiac muscle cells are branching striated, uninucleate (single nucleus) cells that contain myofibrils. (medscape.com)

Remarkably, the progenitors derived from embryonic stem cells by dual inhibition efficiently differentiate into cardiac and skeletal muscle cells. (ncbs.res.in)
During mammalian development, the left and right ventricles arise from early populations of cardiac progenitors known as the first and second heart fields, respectively. (stanford.edu)

Abnormal sarcomeres prevent muscle cells from contracting and relaxing normally, resulting in the muscle weakness that is characteristic of centronuclear myopathy. (medlineplus.gov)
These muscle abnormalities underlie the characteristic features of EOMFC, including skeletal muscle weakness and a form of heart disease called dilated cardiomyopathy. (medlineplus.gov)

In addition, the sarcoplasmic reticulum stores few calcium ions, so most of the calcium ions must come from outside the cells. (lumenlearning.com)

Nerves and muscle (including, importantly, cardiac muscle) can both generate and propagate action potentials. (wfsahq.org)
Which cells have fast response action potentials? (freezingblue.com)

We compared this data with existing murine and 3D cardiac organoid scRNA-seq data and confirmed the dominance of left ventricular cardiomyocytes (>90%) in our hiPSC-derived progeny. (stanford.edu)
Furthermore, we conduct a cross-species prediction of cardiomyocyte subtypes from in vitro-derived human induced pluripotent stem cells and unexpectedly uncover a predominance of left ventricular (LV) identity that we confirmed by an LV-specific TBX5 lineage tracing system. (stanford.edu)
The main inherited cardiac arrhythmias are long QT syndrome, short QT syndrome, catecholaminergic polymorphic ventricular tachycardia and Brugada syndrome. (cdc.gov)

Ability to generate branchiomeric muscle could catalyse efforts in modelling myopathies that selectively involve head muscles. (ncbs.res.in)

Novel role of silent information regulator 1 in acute endothelial cell oxidative stress injury. (rndsystems.com)
This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)
The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)

Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)

Cardiac muscle undergoes aerobic respiration patterns, primarily metabolizing lipids and carbohydrates. (lumenlearning.com)
Cardiac muscle has abundant mitochondria that depend on aerobic respiration primarily to generate adenosine tri-phosphate (ATP), the molecule that provides energy for cellular function (see the images below). (medscape.com)

Slightly different versions (called isoforms) of titin are made from the TTN gene in different muscles. (medlineplus.gov)
These variants result in the production of an abnormal titin protein, particularly isoforms that are found in cardiac muscle. (medlineplus.gov)
In addition, several smaller isoforms like 35 kDa were also seen in western blot analyses of human cell lysates. (bvsalud.org)
The expression of these isoforms varies between different cancer cell lines of human origin. (bvsalud.org)
They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. (lookformedical.com)

ICIs used in cancer therapy can cause serious cardiac immune-related side effects. (stanford.edu)

2023) Neonatal and adult cardiac fibroblasts exhibit inherent differences in cardiac regenerative capacity. (news-medical.net)

These studies documented normal cardiac function and normal morphology of the coronary arteries. (biomedcentral.com)

Within muscle cells, titin is an essential component of structures called sarcomeres. (medlineplus.gov)
The defective protein disrupts the function of sarcomeres, preventing skeletal and cardiac muscle from developing and working normally. (medlineplus.gov)
Cardiac muscle also demonstrates striations, the alternating pattern of dark A bands and light I bands attributed to the precise arrangement of the myofilaments and fibrils that are organized in sarcomeres along the length of the cell. (lumenlearning.com)
The myofilaments of striated muscle are arranged into sarcomeres while smooth muscle myofilaments lack a specific arrangement. (amboss.com)

We found that if you take cardiac fibroblasts from juveniles, they reprogram very nicely. (news-medical.net)
The researchers were able to harness the regenerative capacity of young cells by blocking Epas1 in adult fibroblasts. (news-medical.net)
When we reversed the fibroblast aging process, essentially making the fibroblasts think they were young again, we converted more fibroblasts into cardiac muscle," Hodgkinson said. (news-medical.net)
Exosome packages have unique properties that guide them to cardiac fibroblasts inside an injured heart. (news-medical.net)
We were able to recover almost all of the cardiac function that was lost after a heart attack by reversing the aging of the fibroblasts in the heart," Hodgkinson said. (news-medical.net)

The sarcolemmas from adjacent cells bind together at the intercalated discs. (lumenlearning.com)
2 The amniote center comprises of cardiomyocytes produced from two adjacent progenitor cell populations in the first embryo7. (biobender.com)

Changes in sarcomere function reduce the heart's ability to contract, weakening cardiac muscle and leading to the signs and symptoms of familial dilated cardiomyopathy. (medlineplus.gov)

Abnormalities in NC cells involved in numerous human pathologies including various skeletal syndromes (e.g. (ca.gov)
Of those, about 27% (approximately 3,000) have abnormalities of the heart muscle (including irregular heart rhythm) as an underlying cause. (medindia.net)
At higher levels of exposure in humans, lead produces cardiac lesions and electrocardiographic abnormalities. (cdc.gov)

Researchers are studying how abnormally folded titin contributes to the muscle damage underlying the signs and symptoms of HMERF. (medlineplus.gov)
The researchers formulated a cocktail of RNAs and packaged them into exosomes, a natural product produced by most cells. (news-medical.net)
This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival. (rndsystems.com)
Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular diseases. (jci.org)
This is affected by capillarization, mitochondrial density, and the composition of muscle fiber types. (roadbikeaction.com)
Endurance training improves muscle capillarization and mitochondrial density, and can shift the composition of muscle fiber type. (roadbikeaction.com)

However, consideration of the very high energy demands of the photoreceptor cells in the vertebrate retina suggests that rather than being a challenge to teleology the curious inverted design of the vertebrate retina may in fact represent a unique solution to the problem of providing the highly active photoreceptor cells of higher vertebrates with copious quantities of oxygen and nutrients. (arn.org)
Indeed the high acuity and high sensitivity of the visual system in higher vertebrates is critically dependent on the very high metabolic rates of the photoreceptor cells. (arn.org)

Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. (lookformedical.com)

Blood-derived dendritic cells and macrophages, bothantigen-presenting cells, make use of these so-called tunnelingnanotubules to relay molecular messages, report Simon C. Watkins,Ph.D., and Russell D. Salter, Ph.D. Further research may show there areadditional cell types with these microscopic tunnel connections. (sciencedaily.com)
Using a custom-built, multi-camera live cell microscopicimaging system, they report that, in a matter of seconds, dendriticcells and macrophages can send waves of calcium and other smallmolecules to cells hundreds of micrometers away. (sciencedaily.com)
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. (elifesciences.org)
Specific absence of homeostatic, monocyte-independent macrophages altered the immune cell crosstalk in response to injury and induced proinflammatory neutrophil polarization, resulting in impaired cardiac remodelling without influencing infarct size. (elifesciences.org)
In summary, resident macrophages orchestrate inflammatory responses improving cardiac remodelling, while recruited macrophages determine infarct size after I/R injury. (elifesciences.org)
This study provides important findings on the distinct functions of resident and recruited macrophages during cardiac healing after myocardial ischemia. (elifesciences.org)
Using state-of-the-art fate-mapping models and genetic and pharmacological targeting approaches, the authors provide solid evidence that the absence of resident macrophages do not influence infarct size but instead alter the immune cell crosstalk in response to injury. (elifesciences.org)

Disruption of Drosophila larval muscle structure and function by UNC45 knockdown, BMC Mol. (utoronto.ca)
He did not have any cardiovascular risk factors, and his cardiac function and morphology were normal prior to sorafenib treatment. (biomedcentral.com)
Cardiac function was investigated, including coronary angiography and transthoracic and transesophageal echocardiography. (biomedcentral.com)
The authors are the first to explain the function of tunnelingnanotubules, structures that were first described in fruit flies in1998, and subsequently, identified in a handful of different types ofanimal and human cells. (sciencedaily.com)
Synthesis of steroids from cholesterol made in vivo because the acetate and those thought to fulfil the study file, but may also affect p-glycoprotein or other problems such as partners, relatives, employers, coworkers, and emotional experience associated with homosexual practices because of its structure and function of pancreatic fl-cells, resulting in the mucosal cells, the fore associated with. (themauimiracle.org)
Vitamin-like CoQ10 helps generate energy for the cells to function at their optimum level. (medindia.net)
This augmented adverse remodelling after I/R and led to an increased infarct size and deterioration of cardiac function. (elifesciences.org)
2) T cell deficiencies affect the function in killing infected cells or helping other immune cells. (lu.se)

It's one thing to find that this intricate physical networkexists but quite astonishing to learn that immune system cells areusing it to relay molecular signals to one another," said Dr. Watkins,professor and vice chair, department of cell biology and physiology,and director of the Center for Biologic Imaging, University ofPittsburgh School of Medicine. (sciencedaily.com)
Frontiers in Cell and Developmental Biology. (kcl.ac.uk)
Research team leader Andre Terzic, M.D., Ph.D., a specialist in cardiac biology, describes the work as groundbreaking because it reveals critical molecular mechanisms which may in turn point to possible new treatments for heart failure. (sciencedaily.com)

human pluripotent stem cell (hPSC)-derived myoblasts may be cultured on cultureware coated with Corning® Matrigel® hESC-Qualified Matrix. (stemcell.com)
Human induced pluripotent stem cells (hiPSCs) present an exciting alternative for modeling early human embryogenesis due to their well-established ability to differentiate into all embryonic germ layers. (stanford.edu)
The cell-laden biomaterial, produced using pluripotent stem cells, allowed the research team to 3D print an aortic replica with more chambers, ventricles and a higher cell wall thickness than was previously possible. (3dprintingindustry.com)
ES cells are pluripotent cells, which mean that they can give rise to all differentiated cell types derived from all three germ layers. (bvsalud.org)

Smooth muscle is under involuntary control of the autonomic nervous system and external stimuli (e.g., chemical, mechanical). (amboss.com)

Based on their origin, there are two main types of stem cells - embryonic stem cells (ES cells) and postnatal or adult stem cells (AS cells). (bvsalud.org)
Embryonic stem cells are stem cells derived from the inner cell mass of an early, preimplantation stage embryo known as a blastocyst. (bvsalud.org)

To demonstrate the power of devCellPy, we construct a murine cardiac developmental atlas from published datasets encompassing 104,199 cells from E6.5-E16.5 and train devCellPy to generate a cardiac prediction algorithm. (stanford.edu)
These cells can be characterized in their developmental progression by changes in expression of 3 cell surface markers: CD4, CD8, and the T-cell receptor (TCR)-CD3 complex. (medscape.com)
The lymphocytes' selection process and developmental progression are influenced by direct contact between the TCR-CD3 complex on the thymocyte and the major histocompatibility complex (MHC)-antigen complex on thymic epithelial cells, dendritic cells, and B lymphocytes. (medscape.com)

heart failure, cardiac arrest, and stroke. (medlineplus.gov)
The heart is a functional syncytium as opposed to a skeletal muscle syncytium . (wikipedia.org)
There's an important feature about the heart muscle cells that you need to be aware of. (interactive-biology.com)
This is why we get the heart contracting in response to the signal that's generated by the SA node. (interactive-biology.com)
If heart muscle is damaged by a heart attack, the damaged or dead cells do not regenerate. (emoryhealthsciblog.com)
But after transplantation, the engrafted cells mature and integrate into the host heart. (emoryhealthsciblog.com)
Once they have a heart attack or any type of damage, there's no capacity to replace the heart muscle that dies. (news-medical.net)
Currently, our experience is that nearly all cases of new-onset heart failure are diagnosed only when the patient has reached a state of severe decompensation, and less than 50% of children who present with such symptoms of heart failure survive for five years without cardiac transplantation. (medindia.net)
The main causes in developed countries are primary cardiomyopathies, or diseases of the heart muscle (which account for 60% of children requiring a cardiac transplant), and congenital heart diseases. (medindia.net)
Even though cardiac muscle has autorhythmicity, heart rate is modulated by the endocrine and nervous systems. (lumenlearning.com)
Cardiac Output: the volume of blood your heart can move in a minute. (roadbikeaction.com)
As the heart muscle adapts to training, stroke volume increases, which increases cardiac output. (roadbikeaction.com)
What 2 kinds of cells make up the heart? (freezingblue.com)
The pumping action of the heart usually maintains a balance between cardiac output and venous return. (medscape.com)
A normal heart rate is approximately 72 beats/minute, and the cardiac cycle spreads over 0.8 seconds. (medscape.com)
These defects make the heart muscle susceptible to damage. (sciencedaily.com)
It: 1) for the first time, views heart failure as a communication or signaling problem in the stress-management system of heart cells, 2) tests the idea in human beings, and 3) offers convincing evidence that miscommunication of stress signals distresses the heart and plays a role in susceptibility to heart failure. (sciencedaily.com)
Too much calcium damages cell structure and leads to heart failure. (sciencedaily.com)

The generated iPSCs line (SDQLCHi007-A) carrying the identical deletion of 49-50 exons, expresses pluripotency markers, presents a normal karyotype and is able to differentiate into three germ layers. (hpscreg.eu)
In the normal thymus, bone marrow-derived precursor cells destined to become thymocytes (or T lymphocytes) enter the thymus at the corticomedullary junction and differentiate as they pass through the thymus. (medscape.com)

Unlike most cells in the hu- man body, cardiomyocytes are terminally differentiated and can no longer undergo the process of cell division. (stanford.edu)
Cardiac muscle cells undergo twitch-type contractions with long refractory periods followed by brief relaxation periods. (lumenlearning.com)

The protein produced from the MYH6 gene forms part of a larger protein called myosin, which generates the mechanical force needed for cardiac muscle to contract. (medlineplus.gov)
Myofilaments are protein fibers consisting of thick ( myosin ) and thin ( actin ) filaments and are responsible for the contractile properties of muscle cells. (amboss.com)

Ensure high yields when passaging and culturing your primary human skeletal muscle progenitor cells (myoblasts) by using MyoCult™-SF Attachment Substrate, which is optimized to support myoblast attachment. (stemcell.com)

Atta-ur-Rahman, Shazia Anjum , " Frontiers in Stem Cell and Regenerative Medicine Research ", Bentham Science Publishers (2017). (eurekaselect.com)
Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
Regenerative endodontic procedures can be defined as biologically based procedures designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex. (bvsalud.org)
The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
The most valuable cells for regenerative endodontics are postnatal or adult stem cells. (bvsalud.org)

Inside the CPF there is certainly significant overlap in the appearance of genes that encode cardiogenic regulatory elements (for instance (also called (also called capsulin) (also called is required inside the CPF for both center and mind muscles development and may be the main applicant gene for the congenital condition DiGeorge symptoms (or 22q11.2 deletion symptoms) which is seen as a a spectral range of cardiovascular flaws and craniofacial anomalies. (biobender.com)

For more information on protocols for the derivation and expansion of human skeletal muscle progenitor cells with MyoCult™, please explore the Product Information Sheet . (stemcell.com)

Variants in the TTN gene have been identified in people with early-onset myopathy with fatal cardiomyopathy (EOMFC), an inherited disease that affects both skeletal and cardiac muscle. (medlineplus.gov)
Some patients with thymoma-associated MG have an inflammatory myopathy of striated and cardiac muscles. (medscape.com)

Typically, cardiomyocytes have a single, central nucleus, but two or more nuclei may be found in some cells. (lumenlearning.com)
b) A photomicrograph of cardiac muscle cells shows the nuclei and intercalated discs. (lumenlearning.com)

During limb epimorphic regeneration: committed mesenchymal cells at the stump site dedifferentiate, forming a cluster of heterogeneous population of stem cells, known as the blastema. (eurekaselect.com)
The hematopoietic retrodifferentiated stem cells have been shown to engraft an animal host in two proofs of principle clinical studies, demonstrating long-term engraftment and safety in acquired aplastic anaemia, while transient amelioration of beta thalassemia major was also observed. (eurekaselect.com)
The ease by which various stem cell types can be generated from human peripheral blood has allowed the design of various kits to guarantee the specificity, sterility and efficacy of stem cells production for various clinical and research applications. (eurekaselect.com)
It could serve as a platform for cell-based therapy by avoiding the problems of current stem cell-based approaches, and for disease modeling and drug development. (emoryhealthsciblog.com)
To date, four types of human dental stem cells have been isolated and characterized: (i) dental pulp stem cells (DPSCs) 12 (ii) stem cells from exfoliated deciduous teeth (SHED) 21 (iii) stem cells from apical papilla (SCAP) 31 (iv) periodontal ligament stem cells (PDLSCs) 28 . (bvsalud.org)
Leukocytes are produced in stem cells in bone marrow. (lu.se)

Venous blood collected by the cardiac veins (great, middle, small, and anterior) flows into the coronary sinus. (medscape.com)
The SHF could be split into anterior and posterior progenitor Gadodiamide (Omniscan) cell populations that donate to the arterial and venous poles from the center respectively8. (biobender.com)

Then, when it reaches the AV node and it spreads via the Purkinje fibers, that signal spreads to all of the muscle cells in the ventricles, causing the ventricles to contract. (interactive-biology.com)
We have a stimulus that comes from the AV node or the SA node and that spreads to the muscle cells. (interactive-biology.com)
Not the least of these exceptional properties is its ability to initiate an electrical potential at a fixed rate that spreads rapidly from cell to cell to trigger the contractile mechanism. (lumenlearning.com)

ZF activators, or ZF-As, are created by attaching a zinc finger array to an activation domain with the aim of increasing the expression of a target gene relative to an untreated cell. (sangamo.com)
Here, we generated iPSCs from a Chinese patient with 49-50 exons deletion in DMD gene by reprogramming peripheral blood mononuclear cells with non-integrating vectors. (hpscreg.eu)

Anatomy55

Organisms18

Diseases31

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes53

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena2

Information Science3

Health Care4

Contraction16

Myocytes6

Tissues17

Myocardium6

Tissue30

Membrane potential3

Myocardial infarction1

Junctions6

Conduction6

Electrical impulses1

Arrhythmia2

Impulses2

Neurons6

Endothelial cells3

Skeletal muscles6

Mesoderm6

Atrial1

Mutations3

Repolarization3

Differentiation9

Proteins8

Myofibrils2

Progenitors2

Weakness2

Sarcoplasmic reticulum1

Action potentials2

Ventricular3

Branchiomeric muscle1

Oxidative stress3

Epithelium1

Aerobic respiration2

Isoforms5

Serious cardiac1

20231

Normal cardiac1

Sarcomeres4

Fibroblasts5

Adjacent2

Heart's1

Abnormalities3

Researchers3

Mitochondrial4

Vertebrates2

Signal Transduction1

Macrophages7

Function8

Biology3

Pluripotent4

Involuntary1

Embryonic2

Developmental3

Heart18

Differentiate2

Undergo2

Myosin2

Myoblasts1

Regenerative5

Cardiovascular1

Progenitor cells1

Myopathy2

Nuclei2

Stem6

Venous2

Spreads3

Gene2