• Testicular and paratesticular neoplasms in prepubertal males. (medscape.com)
  • Tallen G, Hernáiz Driever P, Degenhardt P, Henze G, Riebel T. High reliability of scrotal ultrasonography in the management of childhood primary testicular neoplasms. (medscape.com)
  • Unlike germ cell tumors of the testicles, this tumor does not seem to be linked to undescended testes . (medlineplus.gov)
  • Leydig cell tumors make up a very small number of all testicular tumors. (medlineplus.gov)
  • As Leydig cell tumors are rare, these treatments have not been studied as much as treatments for other, more common testicular cancers. (medlineplus.gov)
  • 1 Zagreb University Hospital Centre, Department of Oncology, Division of Medical Oncology, Unit of Uro-oncology, Referral Center for Treatment of Germ Cell Tumors and Extragonadal Germ Cell Tumors of the Ministry of Health of the Republic of Croatia, Zagreb, Croatia. (nih.gov)
  • Testicular germ cell tumors make up 0.5% of pediatric malignancies, and 14% of adolescent malignancies. (urotoday.com)
  • Since the discovery of platinum-based chemotherapy, testicular germ cell tumors are a highly curable disease. (urotoday.com)
  • The further development of CIS into invasive germ cell tumors may depend on signals from their postpubertal niche of somatic cells, including hormones and growth factors from Leydig and Sertoli cells. (ku.dk)
  • Adenomatoid tumors represent 30% of the tumors of the testicular adnexa and 60% of benign tumors of these structures. (medscape.com)
  • on rare occasions, it may extend to the testicular parenchyma (most often tumors of the upper pole). (medscape.com)
  • 2003) Histology and clinical outcomes in patients with bilateral testicular germ cell tumors: the Memorial Sloan Kettering Cancer Center experience 1950 to 2001. (medscape.com)
  • 2002) Bilateral testicular germ cell tumors. (medscape.com)
  • 2005) Management and outcome of bilateral testicular germ cell tumors: twenty-five year experience in Munich. (medscape.com)
  • 1988) Simultaneous bilateral testicular germ cell tumors with dissimilar histology: case report and review of the literature. (medscape.com)
  • Weissbach L (1995) Organ preserving surgery of malignant germ cell tumors. (medscape.com)
  • 1995) A conservative approach to bilateral testicular germ cell tumors. (medscape.com)
  • An experienced care team is very important for treating testicular cancer (germ cell tumors). (mskcc.org)
  • However, three additional histologies (thyroid carcinoma, melanoma, and testicular cancer) with incidences of more than 2 cases per 1 million people were also included in the very rare group because there is a lack of knowledge and expertise in the management of these tumors. (cancer.gov)
  • A novel mouse model of testicular granulosa cell tumors. (tamu.edu)
  • SUMMARY ANSWER: Overactivation of TGFB signaling results in the development of testicular tumors resembling granulosa cell tumors (GrCTs). (tamu.edu)
  • We further investigated the molecular features of testicular tumors and determined the expression of beta-catenin (CTNNB1) known to be involved in testicular GrCT development. (tamu.edu)
  • Childhood extracranial germ cell tumors form from germ cells in parts of the body other than the brain. (cigna.com)
  • This summary is about germ cell tumors that form in parts of the body that are extracranial (outside the brain). (cigna.com)
  • Extracranial germ cell tumors are most common in adolescents, with rates in this age group lower for females than males. (cigna.com)
  • For information on intracranial (inside the brain) germ cell tumors, see Childhood Central Nervous System Germ Cell Tumors Treatment. (cigna.com)
  • Childhood extracranial germ cell tumors may be benign or malignant. (cigna.com)
  • Childhood extracranial germ cell tumors are grouped as gonadal or extragonadal extracranial tumors. (cigna.com)
  • Malignant extracranial germ cell tumors are tumors that form outside the brain. (cigna.com)
  • Gonadal germ cell tumors form in the gonads (testicles and ovaries). (cigna.com)
  • Testicular germ cell tumors are divided into two main types, seminoma and nonseminoma. (cigna.com)
  • Testicular germ cell tumors usually occur before the age of 4 years or in adolescents and young adults. (cigna.com)
  • Testicular germ cell tumors in adolescents (11 years and older) and young adults are different from those that form in early childhood. (cigna.com)
  • Ovarian germ cell tumors are more common in adolescent girls and young women. (cigna.com)
  • Most ovarian germ cell tumors are benign mature teratomas (dermoid cysts). (cigna.com)
  • Extragonadal extracranial germ cell tumors form in areas of the body other than the brain or gonads (testicles and ovaries). (cigna.com)
  • Most extragonadal extracranial germ cell tumors form along the midline of the body. (cigna.com)
  • In children younger than 11 years, extragonadal extracranial germ cell tumors usually occur at birth or in early childhood. (cigna.com)
  • In older children, adolescents, and young adults (11 years and older), extragonadal extracranial germ cell tumors are often in the mediastinum. (cigna.com)
  • Treg and Tfh cells were most frequently detected in tumors, along with helper (CD4+) and cytotoxic (CD8+) T cells. (uni-giessen.de)
  • However, a recently available hypothesis associated with the genesis of testicular tumors and indicating the neoplastic cells, which retain stem cell features, as the roots of testicular tumors, continues to be reported [7]. (scienceexhibitions.org)
  • Germ cell tumors happens as combined tumors, which take into account about 60% of situations, and consist of a combined mix of non-seminomatous and seminomatous components, with several histological subtypes that are and arbitrarily distributed through the entire tumor [4 variably, 5]. (scienceexhibitions.org)
  • Exceedingly Rare Bilateral Synchronous Germ Cell Testicular Tumors Wit" by Jong H. Kim, Ray D. Page et al. (hcahealthcare.com)
  • Bilateral synchronous testicular tumors are a relatively uncommon occurrence, especially when they involve germ cell tumors of different histology. (hcahealthcare.com)
  • In this context, we present a compelling case report of a male patient who was diagnosed with bilateral synchronous germ cell testicular tumors, with one being a seminoma and the other a non-seminomatous germ cell tumor (NSGCT). (hcahealthcare.com)
  • By highlighting this unique case, we aim to underscore the significance of meticulous evaluation and accurate diagnosis when confronted with bilateral synchronous testicular tumors of different histology. (hcahealthcare.com)
  • Testicular germ cell tumors (TGCT), evenly divided into two histologic types, seminomas and nonseminomas, are the most common malignancy among males between ages 15 to 44 years [1, 2]. (utrgv.edu)
  • The two main types of stromal tumors are Leydig cell tumors and Sertoli cell tumors. (mountsinai.org)
  • Bilateral Testicular Germ Cell Tumors: A Case-Series From a UK-Based Tertiary Referral Center Over 19 Years. (ox.ac.uk)
  • Pediatric testicular tumors: contemporary incidence and efficacy of testicular preserving surgery. (medscape.com)
  • Juvenile granulosa cell tumors of the testis: a clinicopathologic study of 70 cases with emphasis on its wide morphologic spectrum. (medscape.com)
  • Racial differences among boys with testicular germ cell tumors in the United States. (medscape.com)
  • Risk stratification of pubertal children and postpubertal adolescents with clinical stage I testicular nonseminomatous germ cell tumors. (medscape.com)
  • Prepubertal testicular tumors: a 20-year experience with 40 cases. (medscape.com)
  • It usually develops in this age group (median age ~65 years old, range 10-96 years) and presents as a painless testicular mass or swelling in one testis or, in ~6% of cases, both testes: PT-DLBCL is the most common testicular cancer to present with disease in both testicles. (wikipedia.org)
  • Testicular germ cell cancers in young adult men derive from a precursor lesion called carcinoma in situ (CIS) of the testis. (ku.dk)
  • Our data are in line with the idea that CIS cells may be gonocytes that survived in the postnatal testis. (ku.dk)
  • We speculate that disturbed development of somatic cells in the fetal testis may play a role in allowing undifferentiated cells to survive in the postnatal testes. (ku.dk)
  • 1. Isolated germ cells from the testis were divided by Ficoll density gradient centrifugation into the following 3 cell type fractions : the primary spermatocytes together with spermatogonia, secondary spermatocytes and spermatids. (nii.ac.jp)
  • Guidelines for the Implementation of a Testis-sparing Approach to Testicular Cancer. (medscape.com)
  • So far there has been no comprehensive review using systematic literature search strategies to show the application of single-cell RNA sequencing (scRNA-seq) in the human testis of the whole life cycle (from embryos to aging males). (ijbs.com)
  • Although a high level of PDE10A gene expression is observed in the testis, information on the identity of the isoforms or on the cell type that express the PDE10 protein is lacking. (plos.org)
  • The objective of this study was to identify the PDE10A isoforms expressed in the testis and germ cells, and to determine the presence and localization of PDE10A in mature spermatozoa. (plos.org)
  • Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia. (nih.gov)
  • Adult-type granulosa cell tumor of the testis: report of a case and review of literature. (nih.gov)
  • Granulosa cell tumor of testis: clinicopathological correlation of a rare tumor. (nih.gov)
  • Congenital juvenile granulosa cell tumor of the testis in newborns. (nih.gov)
  • Juvenile granulosa cell tumor of the testis. (nih.gov)
  • MSCs with 3 × 10 4 cells were locally injected into left testis 30 min before detorsion. (biomedcentral.com)
  • MSCs significantly reversed the imbalance of glycolysis in sperm and testis induced by testicular torsion-detorsion, as evidenced by increasing the expression of phosphoglycerate kinase 2 and glyceraldehyde-3-phosphate dehydrogenase-spermatogenic, activating Akt, and increasing glycogen synthase kinase 3 (GSK3), which led to the increase in glycolysis cascades and ATP production. (biomedcentral.com)
  • Local injection of MSCs into a testis damaged by testicular torsion-detorsion restores sperm function mainly through the improvement of sperm motility and energy. (biomedcentral.com)
  • In our series studies, animal model with severe cell necrosis in testis was created by a 720° testicular torsion for 3 h. (biomedcentral.com)
  • In these studies, the differentiation capacities of MSCs, obtained from diverse sources, to male germ cells were determined in vitro and their effects on testis niche were assessed by injection of MSCs into the testis. (jsurgmed.com)
  • The effect of constitutively active TGFBR1 on testis development and the timeline of testicular tumor formation were examined. (tamu.edu)
  • Background: T-cell lymphomas involve the testis infrequently, which deserve special attention because of the poor prognosis and the need to make an appropriate diagnosis, which could lead to a better therapeutic strategy.Case presentation: A 40-year-old man presented with right testicular swelling for past three months. (aku.edu)
  • As an immune-privileged organ, the normal testis immune environment consists of macrophages, mast cells and few T cells, all having anti-inflammatory effects to protect developing germ cells from autoimmune attack. (uni-giessen.de)
  • In summary, despite high inter-individual variation and sample heterogeneity, all study approaches showed a similar composition of immune cells in the human testis, with an overall increase of immune cells in TGCT compared to other pathological conditions and normal controls. (uni-giessen.de)
  • We investigated the role of occupational HMs and WFs exposures on the risk of testicular germ cell tumours (TGCT) in the TESTIS study. (who.int)
  • The testis is an important target for PAHs, yet insufficient attention has been paid to their effects on steroidogenesis in Leydig cells. (johnshopkins.edu)
  • Testicular biopsy is indicated in azoospermic men with a normal-sized testis and normal findings on hormonal studies to evaluate for ductal obstruction, to further evaluate idiopathic infertility, and to retrieve sperm. (medscape.com)
  • Testicular Torsion Testicular torsion is the twisting of a testis on its spermatic cord so that the blood supply to the testis is blocked. (msdmanuals.com)
  • Because of advances in diagnostic procedures, sophisticated radiation techniques and especially the introduction of cisplatin based chemotherapy protocols together with advanced postchemotherapy surgical techniques, curability is expected in about 95% of all patients diagnosed with testicular cancer and over 70% of patients with advanced disease. (nih.gov)
  • Imaging of testicular germ cell tumours. (qxmd.com)
  • This article reviews the role of imaging of testicular germ cell tumours. (qxmd.com)
  • 2006) Management of bilateral testicular germ cell tumours-experience of the German Testicular Cancer Study Group (GTCSC) [abstract]. (medscape.com)
  • Management and outcome of paediatric testicular tumours - A 20 year experience. (nih.gov)
  • Prepubertal testicular tumours and efficacy of testicular preserving surgery. (nih.gov)
  • AimsTo evaluate if a deep learning algorithm can be trained to identify tumour-infiltrating lymphocytes (TILs) in tissue samples of testicular germ cell tumours and to assess whether the TIL counts correlate with relapse status of the patient.MethodsTILs were manually annotated in 259 tumour regions from 28 whole-slide images (WSIs) of H&E-stained tissue samples. (ox.ac.uk)
  • Even after effectively treating testicular cancer in one testicle, about 3% to 4% of people will develop it in their other testicle. (healthline.com)
  • 2005) Risk-adapted management for patients with clinical stage I seminoma: the second Spanish Germ Cell Cancer Cooperative Group Study. (medscape.com)
  • A higher TIL density was associated with a lower clinical tumour stage, seminoma histology and lack of lymphovascular invasion.ConclusionsDeep learning-based image analysis can be used for detecting TILs in testicular germ cell cancer more objectively and it has potential for use as a prognostic marker for disease relapse. (ox.ac.uk)
  • The patient underwent orchidectomy, and based on histopathological and immunohistochemical tests, a peripheral T-cell lymphoma, not otherwise specified was diagnosed.Conclusion: Testicular peripheral T-cell lymphomas are rare and aggressive cancers, with clinical differentials of seminoma and non-neoplastic conditions. (aku.edu)
  • This study provides a detailed analysis of TIL focusing on Treg and Tfh in human testicular specimens characterized by hypospermatogenesis and lymphocytic infiltrates (ly) (n=12), pre-invasive germ cell neoplasia in situ (GCNIS -/+ly) (n=15, each), and seminoma (n=28) compared to normal spermatogenesis (n=10). (uni-giessen.de)
  • The tumor-node-metastasis (TNM) classification for seminoma testicular cancer is provided below. (medscape.com)
  • Seminoma: This is a slow-growing form of testicular cancer found in men in their 40s and 50s. (mountsinai.org)
  • The cells can be seminoma, nonseminoma, or both. (mountsinai.org)
  • Testicular torsion is an urological emergency that may lead to infertility due to ischemic injury. (biomedcentral.com)
  • We previously reported that mesenchymal stem cells (MSCs), through local injection upon testicular torsion-detorsion, restored the spermatogenesis without differentiation into sperm. (biomedcentral.com)
  • In this study, molecular mechanisms of MSCs in regulating germ cell activity induced by testicular torsion-detorsion were investigated. (biomedcentral.com)
  • Right inguinal skin incision without testicular torsion served as control. (biomedcentral.com)
  • Testicular torsion-detorsion significantly decreased the amount of sperm, inhibited the motility, declined the F-actin expression, and reduced the content of ATP in sperm. (biomedcentral.com)
  • With MSCs, ATP content and F-actin were preserved after testicular torsion-detorsion. (biomedcentral.com)
  • Human stem cell factor contributed the activation of Akt/GSK3 axis when sperm suffered from testicular torsion-detorsion-induced germ cell injury. (biomedcentral.com)
  • Testicular torsion is an urology emergency and which threats 1/4000 of male population younger than 25 years old with infertility as a sequela of germ cell ischemic/reperfusion (I/R) injury [ 1 ]. (biomedcentral.com)
  • Duration of testicular torsion and the severity of cord twisting are two key prognostic factors for sperm survival and activity. (biomedcentral.com)
  • However, in a cord twisting higher than 360° plus symptom duration more than 24 h, complete or severe testicular atrophy is inevitable due to cell necrosis starting from 4 h after testicular torsion. (biomedcentral.com)
  • We previously explored that local injection of mesenchymal stem cells (MSCs) 30 min before surgical detorsion was applicable to prevent testicular torsion-induced I/R injury on germ cell and maintain the spermatogenesis at acute stage. (biomedcentral.com)
  • Non-obstructive azoospermia may occur due to genetic factors, exposure to toxic substances, anticancer treatments such as radiotherapy and chemotherapy and testicular torsion. (jsurgmed.com)
  • Secondary hydroceles are caused by conditions such as inflammation, infection, previous surgeries, or testicular torsion. (medscape.com)
  • Noncommunicating hydroceles can also be congenital, or they may result from conditions such as inflammation, infection, previous surgeries, or testicular torsion. (medscape.com)
  • Testicular torsion causes sudden, severe pain and later swelling of the. (msdmanuals.com)
  • Piperine stimulates pubertal Leydig cell development by increasing Leydig cell number and promoting its maturation while it inhibits spermatogenesis in the rat. (frontiersin.org)
  • In order to examine whether PIP affected spermatogenesis by interfering with Leydig cell testosterone production, in the current study we evaluated the effects of PIP on pubertal Leydig cell development. (frontiersin.org)
  • MSC-secreted stem cell factor (SCF) played a role in promoting spermatogenesis in the recipient [ 2 ]. (biomedcentral.com)
  • Cross section of human testicular cells 3D printed into a tubular structure. (ubc.ca)
  • In a pair of world firsts, UBC scientists have 3D printed human testicular cells and identified promising early signs of sperm-producing capabilities. (ubc.ca)
  • Here, we summarized the application of scRNA-seq analyses on various human testicular biological samples. (ijbs.com)
  • ScRNA-seq has been widely used on different human testicular samples with various library strategies, and new cell subtypes such as State 0 spermatogonial stem cells (SSC) and stage_a/b/c Sertoli cells (SC) were identified. (ijbs.com)
  • Chen, X.F. Application of single-cell RNA sequencing on human testicular samples: a comprehensive review. (ijbs.com)
  • Using single-cell RNA sequencing (RNAseq), we studied the development of ProSG, their SG descendants and testicular somatic cells during the perinatal period in mice. (biologists.com)
  • For the development of normal testes, scRNA-seq-based evidence showed dynamic transcriptional changes of both germ cells and somatic cells from embryos to adults. (ijbs.com)
  • As in somatic cells, sperm intracellular cAMP concentration is regulated by the opposite action of two enzymes: the adenylyl cyclases (AC), which synthesize cAMP from ATP, and the phosphodiesterases (PDE), which break the phosphodiester bond of cAMP to form 5'-adenosine monophosphate (AMP). (plos.org)
  • WHAT IS KNOWN ALREADY: In an earlier study, we demonstrated that constitutively active TGFB receptor 1 (TGFBR1) in ovarian somatic cells promotes the development of ovarian GrCTs. (tamu.edu)
  • Testicular cancer is one of the most treatable and curable cancers. (medlineplus.gov)
  • In fact, this is more common in testicular cancer than in several other cancers, including breast cancer. (healthline.com)
  • resemble to primordial germ cells (PGCs) and/or the cells in the CIS, producing TGCTs an interesting model for check out germ and gametogenesis cell advancement in both normal and cancers systems. (scienceexhibitions.org)
  • These cancers grow from germ cells, the cells that make sperm. (mountsinai.org)
  • Who is most likely to develop testicular cancer? (medlineplus.gov)
  • Even so, many people who develop testicular cancer don't have a family history. (healthline.com)
  • But that doesn't mean you'll develop testicular cancer. (healthline.com)
  • About 1 in 250 people assigned male at birth may develop testicular cancer. (healthline.com)
  • 1995) Bilateral synchronous testicular germ cell cancer. (medscape.com)
  • Spontaneous regression of metastatic testicular carcinoma in a patient with bilateral sequential testicular tumor. (greenmedinfo.com)
  • Maternal smoking in pregnancy may increase the risk of testicular germ cell cancer (TGCC) in offspring, but current evidence remains inconclusive. (lu.se)
  • If a parent carries a gene that may increase the risk of testicular cancer , it's possible they could pass it down to you. (healthline.com)
  • Keep reading to discover how your genetics can influence your risk of testicular cancer, what other factors play a role, and what you can do to lower your risk. (healthline.com)
  • According to a 2019 research review , your risk of testicular cancer might be four to six times higher if a parent had the disease. (healthline.com)
  • Who's at risk of testicular cancer? (healthline.com)
  • While family history may significantly increase your risk of testicular cancer, other risk factors play a role. (healthline.com)
  • Having an undescended testicle (cryptorchidism) may increase your risk of testicular by almost nine times . (healthline.com)
  • Instead, another health condition could increase your risk of testicular cancer and cryptorchidism. (healthline.com)
  • According to 2019 research , only two viruses tend to have a link to an increased risk of testicular cancer: HIV and Epstein-Barr virus . (healthline.com)
  • These data indicate that, through the spatiotemporal pattern of PDGF ligands and receptors expression, PDGF may play a role in testicular development and homeostasis. (rupress.org)
  • High-dose chemotherapy with stem cell transplant . (medlineplus.gov)
  • Genome-wide association study of cardiovascular disease in testicular cancer patients treated with platinum-based chemotherapy. (cdc.gov)
  • However, we did not observe serious testicular atrophy or azoospermia, although spermatogonial apoptosis was significantly increased. (johnshopkins.edu)
  • It has been associated with testicular atrophy, leukopenia, and necrosis of the thymus. (cdc.gov)
  • Primary testicular diffuse large B-cell lymphoma (PT-DLBCL), also termed testicular diffuse large B-cell lymphoma and diffuse large B-cell lymphoma of the testes, is a variant of the diffuse large B-cell lymphomas (DLBCL). (wikipedia.org)
  • Lymphomas that begin in the testes, i.e. primary testicular lymphomas (PTL), are rare forms of lymphoma that represent 1-2% of all non-Hodgkins lymphomas and 5% of all testicular malignancies. (wikipedia.org)
  • Testicular dynamics parameters recorded in both testes and caudae epididymides were found to be increased only in Orchis anatolica treated mice. (degruyter.com)
  • In addition, it became clear that the predominance of resident macrophages in normal testes is shifted in favor of T cells as the main component of TIL in TGCT. (uni-giessen.de)
  • And lipid peroxidation and ferritin accumulation were found to be significantly increased in Leydig cells of testes with a PM2.5- dose dependent manner. (bvsalud.org)
  • A Leydig cell tumor is a tumor of the testicle. (medlineplus.gov)
  • It must be the 'extensive intersitial involvement by dispersed tumor cells' all through the testicle that is leading this dr to conclude that the tumor is biiger than 7mm. (testicularcancersociety.org)
  • A tissue sample from the testicle is viewed under a microscope to check for cancer cells. (medlineplus.gov)
  • If testicular cancer does develop, it's usually in the testicle that didn't descend. (healthline.com)
  • This suggests that an undescended testicle doesn't cause you to have testicular cancer. (healthline.com)
  • Testicular ultrasound showed diffuse increase in size of the testicle, with alteration in its echogenicity. (aku.edu)
  • Subsequent clinical history and physical exam of the patient revealed a right testicular solid mass measuring 13.3 x 7.8 x 10.7 cm. (utrgv.edu)
  • Patient was aware of this progressively enlarging right testicular mass for the past 5-years, but had not undergone previous evaluation. (utrgv.edu)
  • Nonseminoma: This more common type of testicular cancer tends to grow more quickly than seminomas. (mountsinai.org)
  • Spontaneous regression of pulmonary metastases from testicular embryonal carcinoma. (greenmedinfo.com)
  • Vinyl-cyclohexene-dioxide also inhibits the growth of Walker cell carcinoma in rats. (cdc.gov)
  • There is no germ cell neoplasia-in-situ in the surrounding testicular parenchyma. (webpathology.com)
  • Testicular germ cell apoptosis and formation of th. (ifce.fr)
  • The therapeutic effect of MSCs came from paracrine effect to inhibit testicular apoptosis, reduce intra-testicular oxidative stress, and maintain serum testosterone level. (biomedcentral.com)
  • Testicular cancer incidence rate has risen globally over the past several decades, with the average increase in the incidence of testicular cancer in Croatia of 7% per annum from the year 1983 to 2007. (nih.gov)
  • Testicular germ cell tumor (TGCT) incidence has increased over the last 40 years in the United States. (nih.gov)
  • 1999) Incidence of testicular cancer in the United States: has the epidemic begun to abate? (medscape.com)
  • Testicular cancer is the most frequent malignancy in young men in industrialized countries with an increasing incidence, and its aetiology remains largely unknown. (who.int)
  • Using immunohistochemistry (IHC), T cells were confirmed as most abundant TIL, with Treg and Tfh cells most frequently observed in seminomas. (uni-giessen.de)
  • Consistent with IHC, T cells were most abundant in seminomas. (uni-giessen.de)
  • A case of spontaneous regression of metastatic testicular teratoma. (greenmedinfo.com)
  • Final diagnosis was "Stage IIIA-Testicular GCT-Low-risk" based on the primary and metastatic sites involvement and serum tumor marker levels. (utrgv.edu)
  • T cells represent the major component of tumor infiltrating lymphocytes (TIL) in TGCT. (uni-giessen.de)
  • Potential roles of rarer subtypes, such as regulatory (Treg) and follicular helper T (Tfh) cells, being associated with tumor biology in other cancer entities, have not been investigated in TGCT. (uni-giessen.de)
  • Again, T cells were the most prominent TIL in TGCT. (uni-giessen.de)
  • In addition, the interaction between BCL6 and NANOG might control Tfh cell recruitment in TGCT, and the cooperation between CXCR3 and ICOS is likely to be important for their functionality. (uni-giessen.de)
  • This study has described the complexity of TIL in TGCT and provides first indications that rarer T cell subtypes and their signaling molecules are likely to be of functional importance in the TGCT immune environment. (uni-giessen.de)
  • were estimated using conditional logistic regression models adjusted for sibship size, being born from multiple pregnancies, personal history of testicular trauma, family history of TGCT, family history of cryptorchidism and exposure to solvents. (who.int)
  • Immunohistochemical stains revealed positive pancytokeratin and SALL4, a transcription factor specific for embryonic cell pluripotency and an immunohistochemical marker for TGCT [7]. (utrgv.edu)
  • Guideline] NCCN Clinical Practice Guidelines in Oncology: Testicular Cancer. (medscape.com)
  • NCCN Clinical Practice Guidelines in Oncology: Testicular Cancer. (medscape.com)
  • It develops from Leydig cells. (medlineplus.gov)
  • For in vitro studies, immature Leydig cells were isolated from 35-day-old male rats and treated with 50 μM piperine in the presence of different steroidogenic stimulators/substrates for 24 h. (frontiersin.org)
  • Piperine in vitro also increased androgen production and stimulated cholesterol side-chain cleavage enzyme and 17α-hydroxylase/20-lyase activities in immature Leydig cells. (frontiersin.org)
  • Late-stage pubertal development of Leydig cells is mainly involved in the transition of immature Leydig cells to adult Leydig cells. (frontiersin.org)
  • The predominant cell population expressing transcripts of the PDGFs and PDGFRs genes during prenatal and early postnatal periods were Sertoli cells and peritubular myoid cells (PMC) or their precursors, respectively, while in adult animals PDGFs and PDGFRs were confined in Leydig cells. (rupress.org)
  • And dysregulated metabolic signaling or hedgehog signaling were revealed by scRNA-seq in aged SC or Leydig cells (LC), respectively. (ijbs.com)
  • The current studies indicate that Leydig cells from old (24-27-Mo) rats secreted significantly less cholesterol in response to stimulators, hCG, forskolin, or Bt2cAMP as compared to cells from young mature (5-Mo) animals. (benthamopen.com)
  • Intestinal testicular Leydig cells and germinal cells counts were elevated significantly in mice treated with Orchis anatolica plant when compared with the other two groups. (degruyter.com)
  • Mechanically, PM2.5-induced FDX1 upregulation resulted in cellular ROS elevation and ferrous iron overload , which together initiated an autoxidation process of polyunsaturated fatty acids in the cell membrane of Leydig cells until the accumulated lipid peroxides triggered ferroptotic cell death . (bvsalud.org)
  • In summary, our work suggested that FDX1, a mediator involving steroidogenesis, was a key regulator in PM2.5-induced Leydig cells ferroptosis . (bvsalud.org)
  • Objective: We hypothesized that long-term exposure to low concentrations of B[a]P might disrupt testosterone production in Leydig cells via an alteration of steroidogenic proteins. (johnshopkins.edu)
  • Compared with control cells, Leydig cells primed with B[a]P in vivo produced less testosterone in response to human chorionic gonadotropin (hCG) or dibutyl cyclic adenosine monophosphate in vitro. (johnshopkins.edu)
  • Of note, the reduction of testosterone levels was accompanied by decreased expression of steroidogenic acute regulatory protein (StAR) and 3β-hydroxysteroid dehydrogenase (3β-HSD), as well as increased levels of cytochrome P450 side chain cleavage (P450scc), in Leydig cells. (johnshopkins.edu)
  • however, adolescent histology is mostly mixed nonseminomatous germ cell tumor. (urotoday.com)
  • Not only that, they had matured into several of the specialized cells involved in sperm production and were showing a significant improvement in spermatogonial stem cell maintenance - both early signs of sperm producing capabilities. (ubc.ca)
  • This intermediate (I)-ProSG subset translocates from the center of seminiferous tubules to the spermatogonial stem cell (SSC) 'niche' in its periphery soon after birth. (biologists.com)
  • 3 - 5 This report by the Spanish Lymphoma Group (GELTAMO) aims to provide useful guidelines and recommendations for the prevention, diagnosis, and treatment of central nervous system diffuse large B-cell lymphoma patients with, or at risk of, leptomeningeal and/or brain parenchyma lymphoma relapse. (haematologica.org)
  • 4. From above-mentioned results, it was concluded that in spermatogonia and spermatocytes of the sea urchin, duplication of the centriole takes place in association with flagellum growth, and then each paired centriole changes its function to form the cell division centers. (nii.ac.jp)
  • DLBCL are a large and diverse group of B-cell malignancies with the great majority (-85%) being typed as diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS). (wikipedia.org)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • What are the treatments for testicular cancer? (medlineplus.gov)
  • Oddly enough, despite differences within their particular cell of origins, TGCTs Mocetinostat cost talk about the beneficial feature to be curable extremely, because of their outstanding responsiveness to healing treatments [8]. (scienceexhibitions.org)
  • For the recent study, the researchers performed a biopsy to collect stem cells from the testicles of a patient living with NOA. (ubc.ca)
  • The expression profile of CIS cells was compared with microdissected gonocytes, oogonia, and cultured embryonic stem cells with and without genomic aberrations. (ku.dk)
  • We did not find indications that CIS was derived from a meiotic cell, and the similarity to embryonic stem cells was modest compared with gonocytes. (ku.dk)
  • Can mesenchymal stem cells ameliorate testicular damage? (jsurgmed.com)
  • Many recent studies have demonstrated the therapeutic effects of mesenchymal stem cells (MSC) in different disease models. (jsurgmed.com)
  • Human induced pluripotent stem cells and male infertility: an overview of current progress and perspectives. (jsurgmed.com)
  • Transmission has also been reported through blood products by mucocutaneous contact or needlestick injury during patient care or laboratory work ( 7 , 8 ) and by blood transfusion ( 9 , 10 ) or organ ( 11 ) or blood stem cell ( 12 ) transplants. (cdc.gov)
  • We also molecularly defined the development of Sertoli, Leydig and peritubular myoid cells during the perinatal period, allowing us to identify candidate signaling pathways acting between somatic and germ cells in a stage-specific manner during the perinatal period. (biologists.com)
  • We also found that early postnatal Sertoli cells produce PDGF-like substances and that this production is inhibited dose dependently by follicle-stimulating hormone (FSH). (rupress.org)
  • The expression of PDGFRs by PMC and of PDGFs by Sertoli cells corresponds in temporal sequence to the developmental period of PMC proliferation and migration from the interstitium to the peritubulum. (rupress.org)
  • Moreover, we observed that all the PDGF isoforms and the medium conditioned by early postnatal Sertoli cells show a strong chemotactic activity for PMC which is inhibited by anti-PDGF antibodies. (rupress.org)
  • DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry. (nih.gov)
  • Gynandroblastoma with elements resembling juvenile granulosa cell tumor. (nih.gov)
  • Ultrasonogram in an infant revealing a heterogeneous intratesticular mass that proved to be a juvenile granulosa-cell tumor. (medscape.com)
  • The B-cells in PT-DLBCL are malignant lymphocytes that normally function in the humoral immunity component of the adaptive immune system by secreting antibodies that, for example, bind to and neutralize invasive pathogens. (wikipedia.org)
  • Germ-cell testicular cancer (GCTC) is a malignant neoplasm derived from the primordial germ cell. (nih.gov)
  • In the presence of any painless hard Scrotal mass it looks reasonable to considered malignant until proven otherwise, we present a case about a young man with multiple hard scrotal masses of spindle cells for more than one year that it increased in size and number by the time which is a very rare tumor in the scrotal. (clinicofsurgery.org)
  • Microscopic examination of the biopsy revealed solid nests of infiltrative malignant epitheloid cells characterized by nuclear pleomorphisms and hyperchromatic nuclei with focal necrotic and apoptotic debris. (utrgv.edu)
  • Dell'atti reported a case diagnosed with testicular ultrasound. (medscape.com)
  • Furthermore, our results supported that the ferroptosis of TM-3 cells was attributed to the upregulation of ferredoxin 1 (FDX1), which was the protein transferring electrons to cytochrome P450 family 11 subfamily A member 1 to aid lysing cholesterol to pregnenolone at initial of steroidogenesis. (bvsalud.org)
  • These are the cells in the testicles that release the male hormone, testosterone . (medlineplus.gov)
  • Testicular cancer is a cancer that develops in the tissues of one or both testicles. (medlineplus.gov)
  • These cells later become sperm in the testicles or eggs in the ovaries. (cigna.com)
  • Testicular cancer is cancer that starts in the testicles. (mountsinai.org)
  • Familial aggregation of testicular cancer among early-onset cancer survivors. (cdc.gov)
  • Following intravenous bolus administration of 30 units of bleomycin to one patient with a primary germ cell tumor of the brain, a peak CSF level was 40% of the simultaneously-obtained plasma level and was attained in two hours after drug administration. (nih.gov)
  • 2006) Value of frozen section analysis with suspected testicular malignancy. (medscape.com)
  • Cancer Risk in Relatives of Testicular Cancer Patients by Histology Type and Age at Diagnosis: A Joint Study from Five Nordic Countries. (cdc.gov)
  • Potential role of reactive oxygen species on testicular pathology associated with infertility. (jsurgmed.com)
  • Therefore, TGCTs, by representing an exclusive pathology at a cross-road in neoplastic and developmental procedures, not merely constitute something for learning the system of change of totipotent cells and their capacity to differentiate into distinctive germ lines but also a problem for their remarkable molecular (hereditary and epigenetic) features, in charge of their extraordinary awareness to chemotherapeutic medications. (scienceexhibitions.org)
  • The evaluation of the growth pattern and pubertal development of a group of patients with sickle-cell anaemia from childhood to adulthood. (bvsalud.org)
  • Additionally, the neoplastic B-cells in this disease acquire abnormalities in their expression of certain genes that further allow them to escape immune responses. (wikipedia.org)
  • In testicular germ cell tumour (GCT), imaging plays a central role in assessment of tumour bulk, sites of metastases, monitoring response to therapy, surgical planning and accurate assessment of disease at relapse. (qxmd.com)
  • Each year, MSK's testicular cancer care team sees about 500 people newly diagnosed with this disease. (mskcc.org)
  • I know TC is the most powerfull testicular disease ever made and I really gotta ask myself if I'm a punk. (testicularcancersociety.org)
  • Non-neoplastic smoke-related lung disease: chronic obstructive pulmonary disease, small airways disease/respiratory bronchiolitis, Langerhans cell histiocytosis of the lung. (unibo.it)
  • We're 3D printing these cells into a very specific structure that mimics human anatomy, which we think is our best shot at stimulating sperm production. (ubc.ca)
  • The cells were then grown and 3D printed onto a petri dish into a hollow tubular structure that resembles the sperm-producing seminiferous tubules. (ubc.ca)
  • The team is now working to "coach" the printed cells into producing sperm. (ubc.ca)
  • If they can get the cells to produce sperm, those sperm could potentially be used to fertilize an egg by in vitro fertilization, providing a new fertility treatment option for couples. (ubc.ca)
  • Human sperm cell is a flagellate cell consisting of a disc-shaped head and a long tail released from the seminiferous tubule and mature in the epididymis. (biomedcentral.com)
  • Prevalence of pathogenic germline cancer risk variants in testicular cancer patients: Identifying high risk groups. (cdc.gov)
  • Thirty patients with sickle-cell anaemia (mean age= 13.93 years) were evaluated at Te1 and 26 patients (mean age = 25.08 years) at Te3. (bvsalud.org)
  • Patients with sickle-cell anaemia showed growth impairment and pubertal delay compared with healthy controls. (bvsalud.org)