• According to data from the Mexican Institute of Geography and Statistics (INEGI) in 2012, from every hundred women over the age of 20 who died of malignant tumors, 15 were from breast cancer. (news-medical.net)
  • Clear-cell myomelanocytic tumors (CCMT) of the perivascular epithelioid cell tumor (PEComa) family have been recently reported. (nih.gov)
  • Mesenchymal tumors include structures arising from mesodermal-derived precursor cells that develop into cartilage, bone, or other connective tissues. (newhopemedicalcenter.com)
  • The goal of our alternative treatments for granular cell tumors is to stimulate the spontaneous regression of cancer cells and ultimately light your path toward remission. (newhopemedicalcenter.com)
  • In the malignant tumors, both proliferation activity and expression of the telomerase-associated RNA significantly increased. (nih.gov)
  • T-16HBE-C1?5 cells can form tumors subcutaneously in nude mice. (eurekamag.com)
  • Histopathological changes in the tumors indicated nests growth, high nuclear-cytoplasmic ratios, coarse and clumped chromatin, numerous and distinctly atypical mitoses, cell necrosis and surrounding normal adipose, muscle and connective tissue immersed. (eurekamag.com)
  • T-16HBE-C1?5 cells all formed tumors subcutaneously in nude mice. (eurekamag.com)
  • Topotecan is a novel topoisomerase I inhibitor that may have a role in the adjuvant chemotherapy of several solid tumors, including malignant glioma. (aspetjournals.org)
  • Previous studies had confirmed that Lasp1 was significantly overexpressed in multiple malignant tumors including non-small-cell lung cancer (NSCLC) and enhanced tumor proliferation, invasion and metastasis [ 7 - 13 ]. (oncotarget.com)
  • In recent years, although significant progress has been made in the diagnosis and treatment of malignant tumors, breast cancer remains the leading cause of cancer-related deaths in women, largely due to its high rate of relapse, metastasis, and drug resistance [2-5]. (researchsquare.com)
  • Women with benign (non-cancerous) germ cell tumors such as mature teratomas (dermoid cysts) are cured by removing the part of the ovary that has the tumor (ovarian cystectomy) or by removing the entire ovary. (cancer.org)
  • As with epithelial ovarian cancers, it is a good idea to consult with a gynecologic oncologist for treating malignant germ cell tumors, especially because these are so uncommon. (cancer.org)
  • About 2-3% of all ovarian cancers are germ cell tumors. (cancer.org)
  • In general, all women with malignant germ cell tumors will have the same staging surgery that is done for epithelial ovarian cancer. (cancer.org)
  • Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD. (lu.se)
  • Here, making use of a newly generated Pdgfd knockout mouse, we reveal a functionally important malignant cell heterogeneity modulated by PDGF-DD signaling in pancreatic neuroendocrine tumors (PanNET). (lu.se)
  • Ovarian clear cell adenofibromatous tumors. (nih.gov)
  • Mast cell tumors are the most common types of skin cancer tumors. (akc.org)
  • Mast cell tumors are cancer of these cells, and they can grow anywhere on your dog's skin, as well as in internal organs. (akc.org)
  • The most common sites for mast cell tumors are the limbs, lower abdomen, and chest. (akc.org)
  • About ¬º of mast cell tumors are found on dogs' limbs. (akc.org)
  • Boxers , Pugs , Rhodesian Ridgebacks , Boston Terriers and older mixed breed dogs seem particularly susceptible to mast cell tumors, which most commonly affect dogs ages 8-to-10 years old. (akc.org)
  • Medulloblastoma (MB), one of the most malignant brain tumors of childhood, comprises distinct molecular subgroups, with p53 mutant sonic hedgehog-activated (SHH-activated) MB patients having a very severe outcome that is associated with unfavorable histological large cell/anaplastic (LC/A) features. (jci.org)
  • Some tumors are cancerous, or malignant. (cdc.gov)
  • Cells from malignant tumors can invade nearby tissues. (cdc.gov)
  • The association of Klinefelter syndrome and mediastinal nonseminomatous germ cell tumors is now well recognized. (health.am)
  • Four of 22 consecutive patients (18%) treated at Indiana University for primary mediastinal germ cell tumors had karyotypic confirmation of Klinefelter syndrome, and an additional patient had clinical features. (health.am)
  • The average age of patients with Klinefelter syndrome who develop extragonadal germ cell tumors is approximately 18 years, 10 years younger than the median age of those developing this tumor in the absence of Klinefelter syndrome. (health.am)
  • Increasing evidence indicates that many individuals who develop germ cell tumors have underlying germ cell defects. (health.am)
  • Many patients with extragonadal germ cell tumors have histories of infertility, and testicular biopsy in these patients shows various abnormalities, including decreased spermatogenesis, peritubular fibrosis, and interstitial edema. (health.am)
  • In addition, patients who are successfully treated for extragonadal germ cell tumors have a markedly increased risk of developing a subsequent testicular germ cell tumor. (health.am)
  • These data suggest that either a congenital or an acquired germ cell defect contributes not only to defective spermatogenesis but also to the development of extragonadal germ cell tumors. (health.am)
  • Hematologic Neoplasia A unique association between mediastinal nonseminomatous germ cell tumors and a variety of hematologic neoplasms is now well described. (health.am)
  • In a series of 635 patients with extragonadal germ cell tumors, 17 patients developed hematologic malignancies at a median of 6 months after the extragonadal germ cell tumor was diagnosed. (health.am)
  • All hematologic neoplasms developed in the 287 patients with mediastinal nonseminomatous germ cell tumors, for a 2% incidence in this group. (health.am)
  • Foci of malignant lymphoblasts have been recognized histologically in several mediastinal germ cell tumors. (health.am)
  • However, the specific association of leukemias and other hematologic neoplasms with mediastinal nonseminomatous germ cell tumors, rather than with all germ cell tumors, remains unexplained. (health.am)
  • In addition to hematologic neoplasia, several cases of idiopathic thrombocytopenia in association with mediastinal nonseminomatous germ cell tumors have been reported. (health.am)
  • Benign and malignant tumors of muscle and other mesenchymal origin usually do not distinguish themselves from other malignancies based on appearance alone. (radiologykey.com)
  • The least differentiated of these tumors, embryonal rhabdomyosarcoma, is composed of small, round cells and in the past may be mistaken histopathologically for lymphoma, melanoma, and fibrosarcoma, among others. (radiologykey.com)
  • Tumors are abnormal cells that cluster together. (hopkinsmedicine.org)
  • Germ cell tumors arise from abnormal cells in various parts of the body, including the ovaries, testes, chest and brain. (hopkinsmedicine.org)
  • Neuroblastoma (NB) is a pediatric cancer of the developing sympathetic nervous system that exhibits significant variation in the stage of differentiation and cell composition of tumors. (figshare.com)
  • The 5hmC profiles revealed distinct signatures characteristic to different cell lineages and stages of malignant transformation of NB cells in a conventional and oxygen-depleted environment, which often occurs in tumors. (figshare.com)
  • However, two conditions-synovial chondromatosis and tenosynovial giant cell tumors-occur in the lining (synovium) of joints. (msdmanuals.com)
  • Overview of Bone Tumors Bone tumors are growths of abnormal cells in bones. (msdmanuals.com)
  • Bone tumors may be cancerous (malignant) or noncancerous (benign). (msdmanuals.com)
  • Herein we investigated the effects of parsley root extract (PCE) on DNA synthesis performance, metabolic activity and cytotoxicity in malignant and benign breast cells. (iiarjournals.org)
  • Benign clear cell adenofibroma of the ovary. (nih.gov)
  • Benign, of low malignant potential, and associated with invasive clear cell carcinoma. (nih.gov)
  • Melanomas can be either malignant or benign. (akc.org)
  • While benign melanomas are more common, malignant melanomas are a serious concern, as they grow quickly and have a high risk of metastasis (spreading to other organs). (akc.org)
  • They may be cancerous (malignant) or noncancerous (benign). (hopkinsmedicine.org)
  • Previous studies revealed that inhibition of miR-744-3p could restore PTEN expression, and then suppressed laryngeal squamous cell carcinoma progression [ 20 ], suggesting that upregulation of PTEN could contribute to cancer development. (hindawi.com)
  • Squamous cell carcinoma is by far the most common malignancy of the tongue, typically having 3 gross morphologic growth patterns: exophytic, ulcerative, and infiltrative. (medscape.com)
  • Clinical appearance of a lateral tongue squamous cell carcinoma in an 80-year-old man with a previous history of smoking and regular alcoholic beverage consumption. (medscape.com)
  • Indications are that the incidence of squamous cell carcinoma of the mobile tongue has been rising among younger women in industrialized nations. (medscape.com)
  • The report found that the incidence of primary mobile tongue squamous cell carcinoma has significantly risen in persons under age 45 years within the populations of Australia and Singapore, with the rate of increase being significantly higher in females. (medscape.com)
  • In this study, the human bronchial epithelial cells (16HBE) were treated five times with 1 ?M benzo(a)pyrene (BaP), followed by 2 passages culture, and thein vitroBaP-induced malignant transformation of 16HBE cells was established. (eurekamag.com)
  • A malignant neoplasm of the ovary with an invasive epithelial component and a fibrotic stroma. (nih.gov)
  • The epithelial component is characterized by the presence of malignant epithelial cells with clear cytoplasm. (nih.gov)
  • Smears that contained alveolar macrophages and bronchial epithelial cells were deemed sufficient. (ganeshdiagnostic.com)
  • MiR-29a-3p was enriched in hBMSC-derived Exo, and the Exo from miR-29a-3p mimics transfected hBMSCs could inhibit laryngocarcinoma cell malignant phenotypes in vitro and prevent tumor progression in vivo . (hindawi.com)
  • DNAJB7-specific T cells were capable of killing colorectal tumor lines in vitro, and the IFN-gamma+ response was markedly magnified by control of immunosuppression with cyclophosphamide in cancer patients. (cardiff.ac.uk)
  • 5 ). Data from case reports, case series, cohort studies, in Cutavirus in Malignant vitro work, and animal studies indicate that the infectious Melanoma period for sexual transmission of Zika virus is consider- ably shorter than the period during which viral RNA can be detected in semen. (cdc.gov)
  • Functional experiments showed that PHKB knockdown significantly promoted cell proliferation both in vitro and in vivo , whereas PHKB overexpression resulted in opposing effects. (ijbs.com)
  • Additionally, in vitro assays revealed that the over (or high) expression of PHKB greatly hindered HCC cell invasion and increased apoptosis rates. (ijbs.com)
  • In addition, lung metastasis was observed in nude mice in T-16HBE-C1, 3 and 4 groups.In vitrocell migration assay results indicated that T-16HBE-C2?5 cells showed much lower migration capabilities than 16HBE cells. (eurekamag.com)
  • Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells. (nii.ac.jp)
  • Firstly, the transcriptome landscape of heterogeneous cell types in LUAD was analyzed and memory T cells, NK cells, and helper T cells were revealed to be the common immune cells in tumor, normal, and metastasis tissue, respectively. (aging-us.com)
  • Next, the results of cell-cell communication analysis suggested that pericytes interact with broad immune cells via MDK-NCL pathways in metastasis samples, MIF-(CD74+CXCR4) and MIF-(CD74+CC44) interaction especially occurred between different cell types in tumor and normal samples. (aging-us.com)
  • In this study, we collected single-cell sequencing datasets of LUAD and applied an integrated bioinformatic method to depict the transcriptome characteristic of LUAD in normal, tumoral, and metastasis condition. (aging-us.com)
  • Therefore, it is of importance to identify the molecular mechansims that drive metastasis of melanoma cells. (lu.se)
  • Malignant melanoma (MM) is one of the high degree of malignancy and early prone to blood and lymph node metastasis. (biomedcentral.com)
  • Deletion of the proximal enhancer decreases CCL5 expression and augments the cytotoxic activity of tissue-resident T and NK cells, which coincides with reduced melanoma metastasis in mouse models. (nature.com)
  • Renal cell carcinoma with pulmonary metastasis misdiagnosed as other primary malignant tumor. (bezmialem.edu.tr)
  • Our results demonstrated that BaP could induce the malignant transformation of 16HBE cells, and p53 and p-Akt (Ser473) might play crucial roles in BaP-induced carcinogenesis. (eurekamag.com)
  • In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. (nii.ac.jp)
  • Oral blue nevi are not reported to undergo malignant transformation. (medscape.com)
  • Call for an appointment with your provider if you have symptoms of malignant mesothelioma. (medlineplus.gov)
  • The aim of this study was to find out the characteristic morphology of malignant atypical cells which were missed on routine cytology of urine. (cytojournal.com)
  • In this retrospective study, we examined detailed cytomorphology of 18 cases of atypical urinary cytology which were missed on routine examination and were further proved on histopathology as transitional cell carcinoma (TCC) of bladder. (cytojournal.com)
  • Necrosis in the background and necrosed papillae were mostly seen in malignant atypical cells. (cytojournal.com)
  • The comet cells and cells with India ink nuclei (single cells with deep black structure-less nuclei) were only observed in malignant atypical cells. (cytojournal.com)
  • The present study emphasizes that nuclear features such as high N/C ratio, hyperchromasia and chromatin abnormalities are particularly useful for assessing the malignant atypical cells. (cytojournal.com)
  • Atypical cells" in urine have been recognized and studied time and again 2 3]. (cytojournal.com)
  • The accurate interpretation of the character of "Atypical cell" in urine is a major challenge for cytopathologists. (cytojournal.com)
  • In this present paper we analyzed the characteristic morphology of malignant atypical cells which were missed on routine cytology of urine. (cytojournal.com)
  • A total of 58 urine samples reported as positive for atypical cells were initially selected. (cytojournal.com)
  • However, with the addition of the clot preparation, the number of cases in which atypical/malignant cells were seen increased from 42 to 85 (19.4%), with a P (bvsalud.org)
  • The excellent adequate tory smears were divided into four categories: inflammatory, suspicious/atypical favouring neoplasia, and positive for malignant cells. (ganeshdiagnostic.com)
  • Since both human and mouse IGHV-unmutated malignant chronic lymphocytic leukemia (CLL) cells downregulated the expression of STING, we explored whether STING downregulation could contribute to the well-established robust BCR signaling phenotype in malignant CLL cells. (houstonmethodist.org)
  • The NK-92 cell series produced from a non- Hodgkin's lymphoma affected individual includes a phenotype resembling an turned WHI-P180 on NK cell [4]. (crispr-reagents.com)
  • Much more advanced in clinical development than T-cell receptor transgenic cells are cellular therapies using so-called CAR-T (chimeric antigen receptor) cells, which have already been approved for the treatment of various leukemias and lymphomas. (dkfz.de)
  • Background A synergistic effect resulting from a combination of BCL2 and MYC or MYC and CCND1 has been implicated in human B-cell lymphomas. (haematologica.org)
  • Genetic alterations of BCL2 (B-cell CLL/lymphoma 2), MYC [v-myc myelocytomatosis viral oncogene homolog (avian)] and CCND1 (cyclin D1) are the most frequently found alterations in human B-cell lymphomas. (haematologica.org)
  • 7 Importantly, it is believed that other hitherto unknown genes also play important roles in lymphomagenesis in addition to the synergistic effects of the aforementioned two oncogenes since human B-cell lymphomas often show a variety of genes subject to alterations and/or deregulated expression. (haematologica.org)
  • Her research interest is in Zika virus infection and cell lymphomas (CTCL) ( 1 , 2 ). (cdc.gov)
  • Significant differences in survival were revealed when comparison was made with developing countries, for people with cancers that can be successfully treated by chemotherapy (malignant lymphomas, leukaemia, testicular tumours) and modest differences for neoplasms that can be cured by early detection and surgical intervention. (who.int)
  • High expression of wingless-type MMTV integration site family 5A (WNT5A) has been reported in melanoma and correlates with increased migration and invasion of melanoma cells. (lu.se)
  • In this thesis, we investigate that WNT5A and interleukin-6 (IL-6) form a positive feedback loop, which accelerates the invasive property of melanoma cells. (lu.se)
  • Our results also show that acquired BRAF-inhibitor (BRAFi) resistance leads to increased expression of HuR and WNT5A in malignant melanoma cells, and simultaneous therapeutic inhibition of HuR function and WNT5A signaling could be an efficient treatment strategy to impair the invasive migration of BRAFi-resistant melanomas. (lu.se)
  • This drug that attaches to the antibody called emtansine, enters the interior of the cell and releases chemotherapy molecules, thereby directly attacks the HER2 positive tumor cells, increasing life expectancy and causing fewer side effects. (news-medical.net)
  • Most types and stages of germ cell cancers of the ovary are treated the same way, with surgery and chemotherapy (chemo). (cancer.org)
  • Patients are in need of new treatments that can improve survival outcomes, and these positive results support the potential of KEYTRUDA in combination with chemotherapy as a first-line treatment for patients with the most common form of malignant mesothelioma. (merck.com)
  • The trial evaluated KEYTRUDA in combination with chemotherapy for the treatment of patients with unresected advanced malignant pleural mesothelioma. (merck.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Further analyses revealed that simultaneously targeting HuR, with MS-444, and WNT5A signaling, with Box5, reduces melanoma cell migration and invasion via two different and partially overlapping signaling pathways, which are PKC and PI3K-AKT. (lu.se)
  • In order to design rational strategies to improve NK-92 mediated killing of paediatric pre-B ALL cells we compared the cytotoxic mechanisms and activation pathways utilized by NK-92 ci and IL-2-triggered main NK (ANK) cells against pre-B ALL cell lines. (crispr-reagents.com)
  • Background: Malignant pleural mesothelioma (MPM) is an incurable cancer predominantly induced by asbestos exposure. (aacrjournals.org)
  • Malignant pleural mesothelioma is a rapidly progressing cancer that develops in the lining of the lungs and has a poor prognosis," said Dr. Eliav Barr, senior vice president, head of global clinical development and chief medical officer, Merck Research Laboratories. (merck.com)
  • There have been few treatment advances for patients with malignant pleural mesothelioma, which can be challenging to treat through surgery and radiation alone," said Dr. Quincy Chu, CCTG's study chair of the IND.227 trial/KEYNOTE-483 trial. (merck.com)
  • Pleural mesothelioma, which develops in the lining of the lungs, is the most common form of malignant mesothelioma, accounting for about 75% of all cases. (merck.com)
  • instead, we found that PDGF-DD stimulated bulk tumor cell proliferation by induction of paracrine mitogenic signaling between heterogeneous malignant cell clones, some of which expressed PDGFRβ. (lu.se)
  • Recent evidence indicates that the hematologic neoplasms in this setting are not treatment related, but rather arise from clones of malignant lymphoblasts or myeloblasts contained within the mediastinal germ cell tumor. (health.am)
  • Previous studies indicated that exosomal miR-29a-3p derived from human bone mesenchymal stem cells (hBMSCs) could efficiently suppress cell migrative ability and vasculogenic mimicry in glioma [ 15 ]. (hindawi.com)
  • Here, we have characterized the time- and concentration-dependent toxicity of topotecan in four human malignant glioma cell lines, LN-18, LN-229, LN-308 and T98G. (aspetjournals.org)
  • CD95 ligand (CD95L)-induced apoptosis was synergistically enhanced by short-term/high concentration but not long-term/low concentration exposure to topotecan, suggesting that topotecan sensitizes human malignant glioma cells to CD95L-induced apoptosis via inhibition of RNA synthesis. (aspetjournals.org)
  • These data suggest that topotecan needs to be administered in high concentrations, such as an intratumoral polymer, to limit glioma cell growth in synergy with CD95L in vivo . (aspetjournals.org)
  • Such is the case of Trastuzumab and Pertuzumab Emtansine (T-DM1) monoclonal antibodies, which are directed to the HER2 gene that promotes the growth of cancer cells. (news-medical.net)
  • For example, miR-552 promotes cell proliferative rate of laryngocarcinoma cells by modulating p53 signaling [ 5 ]. (hindawi.com)
  • Journal Article] Cell-sheet Therapy With Omentopexy Promotes Arteriogenesis and Improves Coronary Circulation Physiology in Failing Heart. (nii.ac.jp)
  • Lasp1 (LIM and SH3 domain protein 1) promotes tumor proliferation and invasion in multiple cancer entities including non-small cell lung cancer (NSCLC). (oncotarget.com)
  • Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
  • Although several studies revealed the important role of immune cells and related marker genes impact on LUAD prognosis and process, a comprehensive understanding of TIME malignant and metastatic change in LUAD is still limited. (aging-us.com)
  • Lukas Bunse, a scientist at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and a physician at the University Medical Center Mannheim, relies on the comparatively new concept of "T cell receptor transgenic cells" in his current study: To this end, brain tumor patients were first inoculated with an antigenic fragment of the protein NLGN4X (Neuroligin4X). (dkfz.de)
  • In melanoma, the malignant black skin cancer, such T-cell receptor transgenic T cells have already been shown to prolong the lives of some patients. (dkfz.de)
  • Clinical studies show that new drugs that target malignant cells of HER2-positive breast cancer, such as Pertuzumab and Trastuzumab Emtansine (T-DM1), increase life expectancy in patients with advanced breast cancer. (news-medical.net)
  • High micromolar concentrations of topotecan, which are unlikely to be achieved in plasma in human patients in vivo , were cytotoxic within 48 hr, induced DNA fragmentation, did not induce major cell cycle changes, failed to consistently alter BCL-2 or BAX protein levels but inhibited RNA synthesis and induced cleavable DNA/topoisomerase I complex formation. (aspetjournals.org)
  • Patients with oral malignant melanoma often recall having an existing oral pigmentation months to years before diagnosis, and the condition may even have elicited prior comment from examining physicians and dentists (or healthcare providers, when considering the auxiliaries). (medscape.com)
  • More importantly, several patients have had an identical chromosomal abnormality (an isochromosome of the short arm of chromosome 12) in the neoplastic cells from the mediastinal germ cell tumor and the hematologic neoplasm, providing strong evidence for a common origin. (health.am)
  • La présente étude a estimé les fréquences relatives du cancer de la cavité buccale et du pharynx chez des patients yéménites atteints de cancers enregistrés en 2007 et 2008. (who.int)
  • In susceptible individuals, the medications induce the release of stored calcium ions within muscle cells. (wikipedia.org)
  • Bunse's team then isolated from the blood of the vaccinated individuals those T cells that had been activated by NLGN4X and consequently carried a T cell receptor that specifically "recognizes" this glioblastoma-associated antigen. (dkfz.de)
  • In this way, they succeeded in producing large numbers of T cells with identical specificity, all of which recognize the cancer antigen NLGN4X. (dkfz.de)
  • Chimeric antigen receptors (CAR) are fusion molecules that couple the HLA- independent binding of a selected cell surface target antigen to the delivery of a tailored T-cell activating signal. (aacrjournals.org)
  • These molecules are delivered to patient T-cells using retroviral gene-transfer, thereby stably re-directing their specificity for antigen. (aacrjournals.org)
  • Conclusion: This study highlights how prior methods that sequence whole tumor fractions (i.e. inclusive of alive/dead stromal cells) for antigen identification may have limitations. (cardiff.ac.uk)
  • Moreover, we show that the RNA-binding protein human antigen R (HuR) drives melanoma cell motility, and targeting HuR with a specific HuR inhibitor, MS-444, significantly reduces melanoma cell migration. (lu.se)
  • When immunized with T-independent antigens, STING V154M mice produced significantly fewer antigen-specific plasma cells and antibodies than immunized wild-type (WT) mice. (houstonmethodist.org)
  • When B cell-specific STING KO mice were T-independently immunized, they produced significantly more antigen-specific plasma cells and antibodies than immunized STING WT mice. (houstonmethodist.org)
  • As opposed to T cells NK cells aren't antigen specific but instead their activation is apparently determined by the total amount of inhibitory and activating indicators received with the NK cell upon conjugation with focus on cells [1]. (crispr-reagents.com)
  • The researchers have ruled out the possibility that the greater occurrence of the malignant tumours on the left side of the body was because one arm is exposed to the sun while driving or due to uneven sun-block application. (medindia.net)
  • Clear cell carcinoma of the ovary: is there a role of histology-specific treatment? (nih.gov)
  • Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary. (nih.gov)
  • It is found in large quantities in glioblastoma cells, but is virtually undetectable in healthy brain tissue. (dkfz.de)
  • After these initial studies had yielded such promising results, Lukas Bunse expects that vaccine-induced T-cell receptors targeting brain tumor antigens could be a promising approach to develop new immunotherapies against glioblastoma. (dkfz.de)
  • Glioblastoma multiforme (malignant brain tumor) cells. (mayoclinic.org)
  • Although incidence of malignant mesothelioma has gradually declined in the United States, continued use of and exposure to asbestos around the world has resulted in increasing global rates of this aggressive disease. (merck.com)
  • MiRNAs can also control the self-renewal or proliferation of stem cells [9]. (researchsquare.com)
  • The miR-29a-3p level was decreased, and PTEN level was elevated in laryngocarcinoma tissues and the cancer cell lines. (hindawi.com)
  • In the somatic tissues, the stem cells expressed telomerase-associated RNA, but no proliferation activity. (nih.gov)
  • The study of tissues and cells under a microscope. (cdc.gov)
  • According to the scientist, it is also conceivable to generate T cell receptor transgenic cell therapies against patient-individual cancer antigens. (dkfz.de)
  • As a common malignant tumor in the upper respiratory tract, laryngocarcinoma accounts for approximately 25 to 30% of cancer cases worldwide [ 1 , 2 ]. (hindawi.com)
  • In the malignant tumor, deregulation of telomerase is thought to facilitate tumorigenesis and cellular immortality by providing cancer cells unlimited proliferation capacity. (nih.gov)
  • Is the Subject Area "Non-small cell lung cancer" applicable to this article? (plos.org)
  • As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. (nii.ac.jp)
  • In this treatment, we identified that CD44 is up-regulated under the hypoxia and this molecule supports stemness of cancer stem cells and induces drug resistance of cancer cells. (nii.ac.jp)
  • Journal Article] DNA damage enhanced by the attenuation of SLD5 delays cell cycle restoration in normal cells but not in cancer cells. (nii.ac.jp)
  • Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer and accounts for approximately 40% of all lung cancer cases. (aging-us.com)
  • Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
  • The miRNA profile between breast cancer stem cells(BCSCs, CD44+CD24-/low) and control MCF-7 breast cancer cells was obtained in a previous study. (researchsquare.com)
  • Then, agomir-20b-5p and antagomir-20b-5p were transfected into MCF-7 and T47D breast cancer cells to detect cell migration, wound healing and proliferation, and lentivirus vectors silencing or overexpressing miR-20b-5p were transfected into T47D-CSCs to detect proliferation and apoptosis. (researchsquare.com)
  • Oncogenic miR-20b-5p was confirmed to promote the malignant behaviors of breast cancer cells and BCSCs. (researchsquare.com)
  • Previous studies have confirmed that miRNAs play an important role in gene regulation in CD44 + CD24 -/low breast cancer stem cells (BCSCs). (researchsquare.com)
  • In our previous research, we performed miRNA profiling between sorted CD44 + CD24 -/low BCSCs and the control MCF-7 breast cancer cells [8]. (researchsquare.com)
  • Malignant mesothelioma is a difficult cancer to treat. (medlineplus.gov)
  • Malignant melanoma is the most aggressive type of skin cancer, which initiates in the pigment-producing cells called melanocytes. (lu.se)
  • There is not cured for MM. Tan II A has been reported to reduce cancer cell proliferation. (biomedcentral.com)
  • In esophageal cancer, radiation therapy was found inducing autophagy in cancer cells, promoting cancer cell proliferation and causing treatment resistance [ 10 ]. (biomedcentral.com)
  • Other reports suggested that autophage suppressed cancer development in early stage and promoted cancer cell proliferation in later stage [ 4 ]. (biomedcentral.com)
  • Most women with germ cell cancer will need to be treated with combination chemo for at least 3 cycles. (cancer.org)
  • Yang W, Zhang C, Li Y, Jin A, Sun Y, Yang X, Wang B, Guo W. Phosphorylase Kinase β Represents a Novel Prognostic Biomarker and Inhibits Malignant Phenotypes of Liver Cancer Cell. (ijbs.com)
  • Because of the estimated large volume, many cancer registries do not register basal cell skin cancer except for selected sites, such as skin of the external genital organs (for example, vulva, penis, scrotum). (cdc.gov)
  • An early cancer that is present only in the layer of cells in which it began. (cdc.gov)
  • Malignant tumour seems to occur more likely on the left side according to an analysis of cancer data from Australia and other developing countries. (medindia.net)
  • A new study has found that an intense form of ultrasound that shakes a tumor until its cells start to leak can launch an attack on cancer. (medindia.net)
  • B7-H4 is Inversely Correlated With T-Cell Infiltration in Clear Cell but Not Serous or Endometrioid Ovarian Cancer. (nih.gov)
  • Malignant mesothelioma is a type of cancer that starts in the linings of certain parts of the body, including the chest, abdomen, heart and testicles. (merck.com)
  • Cancer begins in your cells when the genetic material, or DNA, is damaged or changed. (cdc.gov)
  • In addition to its roles in the regulation of inflammatory diseases and the maintenance of local immune cells, CCL5 expressed by cancer cells plays diverse roles in shaping cancer microenvironments toward their own survival. (nature.com)
  • Other studies reported that some cancer cells could repress their own CCL5 expression to hinder migration of anticancer immune cells toward cancer sites 15 , 16 . (nature.com)
  • Therefore, host CCL5 can obviously work as an anticancer molecule to mount relevant immune responses against some cancer cells. (nature.com)
  • Therefore, it might be safe to say that host CCL5 plays important roles in controlling cancer development but might create either pro- or anticancer environments according to the given situation, such as the type of cells that produce CCL5 and the type of cancers. (nature.com)
  • RÉSUMÉ Des études en milieu hospitalier ont révélé des fréquences relatives très élevées du cancer oropharyngé au Yémen. (who.int)
  • Later, a different test found that the lump was a kind of cancer called a malignant peripheral nerve sheath tumor (MPNST), specifically a malignant triton tumor. (cdc.gov)
  • Telomerase, an enzyme associated with cellular immortality, is expressed by malignant tumor and stem cells, especially germ cells. (nih.gov)
  • Germ cell cancers can raise blood levels of the tumor markers human chorionic gonadotropin (HCG), alpha-fetoprotein (AFP), and/or lactate dehydrogenase (LDH). (cancer.org)
  • therefore, the association with mediastinal germ cell tumor seems specific. (health.am)
  • MiR-125b participates in the oncogenic role of lncRNA MALAT1 in the phenotypes including cell proliferative and invasive rates in laryngocarcinoma [ 6 ]. (hindawi.com)
  • Malignant melanomas are most commonly found on the lips, mouth, and nail beds. (akc.org)
  • Malignant melanomas look like raised lumps, often ulcerated, and can also look like gray or pink lumps in the mouth. (akc.org)
  • Nail bed malignant melanomas, on the other hand, show up as toe swelling and possibly even loss of the toenail itself and destruction of underlying bone. (akc.org)
  • Based on the high cytotoxic activity and specificity for malignant cells possessed by NK-92 medical trails have opened to evaluate the feasibility of using this collection for adoptive transfer therapy [8]. (crispr-reagents.com)
  • Body cavity fluids (n = 600) received in our laboratory were processed according to a pre-designed protocol for the study as follows Day1 on receipt of the specimen, smears were made and a cell block was prepared from the sediment. (bvsalud.org)
  • Following our previous description of the serotonin transporter (SERT) acting as a conduit to 5-hydroxytryptamine (5-HT)-mediated apoptosis, specifically in Burkitt's lymphoma, we now detail its expression among a broad spectrum of B cell malignancy, while exploring additional SERT substrates for potential therapeutic activity. (erowid.org)
  • of NK-92 ci against pre-B acute lymphoblastic leukaemia cells. (crispr-reagents.com)
  • Significantly treatment of the badly killed leukaemia cells with TNF-α augmented both -independent and phosphoinositide-dependent cytolysis. (crispr-reagents.com)
  • While NK-92 is an efficient killer of a wide variety of leukaemia cell types its level of cytotoxicity is definitely least expensive against B-lineage acute lymphoblastic leukaemia (ALL) [5]. (crispr-reagents.com)
  • SERT was readily detected in derived B cell lines with origins as diverse as B cell precursor acute lymphoblastic leukemia, mantle cell lymphoma, diffuse large B cell lymphoma, and multiple myeloma. (erowid.org)
  • About 4% of cases of diffuse large B-cell cell lymphoma possess BCL2/MYC double translocations, suggesting a synergistic effect of BCL2 and MYC in lymphoma development. (haematologica.org)
  • 8 - 12 Cases of CCND1/MYC double translocation are relatively frequent in mantle cell lymphoma. (haematologica.org)
  • Importantly, human B-cell lymphoma cases with concurrent multiple translocations including BCL2 , MYC and CCND1 have been reported. (haematologica.org)
  • MiR mimics could inhibit proliferative, invasive migratory rates while promoting apoptotic rates of M4E and Hep2 cells. (hindawi.com)
  • Recently, few studies revealed that miR-29a-3p could suppress the proliferative and invasive rates in laryngocarcinoma cells [ 10 , 11 ]. (hindawi.com)
  • Tan II A reduced CXCL12-induced A375 cell invasive ability and migration in a dose dependent manner. (biomedcentral.com)
  • Napsin A is a specific marker for ovarian clear cell adenocarcinoma. (nih.gov)
  • Autophagy plays an important role in cell growth, development and disease suppression. (biomedcentral.com)
  • Worldwide, it is estimated there were more than 30,000 new cases of malignant mesothelioma diagnosed and more than 26,000 deaths from the disease in 2020. (merck.com)
  • The usage of NK cells in adoptive therapy for malignant disease can be an specific section of great potential. (crispr-reagents.com)
  • extended cytotoxic cells can be an specific section of extensive investigation for the treating malignant disease. (crispr-reagents.com)
  • the level of NK-92 ci killing of pre-B ALL cells is determined by three distinct mechanisms and demonstrate strategies to enhance the potential use of the collection as a restorative agent for this disease. (crispr-reagents.com)
  • Due to the critical significance of early and accurate detection in improving the survival rate of a patient with a malignant granular cell tumor, an oncologist will order a number of diagnostic tests to produce rapid correct findings. (newhopemedicalcenter.com)
  • Smeere thought inadequate were those that had deteriorated or poorly preserved cell morphology, as well as extensive haemorrhage that obscured cellular features. (ganeshdiagnostic.com)
  • Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas. (stembook.org)
  • While macrophages were reported to act as one of the cells in LUAD, enrichment analysis of macrophage marker genes revealed the important role of macrophages in the activation of neutrophils. (aging-us.com)
  • Tenosynovial giant cell tumor (also known as pigmented villonodular synovitis [PVNS]) causes the lining of the joint to become swollen and grow. (msdmanuals.com)
  • Tenosynovial giant cell tumor usually affects one joint. (msdmanuals.com)
  • Significantly preclinical data claim that the NK-92 cell series will have a minimal tumorigenic risk in immunocomprimized people [5 6 This risk could be additional reduced by irradiation that will not decrease cytotoxic activity [7]. (crispr-reagents.com)
  • Malignant granular cell tumor (MGCT) is a high-grade mesenchymal tumor of Schwann cell origin. (newhopemedicalcenter.com)
  • The exosomes (Exo) from human bone marrow mesenchymal stem cells (hBMSCs) after the transfection of miR mimics/inhibitor/si-PTEN were isolated and used to stimulate M4E and Hep2 cells. (hindawi.com)
  • Taken together, our results extend our knowledge about WNT5A regulation in melanoma and highlight the importance of HuR and WNT5A in melanoma cell migration and invasion. (lu.se)
  • To assess this phenomenon, we established tumor myofibroblasts cell line and analyzed the up-regulating genes in myofibroblasts upon exposure with hypoxia and/or serum starvation. (nii.ac.jp)
  • citation needed] There is mounting evidence that some individuals with malignant hyperthermia susceptibility may develop MH with exercise and/or on exposure to hot environments. (wikipedia.org)
  • We sought to explore the possible mechanism by which Tan II A regulated cell proliferation through autophagy signaling pathway in A375 cells. (biomedcentral.com)
  • Histologically, the tumor was composed of polygonal cells exhibiting diffuse hemorrhage, multifocal necroses, and vascular invasion. (nih.gov)
  • In this study, single-cell sequencing datasets of LUAD were utilized to depict the transcriptome characteristic of LUAD based on the bioinformatic method. (aging-us.com)
  • Urine cytology for screening of transitional cell carcinoma (TCC) has been used for long time. (cytojournal.com)
  • The cytological methods currently available for examining the pathology of the lung include exfoliative (induced sputum), abrasive (bronchoalveolar lavage [BAL], bronchial brushing [BB], bronchial washing, and percutaneous/endobronchial fine-needle aspiration cytology), and percutaneous/endobronchial cytology.BBs have a higher cell yield than aspirates and washing. (ganeshdiagnostic.com)
  • Other cytological features such as comet cells and cells with India ink nuclei are also helpful for diagnosis but have limited value because they are less frequently seen. (cytojournal.com)
  • Results: Studies to date have shown that human T-cells engineered to express cMet CARs can destroy mesothelioma tumour cell monolayers, accompanied by T-cell proliferation and cytokine production. (aacrjournals.org)