Cells evidence hypoxia ischemia. Medical search. Frequent questions

Here, we modeled TH action in the brain using an in vitro coculture system of D2-expressing H4 human glioma cells and D3-expressing SK-N-AS human neuroblastoma cells. (jci.org)
Furthermore, this paracrine pathway was regulated by signals such as hypoxia, hedgehog signaling, and LPS-induced inflammation, as evidenced both in the in vitro coculture system and in in vivo rat models of brain ischemia and mouse models of inflammation. (jci.org)
In vitro, HL-1 cells (mouse cardiomyocytes) received chamber hypoxia-oxygenation reperfusion (H/R) for 24H4R with/without DLC1β plasmid, before collection for protein/mRNA analyses. (uwo.ca)
In the present study, we examined the ability of rat glial cells to produce NO following hypoxia/reoxygenation in vitro by measuring nitrite. (elsevierpure.com)
Cardiac ischemia is modelled in vitro through the application of hypoxic and oxidative stress. (biomedcentral.com)
Both in vitro and in vivo models of cerebral ischemia/reperfusion (I/R) injury presented a sharp increase in NRP-1 expression. (biomedcentral.com)
To study the role of hypoxia-inducible factor-1 (HIF-1α) and Wnt signaling in cerebral ischemia/hypoxia-induced proliferation of neural stem cells (NSCs), we investigated the proliferation of NSCs, expression of HIF-1α, and activation of Wnt signaling under conditions of pathologic hypoxia in vitro. (johnshopkins.edu)
Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)

DJ‑1 protein, as a multifunctional intracellular protein, has been demonstrated to serve a critical role in regulating cell survival and oxidative stress. (spandidos-publications.com)
To provide in vivo evidence that DJ‑1 is involved in the delayed cardioprotection induced by ischemic preconditioning (IPC) against oxidative stress caused by ischemia/reperfusion (I/R), the present study subjected male Sprague‑Dawley rats to IPC (3 cycles of 5‑min coronary occlusion/5‑min reperfusion) 24 h prior to I/R (30‑min coronary occlusion/120‑min reperfusion). (spandidos-publications.com)
Ischemia/reperfusion (I/R) in mouse hearts and hypoxia/oxidative stress in neonatal rat cardiomyocytes have been associated with a downregulation of MG53. (biomedcentral.com)
Mitochondria, a powerhouse of the cell, are rich in a large number of enzymes, which not only participate in cellular oxidative phosphorylation and ATP synthesis, but also regulate intracellular calcium ions and reactive oxygen species to maintain cellular homeostasis. (biomedcentral.com)
During the early stage of cerebral I/R injury, significantly-swollen mitochondria decrease adenosine triphosphate (ATP) and produce excessive reactive oxygen species (ROS) and oxidative stress, finally resulting in cell death [ 6 ]. (biomedcentral.com)
Hmox1 ) enzyme system is among the most important inducible mechanisms for cell protection against oxidative damage in the cardiovascular system. (jci.org)
Such HPC may enhance cellular tolerance to subsequent hypoxia-induced oxidative stress, simulating the protective effects of IPC, taking advantage of convenient and non-invasive intervention ( 3 , 4 ). (spandidos-publications.com)
In the absence of efficient protection by antioxidant factors and other molecules such as flavonoids, oxidative stress is responsible for the release of iron in reactive form, predisposing red cells to hemolysis through the formation of senescence antigen. (unisi.it)
Other well-known sources of oxidative stress in red cells are free radical production outside the red cell by activated phagocytes, endothelial metabolism, hyperoxia, ischemia-reperfusion and the arachidonic acid cascade. (unisi.it)
CONCLUSION: The recent insight into the mechanism of oxidative injury of red cells and evidence of relationships between erythrocyte oxidative stress and hypoxia suggest that increased hemolysis is induced by severe hypoxia and acidosis in the fetus as well as the newborn. (unisi.it)
[ 2 ] All dementia share common molecular mechanisms responsible for disease etiology and progression, such as hypoxia and oxidative stress, neuroinflammation, mitochondrial bioenergetics, neurodegeneration, and blood-brain barrier permeability. (medscape.com)

Cardiac ischemia-reperfusion injury (IRI) occurs intra-operatively during heart transplantation (HTx), underpinning graft survival. (uwo.ca)
Cardiac ischemia-reperfusion injury (IRI) occurs when transplanting a heart from donor to recipient. (uwo.ca)
However, accumulating evidence suggests that MG53 has a potentially protective role in heart tissue, including in ischemia/reperfusion injury of the heart, cardiomyocyte membrane injury repair, and atrial fibrosis. (biomedcentral.com)
Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. (harvard.edu)
2. Siemionow M, Arslan E. Ischemia/reperfusion injury: a review in relation to free tissue transfers. (scielo.br)
Review: Ischaemia-reperfusion injury in flap surgery. (scielo.br)
Cold ischemia and subsequent reperfusion injury are non-immunologic cornerstones in the development of graft injury after heart transplantation. (frontierspartnerships.org)

Cardiac ischemia/reperfusion (I/R) injury is a serious disease and threatens human health [ 1 ]. (hindawi.com)
Reperfusion treatment has a potential risk of worsening tissue damage after ischemia, which can accelerate the deterioration of cardiac function [ 2 ]. (hindawi.com)
Chronic hypoxia in the presence of high glucose leads to progressive acidosis of cardiac myocytes in culture. (biologists.com)
The "ischemia" phase of cardiac IRI occurs when the donor heart is being collected and blood/oxygen is not going to the heart. (uwo.ca)
Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)
Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
Marrow-derived mesenchymal stem cells ( MSC ) express cardiac specific protein in co-culture. (anl.gov)
Mesenchymal stem cells secrete factors that inhibit apoptosis in H9c2 cardiac myoblasts. (anl.gov)
Bone marrow mesenchymal stem cells secrete factors that exert anti-apoptotic and pro-apoptotic effects on H9c2 cardiac myoblasts. (anl.gov)
These results indicate that cardiac Hmox1 induction not only prevents heme toxicity, but also regulates the timing and registration of genetic programs for mitochondrial quality control that limit cell death, pathological remodeling, and cardiac fibrosis. (jci.org)
Reperfusion after cardiac ischemia increases cell death and infarct size (IS), called myocardial ischemia/reperfusion (I/R) injury, which is the main cause of myocardial injury during the cardiac surgery particularly in coronary artery bypass graft surgery ( 1 , 2 ). (spandidos-publications.com)
Cerebral hypoxia-ischemia causes cardiac damage in a rat model. (otago.ac.nz)
Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)
If treated with cardiopulmonary resuscitation, however, cardiac arrest is survivable, but survivors often show evidence of injury in selectively vulnerable regions of the brain. (cdc.gov)

The NOS inhibitor, N(G)-monomethyl-L-arginine, decreased hypoxia-induced nitrite formation. (elsevierpure.com)

The idea of myocardial regeneration with stem cell transplantation after myocardial infarction receives tremendous interest. (escardio.org)
Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
Acute coronary syndrome (ACS) describes any condition characterized by myocardial ischaemia and reduction in blood flow. (hindawi.com)
Acute coronary syndrome (ACS) is a cardiovascular disease, which describes any condition characterized by signs and symptoms of sudden myocardial ischaemia and reduction in blood flow to the heart [ 1 ]. (hindawi.com)
Intravenous administration of mesenchymal stem cells ( MSC ) following myocardial infarction prevents contractile dysfunction. (anl.gov)
metabolic acidosis, arrhythmias, myocardial ischemia or infarction, and noncardiogenic pulmonary edema, although any organ system might be involved. (cdc.gov)
IPC involves single or multiple brief periods of sublethal ischemia, which increase myocardial resistance to a greater subsequent insult. (spandidos-publications.com)
MG53 KO mice lack IPC-mediated cardioprotection as evidenced by a failure of IPC to reduce IR-induced myocardial infarct size. (biomedcentral.com)
Adult rats were subjected to myocardial ischemia/reperfusion (I/R) injury with or without ischemic preconditioning (IPC), and the level of miR‑133b‑5p in myocardium was measured. (spandidos-publications.com)
Hypoxia/reoxygenation (H/R) as well as hypoxic preconditioning (HPC) is widely used for simulating in vivo myocardial I/R and ischemic preconditioning (IPC) in a cell culture model. (spandidos-publications.com)
In addition, inhaled hypoxic air preconditioning including intermittent hypoxia has been suggested a potential non-pharmacological therapeutic intervention to improve some cardiovascular diseases such as hypertension, myocardial infarction. (spandidos-publications.com)
The nitric oxide donor S-nitroso-human-serum-albumin (S-NO-HSA) is known to attenuate myocardial ischemia-reperfusion (I/R)-injury. (frontierspartnerships.org)

leaves alleviate hypoxia/reoxygenation (H/R) injury in H9c2 cardiomyocytes and to explore potential mechanisms. (hindawi.com)
In murine cardiomyocytes miR-21 was found to protect from hypoxia/reoxygenation (H/R)-induced cell apoptosis via regulation of its target gene PDCD4 [ 13 ]. (hindawi.com)
Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
Our previous study revealed that hypoxia preconditioning of H9c2 cardiomyocytes significantly increased the de novo synthesis of DJ-1 and induced cardioprotection against prolonged hypoxic injury 24 h later ( 17 ). (spandidos-publications.com)
Since cardiomyocytes are terminally differentiated cells with limited self-renewal capacity, and membrane rupture is a major cause of cardiomyocyte cell death following injury, membrane repair is a necessary process for preserving cardiomyocyte viability [ 6 ]. (biomedcentral.com)
Neonatal rat cardiomyocytes were isolated and subjected to hypoxia/reoxygenation (H/R) injury, with or without HPC. (spandidos-publications.com)
HPC protected neonatal rat cardiomyocytes against H/R injury by increasing cell viability, while reducing LDH release and cell apoptosis. (spandidos-publications.com)
However, the knockdown of miR‑133b‑5p in the cardiomyocytes blocked HPC‑mediated cardioprotection as reflected by the aggravation of cell injury and apoptosis. (spandidos-publications.com)
Vascular endothelial cell (EC)-derived factors play an important role in endothelial-cardiomyocyte crosstalk and could save cardiomyocytes (CMs) from injury. (mdpi.com)

This hypoxia-induced, glial cell-derived NO may play a critical role in the pathogenesis of cerebral ischemia in vivo. (elsevierpure.com)
The present study therefore provided novel evidence that DJ‑1 is involved in the delayed cardioprotection of IPC against I/R injury in vivo. (spandidos-publications.com)
However, whether the increase in DJ-1 expression mediates protection against ischemia/reperfusion (I/R) injury in vivo during the late phase of IPC remains to be determined. (spandidos-publications.com)
Murine models of Matrigel plug and hindlimb ischemia were employed as in vivo angiogenic assays. (biomedcentral.com)
Moreover, Ad5HRE:BDNF injection resulted in significantly improved sensorimotor scores 7 days after MCAO and induced a reduction in the number of Fluoro-Jade B-positive neurons Nepicastat in vivo and TUNEL-positive cells, compared with vehicle- or AdNull-injection. (a-inhibitor.com)

Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) exerts inhibitory and cytotoxic effects on various cells including neuronal cells. (elsevierpure.com)
Hypoxia inducible aspect-1 (HIF-1) is certainly a proteins normally scarce in cells, but upregulated during ischemia/hypoxia [41] greatly. (baxkyardgardener.com)

Prenatal hypoxia-ischemia to the developing brain has been strongly implicated in the subsequent development of the hypertonic motor deficits of cerebral palsy (CP) in premature and full-term infants who present with neonatal encephalopathy. (jneurosci.org)
Hypoxia-ischemia (H-I) is also associated with subsequent cerebral injury in a disproportionately high percentage of the survivors of premature birth ( Volpe, 2001 ). (jneurosci.org)
and is an intrinsic process through which repeated short episodes of ischemia are instituted to protect the myocardium against subsequent ischemic insults [ 7 ]. (biomedcentral.com)
However, little is known about how hypoxia affects the ability of microglia, resident CNS macrophages, to respond to subsequent inflammatory challenges that are often present during neurodegenerative processes. (frontiersin.org)
There is substantial evidence that endothelial injury during organ procurement and preservation, caused by ischemia and subsequent reperfusion, results in endothelial dysfunction. (frontierspartnerships.org)
In response to COVID-19 infection, activation of T cells along with massive production and release of cytokines occur with subsequent damage to internal organs, and primarily the lungs (2). (who.int)
The sickle erythrocyte presents reduced flexibility and becomes more adherent to vascular endothelium, developing vaso-occlusion of microvasculature and subsequent local hypoxia 1,7 . (bvsalud.org)
Kermanshah Province in sponse to COVID-19 infection, activation of T cells along the west of the country borders Iraq and has extensive with massive production and release of cytokines occur communication with the Iraqi Kurdistan region, which with subsequent damage to internal organs, and primari- could be a challenge in disease control. (who.int)

In glial cells after hypoxia/reoxygenation, the iNOS mRNA and protein expressions were detected by reverse-transcription polymerase chain reaction and by immunocytochemical analysis, respectively. (elsevierpure.com)

strong class="kwd-title" Keywords: close head injury, brain edema, MnSOD, hypoxia, 2ME2 Introduction Brain edema Seliciclib inhibitor database leading to an growth of brain volume has a crucial impact on morbidity and mortality following traumatic brain injury (TBI) as it increases intracranial pressure, impairs cerebral perfusion and oxygenation, and contributes to additional ischemic/hypoxic injuries [40]. (baxkyardgardener.com)
our findings suggest that BDNF expression could be regulated in hypoxia/ischemia condition with five copies of HRE and ameliorates ischemic brain injury in a mouse focal cerebral ischemia model. (a-inhibitor.com)

Most previous studies have employed models of cerebral hypoxia-ischemia in postnatal animals. (jneurosci.org)

To test this, we pre-exposed immortalized N9 and primary microglia to hypoxia (1% O 2 ) for 16 h and then challenged them with pro-inflammatory lipopolysaccharide (LPS) either immediately or 3-6 days following hypoxic exposure. (frontiersin.org)
Although hypoxic or ischemia tolerance in AGS involves physiological adaptations, little is known about the critical cellular mechanisms underlying intrinsic AGS cell resilience to metabolic stress. (elifesciences.org)

The cannabinoid CB 2 receptor agonist GW405833 does not ameliorate brain damage induced by hypoxia-ischemia in rats. (otago.ac.nz)
We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)

IPC suppressed IR-induced infarction in wild type (WT) mouse hearts whereas overexpression of GFP-MG53 fusion protein reduced hypoxia- or H 2 O 2 -induced cell death [ 8 ]. (biomedcentral.com)

Undifferentiated endothelial cells are critical to the development of retinal vessels. (medscape.com)
[ 7 ] Retinal endothelial cells give rise to primitive capillaries that further differentiate into mature vessels. (medscape.com)
First, an incident/stressor caused hypoxia in the infant, which led to retinal hypoperfusion. (medscape.com)
To provide a focused review of sickle cell retinopathy in the light of recent advances in the pathogenesis, multimodal retinal imaging, management of the condition, and migration trends, which may lead to increased prevalence of the condition in the Western world. (onescdvoice.com)
Sickle retinopathy results from aggregation of abnormal hemoglobin in the red blood cells in the retinal microcirculation, leading to reduced deformability of the red blood cells, stagnant blood flow in the retinal precapillary arterioles, thrombosis, and ischemia. (onescdvoice.com)

The condition in which tissue oxygen levels are reduced to below around 30 mmHg is known as ischemia or tissue hypoxia, and this state fundamentally impairs the normal cellular processes and inhibits wound healing. (woundeducators.com)
PTMScan ® Technology enables researchers to isolate, identify, and quantitate large numbers of post-translationally modified cellular peptides with a high degree of specificity and sensitivity, providing a global overview of PTMs in cell and tissue samples without preconceived biases about where these modified sites occur (1). (cellsignal.jp)
Intra- and postoperative monitoring of flap microcirculation may provide useful information for better understanding and following-up the ischemia-reperfusion-related alterations in tissue perfusion 6 6. (scielo.br)

Hypoxia decreases astrocyte-mediated thyroid hormone signaling in neuronal SK-N-AS cells. (jci.org)
In summary, our data suggest that the activation of AMPK and its regulation of cell surface GLUT3 expression is critical in mediating neuronal tolerance to excitotoxicity. (jneurosci.org)
We have characterized an AMP-mediated activation of AMPK that facilitates the translocation of GLUT3 to the neuronal cell surface after excitation. (jneurosci.org)
In physiological conditions, H 2 S has been found to induce the formation of long-term potential in neuronal cells by augmenting the activity of N-methyl-D-aspartate (NMDA) receptor. (springer.com)
Likewise, it also actively takes part in the regulation of intracellular Ca 2+ and pH homeostasis in both neuronal cells and glia cells. (springer.com)
Amyloid plaques with evidence of damaged neuronal processes are called neuritic plaques. (medscape.com)

H9c2 cells pretreated with TFs for 24h were exposed to H/R treatment. (hindawi.com)
The protective effects of TFs resulted in higher expression of miR-21 in H/R-induced H9c2 cells than that of controls, which in turn upregulated Akt signaling activity via suppressing the expression of PTEN together with decreasing the ratio of Bax/Bcl-2, caspase3, and cleaved-caspase3 expression in H/R-induced H9c2 cells. (hindawi.com)
Moreover, we have found that TFs can increase the activity of superoxide dismutase (SOD) and reduce the level of malonaldehyde (MDA) together with lactate dehydrogenase (LDH) in H9c2 cells. (hindawi.com)
To test this hypothesis, we attempted to investigate whether TFs can exert its cardioprotective effect and the effects of TFs on miR-21 in H9c2 cells. (hindawi.com)
Results were confirmed via H9C2 (rat cardiomyocyte) cell lines. (uwo.ca)

This may be precipitated by hypoxia, acidosis, and hyperosmolarity. (onescdvoice.com)

Our study suggests that TFs can decrease cell apoptosis, which may be mediated by altering the expression of miR-21, PTEN/Akt, and Bcl/Bax. (hindawi.com)
There is a signal crosstalk between autophagy and apoptosis, which may be regulated to produce synergistic effect on the preconditioning of stem cells. (biomedcentral.com)

MIF was identified as a major regulator of atherogenesis by promoting the recruitment of mononuclear cells, activating inflammatory signaling pathways, and transdifferentiating macrophages into foam cells in the vessel wall as well as by enhancing collagenase expression and matrix degradation, the latter contributing to plaque destabilization [ 18 - 20 ]. (hindawi.com)
While emphasis was previously placed on hypoxia / ischemia, epidemiological, clinical, experimental and other studies conducted over the last decade have provided evidence for an important role of infective / inflammatory conditions and immune mediators in the pathogenesis of periventricular leukomalacia. (eurekaselect.com)
Tumor necrosis factor alpha (TNF-a), interleukin-1 beta (IL-1b) and interleukin-2 (IL-2) are overexpressed in affected brains, and receptors for these cytokines are present on many inflammatory and neural cells in the white matter. (eurekaselect.com)
There is also evidence for interaction between infective / inflammatory conditions and ischemia / hypoxia as etiopathogenic factors in periventricular leukomalacia / cerebral palsy, as the former may enhance the effects of the latter. (eurekaselect.com)
We, therefore, tested the hypothesis that hypoxia would enhance or "prime" microglial pro-inflammatory gene expression in response to a later inflammatory challenge without programmatically increasing basal levels of pro-inflammatory cytokine expression. (frontiersin.org)
These findings provide evidence that hypoxia pre-exposure could lead to persistent and aberrant inflammatory responses in the context of CNS disorders. (frontiersin.org)
Traditionally, M2 polarization is driven by anti-inflammatory cytokines secreted by T helper 2 cells in the late stages of infection [ 13 ]. (biomedcentral.com)
Similarly, chronically CCl(4)-treated SRC-3(-/-) mice showed significant weakening of inflammatory infiltrates, hepatic stellate cell activation and collagen accumulation in the liver compared with SRC-3(+/+) mice. (a-inhibitor.com)

Dysfunctional endothelium is a key factor in atherosclerosis that favors the increase of the expression of chemotactic and adhesion molecules (such as, intercellular adhesion molecule 1, ICAM1, and vascular cell adhesion molecule 1, VCAM1, as well as E-selectin and P-selectin) and enhanced recruitment and accumulation of monocytes [ 6 , 8 , 9 ]. (hindawi.com)
Recently a key participant in neovascularization, the endothelial progenitor cell, has been the subject of intense cardiovascular research to explore whether it can serve as a biomarker for vascular injury. (biomedcentral.com)
AQP4 is usually expressed in astrocyte foot processes near capillaries and in ependymal cells lining the ventricles-key sites for water movement between the cellular, vascular, and ventricular compartments. (baxkyardgardener.com)
9. Chan CK, Vanhoutte PM. Hypoxia, vascular smooth muscles and endothelium Acta Pharmaceutica Sinica B. 2013;3(1):1-7. (scielo.br)

Notably, inhibition of the CaMKK (calmodulin-dependent protein kinase kinase) had little affect on GLUT translocation, whereas the inhibition or knockdown of AMPK (compound C, siRNA) activity prevented GLUT3 translocation to the cell surface after glutamate excitation. (jneurosci.org)
2009), but the ketogenic diet has been further shown to be neuroprotective in animal models of several central nervous system (CNS) disorders, including Alzheimer's disease (AD), Parkinson's disease, hypoxia, glutamate toxicity, ischemia, and traumatic brain injury (TBI) (see Prins, 2008, for a review). (nationalacademies.org)

These findings indicate that pathologic hypoxia stimulates NSC proliferation by increasing expression of HIF-1α and activating the Wnt/β-catenin signaling pathway. (johnshopkins.edu)
Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux. (nature.com)
The Cdk5-AMT signal pathway involved in regulation of DDR by TIGAR defines a new role of TIGAR in cancer cell survival and it suggests that TIGAR may be a therapeutic target for cancers. (nature.com)

However, whether NRP-1 can repair mitochondrial structure and promote functional recovery after cerebral ischemia is still unknown. (biomedcentral.com)
Therefore, promoting the mitochondrial structural repair and functional recovery is the crucial for the amelioration of the neurological damage after cerebral ischemia. (biomedcentral.com)

TACE induced a reduction in tumor size mainly due to ischemia resulting from embolization 11 which expose tumor to acute hypoxia. (nature.com)
Here, we provided genetic evidence that mice lacking steroid receptor co-activator-3 (SRC-3) were protected against carbon tetrachloride (CCl(4))induced acute liver necrosis and chronic hepatic fibrosis. (a-inhibitor.com)
Aniline may also cause the destruction of red blood cells, which manifests as acute or delayed hemolytic anemia. (cdc.gov)

More recently, the factors involved in denaturating of membrane proteins and lipid peroxidation have been investigated in detail, as well as the mechanism of reactive oxygen species formation in red cells. (unisi.it)
However, as examples, oxygen is essential in all cellular metabolic processes, including fibroblast proliferation, collagen synthesis, exportation of collagen from the fibroblast cell membrane and neoepithelialization. (woundeducators.com)
The principal mechanisms of this modality are based the on intracellular generation of reactive species of oxygen and nitrogen, which are known to play a central role in cell signal transduction cascades (see Figure 1). (woundeducators.com)
Excessive oxygen administration was felt to contribute to this hypoxia. (medscape.com)
Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
One such animal is the Arctic ground squirrel, an extreme hibernator that can drop its body temperatures to below 0°C. This hibernation ability means the cells of Arctic ground squirrels can survive severe shortages of blood and oxygen. (elifesciences.org)
found that when this variant form of ATP5G1 was introduced into the cells of mice, their mitochondria was better at coping with stress conditions, such as low oxygen, low temperature and poisoning. (elifesciences.org)
Insufficient delivery of oxygen and destruction of red blood cells may cause cardiopulmonary complaints with the development of ischemia, arrhythmia and shock. (cdc.gov)

Through cell survival-based cDNA expression screens in neural progenitor cells, we identify a genetic variant of AGS Atp5g1 that confers cell resilience to metabolic stress. (elifesciences.org)
But, it is unclear how their cells are able to endure this metabolic stress. (elifesciences.org)
This protein is found in a cellular compartment called the mitochondria, which is responsible for supplying energy to the rest of the cell and therefore plays an important role in metabolic processes. (elifesciences.org)
These findings provide the first evidence of a protein variant that is responsible for protecting cells during the metabolic stress conditions caused by hibernation. (elifesciences.org)

The manipulation of endothelial cells to secrete protective factors could enhance cardioprotection. (mdpi.com)

We found that glial cell D2 activity resulted in increased T3 production, which acted in a paracrine fashion to induce T3-responsive genes, including ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), in the cocultured neurons. (jci.org)
This study therefore presents what we believe to be the first direct evidence for a paracrine loop linking glial D2 activity to TH receptors in neurons, thereby identifying deiodinases as potential control points for the regulation of TH signaling in the brain during health and disease. (jci.org)

Intriguingly, emerging evidence indicates a connection of H 2 S with Parkinson's disease. (springer.com)

In the present review, focusing on responses to ELF-EMFs and pulsed EMFs (PEMFs), we discuss experimental evidence and unmet issues of this hypothesis, in the context of the current view of the immune system. (frontiersin.org)
In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
There is increasing evidence from clinical and experimental studies for a causative role of chronic inflammation in initiation and progression of atherosclerosis [ 10 ], where the release of cytokines from platelets, immune, endothelial and smooth muscle cells play a key role [ 10 , 11 ]. (hindawi.com)
Herein, the relevant mechanisms are recapitulated based on the existing literature and experimental evidence. (biomedcentral.com)

Results showed that TIGAR was increased and relocated to the nucleus after epirubicin or hypoxia treatment in cancer cells. (nature.com)

These findings provide a unique behavioral model to define mechanisms and sequelae of perinatal brain injury from antenatal hypoxia-ischemia. (jneurosci.org)
Evidence indicates that after brain injury, neurogenesis is enhanced in regions such as hippocampus, striatum, and cortex. (johnshopkins.edu)
Addititionally there is evidence the fact that appearance of AQP9 are available in astrocytic end foot and could play an essential function in aggravation of distressing human brain edema [4,33]. (baxkyardgardener.com)
Consequently, fatty acid oxidation becomes favored, and the liver converts fat into fatty acids and ketone bodies that serve as an efficient alternative fuel for brain cells. (nationalacademies.org)
Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)

We found that microglia exhibited enhanced responses to LPS 3 days and 6 days post-hypoxia. (frontiersin.org)

Preterm Fetal Hypoxia-Ischemia Causes Hypertonia and Motor Deficits in the Neonatal Rabbit: A Model for Human Cerebral Palsy? (jneurosci.org)

There is mounting evidence to suggest that XBP1s performs a critical function in a range of different cardiovascular diseases (CVDs), indicating that it is necessary to gain a comprehensive knowledge of the processes involved in XBP1s in various disorders to make progress in research and clinical therapy. (mdpi.com)
1.3 One literature review based on a combination of clinical trials, nonrandomized trials, cohort studies, retrospective analyses, and case series showed evidence that HBOT promotes healing of arterial ulcers, calciphylactic ulcers, refractory vasculitic ulcers, and osteomyelitis, as well as the success of treatment for compromised ﬂaps and grafts. (woundeducators.com)
Despite evidence of efficacy and a track record of clinical use and animal research on the ketogenic diet's antiepileptic action, the mechanisms by which the ketogenic diet confers neuroprotection are still poorly understood. (nationalacademies.org)
In sickle cell trace, the heterozygosis for genes of normal (HbA) and mutant (HbS) hemoglobins (AS genotype) does not exhibit clinical symptoms of the disease under physiological conditions 3,5 . (bvsalud.org)

C ) ENPP2 mRNA levels in SK-N-AS cells at the indicated time points. (jci.org)

Composite flaps used in reconstructive surgery may intra- and postoperatively suffer from hypoperfusion and/or ischemia-reperfusion influencing wound healing. (scielo.br)

Epirubicin, a DNA damaging anticancer agent and CoCl 2 , which was used to imitate hypoxia condition, was applied to induce DNA damage in TIGAR knockdown HepG2 cells. (nature.com)

Pathologic findings in liver biopsy are (1) high-grade venous congestion and centrilobular liver cell atrophy, and, possibly, (2) thrombi within the terminal hepatic venules. (medscape.com)
Hepatic function can be affected to a degree, depending on the amount of stasis and resultant hypoxia. (medscape.com)

These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
The resistant state of skeletal myoblasts to ischemia renders these cells suitable candidates for repair of chronically infracted and failing heart (5). (escardio.org)

Cell Mol Life Sci, 2022 Sep 15. (nih.gov)

Effect of short-term ischemia on microcirculation and wound healing of adipocutaneous flaps in the rat 1 1 Research performed at Department of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary. (scielo.br)
We aimed to follow-up the effect of ischemia on adipocutaneous flaps' wound healing and microcirculation. (scielo.br)
Short-term ischemia could influence flap microcirculation and wound healing, and may result in hypertrophized mammary glands. (scielo.br)
Klarik Z, Tamas R, Toth E, Kiss F, Kovacs EL, Jäckel M, Furka I, Nemeth N. Intra and postoperative evaluations of microcirculation and micro-rheological parameters in a rat model of musculocutaneous flap ischemia-reperfusion. (scielo.br)

The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
In this review, we examine the identity of the endothelial progenitor cell as well as the evidence that support its role as a key responder after burn insult. (biomedcentral.com)
While there is conflicting evidence with regards to the delta of endothelial progenitor cell mobilization and burn severity, it is clear that they play an important role in wound healing. (biomedcentral.com)
One particular element that is beginning to garner interest involves the systemic mobilization of endothelial progenitor cells (EPCs). (biomedcentral.com)

The transplantation of bone marrow-derived mesenchymal stem cells (BMMSCs) alleviates neuropathology and improves cognitive deficits in animal models with Alzheimer's disease. (biomedcentral.com)

Uterine ischemia in the dams resulted in a distinct neurobehavioral phenotype in the newborn pups, which was characterized by an increase in forelimb tone that was significantly correlated with histological evidence of persistent injury to subcortical motor pathways involving the basal ganglia and anterior thalamus. (jneurosci.org)
It is more accurate to use "Sudden Unexpected Infant Death" if there is no external evidence of injury to the infant and no scene information to suggest another cause of death. (medscape.com)
Treatment with DLC1β-OE reduced IRI as evidenced by decreased cumulative injury via histopathology. (uwo.ca)
Cellular injury was evaluated by detecting cell viability, lactate dehydrogenase (LDH) activity and apoptotic rate. (spandidos-publications.com)
The evidence with regards to EPC mobilization following trauma, and particularly thermal injury is less clear. (biomedcentral.com)
BMMSCs showed significant protective effects on the ultrastructure of DCD donor livers and ROS-induced injury to IAR-20 cells under electron microscopy. (medscimonit.com)
Microvascular ischemia due to congestion causes hepatocellular injury. (medscape.com)

Our findings provide evidence that exosomes from ASCs polarize macrophages toward an M2-like phenotype, which further enhances the exosomal proangiogenic effects. (biomedcentral.com)

Intravenously injected mesenchymal stem cells integrate with the heart after coronary artery occlusion. (anl.gov)
To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. (medscimonit.com)

Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
Nitric oxide-induced suspended animation promotes survival during hypoxia. (harvard.edu)
We have previously reported that TIGAR plays a pro-survival role in cancer cells through increase PPP flux 19 . (nature.com)

NaCN-induced chemical hypoxia is associated with altered gene expression. (harvard.edu)

In the present study, a new neurobehavioral battery of tests was used to characterize the motor performance of newborn pups after sustained hypoxia-ischemia to the preterm rabbit fetus at 67-70% gestation. (jneurosci.org)

However, in spite of their resistance to hypoxia only a small portion of cells survive when transplanted into an infarct scar (6). (escardio.org)

Endometrial ( EN ) and placental ( PL ) morphology and protein synthesis during pregnancy ( PG ) and pseudopregnancy ( PS ) in the cat. (anl.gov)
Mitsugumin 53 (MG53), also known as TRIM72, is a TRIM family protein that was found to be involved in cell membrane repair and primarily found in striated muscle. (biomedcentral.com)
Mitsugumin-53 (MG53), also known as TRIM72, is a cell membrane repair protein that is part of the tripartite motif family of proteins. (biomedcentral.com)
Figure 1: Relationship between protein concentration of lysates from phosphatase-treated and H 2 O 2 -treated C2C12 cells and immediate light generation with chemiluminescent substrate is shown. (cellsignal.com)
BMMSCs also significantly improved the expression level of microtubule-associated protein 1 light chain 3 (LC3)-II in both DCD donor livers and ROS-induced injured IAR-20 cells, including upregulating the expression of ferritin. (medscimonit.com)
Examining the genetic code of these resilient cells revealed that Arctic ground squirrels may have a variant form of a protein called ATP5G1. (elifesciences.org)

Many organisms in nature have evolved mechanisms to tolerate severe hypoxia or ischemia, including the hibernation-capable Arctic ground squirrel (AGS). (elifesciences.org)
Sickle cell anemia (SCA) is the most common and severe form of SCD, resulting from genetic inheritance of HbS genes from both progenitors (SS genotype) 1 . (bvsalud.org)

Hypoxia and ischemia are known to stimulate production of VGEF in some cells. (medscape.com)

By discussing the EMF modulating effects on cell functions, we envisage the use of EMF as a therapeutic agent to regulate immune responses associated with wound healing. (frontiersin.org)
Wound ischemia is thought to be the most common cause of healing failure in a chronic wound. (woundeducators.com)

Immunotherapy with dendritic cells and/or cytokine-induced killer cells for the treatment of hepatocellular carcinoma. (aetna.com)

The levels of nitrite produced in the cultured media of glial cells significantly increased after 12-h hypoxia but not after 0- and 6-h hypoxia. (elsevierpure.com)

M2 macrophages and exosomes from adipose-derived stem cells (ASCs) are both reported to promote angiogenesis. (biomedcentral.com)
Conditioned medium from these M2-like macrophages presented lower levels of proinflammatory cytokines and higher levels of proangiogenic factors and promoted endothelial cell proliferation, migration, and tube formation. (biomedcentral.com)

A ) The coculture system described in Figure 2 was placed in a hypoxia chamber (1% O 2 ) for the indicated times in the presence of 20 pM T4 (free fraction). (jci.org)

The effects depend on frequency, amplitude, and duration of exposure as well as on the characteristics of the targeted cell types. (frontiersin.org)
Noteworthy, in recent years the possibility to use EMF exposure to modulate immune cell responses has been proposed and debated ( 6 - 9 ). (frontiersin.org)
Surprisingly, however, the majority of primed genes were not enriched for H3K4me3 acutely following hypoxia exposure. (frontiersin.org)
The weight-of evidence evaluations are qualitative in nature, although ATSDR recognizes that observations of toxicological interactions depend greatly on exposure doses and that some interactions appear to have thresholds. (cdc.gov)

Anatomy15

Organisms8

Diseases27

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes23

Disciplines and Occupations1

Health Care1

Vitro8

Oxidative11

Reperfusion injury7

Cardiac17

Decreased hypoxia-induced1

Myocardial13

Cardiomyocytes9

Vivo5

Inducible2

Subsequent8

Reoxygenation1

Ischemic2

Models of cerebral1

Hypoxic2

Rats2

Infarction1

Retinal5

Tissue3

Neuronal6

H9c25

Acidosis1

Apoptosis2

Inflammatory8

Vascular4

Glutamate2

Pathway3

Mitochondrial2

Acute3

Oxygen8

Metabolic4

Cardioprotection1

Neurons2

Parkinson's1

Experimental4

Nucleus1

Brain5

Microglia1

Cerebral palsy1

Clinical4

MRNA1

Hypoperfusion1

Induce1

Hepatic2

Myoblasts2

20221

Microcirculation4

Progenitor4

Alzheimer's1

Injury7

Findings provide evidence1

Mesenchymal2

Survival3

Gene expression1

Fetus1

Infarct1

Protein6

Severe2

Stimulate1

Wound2

Hepatocellular1

Significantly increased1

Macrophages2

Chamber1

Exposure4