• We generated GABAergic interneuron precursors from human embryonic stem cells (hESCs) and grafted them in the hippocampi of rats developing chronic SRSs after kainic acid‐induced status epilepticus. (lu.se)
  • [6] In 1885 Wilhelm Roux removed a section of the medullary plate of an embryonic chicken and maintained it in a warm saline solution for several days, establishing the basic principle of tissue culture. (wikipedia.org)
  • In 1907 the zoologist Ross Granville Harrison demonstrated the growth of frog embryonic cells that would give rise to nerve cells in a medium of clotted lymph . (wikipedia.org)
  • skin cells of the mouse into cells strikingly similar to embryonic stem cells, capable of development into a mouse. (brandeis.edu)
  • While regarded by many top scientists as the Holy Grail of medicine, others consider embryonic stem-cell research sacrilegious. (thefutureofthings.com)
  • In the future, embryonic stem cells may be able to restore sight to millions of people. (thefutureofthings.com)
  • As the embryonic cells divide and the daughter cells differentiate, they become increasingly specific. (thefutureofthings.com)
  • The early mammalian embryo consists of the extra-embryonic cell layers-the trophoblast and a body of cells called the inner cell mass (ICM), which eventually become the embryo proper. (thefutureofthings.com)
  • The cells of the ICM are no longer omnipotent, because they no longer share the fate of the trophoblast, and they have committed themselves to an embryonic fate with the ability to become any cell in the body (but not the trophoblast). (thefutureofthings.com)
  • These adult stem cells are considered multipotent, having the ability to differentiate into different cell types, albeit with a more limited repertoire than embryonic stem cells. (thefutureofthings.com)
  • In rodents, and even in some preliminary trials in humans, human embryonic stem cells have been shown to bridge gaps in spinal cord injuries , allowing restoration of motor functions. (thefutureofthings.com)
  • The rest of this article will deal with embryonic stem (ES) cells and the future they hold for modern medicine. (thefutureofthings.com)
  • The chromosomally-arrayed Hox gene family plays central roles in embryonic patterning and the specification of cell identities throughout the animal kingdom. (bvsalud.org)
  • NEW ORLEANS - Retinal pigment epithelial (RPE) cells derived from human embryonic stem cells can be safely transplanted into the eyes of patients with retinal degeneration, with early signs of vision gain, according to pioneers in the field. (medscape.com)
  • Patients had the dry form of age-related macular degeneration (AMD) or Stargardt disease and received injections of human embryonic stem-cell (hESC)-derived RPE cells. (medscape.com)
  • In both studies presented here, human embryonic stem cells were turned into RPE cells and injected into the subretinal space of patients with retinal degeneration at a dose of 50,000 to 200,000 cells. (medscape.com)
  • Human embryonic stem cells have an endless capacity to divide, offer an unlimited source of cells, are capable of becoming any type of cell, and can be differentiated in the laboratory. (medscape.com)
  • Early blastomeres of mouse preimplantation embryos exhibit bi-potential cell fate, capable of generating both embryonic and extra-embryonic lineages in blastocysts. (elsevierpure.com)
  • a single Klf5-overexpressing embryonic stem cell (ESC) generates terminally differentiated embryonic and extra-embryonic lineages in chimeric embryos, and Klf5 directly induces inner cell mass (ICM) and trophectoderm (TE) specification genes. (elsevierpure.com)
  • Researchers at Imperial College London, who developed the model, hope that it will eventually be used by clinicians to advance more effective treatments for sickle cell disease. (news-medical.net)
  • We will talk about sickle-cell disease, eHealth and the impact of the financial crisis on resource mobilization. (who.int)
  • Scholars@Duke publication: Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts. (duke.edu)
  • B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
  • These primitive cells undergo division and differentiation to form the various peripheral blood cells. (nationalacademies.org)
  • Drs. John B. Gurdon, Irving L. Weissman, and Shinya Yamanaka have been pioneers in studying stem cells and the reprogramming of highly differentiated adult cells into pluripotent cells capable of directing differentiation from a single cell to an adult animal. (brandeis.edu)
  • The term stem cell can be defined by two very important qualities: the cell has the ability to self-renew and, in a more general sense, the cell has not completed differentiation into its final state. (thefutureofthings.com)
  • This general definition includes a wide variety of cells with varying degrees of differentiation potential. (thefutureofthings.com)
  • Rebar N. Mohammed Hematopoietic stem cells (HSCs) are a rare population of cells that reside mainly in the bone marrow and are capable of generating and fulfilling the entire hematopoietic system upon differentiation. (karger.com)
  • Furthermore, the human T cell hybridoma cell line MP6 that secretes a B cell growth and differentiation factor, recently identified as an isoform of thioredoxin, is also capable of stimulating EBV-infected B cells and lymphoblastoid cell lines. (lu.se)
  • The effect was relatively specific in that Vpx-associated suppression of soluble IFN-β production, of mRNA levels for ISGs, or of cell surface markers for MDDC differentiation, was not detected. (biomedcentral.com)
  • Recent work , using both in vitro and in vivo models of MN subtype differentiation, have revealed how patterning morphogens and regulation of chromatin structure determine cell -type specific programs of gene expression . (bvsalud.org)
  • Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
  • Transplantation of cells releasing γ‐aminobutyric acid (GABA) could be used to counteract the imbalance between ex-citation and inhibition within epileptic neuronal networks. (lu.se)
  • Smith and Broxmeyer, 1986), thereby making it a potential source of cells for transplantation (Bodger, 1987). (nationalacademies.org)
  • 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
  • Foundation for the Accreditation of Cellular Therapy (FACT) - A non-profit established by the International Society for Cell and Gene Therapy (ISCT) and the American Society for Transplantation and Cellular Therapy (ASTCT) to create and facilitate inspection and accreditation of quality standards for medical and laboratory practice for cellular therapies. (babycenter.com)
  • of graft-versus-host disease, which is observed as a major complication of hematopoietic stem cell transplantation. (karger.com)
  • At a median follow-up of 4 years, the researchers have seen no safety signals related to transplantation of RPE cells. (medscape.com)
  • Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
  • These roles are possible since epithelial cells are non-symmetrical and organized into two opposite poles. (pasteur.fr)
  • How epithelial cells actively respond to mechanical constraints by adjusting how they generate force is important to understand tissue morphogenesis. (nature.com)
  • In the Drosophila embryo, apical constriction in a strip of epithelial cells along the ventral midline results in the folding of the tissue and the internalization of ventral cells, forming a ventral furrow (VF). (nature.com)
  • As the cells reproduce, they commit to a particular task or cell line and become known as committed progenitor cells . (nationalacademies.org)
  • These committed progenitor cells are difficult to discern from the original multipotent cells but can be cultured to form colonies of specific types of blood cells (Guyton and Hall, 2000). (nationalacademies.org)
  • Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
  • Adult stem cells can be used to accelerate bone or tendon healing , and they can induce cartilage progenitor cells to produce a better matrix and repair cartilage damage . (thefutureofthings.com)
  • B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
  • A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)
  • To assist in the study of cellular aging, we established a new method of enriching physiologically aged bone marrow stromal cells (BMSCs) in animals of any age using a Percoll density gradient centrifugation technique. (elsevierpure.com)
  • Xu, F, Zhang, Q & Wang, H 2020, ' Establishing a density-based method to separate proliferating and senescent cells from bone marrow stromal cells ', Aging , vol. 12, no. 14, pp. 15050-15057. (elsevierpure.com)
  • Bone marrow-derived stem cells Hematopoietic stem cells Adipogenesis Fibrin gel culture, 3-dimensional cultures Original Paper Cells Tissues Organs 2008;187:186 198 DOI: 10.1159/000111804 Accepted after revision: August 29, 2007. (karger.com)
  • The cells used are derived from adult tissue such as fat, or bone marrow, thereby circumventing the ethical concerns raised by the use of cells derived from embryos. (ibtimes.com)
  • We're actually developing products now," said Timothy Mayleben, chief executive of Aastrom, which is using cells derived from a patient's own bone marrow to develop treatments for cardiovascular disease. (ibtimes.com)
  • Tissue engineers can choose from a wide range of living cells, biomaterials and proteins to repair a bone defect. (news-medical.net)
  • A new model showing how sickle cell blood cells operate within bone marrow is presented at a conference in Austria today. (news-medical.net)
  • Bone marrow transplants for cancer patients, which rely on blood stem cells, fulfill this potential. (truthdig.com)
  • Many clinics offer stem cells taken from a patient's own bone marrow or fat. (truthdig.com)
  • Metastatic clear cell renal cell carcinoma is a disease without a comprehensive animal model for thorough preclinical investigation. (jove.com)
  • Clear cell renal cell carcinoma or CCRCC, is the most common subtype of kidney cancer. (jove.com)
  • Cells Tissues Organs (2021) 209 (4-6): 209-214. (karger.com)
  • In 2021, both started construction of the Indonesia battery cell JV which is set to start production in the first half of 2024. (hyundai.com)
  • Using whole‐cell patch‐clamp recordings, we characterised the maturation of the grafted cells into functional GABAergic inter-neurons in the host brain, and we confirmed the presence of functional inhibitory synaptic connections from grafted cells onto the host neurons. (lu.se)
  • These data represent a proof‐of‐concept that hESC‐derived GABAergic neurons can exert a therapeutic effect on epileptic animals presumably through establishing inhibitory synapses with host neurons. (lu.se)
  • A particular field encouraged by the foundation is stem-cell research, with the great hope that it will result in the ability to get cells to differentiate into neurons and support cells to bridge the gap of a spinal cord injury. (thefutureofthings.com)
  • Every time we move, feel emotions, think or remember, the nerve cells, or neurons, in our body transmit messages to one another via chemical signals called neurotransmitters. (news-medical.net)
  • Within neurons are tiny organelles called synaptic vesicles that sequester neurotransmitters and release them when needed into the synapse, or space between nerve cells, where the chemical signal is transmitted to other neurons. (news-medical.net)
  • While long-term memory (LTM) is known to be encoded in specific neural cells, engram neurons, it has been unclear how these engram neurons are formed during training. (sciencedaily.com)
  • SEOUL, South Korea , May 26, 2023 /PRNewswire/ -- LG Energy Solution (LGES) and Hyundai Motor Group announced an EV battery cell manufacturing joint venture in the U.S. today. (woodtv.com)
  • In an interim summary of discussions in July 2023, it announced that the selection of priority areas for early adoption of trucks and buses that use fuel cells to run will be finalized before the end of this year. (aseanfun.com)
  • Tumor growth and circulating tumor cells are asset after 10 days of implantation before the embryo hatches. (jove.com)
  • Cancer chemotherapy is based on an understanding of tumor cell growth and how drugs affect it. (medscape.com)
  • Our results show that the murine thymoma cell line EL-4 is superior to peripheral blood mononuclear cells in both cellular outgrowth and cloning experiments, whereas monocyte-derived factors and monocyte cell lines were less capable than peripheral blood mononuclear cells in enhancing cellular outgrowth and cloning. (lu.se)
  • Here we show that Vpx has the extraordinary ability to completely rescue HIV-1 transduction of human monocyte-derived dendritic cells (MDDCs) from the potent antiviral state established by prior treatment with exogenous type 1 interferon (IFN). (biomedcentral.com)
  • Experiments utilizing primary human monocyte-derived macrophages revealed large variability in individual cell responses, ranging from increases in cytokines including TNF-á, to upregulation of complement factors. (cdc.gov)
  • Dr. Irving L. Weissman is professor of pathology and developmental biology at the Stanford University School of Medicine , where he is director of the Institute of Stem Cell Biology and Regenerative Medicine. (brandeis.edu)
  • Shire Plc said in May it planned to establish a new regenerative medicine business, and kick-started it with the $750 million purchase of Advanced BioHealing Inc, which makes a skin substitute for treating diabetic foot ulcers. (ibtimes.com)
  • But this is just a first step in the long road towards making regenerative cell therapy a reality in macular and retinal degeneration. (medscape.com)
  • For more than half a century, the regenerative possibilities of stem cells - which the body stores to repair damaged tissue and organs and restore blood supply - have tantalized the medical community. (truthdig.com)
  • The awards will be given March 26 in a private reception, following a free public symposium entitled "Generation of Pluripotent Stem Cells. (brandeis.edu)
  • These cells are considered pluripotent . (thefutureofthings.com)
  • While some patients in her study have gained vision, Ninel Z. Gregori, MD, from Bascom Palmer Eye Institute, Miami, Florida, said, "These trials show long term safety and possible biologic activity of pluripotent stem-cell derived progeny, but they were not powered to show efficacy. (medscape.com)
  • The 20 patients with poor visual acuity (≤ 20/400) received 50,000 to 200,000 RPE cells, and the six patients with better vision (≤ 20/100) received 100,000 cells. (medscape.com)
  • Over the past three years, GM and Honda have been collaborating on next-generation fuel cell and hydrogen storage systems, aiming at commercialization in the 2020 time frame. (greencarcongress.com)
  • Mass production of fuel cell systems is expected to begin around 2020 and create nearly 100 new jobs. (greencarcongress.com)
  • Established in 2022, CPR Cell Phone Repair Hyattsville is a local electronics repair shop specializing in the repair of the latest iPhone, Mac, Samsung, iPad, and computer models. (local.com)
  • According to a series of 2022 BabyCenter Surveys, which asked parents and parents to be which banks they had used or expected to use, banking parents most often chose CBR to save their newborn's stem cells. (babycenter.com)
  • The Membrane Traffic and Cell Division Laboratory, directed at the Institut Pasteur by Arnaud Echard (Institut Pasteur/CNRS UMR 3691), is looking into apical-basal polarity acquisition mechanisms during cell division when organs are being formed. (pasteur.fr)
  • The laboratory technique of maintaining live cell lines (a population of cells descended from a single cell and containing the same genetic makeup) separated from their original tissue source became more robust in the middle 20th century. (wikipedia.org)
  • NEW YORK (GenomeWeb) - Arcturus Therapeutics this week announced that it has established its own office and laboratory space in San Diego to support its RNA drug discovery and development efforts. (genomeweb.com)
  • His laboratory has also identified human stem cells including human leukemia stem cells that have helped to form the concept of cancer stem cells. (brandeis.edu)
  • Using a 3D in vitro polarity model, scientists have demonstrated full polarity inversion in renal cells deprived of Rab35, whereby the apical domain switches places with the basolateral domain. (pasteur.fr)
  • Photo : spheroid of renal cells cultivated in vitro. (pasteur.fr)
  • It is concluded that establishment of cell lines is possible from the great crested newt, especially when using fresh tissue, but much more challenging if the tissue has been cryopreserved. (au.dk)
  • Cell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. (wikipedia.org)
  • After the cells of interest have been isolated from living tissue , they can subsequently be maintained under carefully controlled conditions. (wikipedia.org)
  • Tissue culture commonly refers to the culture of animal cells and tissues, with the more specific term plant tissue culture being used for plants. (wikipedia.org)
  • In practice, the term "cell culture" now refers to the culturing of cells derived from multicellular eukaryotes , especially animal cells, in contrast with other types of culture that also grow cells, such as plant tissue culture , fungal culture, and microbiological culture (of microbes ). (wikipedia.org)
  • The historical development and methods of cell culture are closely interrelated to those of tissue culture and organ culture . (wikipedia.org)
  • [12] He suggested that the potentialities of individual cells via tissue culture as well as that the reciprocal influences of tissues on one another could be determined by this method. (wikipedia.org)
  • Since Haberlandt's original assertions, methods for tissue and cell culture have been realized, leading to significant discoveries in biology and medicine. (wikipedia.org)
  • The magnitude, direction and timing of contractile force depend on the organization of the cellular actomyosin meshworks and how these networks are connected between cells at the level of the tissue. (nature.com)
  • How cells determine the direction in which they apply force is of critical importance to cell and tissue shape changes. (nature.com)
  • Previous work has shown that gradients or asymmetries in biochemical signals at the cell and tissue level can serve as instructive cues to pattern force generation. (nature.com)
  • FDA Registered - Companies that recover, process, store, distribute, screen, or test cells or tissue must be registered and list its cellular and tissue-based products with the FDA. (babycenter.com)
  • In addition to their ability to supply cells at the turnover rate of their respective tissues, they can be stimulated to repair injured tissue caused by liver damage, skin abrasions and blood loss. (thefutureofthings.com)
  • We used the CliniMACS Plus system located in our Cell and Tissue. (karger.com)
  • The easy accessibility of hematopoietic cells, which are not tightly embedded in tissue, has supported. (karger.com)
  • Greene said that amniotic stem cells derive their healing power from an ability to develop into any kind of tissue, but he failed to mention that mainstream science does not support his claims. (truthdig.com)
  • His demonstration that the expression of four master regulatory genes was sufficient to cause the reprogramming of adult cells has opened up many possibilities for human stem cell therapies. (brandeis.edu)
  • The case sent a chill through the scientific community when it came to light 15 years ago and typifies some of the hurdles researchers have faced while trying to bring stem cell therapies to the market. (ibtimes.com)
  • Therapies tailored to specific genetic lesions and diagnostic tests that assay for their respective molecular targets are now an established part of clinical practice across various tumour types, including chronic myeloid leukaemia 1 , gastrointestinal stromal tumours and epithelial tumours, such as breast and colon cancer 2 . (ersjournals.com)
  • Technically, manufacturers are required to submit stem cell therapies for review as a drug, and to provide evidence of their safety and efficacy, but the U.S. Food and Drug Administration hasn't enforced the rule consistently. (truthdig.com)
  • 1) Membrane Traffic and Cell Division Lab, Cell Biology and Infection Department, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris, France. (pasteur.fr)
  • The cells' apical pole is shown in green and their nuclei in red. (pasteur.fr)
  • Later he showed that differentiated cell nuclei could give rise to fertile adult frogs. (brandeis.edu)
  • Hepatic effects including enlarged centrilobular cells with pale nuclei and dark cytoplasm were observed in males exposed to 150 mglkgiday or more. (cdc.gov)
  • The internalized ventral cells give rise to the mesoderm that differentiates into muscle and other internal cell types such as the fat body, macrophages or lymph glands. (nature.com)
  • We have here examined various cell-derived cytokines for their ability to enhance both the cellular outgrowth of newly infected B cells and the clonability of infected B cells and lymphoblastoid cell lines. (lu.se)
  • In contrast, when therapy with anti-B16 Mab was combined with the administration of C3H lymphokine-activated killer (LAK) cells, which were shown to exhibit antibody dependent cellular cytotoxicity (ADCC) activity, a significant enhancement in the antitumor efficacy of LAK cells was seen. (johnshopkins.edu)
  • This review considers the current evidence linking biomarker profile to efficacy of epidermal growth factor receptor (EGFR)-targeted therapy in advanced nonsmall cell lung cancer (NSCLC) and the clinical implications of recent findings. (ersjournals.com)
  • The measurement of CD4+ T-cell levels has been used to establish decision points for initiating Pneumocystis carinii pneumonia prophylaxis (12) and antiviral therapy (13) and to monitor the efficacy of treatment (14-16). (cdc.gov)
  • cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)
  • Doxorubicin's maximum toxicity occurs during the S phase of cell cycle. (medscape.com)
  • This communication sought to further investigate nanoparticle/cell interactions, ensuing toxicity and cellular responses within biological systems. (cdc.gov)
  • However, more definitive studies regarding specific pathways that are involved with nanoparticle internalization, inflammatory responses and toxicity are warranted before proper guidelines regarding nanoparticle exposure are established. (cdc.gov)
  • Forces that shape cells and tissues can be produced by the contraction of actin filament (F-actin) meshworks by the molecular motor Myosin II (myosin). (nature.com)
  • Here we identify three major two-cell-stage (2C)-specific endogenous retroviruses (ERVs) as the molecular hallmark of this bi-potential plasticity. (elsevierpure.com)
  • Thus, it is critical to understand how cells orient the cytoskeleton to produce forces that deform tissues. (nature.com)
  • Together, our in vivo and in silico data provide a framework for understanding how cells orient force generation, establishing a role for geometrical and mechanical patterning of force production in tissues. (nature.com)
  • The ability of our body to regenerate some of its tissues is largely owed to the reserves of adult stem cells. (thefutureofthings.com)
  • Cells Tissues Organs (2019) 207 (1): 15-20. (karger.com)
  • Cells Tissues Organs (2008) 188 (1-2): 139-149. (karger.com)
  • Cells Tissues Organs (2008) 187 (3): 186-198. (karger.com)
  • Cells Tissues Organs (2005) 180 (4): 195-203. (karger.com)
  • The expectation is that, once in place, the new RPE cells will support or replace the patient's own failing RPE cells and boost the survival of photoreceptors. (medscape.com)
  • Epstein-Barr virus (EBV) is a potent inducer of polyclonal B lymphocyte proliferation and is widely used as a tool for the establishment of B cell lines producing human monoclonal antibodies. (lu.se)
  • We have previously shown that treatment of C57BL/6 mice with specific anti-B16 melanoma monoclonal antibody (Mab) significantly reduced the number of established liver metastases. (johnshopkins.edu)
  • By repetitive learning at intervals, MAPK is activated in the nerve cells to which repetitive information is input, so that a transcription cycle of CREB and c-fos is formed. (sciencedaily.com)
  • In the nerve cells in which the transcription cycle is formed, the amount of CREB increases and it becomes an engram cell in which long-term memory is formed. (sciencedaily.com)
  • Cell culture techniques were advanced significantly in the 1940s and 1950s to support research in virology . (wikipedia.org)
  • Consistent with this, qRT-PCR confirmed that the expression of multiple genes involved in cilia biogenesis was significantly downregulated by diacetyl and 2,3-pentanedione in NHBE cells. (nature.com)
  • Furthermore, immunofluorescence staining showed that the number of ciliated cells was significantly decreased by the flavoring chemicals. (nature.com)
  • Co-cultivation of EBV-infected B cells with MP6 cells significantly enhanced the cloning efficiency at the 1 cell/well level. (lu.se)
  • He was the first to appreciate the therapeutic potential of stem cell therapy and has pioneered its development. (brandeis.edu)
  • A number of large biotech companies and scientists are looking toward stem cells as the basis for a therapeutic solution to cure such illnesses as blindness, diabetes and spinal cord injuries. (thefutureofthings.com)
  • Each of the cell lines also reacted with antibodies against neural cell adhesion molecules, but none of them were positive for antibodies against glial fibrillary acidic protein, keratin, microtubule-associated protein tau and microtubule-associated protein 2, human lymphocyte antigen-DR, epidermal growth factor receptor, and T-cell antigen. (duke.edu)
  • This work therefore describes a new mechanism enabling normal polarity to be established. (pasteur.fr)
  • In the Drosophila thorax, opposing gradients of Dachsous and Four-jointed expression, which are constituents of the Fat/Dachsous/Four-jointed planar cell polarity pathway, result in the polarized localization of the myosin Dachs 9 . (nature.com)
  • In vivo and in vitro models of SAH were established. (nih.gov)
  • As proof-of principle, cells were aged in vitro and confirmed by low bromodeoxyuridine (BrdU) incorporation and senescence-associated β-galactosidase (SA-β-gal) staining. (elsevierpure.com)
  • In 1988 he first identified and isolated the blood-forming stem cells from mice and went on to define the stages of development between the stem cells and differentiated cells of the immune system. (brandeis.edu)
  • Together, these data establish the dual origin of enterovirus ROs and the chronology of their biogenesis at different supporting cellular membranes. (figshare.com)
  • Cellular apoptosis (ie, programmed cell death) is another potential mechanism of many antineoplastic agents. (medscape.com)
  • The drug leads to single-stranded and double-stranded DNA breaks that arrest cellular proliferation in the late S or early G2 phase of cell cycle. (medscape.com)
  • In this way, it was revealed that neuronal cells with high expression of CREB were born, and this cell became engram cells. (sciencedaily.com)
  • FIGURE 2-1 Formation of the multiple peripheral blood cells from multipotent hematopoietic stem cells. (nationalacademies.org)
  • During Drosophila gastrulation, actomyosin contraction in ventral cells generates a long, narrow epithelial furrow, termed the ventral furrow, in which actomyosin fibres and tension are directed along the length of the furrow. (nature.com)
  • Epithelia are layers of cells that cover the surface of our bodies and internal organs. (pasteur.fr)
  • The ICM continues to differentiate into three germ layers-ectoderm, mesoderm and endoderm, each of which follows a specific developmental destiny that takes them along an ever-specifying path at which end the daughter cells will make up the different organs of the human body. (thefutureofthings.com)
  • immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
  • Exploring the potential of human-derived cell lines and glial cell line-derived neurotrophic factor for network inhibition. (lu.se)
  • Establishing cell lines from fresh or cryopreserved tissu. (au.dk)
  • This study describes a successful protocol for establishing cell lines from the threatened Triturus cristatus in terms of collection, preparing, establishing, cryopreserving, thawing and quality checking. (au.dk)
  • Real-time measurements on the cell lines were used, for the first time in amphibian cells, to investigate the effect of different treatments such as media change with or without washing. (au.dk)
  • Immunoreactivities with anti-tenascin and anti-glioma-associated antibodies were variable in these cell lines. (duke.edu)
  • A recent scientific paper published in the journal Microorganisms highlights the development of the first broad range of reptile cell lines, a significant feat that researchers say will help advance reptile conservation. (phys.org)
  • each group of cell lines was established. (lu.se)
  • The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)
  • To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
  • It was found that QDs interact with scavenger receptors, and enter cells via a clathrin coated pit mediated pathway. (cdc.gov)
  • GM and Honda rank No. 1 and No. 3, respectively, in total fuel cell patents filed in 2002 through 2015. (greencarcongress.com)
  • It was established in 2002. (wikipedia.org)
  • Anti-human lymphocyte antigen-A,B and anti-beta 2-microglobulin antibodies reacted with xenografts of D384 Med and D425 Med and were weakly positive for a small population of D384 Med cultured cells. (duke.edu)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • A mid-stage trial from Australia's Mesoblast Ltd showed its stem cell product reduced the rate of heart attacks and the need for artery clearing procedures by 78 percent. (ibtimes.com)
  • The TSERC said all transmission licensee and DISCOMs must constitute a smart grid cell within three months of the regulation being notified. (mercomindia.com)
  • The present results also suggest that one potential role of the MP6-derived thioredoxin could be the up regulation of IL-6 receptor expression in EBV-infected B cells. (lu.se)
  • The principle of preferentially selecting patients most likely to benefit from therapy according to their genetic profile has led to substantial clinical benefit in some tumour types, and has potential to considerably refine treatment in advanced nonsmall cell lung cancer (NSCLC). (ersjournals.com)
  • The purpose of this protocol is to introduce and compare the two animal models recently established for metastatic CCRCC. (jove.com)
  • In blue are the primary cilia ("antennae") leaving the cells via their apical poles. (pasteur.fr)
  • Timm Schroeder Hematopoietic stem cell research has made tremendous progress over the last decades, and blood has become one of the best understood mammalian stem cell systems. (karger.com)
  • LG Energy Solution and Hyundai Motor Group to Establish Battery Cell Manufacturing Joint Venture in the U.S. (woodtv.com)
  • General Motors and Honda are establishing the auto industry's first manufacturing joint venture-Fuel Cell System Manufacturing, LLC, FCSM)-to mass-produce an advanced hydrogen fuel cell system that will be used in future products from each company. (greencarcongress.com)
  • The Fuel Cell System Manufacturing (FCSM) joint venture will be operated by a board of directors consisting of three executives from each company that will include a rotating chairperson. (greencarcongress.com)
  • GM and Honda are acknowledged leaders in fuel cell technology with more than 2,220 patents between them, according to the Clean Energy Patent Growth Index. (greencarcongress.com)
  • These agents inhibit cell growth and proliferation. (medscape.com)
  • After cells divide, they enter a period of growth (phase G1), followed by DNA synthesis (phase S). The next phase is a premitotic phase (phase G2). (medscape.com)
  • The two companies also continue to work with governments and other stakeholders to further advance the refueling infrastructure that is critical for the long-term viability and consumer acceptance of fuel cell vehicles. (greencarcongress.com)
  • Although flow cytometric immunophenotyping is a highly complex technology, methodology for performing CD4+ T-cell determinations has become more standardized between laboratories. (cdc.gov)
  • These findings demonstrate the potential of specific antitumor Mab to affect not only established liver metastases but, when combined with LAK cells that mediate ADCC activity to enhance the eradication of lung metastases as well. (johnshopkins.edu)
  • TANAKA's FC Catalyst Development Center, within its Shonan Plant, is currently developing and manufacturing electrode catalysts for polymer electrolyte membrane fuel cells (PEFCs) and polymer electrolyte water electrolysis (PEWE). (aseanfun.com)
  • A tiny vial no larger than the palm of his hand, he told the group, contains roughly 10 million live stem cells, harvested from the placenta, amniotic fluid, umbilical cord or amnion, the membrane that surrounds the fetus in the womb. (truthdig.com)
  • Next-generation fuel cell stack co-developed by Honda and GM. (greencarcongress.com)
  • The master collaboration agreement announced in July 2013 established the co-development arrangement for a next-generation fuel cell system and hydrogen storage technologies. (greencarcongress.com)
  • The companies integrated their development teams and shared hydrogen fuel cell intellectual property to create a more affordable commercial solution for fuel cell and hydrogen storage systems. (greencarcongress.com)
  • Over the past three years, engineers from Honda and GM have been working as one team with each company providing know-how from its unique expertise to create a compact and low-cost next-gen fuel cell system. (greencarcongress.com)
  • This foundation of outstanding teamwork will now take us to the stage of joint mass production of a fuel cell system that will help each company create new value for our customers in fuel cell vehicles of the future. (greencarcongress.com)
  • The combination of two leaders in fuel cell innovation is an exciting development in bringing fuel cells closer to the mainstream of propulsion applications. (greencarcongress.com)
  • In addition to advancing the performance of the fuel cell system, GM and Honda are working together to reduce the cost of development and manufacturing through economies of scale and common sourcing. (greencarcongress.com)
  • The company has accumulated millions of miles of real-world driving in fuel cell vehicles. (greencarcongress.com)
  • With the next-generation fuel cell system, GM and Honda are making a dramatic step toward lower cost, higher-volume fuel cell systems. (greencarcongress.com)
  • Honda began delivery of its all-new Clarity Fuel Cell vehicle-its third-generation fuel cell vehicle-to US customers in December 2016 following a spring 2016 launch in Japan. (greencarcongress.com)
  • The Clarity Fuel Cell received the best driving range rating from the EPA of any electric vehicle without a combustion engine with a range rating of 366 miles and fuel economy rating of 68 miles per gallon of gasoline-equivalent combined. (greencarcongress.com)
  • Group CEO: Koichiro Tanaka), which operates an industrial precious metals business as a core company of TANAKA Precious Metals, announced today that it has signed a technical assistance agreement with Chengdu Guangming Paite Precious Metal Co., Ltd., an affiliated company in China, in the area of fuel cell electrode catalyst manufacturing technologies. (aseanfun.com)
  • The companies also plan to start production of fuel cell electrode catalysts for the Chinese market by the end of 2025. (aseanfun.com)
  • As a member of TANAKA and with the leading share of the global market for fuel cell electrode catalysts, TANAKA Kikinzoku Kogyo aims to use this agreement to meet the growing domestic demand for fuel cell electrode catalysts in China. (aseanfun.com)
  • PEFCs are used in applications such as fuel cell vehicles (FCVs) and residential-use fuel cells (ENE-FARM), with their use expected to expand in the future to also include buses, trucks, and other commercial vehicles, forklifts and other material handling vehicles, heavy construction machines, robots and other industrial machines, and large stationary equipment. (aseanfun.com)
  • One major issue facing the full-scale use of fuel cell batteries is the cost of the platinum they use. (aseanfun.com)
  • The Chinese government is implementing a range of support measures to promote research and development and the expanded use of fuel cell battery technologies. (aseanfun.com)
  • With other measures, including the development of hydrogen supply infrastructure in cities and along major traffic routes, the country's fuel cell market is expected to grow even further going forward. (aseanfun.com)
  • TANAKA will continue to focus on research and development while working to achieve stable supplies of fuel cell electrode catalysts, and as the leading company in the area of fuel cell electrode catalysts, it aims to contribute toward the expansion of fuel cell use and realization of a hydrogen society. (aseanfun.com)
  • At the top of the list comes the zygote-a fertilized egg, which of course has the ability to divide and differentiate into all cell types in the body and create a new organism. (thefutureofthings.com)
  • In 1962 he made the stunning observation that it was possible to take a differentiated adult cell from a frog and to re-set its genetic program so that the reprogrammed nucleus could be implanted in an enucleated egg and direct the development of tadpoles. (brandeis.edu)
  • Origins of enterovirus replication organelles established by whole-cell electron microscopy. (figshare.com)
  • Whole-cell data sets further revealed striking contact regions between ROs and lipid droplets that may represent a route for lipid shuttling to facilitate RO proliferation and genome replication. (figshare.com)
  • The replication of these viruses within cells relies on specialized membranous structures termed replication organelles (ROs) that form during infection but whose origin remains elusive. (figshare.com)