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  • asymmetric cell div
  • The article "Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus" is by Genetics, Bioinformatics, and Computational Biology graduate student Shenghua Li, research scientist Paul Brazhnik, Professor and Director of VBI's Cyberinfrastructure Group Bruno Sobral, and University Distinguished Professor of Biological Sciences John Tyson. (eurekalert.org)
  • Caulobacter
  • The mathematical model described in the paper allows researchers to study and analyze the systems-level dynamics of the Caulobacter cell cycle, test hypotheses and suggest crucial new experiments. (eurekalert.org)
  • Caulobacter normally undergoes a cell cycle that produces two different types of offspring: a motile "swarmer cell" with a flagellum, a slender thread-like structure that allows the bacterium to swim, and an immobile "sessile stalked cell" that lacks a flagellum. (eurekalert.org)
  • However, prokaryotic cells like Caulobacter have been somewhat neglected as information systems in studies by scientists. (eurekalert.org)
  • mutations
  • Taking this one step further, they were also able to simulate the impact of specific known mutations on cell function. (eurekalert.org)
  • CDC25A
  • CDC25A plays a novel role in regulating the malignant behavior of glioma stem cells as a part of Linc00152/miR-103a-3p/FEZF1/CDC25A axis. (nih.gov)
  • CDC25A is specifically degraded in reaction to DNA damage, which inhibits cells with chromosomal abnormalities from progressing in the course of cell division. (prospecbio.com)
  • In addition, loss of Chk1 resulted in the accumulation of a hypophosphorylated form of the Cdc25A protein phosphatase, and Chk1-deficient cells failed to degrade Cdc25A after IR. (pnas.org)
  • The IR-induced S and G 2 checkpoints were partially restored in Chk1-deficient cells when Cdc25A accumulation was interfered with. (pnas.org)
  • In addition, human Chk1 has been proposed to regulate the stability of the Cdc25A protein phosphatase in UV-damaged cells ( 19 ). (pnas.org)
  • INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest inhibiting CDC25A, CDC25B and CDC25C could help treat breast cancer. (biocentury.com)
  • mathematical model
  • Blacksburg, Va. - Scientists from the Department of Biological Sciences and the Virginia Bioinformatics Institute (VBI) at Virginia Tech have developed a quantitative, mathematical model of DNA replication and cell division for the bacterium Caulobacter crescentus . (eurekalert.org)
  • The mathematical model described in the paper allows researchers to study and analyze the systems-level dynamics of the Caulobacter cell cycle, test hypotheses and suggest crucial new experiments. (eurekalert.org)
  • 2007) A mathematical model of the cell cycle and its circadian control , to appear in Mathematical modeling of Biological Systems, Volume I. A. Deutsch and L. Brusch and H. Byrne and G. de Vries and H.-P. Herzel (eds), Birkhäuser, pp 247-259 proceedings of ECMTB conference, Dresden 2005). (mmnp-journal.org)
  • contributes
  • Evidence that Chk1 contributes to G 2 checkpoint control in human cells comes from studies showing that agents such as UCN-01 and SB-218078, which are potent inhibitors of Chk1, abrogate G 2 checkpoint function in human cells ( 10-12 ). (pnas.org)
  • In this work we describe a mutation in Cdc2 kinase, a pivotal cell cycle control element, and demonstrate that the cell-cycle control mechanism contributes directly to cell-type biases. (concordia.ca)
  • cellular
  • All organisms (single and multi-cellular) rely upon reiteration of growth and division of existing cells under favorable conditions. (antibodies-online.com)
  • It was tempting to study the role of gene expression dynamics in carcinogenesis not only in cultured cells but also in multi-cellular organisms such as animals based on availability of published gene expression profiling data. (omicsonline.org)
  • lung carcinomas
  • Xanthatin functions as a DNA-damaging agent in non-small cell lung carcinomas by activating Chk1-mediated DDR and lysosome-mediated degradation of Cdc25C. (nih.gov)
  • cyclin-depend
  • Both the melanoma cell lines show inactivation of the cyclin-dependent kinase inhibitor gene, CDKN2A/p16INK4A, thus demostrating that this alteration occurs in primary human melanomas. (unicampania.it)
  • Moreover, the inducibility of a pivotal cyclin-dependent kinase inhibitor gene, namely p21CIP1 gene, was obtained by treating the cells with histone deacetylase inhibitors, namely butyrate and phenylbutyrate. (unicampania.it)
  • CDC16
  • We report gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 and APC8/CDC23 (zeige CDC23 Antikörper ) which are known to be key function elements. (antikoerper-online.de)
  • phases
  • The cell cycle is split up into four major phases based on the events unfolding in the cell. (antibodies-online.com)
  • Therefore, the major checkpoint in the cell cycle is the restriction (R) point between G1 and S phases, prior to DNA duplication, at which the cycle progresses depending on mitogenic or inhibitory factors such as DNA damage and signals from various signaling pathways. (antibodies-online.com)
  • Activation of specific cyclin-CDK complexes are characteristic for the different cell cycle phases, and drive production of specific molecules associated with, and necessary for that phase of division. (antibodies-online.com)
  • Analyses by flow cytometry showed the absence of the G2/M peak and the accumulation of cells in G1 and S phases. (unicampania.it)
  • Gene
  • The plant CycD gene family (consisting of CycD1 to CycD4 ) seems to have a special function in communicating external signals to the cells. (plantcell.org)
  • To identify new cancer biomarkers and therapeutic targets for colorectal cancers (CRCs), we performed immunohistochemical analysis using tissue microarrays covering archival tumor tissue samples from 434 CRC patients and antibodies to cell division cycle-associated protein 1 (CDCA1) that was originally identified as an oncoantigen by our gene expression profile database, and compared its expression with several clinicopathological factors. (spandidos-publications.com)
  • Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. (nih.gov)
  • human
  • Human papillomaviruses (HPVs) infect epithelial cells, causing hyperproliferative lesions such as warts and condylomas. (asm.org)
  • Here we show that human cells lacking Chk1 exhibit defects in both the ionizing radiation (IR)-induced S and G 2 checkpoints. (pnas.org)
  • In this study, we investigated the contribution made by human Chk1 to the cell division cycle both in the absence and presence of checkpoint activation. (pnas.org)
  • We report that cells deficient in human Chk1 exhibit radio-resistant DNA synthesis and do not delay in G 2 after IR treatment. (pnas.org)
  • Toward a comprehensive characterization of a human cancer cell phosphoproteome. (nih.gov)
  • OBJECTIVE: On the bases of the above considerations, we decided to establish new cell lines from human melanoma specimens, in order to analyse the molecular alterations in primary preparations of malignant cells. (unicampania.it)
  • mammalian
  • Prior to total disassembly, the Golgi ribbon in mammalian cells, composed of alternating cisternal stacks and tubular networks, undergoes fission of the tubular networks to produce individual stacks. (frontiersin.org)
  • Tyson
  • The article "Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus" is by Genetics, Bioinformatics, and Computational Biology graduate student Shenghua Li, research scientist Paul Brazhnik, Professor and Director of VBI's Cyberinfrastructure Group Bruno Sobral, and University Distinguished Professor of Biological Sciences John Tyson. (eurekalert.org)
  • Cells have some similarities to computers in the sense that they engage in information processing", said Tyson. (eurekalert.org)
  • overexpression
  • Phosphatases and kinases regulating CDC25 activity in the cell cycle: clinical implications of CDC25 overexpression and potential treatment strategies. (nih.gov)
  • Overexpression of Arabidopsis CycD3-1 affects leaf development, leading to curled leaves with an increased number of smaller cells and partial loss of cellu-lar organization ( Meijer and Murray, 2001 ). (plantcell.org)
  • organisms
  • While they are well described for model organisms growing in broth culture, very little is known about the cell division cycle of bacteria replicating in more complex environments. (umass.edu)
  • suggest
  • Several lines of evidence suggest that cell-type biases are directly linked to the cell cycle. (concordia.ca)
  • Approach Summary Licensing status Publication and contact information Drug platforms CD8+ T cells that express phosphopeptide-targeted T cell receptor (TCR) to treat cancer Mouse studies suggest CD8+ T cells expressing TCRs that engage with phosphopeptide. (biocentury.com)
  • melanocortin 1 receptor (MC1R) Cell culture studies suggest targeting the MC1R-cAMP-CDC25B. (biocentury.com)
  • Molecular
  • The title "Cross-Talk between Cell Division Cycle and Development in Plants" was chosen for a workshop hosted by the Instituto Juan March de Estudios e Investigaciones in Madrid (Spain) from November 12 to 14, 2001, and cosponsored by the Institute of Molecular Agrobiology, Singapore, to address the age-old question of whether cells make plants or plants make cells. (plantcell.org)
  • hematopoietic
  • Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence. (nih.gov)
  • completes
  • Accordingly, specific cyclin-CDK complexes persist in an active form for a very short period of time after translation, and are then degraded or inactivated by the time that particular phase of the cell cycle completes. (antibodies-online.com)
  • biases
  • By decreasing the relative proportion of dividing Lm, actin polymerization biases the population toward cells with the highest propensity to form actin tails. (umass.edu)
  • undergoes
  • Caulobacter normally undergoes a cell cycle that produces two different types of offspring: a motile "swarmer cell" with a flagellum, a slender thread-like structure that allows the bacterium to swim, and an immobile "sessile stalked cell" that lacks a flagellum. (eurekalert.org)
  • process
  • Studies of the viral life cycle are important for understanding the process of HPV-induced cancer formation. (asm.org)