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  • donor
  • Perivascular, but not parenchymal, cerebral engraftment of donor cells after non-myeloablative bone marrow transplantation. (sigmaaldrich.com)
  • Therefore, we evaluated the safety and efficacy of donor-derived LMP-Ts in 26 patients who had undergone allogeneic HSCT for EBV-associated natural killer/T-cell or B-cell lymphomas. (bloodjournal.org)
  • In fact, early attempts to decrease treatment related mortality in chronic myelogenous leukemia (CML) patients undergoing allogeneic BMT by T-cell depletion of the graft resulted in an unacceptably high rate of relapse suggesting that alloreactivity in the donor graft accounted for a significant portion of the cure rate in this disease. (knowcancer.com)
  • Fluorescent in situ hybridization for the X and Y chromosomes and karyotype analysis of cultured osteoblasts confirmed the donor origin of these cells and excluded their generation by a fusion process. (pnas.org)
  • further, recent evidence shows that many examples of so-called stem cell developmental plasticity may represent fusions of hematopoietic stem cells with committed progenitors of nonhematopoietic tissues, generating cell hybrids that possess both donor and host genetic information ( 5 - 8 ). (pnas.org)
  • Moreover, in our human cell therapy trials, donor osteoblast engraftment was demonstrated after transplantation of unmanipulated bone marrow ( 14 ), but the percentage of such engraftment could not be improved by transplanting as many as 5 × 10 6 isolated plastic-adherent marrow stromal cells per kg of body weight, a cell number that greatly exceeds the marrow stromal cell content of unmanipulated marrow ( 15 ). (pnas.org)
  • We developed preclinical models of bone marrow transplantation (BMT) for MM using Vk*MYC myeloma-bearing recipient mice and donor mice that were myeloma naive or myeloma experienced to simulate autologous transplantation. (edu.au)
  • Interestingly, donor-derived IL-17A acted directly on myeloma cells expressing the IL-17 receptor to induce a transcriptional landscape that promoted tumor growth and immune escape. (edu.au)
  • Blood, which requires extraction through apheresis, wherein blood is drawn from the donor (similar to a blood donation), and passed through a machine that extracts the stem cells and returns other portions of the blood to the donor. (wikipedia.org)
  • Transplantation research has shown, that donor Tr1 in response to recipient alloantigens, was found to correlate with the absence of GvHD after bone marrow transplantation, while decreased numbers of Tr1 markedly associated with severe GvHD. (wikipedia.org)
  • progenitors
  • One interpretation of these observations is that cells other than those in the adherent population, where mesenchymal stem cells are thought to reside ( 3 ), are potent transplantable progenitors of osteoblasts, consistent with laboratory studies showing that nonadherent cells can give rise to bone ( 12 , 13 , 16 ). (pnas.org)
  • Transplantation with autologous hematopoietic progenitors remains an important consolidation treatment for patients with multiple myeloma (MM) and is thought to prolong the disease plateau phase by providing intensive cytoreduction. (edu.au)
  • At a later stage of brain development, neuroepithelial cells begin to self renew and give rise to non-stem cell progenitors, such as radial glial cells simultaneously by undergoing asymmetric division. (wikipedia.org)
  • The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. (wikipedia.org)
  • Procedure
  • receipt of hematopoietic stem cells "bone marrow" from another individual) is curative for children with severe sickle cell disease, but associated toxicity has made the procedure prohibitive for adults. (eurekalert.org)
  • PBSCT is now a much more common procedure than its bone marrow harvest equivalent, this is in-part due to the ease and less invasive nature of the procedure. (wikipedia.org)
  • The automated red blood cell collection procedure for donating erythrocytes is referred to as 'Double Reds' or 'Double Red Cell Apheresis. (wikipedia.org)
  • stromal cells
  • Pluristem Therapeutics is an Israeli company engaged in the development of human placental adherent stromal cells for commercial use in disease treatment. (wikipedia.org)
  • undergo
  • Cancer patients who undergo stem cell transplantation face two hurdles - lack of white blood cell to fight possible infections and sustaining stem cell function to maintain immunity. (medindia.net)
  • Patients undergo total marrow irradiation (TMI) bid for 3 days. (knowcancer.com)
  • Muse cells do not undergo teratoma formation when transplanted into a host environment in vivo. (wikipedia.org)
  • During the formation of the neural tube, neuroepithelial cells undergo symmetric proliferative divisions that give rise to two new neuroepithelial cells. (wikipedia.org)
  • The neuroepithelial cells undergo two different forms of mitosis: asymmetric differentiating division and symmetric prolific division. (wikipedia.org)
  • differentiate
  • This capacity may solely reflect the activities of multiple discrete stem cells with restricted genetic programs, such as hematopoietic stem cells able to differentiate to leukocytes, erythrocytes, or megakaryocytes and mesenchymal stem cells that can differentiate to bone, cartilage, or adipose tissue ( 3 ). (pnas.org)
  • Alternatively, the bone marrow may contain rare "marrow stem cells" with the potential to differentiate to a spectrum of tissues, possibly in response to specific environmental cues. (pnas.org)
  • Muse cells are shown to home into the damage site and spontaneously differentiate into tissue-compatible cells according to the microenvironment to contribute to tissue regeneration when infused into the blood stream. (wikipedia.org)
  • These neural Stem cells differentiate further into multiple types of cells, like neurons, astrocytes and other glial cells. (wikipedia.org)
  • Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. (wikipedia.org)
  • In a developing embryo, stem cells can differentiate into all the specialized cells-ectoderm, endoderm and mesoderm (see induced pluripotent stem cells)-but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues. (wikipedia.org)
  • Potency: the capacity to differentiate into specialized cell types. (wikipedia.org)
  • Potency specifies the differentiation potential (the potential to differentiate into different cell types) of the stem cell. (wikipedia.org)
  • Totipotent (a.k.a. omnipotent) stem cells can differentiate into embryonic and extraembryonic cell types. (wikipedia.org)
  • Pluripotent stem cells are the descendants of totipotent cells and can differentiate into nearly all cells, i.e. cells derived from any of the three germ layers. (wikipedia.org)
  • Multipotent stem cells can differentiate into a number of cell types, but only those of a closely related family of cells. (wikipedia.org)
  • Oligopotent stem cells can differentiate into only a few cell types, such as lymphoid or myeloid stem cells. (wikipedia.org)
  • Properties of stem cells can be illustrated in vitro, using methods such as clonogenic assays, in which single cells are assessed for their ability to differentiate and self-renew. (wikipedia.org)
  • adipose tissue
  • In 1980-82 his group first identified (and provided an in vitro assay for) the human mesenchymal stem cell - the precursor of bone, cartilage, adipose tissue and smooth muscle. (wikipedia.org)
  • Adipose tissue (lipid cells), which requires extraction by liposuction. (wikipedia.org)
  • relapse
  • Most recently Dr Moore has been studying the cancer stem cell in lung cancer and ovarian cancer and has developed some novel methods for growing human cancer stem cells in vitro allowing extensive molecular analysis and identification of targets for therapy designed to eliminate this rare cell population that is responsible for aggressive tumor growth and relapse. (wikipedia.org)
  • myeloid
  • Cytolitic activity: Tr1 cells can both express Granzyme A and granzyme B. It was shown recently, that Tr1 cells, in vitro and also ex vivo, specifically lyse cells of myeloid origin, but not other APC or T or B lymphocytes. (wikipedia.org)
  • Cytolysis indirectly suppresses immune response by reducing numbers of myeloid-origin antigen presenting cells. (wikipedia.org)
  • HSCs give rise to both the myeloid and lymphoid lineages of blood cells. (wikipedia.org)
  • HSCs constitute 1:10.000 of cells in myeloid tissue. (wikipedia.org)
  • Using the ratio ρ = L / M {\displaystyle \rho =L/M} of lymphoid (L) to myeloid (M) cells in blood as a quantitative marker, the stem cell compartment can be split into three categories of HSC. (wikipedia.org)
  • Balanced (Bala) HSCs repopulate peripheral white blood cells in the same ratio of myeloid to lymphoid cells as seen in unmanipulated mice (on average about 15% myeloid and 85% lymphoid cells, or 3 ≤ ρ ≤ 10). (wikipedia.org)
  • recipients
  • CD8+ T cells from mice with controlled myeloma had a distinct T cell receptor (TCR) repertoire and higher clonotype overlap relative to myeloma-free BMT recipients. (edu.au)
  • Furthermore, T cell-dependent myeloma control could be adoptively transferred to secondary recipients and was myeloma cell clone specific. (edu.au)
  • diseases
  • Its isolation and characterization may suggest novel treatments for genetic bone diseases and bone injuries. (pnas.org)
  • Andrew Louis Pecora (born 1957) is an American hematologist and oncologist who has been involved in the research on the use of stem cells and oncolytic viruses to treat diseases, including cancer. (wikipedia.org)
  • Tr1 cells possess huge clinical potential in means to prevent, block and even cure several T cells mediated diseases, including GvHD, allograft rejection, autoimmunity and chronic inflammatory diseases. (wikipedia.org)
  • stimulates
  • Granulocyte-colony stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. (wikipedia.org)
  • proliferation
  • This can be explained in part by their intrinsically low telomerase activity, eradicating the risk of tumorigenesis through unbridled cell proliferation. (wikipedia.org)
  • The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function. (wikipedia.org)
  • In 1998 the Triebel group showed that, on T cells, LAG-3 down-modulates their proliferation and activation when LAG-3/MHC Class II co-caps with CD3/TCR complex. (wikipedia.org)
  • The neural tube begins as a single layer of pseudostratified epithelial cells, but rapid proliferation of neuroepithelial cells creates additional layers and eventually three distinct regions of growth. (wikipedia.org)
  • Further proliferation of the cells in these regions gives rise to three distinct areas of the brain: the forebrain, midbrain, and hindbrain. (wikipedia.org)
  • Metabolic disruption: Tr1 cells can express ectoenzymes CD39 and CD73 and are suspected of generating adenosine which suppresses effector T cell proliferation and their cytokine production in vitro. (wikipedia.org)
  • Immune
  • Questions concerned with the role of positive and negative selection of developing T cells by peptide-MHC complexes in the thymus in generating an effective and self-tolerant immune system were analyzed in TCR transgenic mice. (wikipedia.org)
  • Presently Harald von Boehmer studies the generation and function of regulatory T cells that have an essential role in preventing autoimmunity with the goal to exploit these cells in the prevention of and interference with unwanted immune reactions. (wikipedia.org)
  • G-CSF is produced by endothelium, macrophages, and a number of other immune cells. (wikipedia.org)
  • adherent
  • Bone marrow was flushed from the dissected femurs and tibias of FVB/N mice (The Jackson Laboratory), and the isolated adherent marrow cells were transduced with a GFP-expressing retroviral vector (multiplicity of infection, ≈5) as described ( 17 ). (pnas.org)
  • regeneration
  • PLX-R18 were initially developed with Prof Raphael Gorodetsky at Hadassah Hospital for the treatment of acute radiation syndrome and enhancement of bone marrow regeneration. (wikipedia.org)
  • 2000
  • LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, is a cell surface molecule with diverse biologic effects on T cell function. (wikipedia.org)
  • PMID
  • Journal of Immunology, 2004 PMID 15494497 Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells. (wikipedia.org)
  • Journal of the American Society of Blood and Marrow Transplantation, 2004 PMID 15205666 Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity. (wikipedia.org)
  • gene
  • We have cloned genomic KL gene and 10kb upstream from the transcription initiation site was analyzed by CAT assay using hematopoiesis supporting stromal cell line ST2. (nii.ac.jp)
  • We found that 35bp upstream of TATA-box is sufficient for assigning CAT-gene expression in this cell line. (nii.ac.jp)
  • As expected, some transgenic mice bearing 2kb or 6kb constructs showed tissue specific expression of LacZ gene in hair follicles, gut pacemaker cells and neurons where KL is expressed. (nii.ac.jp)
  • These phenotypes were unexpectedly linked to mutations in the gene encoding a subunit of the Go-Ichi-Ni-San (GINS) complex, which is essential for DNA replication prior to cell division. (jci.org)
  • Hematopoietic progenitor cell antigen CD34 also known as CD34 antigen is a protein that in humans is encoded by the CD34 gene. (wikipedia.org)
  • As they are stimulated to become plasma cells, B cells refashion parts of their genome in efforts to create a new gene that encodes a functional antibody. (wikipedia.org)
  • If these gene alterations are successful in coding for a functional antibody (termed Ig for immunoglobulin), the maturing B cells and to a greater extent their plasma cell descendants make and secrete an intact antibody, initially IgM but after class switch recombinations, either IgG, IgA, IgE, or IgD. (wikipedia.org)
  • However, the cited gene changes can go awry in plasma cells by, for example, placing a gene that ordinarily controls cell growth adjacent to the normally highly active antibody gene promotor thereby creating a cancer-causing oncogene or, more commonly, by forming extra chromosomes (see trisomy) or chromosomes that have deleted or repetitive sections, any of which such changes may promote malignancy in more complex and less well understood ways. (wikipedia.org)
  • Then in laboratory conditions the stem cells are manipulated and corrected with gene technology. (wikipedia.org)
  • malignant
  • The overproduced Ig's, termed myeloma proteins, commonly circulate in blood, may accumulate in urine, and are the hallmarks of plasma cell dyscrasias including their most malignant forms viz. (wikipedia.org)
  • Malignant infantile osteopetrosis, also known as infantile autosomal recessive osteopetrosis or simply infantile osteopetrosis is a rare osteosclerosing type of skeletal dysplasia that typically presents in infancy and is characterized by a unique radiographic appearance of generalized hyperostosis - excessive growth of bone. (wikipedia.org)
  • Failure of remodeling of the distal femoral and proximal humeral metaphyses giving the affected bones a funnel shaped appearance known as (Erlenmeyer flask deformity) Alternating radiolucent femoral metaphyseal bands Pathologic fractures The differential diagnosis of malignant infantile osteopetrosis includes other genetic skeletal dysplasias that cause osteosclerosis. (wikipedia.org)
  • Neuropathic infantile osteopetrosis Infantile osteopetrosis with renal tubular acidosis Infantile osteopetrosis with immunodeficiency IO with leukocyte adhesion deficiency syndrome (LAD-III) Intermediate osteopetrosis Autosomal dominant osteopetrosis (Albers-Schonberg) Pyknodysostosis (osteopetrosis acro-osteolytica) Osteopoikilosis (Buschke-Ollendorff syndrome) Osteopathia striata with cranial sclerosis Mixed sclerosing bone dysplasia Progressive diaphyseal dysplasia (Camurati-Engelmann disease) SOST-related sclerosing bone dysplasias The only effective line of treatment for malignant infantile osteopetrosis is hematopoietic stem cell transplantation. (wikipedia.org)
  • citation needed] Radiographs of at least one case with malignant infantile osteopetrosis have demonstrated bone remodeling and recanalization of medullar canals following hematopoietic stem cell transplantation. (wikipedia.org)
  • tumors
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • tissues
  • Combining two-photon microscopy with fluorescent tracers, we successfully visualized the engrafted tissues at the single cell level in live mice over several months. (jove.com)
  • Imaging using confocal/two-photon hybrid microscopy enables simultaneous high resolution assessment of uniquely marked cells and their progeny in conjunction with structural components of the tissues. (jove.com)
  • Volumetric analyses over large areas reveal that spectrally coded HSPC-derived cells can be detected non-invasively in various intact tissues, including the bone marrow (BM), for extensive periods of time following transplantation. (jove.com)
  • However, with regard to 42 strains thus far produced , none showed expression in the hematopoietic tissues, except one strain in which LacZ expression was observed in osteoblast cells. (nii.ac.jp)
  • The presence of CD34 on non-hematopoietic cells in various tissues has been linked to progenitor and adult stem cell phenotypes. (wikipedia.org)
  • For years, the concept of harvesting stem cells and re-implanting them into one's own body to regenerate organs and tissues has been embraced and researched in animal models. (wikipedia.org)
  • Genetic
  • Genetic combinatorial marking using lentiviral vectors encoding fluorescent proteins (FPs) enabled cell fate mapping through advanced microscopy imaging. (jove.com)
  • Blood tests include HLA typing (a test of genetic markers on white blood cells that permit specialized immunology studies). (clinicaltrials.gov)
  • Creating female sperm was first raised as a possibility in a patent filed in 1991 by injecting a woman's cells into a man's testicles, though the patent focused mostly on injecting altered male cells into a man's testes (to correct genetic diseases). (wikipedia.org)
  • malignancies
  • FIP1L1-PDGFRA fusion genes have been detected in the eosinophils, neutrophils, mast cells, monocytes, T lymphocytes, and B lymphocytes involved in hemtalogical malignancies. (wikipedia.org)
  • adult T-cell l
  • There is some evidence of a relationship with human T-lymphotropic virus (HTLV) with the adult T-cell leukemia/lymphoma subtype. (wikipedia.org)
  • spermatogenesis
  • During spermatogenesis in mammals and in Drosophila melanogaster, male germ cells develop in a series of essential developmental processes. (jove.com)
  • patient's
  • citation needed] A variation on the Carticel technique, called matrix-associated autologous chondrocyte transplantation (MACT), grows the patient's cells in a 3D matrix of resorbable tissue which is implanted via an open or arthroscopic procedure. (wikipedia.org)
  • severe
  • Since more than one type of immune cell is affected, this disease is classified as a severe combined immunodeficiency disease (SCID). (wikipedia.org)
  • dendritic cell
  • Artykuł zawiera opis dwóch przypadków chorych z rozpoznaniem bardzo rzadko występujących nowotworów z blastycznych plazmacytoidalnych komórek dendrytycznych ( blastic plasmacytoid dendritic cell neoplasms - BPDCN). (czytelniamedyczna.pl)
  • In this paper we report two cases of very rare blastic plasmacytoid dendritic cell neoplasms (BPDCN). (czytelniamedyczna.pl)
  • Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (wikipedia.org)
  • Lymphoma
  • A point-based algorithm for the diagnosis for early forms of cutaneous T cell lymphoma was proposed by The International Society for Cutaneous Lymphomas in 2005. (wikipedia.org)
  • Cutaneous T-cell lymphoma may be divided into the several subtypes. (wikipedia.org)
  • Elorac, Inc. Announces Orphan Drug Designation for Novel Topical Treatment for Pruritus in Cutaneous T-cell Lymphoma (CTCL) website Turgeon, Mary Louise (2005). (wikipedia.org)
  • Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus type 1 (HTLV-I), also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family that has been implicated in several kinds of diseases including very aggressive adult T-cell lymphoma (ATL), HTLV-I-associated myelopathy, uveitis, Strongyloides stercoralis hyper-infection and some other diseases. (wikipedia.org)
  • Adult T-cell lymphoma (ATL) was discovered in 1977 in Japan. (wikipedia.org)
  • Treatment
  • Development of the new methods of treatment of children with acquired and inherited bone marrow failures. (fnkc.ru)
  • Autologous matrix-induced chondrogenesis, which is also known as AMIC, is a biological treatment option for articular cartilage damage bone marrow stimulating technique in combination with a collagen membrane. (wikipedia.org)
  • lipid
  • The lipid outer envelope is of host cell origin but contains viral transmembrane and surface proteins. (wikipedia.org)
  • Volunteers
  • Scientists from the University of Newcastle upon Tyne led by biologist Karim Nayernia discovered a method of creating partly developed sperm cells, otherwise known as "spermatogonial" stem cells, from the bone marrow of male volunteers, entirely in-vitro (outside the human body), and is seeking funding to see whether such techniques can be used to make female sperm. (wikipedia.org)
  • commonly
  • Tests for T cell function: skin tests for delayed-type hypersensitivity, cell responses to mitogens and allogeneic cells, cytokine production by cells Tests for B cell function: antibodies to routine immunisations and commonly acquired infections, quantification of IgG subclasses Tests for phagocyte function: reduction of nitro blue tetrazolium chloride, assays of chemotaxis, bactericidal activity. (wikipedia.org)