AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Bone MarrowBone Marrow CellsBone Marrow TransplantationBone and BonesBone RemodelingBone Marrow DiseasesBone Marrow ExaminationBone Marrow NeoplasmsHematopoietic Stem CellsBone DensityBone ResorptionBone Marrow PurgingHematopoiesisBone NeoplasmsTransplantation, HomologousBone DevelopmentMice, Inbred C57BLBone DiseasesColony-Forming Units AssayCell DifferentiationBone RegenerationCells, CulturedWhole-Body IrradiationTransplantation, AutologousRadiation ChimeraStromal CellsGraft vs Host DiseaseAnemia, AplasticOsteogenesisFlow CytometryLeukemiaBone MatrixBone TransplantationAntigens, CD34GranulocytesSpleenOsteoblastsOsteoclastsHematopoietic Stem Cell TransplantationTransplantation ChimeraMultiple MyelomaPancytopeniaLeukemia, Myeloid, AcuteCell SeparationTime FactorsBone SubstitutesBone Diseases, MetabolicMegakaryocytesMice, KnockoutStem CellsMice, Inbred BALB CCell LineageMyelodysplastic SyndromesFemurImmunophenotypingGranulocyte Colony-Stimulating FactorFractures, BoneT-LymphocytesLeukemia, MyeloidGraft SurvivalMice, TransgenicBone Morphogenetic ProteinsCyclophosphamideBone Morphogenetic Protein 2Mesenchymal Stromal CellsBlood CellsAntigens, CDLeukocyte CountCell CountErythropoiesisCell DivisionBlood Cell CountThymus GlandPrecursor Cell Lymphoblastic Leukemia-LymphomaPrimary MyelofibrosisLeukemia, Myelogenous, Chronic, BCR-ABL PositiveBusulfanChimeraTibiaTissue DonorsTransplantation ConditioningMacrophagesAntibodies, MonoclonalBone CystsPlasma CellsGranulocyte-Macrophage Colony-Stimulating FactorMice, Inbred StrainsColony-Stimulating FactorsHistocompatibility TestingMesenchymal Stem Cell TransplantationTransplantation, IsogeneicCell ProliferationChemokine CXCL12Hematologic DiseasesDisease Models, AnimalHistocompatibilityTreatment OutcomeCell MovementLymphopoiesisAlkaline Phosphatase
TransplantationTransplantAcuteTransplantsBiopsyTumorMultiple myelomaDonorHematopoieticEngraftmentChemotherapyGraftsAntibodiesMalignanciesRelapseLeukemic cellsTissueMononuclear cellsMetastasesApheresisMantle Cell LymSpongyBlood-formCD34PatientsLymphocytesRefractoryProcedureVitroMalignantInfectionImmune cellsDestroySpleenMetastaticProliferationSurvivalTherapeuticPathogensLeukaemiaBody'sBalancesAplasticPhenotypeAbnormalSource of stemTreatmentInfusionCancer cells
Transplantation33
Transplant16
  • Perfosfamide was used experimentally by oncologists in the 1980s for use in bone marrow transplant procedures for treatment of blood cancers. (wikipedia.org)
  • Following that, patients may be eligible for a stem cell transplant, and/or an extended course of immunotherapy that is meant to prolong cancer remission. (rarediseases.org)
  • If confirmed, this would be the first time HIV has been eliminated without a bone marrow or stem cell transplant like the ones that have cured two other men, nicknamed the Berlin and London patients for where they were treated. (wxyz.com)
  • Bone Marrow Transplant. (covalab.com)
  • A bone marrow transplant was her only treatment option. (dartmouth.edu)
  • Stem cell therapy, or stem cell transplant, is a procedure that aims to restore blood-forming stem cells in patients who have undergone chemotherapy or radiotherapy . (parkwaycancercentre.com)
  • Autologous stem cell (patient's own stem cells) transplant is used to help patients recover from the effects of chemotherapy. (parkwaycancercentre.com)
  • Allogeneic stem cell (stem cells from a donor) transplant is used to help patients recover from the effects of chemotherapy and/or radiotherapy as well as to eradicate the remaining cancer cells in the patient after chemotherapy and/or radiotherapy. (parkwaycancercentre.com)
  • Stem cell transplant is often a part of the treatment plan for blood cancers. (parkwaycancercentre.com)
  • In allogeneic stem cell (stem cells from a donor) transplant, there is another benefit in addition to replenishing the HSCs in the bone marrow after chemotherapy or radiotherapy. (parkwaycancercentre.com)
  • The stem cells originate from the patient who will receive the transplant. (parkwaycancercentre.com)
  • A donor, either related or unrelated to the patient, who donates the stem cells for transplant. (parkwaycancercentre.com)
  • Most patients stay in the hospital during this period to be protected from infection and monitored for side effects, though select patients may be candidates for outpatient stem cell transplant . (uchicagomedicine.org)
  • Select patients may receive outpatient stem cell transplant care in specially designed treatment rooms within the unit. (uchicagomedicine.org)
  • Our stem cell transplant physicians are members of the nationally renowned UChicago Medicine Comprehensive Cancer Center , one of only two National Cancer Institute (NCI)-designated Comprehensive Cancer Centers in Chicago. (uchicagomedicine.org)
  • It is officially one year since my bone-marrow transplant (BMT)! (blogspot.com)
Acute6
  • 255 In 1989 Nova Pharmaceutical took over development of the compound and in 1992, it submitted a new drug application to the FDA for using perfosamide to purge malignant cells in transplants for the treatment of acute myeloid leukemia. (wikipedia.org)
  • bone marrow transplants (using a patient's own marrow after it's been purged of cancer cells), but because Kenyon had acute lymphoblastic leukemia, her own marrow would not work. (dartmouth.edu)
  • BACKGROUND: Although in recent years, the introduction of novel chemotherapy protocols has improved the outcome of T cell acute lymphoblastic leukemia (T-ALL) patients, refractory and/or relapsing disease remains a foremost concern. (bvsalud.org)
  • of NK-92 ci against pre-B acute lymphoblastic leukaemia cells. (crispr-reagents.com)
  • While NK-92 is an efficient killer of a wide variety of leukaemia cell types its level of cytotoxicity is definitely least expensive against B-lineage acute lymphoblastic leukaemia (ALL) [5]. (crispr-reagents.com)
  • The predominant cells of pus, neutrophils are the hallmark of acute inflammation. (ishinobu.com)
Transplants7
  • The cause was a return of the cancer that originally prompted the unusual bone marrow and cell transplants Brown received in 2007 and 2008, which for years seemed to have eliminated both his leukemia and HIV, the virus that causes AIDS. (wxyz.com)
  • Frequently, stem cells are taken from the pelvic bone, filtered, and stored under special conditions for future transplants. (parkwaycancercentre.com)
  • Additionally, stem cell transplants can also be categorised based on who donates the stem cells. (parkwaycancercentre.com)
  • Citation: Mera T, Heimfeld S, Faustman DL (2014) The Spleen Contributes Stem Cells to Peripheral Blood Stem Cell Transplants. (fliphtml5.com)
  • Interestingly, thiscell transplants (PBSCTs) from donors given granulocyte-colony- immature peripheral phenotype was similar to bone marrow transplantsstimulating-factor (G-CSF) has decreased relapse rates and improved before G-CSF. (fliphtml5.com)
  • Our hypothesis about a splenic stem cell contributionor maintained survival compared to bone marrow transplants, to PBSCT also derives from the observation that G-CSF mobilizationsalthough graft versus host disease (GVHD) still occurs [1]. (fliphtml5.com)
  • For induce splenomegaly in most donors and in rare, severe cases splenicautologous stem cell transplants, the use of autologous PBSCT from rupture [13,14]. (fliphtml5.com)
Biopsy5
Tumor8
  • Results Using the 5TGM1-Kalw/RijHSD immunocompetent in vivo model we have demonstrated that reovirus reduces both MM tumor burden and myeloma-induced bone disease. (bmj.com)
  • Moreover, increased effector-memory CD8 + T cells correlated with decreased tumor burden. (bmj.com)
  • Multiple myeloma (MM) is a tumor of terminally differentiated plasma cells which expand in the bone marrow (BM). (bmj.com)
  • Bioreductive agents, such as Tirapazamine (TPZ), are preferentially cytotoxic in hypoxia and show activity against a variety of tumor cell lines ( 1 - 4 ). (aacrjournals.org)
  • Diagnosis: Refractory or relapsed neuroblastoma with original diagnosis based on tumor histopathology or elevated urine catecholamines with typical tumor cells in the bone marrow. (ucsf.edu)
  • Patients with granulocytopenia and/or thrombocytopenia due to tumor metastatic to the bone marrow may be eligible after discussion with study chair or designee. (ucsf.edu)
  • Recently, stem cells are being engineered to carry therapeutic reagents to target tumor sites. (bmrat.org)
  • In this in vivo study, we monitor the real-time and long-term dynamics of circulating tumor cells (CTCs) after a single round of PDT and after surgical resection in a breast cancer animal model. (kanker-actueel.nl)
Multiple myeloma3
Donor9
  • It was added to the tissue after it had been taken from the donor but before the tissue was administered to the patient to "purge" lymphocytes in order to prevent Graft Versus Host Disease, which results from donor lymphocytes attacking normal host cells and tissues, and to "purge" a patient's own (autologous) collected hematopoietic stem cells of any malignant cells it may still contain at the time of harvesting. (wikipedia.org)
  • This way of making iPSCs from adult cells circumvents the need to destroy an embryo from living donor. (bmrat.org)
  • The donor immune cells can kill the leftover cancer cells and will exert a "graft-versus-cancer" effect, keeping the cancer cells in check. (parkwaycancercentre.com)
  • Finding a donor with suitable stem cells is critical to avoid graft rejection or graft-versus-host syndrome. (parkwaycancercentre.com)
  • Many factors dictate whether the donor stem cells are suitable for the recipient but the most important one is the human leukocyte antigen (HLA) system. (parkwaycancercentre.com)
  • eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
  • Bone marrow stem cells are harvested from the donor in an operating room. (uchicagomedicine.org)
  • She said, "Your marrow looks fabulous and you are 100% donor. (blogspot.com)
  • Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor. (bvsalud.org)
Hematopoietic7
  • 131I-MIBG is active against relapsed or refractory neuroblastoma and associated hematopoietic toxicity can be abrogated with autologous stem cell rescue. (ucsf.edu)
  • 6 months previous and if the patient has adequate hematopoietic stem cells available and if cumulative 131I-MIBG dose will not exceed 60 mCi/kg. (ucsf.edu)
  • All of the blood cells in the body come from immature cells called hematopoietic stem cells, HSCs (hematopoietic means blood-forming). (parkwaycancercentre.com)
  • To overcome this problem, methods of ex vivo treatment ('purging') of autologous marrow must be developed that optimally eradicate AML cells but spare normal hematopoietic stem cells. (arizona.edu)
  • CFU-Leuk), which we have shown are predictive for hematopoietic engraftment and AML log-kill in rats given syngeneic marrow and/or AML cells incubated ex vivo with selected chemotherapeutic agents, will be used in these dose-response studies. (arizona.edu)
  • After incubation, cells will be plated for CFU-GM and CFU-Leuk assays to determine survival of committed hematopoietic progenitors and log-kill of AML cells, and optimal conditions for antileukemic effect with stem-cell sparing. (arizona.edu)
  • G-CSF mobilizesCD34+ hematopoietic stem cells from bone marrow into the blood. (fliphtml5.com)
Engraftment3
  • We also found that, after CD2 stimulation, calcium flux in T cells was normal immediately after engraftment. (ashpublications.org)
  • We conclude that despite the recovery of normal numbers of T lymphocytes early after engraftment of CD6-depleted marrow, these T cells exhibit several physiologic and functional abnormalities that persist for varying intervals post-BMT. (ashpublications.org)
  • Engraftment and recovery - transplanted stem cells begin to grow and reproduce healthy blood cells. (uchicagomedicine.org)
Chemotherapy8
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
  • Chemotherapy or radiotherapy used to treat these cancers will destroy the HSCs in the bone marrow and abolish the body's ability to regenerate blood cells. (parkwaycancercentre.com)
  • The patient first receives a high dose of chemotherapy and/ or radiotherapy to eliminate the remaining cancer cells in the body. (parkwaycancercentre.com)
  • The recommended dose is 250 mcg/m2/day administered IV over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. (wikidoc.org)
  • The chemotherapy increased the number of senescent cells in the mice. (newportnaturalhealth.com)
  • In another experiment, a week after they had received chemotherapy, mice were given a drug that kills senescent cells. (newportnaturalhealth.com)
  • Conditioning treatment - administration of chemotherapy and/or radiation to the patient in order to destroy all of the diseased cells in the body and to create space in the bone marrow for the transplanted stem cells to populate. (uchicagomedicine.org)
Grafts1
  • In the present study, we examined immune function after BMT in a series of patients who had received HLA compatible sibling marrow grafts purged of T cells with anti-CD6 monoclonal antibody and complement. (ashpublications.org)
Antibodies9
  • The hybridoma cells literally exploded in the hands of Otto and I don't know anyone who made more monoclonal antibodies than he. (meduniwien.ac.at)
  • Legendary antibodies are for instance the CD15 monoclonal antibody VIM-D5 and the CD65 monoclonal antibody VIM-2, the first tools in 1980 to recognize myeloid blood cells. (meduniwien.ac.at)
  • Otto's monoclonal antibodies closed many gaps in understanding the development and differentiation of immune and blood cells. (meduniwien.ac.at)
  • With the biological process of monoclonal antibodies (mabs),there has been an change in remove prison cell motley (e. (pendletonwebdesign.biz)
  • PHA) or antibodies to the CD2 surface structure (anti-T11(2) + anti-T11(3)) results in decreased levels of T-cell proliferation compared with controls for over 18 months post-BMT. (ashpublications.org)
  • In contrast, after stimulation with anti-CD3 antibodies, a large population of T cells do not develop intracellular calcium flux compared with controls. (ashpublications.org)
  • B cells produce antibodies: tags that stick to pathogens, marking them for destruction. (ishinobu.com)
  • The pony's resistant framework responds to these cells and makes antibodies that can obliterate them. (rizochem.com)
  • These antibodies are gathered and purged to maker-ATG. (rizochem.com)
Malignancies3
  • Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)
  • An effective immunomagnetic method for bone marrow purging in T cell malignancies. (covalab.com)
  • TheIntroduction later step is unique to splenic function since splenectomy results in similar accumulations of naïve B cells, reduction of memory B cells and Treatment of malignancies with allogeneic peripheral blood stem well-known susceptibilities to select infections [12]. (fliphtml5.com)
Relapse1
  • We then studied the combination of nelarabine with the PI3K inhibitors (both pan and dual γ/δ inhibitors), with the Bcl2 specific inhibitor ABT199, and with the MEK inhibitor trametinib on both T-ALL cell lines and patient samples at relapse, which displayed constitutive activation of PI3K signaling and resistance to nelarabine alone. (bvsalud.org)
Leukemic cells2
  • However, the presence of residual occult viable leukemic cells in the marrow autograft limits the therapeutic effectiveness of ABMT in AML. (arizona.edu)
  • Hopkins Oncology Center (JHOC), Baltimore, MD, will evaluate novel ex vivo marrow purging regimens by comparison of the effects of incubation with graded concentrations of immunologic and/or pharmacologic agents on the growth of normal marrow and leukemic cells, using an authentic animal model of human AML (the LBN hybrid rat). (arizona.edu)
Tissue7
  • Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. (rarediseases.org)
  • Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
  • The European Calcified Tissue Society (ECTS) is the premier bone research society in Europe. (meduniwien.ac.at)
  • 131I-metaiodobenzylguanidine (131I-MIBG) is a norepinephrine analog that concentrates in adrenergic tissue and therefore holds promise for cell-specific treatment of neuroblastoma. (ucsf.edu)
  • Those are due to the unique characteristics of stem cells, such as immunological tolerance, migration, and tissue reparation. (bmrat.org)
  • Stem cells continue to play a role in repairing damaged tissue and replacing cells that are lost every day. (bmrat.org)
  • So senescent cells can not only do some very serious damage to surrounding tissue. (newportnaturalhealth.com)
Mononuclear cells4
  • Methods This study used human peripheral blood mononuclear cells from healthy donors and in vitro co-culture of MM cells and BM stromal cells to recapitulate the resistant BM niche. (bmj.com)
  • At least 6.5 x 10(8) [corrected] mononuclear cells/kg patient weight were collected from the peripheral blood of each patient, cyropreserved, and returned intravenously following CBV administration. (shengsci.com)
  • 2.0 x 10 8 mononuclear cells/kg). (ucsf.edu)
  • In contrast, the ability of unstimulated peripheral blood mononuclear cells (PBMC) to respond to recombinant interleukin-2 (rIL-2) is relatively intact, most likely reflecting early functional reconstitution of the NK cell population. (ashpublications.org)
Metastases3
  • The 30 patients who had no marrow metastases at the time of PSC harvesting had an actuarial event-free survival of 47%, while those 26 patients with marrow metastases had a significantly different actuarial event-free survival of 27% (P = .02). (shengsci.com)
  • CBV and PSCT for patients with relapsed Hodgkin's diseases who have marrow hypocellularity in traditional harvest sites or histopathologic evidence of BM metastases can result in long-term event-free survival. (shengsci.com)
  • The recurrence, which presented with multiple metastases in the bone marrow, occurred 2 years after PBSCT (Figure 1 A). At this time, VAM and HVA had increased to 273.5 and 87.7 μg/mg Cr, respectively. (biomedcentral.com)
Apheresis1
Mantle Cell Lym3
  • Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
  • Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
  • Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, which is a form of cancer that affects the lymphatic system. (rarediseases.org)
Spongy1
Blood-form1
  • Blood-forming stem cells are indispensable because they can grow into different blood cells - they are the body's "building block" that can mature into any type of blood cell with specialised functions. (parkwaycancercentre.com)
CD342
  • G. , cd34+cells) and purge of infixs (e. (pendletonwebdesign.biz)
  • Enrichment of PBSCT by purification of CD34+stem cells fails to produce superior clinical benefits. (fliphtml5.com)
Patients8
  • 131I-MIBG given in doses of 10-18 millicurie (mCi)/kg with stem cell rescue, if necessary, is safe and effective palliative therapy for refractory or relapsed neuroblastoma patients. (ucsf.edu)
  • For a long time, stem cells have been utilized to renew the immune system for radiation or chemo- therapy treated patients. (bmrat.org)
  • Additionally, patients do not need to undergo the bone marrow procedure under sedation. (parkwaycancercentre.com)
  • The idea of this procedure is to "reset" the immune system by purging patients of their bone marrow cells, and then returning healthy bone marrow to them. (translationalethics.com)
  • Patients should not receive Sargramostim until the post marrow infusion ANC is less than 500 cells/mm3. (wikidoc.org)
  • It's pretty clear by now that purging senescent cells might help guard against unpleasant side effects among chemo patients. (newportnaturalhealth.com)
  • Further, clinically insignifi cant colonization or con- tronically purged of the names of patients with positive HIV tamination can be diffi cult to distinguish from true disease, serologic test results, patients with HIV viral load, and pa- tients who had had genotyping studies performed. (cdc.gov)
  • Patients with CLL have a higher-than-normal white blood cell count, which is determined by complete blood count (CBC). (medscape.com)
Lymphocytes8
  • Lymphomas are cancers that involve white blood cells, and can be divided depending on the type of cell involved, either B-lymphocytes or T-lymphocytes. (rarediseases.org)
  • MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
  • MM cells co-cultured with BM stromal cells displayed resistance to reovirus-induced oncolysis and bystander cytokine-killing but remained susceptible to killing by reovirus-activated NK cells and MM-specific cytotoxic T lymphocytes. (bmj.com)
  • Recent studies have shown that soluble factors elaborated by human T lymphocytes enhance erythroid burst formation by human peripheral blood null cells. (shengsci.com)
  • Despite the return of normal numbers of T lymphocytes post-BMT phenotypic analysis reveals several long-term abnormalities, including an inverted T4:T8 ratio and a significant fraction of CD3+ T cells that do not co-express CD6. (ashpublications.org)
  • Kills off and repels pathogen cells, while also helping to strengthen lymphocytes so the immune system can fight off pathogens. (medicalmedium.com)
  • Possesses immune-system-enhancing nutrients that revitalize white blood cell count by increasing the production of lymphocytes, monocytes, neutrophils, basophils, and eosinophils, so that your body can battle invaders. (medicalmedium.com)
  • ATG works by eliminating explicit cells in your safe framework called T-lymphocytes, the phones that assault bone marrow foundational microorganisms in aplastic paleness. (rizochem.com)
Refractory1
  • METHODS: The effectiveness of nelarabine as single agent or in combination with PI3K, Bcl2, and MEK inhibitors was evaluated on human T-ALL cell lines and primary T-ALL refractory/relapsed lymphoblasts. (bvsalud.org)
Procedure1
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
Vitro3
  • By coupling efficient chemical synthesis routes to multiple upfront in parallel phenotypic screens, we identify that KBU2046 inhibits cell motility and cell invasion in vitro. (nature.com)
  • Efficacy of KBU2046 is demonstrated across several different in vitro models and across multiple murine models of human cancer metastasis, which includes decreased metastasis, decreased bone destruction, and prolonged survival. (nature.com)
  • Variables to be examined include agent concentrations, incubation duration and temperature, cell density, sequence of treatment, and number of cycles of in vitro treatment. (arizona.edu)
Malignant4
  • A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. (curehunter.com)
  • The usage of NK cells in adoptive therapy for malignant disease can be an specific section of great potential. (crispr-reagents.com)
  • extended cytotoxic cells can be an specific section of extensive investigation for the treating malignant disease. (crispr-reagents.com)
  • Based on the high cytotoxic activity and specificity for malignant cells possessed by NK-92 medical trails have opened to evaluate the feasibility of using this collection for adoptive transfer therapy [8]. (crispr-reagents.com)
Infection1
Immune cells2
  • Vitamin C feeds immune cells so they can fight free radical toxins. (medicalmedium.com)
  • CWRU's Sékaly Finds HIV Reservoir Vulnerability Today the Case Daily published an article about exciting developments in purging the reservoir of infected immune cells in people living with HIV, research conducted by our CFAR colleague Rafick-Pierre Sékaly. (clevelandhiv.org)
Destroy4
  • This high-dose therapy will also destroy the HSCs in the bone marrow. (parkwaycancercentre.com)
  • To detect and destroy microbial invaders, an immune system covers 2 territories: cells and the extracellular pathways of the body, including the circulatory system. (ishinobu.com)
  • Helps destroy and purge pathogens from the body, helping the immune system to win the war on invaders. (medicalmedium.com)
  • Photodynamic therapy (PDT) for cancer is based on a photochemical process of photosensitizers that concentrate in tumors and release oxidant species under light excitation to destroy cells. (kanker-actueel.nl)
Spleen5
  • Many affected individuals have widespread disease at diagnosis, with involved regions often including multiple lymph nodes, the spleen, and, potentially, the bone marrow, the liver, and/or regions of the digestive (gastrointestinal) tract. (rarediseases.org)
  • We hypothesize that the reason why CD34+-enriched PBSCTsare not more effective is because the enrichment and purification process leaves out G-CSF-mobilized stem cells fromanother source, the spleen, which holds a unique reservoir of Hox11+ stem cells. (fliphtml5.com)
  • The findingssupport the hypothesis that G-CSF mobilizes two distinct stem cell populations, one from the bone marrow andthe other from the spleen. (fliphtml5.com)
  • The spleen also uniquely contributes toGraft Versus Host Disease (GVHD) complete B cell memory [11]. (fliphtml5.com)
  • The stem cells of the spleen allow for full maturation of immature transitional B cells into naive B cells. (fliphtml5.com)
Metastatic2
  • It is required in order for cells to invade through the basement membrane, represents an initial step in the metastatic cascade, and is necessary for cells to move from their primary organ of origin to distant metastatic sites. (nature.com)
  • Circulating PSA-positive cells are also strongly associated with metastatic prostate cancer [ 8 ]. (hindawi.com)
Proliferation3
  • To further characterize the prolonged abnormalities in T-cell proliferation after PHA or CD2 stimulation, we examined more proximal events in T-cell activation such as induction of IL-2 receptor expression and stimulus-induced intracellular calcium flux. (ashpublications.org)
  • Splenomegaly might reflect dramatic G-CSF-inducedG-CSF stimulation also in multiple studies shows faster recovery of Hox11+ stem cell proliferation. (fliphtml5.com)
  • MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
Survival3
  • Across three different murine models of human prostate and breast cancer, KBU2046 inhibits metastasis, decreases bone destruction, and prolongs survival at nanomolar blood concentrations after oral administration. (nature.com)
  • The combination with the pan PI3K inhibitor ZSTK-474 was the most effective in inhibiting the growth of T-ALL cells and was synergistic in decreasing cell survival and inducing apoptosis in nelarabine-resistant T-ALL cells. (bvsalud.org)
  • NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
Therapeutic3
  • We identify a unique cell motility regulatory mechanism and synthesize a targeted therapeutic, providing a platform to pursue studies in humans. (nature.com)
  • Processes that drive the development of increased cell motility represent high-value therapeutic targets. (nature.com)
  • We hypothesized that we could use them to identify novel and selective sites that regulate cancer cell motility and that such sites would constitute high-value therapeutic targets. (nature.com)
Pathogens2
  • Granulocyte chemicals facilitate many functions, including purging pathogens. (ishinobu.com)
  • Strengthens the entire immune system, especially the killer cells that go after pathogens such as EBV, shingles, and flus. (medicalmedium.com)
Leukaemia2
  • Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)
  • Significantly treatment of the badly killed leukaemia cells with TNF-α augmented both -independent and phosphoinositide-dependent cytolysis. (crispr-reagents.com)
Body's1
  • Other leads have come from imaging technology that traces the activity of T cells, a type of white blood cell, which are part of the body's main antiviral immune response. (ksut.org)
Balances2
  • 2. Scaler Wave technology energizes cells, balances body systems, strengthens the body, and promotes deeper penetration. (yummy.doctor)
  • Also strengthens red blood cells and bone marrow, balances blood platelets, and staves off cytokine storms. (medicalmedium.com)
Aplastic2
Phenotype1
Abnormal1
Source of stem1
Treatment6
  • Stem cells are not only widely used for regenerative medicine, but are also considered as a useful tool for cancer treatment. (bmrat.org)
  • Cancer vaccines based on the knowledge of cancer stem cells have been studied and applied for cancer treatment. (bmrat.org)
  • The treatment helps to restore damaged blood cells such as red blood cells, white blood cells, and platelets. (parkwaycancercentre.com)
  • RESULTS: Treatment with nelarabine as a single agent identified two groups of T-ALL cell lines, one sensitive and one resistant to the drug. (bvsalud.org)
  • 123 I-MIBG accumulation decreased after treatment in the parietal bone and humerus (black arrows), but it was still detected in the thoracic vertebrae and femur (white arrows). (biomedcentral.com)
  • Sargramostim treatment should be interrupted or the dose reduced by half if the ANC exceeds 20,000 cells/mm3. (wikidoc.org)
Infusion1
Cancer cells1
  • The efficacy and specificity of CRAD on prostate cancer cells were examined in cell culture and animal models. (hindawi.com)