Cells apolipoprotein b 100. Medical search. Frequent questions

Dive into the research topics of 'Novel small molecule therapeutics for sickle cell disease: nitric oxide, carbon monoxide, nitrite, and apolipoprotein A-I.'. Together they form a unique fingerprint. (johnshopkins.edu)

Atheroprotection was also documented in apoe(-/-) mice lacking functional transforming growth factor-beta receptors on T cells. (lu.se)
What is also clear is that the ApoB on the LDL particle acts as a ligand for LDL receptors in various cells throughout the body (i.e., less formally, ApoB indicates fat-carrying particles are ready to enter any cells with ApoB receptors and deliver fats carried within into the cells). (wikipedia.org)
Our analysis emphasizes the relevance of the specific ligands, receptors and cell types regulating these processes. (nature.com)
Apolipoprotein B-100 allows LDLs to attach to specific receptors on the surface of cells, particularly in the liver. (medlineplus.gov)
Once attached, the receptors transport LDLs into the cell, where they are broken down to release cholesterol. (medlineplus.gov)
The altered protein prevents LDLs from effectively attaching to their receptors on the surface of cells. (medlineplus.gov)
Apo B is necessary for the reaction with LDL receptors in the liver and on cell walls, and is thus involved in transporting cholesterol from the liver to the vessel cell. (cdc.gov)

Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. (hindawi.com)
Lipid metabolism in the epidermis may be regulated by the expression of apolipoprotein E (APOE), a glycoprotein which is synthesized in a wide variety of extrahepatic tissues including skin [ 27 - 29 ]. (hindawi.com)
In ApoE-/- mice, immunization with P210-PAMs dampened P210-specific CD4+ T cell proliferative response and CD8+ T cell cytolytic response, modulated macrophage phenotype, and significantly reduced aortic atherosclerosis. (jci.org)
Genetic and biochemical studies support the apolipoprotein E ( APOE ) ε4 allele as a major risk factor for late-onset Alzheimer's disease (AD), though ~50% of AD patients do not carry the allele. (biomedcentral.com)
To date, only four genes have been unambiguously associated with AD, of which only one, Apolipoprotein E ( APOE ), is associated with the common, late-onset form of AD [ 1 ]. (biomedcentral.com)
Objective - Apolipoprotein E (apoE) reduces mouse atherosclerosis progression independent of plasma cholesterol level effects. (mssm.edu)
In addition, foam cell content of the neointima and media of injured arteries, a negative prognostic indicator in postangioplasty human lesions, was inversely related to plasma apoE levels. (mssm.edu)
Many human lung cancer cell lines express apolipoprotein E (ApoE), especially cells derived from malignant pleural effusions (MPE) in patients with lung adenocarcinoma. (ncku.edu.tw)
Next, we examined the roles of ApoE in an MPE-derived lung adenocarcinoma cell line that endogenously over-expresses ApoE, PC14PE6/AS2 (AS2). (ncku.edu.tw)
In that experiment we inhibited ApoE expression by transfection of a plasmid carrying ApoE siRNAs into AS2 cells to generate AS-S2 and AS-S3 cells. (ncku.edu.tw)
The major apolipoproteins (apo) on human cerebrospinal fluid lipoproteins are apoA-I and apoE. (elsevierpure.com)
Given the association between inheritance of the ε4 allele of the apoE gene (APOE4) and increased susceptibility to Alzheimer's disease, we tested the hypothesis that cerebrospinal fluid apolipoproteins may be influenced by APOE genotype and Alzheimer's disease. (elsevierpure.com)
The relative levels of apoE- and apoA-II-containing apolipoproteins correlated with APOE genotype but were not altered by Alzheimer's disease. (elsevierpure.com)
These differences in cerebrospinal fluid apolipoproteins may influence lipoprotein trafficking and may be an element in the stratification of risk for Alzheimer's disease with APOE genotype. (elsevierpure.com)
After injection of PVT1 -silencing lentiviruses, AAA was induced in Apolipoprotein E-deficient (ApoE −/− ) male mice by angiotensin II (Ang II) infusion for four weeks. (molcells.org)

Conclusion-Nasal administration of an apoB-100 peptide fused to CTB attenuates atherosclerosis and induces regulatory Tr1 cells that inhibit T effector responses to apoB-100. (lu.se)
Active immunization with the apolipoprotein B-100 (ApoB-100) peptide P210 reduces experimental atherosclerosis. (jci.org)
Apolipoprotein E: possible therapeutic target for atherosclerosis. (elsevierpure.com)
Dive into the research topics of 'Apolipoprotein E: possible therapeutic target for atherosclerosis. (elsevierpure.com)

ApoB-100 is the largest of the apoB group of proteins, consisting of 4563 amino acids. (wikipedia.org)
Western Blot: SR-BI Antibody [NB400-104] - Detection of SR-BI in rat H4IIE total cell lysates and plasma membrane proteins. (novusbio.com)
All NTs are also found to associate a common subset of proteins including albumin, titin, and apolipoproteins. (njit.edu)
Moreover, it was proposed that Clusterin functions as an extracellular chaperon that stabilizes stressed proteins in a folding-competent state, and that the protein is involved in programmed cell death. (biovendor.com)
Evidences have suggested that proteins primarily related to plasma lipoprotein transport, such as apolipoprotein (apo) CIII and E, may significantly affect the process of body fat accumulation. (biomedcentral.com)
Along her career, she has applied scattering techniques to characterize the multi-scale architecture of plant cell walls, bacterial cellulose model systems, polysaccharides extracted from a variety of biomass sources (e.g. seaweeds, microalgae, agroindustrial waste, etc.), food proteins and food packaging materials. (lu.se)

Apolipoprotein B is the primary apolipoprotein of chylomicrons, VLDL, Lp(a), IDL, and LDL particles (LDL-commonly known as "bad cholesterol" when in reference to both heart disease and vascular disease in general), which is responsible for carrying fat molecules (lipids), including cholesterol, around the body to all cells within all tissues. (wikipedia.org)
In the peripheral tissues, particularly adipose and muscle tissue, VLDL is cleaved by lipoprotein lipase (LPL), extracting most of the triglycerides and forming an IDL that contains apoproteins B-100 and E. IDL can be taken up by the liver through the LDL receptor, or it can be converted to the cholesterol-rich LDL that contains apoprotein B-100. (medscape.com)
Cholesterol is bound to apolipoprotein B-100 as LDL in interstitial fluid. (medscape.com)
Cells may acquire cholesterol via an LDL receptor on the cell membrane. (medscape.com)
The cholesterol is then used by the cell, stored, or removed from the body. (medlineplus.gov)
All of these protein changes lead to a reduction of functional apolipoprotein B. As a result, the transportation of dietary fats and cholesterol is decreased or absent. (medlineplus.gov)
Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
High triglycerides are associated with increased risk for CAD in patients with other risk factors, such as low HDL-cholesterol, some patient groups with elevated apolipoprotein B concentrations, and patients with forms of LDL that may be particularly atherogenic. (cdc.gov)
LDL cholesterol , or low-density lipoprotein, carries cholesterol to the cells that need it. (upmc.com)
Familial defective apolipoprotein B-100: High total cholesterol. (upmc.com)
Vallianou et al (2016) evaluated the effect of camphene oil, a constituent of Mastic, on the de novo synthesis of cholesterol and triglycerides from [14C]-acetate in HepG2 cells, along with the statin mevinolin. (masticlife.com)
Camphene inhibited the biosynthesis of cholesterol in a concentration-dependent manner, and a maximal inhibition of 39% was observed at 100 μM while mevinolin nearly abolished cholesterol biosynthesis. (masticlife.com)
The cellular cholesterol content was reduced, after the human hepatic cell line, HepG2, was treated with camphene, to the same level as mevinolin, which is a known HMG-CoA reductase inhibitor. (masticlife.com)
Apolipoprotein B-100 (apoB) is the main carrier of LDL cholesterol to tissues, and high levels have been linked to plaque formation in the blood vessels. (healthnewsyoucanuse.com)
Not only was apoB-100 secretion cut by more than half, but significant decreases also occurred in the synthesis of lipids (fats), including triglycerides and cholesterol esters. (healthnewsyoucanuse.com)
Lipoproteins are composed of a neutral lipid (TAG, cholesteryl esters, or both) core surrounded by a shell of amphipathic apolipoproteins, phospholipid, and unesterified cholesterol. (pharmacy180.com)

Plasma phospholipid levels are very low, while plasma apolipoprotein B, chylomicrons, very-low-density lipoproteins (VLDLs), and low-density lipoproteins (LDLs) are absent. (medscape.com)
The normal-length apolipoprotein B-48 can form chylomicrons normally, but the abnormally short apolipoprotein B-100 produced in the liver is less able to produce lipoproteins. (medlineplus.gov)
Chylomicrons are assembled in intestinal mucosal cells from dietary lipids (primarily TAG). (pharmacy180.com)

Alterations in lipoproteins result either from genetic mutations that yield defective apolipoproteins (primary hyperlipoproteinemia) or from some other underlying systemic disorder, such as diabetes mellitus , hypothyroidism , or nephrotic syndrome (secondary hyperlipoproteinemia). (medscape.com)
Apolipoprotein B-100, which is produced in the liver, is a component of several other types of lipoproteins. (medlineplus.gov)

The objective of this study was to develop an atheroprotective vaccine by targeting a peptide of the LDL protein constituent apolipoprotein B-100 (apoB-100) to the nasal mucosa to induce a protective mucosal immune response. (lu.se)
Methods and Results-A peptide comprising amino acids 3136 to 3155 of apoB-100 (p210) was fused to the B subunit of cholera toxin (CTB), which binds to a ganglioside on mucosal epithelia. (lu.se)
This effect was accompanied by induction of regulatory T cells that markedly suppressed effector T cells rechallenged with apoB-100 and increased numbers of interleukin (IL)-10(+) CD4(+) T cells. (lu.se)
Buy Human Apolipoprotein B-100 (ApoB-100) from Lee Biosolutions. (leebio.com)

Recently, attention has shifted from focusing on lipids toward addressing the immune cell-mediated inflammation contributing to CVD. (frontiersin.org)
The researchers evaluated 42 parameters including 11 genotyping tests, 7 lipids and apolipoproteins, 7 hormones, 6 fatty acid parameters, 3 diabetes markers, and 2 inflammation markers. (thecardiologyadvisor.com)

We first characterized the responses of T cells to P210 using PBMCs from patients with atherosclerotic cardiovascular disease (ASCVD). (jci.org)

Overproduction of apolipoprotein B can result in lipid-induced endoplasmic reticulum stress and insulin resistance in the liver. (wikipedia.org)
The liver secretes the triglyceride-rich VLDL that contains apoproteins B-100, C-II, and E into the circulation. (medscape.com)
[ 3 ] and spur cell hemolytic anemia of severe liver disease. (medscape.com)
Results: IR leads to an accumulation of fatty acids within liver cells, resulting from increased glycolysis and decreased apolipoprotein B-100. (bvsalud.org)
Western blot testing of 1) rat liver, 2) rat RH35, 3) mouse liver and 4) mouse HEPA1-6 cell lysate with APOC3 antibody at 0.5ug/ml. (nsjbio.com)

Intrinsic T cell response to P210 peptide in human PBMCs. (jci.org)
E and F ) AIM + cells in response to P210 or CMV peptide pool. (jci.org)
G - J ) PBMCs were stimulated with P210 peptide for 72 hours, and cells were stained for T effector and memory markers. (jci.org)

Familial LDL receptor deficiency and familial defective apoprotein B-100 are examples of primary defects that can lead to the accumulation of LDL, which corresponds to a type IIa pattern of hyperlipidemia. (medscape.com)
More than 100 mutations in the APOB gene are known to cause familial hypercholesterolemia. (medlineplus.gov)

Low apoB levels may indicate Bassen-Kornzweig syndrome (abetalipoproteinemia), a very rare genetic condition characterized by apolipoprotein B deficiency. (medscape.com)

Apolipoprotein B-48 is produced in the intestine, where it is a building block of a type of lipoprotein called a chylomicron. (medlineplus.gov)
Apolipoprotein B (apoB) is a structural protein that constitutes a major component of the very-low-density lipoprotein (VLDL), the intermediate-density lipoprotein (IDL), and the low-density lipoprotein (LDL). (medscape.com)

Loizou et al (2009), investigated the effect of Chios Mastic neutral extract and tirucallol on the expression of adhesion molecules (VCAM-1 and ICAM-1) and the attachment of monocytes (U937 cells) in TNF-a stimulated Human Aortic Endothelial Cells (HAEC). (masticlife.com)

Conclusions: Taken together, these findings suggest that cigarette smoking promotes arterial thrombosis and modulates the size and composition of neointimal lesions after arterial injury in apolipoprotein E-deficient mice. (pmiscience.com)

They are released from the cells into the lymphatic system and travel to the blood, where they receive apo C-II and apo E from HDLs. (pharmacy180.com)

Recently, in the light of many efforts in the field of regenerative medicine, mice have gained increasing interest as a suitable source of adipose tissue for the extraction of mesenchymal stem cells, which can be used in the preclinical investigations in order to aid in the treatment of many human diseases. (bvsalud.org)
Methods: Apolipoprotein E-deficient mice were exposed to filtered air (sham) or to cigarette mainstream smoke at a total particulate matter (TPM) concentration of 600 µg/l for 1, 2, 3, or 4 h, for 5 days/week. (pmiscience.com)
Aging influence on pulmonary and systemic inflammation and neural metabolomics arising from pulmonary multi-walled carbon nanotube exposure in apolipoprotein E-deficient and C57BL/6 female mice. (cdc.gov)

Additional analysis of smooth muscle cells in vitro suggested that 10 µg TPM/ml increased cell proliferation without affecting viability or apoptosis, whereas higher concentrations (100 and 500 µg TPM/ml) appeared to be cytotoxic. (pmiscience.com)
This study was designed to determine the effects of the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 ( PVT1 ) on vascular smooth muscle cell (VSMC) apoptosis and extracellular matrix (ECM) disruption in a murine abdominal aortic aneurysm (AAA) model. (molcells.org)
Of note, the effects of Ang II in facilitating cell apoptosis, increasing matrix metalloproteinase (MMP)-2 and MMP-9, reducing tissue inhibitor of MMP (TIMP)-1, and promoting switching from the contractile to synthetic phenotype in cultured VSMCs were enhanced by overexpression of PVT1 but attenuated by knockdown of PVT1 . (molcells.org)

Scientists at Tokyo's Graduate School of Agriculture have shown that isothiocyanates can block the growth of melanoma skin cancer cells, according to findings published in 1999 in the journal "Nutrition and Cancer. (healthnewsyoucanuse.com)

Cardiovascular immunotherapy has therefore become a recent focus for treatment, with the objective to develop approaches that can suppress excessive inflammatory responses by modulating specific immune cell populations. (frontiersin.org)
Apolipoprotein B (apoB) levels are used to evaluate the risk for cardiovascular disease. (medscape.com)
Some evidence has shown that the capacity of the apoB/apoA-I ratio in assessing cardiovascular risk is strong and may be better than the use of apolipoprotein B alone. (medscape.com)

A benefit of such immunomodulatory strategies is that low dosage stimulation of key immune cell populations, like antigen presenting cells, can subsequently propagate strong proliferation and therapeutic responses from effector cells. (frontiersin.org)
K ) Gating scheme for T effector and memory cell analysis. (jci.org)

The natural cytotoxicity receptor NKp44 (NCR2, CD336) is expressed on the majority of porcine NK cells ex vivo without stimulation. (usda.gov)

Novel small molecule therapeutics for sickle cell disease: nitric oxide, carbon monoxide, nitrite, and apolipoprotein A-I. (johnshopkins.edu)
A hemolysis-linked subphenotype of sickle cell disease (SCD), characterized by pulmonary hypertension, stroke, priapism and leg ulcers, is associated with decreased nitric oxide bioavailability and vasculopathy. (johnshopkins.edu)
Vasculopathy appears to have a multifactorial etiology, including mechanisms primarily that involve deficient nitric oxide (NO) signaling, but also involving altered function of NO synthase related to substrate availability and cooperating factors such as apolipoproteins. (johnshopkins.edu)

P210 provoked T cell activation and memory response in PBMCs of patients with ASCVD. (jci.org)
Dendritic cell uptake of P210-PAM and its costaining with MHC-I molecules supported its use as a vaccine formulation. (jci.org)

Xanthomas can develop in the setting of altered systemic lipid metabolism or as a result of local cell dysfunction. (medscape.com)
Characterized by an influx of white blood cells, redness, heat, swelling, pain, and dysfunction of the organs involved, inflammation has different names when it appears in different parts of the body. (drsircus.com)

I3C was shown to suppress the growth of prostate cancer cells in a dose-dependent manner by blocking several important steps in cell cycling and also to inhibit the production of prostate specific antigen (PSA), a protein produced by the prostate whose rising levels may indicate prostate cancer. (healthnewsyoucanuse.com)

In an immunochemical reaction, Apolipoprotein B in the human serum sample form immune complexes with specific antibodies. (cdc.gov)
Serum and red blood cell samples were subsequently analyzed and results compared with analysis results of serum collected after venipuncture. (thecardiologyadvisor.com)

scDiffCom is an R package, relying on approximately 5,000 curated ligand-receptor interactions, that performs differential intercellular communication analysis between two conditions from single-cell transcriptomics data. (nature.com)

The protein is constitutively secreted by a number of cell types including epithelial and neuronal cells and is a major protein in physiological fluids including plasma, milk, urine, cerebrospinal fluid and semen. (biovendor.com)

Research on indole-3-carbinol shows this compound helps deactivate a potent estrogen metabolite (4-hydroxyestrone) that promotes tumor growth, especially in estrogen-sensitive breast cells, while at the same time increasing the level of 2-hydroxyestrone, a form of estrogen that can be cancer-protective. (healthnewsyoucanuse.com)

Morphometric and immunohistochemical analysis of neointimal lesions demonstrated that mainstream smoke exposure increased the amount of α-actin-positive smooth muscle cells (p (pmiscience.com)

Indeed, the exosomes derived from mesenchymal stem cells can represent the same therapeutic potential as parent cells with fewer side effects. (bvsalud.org)
Over the past years, stem cell technology was heralded as a significant breakthrough of the century in scrutinizing the intricacies of human body biology and discovering different therapeutic approaches. (bvsalud.org)
Adipose tissue, especially brown type, is considered an attractive cell source for various therapeutic purposes, such as restoring damaged tissue or fighting against diseases such as obesity. (bvsalud.org)

Indole-3-carbinol has been shown to suppress not only breast tumor cell growth, but also cancer cell metastasis (the movement of cancerous cells to other parts of the body). (healthnewsyoucanuse.com)

We have previously demonstrated that intravenous injections of anti-inflammatory nanocarriers provided atheroprotection that was mediated by regulatory T cells (Tregs) upregulated in lymphoid organs and atherosclerotic lesions. (frontiersin.org)

Strategies targeting the hemeoxygenase-carbon monoxide pathway, the arginine-NO synthase-cGMP-phosphodiesterase 5 pathway, the nitrate-nitrite-NO pathway, and the apolipoprotein A-I pathways will be reviewed. (johnshopkins.edu)
Cell culture and animal model work have demonstrated that modulating gene expression through RXR-mediated pathways may mitigate or reverse cognitive decline. (elsevierpure.com)
Herein, we describe experiments in which we analyze a series of novel and previously reported rexinoids for their ability to modulate specific gene pathways implicated in neurodegenerative disorders employing a U87 cell culture model. (elsevierpure.com)

Most APOB gene mutations that cause FHBL lead to the production of apolipoprotein B that is abnormally short. (medlineplus.gov)
The severity of the condition largely depends on the length of the abnormal apolipoprotein B. Some mutations in the APOB gene lead to the production of a protein that is shorter than apolipoprotein B-100, but longer than apolipoprotein B-48. (medlineplus.gov)
Other mutations result in a protein that is shorter than both apolipoprotein B-48 and apolipoprotein B-100. (medlineplus.gov)
PMID:18786442 mutations and the risk of esophageal squamous cell carcinoma. (who.int)

Psoriasis has wide clinical spectra that range from epidermal (scaly) to vascular (thickened) erythematous involvement associated with epidermal hyperproliferation, abnormal keratinocyte differentiation, angiogenesis with blood vessel dilation, and the presence of inflammatory cells in the superficial dermis and epidermis. (hindawi.com)

Trastorno familiar que se caracteriza por incremento de la concentración del colesterol transportado por las lipoproteínas de baja densidad (LDL) y por déficit de un receptor en la superficie celular que regula la degradación de las LDL y la síntesis del colesterol. (bvsalud.org)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)

These infiltrating cells secrete various inflammatory cytokines, such as tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. (molcells.org)

Cur- squamous cell carcinoma, Australia. (who.int)
risk of esophageal squamous cell carcinoma. (who.int)
Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch squamous cell carcinoma in a high-risk region in Iran. (who.int)

Each mutation that causes this condition changes a single protein building block (amino acid) in a critical region of apolipoprotein B-100. (medlineplus.gov)
Apolipoproteins were separated by SDS-polyacrylamide gel electrophoresis and identified by silver nitrate staining, Western blotting, and N-terminal amino acid sequencing. (elsevierpure.com)

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