Cells antigens human platelet. Medical search. Frequent questions

He received 7.16 × 10 8 nucleated bone marrow cells/kg body weight from a 9/10 human leukocyte antigen-matched unrelated donor. (cdc.gov)
Antibodies directed against white blood cell (WBC) human leukocyte antigen (HLA) in otherwise compatible donor blood are one possible cause. (merckmanuals.com)
1. HLA is the acronym for human leukocyte antigen, a genetic maker found on cells of the body that determine white blood cell types. (discovernikkei.org)
Moreover, alloantibodies against human leukocyte antigen class I (HLA-I) and to a lesser extent to human platelet antigen (HPA) cause alloimmune platelet transfusion refractoriness (allo-PTR) in 5-15% of patients receiving platelet transfusion. (biomedcentral.com)
It has been suggested that cytokine acc leukoreduction prevents transmission of cyc cumulation in plasma of platelet concenc tomegalovirus and decreases alloimmunizac trates (PC) during storage may contribute tion to human leukocyte antigen (HLA), it to development of nonchaemolytic febrile does not prevent allergic reactions. (who.int)

CD69 stimulation by anti-Leu-23 monoclonal antibodies induced platelet aggregation in a dose-dependent fashion. (nih.gov)
TotalSeq™-D antibodies are compatible with Mission Bio's Tapestri Single-Cell Sequencing Platform for simultaneous detection of DNA and Protein. (biolegend.com)
AHTR usually results from recipient plasma antibodies to donor RBC antigens. (merckmanuals.com)
Antibodies against blood group antigens other than ABO can also cause AHTR. (merckmanuals.com)
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
This extensive immune cross-reactivity between SARS-CoV-2 antibodies and different antigen groups may play a role in the multi-system disease process of COVID-19, influence the severity of the disease, precipitate the onset of autoimmunity in susceptible subgroups, and potentially exacerbate autoimmunity in subjects that have pre-existing autoimmune diseases. (frontiersin.org)
Very recently, human monoclonal antibodies were approved for use on patients with COVID-19. (frontiersin.org)
The human monoclonal antibodies used in this study are almost identical with these approved antibodies. (frontiersin.org)
In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
Associations between blood type and disease have been studied since the early 1900s when researchers determined that antibodies and antigens are inherited. (rti.org)
Immunotherapy with monoclonal antibodies may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (bcan.org)
This list concerns blood type distribution between countries and regions.Blood type (also called a blood group) is a classification of blood, based on the presence and absence of antibodies and inherited antigenic substances on the surface of red blood cells (RBCs). (feministlawprofessors.com)
All the monoclonal antibodies that belong to the CD45 cluster react with this part of the antigen and are able to recognize all CD45 isoforms. (beckman.com)
1. Chen S, Cooper N, Müller M, Bein G, Sachs UJ (2020) Piperacillin-dependent anti-platelet antibodies are a relevant, easy to confirm differential diagnosis in patients with rapid-onset thrombocytopenia. (uni-giessen.de)
12. Sachs UJ, Wienzek-Lischka S, Duong Y, Qiu D, Hinrichs W, Cooper N, Santoso S, Bayat B, Bein G (2020) Maternal antibodies against paternal class I human leukocyte antigens are not associated with foetal and neonatal alloimmune thrombocytopenia. (uni-giessen.de)
The characteristics of this response would include production of neutralizing antibodies, generation of a T-cell response, and avoidance of immune-enhanced disease4. (who.int)

Further transfusion should be delayed until the cause of the reaction is known, unless the need is urgent, in which case type O Rh-negative red blood cells (RBCs) should be used. (merckmanuals.com)
The HLA system is used to assess tissue compatibility for organ transplantation and platelet transfusion. (discovernikkei.org)
In addition, blood-borne infections and alloimmune platelet transfusion refractoriness are not completely resolved. (biomedcentral.com)
Based on these developments, we initiated the first-in-human clinical trial of iPSC-derived platelets to a patient with alloimmune platelet transfusion refractoriness (allo-PTR) using an autologous product. (biomedcentral.com)
Transfusion-dependent beta-thalassemia, the most severe form of the condition, generally requires life-long red blood cell transfusions as the standard course of treatment. (genengnews.com)
Effectiveness was established based on achievement of transfusion independence, which is attained when the patient maintains a pre-determined level of hemoglobin without needing any red blood cell transfusions for at least 12 months. (genengnews.com)
Uhl L. Pretransfusion testing for red blood cell transfusion. (feministlawprofessors.com)
The occurrence of the acquired immunodeficiency syndrome (AIDS) in intravenous (IV) drug users, blood transfusion recipients, and persons with hemophilia indicates that parenteral transmission of human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) occurs via infectious blood or blood products (1). (cdc.gov)
As part of his job, he processed platelets pooled from individual donors for transfusion. (cdc.gov)

The response of a B cell to antigen is dependent on the surface expression of a clonotypic B-cell receptor complex (BCR) consisting of membrane-bound Ig and disulfide-linked heterodimers of Ig alpha/beta. (nih.gov)
Therefore, we developed a novel system in which we could form and then aggregate dimers, representative of partial receptor complexes, which contained either Ig alpha alone, Ig beta alone, or the two chains together and then examine their ability to induce apoptosis in the immature B-cell line, WEHI-231. (nih.gov)
These findings may provide insight into the mechanisms by which the BCR, and other such multimeric receptor complexes, initiate both apoptotic and proliferative responses to antigen. (nih.gov)
CD140b is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. (biolegend.com)
The 18A2 monclonal antibody recognizes human CD140b also known as the platelet-derived growth factor receptor, beta polypeptide, PDGFR1, and PDGFRß. (biolegend.com)
Extracellular matrix receptor and platelet antigens on osteoclasts and foreign body giant cells. (ox.ac.uk)
CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. (biolegend.com)
CD42b, also known as GP1Ba (GP1B alpha, Glycoprotein 1Ba) is a single pass transmembrane glycoprotein that functions as the key ligand binding subunit of the GP1B platelet surface receptor. (peprotech.com)
The association of CD42b/GP1Ba with GP1Bb (covalently) and platelet glycoproteins IX and V (non‐covalently) forms the von Willebrand factor receptor. (peprotech.com)
The binding of von Willebrand factor (VWF) to its platelet receptor initiates the primary mechanism for the adhesion of platelets to a site of vascular injury and subsequent platelet activation. (peprotech.com)
We undertook this study to investigate receptor (IL-2R) accumulation is related to whether the cytokine accumulation in PCs the leukocyte content of the platelet comc obtained from single apheresis donors was ponent and can be reduced by prestorage beyond the acceptable limits of WBC conc leukocyte depletion [ 3 ]. (who.int)
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. (exbio.cz)
Cell surface receptor for NECTIN2. (cusabio.com)
GM1CD9 triggers platelet activation resulted in platelet aggregation, but it is blocked by anti-Fc receptor CD32. (techblessing.com)

CD31 antigen. (invivogen.com)
CD31/PECAM-1 impacts engraftment, growth and spread of mantle cell lymphoma cells and positively correlates with extramedullary involvement. (invivogen.com)
Mouse monoclonal to CD31.COB31 monoclonal reacts with human CD31, a 130-140kD glycoprotein, which is also known as platelet endothelial cell adhesion molecule-1 (PECAM-1). (bioinf.org)
The CD31 antigen is expressed on platelets and endothelial cells at high levels, as well as on T-lymphocyte subsets, monocytes, and granulocytes. (bioinf.org)

Platelet and endothelial cell adhesion molecule 1. (invivogen.com)
The antigenic phenotype of OCs and foreign body giant cells (FBGCs) was investigated for the presence of several integrin molecules and other largely platelet-associated antigens involved in cell adhesion reactions. (ox.ac.uk)
When Lmo1059 was deleted, the adhesion and invasion of L. monocytogenes were reduced while the cell-to-cell spread was increased, suggesting an intricate role of Lmo1059 during bacterial infection. (bvsalud.org)
The VWF gene encodes von Willebrand factor (VWF), a large multimeric glycoprotein that plays a central role in the blood coagulation system, serving both as a major mediator of plateletvessel wall interaction and platelet adhesion, and as a carrier for coagulation factor VIII. (innov-research.com)
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. (cusabio.com)
CD9 antigen modulates cell adhesion, migration and platelet activation. (techblessing.com)

It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. (biolegend.com)
It is absent from erythrocytes and platelets. (beckman.com)
The mouse monoclonal antibody HI30 recognizes an extracellular epitope on all isoforms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets. (exbio.cz)

They showed that opposing gradients of bone morphogenetic protein (BMP) and Nodal, two transforming growth factor family members that act as morphogens, are sufficient to induce molecular and cellular mechanisms required to organize, in vivo or in vitro, uncommitted cells of the zebrafish blastula animal pole into a well-developed embryo. (wikipedia.org)
TotalSeq™-D reagents are designed to profile protein expression at single cell level. (biolegend.com)
The CD9 antigen is also known as p24, tetraspanin-29 (Tspan-29), motility-related protein-1 (MRP-1), and leucocyte antigen MIC3. (bdbiosciences.com)
Recombinant Human sCD42b/GP1Ba is a 54.6 kDa protein containing 496 amino acid residues that correspond to the extracellular portion of CD42b/GP1Ba, plus a C‐terminal His‐Tag. (peprotech.com)
Interestingly, three soluble factors released from imMKCLs in the turbulent flow condition, macrophage migration inhibitory factor (MIF), insulin growth factor binding protein 2 (IGFBP2), and nardilysin (NRDC), enhanced platelet production. (biomedcentral.com)
This Human CD226 ELISA Kit was designed for the quantitative measurement of Human CD226 protein in serum, plasma, tissue homogenates. (cusabio.com)
The cell surface protein Fas (CD95) and its ligand play a pivotal role in regulating lymphocyte apoptosis, and defective expression of either Fas or Fas ligand results in marked overaccumulation of mature lymphocytes and autoimmune disease in mice. (medscape.com)
Shortly after SARS-CoV emerged at the turn of the 21st century, the spike (S) protein (particularly in its native conformation) was identified as the immunodominant antigen of the virus3. (who.int)

Graft-versus-host disease (GvHD) prophylaxis consisted of a short course of methotrexate and cyclosporin A. Neutrophil and platelet engraftment occurred on days 22 and 65 after surgery, respectively. (cdc.gov)
BACKGROUND AND OBJECTIVES: Polymorphic molecules expressed on the surface of certain blood cells are traditionally categorized as blood groups and human platelet or neutrophil antigens. (lu.se)

Cytokines released from WBCs during storage, particularly in platelet concentrates, are another possible cause. (merckmanuals.com)
The study found significant cytokine accumulation during 5 days of storage time in leukocyte contaminated platelet concentrates, suggesting that the platelet storage time has an effect on IL-2R levels. (who.int)
WBC) and proinflammatory cytokines in All PCs were obtained from healthy volc the supernatant of platelet concentrates unteer donors by apheresis (CSc3000 Plus, [ 4,5 ]. (who.int)

Osteoclasts (OCs) and other cells of the mononuclear phagocyte system possess receptors for adhesive proteins present in the extracellular matrix. (ox.ac.uk)
Natural killer cells and cytotoxic T cells express both TIGIT and DNAM-1 receptors, and in certain cases their effector functions are dictated by TIGIT or DNAM-1 signaling. (cusabio.com)

CD69, a surface dimer so far considered an early activation antigen restricted to lymphocytes, was found constitutively expressed on human platelets. (nih.gov)
These results suggest that CD69 may function as an activating molecule on platelets, as on lymphocytes, and point toward a more general role of this surface dimer in signal transduction. (nih.gov)
The non-restricted CD45 epitope is present on the surface of all human leucocytes, lymphocytes, eosinophils monocytes, basophils and neutrophils by order of decreasing level of expression. (beckman.com)
Intro Cutaneous T-cell lymphomas (CTCLs) are uncommon malignancies of skin-homing T lymphocytes. (techblessing.com)
Programmed cell death (apoptosis) of activated lymphocytes is critical to immune homeostasis. (medscape.com)

The non-restricted CD45, Leucocyte Common Antigen (LCA) consists of an extracellular sequence, proximal to the membrane, which is common to all CD45 isoforms. (beckman.com)
VWF released from endothelial cell Weibel-Palade bodies bound particularly avidly to the extracellular matrix. (innov-research.com)
Produced by a variety of cell types, extracellular vesicles (EVs) are able to transfer lipids, nucleic acids and proteins to recipient cells. (nature.com)

The CD9 antibody recognizes a 24-kilodalton (kDa) cell surface glycoprotein belonging to the tetraspanin family. (bdbiosciences.com)
CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. (biolegend.com)
CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. (exbio.cz)

Leucocyte Typing III: White Cell Differentiation Antigens. (bdbiosciences.com)
Leukocyte differentiation antigens often represent important markers for the diagnosis, classification, prognosis, and therapeutic targeting of myeloid leukemia. (biomedcentral.com)

CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. (biolegend.com)
CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. (biolegend.com)
Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. (exbio.cz)
Cosenza-Nashat MA, Kim MO, Zhao ML, Suh HS, Lee SC: CD45 isoform expression in microglia and inflammatory cells in HIV-1 encephalitis. (exbio.cz)
Bijian K, Zhang L, Shen SH: Collagen-mediated survival signaling is modulated by CD45 in Jurkat T cells. (exbio.cz)

Differentiated airway epithelial cells can revert into stable and functional stem cells in vivo. (wikipedia.org)
Holmer C, Essmann M, Ault K, Larsen B . Adherence and blocking of Candida Albicans to cultured vaginal epithelial cells: Treatments to decrease adherence. (dmu.edu)
It also expressed on eosinophils, basophils, endothelial and epithelial cells. (techblessing.com)

The cyclic nature of the capillary bed in the corpus luteum offers a unique experimental model to examine the life cycle of endothelial cells, involving discrete physiologically regulated steps of angiogenesis, blood vessel maturation and blood vessel regression. (biomedcentral.com)
On the other end of the spectrum, the microvascular endothelial cells are the first cells to undergo apoptosis at the onset of corpus luteum regression. (biomedcentral.com)
Important insights on the morphology and function of luteal endothelial cells have been gained from a combination of in vitro and in vivo studies on endothelial cells. (biomedcentral.com)
Endothelial cells communicate with cells comprising the functional unit of the corpus luteum, i.e ., other vascular cells, steroidogenic cells, and immune cells. (biomedcentral.com)
This review is designed to provide an overview of the types of endothelial cells present in the corpus luteum and their involvement in corpus luteum development and regression. (biomedcentral.com)
Available evidence indicates that microvascular endothelial cells of the corpus luteum are not alike, and may differ during the process of angiogenesis and angioregression. (biomedcentral.com)
The contributions of vasoactive peptides generated by the luteal endothelin-1 and the renin-angiotensin systems are discussed in context with the function of endothelial cells during corpus luteum formation and regression. (biomedcentral.com)
The review highlights areas for future investigation of ovarian microvascular endothelial cells. (biomedcentral.com)
The potential clinical applications of research directed on corpus luteum endothelial cells are intriguing considering reproductive processes in which vascular dysfunctions may play a role such as ovarian failure, polycystic ovary syndrome (PCOS), and ovarian hyperstimulation syndrome (OHSS). (biomedcentral.com)
Evidence of proliferating endothelial cells was determined by the presence of Ki-67 antigen-positive cells, bromodeoxyuridine-positive cells, or [ 3 H] thymidine-positive cells. (biomedcentral.com)
Epithelioid angiosarcoma is a rare malignant neoplasm found in vascular endothelial cells. (bvsalud.org)
The histologic hallmark of AE is represented by the presence of sheets and groups of atypical endothelial cells with prominent epithelioid morphologies. (bvsalud.org)

Autoantibodies targeting different antigenic determinants on red blood cells (RBCs) and platelets are assumed to cause isolated episodes of hemolytic anemia and thrombocytopenia, respectively. (medscape.com)
Non-cross-reacting autoantibodies are directed against antigens specific to RBCs, platelets, or neutrophils. (medscape.com)

Since human induced pluripotent stem cell (iPSC)-platelet products can be supplied independently from the donor, it is expected to complement current platelet products. (biomedcentral.com)
1. The only exception to this rule is when no blood samples are available before the donor is given red blood cell (RBC) products. (feministlawprofessors.com)

CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis. (bdbiosciences.com)
Knockdown of NRAS by siRNA induced apoptosis in mutant Hut78 cells however, not in CTCL cell lines missing RAS mutations. (techblessing.com)
Furthermore, we discovered that MEK inhibitors specifically induce apoptosis in Hut78 cells. (techblessing.com)

Platelets are released from megakaryocytes (MKs) in the bone marrow and circulate as anucleate blood cells with a diameter of about 2-4 μm. (biomedcentral.com)
Each dose of Zynteglo is a customized treatment created using the patient's own bone marrow stem cells that are genetically modified to produce functional beta-globin. (genengnews.com)
It is lost during maturation of erythroid cells in the bone marrow. (beckman.com)
Giving colony-stimulating factors, such as filgrastim or pegfilgrastim, and certain chemotherapy drugs, helps stem cells move from the bone marrow to the blood so they can be collected and stored. (cincinnatichildrens.org)
Chemotherapy is then given to prepare the bone marrow for the stem cell transplant. (cincinnatichildrens.org)
Herein, we report a potential leukocyte differentiation antigen gene VSTM1 ( V-set and transmembrane domain-containing 1 ) that was downregulated in bone marrow cells from leukemia patients and exhibited a higher degree of promoter methylation. (biomedcentral.com)
To determine whether it plays a role in leukemogenesis, we characterized its expression pattern and function in bone marrow cells from AML/CML patients and myeloid leukemia cell lines. (biomedcentral.com)
We measured VSTM1 expression in leukemia cell lines and bone marrow biopsies from leukemia patients using qRT-PCR. (biomedcentral.com)

Nevertheless, in tumor cells, mutated TCS ERK 11e (VX-11e) (oncogenic) RAS preferentially promotes success and proliferation. (techblessing.com)
Drugs used in chemotherapy, such as paclitaxel, ifosfamide, cisplatin, carboplatin, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (cincinnatichildrens.org)

Effective June 22, 2021, donors who have had a splenectomy (spleen removal) will not be eligible to donate platelets on our apheresis instruments (Trima Accel) due to a software change. (childrensnational.org)

Thus, our results can establish the potential risk for autoimmunity and multi-system disorders with COVID-19 that may come from cross-reactivity between our own human tissues and this dreaded virus, and thus ensure that the badly-needed vaccines and treatments being developed for it are truly safe to use against this disease. (frontiersin.org)

To maximize performance, it is strongly recommended that the reagent be titrated for each application, and that you centrifuge the antibody dilution before adding to the cells at 14,000xg at 2 - 8°C for 10 minutes. (biolegend.com)
The CD9 antibody, clone M-L13, is derived from the hybridization of mouse myeloma cells with spleen cells isolated from mice immunized with common acute lymphoblastic leukemia (cALL) cells. (bdbiosciences.com)
Anti-CD9 monoclonal antibody activates p72syk in human platelets. (bdbiosciences.com)
Multiparameter flow cytometric analysis using BD OptiBuild™ BV786 Mouse Anti-Human CD81 (TAPA-1) antibody (Cat. (bdbiosciences.com)

These patients with allo-PTR require HLA-I/HPA-matched platelet transfusions, presumed to be more than 20,000 bags of platelets per year in Japan, which increases the risk of supply shortages due to limited donors or even complete unavailability in the case of rare types and emergencies [ 7 ]. (biomedcentral.com)
During the experimental culture of CD34+ cells from random blood donors, we observed that one individual lacked CD36. (lu.se)
It is not known whether any of the individual platelet donors or the patient with leukemia had HTLV-III infection. (cdc.gov)

Introduction tions of T-cell derived IL-2R are increased in mixed lymphocyte cultures. (who.int)

We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

CD36 is widely considered a platelet antigen (Nak a ) and anti-CD36 can cause foetal/neonatal alloimmune thrombocytopenia (FNAIT) in CD36-negative pregnant women. (lu.se)

We do a processing out of the whole blood units where we prepare red blood cells, platelets, plasma and cryoprecipitate. (dailymirror.lk)
However, you can donate whole blood (red blood cells and plasma) even if you have recently taken aspirin. (childrensnational.org)
Beta-thalassemia is a type of inherited blood disorder that causes a reduction of normal hemoglobin and red blood cells in the blood, through mutations in the beta-globin subunit, leading to insufficient delivery of oxygen in the body. (genengnews.com)
The reduced levels of red blood cells can lead to a number of health issues including dizziness, weakness, fatigue, bone abnormalities, and more serious complications. (genengnews.com)
There are four major blood groups determined by the presence or absence of two antigens - A and B - on the surface of red blood cells. (feministlawprofessors.com)
In an emergency, type O negative red blood cells may be given to anyone - especially if the situation is life-threatening or the matching blood type is in short supply. (feministlawprofessors.com)
13.6 million units of whole blood and red blood cells are collected in the U.S. in a year. (feministlawprofessors.com)
Landsteiner observed two distinct chemical molecules present on the surface of the red blood cells. (feministlawprofessors.com)
Red blood cells represent 40%-45% of your blood volume. (feministlawprofessors.com)
Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 10 6 cells in a suspension. (exbio.cz)
Genetic and flow cytometric analyses on peripheral blood cells were performed. (lu.se)
Blood cells, molecules & diseases 2017 Jun 65 60-65. (cdc.gov)
The cells are usually large and polygonal, containing abundant eosinophilic cytoplasm, a large nucleus with open chromatin, a prominent eosinophilic nucleolus, and an occasional intracellular lumina containing red blood cells 1,4-7 . (bvsalud.org)

After injury, mature terminally differentiated kidney cells dedifferentiate into more primordial versions of themselves and then differentiate into the cell types needing replacement in the damaged tissue Macrophages can self-renew by local proliferation of mature differentiated cells. (wikipedia.org)
Binding of B-chain containing PDGF molecules can stimulate cell proliferation. (biolegend.com)
Processes involved in atherosclerosis include coagulation, inflammation, lipid metabolism, intimal injury, and smooth muscle cell proliferation (see the image below). (medscape.com)
Collectively, these studies demonstrate that the rate of endothelial cell proliferation is highest during corpus luteum formation, then decreases and remains low during the mid-luteal phase and structural regression of the corpus luteum. (biomedcentral.com)
The regulation of endothelial cell proliferation in the corpus luteum of pregnancy is less clear. (biomedcentral.com)

Human immunology 81 (7): 366-371. (uni-giessen.de)

Biochemical analysis revealed that platelet CD69 appears on sodium dodecyl sulfate-polyacrylamide gel electrophoresis as a broad 55-65-kD band, in which three 55-, 60-, and 65-kD components were detectable when nonreduced, and as two 28- and 32-kD bands when reduced, corresponding to the two disulfide-linked chains of the dimer. (nih.gov)
Further research to identify differences in the biochemical composition of blood group antigens, and the relationship to risks for disease, can be important for the identification of targets for the development of nutritional intervention strategies, or the identification of druggable targets. (rti.org)
Biochemical assays indicated that SVEVs are functionally active, showing high metalloproteinase and fibrinogenolytic activity besides being cytotoxic against HUVEC cells. (nature.com)

CD81 has a very broad cellular distribution, being expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin. (bdbiosciences.com)

The RAS-RAF-MEK-ERK signaling pathway regulates cell reactions to environmental stimuli and takes on a crucial part in many malignancies.6 Thus, RAF and MEK are attractive therapeutic focuses on.7,8 RAS is a little guanine-nucleotide binding proteins that is mounted on the inner part from the plasma membrane. (techblessing.com)

The blood type is defined by oligosaccharide structures, which are specific to the antigens, thus, blood group antigens are secondary gene products, while the primary gene products are various glycosyltransferase enzymes that attach the sugar molecules to the oligosaccharide chain. (rti.org)

One example is the transformation of iris cells to lens cells in the process of maturation and transformation of retinal pigment epithelium cells into the neural retina during regeneration in adult newt eyes. (wikipedia.org)
The fact that transdetermination (change of the path of differentiation) often occurs for a group of cells rather than single cells shows that it is induced rather than part of maturation. (wikipedia.org)
The expression level of its predominant encoded product, VSTM1-v1, was positively correlated with myeloid cell maturation state. (biomedcentral.com)
A combination of CD34/CD117/CD13/CD16 staining showed that VSTM1-v1 expression in myeloid cells was positively correlated with cell maturation state. (biomedcentral.com)

Polymorphism of the human platelet antigen-5 system is a risk factor for occlusive vascular complications in patients with sickle cell anemia. (cdc.gov)
MTHFR polymorphic variant C677T is associated to vascular complications in sickle-cell disease. (cdc.gov)
T polymorphism and vascular complications in sickle cell disease: A meta-analysis. (cdc.gov)

Platelet products are used in treatments for thrombocytopenia caused by hematopoietic diseases, chemotherapy, massive hemorrhages, extracorporeal circulation, and others. (biomedcentral.com)

They form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency and can differentiate into endodermal, ectodermal and mesodermal cells both in vitro and in vivo. (wikipedia.org)
In this review, we detail current research in this field and our study about the ex vivo production of iPSC-derived platelets. (biomedcentral.com)
BRAFV600E mutation however, not in wild-type BRAF or tumors having a KRAS mutation.12,14,15 Further, dealing with wild-type BRAF tumors with BRAFV600E specific inhibitors induced tumor growth in vitro and in vivo.14 Thus, MEK inhibitors may be appealing in wild-type BRAF cells. (techblessing.com)
Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)

To assess the presence of antigen-specific immune responses to a broad panel of candidate tumor antigens. (bcan.org)
This human VWF-A2 ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. (innov-research.com)

2021. Cell. (biolegend.com)

Les numérations plaquettaire et leucocytaire ainsi que la concentration en cytokines (IL-2R, IL-8 et TNF-) ont été me- surées. (who.int)
The ability of two cytokines, tumor necrosis factor alpha and interferon gamma, are evaluated as paracrine mediators of endothelial cell function during angioregression. (biomedcentral.com)

The FDA has approved Bluebird Bio's Zynteglo as the first cell-based gene therapy for the treatment of adult and pediatric patients with beta-thalassemia who require regular red blood cell transfusions. (genengnews.com)
The role of rs1984112_G at CD36 gene in increasing reticulocyte level among sickle cell disease patients. (cdc.gov)

The data suggest that cell-cell and cell-matrix interactions involving adhesive proteins may be important in OC and FBGC function. (ox.ac.uk)
We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. (digibookee.com)

In addition, CD69 stimulation in platelets induced production of thromboxane B2 and PGE2, suggesting activation of arachidonic acid metabolism by cycloxygenase. (nih.gov)
As observed for CD69-mediated T cell activation, platelet activation through CD69 requires molecular crosslinking. (nih.gov)

CD140b is widely expressed on a variety of mesenchymal-derived cells and is preferentially expressed on some tumors such as medulloblastoma. (biolegend.com)
Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)

Determined by its ability to bind recombinant human von Willebrand Factor-A2 in a functional ELISA. (peprotech.com)
This Human Von Willebrand Antigen 2 ELISA Kit from Innovative Research is intended for quantitative detection of human VWF-A2 in cell culture supernates, serum and plasma (heparin, EDTA). (innov-research.com)

I. To assess for tumor-based biomarkers of response and resistance to this combination therapy using single-cell RNA sequencing (scRNA-seq) and high-dimensional flow cytometry. (bcan.org)
MATERIALS AND METHODS: Surface markers were monitored by flow cytometry on developing cells during the erythroid culture of CD34+ cells. (lu.se)

It can be transfused in its original form, or used to help multiple people when separated into its specific components of red cells, plasma and platelets.Learn more about whole blood donations. (feministlawprofessors.com)
Tembhare PR, Subramanian PG, Sehgal K, Yajamanam B, Kumar A, Gadge V, Inamdar N, Gujral S: Immunophenotypic profile of plasma cell leukemia: a retrospective study in a reference cancer center in India and review of literature. (exbio.cz)
8. Phuangtham R, Santoso S, Leelayuwat C, Komvilaisak P, Ding H, Romphruk AV (2020) Frequency of CD36 deficiency in Thais analyzed by quantification of CD36 on cell surfaces and in plasma. (uni-giessen.de)

decreases in helper T cells and increases in suppressor T cells were noted in these patients. (medscape.com)

One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
In this combined immunodeficiency (SCID) cancer is low in these species (as it chapter, some aspects of this issue mice, in which the human target is in humans), which renders cancer are discussed. (who.int)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

Anatomy26

Organisms7

Diseases7

Chemicals and Drugs163

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes28

Disciplines and Occupations1

Information Science3

Health Care1

Leukocyte antigen5

Antibodies18

Transfusion9

Receptor14

CD314

Adhesion6

Erythrocytes and platelets3

Protein8

Neutrophil2

Concentrates3

Receptors2

Lymphocytes5

Extracellular3

Glycoprotein3

Differentiation Antigens2

CD455

Epithelial cells3

Endothelial cells12

RBCs2

Donor2

Apoptosis3

Bone marrow8

Tumor Cells2

Apheresis1

Reactivity1

Antibody4

Donors3

Lymphocyte1

Tissues2

Neonatal alloimmune throm1

Blood cells13

Proliferation5

Immunology1

Biochemical3

CD811

Reactions1

Molecules1

Maturation4

Vascular3

Thrombocytopenia1

Vivo5

Immune2

20211

Cytokines2

Gene2

Proteins3

Activation2

Widely2

Willebrand2

Flow cytometry2

Plasma3

Decreases1

Mice3