Cells antigens cd7. Medical search. Frequent questions

Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. (nature.com)
Classical " CARs consist of an extracellular binding domain mostly derived from a monoclonal antibody fragment (single-chain variable fragment-scFv), which is linked to intracellular binding domains of the T-cell receptor complex. (nature.com)
In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor. (exbio.cz)
Nishimura M, Takanashi M, Okazaki H, Satake M, Nakajima K: Role of CD7 expressed in lung microvascular endothelial cells as Fc receptor for immunoglobulin M. Endothelium. (exbio.cz)
Occasional lymphocytes expressed CD4, CD5, CD8 and CD30, while staining for the B-cell marker CD20 and for CD56, activin receptor-like kinase 1 (Alk1) and T-cell receptor alpha/beta (TCR alpha/beta) was consistently negative. (upmc.edu)
The efficacy of cellular or humoral immunotherapy has been demonstrated with the success of chimeric antigen receptor T-cell therapy and the bispecific engager blinatumomab in treating advanced disease. (haematologica.org)
For these patients, cellular immunotherapy could help achieve deep leukemic clearance, although chimeric antigen receptor (CAR) T-cell strategies against T-cell cancers have been difficult. (ajmc.com)
The investigators then used base editing to inactivate 3 genes encoding CD52 and CD7 receptors and the b chain of the ab T-cell receptor to evade lymphodepleting serotherapy, CAR7 T-cell fratricide, and graft-versus-host disease, respectively. (ajmc.com)
Our previous work allowed the identification of the first positive marker for MF and SS cutaneous and circulating malignant T cells, namely the NK cell receptor KIR3DL2. (hipi-lab-saint-louis.fr)
By performing ex vivo experiments on circulating cells from Sézary patients, we established that KIR3DL2 was functional on tumor cells and acted as an inhibitory co-receptor. (hipi-lab-saint-louis.fr)
Moreover, although interleukin 7 (IL-7) supports the generation of such myeloid intermediates, we show that their developmental branching from the main intrathymic T-cell pathway is linked to the up-regulation of the myelomonocytic granulocyte macrophage-colony-stimulating factor (GM-CSF) receptor, to the down-regulation of the IL-7 receptor and to the lack of pre-T-cell receptor α (pTα) gene transcriptional activation. (ashpublications.org)
A keystone of the antigen-specific immune response is the T-cell receptor (TCR)/CD3 complex. (biomedcentral.com)
In addition, T cell receptor β gene rearrangement was detected by polymerase chain reaction analysis. (springeropen.com)
Moreover, the CD34 + CD38 - progenitor cells expressed variable amounts of the target receptor CD33, CD133 and c-kit (CD117) [ 20 ]. (researchsquare.com)
These cells had been gene-edited using new base-editing technology and fitted with a Chimeric Antigen Receptor (CAR) that allow them to recognise, hunt down and kill cancerous T-cells without attacking each other. (gosh.org)
Chimeric antigen receptor-modified T (CAR T) cells exhibit very effective function in elimination of relapsed/refractory B-cell lymphoid malignancies, we investigated their use in a patient with relapsed MCL. (bmj.com)
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. (cancer-genetics.org)
A costimulatory receptor that is specific for INDUCIBLE T-CELL CO-STIMULATOR LIGAND. (ouhsc.edu)
Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. (bvsalud.org)

MNKPL is characterized by extramedullary involvement, immature lymphoblastoid morphology without myeloperoxidase (MPO) reactivity, the CD7 + /CD33 + /CD34 + /CD56 + /HLA−DR + phenotype. (confex.com)

The blasts in MDS may show anomalous expression of CD56 and CD7. (medscape.com)
To explore correlations between CD7, CD34, CD56 and HLA-DR expressions and its prognosis among patients with acute myeloid leukemia. (biomedres.info)
CD7, CD34, CD56 and HLA-DR expressions of bone marrow among patients were detected. (biomedres.info)
Complete remission rate of CD7, CD34, CD56 and HLA-DR antigen expression positive among patients with Acute Myeloid Leukemia (AML) is low, mean survival is short and prognosis is poor. (biomedres.info)
There are reports showing that CD7, CD34, CD56 and HLA-DR expressions have a certain correlations with prognosis of patients with leukemia [ 7 - 9 ]. (biomedres.info)
Therefore, this study selects 225 patients with Acute Myeloid Leukemia (AML) in our hospital from Jan 2013 to Dec 2016 as study objects to explore CD7, CD34, CD56 and HLA-DR expression antigen and its relations with clinical effects and prognosis. (biomedres.info)
Immunohistochemical examination demonstrated that these accumulated lymphocytes mainly comprised small- to medium-sized T cells expressing CD3, CD4, CD5, CD7, and CD103, but lacking CD8, CD56, and Epstein-Barr virus-encoded small RNAs. (springeropen.com)

For example, low-intensity myeloperoxidase (MPO) expression has been noted in otherwise typical cases of B-cell ALL (B-ALL), and the 2016 WHO guidelines caution against making a diagnosis of B/myeloid MPAL in the absence of other evidence of myeloid differentiation. (medscape.com)
Chang H, Yeung J, Brandwein J, Yi QL: CD7 expression predicts poor disease free survival and post-remission survival in patients with acute myeloid leukemia and normal karyotype. (exbio.cz)
The maturing myeloid cells in MDS may show immunophenotypic abnormalities by flow cytometric immunophenotyping, as follows: a decrease in side light scatter properties (due to hypogranulosis), increased intensity of CD33 expression, persistence of CD33 to later myeloid stages, decreased CD10 expression, abnormal patterns of CD11b versus CD16 expression or CD13 versus CD16 expression, deviations in myeloid antigen intensity, dyssynchronous expression of 2 myeloid antigens, and aberrant nonmyeloid antigen expression. (medscape.com)
The exception are blasts with Auer Rod(s) which are unique to abnormal Myeloblast {16}s and abnormal promyelocytes as noted in some AMLs and APL Note: Abnormal lymphoblasts can show immunophenotypic abberancies (e.g. loss of T-cell antigens such as CD7, CD5 and CD2 or the gain of myeloid markers such as CD13, etc. (hematologyoutlines.com)
In this study, the finding that a significant proportion of all dendritic cells (DCs) resident in vivo in the human postnatal thymus displayed a myeloid-related phenotype prompted us to re-examine the developmental origin of thymic DCs, a cell type hitherto considered to represent a homogeneous lymphoid-derived population. (ashpublications.org)
We show here that these novel intrathymic DCs are truly myeloid, as they arise from CD34 + early thymic progenitors through CD34 lo intermediates which have lost the capacity to generate T cells, but display myelomonocytic differentiation potential. (ashpublications.org)
We also demonstrate that phenotypically and functionally equivalent myeloid precursors devoid of T-cell potential do exist in vivo in the postnatal thymus. (ashpublications.org)
1-3 These nonoverlapping functions have been proposed to result from the actions of 2 major DC populations which have been characterized as myeloid and lymphoid DCs, respectively, on the basis of their anatomical localization and cell-surface phenotypes and, ultimately, of their distinct developmental origin. (ashpublications.org)
8 As these latter DCs derive from an intrathymic lymphoid-restricted progenitor able to generate also T, B, and NK cells, but not myeloid cells, upon transfer in vivo, 5 , 9 , 10 they have hitherto been considered of lymphoid origin. (ashpublications.org)
Introduction: Myeloid/Natural killer (NK) cell precursor acute leukemia (MNKPL) is a rare hematologic malignancy prevalent in East Asia. (confex.com)
The most common aberrant antigen on acute myeloid leukemia (AML) was CD7, on precursor B lymphoblastic leukemia (B-ALL) was CD33 and on precursor T lymphoblastic leukemia (T-ALL) was CD13. (paom.pl)
Leukemia stem cells (LSCs) in acute myeloid leukemia (AML) played important roles in development of leukemia, chemotherapeutic drug resistance, and disease relapse and progression. (researchsquare.com)
Acute myeloid leukemia (AML) is generally regarded as a stem cell disease, and it originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity [ 1 , 2 ]. (researchsquare.com)

There was no association between sex/age and antigen aberrancy except a significant increase in CD34 loss on pre B acute lymphoblastic leukemia (pre B-ALL) and HLA-DR expression on acute promyelocytic leukemia (APL) in males compared to female patients and an increase of CD19 expression on non-APL-AML and an elevation of CD34 loss on T-ALL in adult compared to pediatric patients. (paom.pl)
We examined the CD45 dim CD34 + CD38 - CD133 + cells on bone marrow samples of hematologic malignancies and healthy controls using four-color flow cytometry experiments. (researchsquare.com)
Interestingly, the CD45 dim CD34 + CD38 - CD133 + cells were highly expressed in bone marrow of patients with AML compared to that of healthy controls (HC). (researchsquare.com)
Additionally, the high levels of the CD45 dim CD34 + CD38 - CD133 + cells in AML patients were an independently significant poor risk factor for overall survival and event free survivals. (researchsquare.com)
Therefore, our results suggest that CD45 dim CD34 + CD38 - CD133 + cells in AML might have the potential of leukemia stem cells. (researchsquare.com)
For examples, Rhenen et al showed that a high percentage of CD34 + CD38 - stem cells at diagnosis significantly correlated with a high minimal residual disease frequency and subsequently to relapse especially after the third course of chemotherapy in AML patients. (researchsquare.com)
Furthermore, it was developed using the basic platform of the CD34 + CD38 - markers, but applying more advanced antigens such as CD45 dim and CD133. (researchsquare.com)

Leucocyte Typing VI: White Cell Differentiation Antigens. (bdbiosciences.com)
igg relative increase in proliferation and differentiation into plasma cells. (themauimiracle.org)
Differentiation processes of cells have disorders, which stop the growth of cells. (biomedres.info)
Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells. (acrobiosystems.com)
CD1d-dependent expansion of NKT follicular helper cells in vivo and in vitro is a product of cellular proliferation and differentiation. (ouhsc.edu)
Within the B-cell and T-cell categories, two subdivisions are recognized: precursor neoplasms, which correspond to the earliest stages of differentiation, and more mature differentiated neoplasms. (medscape.com)

The antibody MEM-186 reacts with an extracellular epitope of CD7, a 40 kD type I transmembrane glycoprotein expressed on peripheral blood T lymphocytes, NK-cells, hematopoietic progenitors, monocytes (weakly) and also on acute lymphocytic leukemia. (exbio.cz)
Rat monoclonal antibody recognizing the CD4 mouse T-cell subset marker. (inserm-transfert.com)
This monoclonal antibody is directed against a fixative resistant T-cell associated antigen. (inserm-transfert.com)
the development of strategies by tumor cells to adapt and escape to antibody or protein inhibitors-based therapies. (hipi-lab-saint-louis.fr)
Our main goal is to identify new tumor antigens specifically expressed at the tumor cell surface and to validate their potential use as new therapeutic targets through the development of antibody-based immune-therapies. (hipi-lab-saint-louis.fr)
Our in vitro, ex vivo and in vivo results demonstrated that such antibody was able to promote depletion of the malignant cells by antibody-dependent cell-cytotoxicity or -phagocytosis. (hipi-lab-saint-louis.fr)
It's an antibody-based combination product to swiftly and safely remove hyper-reactive or misdirected T cells in patients suffering from T cell-mediated diseases like transplant rejection or certain autoimmune diseases . (labiotech.eu)
Flow cytometer detection was given after using monoclonal antibody of living cells immunofluorescent. (biomedres.info)
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)

[ 4 ] Cases of acute leukemia that may be classified in another category based on genetic or clinical features are also excluded (eg, AML with translocation t(8;21) and expression of multiple B-cell markers). (medscape.com)
Human acute myelogenous leukaemia cell line KG-1. (exbio.cz)
CD7 is also expressed on acute lymphocytic leukemia (ALL). (exbio.cz)
To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. (aacrjournals.org)
After more than four decades of intensive research, the cellular origins of acute lymphocytic leukemia (ALL) have been well defined, and several distinct genetic mechanisms that lead to malignant transformation of these cells have been identified ( 1 - 4 ). (aacrjournals.org)
Most children with T-cell acute lymphoblastic leukemia (ALL) can be treated with standard chemotherapy regimens, but patients with induction failure or elevated minimal residual disease after consolidation generally receive allogeneic stem-cell transplantation. (ajmc.com)
Finally, patient 3 is a 15-year-old boy who first presented with mixed-phenotype acute leukemia in 2016 and underwent a first allogeneic stem cell transplantation from a matched unrelated donor. (ajmc.com)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant neoplasm accounting for 10-15% of pediatric and 20-25% of adult cases. (lymphoblastic-hub.com)
The patient, 13-year-old Alyssa from Leicester, was diagnosed with T-cell acute lymphoblastic leukaemia (T-ALL) in 2021. (gosh.org)

CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. (exbio.cz)
Alaibac M, Pigozzi B, Belloni-Fortina A, Michelotto A, Saponeri A, Peserico A. CD7 expression in reactive and malignant human skin T-lymphocytes. (exbio.cz)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
The graft usually comes from a human leukocyte antigen (HLA)-matched donor and contains hematopoietic cells as well as immune cells, including T lymphocytes. (gvhdhub.com)

Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.cn)
T-Guard consists of two monoclonal antibodies ( mAbs ) that home in on CD3 and CD7. (labiotech.eu)
Blocking the interaction of the immune checkpoint molecule programmed cell death protein-1 and its ligand, PD-L1, using specific antibodies has been a major breakthrough for immune oncology. (snmjournals.org)

About 30% to 40% of PTCL, NOS, express markers of cytotoxic T-cells such as T-cell intracellular antigen-1 (TIA-1). (webpathology.com)
Immunohistochemically, the vast majority of the infiltrating cells stained positive for CD3 (Figure 6 ) and over half of them were positive for CD2 and T-cell intracellular antigen 1 (TIA1). (upmc.edu)

Flow Cytometric Immunophenotyping Is Sensitive for the Early Diagnosis of De Novo Aggressive Natural Killer Cell Leukemia (ANKL): A Multicenter Retrospective Analysis. (bdbiosciences.com)
We report 3 fatal cases of adult T-cell leukemia/lymphoma caused by human T-cell lymphotropic virus type 1 Australo-Melanesian subtype c. (cdc.gov)
Among HTLV-1 carriers in these regions, adult T-cell leukemia/lymphoma (ATLL) will ultimately develop in 1%-5% ( 2 ). (cdc.gov)
Expression of CD7 is an important marker used in leukemia diagnostics. (exbio.cz)
The use of base editing to generate universal, off-the-shelf CAR T cells is a promising approach for relapsed leukemia, with potential implications for the future of gene therapy. (ajmc.com)
New research in clustered regularly interspaced short palindromic repeats (CRISPR) technology suggests that base-edited T cells could be useful in patients with relapsed leukemia and could help anticipate the risks of immunotherapy -related complications. (ajmc.com)
These edited cells were investigated in 3 children with relapsed leukemia. (ajmc.com)
It used to be known as a bone marrow transplant, and it is performed to help fight leftover leukaemia cells in an effect known as Graft-versus-Leukemia (GVL) . (labiotech.eu)
Leukemia is a kind of malignant clone of hemopoietic stem cell disease, the reasons are apoptosis of leukemia cells are restricted, self-renewal of cells are higher than common cells and cell proliferation cannot be controlled. (biomedres.info)
An amount of leukemia cells spread and infiltrate into bone marrow and other hematopoietic tissue. (biomedres.info)
Immunophenotypes of leukemia can identify cells which cannot be identified by morphology, and it can promote diagnosis for leukemia and play a certain prognosis judgment [ 5 , 6 ]. (biomedres.info)
Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia. (sciencenet.cn)
HTLV-I infection can lead to the development of adult T-cell leukemia/lymphoma (ATLL) in 2-5% of infected individuals depending upon geographic location and exposure to etiologic factors. (biomedcentral.com)
In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
The superior clinical outcomes of allogeneic SCT versus chemotherapy alone as post-remission treatment could be related to the graft-versus-leukemia (GVL) effects of recovered donor T cells. (biomedcentral.com)
Allo-HSCT is an important treatment strategy, which allows administration of myeloablative therapy and the elimination of cancer cells by the transplanted donor T and natural killer (NK) cells in a phenomenon known as the graft- versus -leukemia (GvL) effect. (gvhdhub.com)

Binding of a tumor antigen via the scFv activates the T cell in a major histocompatibility-independent manner which leads to a cytotoxic response [ 3 ]. (nature.com)

A ligand of CD7, epithelial cell secreted protein K12, is produced in thymus to regulate thymocyte signaling and cytokine release. (exbio.cz)
Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma. (exbio.cz)
Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set. (cancer-genetics.org)
The B-cell-specific molecule CD72 is a natural ligand for CD5. (bvsalud.org)

One way to achieve this is to genetically modify immune cells, mainly T cells and recently also natural killer (NK) cells, to express chimeric antigen receptors (CARs). (nature.com)

Early patch-stage cutaneous T-cell lymphoma. (medscape.com)
Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
Our team has expertise in skin cancers, with a special interest in cutaneous T cell lymphoma, melanoma and carcinoma. (hipi-lab-saint-louis.fr)
Our team develops research projects dedicated to skin cancers with a main interest on melanoma, cutaneous T cell lymphoma (CTCL) and carcinoma. (hipi-lab-saint-louis.fr)
Mycosis Fungoides and Sézary syndrome are two forms of cutaneous T cell lymphoma associated to a poor prognosis at advanced stages due to a lack of curative treatments. (hipi-lab-saint-louis.fr)
Cutaneous T cell lymphoma (CTCL) is a heterogeneous group of non-Hodgkin lymphomas that originate from the skin. (hipi-lab-saint-louis.fr)
PD-L1 binding assays were performed using the transduced PD-L1-expressing lymphoma cell line U-698-M and wild-type U-698-M cells as a negative control. (snmjournals.org)
Background The aggressive form of Mantle cell non-hodgkin B cell lymphoma (MCL) has a dismal prognosis. (bmj.com)
Conclusions This case suggests that haplo-CAR T cell therapy can be effective in controlling lymphoma that failed to respond to autologous CAR T cell therapy and overcome limitation of autologous CAR T cells, thus may be one possible regimen before the era of off-the-shelf "universal" CAR T cell therapy. (bmj.com)
Mantle cell lymphoma (MCL) is a type of non-Hodgkin B cell lymphoma with a distinctive molecular marker cyclin D1 that is constitutively overexpressed in almost all cases. (bmj.com)

Most CAR-T cell-based gene therapy products that are under clinical evaluation consist of autologous enriched T cells, whereas CAR-NK cell-based approaches can be generated from allogeneic donors. (nature.com)
It arises in a hematopoietic stem cell and is characterized by the chromosomal translocation t(9;22)(q34.1;q11.2), which results in the formation of the Philadelphia ( Ph ) chromosome , containing the BCR-ABL1 fusion gene . (cancer.gov)
It is currently thought that tumors develop from a persistently infected T-cell reservoir, which can be amplified by cytokine-induced activation leading to viral gene expression, cellular proliferation and survival of some expanded cells. (biomedcentral.com)
Thanks in part to early funding from GOSH Charity, Professor Qasim has been a pioneer in developing new CAR T-cell treatments using innovative gene editing techniques. (gosh.org)
The Cancer Genome Atlas (TCGA) LUAD data set was used to explore associations among B-cell infiltration, PD-L1 expression, clinical outcome, and gene landscape. (cancer-genetics.org)

Eligible patients were divided into two cohorts: a high-risk first-relapse cohort of untreated patients with high-risk first-relapsed ALL and an expansion cohort of patients with refractory ALL, including multiple relapses, relapse after allogeneic hematopoietic cell transplantation, and induction failure. (bvsalud.org)
We report the case of a 12-year-old female patient with C1q deficiency presenting with intractable SLE who successfully underwent bone marrow transplantation from a human leukocyte antigen (HLA)-mismatched unrelated donor with an immunosuppressive conditioning regimen based on fludarabine, melphalan, and anti-thymocyte globulin. (bvsalud.org)
On day 27, the patient's bone marrow was hypocellular and in morphologic remission with undetectable minimal residual disease and she was discharged 52 days after stem-cell transplantation. (ajmc.com)
We're trying to treat patients suffering rejection following transplantation with allogenic hematopoietic stem cells - that is, cells derived from a donor rather than the patient. (labiotech.eu)
Herein, we report a case with a rare T cell PTLD, indolent T cell lymphoproliferative disease (LPD) in the gastrointestinal (GI) tract long after living donor liver transplantation (LDLT). (springeropen.com)
One patient treated with the gamma secretase inhibitor, BMS906024, achieved a complete hematologic response with a deep molecular response after two cycles, and one patient with R/R T-ALL treated with the NOTCH inhibitor CB-103 achieved a complete response (CR) within 1 week and progressed to allogeneic stem cell transplantation (allo-HSCT). (lymphoblastic-hub.com)
This study compared the effects of pre-transplantation minimal residual disease (pre-MRD) on outcomes in AML patients who underwent human leukocyte antigen-matched sibling donor transplantation (MSDT) or who received unmanipulated haploidentical allografts. (biomedcentral.com)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) involves the infusion of stem cells following administration of high-dose chemotherapy or total body irradiation for either tumor control or to prevent solid transplant rejection. (gvhdhub.com)
The patient received multiple molecularly targeted therapies, including targeting BTK and BCL2, and haplo-identical CAR T (haplo-CAR T) cells from her daughter without previous allo-hematopoietic stem cell transplantation. (bmj.com)

The WHO modification of the REAL classification of NHL is based on morphology and cell lineage. (medscape.com)

In double-negative thymocytes, the vast majority of 10D1+ cells were immature thymocytes of CD7+2+3- phenotype. (aai.org)
Although malignant cells were identified as a clonal expansion of CD4+ T cell with memory phenotype, their phenotypic detection relies on the loss of pan-T cell antigens such as CD26 or/and CD7. (hipi-lab-saint-louis.fr)
HTLV-I infected CD4 + T-cells lines usually progress towards a CD3 - or CD3 low phenotype. (biomedcentral.com)
The most common phenotype of PTLD is B cell lymphoproliferative disorder (LPD) associated with Epstein-Barr virus (EBV). (springeropen.com)

Normally, potentially malignant cells are continuously eliminated by the immune system, but cancer cells can accumulate certain mutations, which allow them to escape these mechanisms [ 2 ]. (nature.com)
CAR-modified immune cells are expanded until sufficient cell numbers are attained and are adoptively transferred into the patient to fight malignant cells. (nature.com)
We mainly focus our research activity on two types of CTCL: the Mycosis Fungoides (MF), where tumor cells accumulate in the skin, and the Sézary syndrome (SS), a highly aggressive form characterized by the presence of malignant cells in the skin and blood. (hipi-lab-saint-louis.fr)
Because 10% of Sézary patients display malignant T cells that do not express KIR3DL2, we pursue our search for specific tumor antigens. (hipi-lab-saint-louis.fr)
We recently reported that CD39, an ectonuclotidase involved in the process of generating adenosine from ATP, is aberrantly expressed by Sézary patients' malignant cells. (hipi-lab-saint-louis.fr)

This proposal is further supported by the finding that development of thymic DCs and T cells is linked via a common precursor at an early stage of thymocyte development. (ashpublications.org)

Although the histological classification and therapeutic strategy for post-transplant indolent T cell LPD have not been established, reducing immunosuppression allowed complete remission in our case. (springeropen.com)
Just 28 days after receiving the cells, Alyssa was in remission and went on to receive a second bone marrow transplant to restore her immune system. (gosh.org)

The team transduced healthy volunteer donor T cells using a lentivirus to express a CAR with specificity for CD7, which is expressed in T-cell ALL. (ajmc.com)

90% leukemic cells. (aacrjournals.org)
Not only detection of aberrant expression of CD markers in leukemic cells helps to estimate molecular abnormalities and has a prognostic effect, but also a specification of neoplastic cell markers at the time of diagnosis is essential for monitoring patients after treatment. (paom.pl)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Although mutation- or pathway-directed targeted therapy (e.g., using tyrosine kinase inhibitors to treat Philadelphia chromosome [Ph]-positive and Phlike B-cell-ALL) is currently available for only a minority of children with ALL, many of the newly identified molecular alterations have led to the exploration of approaches targeting deregulated cell pathways. (haematologica.org)

The affected brain tissue exhibited some reactive gliosis, mainly in the white matter, but no granulomas or plasmacytoid cells were detected. (upmc.edu)
Distinction between atypical lymphoid proliferations rich in Reed-Sternberg-like cells (reactive immunoblasts) and classic Hodgkin lymphomas. (medscape.com)

Expression and function of a 90-kilodalton homodimeric molecule (10D1 antigen) on human thymocytes. (aai.org)
These results indicate that, although the 10D1 Ag can be detected on the CD7+2+3-4-8- thymocytes, its functional expression is restricted to a minor more mature CD4+ thymocyte population as well as in peripheral blood T cells, and the implications of these findings are discussed. (aai.org)
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. (bvsalud.org)

He underwent lymphodepletion and received 1x106 BE-CAR7 T cells per kilogram. (ajmc.com)

CAR-expression on T or NK cells allows them to specifically target cancer cells via recognition of tumor associated antigens. (nature.com)
The addition of separate adapter molecules (AMs) specific for tumor antigens and CAR-immune cells targeting these AMs allows a more precise and temporally limited therapy. (nature.com)
Thereby, several antigens can be targeted at once and the therapy can be adapted in case antigen-loss tumor variants appear. (nature.com)
Expression of the activation marker CD30 may be seen in occasional tumor cells. (webpathology.com)
Notably, the pathophysiology of these diseases is still controversial especially regarding the tumor cell origin or the tumorigenic triggering factors. (hipi-lab-saint-louis.fr)

Peripheral T cell lymphomas (PTCLs) are generally chemotherapy resistant and have a poor prognosis. (mdpi.com)
In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)

However, the donor T cells that come with the stem cell graft might identify the healthy patient tissues as foreign and attack them in what is known as Graft-versus-Host Disease (GVHD). (labiotech.eu)

Furthermore, the so-called adapter CARs have been developed by splitting antigen recognition and CAR-immune cell activation. (nature.com)
The anti-CD3 one provides immunosuppression independent of the RTA-induced cell killing through its action on the CD3 complex, which plays a central role in the antigen recognition process. (labiotech.eu)

An effective immunomagnetic method for bone marrow purging in T cell malignancies. (covalab.com)
The lack of targeted immunotherapeutic approaches for T cell malignancies results in part from potential risks associated with targeting broadly expressed T cell markers, namely T cell depletion and clinically significant immune compromise. (mdpi.com)

CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. (exbio.cz)
Dendritic cells (DCs) are hematopoietic-derived highly specialized antigen-presenting cells (APCs) that display potent ability to induce both specific immune responses and deletion of potentially autoreactive T cells. (ashpublications.org)

Before undergoing lymphodepletion, 9% blasts were detectable in bone marrow and 0.3% blasts were observed immediately before infusion of 50x106 BE-CAR7 cells. (ajmc.com)
Despite reinduction therapy and 2 blocks of high-intensity chemotherapy, he had refractory disease that manifested as persistent cytopenia with more than 80% blasts in bone marrow, all of which were expressing CD7. (ajmc.com)
Blasts cells cannot be reliably distinguished from each other based on morphology alone. (hematologyoutlines.com)

Prior to infusion of the CAR-modified immune cells, lymphodepletion is performed in most therapeutic settings to allow efficient cell engraftment [ 10 ]. (nature.com)
Molecular chimerism analysis also confirmed the presence of BE-CAR7 cells, which the study said accounted for most of circulating mono-nuclear cells during the 28 days after infusion. (ajmc.com)

The patient was seropositive for HTLV-1 by Western blot and positive for hepatitis B surface antigen. (cdc.gov)
Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-human CD7 (MEM-186) PerCP. (exbio.cz)
[ 8 ] There is usually an increase in multidrug resistance glycoprotein (MDR-1) on the cell surface. (medscape.com)

Although these diseases arise from the transformation of different cell types (namely melanocytes, CD4+ T cell and epithelial cells), they share common features such as a partially elucidated pathophysiology, a lack of treatment at advanced stages, a need to understand the mechanisms leading to relapse or resistance upon currently available treatments and consequently a need for alternative therapies. (hipi-lab-saint-louis.fr)

MCL can be both indolent or aggressive, in either case it responds poorly to chemotherapy and consequently the aggressive form has a dismal prognosis assessed by incorporating Ki-67 proliferation index and Mantle Cell International Prognostic Index scores. (bmj.com)

In this study, we focused on measuring LSCs easily in the bone marrow cells from AML patients by developing a four-color flow cytometric analysis. (researchsquare.com)

Peripheral blood examination revealed lymphocytosis (22.4 × 10 9 /L) with atypical lymphoid cells. (cdc.gov)

The 10D1 Ag is a 90-kDa homodimeric molecule specifically expressed on a subpopulation of human T cells, and is involved in an alternative pathway of T cell activation. (aai.org)
Bringing a novel transplant-based medicine into clinical development in the U.S. has been a tremendous effort, and we are laser-focused on screening and site activation efforts to enroll our first sickle cell patient by year-end. (beamtx.com)
a leak is to calculate the mean tedizolid cmax was 154% and 69%, respectively, indicating that this sound is used primarily in the gency contraception have been discovered as a process called activation-induced cell death is a white, crystalline solid that is grown under careful control or when a methadone prescription increased their shared care schemes tagged onto established drug substances in sect. (themauimiracle.org)
Since dysregulation of calcium flux after T-cell activation has been suggested as a possible consequence of absence of CD3 expression[ 11 ]. (biomedcentral.com)

Haynes BF, Denning SM, Singer KH, Kurtzberg J. Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development. (bdbiosciences.com)
Human T-cell lymphotropic virus type 1 is endemic to central Australia among Indigenous Australians. (cdc.gov)
Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10 6 cells in a suspension. (exbio.cz)
Recombinant Human CD147 /EMMPRIN Protein (rhCD147), His Tag (CD7-H5222) is expressed from human 293 cells (HEK293). (proteinkinase.biz)
High and specific binding of 68 Ga-BMS-986192 to human PD-L1-expressing cancer cells was confirmed, which closely correlates with the respective PD-L1 expression level determined by flow cytometry and immunohistochemistry staining. (snmjournals.org)

In this review, we are going to take a closer look at the commercial CAR-T cell therapies, as well as on CAR-T and CAR-NK cell products, which are currently under evaluation in clinical trials, that are being conducted in Germany. (nature.com)
Clinical Flow Cytometric Analysis of Neoplastic Hematolymphoid Cells. (bdbiosciences.com)
In immune cell therapies, we have submitted our response to the FDA clinical hold for BEAM-201, and we continue our research toward a potential best-in-class platform for allogeneic cell therapies leveraging the strength of multiplex base editing, which may be the key to delivering deeper and more durable responses. (beamtx.com)

Anatomy32

Organisms9

Diseases4

Chemicals and Drugs157

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes31

Disciplines and Occupations1

Information Science3

Health Care1

Receptor19

Reactivity1

CD567

Myeloid13

CD347

Differentiation6

Antibody9

Acute9

Lymphocytes5

Antibodies3

Intracellular2

Leukemia17

Cytotoxic1

Ligand4

Receptors1

Lymphoma12

Gene5

Transplantation9

Lineage1

Phenotype4

Malignant5

Precursor1

Remission2

Specificity1

Leukemic2

Pathways2

Reactive2

Thymocytes3

Underwent1

Tumor5

Lymphomas2

Donor T cells1

Recognition2

Malignancies2

Induce2

Blasts3

Infusion2

Surface3

Epithelial1

Prognosis1

Bone Marro1

Lymphoid1

Activation4

Human5

Clinical3