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  • pathways
  • In repair mechanisms for DNA DSBs, there are two major pathways, non-homologous end joining (NHEJ) and homologous recombination (HR). In the NHEJ pathway, which is active during all phases of the cell cycle, DNA ends are joined with little or no base deletion at the end-joining site. (biomedcentral.com)
  • Apoptotic cell death can be mediated via several pathways. (aacrjournals.org)
  • There is recent evidence that the NF-κB-dependent gene expression of interleukin 8, interleukin 6, cyclooxygenase- 2, tumor necrosis factor and interleukin 33 in directly irradiated cells produced the cytokines and prostaglandin E2 with autocrine/paracrine functions, which further activated signaling pathways and induced NF-κB-dependent gene expression in bystander cells. (eurekaselect.com)
  • destroy
  • This means that the drugs travel through the bloodstream to reach and destroy cancer cells all over the body, including those that may have broken away from the primary tumour in the salivary gland. (cancer.ca)
  • Cesium Chloride has the ability to penetrate a cancer cell, destroy the enzyme systems, and not allow it to reproduce or survive. (cancertutor.com)
  • damage
  • Repair of sublethal damage (SLD), which indicates DSBs repair capacity, was measured as an increase of surviving cells after split dose irradiation with an interval of incubation. (biomedcentral.com)
  • The body uses it for cell growth and to protect cells from damage that could lead to cancer (see Question 1 ). (cancer.gov)
  • In addition, patients will have a portion of their blood cells modified by the insertion of a chemotherapy resistance gene which may help protect blood cells from damage by the combination of the Temozolomide and 06BG. (clinicaltrials.gov)
  • However, caspase-8 may digest the Bid protein to yield a truncated form that can induce mitochondrial damage, eventually leading to cell death. (aacrjournals.org)
  • Moreover, CD13 expression protected cells from DNA damage by regulating the levels of reactive oxygen species (ROS). (spandidos-publications.com)
  • Chemotherapy may cause side effects because it can damage healthy cells as it kills cancer cells. (cancer.ca)
  • Chemical irritation - Damage to the esophagus (from swallowing toxic chemicals or prior radiation therapy, for example) increases esophageal cancer risk. (womenshealthmag.com)
  • Generations of students in radiation biology have been taught that heritable biological effects require direct damage to DNA. (eurekaselect.com)
  • Hyperthermia, also called thermal therapy or thermotherapy, is a type of treatment during which body tissue is exposed to high temperatures of up to 113ºF in order to damage and kill cancer cells or to make cancer cells more sensitive to the effects of radiation and certain anticancer drugs. (cancertutor.com)
  • Apoptotic
  • Interestingly, Atg5-deficient dendritic cells significantly elevated receptor CD36 on the surface of the cells, which increased the phagocytosis of apoptotic tumor cells yet restricted the activation of T-cells. (news-medical.net)
  • In conclusion, jasmonates act directly on mitochondria derived from cancer cells in a PTPC-mediated manner, and could therefore bypass premitochondrial apoptotic blocks. (aacrjournals.org)
  • effects
  • In clonogenic survival assays, pretreatment of TAS106 showed radiosensitizing effects in various cell lines. (biomedcentral.com)
  • Although a significant radiosensitizing effect of TAS106 was observed in the parental V79 cells, pretreatment with TAS106 did not induce any radiosensitizing effects in BRCA2-deficient V-C8 cells. (biomedcentral.com)
  • growth assays showed effects of regimens combining Laromustine and radiation that were compatible with additive or subadditive interactions. (cylch.org)
  • Professor Heung Kyu Lee from the Graduate School of Medical Science and Engineering and his team found that the autophagy of dendritic cells plays a key role in T-cell activation and they proposed the principles of enhancing anti-cancer effects. (news-medical.net)
  • Then we review the prooxidant effects of various anticancer drugs including anthracyclines and bleomycin, platinum derivatives and the N- and S-mustards. (springer.com)
  • Successful transduction of hematopoietic cells with MGMTP140K makes them resistant to the toxic effects of both TEM + BG. (clinicaltrials.gov)
  • Systematic work in a broader panel of preclinical tumor models suggests that more than additive effects can be obtained with fractionated radiotherapy when the drug is given shortly before radiation. (springer.com)
  • Although radiation induced bystander effects have been well documented in a variety of biological systems, including 3D human tissue samples and whole organisms, the mechanism is not known. (eurekaselect.com)
  • hematopoietic
  • CD13 was first described as a marker for hematopoietic cells of myeloid origin. (spandidos-publications.com)
  • Since the first successful transplantation of umbilical cord blood in 1988, cord blood has become an important source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. (jci.org)
  • tumour
  • Growth and major histocompatibility antigen expression regulation by IL-4, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) on human renal cell carcinoma. (semanticscholar.org)
  • inhibition
  • Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression. (semanticscholar.org)
  • assays
  • Various cultured cell lines treated with TAS106 were irradiated and then survival fraction was examined by the clonogenic survival assays. (biomedcentral.com)
  • Compact disc4+ T cells producing interferon- are important for protection against infection and are the cornerstone of tuberculosis vaccination and immunological analysis assays. (cylch.org)
  • This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the traditional simple cell-based assays, often developed to study just single protein targets. (news-medical.net)
  • intestinal
  • CD13/Aminopeptidase N (APN) is a zinc-binding, type 2 transmembrane ectopeptidase (150 kDa), which is expressed on various cell types, such as kidney, intestinal epithelium, liver, placenta and lung cells ( 14 , 15 ). (spandidos-publications.com)
  • growth
  • The transcriptional activator interferon regulatory factor 1 (IRF-1) and its antagonistic repressor IRF-2 are regulators of the interferon (IFN) system and of cell growth. (nih.gov)
  • Esophageal cancer is the abnormal growth of cells in the esophagus. (womenshealthmag.com)
  • BRCA2
  • and Chinese language hamster VC8 cells (lacking in BRCA2) and control VC8 cells accompanied with the wild-type BRCA2 gene. (cylch.org)
  • lymphoma
  • It's a new approach, adding radiation to antibodies that search out a protein called CD20 found on lymphoma cells. (medindia.net)
  • This classification system is based on the Revised European-American Lymphoma (REAL) classification system which divides the lymphomas according to cell type and cell characteristics. (news-medical.net)
  • Mature T cell and natural killer (NK) cell neoplasia such as adult T cell leukemia/lymphoma, T cell prolymphocytic leukemia and primary cutaneous CD30-positive T cell lymphoproliferative disorders. (news-medical.net)
  • protein
  • An enzyme is a protein that speeds up the rate at which natural chemical reactions take place in cells of the body. (cancer.gov)
  • common
  • Table 1 gives a list of such drugs taken from a survey by Shaw 2 in 197O so it is by now certainly incomplete but is nevertheless an impressive list and includes many anticancer drugs in common use. (springer.com)
  • substance
  • The traditional word for the API is pharmacon or pharmakon which originally denoted a magical substance or drug. (reportsnreports.com)
  • Cannabis is not a substance, not a drug, not a herb -- simply a food and, as with all superfoods, it has healing properties. (cancertutor.com)