Cells and serum proteins. Medical search. Frequent questions

Throughout the last years, many serum proteins were been proposed as possible biomarkers for GvHD. (unicatt.it)
Blood serum and plasma are some of the largest sources of biomarkers, whether for diagnostics or therapeutics. (wikipedia.org)
For analysis of biomarkers in blood serum samples, it is possible to do a pre-separation by free-flow electrophoresis that usually consists of a depletion of serum albumin protein. (wikipedia.org)
We sought to confirm the prognostic importance of simple clinically available biomarkers of C-reactive protein, serum albumin, and ferritin prior to allogeneic hematopoietic cell transplantation. (haematologica.org)
24-Hour profile of serum sclerostin and its association with bone biomarkers in men. (cdc.gov)
The purpose of this study was to determine if serum sclerostin displays rhythmicity over a 24-h interval, similar to that of other bone biomarkers. (cdc.gov)
We examined the relationship between peripheral blood levels of SARS-CoV-2 S (Spike protein)1/M (Membrane protein)-reactive IFN-γ-producing CD4 + and CD8 + T cells, serum levels of biomarkers of clinical severity, and mortality in critically ill COVID-19 patients. (nature.com)
Many serum biomarkers have been evaluated in melanoma but their clinical significance remains a matter of debate. (hindawi.com)
In this paper, a review of the serum biomarkers for melanoma will be detailed and will be discussed from the point of view of their practical usefulness. (hindawi.com)
The expression of biomarkers can be detected intracellularly or on the cell membrane of melanoma cells or noncancer cells in association with the melanoma. (hindawi.com)
New serum biomarkers of melanoma progression and metastatic disease are still awaited in order to provide efficient rationale for followup and treatment choices. (hindawi.com)
To characterize biomarkers in neural tumors, we analyzed the acidic lipid fractions of 13 neural tumor cell lines using enzyme-linked immunoabsorbent assay (ELISA) and high-performance thin-layer chromatography (HPTLC) immunostaining. (karger.com)
Our data indicate that certain GSL antigens, especially SGGLs, GD3, and OAc-GD3, are expressed in neural tumor cells and may be considered as tumor-associated antigens that represent important biomarkers for neural tumors. (karger.com)
Lung measurements were performed with standard spirometry and new methods: airspace dimension assessment (AiDA), oscillometry, blood serum biomarkers (club cell. (lu.se)
Lung measurements were performed with standard spirometry and new methods: airspace dimension assessment (AiDA), oscillometry, blood serum biomarkers (club cell secretory protein 16, surfactant protein D, matrix metalloproteinases, fibroblast, hepatocyte growth factor, interleukins), and one urine biomarker (desmosine). (lu.se)
We concluded that the salivary TRAP has a potential to be use as biomarkers of pathologies and states that modify its activity in the serum. (bvsalud.org)

Lipoprotein electrophoresis determines the amount of proteins made up of protein and fat, called lipoproteins (such as LDL cholesterol). (medlineplus.gov)
citation needed] Serum is also used in protein electrophoresis, due to the lack of fibrinogen which can cause false results. (wikipedia.org)
Antiserum Albumin Blood fractionation Globulin Human serum albumin Lipid Serum iron Serum protein electrophoresis Serum-separating tube Serum total protein Martin, Elizabeth A., ed. (2007). (wikipedia.org)
To better understand the acute phase protein (APP) response in bongo and the high prevalence of amyloidosis, sera from 44 clinically normal bongo were tested by electrophoresis and for the APPs serum amyloid A and haptoglobin. (vin.com)
Serum protein electrophoresis (SPEP) is an easy, inexpensive method of separating proteins based on their net charge, size, and shape. (medscape.com)
[ 1 ] Globulins comprise a much smaller fraction of the total serum protein but represent the primary focus of interpretation of serum protein electrophoresis. (medscape.com)
Various disease states or conditions alter the pattern of proteins in electrophoresis (see Table 1 below). (medscape.com)

Human IgG antibody Laboratories manufactures the sheep serum reagents distributed by Genprice. (microarraystation.com)
NK cells are specialized effectors of the innate immune system that destroy their targets by antibody-dependent cell-mediated cytotoxicity, have prominent antitumor effects, and are potent killers of virally infected cells. (medscape.com)
Find blocking peptides and proteins for use as quality controls to confirm antibody specificity. (novusbio.com)
In addition, we have analyzed serum antibody titers against SGPG, GD3, and OAc-GD3 in patients with neural tumors by ELISA and HPTLC immunostaining. (karger.com)
Serum in a patient with subependymomas also had a high anti-SGGL antibody titer of the IgG and IgA types (titers over 12,800). (karger.com)
This corresponds to approximately 10 9 antibody-producing cells. (medscape.com)

Editorial Comment on: Inflammatory Protein Serum Amyloid A1 Marks a Subset of Conventional Renal Cell Carcinomas with Fatal Outcome. (lu.se)
Serum amyloid A (SAA) is an acute-phase protein, upregulated in sera of RA patients. (hindawi.com)
There was not a statistically significant difference in serum amyloid levels between normal (323.5±92.1 mg/L) versus abnormal (566.9±112.6 mg/L) animals. (vin.com)
Although there are more than 36 types of amyloid precursor proteins, only nine build up in the myocardium and cause cardiac amyloidosis. (medscape.com)

The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
2010-2011 rologic analysis found 4 recent cases (online Technical Appendix Figures 1 of HGA in Japan by using infected and 2), supporting the IFA results in THP-1 and HL60 cells as antigens, the Table. (cdc.gov)
In 4 of tive P44 proteins (online Technical patients in Japan reacted with antigens the patients, antibodies to A. phago- Appendix Figure 3) were produced of A. phagocytophilum cultured in cytophilum were detected in serum as recombinant proteins in vitro by THP-1 cells rather than in HL60 cells by using A. phagocytophilum cultured insect cell-free protein synthesis in IFA ( 2 ). (cdc.gov)
tation and laboratory findings for the 4 18ES for HL60) as antigens, most of The previous studies showed that A. patients are summarized in the online the serum from the patients was reac- phagocytophilum expresses predomi- Technical Appendix Table, (wwwnc. (cdc.gov)
ii) Blood-group antigens, red-cell antigens, human-leukocyte antigens, serum enzymes, serum proteins or red-cell enzymes. (delaware.gov)

For serodiag- Shizuoka Prefecture, Japan, who had frequently predominates by A. phago- nosis of HGA, A. phagocytophilum rickettsiosis-like symptoms, were sus- cytophilum cultured in HL60 cells ( 6 ) propagated in HL60 cells is usually pected to have Japanese spotted fever as representatives for the preparation used as an antigen, especially by in- or scrub typhus, but they were sero- of recombinant proteins. (cdc.gov)

Depending on animal strain, WF exposure and high-fat diet together worsened kidney toxicity as well as altered different serum enzymes and proteins. (cdc.gov)
Its roles include detoxification, protein synthesis, and producing digestive enzymes. (medicalnewstoday.com)
The purpose of this study was to investigate the activities of the total acid phosphatase (TAP), tartrate-resistant acid phosphatase (TRAP), low molecular weight protein tyrosine phosphatase (LMW-PTP) and alkaline phosphatase (ALP) enzymes, as well as the possible correlation in the serum and in unstimulated whole saliva of children. (bvsalud.org)
The enzymatic activities of all the studied enzymes were higher in serum than in saliva. (bvsalud.org)

[ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)

The 2 major types of protein present in the serum are albumin and the globulin proteins. (medscape.com)

The serum of convalescent patients successfully recovering (or already recovered) from an infectious disease can be used as a biopharmaceutical in the treatment of other people with that disease, because the antibodies generated by the successful recovery are potent fighters of the pathogen. (wikipedia.org)
To speak of multiple serum specimens from multiple people (each with a unique population of antibodies), physicians sometimes speak of sera (the Latin plural, as opposed to serums). (wikipedia.org)
Many paraneoplastic syndromes are triggered by an abnormal immune response where antibodies or a type of white blood cell called T cells attack and damage healthy cells. (healthline.com)
Vitamin C enhances production of white blood cells, raises interferon levels and increases production of antibodies - all very important to faster healing. (earthclinic.com)
All sera had high titers of antibodies of the IgM isotype against SGPG (titers over 1:3,200), especially in tumors such as meningiomas, germinomas, orbital tumors, glioblastomas, medulloblastomas, and subependymomas. (karger.com)

Acute phase response' is an innate defense mechanism that activates a variety of cellular and humoral components including, the changes in some serum proteins called 'acute phase protein (APP). (usda.gov)
In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
The protein composition of saliva also reflects cellular signal processing that results from day-to-day environmental influences, as well as from acute or chronic stress 9 . (bvsalud.org)

C-reactive protein and ferritin were centrally quantified by ELISA from cryopreserved plasma whereas each center provided pre-transplant albumin. (haematologica.org)
In multivariate analysis, transplant-related mortality was associated with the pre-specified thresholds of C-reactive protein more than 10 mg/L ( P =0.008) and albumin less than 3.5 g/dL ( P =0.01) but not ferritin more than 2500 ng/mL. (haematologica.org)
Optimal thresholds affecting transplant-related mortality were defined as: C-reactive protein more than 3.67 mg/L, log(ferritin), and albumin less than 3.4 g/dL. (haematologica.org)
The liver stores iron from hemoglobin in the form of ferritin, ready to make new red blood cells. (medicalnewstoday.com)
Serum levels of interleukin-6, ferritin, D-Dimer, lactose dehydrogenase and C-reactive protein in paired sera were known. (nature.com)
Ferritin is a protein inside your cells that stores iron. (mountsinai.org)
The amount of ferritin in the blood (serum ferritin level) is directly related to the amount of iron stored in your body. (mountsinai.org)

Objectives: To analyze surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF-MS) protein profiles of patients with head and neck squamous cell carcinoma (HNSCC) and healthy controls and to determine the sensitivity and specificity of SELDI assay for HNSCC detection before and after treatment. (johnshopkins.edu)
Results: The SELDI-TOF-MS assay generated serum protein profiles ranging from 0 to 100 kDa. (johnshopkins.edu)
National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
CHGA levels were also easily measured directly in serum using a simple ELISA assay after a blood draw, and lower levels in verapamil-treated subjects correlated with better endogenous insulin production as measured by mixed-meal-stimulated C-peptide, a standard test of Type 1 diabetes progression. (sciencedaily.com)

Materials and methods: We measured serum concentration of REG3α, ST2, B-cell activating factor (BAFF), CXCL9 and elafin in a cohort of 77 patients submitted to Hematopoietic allogeneic stem cell transplantation (HSCT) in our department. (unicatt.it)
In this study, we created the iMG cells from 14 patients with fibromyalgia and 10 healthy individuals, and compared the activation of iMG cells between two groups at the cellular level. (nature.com)
The expression of tumor necrosis factor (TNF)-α at mRNA and protein levels significantly increased in ATP-stimulated iMG cells from patients with fibromyalgia compared to cells from healthy individuals. (nature.com)
These rodent studies have indicated the over-activation of microglial cells in patients with chronic pain, however clinical molecular data are lacking due to ethical and technical issues. (nature.com)
We have already confirmed abnormalities in cellular responses of iMG cells derived from patients with Nasu-Hakola disease, which is a known primary microglia disease 14 . (nature.com)
Furthermore, we have analyzed the gene expression paterns of iMG cells in both manic and depressive state of patients with bipolar disorders, and revealed state-dependent microglial experession patterns 16 . (nature.com)
Main Outcome Measures: Serum samples were prospectively collected from 78 patients with HNSCC and 68 healthy control volunteers. (johnshopkins.edu)
Conclusions: Proteomic SELDI-TOF-MS analysis of serum protein profiles distinguishes patients with HNSCC from controls with a high degree of sensitivity and specificity. (johnshopkins.edu)
In 2010 and 2011, nine patients in 1 cells ( 2 ) and P44-18ES protein that tive study in Japan ( 2 ). (cdc.gov)
In IFA tests for HGA, IgM Shimadzu Co., Kyoto, Japan) ( 7 ) to multiple 44-kDa immunodominant and/or IgG from the patients' serum avoid the strong nonspecific reaction major outer membrane protein species samples reacted with A. phagocyto- with human serum that occurs in the (so-called P44) exists on the genome, philum cultured in THP-1, HL60, or Escherichia coli expression system. (cdc.gov)
and these multigenes are similar, but both, and the seroconversions were In Western blot analyses using these not identical, to each other, and the observed in convalescent-phase serum 3 recombinant P44 proteins (rP44-60 bacterium generates antigenic varia- from all patients. (cdc.gov)
To investigate whether oral protein supplements benefit bone metabolism in patients with recent hip fracture. (acpjournals.org)
Chen W, Tan Y, Ge Y, Chen Y, Liu X. The effects of levetiracetam on cerebrospinal fluid and plasma NPY and GAL, and on the components of stress response system, hs-CRP, and S100B protein in serum of patients with refractory epilepsy. (usp.br)
SARS-CoV-2 T cells (either CD4 + , CD8 + or both) were detectable in 70 patients. (nature.com)
SARS-CoV-2 IFN-γ CD4 + T-cell responses were documented more frequently than their CD8 + counterparts (62 vs. 56 patients) and were of greater magnitude overall. (nature.com)
The kinetics of both T cell subsets was comparable between those who died or survived, whereas anti-RBD IgG levels were higher across different time points in deceased patients than in survivors. (nature.com)
Enumeration of peripheral blood levels of SARS-CoV-2-S1/M-reactive IFN-γ CD4 + and CD8 + T cells does not predict viral clearance from the lower respiratory tract or poor clinical outcomes in critically ill COVID-19 patients. (nature.com)
Live Fetal Lamb Cells: over 50,000 patients have been treated at Clinic La Prairie in Switzerland with fresh fetal lamb cell injections. (selfgrowth.com)

Description: A competitive ELISA for quantitative measurement of Human True insulin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (microarraystation.com)
Munshi NC, Jagannath S. Plasma cell neoplasms. (medlineplus.gov)
It may be defined as blood plasma without the clotting factors, or as blood with all cells and clotting factors removed. (wikipedia.org)
Therefore, the aim of this research was to evaluate the platelet-rich plasma (PRP) as a supplement and scaffold for Vero cell culture, in a one case report study. (springer.com)
Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. (medscape.com)
[ 1 ] First described in 1848, MM is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance ( MGUS ) to plasma cell leukemia. (medscape.com)
Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
In AL amyloidosis, plasma cell dyscrasias produce kappa or lambda monoclonal light chains as an intact molecule or fragment, though the lambda isotope occurs in approximately 75%-80% of cases. (medscape.com)
It is derived from many small plasma proteins that form the biochemical cascade of the immune system. (dadamo.com)
A dense narrow band that is composed of a single class of immunoglobulins secreted by an abnormally expanded clone of plasma cells is known as M-protein (paraprotein, monoclonal protein or M-component). (medscape.com)
[ 3 ] Plasma cell disorders are typically associated with the presence of an M-protein (see Table 2 below). (medscape.com)

citation needed] Fetal bovine serum (FBS) is rich in growth factors and is frequently added to growth media used for eukaryotic cell culture. (wikipedia.org)
The evaluation of SPRP as a supplement showed that there was no statistical difference in cell viability compared to cultures supplemented in the standard way, with fetal bovine serum (FBS), after 24 h of culture. (springer.com)

An expression vector capable of encoding full-length CCAAT/enhancer-binding protein (C/EBP) has been constructed and tested in transient transfection assays for its capacity to activate transcription from the promoter of the serum albumin gene. (johnshopkins.edu)
Choose from hundreds of bioactive proteins for functional assays including cell proliferation assays, enzyme assays, or functional ELISAs. (novusbio.com)

No correlation was found between SARS-CoV-2 IFN-γ T-cell counts, anti-RBD IgG concentrations and biomarker serum levels (Rho ≤ 0.3). (nature.com)
A similar effect was observed on the airway-specific serum biomarker Clara cell protein 16 (CCP16). (nih.gov)

A Non-Aggressive, Highly Efficient, Enzymatic Method for Dissociation of Human Brain-Tumors and Brain-Tissues to Viable Single-Cells. (worthington-biochem.com)
Enzymatic activities were measured in pairs of concurrently obtained serum and salivary samples from 32 children in good oral and systemic health (16 of each sex) with a median age of 6.4 ± 3.3 years (range 1.08 - 12.92 years). (bvsalud.org)

Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)

In this classification, the only marker which has been incorporated for clinical use is lactate dehydrogenase (LDH) since elevated serum LDH has been shown in multivariate analysis to be an independent and highly significant predictor of survival even after accounting for site and number of metastases. (hindawi.com)

In general, alpha and gamma globulin protein levels increase when there is inflammation in the body. (medlineplus.gov)
The ROS/RNS react with oxidation-sensitive amino acids of proteins, especially tyrosine, forming nitrotyrosine as well as intramolecular and intermolecular dityrosine cross-links, both known as markers of inflammation and oxidative stress ( 9 - 15 ). (frontiersin.org)
Using avian models of experimental inflammation, induced by endotoxin and croton oil, we examined the changes in the serum proteins of chickens and found transferrin to be a major APP that was identical to ovotransferrin (OVT), an egg white protein. (usda.gov)
This study confirmed and extended data demonstrating the protective effect of FP against O(3)-induced airway inflammation and immune cell activation. (nih.gov)

Aims: We studied the trend of five of the most studied serum proteins to evaluate whether a correlation exists between proteins concentration and post-HSCT outcomes. (unicatt.it)

This lab test measures the types of protein in the fluid (serum) part of a blood sample. (medlineplus.gov)
To overcome this limitation, we have recently developed a technique to create human-induced microglia-like (iMG) cells from human peripheral blood monocytes. (nature.com)
Fresh blood is needed to produce iMG cells, and we can not stock iMG cells in the present stage, which is major limitations of our iMG technique. (nature.com)
Serum (/ˈsɪərəm/) is the fluid and solute component of blood which does not play a role in clotting. (wikipedia.org)
Serum does not contain white blood cells (leukocytes), red blood cells (erythrocytes), platelets, or clotting factors. (wikipedia.org)
Serum is used in numerous diagnostic tests as well as blood typing. (wikipedia.org)
To obtain serum, a blood sample is allowed to clot (coagulation). (wikipedia.org)
The sample is then centrifuged to remove the clot and blood cells, and the resulting liquid supernatant is serum. (wikipedia.org)
Look up serum or blood serum in Wiktionary, the free dictionary. (wikipedia.org)
An uncertainty factor of 3 for animal to human extrapolation because in vitro data show that human red blood cells are much less sensitive to the hemolytic effects of the 2-BUTOXYETHANOL metabolite, 2-butoxyacetic acid. (cdc.gov)
The liver or bone marrow stores iron released from hemoglobin, which makes the next generation of blood cells. (medicalnewstoday.com)
Albumin is the most common protein in blood serum. (medicalnewstoday.com)
Natural defense mechanism consists of many types of vigilant blood proteins and cells which kill the disease causing agents. (usda.gov)
We identified one such protein in chicken blood after artificial induction of a infection-like condition. (usda.gov)
To find its function we studied its effects on blood macrophages and heterophils, the cells that destroy bacteria. (usda.gov)
However, the livers still worked as proven by human liver proteins found in the rats' blood serum. (slashgear.com)
Complete blood cell counts and fibrinogen levels also were analyzed when available. (vin.com)
Benefits of the blood pressure medication verapamil include delayed disease progression, lowered insulin requirements and preservation of some beta cell function. (sciencedaily.com)
To examine changes in circulating proteins in response to verapamil treatment, the researchers used liquid chromatography-tandem mass spectrometry of blood serum samples from subjects diagnosed with Type 1 diabetes within three months of diagnosis and at one year of follow-up. (sciencedaily.com)
Arginine assists with the production of proteins in blood serum. (earthclinic.com)
It has also been found to be an antioxidant and to increase the formation of red blood cells. (earthclinic.com)
Iron is needed to make healthy red blood cells. (mountsinai.org)
Anemia is a condition in which the body does not have enough healthy red blood cells. (mountsinai.org)
Modulation of tight junction structure in blood-brain barrier endothelial cells. (worthington-biochem.com)
CryoStor and HypoThermosol ® , our cell and tissue storage and shipping media, are now incorporated into more than 220 pre-clinical validations and clinical trials of cell-based therapies, targeting blood cancers, solid tumors, vision loss, heart disease, stroke, and movement disorders such as osteoarthritis. (prnewswire.com)

Conclusions: Except for CXCL9, the protein levels seem to change according to GvHD development, independently from organ involvement and grading. (unicatt.it)
Protein repletion after hip fracture was associated with increased serum levels of insulin-like growth factor-I, attenuation of proximal femur bone loss, and shorter stay in rehabilitation hospitals. (acpjournals.org)
The aim of the present study was to investigate the usefulness of multidrug resistance protein 1 (MDR1) and neuropeptide Y (NPY) levels in predicting the efficacy of levetiracetam (LEV) plus oxcarbazepine (OXC) treatment administered to children with epilepsy and to determine their prognosis. (usp.br)
Serum MDR1 and NPY levels exhibited a high predictive value for early epilepsy diagnosis, treatment efficacy assessment, and prognostication in children with epilepsy treated with LEV plus OXC combination. (usp.br)
ABSTRACT This study evaluated peripheral eosinophil and serum eosinophilic cationic protein (s-ECP) levels as markers of asthma control. (who.int)
The potential association between SARS-CoV-2-S-Receptor Binding Domain (RBD)-specific IgG levels in sera and mortality was also investigated. (nature.com)
The first report in 2007, on SAA-stimulated human coronary artery endothelial cells (HCAEC), exhibited a substantial and significantly higher induction of released IL-6 protein and mRNA levels as compared to HUVEC [ 17 ], as well as increased responsiveness to IL-1 β [ 18 ]. (hindawi.com)
SAA dose-dependently increased IL-6 protein levels in HCAEC, to a much larger extent than in HUVEC (4-fold higher at a concentration of 1000 nM SAA). (hindawi.com)
CHGA is localized in secretory granules, including those of pancreatic beta cells, suggesting that changed CHGA levels might reflect alterations in beta cell integrity. (sciencedaily.com)
Also, serum CHGA levels in healthy, non-diabetic volunteers were about twofold lower compared to subjects with Type 1 diabetes, and after one year of verapamil treatment, verapamil-treated Type 1 diabetes subjects had similar CHGA levels compared with healthy individuals. (sciencedaily.com)
After an increase in serum levels of the free chains, the protein deposits in organs, causing significant dysfunction . (medscape.com)
Because of this association, the measurement of CD4+ T-cell levels has been used to establish decision points for initiating Pneumocystis carinii pneumonia prophylaxis (6) and antiviral therapy (7) and for monitoring the efficacy of treatment. (cdc.gov)
Welders had significantly higher respiratory system resistance assessed with oscillometry, serum levels of metalloproteinases 9 and hepatocyte growth factor, compared with controls. (lu.se)
The number of welding years correlated with decreased respiratory system reactance and increased serum levels of matrix metalloproteinases 9, interleukin 6, and hepatocyte growth factor. (lu.se)

These cells destroy disease-causing viruses, bacteria, or other microorganisms that might enter the liver through the gut. (medicalnewstoday.com)

Most of these proteins circulate as zymogens, which are inactive until proteolytic cleavage. (dadamo.com)

Fifty-three proteins showed significantly altered relative abundance over time in response to verapamil. (sciencedaily.com)

Molecular docking studies indicated that all three complexes primarily bind to HSA in subdomain IIA with amino acid residues such as Arg218 and Lys199 which are located at the entrance of Sudlow's site I. The in vitro cytotoxicities of complexes 1-3 against HeLa cells showed promising anticancer activity (IC 50 = 3.5, 3.9 and 16.9 μM for 1 , 2 and 3 , respectively). (rsc.org)

Acromegaly is characterized by the abnormal secretion of growth hormone and insulin-like growth factor 1 by cancer cells. (healthline.com)
DNA in the cells of the islets of Langerhans in the pancreas would normally contain that base sequence since the islets are the regions in which insulin is produced in mammals. (faqs.org)
Suppose, for example, that one wishes to insert the insulin gene into a bacterial cell. (faqs.org)
Type 1 diabetes is an autoimmune disease that causes loss of pancreatic beta cells, which produce endogenous insulin. (sciencedaily.com)

Cell cycle analysis by flow cytometry with HeLa cells indicated that 1 and 2 induced cell cycle arrest in the G2/M phase while 3 induced arrest in the G0/G1 phase leading to cell death. (rsc.org)
To determine the effect of FP on cellular function, we assessed sputum cells from seven subjects by flow cytometry for cell-surface marker activation. (nih.gov)
The fluorochrome-labeled cells are analyzed by flow cytometry, which categorizes individual cells according to size, granularity, fluorochrome, and fluorochrome intensity. (cdc.gov)

Scientists found that the precise arrangement (or sequence) of nitrogen bases A, C, G. and T on the DNA strand is the recipe that codes for the manufacture of specific chemical compounds, namely proteins. (faqs.org)

Protein malnutrition may contribute to the occurrence and outcome of hip fracture. (acpjournals.org)

Microglia are immune cells in the CNS, and known to have inflammatory functions via releasing proinflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β 6 . (nature.com)
Natural-killer (NK) cells are specialized lymphocytes that have cytotoxic properties in addition to their ability to produce cytokines that assist in the orchestration of adaptive immunity. (medscape.com)
1: In the haematopoietic microenvironment, bone marrow stromal cells play an important role in regulating haematopoiesis by expressing various cytokines, including leukaemia inhibitory factor (LIF) and interleukin-6 (IL-6). (unboundmedicine.com)
4: Expression of a dominant-negative mutant form of JNK1 that blocked FCS-induced JNK activity had no effect on protein production and gene expression of these cytokines. (unboundmedicine.com)

TissueGene has completed Phase 2 trials and has reached an agreement with the U.S. Food and Drug Administration regarding a Special Protocol Assessment (SPA) on the design, endpoints and statistical analysis plan for a Phase 3 clinical trial for Invossa, an allogeneic cell therapy for osteoarthritis of the knee. (prnewswire.com)
BioLife's enabling technology provides commercial companies and clinical researchers significant improvement in shelf life and post-preservation viability and function of cells, tissues, and organs. (prnewswire.com)
The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. (sumobrain.com)

C(H)-C 6 H 4 OH- o , o -phen = 1,10-phenanthroline, and OAc = CH 3 COO − ) with human serum albumin (HSA) was studied using fluorescence quenching, synchronous and 3D fluorescence measurements and UV-vis spectroscopy. (rsc.org)
The Sheep Serum reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (microarraystation.com)
2: Transformed human bone marrow stromal cells (HS-5) were stimulated with foetal calf serum (FCS) to produce LIF and IL-6. (unboundmedicine.com)
Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. (springer.com)
Autologous human serum for cell culture avoids the implantation of cardioverter-defibrillators in cellular ardiomyoplasty. (springer.com)
When the genetic material within the living cells, i.e. genes are working properly, the human body can develop and function smoothly. (faqs.org)
Using cells scraped from a person's skin, researchers grew miniature human livers in a lab and then successfully transplanted them into living rats. (slashgear.com)
To determine the effects of medications on SAA-stimulated human coronary artery endothelial cells (HCAEC). (hindawi.com)
We are also finding many ways to get old human cells to behave like young ones do. (selfgrowth.com)
Sulfated glucuronosyl glycosphingolipids (SGGLs) are cell surface molecules that are endowed with the Human Natural Killer-1 (HNK-1) carbohydrate epitope. (karger.com)
Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics. (worthington-biochem.com)

Proteins are made from amino acids and are important parts of all cells and tissues. (medlineplus.gov)

Another merit is that we can produce iMG cells without any gene modification. (nature.com)
3: Both PD98059 (MAPK/ERK kinase inhibitor) and SB203580 (p38 MAPK inhibitor) attenuated FCS-induced LIF protein production and gene expression. (unboundmedicine.com)
CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. (johnshopkins.edu)
Dive into the research topics of 'CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. (johnshopkins.edu)
The technique required three elements: the gene to be transferred, a host cell in which the gene is to be inserted, and a vector for transferring the gene to the body. (faqs.org)
In the blast phase, blast cells showed early B-cell phenotype (CALLA +, Ia +, TdT+) with a rearranged immunoglobulin heavy-chain gene joining region (JH). (karger.com)
According to Kolon, Invossa is the world's first cell-mediated gene therapy for osteoarthritis, a degenerative joint disease affecting more than 150 million people. (prnewswire.com)
Kolon Life Science has been developing innovative cell and gene therapies including Invossa, the world's first cell-mediated gene therapy for osteoarthritis, since its founding in 2000. (prnewswire.com)

Changes of the protein structure and other properties due to nitration and oligomerization can alter the allergenic and inflammatory potential of a protein affecting both, the process of sensitization and the response phase of an allergy ( 9 , 10 , 25 - 31 ). (frontiersin.org)

This suggests that in contrast to CTX, serum sclerostin could be measured at any time of day. (cdc.gov)
In contrast, fucosyl-GM1 was not found to restrict to small cell lung carcinoma cells. (karger.com)

The roles of the liver include detoxification, protein synthesis, and the production of chemicals that help digest food. (medicalnewstoday.com)

This occurs when tumor cells cause an overproduction of the hormone cortisol. (healthline.com)

Small cell lung cancer (SCLC) makes up about 15% of lung cancers in the United States. (healthline.com)
It is also one of the two main divisions of lung cancer along with non-small cell lung cancer. (healthline.com)

The complement system influence the activity of numerous cells, tissues and physiological mechanism of the body. (dadamo.com)
These cells carry oxygen to body tissues. (mountsinai.org)
BioLife Solutions develops, manufactures and markets biopreservation media products and smart shipping containers connected to a cloud hosted cold chain management app to improve the quality of delivery logistics for cells, tissues, and organs. (prnewswire.com)

Autologous platelets as a source of proteins for healing and tissue regeneration. (springer.com)
Target cells for MAC action may be heterologous erythrocytes, nucleated cells (autologous or foreign), bacteria (Gram-negative, susceptible to serum), microscopic fungi, viruses with a surface envelope and virus-infected cells. (dadamo.com)
The result of cytotoxic complement reaction may be beneficial for the body (elimination of the infectious agent or damaged cells) or harmful (damage to autologous normal cells by immunopathological reactions). (dadamo.com)

Activation of immune cells in the brain called microglia has attracted attention as a potential underlying pathological mechanism in chronic pain. (nature.com)
The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)
Other cellular components of the innate immune system include mononuclear phagocytes, dendritic cells, and NK cells. (medscape.com)
These syndromes can form when your immune system attacks healthy neurological cells. (healthline.com)
Cells involved in immune activity, Kupffer cells, are found in high numbers in the liver. (medicalnewstoday.com)
These included proteins known to be involved in immune modulation and autoimmunity of Type 1 diabetes. (sciencedaily.com)
Vitamin A and beta-carotene (its pro-vitamin form) is a potent antioxidant, helps protect against infection and causes immune cells to function more efficiently. (earthclinic.com)
Green tea 'turns on' immune cells and may help to prevent bacterial infections. (earthclinic.com)
These receptors, present on the other cells of the immune system, are involved in a variety of immunoregulatory reactions. (dadamo.com)
Ozone exposure induces airway neutrophilia and modifies innate immune monocytic cell-surface phenotypes in healthy individuals. (nih.gov)

Protein phosphatases reverse the covalent modifications of numerous cellular proteins imposed by the activation of protein kinases and, therefore, play key role in cell signaling metabolism, growth and differentiation. (bvsalud.org)

Successful outcomes following allogeneic hematopoietic cell transplant (HCT) may be offset by risks of transplant-related morbidity and mortality. (haematologica.org)

Background: GvHD is one of the major complication after stem cell transplantation affecting transplant-related mortality. (unicatt.it)

Ehrenfest DMD, Del Corso M, Diss A, Mouhyi J, Charrier J-B. Three-dimensional architecture and cell composition of a Choukroun's platelet-rich fibrin clot and membrane. (springer.com)

Besides modification by ONOO - , the tyrosine residues of the proteins can also be modified directly in the environment. (frontiersin.org)

Methods: Serum sclerostin, FGF-23, CTX, and P1NP were measured every 2 h over a 24-h interval in ten healthy men aged 20-65 years. (cdc.gov)

Depletion of oMAP4 impairs cell elongation and cell-cell fusion. (elifesciences.org)

A combination of FBS and the cytokine leukemia inhibitory factor was originally used to maintain embryonic stem cells, but concerns about batch-to-batch variations in FBS have led to the development of serum substitutes. (wikipedia.org)

1 Traditional factors used to gauge transplant risks include conditioning regimen intensity, 2 immunosuppression and HLA matching, 3 along with hematopoietic cell source, and graft cell yield. (haematologica.org)
6 Comorbidity determined by the hematopoietic cell transplantation-comorbidity index (HCT-CI), 7 predicts for worse survival, generally through higher TRM. (haematologica.org)

Effect of fiber diameter on spreading, proliferation, and differentiation of osteoblastic cells on electrospun poly (lactic acid) substrates. (springer.com)
The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation. (springer.com)
The microtubule cytoskeleton is critical for muscle cell differentiation and undergoes reorganisation into an array of paraxial microtubules, which serves as template for contractile sarcomere formation. (elifesciences.org)
We show that oMAP4 is expressed upon muscle cell differentiation and is the only MAP4 isoform essential for normal progression of the myogenic differentiation programme. (elifesciences.org)
Upon differentiation, mono-nucleated myoblasts withdraw from the cell cycle and fuse to form syncytial myotubes ( Wakelam, 1985 ). (elifesciences.org)

Humans, Japan, cally from that in HL60 cells. (cdc.gov)

Insome cases, a single misspelled base is sufficient to cause a disease, suchas sickle cell anemia. (faqs.org)

Therefore, in Vero cell cultures, the results suggest that SPRP and CPRP can be used as a supplement and scaffold, respectively. (springer.com)
Novus offers nearly 50,000 highly purified peptides and proteins that consistently produce robust and reliable results. (novusbio.com)
Our results show that this protein can stimulate those cells to produce factors that boost defense mechanisms. (usda.gov)
Using an enzyme-immunoassay, the results showed serum OVT to be elevated during a variety of bacterial and viral infections. (usda.gov)
The study was recently published in Cell Reports , where researchers detail the experiment and its results. (slashgear.com)
These results suggest that serum sclerostin can be measured at any time of day and the osteocyte does not direct the rhythmicity of other BTMs in men. (cdc.gov)

Anatomy12

Organisms13

Diseases28

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment64

Phenomena and Processes38

Disciplines and Occupations2

Technology, Industry, Agriculture2

Information Science2

Health Care10

Biomarkers16

Electrophoresis7

Antibody6

Amyloid4

Antigens6

Recombinant proteins1

Enzymes4

Complement proteins1

Globulin proteins1

Antibodies5

Acute4

Ferritin7

Assay4

Patients18

Plasma11

Fetal2

Assays2

Biomarker2

Enzymatic2

Antigen1

Lactate dehydrogenase1

Inflammation4

Correlation1

Blood25

Levels14

Microorganisms1

Zymogens1

Significantly1

Vitro1

Insulin4

Flow cytometry3

Chemical Compounds1

Malnutrition1

Cytokines4

Clinical3

Human11

Amino acids1

Gene8

Inflammatory1

Contrast2

Synthesis1

Tumor cells1

Lung2

Tissues3

Autologous3

Immune10

Cellular1

Outcomes1

Transplant-related mortality1

Membrane1

Tyrosine1

Methods1

Depletion1

Embryonic stem1

Hematopoietic cell2

Differentiation5

Humans1

Sickle cell a1

Results6