• the remodeling endothelial cells. (exposed-skin-care.net)
  • Mast cells are found frequently in close proximity to blood vessels, and endothelial cells are likely to be exposed to high concentrations of their granule mediators. (eurekamag.com)
  • Leukocyte accumulation in response to tryptase may be mediated in part through the selective secretion of IL-8 from endothelial cells. (eurekamag.com)
  • Release of PDGF-BB and bFGF by human endothelial cells seeded on expanded polytetrafluoroethylene vascular grafts. (bvsalud.org)
  • Usually, however, some tumor cells persist - and may change their behavior in response to other cells' deaths. (cancer.gov)
  • It's almost like dying tumor cells give some sort of last words to the live tumor cells so those cells can survive better," Yang says. (cancer.gov)
  • In mice, Yang's team found that the contents released from burst nuclei triggered growth-promoting signaling in nearby mammary tumor cells and accelerated the growth of metastatic tumors. (cancer.gov)
  • According to Jonathan Keats, Ph.D . , Director of Bioinformatics at TGen, Scientific Director of the Judy and Bernard Briskin Center for Multiple Myeloma Research at City of Hope, and a co-author on the paper, the currently approved T cell therapies target either B cell maturation antigen (BCMA) or the GPRC5D protein on the surface of tumor cells. (tgen.org)
  • Exosomes microvesicles of endocytic source released by normal and tumor cells play an important role in cell-to-cell communication. (exposed-skin-care.net)
  • PHILADELPHIA - Bispecific anti-CD19/CD20 chimeric antigen receptor (CAR) T-cell therapy was well tolerated and showed signs of clinical efficacy in patients with relapsed/refractory B-cell lymphoma, according to phase I clinical trial data presented during Week 1 of the virtual AACR Annual Meeting 2021 , held April 10-15. (aacr.org)
  • Anti-CD19 CAR T-cell therapy has revolutionized the management of this disease in recent years, but it still has several limitations," she noted, explaining that approximately half of patients relapse within six months of starting the treatment due to a lack of CAR T-cell persistence and/or downregulation of the target antigen, CD19, on the tumor. (aacr.org)
  • We hypothesized that this approach might increase CAR T-cell persistence and expansion in the patient, while limiting relapses due to loss of the tumor antigen. (aacr.org)
  • The presented analysis included five patients with B-cell malignancies that were positive for both CD19 and CD20 tumor antigen expression. (aacr.org)
  • TBX also inhibited antigen-induced histamine release from lung fragments of actively immunized animals. (unboundmedicine.com)
  • After immunization of rats with sheep red blood cells (SRBC, a T cell-dependent antigen), an increase of hypothalamic TRH messenger RNA (mRNA) was observed at 4-24 h post immunization, in contrast to the decrease observed after treatment with lipopolysaccharide (LPS). (bris.ac.uk)
  • Chimeric antigen receptor (CAR) T-cell therapy is a rapidly growing treatment modality. (medscape.com)
  • Chimeric antigen receptors (CARs) are synthetic proteins expressed on the surface of T cells. (medscape.com)
  • It has been known for many years that pancreatic beta cells, which produce insulin, have many signaling receptors and a molecular composition that are similar to neurons. (labroots.com)
  • The first season of Cells At Work was released in 2018 and was really loved by the fans. (world-wire.com)
  • During bacterial infection, autophagy proteins appear to regulate the release of cell-saving exosomes, which bear the brunt of toxin damage. (the-scientist.com)
  • PUNCTURE THIS: Based on experiments with mice and cultured human epithelial cells, researchers pieced together how hosts can use exosomes to defend themselves against bacterial toxins. (the-scientist.com)
  • In wild-type mice, host cells respond by releasing exosomes studded with the protein ADAM10, which act as decoys, but mice deficient in an autophagy protein called ATG16L1 release far fewer of the decoy exosomes (2), indicating the autophagy protein is necessary to mount an effective exosome response. (the-scientist.com)
  • Indeed, while MRSA's alpha-toxin binds the host receptor ADAM10 on exosomes in wildtype mice, destroying the vesicles, in mice lacking ATG16L1, alpha-toxin binds ADAM10 on host cells, forming a pore and killing cells (3). (the-scientist.com)
  • Further experiments revealed that ATG16L1 and other autophagy proteins regulated the cultured cells' release of exosomes, small bubbles of cytosol wrapped in plasma membrane and studded with the cell's own proteins. (the-scientist.com)
  • The presence of bacteria, particularly their DNA, was necessary for the release of exosomes from the cell, the team found. (the-scientist.com)
  • When the cultured cells had normal levels of autophagy proteins and were exposed to bacterial DNA, they released far more exosomes laden with ADAM10 than did the ATG16L1-deficient cells. (the-scientist.com)
  • Exosomes also protected other cells from two additional bacterial toxins, leukotoxin ED and diphtheria toxin. (the-scientist.com)
  • ATCC announced the first launch from a portfolio of exosomes ( i.e. , extracellular vesicles) derived from human cells to serve as reference materials or standards for a variety of research applications. (atcc.org)
  • The first two exosomes available to researchers are derived from the A549 non-small cell lung cancer (NSCLC) cell line and hTERT-immortalized mesenchymal stem cells. (atcc.org)
  • Exosomes are extracellular vesicles that carry cell-free cargo such as DNA, RNA, bioactive lipids, and proteins, thereby making them an attractive tool for diagnostic and drug development. (atcc.org)
  • For example, exosomes from cancer cells may carry genetic biomarkers that could potentially be used to develop tests for the early detection of cancer. (atcc.org)
  • ATCC's exosomes are derived from authenticated ATCC cells, long considered the gold standard of whole-cell reference materials. (atcc.org)
  • The other current release, exosomes from hTERT-immortalized mesenchymal stem cells, could potentially be used in several different applications, including research in drug delivery, wound healing, and immune stimulation. (atcc.org)
  • A new exosomes study released today in STEM CELLS may lead to a welcomed solution in the future. (stemcellsportal.com)
  • This study demonstrates how exosomes, sacs of cell membrane in the body that shuttle proteins and genetic information between cells, and exosome-educated macrophages (EEMs), a type of white blood cell that typically kills microorganisms and removes dead cells, but also could stimulate the action of other immune system cells, can promote ligament healing and reduce scarring. (stemcellsportal.com)
  • Labeling and internalization of exosomes Exosomes fromK562 cells had been tagged using PKH26 (reddish colored) or PKH67 (green) membrane-binding fluorescent brands relating to manufacturer's suggestions (Sigma-Aldrich Allentown PA). (exposed-skin-care.net)
  • HUVECs seeded on Matrigel-coated chamber slides (Thermo Scientific Inc. Rochester NY) had been incubated at 37°C with tagged exosomes at a focus of 1 1 μg exosomes/10 0 cells or as described. (exposed-skin-care.net)
  • Where indicated two labeled populations of HUVECs were generated after incubation of the cells in UF010 standard culture monolayer for 3 h with PKH26- or PKH67-labeled exosomes. (exposed-skin-care.net)
  • Durham, NC (November 09, 2020) - A new study released today in STEM CELLS might just have solved the mystery behind why mesenchymal stem cells (MSCs) continue to suppress inflammation in the body long after the MSCs are cleared from the system. (stemcellsportal.com)
  • The study demonstrates that fibulin 5, a protein secreted by human Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs), plays an important role in the development of Schwann cells in the peripheral nervous system (PNS). (stemcellsportal.com)
  • Cells At Work: Code Black is all set to release in January 2021 in Japan and interestingly the second season of Cells At Work will release in the same time window. (world-wire.com)
  • Reference: "Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron" by Takuya Hikima, Christian R. Lee and Paul Witkovsky, 6 April 2021, Cell Reports . (scitechdaily.com)
  • Telecom operators are expected to deploy small cell solutions in mmWave bands, which boost the deployments of outdoor small cells post 2021. (express-press-release.net)
  • Cell therapy is a transformative cancer treatment that utilizes genetically modified cells from a healthy donor or patient's own immune system to attack cancer cells, but manufacturing these cells represents a major challenge for the industry. (brighttalk.com)
  • The genetically modified autologous T cells are expanded in vitro at a production facility and then reinfused into the patient. (medscape.com)
  • PKCa and PKCe activities were inhibited using isoform-specific pharmacologic inhibitors and genetically modified dominant-negative (DN) expressing cell lines. (cdc.gov)
  • The team found that the innate immune receptor TLR9 senses bacterial DNA in human and mouse cells and triggers exosome release, although the team hasn't yet determined all the steps in the pathway. (the-scientist.com)
  • All patients had grade 1 cytokine release syndrome, and all responding patients had ongoing B-cell aplasia at the time of data cutoff. (aacr.org)
  • Dust samples collected from Nebraska swine confinement facilities (hog dust extract [HDE]) are known to elicit proinflammatory cytokine release from human bronchial epithelial (HBE) cells in vitro. (cdc.gov)
  • Experiments were designed to investigate the relationship between the two isoenzymes and the degree to which each is responsible for cytokine release in HBE. (cdc.gov)
  • Both IL-6 and IL-8 release are likewise diminished under these conditions compared with normal HBE, and treatment with TNF-a neutralizing antibody does not further inhibit cytokine release. (cdc.gov)
  • Durham, NC (Sept. 15, 2020) - Human pluripotent stem cells (hPSCs) hold promise in the field of regenerative medicine for how they give rise to every other cell type in the body and for their ability to propagate indefinitely. (stemcellsportal.com)
  • LONDON--( BUSINESS WIRE )--Tenpoint Therapeutics ("Tenpoint"), a biotechnology company pursuing vision-restoring engineered cell-based therapeutics and in vivo reprogramming to address degenerative ocular diseases, today announced its launch with a $70 million Series A financing to develop its regenerative medicine platform to replace multiple cell types lost to inherited and age-related conditions. (businesswire.com)
  • The researchers' first step was to watch cancer cells under a microscope as they underwent apoptosis. (cancer.gov)
  • In an article in Nature , researchers indicate that one option for improving oversight may be repurposing the Embryonic-Stem-Cell Research Oversight (ESCRO) committee, in order to take a more expansive role in research supervision. (biopharminternational.com)
  • Instead, researchers should "call on the existing human subjects review processes to oversee donor cell recruitment," ISSCR wrote in a press announcement . (biopharminternational.com)
  • The Allen Institute for Brain Science, a division of the Allen Institute, today announced new data aimed at helping researchers understand the various types of cells in the brain and how cells compute visual information. (alleninstitute.org)
  • Allen Institute researchers have looked across six different regions of the mouse visual cortex, and the dataset now also includes cells in the deepest layers of the mouse visual cortex. (alleninstitute.org)
  • These data are a central part of an ongoing effort to create a "periodic table" of brain cell types, allowing researchers to understand the brain by better understanding its fundamental building blocks - the cells. (alleninstitute.org)
  • Such "self-regulation," the researchers say, stands in contrast to the widely held view that the release of dopamine - known as the "feel good" hormone - by any cell relied on messages from nearby cells to recognize that it is releasing too much of the hormone. (scitechdaily.com)
  • Led by researchers at NYU Grossman School of Medicine, the new study showed that dopamine-releasing brain cells respond to their own signals to regulate the hormone's output. (scitechdaily.com)
  • Because the death of dopamine-releasing brain cells is a key factor in Parkinson's disease, the new findings provide insight into why these cells die in the movement disorder, the researchers say. (scitechdaily.com)
  • By injecting Botox into single neurons, says Hikima, the researchers hoped to show whether any signal to continue or stop dopamine release could only come from outside the "paralyzed" cell. (scitechdaily.com)
  • This rejection is due to the body's immune system labeling the cells as "foreign invaders" and setting in motion a series of strategies intended to ward off what it deems an attack - leaving researchers scrambling for a way around this protective measure. (stemcellsportal.com)
  • In fact, up to 65% of relapsing multiple myeloma patients could be affected by mutations that impact targeted T cell treatments, according to the study authors, including researchers from the Translational Genomics Research Institute (TGen), part of City of Hope, and City of Hope , one of the largest c ancer research and treatment organizations in the United States. (tgen.org)
  • New work reported in Developmental Cell by researchers at Johns Hopkins University has demonstrated that a protein known to control nerve cell development also acts on the pancreas, prompting the release of insulin. (labroots.com)
  • Ultra-high efficiency solar cells similar to those used in space may now be possible on your rooftop thanks to a new microscale solar concentration technology developed by an international team of researchers. (eurekalert.org)
  • To enable CPV on rooftops, the researchers combined miniaturized, gallium arsenide photovoltaic cells, 3D-printed plastic lens arrays and a moveable focusing mechanism to reduce the size, weight and cost of the CPV system and create something similar to a traditional solar panel that can be placed on the south-facing side of a building's roof. (eurekalert.org)
  • To focus sunlight on the array of cells, the researchers embedded them between a pair of 3D-printed plastic lenslet arrays. (eurekalert.org)
  • By sandwiching the cells between the lenslet arrays, the researchers solved this problem and enabled efficient solar focusing for a full eight hour day with only about 1 centimeter of total movement needed for tracking. (eurekalert.org)
  • The first national estimate on the health status of children with sickle cell disease revealed that black children with sickle cell disease are more likely to have intellectual disabilities, hearing deficits, and frequent severe headaches or migraines than black children without sickle cell disease. (cdc.gov)
  • The study by the Centers for Disease Control and Prevention (CDC), "Health Status and Healthcare Use in a National Sample of Children with Sickle Cell Disease," was published in the American Journal of Preventive Medicine. (cdc.gov)
  • The study found that black children with sickle cell disease are four times more likely to have fair or poor health status, twice as likely to have recently visited a mental health professional and have received special educational or early intervention services more often compared with black children without sickle cell disease. (cdc.gov)
  • Sickle cell disease is a group of red blood cell disorders that is inherited, passed from parents to children. (cdc.gov)
  • In sickle cell disease, the red blood cells become hard and sticky, and take on a sickle shape. (cdc.gov)
  • The findings of this study emphasize the importance of screening children with sickle cell disease for thinking ability, hearing, and vision problems. (cdc.gov)
  • This study gives a better insight into the types of disabilities children with sickle cell disease have and can help health care providers plan comprehensive treatments for children with the disease," said Dr. Boulet. (cdc.gov)
  • We demonstrated that mitochondrial calcium released by voltage-dependent anion channel 1 (VDAC1) after sciatic nerve injury triggers Schwann cell demyelination via ERK1/2, p38, JNK, and c-JUN activation. (jci.org)
  • The NLRP3 then processes the precursor pro-IL-1β into mature-IL-1β and triggers pro-inflammatory cell death termed pyroptosis 2 . (nature.com)
  • Subcellular fractionation and Western blot disclose that stimulation with LL-37 (8 μM) for 2 h triggers release of the mitochondrial protein apoptosis-inducing factor (AIF) to the cytosol, whereas LL-37 causes no release of cytochrome C oxidase subunit IV of the inner mitochondrial membrane, suggesting that LL-37 affects mitochondrial membrane. (lu.se)
  • We conclude that LL-37 is rapidly internalized by MG63 cells and accumulates in mitochondria, and that the peptide triggers release of pro-apoptotic AIF and directly affects mitochondrial membrane structural properties. (lu.se)
  • Our previous work showed that upon the alteration of the blood-retina barrier, the serine protease thrombin could contribute to the transformation, proliferation, and migration of RPE cells. (molvis.org)
  • Our findings pointed out that in seeded ePTFE grafts , anastomotic smooth muscle cell proliferation and intimal thickening could take place underneath an intact endothelium because seeded EC may release several growth factors . (bvsalud.org)
  • Breast cancer stem cells (BCSCs) play a critical role in tumor recurrence and metastasis. (nih.gov)
  • The updated guidelines detail best practices for conducting research with human embryonic stem cells. (biopharminternational.com)
  • The guidelines detail best practices for conducting research with human embryonic stem cells, and attempt to navigate some of the complex scientific and ethical issues that have arisen related to stem cell research. (biopharminternational.com)
  • ISSCR also writes induced pluripotent stem cells (iPS cells) should be excluded from specific stem cell research oversight. (biopharminternational.com)
  • Whether or not stem cell research lives up to the media hype has been a popular discussion among experts, some of which believe communicators have neglected to emphasize the challenges associated with using stem cells. (biopharminternational.com)
  • ISSCR advocates for robust safety precautions for clinical trials involving human embryonic stem cells. (biopharminternational.com)
  • Durham, NC (November 24, 2020) - A new treatment for atherosclerosis, commonly known as hardening of the arteries, may be on the horizon, according to a study released today in STEM CELLS Translational Medicine (SCTM) . (stemcellsportal.com)
  • MSCs are stem cells that can be isolated from bone marrow, adipose and other tissue sources. (stemcellsportal.com)
  • Durham, NC (October 27, 2020) - A study released today in STEM CELLS may point to a new treatment for myelin-related disorders including Charcot-Marie-Tooth (CMT) disease. (stemcellsportal.com)
  • Durham, NC (October 7, 2020) - A study released today in STEM CELLS Translational Medicine points the way to a possible new avenue of treatment for ischemic stroke. (stemcellsportal.com)
  • Three days after donation of peripheral blood stem cells to a recipient with acute myeloblastic leukemia, dengue virus was detected in the donor, who had recently traveled to Sri Lanka. (cdc.gov)
  • The team suspects apoptotic cells may also help drive the growth of metastatic tumors in humans. (cancer.gov)
  • 10 9 apoptotic events occurring per day in human adult tissues, it is surprisingly difficult to histologically detect apoptotic cells due to the rapid recognition and clearance of apoptotic cells. (nature.com)
  • In addition to maintenance of membrane integrity, apoptotic cells can be discriminated from viable counterparts based on several morphological hallmarks, including cell contraction, nuclear condensation and fragmentation, and actomyosin contraction-dependent membrane blebbing and apoptotic body formation. (nature.com)
  • Cell surface sensors on immune cells that ordinarily recognize pathogen-associated molecular patterns produced by infectious agents may also interact with DAMPs, leading to the activation of signaling pathways resulting in a nonpathogen-induced 'sterile' inflammatory response. (nature.com)
  • Immune cell responses induced by DAMPs may include cytokine and chemokine release to activate inflammatory cells such as neutrophils and macrophages. (nature.com)
  • No dose-limiting toxicities or immune effector cell-associated neurotoxicity were observed in any of the patients. (aacr.org)
  • We examined the role of neuroendocrine changes, particularly TRH and PRL, during the T cell-dependent immune response. (bris.ac.uk)
  • These studies demonstrate, for the first time, that the T cell-dependent immune response is critically dependent on the early activation of TRH and PRL and that the neuroendocrine changes occurring during it are profoundly different from those occurring during the T cell-independent and inflammatory responses (LPS model). (bris.ac.uk)
  • Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
  • The characteristics of this response would include production of neutralizing antibodies, generation of a T-cell response, and avoidance of immune-enhanced disease4. (who.int)
  • Thermo Fisher Scientific connects you with the technical expertise, regulatory guidance, and custom or off-the-shelf solutions you need to overcome obstacles, streamline processes and advance your cell and gene therapies. (brighttalk.com)
  • Although the therapies have shown promise, patients can relapse if mutated versions of the proteins-which can't be targeted by the T cells - become more prevalent in a tumor. (tgen.org)
  • The findings could help clinicians and patients choose from among a variety of T cell therapies for multiple myeloma to find treatments that best match a patient's available tumor targets. (tgen.org)
  • As more T cell therapies are approved that target these targets and others, results from whole genome sequencing will become crucial in determining which drug to use and in which order. (tgen.org)
  • Tenpoint is a biotechnology company committed to advancing engineered cell-based therapies and in vivo reprogramming to restore vision for people with degenerative ocular diseases, bringing together the global experts who are shaping the regenerative ocular medicine revolution and the technologies that are driving it. (businesswire.com)
  • We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
  • We identified 231 proteins released from actomyosin contraction-dependent blebs and apoptotic bodies by adapted SILAC (stable isotope labeling with amino acids in cell culture) combined with mass spectrometry analysis. (nature.com)
  • The most enriched proteins released were the nucleosomal histones, which have previously been identified as damage-associated molecular pattern proteins (DAMPs) that can initiate sterile inflammatory responses. (nature.com)
  • These results indicate that limited membrane permeabilization occurs in blebs and apoptotic bodies before secondary necrosis, leading to acute and localized release of immunomodulatory proteins during the early phase of active apoptotic membrane blebbing. (nature.com)
  • Among the newest types of treatments for multiple myeloma are T cell immunotherapies that target specific tumor proteins. (tgen.org)
  • Beat cells of the pancreas and neurons both have receptors for picking up neurotrophins - proteins that stimulate the development, maintenance and functions of neurons. (labroots.com)
  • In the present study, we examined potential contributory roles of membrane-associated, cholesterol-enriched lipid rafts/caveolae and their constituent proteins (e.g., caveolin-1 [Cav-1]) as potential sites for IL-1β−induced nitric oxide (NO) release in the isolated β-cell. (diabetesjournals.org)
  • Riding the momentum from the successful launch of the outdoor hydrogen fuel cell backup power solution, CommScope turns its focus indoors and now offers an innovative, compact indoor solution providing reliable backup power for enterprise data centers in North America. (mecojax.com)
  • Operating expense is another growing concern for data centers and, depending on the configuration, the indoor hydrogen fuel cell solution can bea lower cost solution than traditional power solutions after just two or three years. (mecojax.com)
  • CommScope will offer the indoor and outdoor hydrogen fuel cell backup power solution through its extensive PartnerPRO Network, which can assist customers with site planning, installation, commissioning and on-going maintenance of the backup power solution. (mecojax.com)
  • Finally, we successfully detected NO release in RAW 264.7 macrophages, using a planar-type xerogel-derived NO sensor. (intechopen.com)
  • 2 , 3 A key feature of apoptosis has been defined as the maintenance of an intact cellular membrane (detectable as exclusion of impermeable dyes such as propidium iodide, PI) throughout the apoptotic program to prevent intracellular protein release and subsequent immunological activation. (nature.com)
  • The intracellular domains ensure intracellular signaling necessary to activate the effector functions of the CAR T cell. (medscape.com)
  • When the C-shaped cells travel through small blood vessels, they clog the vessels and can block blood flow. (cdc.gov)
  • They learned that elevated blood glucose levels cause the release of NGF from pancreatic blood vessels. (labroots.com)
  • We investigated the PDGF-BB and bFGF release in vitro by umbilical vein EC seeded on precoated expanded polytetrafluoroethylene (ePTFE) prostheses . (bvsalud.org)
  • In diabetic mice, VDAC1 activity was altered, resulting in a mitochondrial calcium leak in Schwann cell cytoplasm, thereby priming the cell for demyelination. (jci.org)
  • Moreover, reduction of mitochondrial calcium release, either by shRNA-mediated VDAC1 silencing or pharmacological inhibition, prevented demyelination, leading to nerve conduction and neuromuscular performance recovery in rodent models of diabetic neuropathy and Charcot-Marie-Tooth diseases. (jci.org)
  • Mitochondrial reactive oxygen species (mtROS) driven by gefitinib stimulated the formation of the NLRP3 (NACHT, LRR and PYD-containing protein 3) inflammasome, leading to mature-IL-1β release. (nature.com)
  • The human antimicrobial peptide LL-37 permeabilizes the plasma membrane of host cells, but LL-37-induced direct effects on mitochondrial membrane permeability and function has not been reported. (lu.se)
  • The media of mitochondria treated with LL-37 (8 μM) for 2 h contained 50% more AIF and three times more cytochrome C than that of control mitochondria, showing that LL-37 promotes release of both AIF and cytochrome C. Moreover, in vesicles reflecting mitochondrial membrane lipid composition, LL-37 stimulates membrane permeabilization and release of tracer molecules. (lu.se)
  • Their potential, however, is hampered by the body's tendency to reject any "allogeneic" cells or tissue, which means that the cells come from a donor other than the patient. (stemcellsportal.com)
  • Here, we report transmission of DENV to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
  • Immunologic and confocal microscopic evidence also suggested a transient but significant stimulation of tyrosine phosphorylation of Cav-1 in β-cells briefly (for 15 min) exposed to IL-1β that was markedly attenuated by three structurally distinct inhibitors of protein tyrosine phosphorylation. (diabetesjournals.org)
  • Once infused, the cells continue to expand in number and bind to cancer cells via the engineered receptor, resulting in immunologic cancer cell death. (medscape.com)
  • are not responsible for the accuracy of news releases posted to EurekAlert! (eurekalert.org)
  • GSTO1 interacts with the ryanodine receptor RYR1 and promotes calcium release from the endoplasmic reticulum. (nih.gov)
  • The research team next plans to explore other areas of dopamine neuron activity that remain poorly understood, such as the dependence of dopamine release on calcium from outside the brain cells, says Rice, a professor in the Departments of Neurosurgery and Neuroscience and Physiology at NYU Langone. (scitechdaily.com)
  • This study showed for the first time that thrombin promotes specific, dose-dependent glutamate release from RPE cells, induced by the activation of protease-activated receptor 1 (PAR-1). (molvis.org)
  • Expression of ICAM-1, VCAM-1, and E-selectin was not altered following incubation with tryptase, but the potent granulocyte chemoattractant IL-8 was released in a dose-dependent fashion in response to physiologically relevant concentrations, with maximal levels in supernatants after 24 h. (eurekamag.com)
  • Colchicine (10 −8 M to 10 −4 M) inhibits insulin release in a dose-dependent manner. (diabetesjournals.org)
  • Schwann cells produce myelin sheath around peripheral nerve axons. (jci.org)
  • with mastocytosis, characterized by numerous hyperactive mast cells in most tissues, is 10-fold higher than the general population suggesting mast cell involvement. (tufts.edu)
  • We, therefore, investigated the effect of mercuric chloride (HgCl2) on human mast cell activation. (tufts.edu)
  • We have investigated the proinflammatory actions of the major mast cell product tryptase on HUVEC. (eurekamag.com)
  • there-after, GK mRNA expression, GK activity and insulin release were studied. (nih.gov)
  • Insulin release was not affected by biotin treatment. (nih.gov)
  • To study the mechanism of insulin release, we examined β-granule movement in the cytoplasm of monolayer-cultured B-cells. (diabetesjournals.org)
  • Granule movement also decreased when insulin release was inhibited by lowering glucose from 16.5 mM to 2.7 mM. (diabetesjournals.org)
  • Thus, granule movement participates in the mechanism of insulin release and may be related to the microtubular system. (diabetesjournals.org)
  • Therefore, the shift from apoptosis to secondary necrosis is more graded than a simple binary switch, with the membrane permeabilization of apoptotic bodies and consequent limited release of DAMPs contributing to the transition between these states. (nature.com)
  • Immunofluorescence Cells were prepared for fluorescence microscopy by permeabilization for 3 min with 0.1% Triton-X100 blocked with 5% BSA and. (exposed-skin-care.net)
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
  • ATCC is a premier global biological materials and information resource and standards organization and the leading developer and supplier of authenticated cell lines, microorganisms, and associated data for academia, industry, and government. (atcc.org)
  • Addition of purified tryptase was found to stimulate thymidine incorporation, but induced little alteration in cell numbers, suggesting it is not a growth factor for HUVEC. (eurekamag.com)
  • However, tryptase was a more selective stimulus than TNF-alpha and did not induce increased expression of mRNA for granulocyte-macrophage CSF or stimulate the release of this cytokine. (eurekamag.com)
  • Median progression-free and overall survival were not reached at the time of follow-up, and all responding patients continued to have CAR T-cell persistence at the time of data cutoff. (aacr.org)
  • [ 4 ] Persistence of CAR T cells for as long as 3 years has been reported. (medscape.com)
  • which means both copies of the gene in each cell have mutations. (medlineplus.gov)
  • New data in the Allen Brain Observatory captures the activity of nearly 30,000 mouse brain cells in the visual cortex, the part of the brain that processes visual information. (alleninstitute.org)
  • The Allen Cell Types Database team also added data from more than 30,000 different brain cells. (alleninstitute.org)
  • Similar to the Iranian government, which released 73,000 inmates , the Indonesian government plans to release at least 30,000 detainees to prevent the spread of coronavirus in the country's overcrowded jails. (medicalxpress.com)
  • it recognizes a specific protein on the surface of malignant cells (eg, CD19 on B-cells). (medscape.com)
  • Exposure of breast cancer cells to chemotherapy leads to an enrichment of BCSCs. (nih.gov)
  • Host cells detect the presence of bacteria using a receptor called TLR9, which senses bacterial DNA (1). (the-scientist.com)
  • The study demonstrates how injecting mice with early outgrowth cells (EOCs), after first treating the cells with chemicals to activate a type of protein called liver x receptor (LXR), slows the development of this disease. (stemcellsportal.com)
  • Prolia works by blocking a protein called RANK (receptor activator of nuclear factor kappa beta) and helps prevent bone cells called osteoclasts from breaking down bone in the body. (medlineplus.gov)
  • The release nearly doubles the number of cells observed to date, bringing the total to more than 63,000 brain cells from 13 different types of excitatory and inhibitory nerve cells. (alleninstitute.org)
  • Release of the proinflammatory cytokines IL-6, IL-8, and TNF-a was measured and PKC isoform activities assessed. (cdc.gov)
  • You'll learn about regulatory requirements for GMP ancillary materials for cell and gene therapy, closed-system manufacturing and how it can improve overall productivity and product safety, and characterization and lot release testing, proper validation for regulatory CMC filing. (brighttalk.com)
  • The new lab also ideally extends the existing competencies of FEV's battery cell test benches in Munich and France, which are focused on electrical cell characterization. (fev.com)
  • Here, we provide evidence that gefitinib elicits pro-inflammatory responses by promoting mature-interleukin-1β (IL-1β) and high-mobility group box 1 (HMGB1) release. (nature.com)
  • These data suggest that biotin may influence glucose metabolism also by acting directly at the level of beta-cells. (nih.gov)
  • This project was sparked by seeing NGF receptors present in beta-cells,' said Kuruvilla. (labroots.com)
  • Mast cells are involved in allergic reactions, but also in innate and acquired immunity, as well as in inflammation. (tufts.edu)
  • A case-control study was conducted to cells from asthmatic patients generate more compare the vitamin C status of asthmatics reactive oxygen species than those from and healthy people at Massih Daneshvari controls. (who.int)