AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Cell DegranulationMast Cellsp-Methoxy-N-methylphenethylamineHistamine ReleaseReceptors, IgEImmunoglobulin EAnaphylaxisPassive Cutaneous AnaphylaxisCromolyn Sodiumbeta-N-AcetylhexosaminidasesTryptasesCytoplasmic GranulesHistamineChymasesKetotifenBasophilsAnti-Allergic AgentsMastocytosisNorbornanesComplement C3aBasophil Degranulation TestHypersensitivitySkinEdemaCells, CulturedHistamine AntagonistsAllergensNeutrophilsEosinophilsMice, Inbred C57BLSerine EndopeptidasesPeritoneal CavityUrticariaGliotoxinSubstance PCapillary PermeabilityPyrilamineConjunctivitis, AllergicOvalbuminCell CountExocytosisVenulesReceptors, Prostaglandin E, EP1 SubtypeMice, KnockoutCalciumStreptomycetaceaeMice, Inbred BALB CBone Marrow CellsAntigensReceptors, Prostaglandin E, EP3 SubtypePhospholipase C gammaProto-Oncogene Proteins c-kitSignal TransductionDermatitisMethysergideLeukemia, Basophilic, AcuteCytokinesMice, Mutant StrainsStem Cell FactorHypersensitivity, ImmediateReceptor, PAR-2Disease Models, AnimalCell LineRats, WistarReceptors, IgGMastocytosis, SystemicReaginsLungRats, Inbred BNLeukemia, Mast-CellReceptors, NeurotensinNeutrophil InfiltrationInflammationEosinophil PeroxidaseCarboxypeptidases AInflammation MediatorsPhosphorylationSerotoninThioxanthenesSerine Proteinase InhibitorsTime FactorsSplanchnic CirculationBronchial HyperreactivityLysosomal-Associated Membrane Protein 1Rats, Sprague-DawleyN-Formylmethionine Leucyl-PhenylalanineLeukocytesAsthmaAntigens, CD63Receptors, Prostaglandin E, EP2 SubtypeInterleukin-4Dose-Response Relationship, DrugCalcium SignalingFlow CytometryGuinea PigsKiller Cells, NaturalIntestinal MucosaCell AdhesionLeukotriene C4Protein-Tyrosine Kinases
BasophilsHistamine releaseMediatorsInflammationGranulesEosinophilsPiecemeal degranulationAnaphylaxisPeritoneal mastLysisSurface of mast cellsDendritic cellsRole of mast cellsAntibodiesMurineSignaling pathwayMucosalCorticotropin-ReleasiReceptorsSecretionHypersensitivityReleaseCutaneousAllergensTissueInfiltrationPlasma membraneMastocytosisExtractMacrophagesImmunoglobulinNoxiousExposureResponsesGranuleMechanismActivationTryptaseMiceNeuronsMoleculesProteinDependentPhenotypeVascularAntihistaminesMesenchymal stemBone marrowAsthmaSecretePeripheralMarkerMyeloidCytokinesInflammatory cellsSolubleCompoundTissuesTriggerImmune cells
Basophils8
Histamine release4
Mediators10
  • These results suggest that in diabetic mice undergoing polymicrobial infection, mast cells play a key role in the neutrophil migration failure due to reduction of the CXCR2 expression, resulting in bacterial spreading and systemic release of mediators, and as a consequence augmented susceptibility to sepsis development. (biomedcentral.com)
  • Recent evidence indicates that RFamides act as mediators in mast cell-sensory nerve communications related to allergic disease. (uantwerpen.be)
  • Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)
  • Further exposures result in the bridging of 2 adjacent IgE molecules, leading to the release of preformed mediators from mast cell granules. (medscape.com)
  • Mediators released by these cells prolong the earlier reactions and lead to chronic inflammation. (medscape.com)
  • Inhibition of release of inflammatory mediators in rat peritoneal mast cells and murine macrophages by a Chinese herbal medicine formula (RCM-102). (wikidata.org)
  • This results in mast cell degranulation and release of histamine and other inflammatory mediators. (onteenstoday.com)
  • The activation of these cells leads to the release of chemical mediators such as histamine and arachidonic acid metabolites, which increase vascular permeability and tissue swelling 9 . (bvsalud.org)
  • The safety of higher-dose antihistamines (beyond the level of US Food and Drug Administration approval) has not been studied in pregnancy, and because mast cells mediators, including histamine, participate in uterine adaptation, there is reason for caution. (medscape.com)
  • Physicians treating mast cell diseases in pregnancy should remember that mast cells and their mediators are clinically relevant not only in disease, but also in the uterus of the healthy patient. (medscape.com)
Inflammation17
  • Previous work by our group has shown that the expression levels of some members of the Mas-related gene receptor (Mrgpr) family in both enteric neurons and mucosal mast cells change during intestinal inflammation. (uantwerpen.be)
  • Ehrlich's discovery of mast cells was a significant contribution to the understanding of the immune system and its role in allergic reactions and inflammation. (proprofs.com)
  • When mast cells are activated, they release cytokines such as histamine, interleukins, and tumor necrosis factor, which can trigger various immune responses and contribute to allergic reactions and inflammation. (proprofs.com)
  • 1% TF extract with 0.1% HC inhibited skin inflammation through decrease in inflammatory cells infiltration as well as inhibition of Orai-1 expression in skin tissues. (hindawi.com)
  • The present study demonstrates that the topical application of TF extract improves skin inflammation in AD mice, and the mechanism for this effect appears to be related to the modulation of calcium channels and mast cell activation. (hindawi.com)
  • In this study, we investigated the effects of TF extract on skin inflammation in an AD animal model and also investigated the mechanism responsible for the effects of TF extract in AD on the modulation of calcium channels and the activation of mast cells. (hindawi.com)
  • This agent decreases inflammation by stabilizing lysosomal membranes, inhibiting polymorphonuclear leukocyte and mast cell degranulation. (medscape.com)
  • Reduces itching and inflammation by suppressing release of cytokines from T cells. (medscape.com)
  • In type 1 asthma, the Ig-E bind to mast cells, resulting in the release of histamines and leukotrienes leading to inflammation of eosinophils, which is a hallmark of allergic inflammatory response and a degranulation process. (bdbiosciences.com)
  • Ig-E-mediated food allergy involves the binding of food allergens to Ig-E molecules leading to the activation of effector cells releasing histamine (immediate response) followed by allergic inflammation with increased leukotrienes, platelet activating factor (PAF), and IL-4, IL-5 and IL-13 cytokines. (bdbiosciences.com)
  • White blood cells are immune system cells having responsibility to control inflammation, fight infection, clean up the breakdown products of day-to-day cellular function, and more. (thehonestkitchen.com)
  • Our aims were to prove that crowding stress induces mucosal inflammation and intestinal dysfunction, to characterize dynamics in time, and to evaluate the implication of stress-induced mast cell activation on intestinal dysfunction. (nih.gov)
  • Stress-induced intestinal chrono-pathobiology was determined by measuring intestinal inflammation, epithelial damage, mast cell activation and infiltration, and intestinal barrier function. (nih.gov)
  • Taken together, we have provided evidences that long-term exposure to psychosocial stress promotes mucosal inflammation and mast cell-mediated barrier dysfunction in the rat bowel. (nih.gov)
  • Melittin triggers the synthesis of the cortisol hormone that suppresses inflammation and increases the resistance of cell walls. (fountainmagazine.com)
  • G-Rh2 inhibits mast cell -induced allergic inflammation , which might be mediated by the AKT-Nrf2/NF-κB and p38MAPK-Nrf2/NF-κB signaling pathways. (bvsalud.org)
  • Mast cells play an important role in a variety of biological processes including allergic reactions, atherosclerosis and inflammation 7,8 . (bvsalud.org)
Granules11
  • He observed and described a type of cell with granules in their cytoplasm, which he named "mastzellen" or mast cells. (proprofs.com)
  • The granules of mast cells are rich in which of the following compounds? (proprofs.com)
  • Mast cells contain granules that are rich in histamine. (proprofs.com)
  • Mast cells are a type of white blood cell localized in most tissues of the body that fight off parasitic infections by releasing histamine and other inflammatory factors contained in secretory granules. (sciencedaily.com)
  • When mast cells are activated by allergens bound to immunoglobulin E antibodies, secretory granules move along microtubules to the periphery of the cells, where they can fuse with the plasma membrane and release their contents. (sciencedaily.com)
  • Their mast cells showed lower levels of secretory granule release because the granules were no longer transported to the plasma membrane upon mast cell activation. (sciencedaily.com)
  • The researchers discovered that, in response to mast cell stimulation, a signaling pathway involving the enzyme phosphatidylinositol 3-kinase triggers kinesin-1's association with a protein complex on the surface of secretory granules. (sciencedaily.com)
  • Mast cells are filled with granules, which are sack-like pockets of biochemicals that help protect the body from invading pathogens (parasites, etc.) and antigens (immune system stimulating substances, like pollen, etc. (thehonestkitchen.com)
  • Instead of their primary role protecting the body from the effects of parasites, mast cells are stimulated to release their granules after encountering common substances in our environment, like pollen, which leads to an allergic response. (thehonestkitchen.com)
  • When mast cells release their granules, a variety of physiologic changes take place. (thehonestkitchen.com)
  • [ 8 ] As such, tryptase is specific to mast cell granules and can provide information about mast cell number, distribution, and activation depending on the clinical context. (medscape.com)
Eosinophils1
  • In nasal cytologic studies, the presence of eosinophils and goblet cells is generally suggestive of allergy, whereas the presence of neutrophils and bacteria is characteristic of infection. (medscape.com)
Piecemeal degranulation3
  • Neuropeptide AF induces piecemeal degranulation in murine mucosal mast cells : a new mediator in neuro-immune communication in the intestinal lamina propria? (uantwerpen.be)
  • BMMCs were found to express MrgprA4 and A1, and functional analysis of the effects of NPAF by means of a beta-hexosaminidase assay, mMCP-1 ELISA, electron microscopy and live cell calcium imaging revealed a piecemeal degranulation induced by NPAF. (uantwerpen.be)
  • While mast cell counts remained mostly unchanged, piecemeal degranulation increased along time, as the mucosal content and luminal release of rat mast cell protease-II. (nih.gov)
Anaphylaxis7
  • The study, "Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex," which will be published online October 24 ahead of issue in The Journal of Cell Biology , suggests that targeting this motor may be a new way to treat patients undergoing anaphylactic shock. (sciencedaily.com)
  • The fact that mice lacking Kif5b in their mast cells exhibited very low levels of passive, systemic anaphylaxis suggests that kinesin-1 could be a valuable new therapeutic target for controlling allergic reactions," Ménasché says. (sciencedaily.com)
  • Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-κB and MAPK-Nrf2/NF-κB pathways. (bvsalud.org)
  • The effect of ginsenoside Rh2 (G-Rh2) on mast cell -mediated anaphylaxis remains unclear. (bvsalud.org)
  • Herein, we investigated the effects of G-Rh2 on OVA -induced asthmatic mice and on mast cell -mediated anaphylaxis . (bvsalud.org)
  • Tryptase levels of 11.5 ng/mL or greater are indicative of either mast cell activation (as in anaphylaxis) or increased total mast cell levels (as in mastocytosis). (medscape.com)
  • Other than anaphylaxis, however, it is not clear what other manifestations of mast cell disorders post a risk for the fetus. (medscape.com)
Peritoneal mast3
  • Concanavalin A (Con A) covalently linked to Sepharose 4B beads induced localized degranulation of sensitized rat peritoneal mast cells in regions of contact between beads and cells. (rupress.org)
  • Intestinal and Peritoneal Mast Cells Differ in Kinetics of Quantal Release. (us.es)
  • Meeting-Abstract: Exo-Endocytosis in Response to Stress Hormonal Stimulation in Peritoneal Mast Cells. (us.es)
Lysis1
Surface of mast cells1
Dendritic cells3
  • The establishment of oral tolerance is dependent on the controlled uptake of food proteins through the intestinal epithelial barrier and its delivery to local dendritic cells (DC) that matured in the intestinal pro-tolerogenic environment. (frontiersin.org)
  • Skin-resident dendritic cells act as a first line of defense, ingesting foreign substances, processing them, and presenting them to lymphocytes to activate the immune system. (ernolaszlo.com)
  • Different populations of immune cells are engaged in an allergic reaction, including antigen presenting cells (e.g., dendritic cells), mast cells and Ig-E producing B cells and T cells. (bdbiosciences.com)
Role of mast cells2
  • The role of mast cells in the inflammatory dental pulp response is not clear. (bvsalud.org)
  • The authors discuss the role of mast cells in pregnancy in both healthy and disease states in a review article published in May. (medscape.com)
Antibodies1
Murine1
  • Here, we use a murine model in which the E7 protein of HPV16 is expressed as a transgene in epithelium to show that mast cells are recruited to the basal layer of E7-expressing epithelium, and that this recruitment is dependent on the epithelial hyperproliferation induced by E7 by inactivating Rb dependent cell cycle regulation. (figshare.com)
Signaling pathway2
  • Interestingly, G-Rh2 was involved in the FcεRI pathway activation of mast cells and the transduction of the Lyn/Syk signaling pathway. (bvsalud.org)
  • Meanwhile, G-Rh2 reduced the levels of p-AKT, p38MAPK and Nrf2 in RBL-2H3 sensitized IgE cells and inhibited NF-κB signaling pathway activation by activating the AKT-Nrf2 and p38MAPK-Nrf2 pathways. (bvsalud.org)
Mucosal2
  • To this end, the expression and distribution patterns of NPFF/AF receptors and the NPFF precursor protein were determined in bone marrow-derived mucosal mast cells (BMMCs) by immunocytochemistry and (RT-) PCR. (uantwerpen.be)
  • Specific Treg then provide active tolerance to the harmless food proteins at all mucosal surfaces, either via cell contact or via their secretion of immunosuppressive factors that both prevent the induction of adaptive T helper (Th) lymphocytes in response to antigenic re-exposure ( 7 ). (frontiersin.org)
Corticotropin-Releasi1
  • Identification of a New Exo-Endocytic Mechanism Triggered by Corticotropin-Releasing Hormone in Mast Cells. (us.es)
Receptors13
  • The finding that sensitized mast cells which had adhered to Con A-Sepharose beads degranulated in regions of the cell away from the area of bead contact if exposed to soluble Con A excluded the possibility that the localized release was due to a redistribution of the IgE receptors or putative Ca2+ channels to the region of bead contact. (rupress.org)
  • The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. (wikipedia.org)
  • Fc binds to various cell receptors and complement proteins. (wikipedia.org)
  • The aim of the present study was to investigate whether RFamides of the NPFF group are expressed in the gastrointestinal tract and to identify possible targets and receptors that might be involved in RFamide-associated mast cell modulation. (uantwerpen.be)
  • The full spectrum act by cross-linking HLA-DR or DQ molecules and T-cell of clinical signs and symptoms of intoxication with SEB is receptors. (cdc.gov)
  • Different fragments, released from individual components during complement activation, operate by a non-cytolytic mechanism through specific receptors present on various cell types. (dadamo.com)
  • The direction and intensity of the biological response depend on the state of the receptors (affinity and density) and on the function of cells bearing receptors. (dadamo.com)
  • Adherent receptors mediate adherence of cells and other particles with bound C3b or C4b fragments and are known as CR1 to CR5. (dadamo.com)
  • These receptors, present on the other cells of the immune system, are involved in a variety of immunoregulatory reactions. (dadamo.com)
  • Furthermore, mast cells and H1 receptors have not been the primary sites of antipruritic action of this extract. (researchgate.net)
  • 14 - 18 Two principal cannabinoid receptors have been described (CB1, which is predominant in neurons, and CB2, which is localized in immune cells and peripheral tissue cells). (arvojournals.org)
  • Histamine is the ligand for 2 membrane-bound receptors, the H1 and H2 receptors, which are present on many cell types. (medscape.com)
  • The activation of the H1 histamine receptors on endothelial and smooth muscle cells leads to increased capillary permeability. (medscape.com)
Secretion3
  • One member of this complex, Rab27b, has previously been shown to regulate mast cell secretion. (sciencedaily.com)
  • E7 induced epithelial hyperplasia is associated with increased epidermal secretion of CCL2 and CCL5 chemokines, which attract mast cells to the skin. (figshare.com)
  • Moreover, the ABE-EtOAc subfractions suppressed the secretion of interleukin (IL)-4, IL-6 and tumor necrosis factor-α in the RBL-2H3 cells, indicating that adlay bran can inhibit cytokine secretion in the late phase of the allergic reaction. (greenmedinfo.com)
Hypersensitivity4
Release6
  • When mast cells are activated, they release histamine, which causes blood vessels to dilate, smooth muscles to contract, and an increase in mucus production. (proprofs.com)
  • TF extract decreased β -hexosaminidase release in RBL-2H3 cells. (hindawi.com)
  • But allergens can also trigger granule release, and, if this happens simultaneously in mast cells throughout the body, it can provoke a life-threatening anaphylactic response that leads to facial swelling, difficulty breathing, a drop in blood pressure, and fainting. (sciencedaily.com)
  • A study showed that ganoderic acids C and D isolated from G. lucidum inhibit the release of histamine from mast cells [81] . (researchgate.net)
  • ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells. (greenmedinfo.com)
  • Yet later, mast cells have the potential to disrupt pregnancy, because mast cell-mediator release is associated with preterm delivery. (medscape.com)
Cutaneous1
Allergens2
  • These cells play a crucial role in the immune system by releasing inflammatory substances, such as histamine, in response to allergens or pathogens. (proprofs.com)
  • This process is called degranulation and can be a normal response to environmental allergens or as an allergic response to a chemical stimulant (bee/insect venom, etc. (thehonestkitchen.com)
Tissue3
  • The STAT3 protein is also involved in the formation of cells that build and break down bone tissue, which could help explain why STAT3 gene mutations lead to the skeletal and dental abnormalities characteristic of this condition. (medlineplus.gov)
  • Melittin also triggers the immune system cells that prevent the formation of free radicals, which normally damage cells and tissue. (fountainmagazine.com)
  • In early pregnancy, mast cells modulate "tissue remodeling, angiogenesis and spiral artery modifications. (medscape.com)
Infiltration1
  • On histopathology, this fibroinflammatory disease is characterized with specific findings such as lymphoplasmacytic infiltration of IgG4-positive plasma cells, obliterative phlebitis, and storiform fibrosis, in most cases accompanied by increased levels of serum IgG4 [ 10 ]. (hindawi.com)
Plasma membrane1
  • The results suggest that, if an influx of Ca2+ is the mechanism for initiating mast cell degranulation, then the opening of Ca2+ channels in the plasma membrane of activated mast cells is a localized event and that Ca2+ acts locally within the cell to initiate exocytosis. (rupress.org)
Mastocytosis1
  • The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of "mast cell activation syndrome" (MCAS) grown significantly. (degruyter.com)
Extract4
  • TF extract inhibited Orai-1 activity in Orai-1-STIM1 cooverexpressing HEK293T cells but increased TRPV3 activity in TRPV3-overexpressing HEK293T cells. (hindawi.com)
  • and 4) mast cell degranulation by HW extract was tested, using rat mesentery and canine cultured mast cells. (avma.org)
  • experiment 4: HW extract degranulated rat mesentery mast cells and released histamine directly from canine mast cells. (avma.org)
  • Conclusions and Clinical Relevance -Results of our study indicate that an unknown mast cell-degranulating substances contained in HW extract may degranulate mast cells directly, consequently releasing histamine that may participate in the onset of shock in HW extract-induced shock in dogs. (avma.org)
Macrophages2
  • After initial exposure to an antigen, antigen-processing cells (macrophages) present the processed peptides to T helper cells. (medscape.com)
  • however, significant amounts are also produced by monocytes, macrophages, and epithelial cells in the gastrointestinal and genitourinary tracts. (dadamo.com)
Immunoglobulin2
  • The B cells may further differentiate into plasma cells and produce immunoglobulin E (IgE) specific to that antigen. (medscape.com)
  • Alternate pathway activation occurs when components of microbial cell surfaces (eg, yeast walls, bacterial cell wall lipopolysaccharide [endotoxin]) or immunoglobulin (eg, nephritic factor, aggregated IgA) cleave small amounts of C3. (msdmanuals.com)
Noxious1
  • Over months to years of life the body's cells are exposed to a variety of noxious agents that cause cellular DNA changes ultimately manifesting as cancer. (thehonestkitchen.com)
Exposure2
  • Therefore, symptoms of mild exposure are anticipated to itary practitioners, since SEB has been previously resemble T-cell-mediated recall responses, similar to a developed as an incapacitating biowarfare agent. (cdc.gov)
  • Upon subsequent exposure to the same antigen, these cells are stimulated to differentiate into either more T helper cells or B cells. (medscape.com)
Responses3
  • In the late 1800s, Ehrlich conducted extensive research on cells involved in immune responses. (proprofs.com)
  • The classic wheal-and-flare responses result from the interaction between the antigen and sensitized mast cells in the skin. (medscape.com)
  • Since mast cells are active during inflammatory responses it becomes crucial to find out if these cells are actually present and play a role in dental pulp under normal and inflammatory conditions either in humans or in rats. (bvsalud.org)
Granule1
  • Of the four isoenzymes, beta tryptase is the predominant form stored in the mast cell granule where it is complexed as a tetramer stabilized by proteoglycans namely heparin. (medscape.com)
Mechanism2
  • The complement system influence the activity of numerous cells, tissues and physiological mechanism of the body. (dadamo.com)
  • 15 , 20 - 22 In vivo, AEA has a short duration of action: it is transported to cells by a carrier-mediated uptake mechanism, and it is hydrolyzed by the enzyme fatty acid amide hydrolase (FAAH). (arvojournals.org)
Activation7
  • AD has a complex etiology that involves activation of multiple immunological and inflammatory pathways along with disruption of epidermal barriers, elevated IgE levels, peripheral eosinophilia, and a predominance of Th2 cells expressing IL-4, IL-5, and IL-13 [ 2 ]. (hindawi.com)
  • It also inhibits transcription for genes that encode interleukin (IL)-3, IL-4, IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor-alpha, all of which are involved in early stages of T-cell activation. (medscape.com)
  • Urinary 9α,11β-PGF2 is presumably related to mast-cell activation 12 . (ersjournals.com)
  • Subsequent literature regarding this newly recognized (but of course not truly new) "mast cell activation syndrome" (MCAS) included case reports as well as formal studies (mostly relatively small scale), reviews, and various proposals for formal diagnostic criteria. (degruyter.com)
  • Stress-induced mitochondrial injury and increased jejunal permeability, both events strongly correlated with mast cell activation at day 15. (nih.gov)
  • Nuclear efflux of heterogeneous nuclear ribonucleoprotein C1/C2 in apoptotic cells: a novel nuclear export dependent on Rho-associated kinase activation. (ntu.edu.tw)
  • As such, determinations of tryptase levels are contingent on both the size and activation status of an individual's mast cell population but is not informative of the specific contribution of either of these factors. (medscape.com)
Tryptase1
  • In the pregnant uterus, mast cell numbers increase in the myometrium and shift from both tryptase and chymase mast cells to the tryptase-only phenotype. (medscape.com)
Mice3
  • In the present study we investigated the effect of the mast cell degranulation in neutrophil migration failure observed in diabetic mice after polymicrobial sepsis induced by cecal ligation and puncture (CLP). (biomedcentral.com)
  • The researchers created mice whose mast cells lacked a key subunit of kinesin-1 called Kif5b. (sciencedaily.com)
  • G-Rh2 inhibited OVA -induced airway remodeling , the production of TNF-α, IL-4 , IL-8 , IL-1 ß and the degranulation of mast cells of asthmatic mice . (bvsalud.org)
Neurons2
  • ProNPFF was expressed in neurons and BMMCs, suggesting that both cell types are potential sources of NPAF in situ. (uantwerpen.be)
  • Proteoglycans involved in bidirectional communication between mast cells and hippocampal neurons. (us.es)
Molecules1
  • Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
Protein8
  • Cell-fate-determinant molecule NUMB-interacting protein (TBC1D15) is overexpressed and contributes to p53 degradation in TICs. (nature.com)
  • The "pro-tolerogenic" antigen-loaded DC will migrate to draining mesenteric lymph nodes, where they will present the food protein-derived peptides to naive T cells and favour the induction of a subpopulation of T cells, namely regulatory T cells (Treg). (frontiersin.org)
  • In the immune system, the STAT3 protein regulates genes that are involved in the maturation of immune system cells, especially certain types of T cells . (medlineplus.gov)
  • In food protein-induced ailments such as food protein-induced enterocolitis syndrome (FPIES), food protein-induced proctocolitis (FPIP) and food protein enteropathy (FPE), allergen-specific T cells have been described. (bdbiosciences.com)
  • Thus, our findings suggest that mast cells, recruited towards CCL2 and CCL5 expressed by epithelium induced to proliferate by E7, may contribute to an immunosuppressive environment that enables the persistence of HPV E7 protein induced pre-cancerous lesions. (figshare.com)
  • Overexpression of neuronal intermediate filament protein internexin in PC 12 cells. (ntu.edu.tw)
  • Magnolol induces the distribvutional changes of p160 and adipose differentiation-related protein in adrenal cells. (ntu.edu.tw)
  • it occurs when mannose-binding lectin (MBL), a serum protein, binds to mannose, fucose, or N -acetylglucosamine groups on bacterial cell walls, yeast walls, or viruses. (msdmanuals.com)
Dependent1
  • This degranulation was Ca2+ dependent and was not seen when sensitized mast cells bound to beads conjugated with a nonstimulating lectin, wheat germ agglutinin, or when unsensitized mast cells bound to Con A-Sepharose. (rupress.org)
Phenotype1
  • Mast Cell Changes the Phenotype of Microglia via Histamine and ATP. (us.es)
Vascular1
  • Intravenously administered adenosine is rapidly cleared from the circulation via cellular uptake, primarily by erythrocytes and vascular endothelial cells. (nih.gov)
Antihistamines1
  • One type of urticaria in pregnancy-pruritic urticaria papules and plaques of pregnancy-has not yet clearly been linked to mast cells, but antihistamines are effective in this condition. (medscape.com)
Mesenchymal stem1
  • Highly efficient cellular labeling of mesoporous nanoparticles in human mesenchymal stem cells: implication for stem cell tracking. (ntu.edu.tw)
Bone marrow2
  • Pluripotent stem cells are found in the bone marrow and can give rise to different blood cell lineages including mast cells. (proprofs.com)
  • The liver, spleen, bone marrow, and lymph nodes are organs where white blood cells are produced and stored. (thehonestkitchen.com)
Asthma1
  • As with asthma, hormonal changes of pregnancy have an unpredictable influence on the underlying mast cell condition. (medscape.com)
Secrete2
  • Mast cells secrete histamine which increases sensory nerve excitability. (cdc.gov)
  • At the same time, dermicidin and antibacterial substances in sebum kill bacteria directly, and skin cells also secrete natural antibiotics, the defensins, that perforate and kill bacteria. (ernolaszlo.com)
Peripheral1
  • The aim of our research was to determine how immunotherapy changes the proportion of lymphocyte subsets in dog peripheral blood and the levels of cytokines secreted by these cells during therapy. (mdpi.com)
Marker1
  • Eosinophil-derived neurotoxin (EDN) is used as an eosinophil degranulation marker in urine. (ersjournals.com)
Myeloid1
  • A mast cell is a type of granulocyte which is derived from myeloid stem cells. (proprofs.com)
Cytokines2
Inflammatory cells1
  • Late-phase reactions begin 2-4 hours later and are caused by newly arrived inflammatory cells. (medscape.com)
Soluble1
  • The complement system consists of more than 35 soluble and cell-bound proteins, 12 of which are directly involved in the complement pathways. (dadamo.com)
Compound1
  • Compound 48/80-induced degranulation of GnRH-like immunoreactive mast cells in the brain and mesentry of the gerbil. (ntu.edu.tw)
Tissues4
  • Mast cells are numerous and widely distributed throughout the skin and the connective tissues that support arteries, veins, nerves, skeletal muscles and tendons in the tail. (cdc.gov)
  • Besides being in tissues, most white blood cells circulate throughout the body in the lymphatic system and blood vessels. (thehonestkitchen.com)
  • Mast cells are some of the body's first-line defenders and are mainly found imbedded in tissues and organs. (thehonestkitchen.com)
  • In this investigation we sought to answer the question concerning the presence of mast cells in human and rat dental pulp tissues, under normal and inflammatory conditions. (bvsalud.org)
Trigger1
Immune cells2
  • There were also significant differences in microbial composition in dust samples and in innate immune cells between the two groups of children. (medscape.com)
  • A shortage of functional STAT3 blocks the maturation of T cells (specifically a subset known as Th17 cells) and other immune cells. (medlineplus.gov)