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  • tumor
  • The presentation of a patient with multiple myeloma will depend on the type of neoplastic cell, type of immunoglobulin produced, location of the tumor, and severity of growth and infiltration. (animalmedcenter.com)
  • To attack tumor cells and viruses, CD-4 cells coordinate the overall immune response and help activate CD8 T-lymphocytes. (wikipedia.org)
  • Conversely, by facilitating the entry of killer lymphocytes into tumor cells, HEVs may have a beneficial effect in cancer. (healthcanal.com)
  • The aim of the study is to analyse at different stages of the disease, tumor samples and to characterise the cellular infiltrate in situ ( in particular T lymphocytes, NK cells and macrophages), the role of inhibitor receptors on in situ immunosuppression, and potential modulation by medical treatments such as dacarbazine. (clinicaltrials.gov)
  • A possible consequence of an antilymphocytic autoimmune process would be serious impairment of an animal's ability to destroy tumor cells. (rupress.org)
  • One measure of autoimmune reactivity of this type would be the demonstration of cellular immune responsiveness by cells from tumor-bearing mice against syngeneic normal cells. (rupress.org)
  • Dendritic cells are receiving increasing scientific and clinical interest due to their key role in the immune response and potential use with tumor vaccines. (chemocare.com)
  • This is done in the hope of stimulating the cells of the immune system to act more effectively or to make the tumor cells more recognizable to the immune system. (chemocare.com)
  • PBMC
  • However, our most recent laboratory data with unprimed PBMC has shown effective cell kill activity without the addition of G-CSF. (clinicaltrials.gov)
  • Using scintigraphic imaging including planar scintigraphy and SPECT, this study will evaluate the utility of two different ex vivo 99mTc-HMPAO labelled mononuclear cell populations in order to select the optimal methodology (using PBMC or purified lymphocyte subpopulations) for future drug intervention studies in Crohn's disease. (clinicaltrials.gov)
  • In the first, whole blood will be fractionated on a ficoll gradient to purify a heterogeneous population of all the peripheral blood mononuclear cells (PBMC) for labelling. (clinicaltrials.gov)
  • Secondly, further enrichment will be attempted using depletion of PBMC fractions of monocytes and B cells. (clinicaltrials.gov)
  • Variability and reproducibility of the PBMC and lymphocyte imaging methodologies at visits 1 and 2. (clinicaltrials.gov)
  • intracellular
  • This leads to an intracellular pathway that up-regulates more antigen-specific TCRs on the T cell and leads to effector functions. (statpearls.com)
  • Once an activated CD8+ migrates into circulation and finds its antigenic target (expressed on a virally infected cell or cell with intracellular bacteria, for example), it utilizes its killing function. (statpearls.com)
  • Activated CD8+ T cells express FasL which binds to Fas (CD95), a receptor found on many cell types, leading to the activation of caspases and subsequent apoptosis of the target cell (often a cell infected with intracellular bacteria, such as Listeria species or a virally infected cell). (statpearls.com)
  • antibody
  • Additionally, TLR subsets are expressed in B lymphocytes where they have intrinsic activities which include the promotion of antibody production and maintenance of long term memory. (grantome.com)
  • This proposal aims to understand the function of this receptor in regulating B cell responses leading to antibody production. (grantome.com)
  • B lymphocytes (or B cells) are each programmed to make one specific antibody. (chemocare.com)
  • Each plasma cell is essentially a factory for producing antibody. (chemocare.com)
  • Lymphoid
  • Lymphoid follicles in COPD patients have increased T-regulatory cells. (ersjournals.com)
  • The recent discovery of human innate lymphoid cells capable of rapidly producing large amounts of cytokines upon activation and the mouse data pointing to an essential role for these cells in asthma models have emphasized the important role of the innate immune system in asthma and have provided a new means of better understanding asthma mechanisms and differentiating its phenotypes. (docplayer.net)
  • Innate lymphoid cells (ILCs) are the newest described elements of the innate immune system and have received much attention over the last few years . (docplayer.net)
  • This group includes lymphoid tissue inducer (LTi) cells that promote the formation of lymph nodes . (docplayer.net)
  • proliferation
  • 3 - Lymph nodes support the proliferation and differentiation of immune cells. (healthcanal.com)
  • We diagnosed a new case of a clonal T-LGL proliferation in a 6-year-old girl presenting with severe neutropenia and pure red blood cell aplasia (PRCA). (kuleuven.be)
  • Barrier cells are recently recognized fibroblastic contractile stromal cells that fuse to form complex branched variform barriers used for such diverse functions as controlling blood flow and blood cell delivery into the circulation, sealing off the hematopoietic/immunologic colonies and regulating their proliferation and differentration through paracrine secretion. (ajtmh.org)
  • receptors
  • This is achieved by use of the MHC (also known as HLA) 1 and 2 receptors, which along with the TCRs (T-cell receptors) bind the antigen in question and form a complex that allows the T cell to recognize the antigen. (statpearls.com)
  • Both CD4+ T cells and CD8+ T cells have the TCR (and the co-receptor CD3), but (as evidenced by their name) their other co-receptors vary. (statpearls.com)
  • T cells are often implicated in transplant rejection, and their surface receptors are pharmacologic targets for anti-rejection drugs. (statpearls.com)
  • T cells also have various chemokine/co-receptors on their surfaces. (statpearls.com)
  • The CCR5 and CXCR4 (found mostly on CD4+ T cells) chemokine receptors are of particular importance because they are the targets of HIV. (statpearls.com)
  • T regulatory cells have CD4 and CD25 added as co-receptors for their TCRs. (statpearls.com)
  • As mentioned above, T cells have numerous other biochemical receptors on their surface, and these largely depend on the T cell's function. (statpearls.com)
  • TCRs (T-cell receptor and their co-receptors, such as CD3 and CD8) found on these cells form a complex with the MHC 1 receptor and the antigen in question. (statpearls.com)
  • protein
  • A protein with a molecular weight of about 50,000 daltons was subsequently described and shown to augment the immune responses of both immature and mature T-cells. (wikipedia.org)
  • Purification of protein from bovine-derived stromal cell supernatants produces a substantially homogeneous factor, free of extraneous materials. (wikipedia.org)
  • Stromal cells showing signs of intense protein secretion and increased branching were present. (ajtmh.org)
  • They do this by secreting increased levels of a special protein molecule called cytokines that act on other cells. (chemocare.com)
  • activate
  • This modification may more effectively activate the recipient's immune system to attack their hematological malignancy by not damaging the recipient's immune cells prior to cellular infusion. (clinicaltrials.gov)
  • cellular
  • All suitable patients showing evidence of cellular uptake in the ileo-caecal region and/or small bowel at Visit 1 will be progressed to an identical second cell labeling and scanning session at Visit 2 (48 hours later). (clinicaltrials.gov)
  • Immunity
  • These cells play a vital role in both components of active immunity (cell-mediated and to some extent humoral immunity). (statpearls.com)
  • This type of immunity induces mast cell, basophil, and eosinophil activation leading to an increase in serum IgE levels and, therefore, fosters the eradication of helminthes and venoms. (docplayer.net)
  • human
  • Colour-enhanced scanning electron microscope (SEM) of a human lymphocyte cell. (sciencephoto.com)
  • Two main types of lymphocytes occur in the human body: T-cells and B-cells. (sciencephoto.com)
  • This goal is addressed through studies which aim: 1) to fully characterize the profile and regulation of TLR10 expression within the human B cell lineage;2) to characterize the in vitro function of TLR10 in modulating B cell activity;3) to define the role of TLR10 in the modulating class switch recombination;4) to examine the role of TLR10 in regulating antigen-specific adaptive immune responses. (grantome.com)
  • Toll-like receptor 10 is an uncharacterized immune receptor that is highly expressed on human B cells. (grantome.com)
  • Lymphoma
  • Extranodal NK/T-cell lymphoma most commonly affects the nasal cavity and other mucosal sites of the upper aerodigestive tract. (uptodate.com)
  • Based on currently available data, treatment of nasal NK/T-cell lymphoma should consist of radiotherapy, with or without multiagent chemotherapy. (uptodate.com)
  • chemotherapy
  • More research is required to ascertain the role of high-dose chemotherapy with stem cell rescue and that of non-multidrug resistance-related chemotherapeutic agents. (uptodate.com)
  • gamma
  • Under viral attack CD-4+ T-cells fail to mature, fail to produce IL-2 and gamma interferon, and consequently fail to coordinate CD-8 responses to viruses. (wikipedia.org)
  • A small portion of T cells in the body have delta and gamma chains and recognize different antigen types than other T cells. (statpearls.com)
  • Lymphatic
  • The white pulp increased due to enlargement of lymphatic nodules, and in the periarterial lymphatic sheath, plasma cells invade the area around the central artery. (ajtmh.org)