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  • stem cell
  • Corbeil D, Joester A, Fargeas CA, Jaszai J, Garwood J, Hellwig A, Werner HB, Huttner WB (2009) Expression of distinct splice variants of the stem cell marker prominin-1 (CD133) in glial cells. (springer.com)
  • Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA. (nih.gov)
  • Drosophila neuroblasts (NBs) represent an excellent experimental model for studying neural stem cell (NSC) biology. (biologists.org)
  • After a brief stay at the Karolinska Institute to acquaint himself with the rapid developments of the neural stem cell field, Benedikt returned to Munich and obtained a position as a lecturer and senior lecturer at the Ludwig Maximilians University, Munich. (abcam.com)
  • Stem cells are classically defined as undifferentiated cells possessing a unique ability to produce differentiated daughter cells whilst their population maintains its stem cell state by self-renewal ( Weissman, 2000 ). (frontiersin.org)
  • Editor's note: The stem cell world has been rich with conferences in the past week or so. (nature.com)
  • I hope to have very brief notes on Cold Spring Harbor Laboratory and Stanford's interdisciplinary program on stem cell policy over the next few days. (nature.com)
  • Sally Temple PhD from the New York Stem Cell Institute showed that cells of the retinal pigment epithelium (RPE)collected from the sub-retinal fluid discarded after retinal surgeries can be isolated from human eye, expanded, and differentiated into a variety of cells (e.g. retinal cells, neurons, fat, chondrocytes, and bone). (nature.com)
  • The second day of the International Stem Cell Symposium: Frontiers in Neural Stem Cells had an equally impressive lineup of speakers with surprisingly passionate requests for scientific diversity and support for basic research funding. (nature.com)
  • Experimental approaches aimed at correcting deficits in hippocampal circuits in mTLE include attempts to replace GABAergic interneurons through neural stem cell transplantation. (intechopen.com)
  • Some astrocytes localize in the neurogenic niches of the adult brain, retain the stem cell properties throughout the life span and are the source for the adult neuro-and glio-genesis. (fmcpaware.org)
  • In stroke, MFG-E8 promotes neural stem cell proliferation and their migration toward the ischemic brain tissues. (frontiersin.org)
  • Adherent self-renewable human embryonic stem cell-derived neural stem cell line: functional engraftment in experimental stroke model. (nih.gov)
  • The power of these models has been widely discussed, but the potential pitfalls of stem cell differentiation in this research are less well described. (springer.com)
  • Following these guidelines will help researchers to ensure that robust and meaningful data is generated, enabling the full potential of stem cell differentiation for disease modeling and regenerative medicine. (springer.com)
  • To ensure the generation of meaningful results, stem cell derived cultures will therefore need to undergo thorough characterization to identify the composition and functionality of the differentiated cells. (springer.com)
  • The new findings have recently been published in Cell Stem Cell. (innovations-report.com)
  • Stem cell self-renewal and differentiation must be carefully controlled during development and tissue homeostasis. (jneurosci.org)
  • UCSF scientists have discovered a new stem cell in the developing human brain. (redorbit.com)
  • This discovery has the potential to transform our understanding of the development and evolution of the human neocortex, the most uniquely human part of the central nervous system," says the senior author of the study, neurologist Arnold Kriegstein, MD, PhD, director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF. (redorbit.com)
  • They characterized two kinds of cells within the region""both the novel neural stem cell and its daughter cell, known as the transit amplifying cell. (redorbit.com)
  • The stem cell undergoes asymmetrical cell division, giving rise to two distinct daughter cells""one a copy of the original stem cell, the other a transit amplifying cell. (redorbit.com)
  • migrate
  • Numerous birthdating studies, using nucleotide analogues such as tritiated thymidine and bromodeoxyuridine, which incorporate themselves into newly synthesized DNA, show that this occurs in an "inside out" manner: cortical layer VI (the innermost layer) is formed first, and then layer V, and so on, such that each wave of cells has to migrate past the one before. (scienceblogs.com)
  • pial
  • Soon after their final cell division, newborn cells embark on a radial migration toward the pial surface on the outer surface of the neural tube. (scienceblogs.com)
  • Cells undergoing somal translocation have a long, branched leading process which spans the thickness of the cerebral wall.and comes into contact with the pial surface, and a short and transient trailing process. (scienceblogs.com)
  • During this polarization, the neuron adheres to a radial glial cell process and initiates radial migration through the cell-sparse but axon-rich intermediate zone (IZ) towards the pial surface. (biomedcentral.com)
  • scaffold
  • The integrity of this radial glial scaffold is well maintained throughout development. (nig.ac.jp)
  • Our study uncovers an extrinsic molecular regulator for the maintenance of radial glial scaffold integrity during development. (nig.ac.jp)
  • Mice deficient in CXCL12 or its receptor CXCR4 show disrupted radial glial scaffold in their spinal cords, which consequentially causes invasion of boundary cap cells into the spinal cord. (nig.ac.jp)
  • neuroepithelium
  • Here, using further optimized 3D culture that allows highly selective induction and long-term growth of human ES cell (hESC)-derived cortical neuroepithelium, we demonstrate unique aspects of self-organization in human neocorticogenesis. (pnas.org)
  • NSCs
  • Neural stem cells (NSCs) can be defined as self-renewing, multipotent cells that are present in both the embryonic and adult brain. (frontiersin.org)
  • Forwarding this agenda requires a better understanding of the neurobiology of neural stem cells (NSCs) and the factors that regulate them in the developing brain. (frontiersin.org)
  • Derek van der Kooy, PhD from the University of Toronto showed evidence that a small population of leukemia inhibitory factor (LIF) sensitive primitive neural stem cells (NSCs) is preserved in the adult forebrain (approximately 5-10 cells in adult mice). (nature.com)
  • Primitive NSCs can be activated to replace the definitive neural stem cells lost to chemical stress. (nature.com)
  • generates
  • Studies have indicated that the direct enrichment method generates a heterogeneous population of cells that may contain residual undifferentiated stem cells that could lead to tumor formation in vivo. (nih.gov)
  • mitotic
  • Recent studies in mammalian tissue culture cells suggest that the apically localised atypical protein kinase C (aPKC) is important for the planar orientation of the mitotic spindle in dividing epithelial cells. (biologists.org)
  • mice
  • The massive number of cells within the OSVZ of humans "tells us we have to be careful when modeling human brain diseases in mice," says Kriegstein. (redorbit.com)
  • epithelial
  • Weigmann A, Corbeil D, Hellwig A, Huttner WB (1997) Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. (springer.com)
  • Ependymocytes, choroid plexus cells and retinal pigment epithelial cells line the ventricles or the subretinal space. (fmcpaware.org)
  • Epithelial cells mostly orient the spindle along the plane of the epithelium (planar orientation) for mitosis to produce two identical daughter cells. (biologists.org)
  • From our work we conclude that, similar to what has been reported in mammalian tissue culture cells, Drosophila aPKC is required for spindle planar orientation and apical exclusion of Pins during symmetric division of epithelial cells. (biologists.org)