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  • patient's
  • One major drawback is that the tumor antigens used to "feed" the dendritic cells are from lab-grown tumors, not the patient's own. (medicalnewstoday.com)
  • When the dendritic cells are returned to the patient's body, they are primed to recognize types of small vesicle called exosomes . (medicalnewstoday.com)
  • In the above-mentioned study, vaccine generation was constrained by the time required to obtain peptide antigen from each patient's autologous cultured tumor cell line. (aacrjournals.org)
  • Once reintroduced into the patient's system, the EVIRs are engineered to recognize exosomes that transport molecules between cells, sometimes assisting in the spread of cancer. (issels.com)
  • For many years, disappointing results have been generated by many investigations, which have utilized a variety of immunologic strategies to enhance the ability of a patient's immune system to recognize and eliminate malignant cells. (frontiersin.org)
  • The impressive clinical responses observed in many types of cancer have convinced even the most skeptical clinical oncologists that a patient's immune system can recognize and reject his tumor if appropriate strategies are implemented. (frontiersin.org)
  • adoptive
  • The alternate approach is to augment cellular immune responses either through non-specific stimulation such as Bacillus Calmette-Guerin (BCG), Corynebacterium parvum (CP), poly I:C, etc. (25-28), or through adoptive transfer of specifically sensitized lymphoid cells (29-31). (springer.com)
  • Datta S.K., Trentin J.J., McCormick K.J. (1981) Prevention of Primary Simian Adenovirus Type 7 (SA 7 ) Tumors in Hamsters by Adoptive Transfer of Lymphoid Cells: Role of Different Cell Types. (springer.com)
  • Circumventing human MHC-restriction renders the CAR T cell approach as a universal treatment, broadening the potential applicability of adoptive T cell therapy. (frontiersin.org)
  • A. Tumor burden in individual PyMT ChOVA mice following adoptive transfer of 5×10 6 naïve OT-I cells (red lines, N=7) or untreated controls (black line, N=12). (nih.gov)
  • Indeed, whereas expansion of MDSCs, in both murine and human tumor bearers, results in reduced immune surveillance and antitumor cytotoxicity, placing an obstacle to the effectiveness of anticancer therapies, adoptive transfer of MDSCs has shown therapeutic benefits in autoimmune disorders. (frontiersin.org)
  • We examined the tumor mass as a potential site of activation after adoptive transfer of naive tumor-specific CD8 T cells. (pubmedcentralcanada.ca)
  • Activated CD8 T cells were present in tumors within 24 h of adoptive transfer and proliferation of these cells was also evident 4-5 d later in mice treated with FTY720 to prevent infiltration of cells activated in LNs. (pubmedcentralcanada.ca)
  • murine
  • We show that murine fibrosarcoma tumor cells that secrete vesicle-bound antigen grow slower than tumors that secrete soluble antigen in immunocompetent, but not in immunodeficient, host mice. (aacrjournals.org)
  • However, the d isomer was significantly more effective in reversing the suppression of T cells created by IDO-expressing dendritic cells, using both human monocyte-derived dendritic cells and murine dendritic cells isolated directly from tumor-draining lymph nodes. (aacrjournals.org)
  • In murine tumor models, IDO + dendritic cells displaying a plasmacytoid phenotype (CD11c + B220 + ) have been found at increased levels in tumor-draining lymph nodes ( 22 ). (aacrjournals.org)
  • The combination of mocetinostat and a murine PD-L1 antibody antagonist demonstrated increased anti-tumor activity compared to either therapy alone in two syngeneic tumor models. (springermedizin.de)
  • This paper reviews recent findings in murine models regarding the antitumoral mechanisms of DC-based vaccination, covering issues related to antigen sources, the use of adjuvants and maturing agents, and the role of DC subsets and their interaction in the initiation of antitumoral immune responses. (frontiersin.org)
  • immunogenic
  • You SB-505124 SB-505124 can find three wide patterns of latent gene appearance each connected with particular tumors: type 3 latency where all nine latency protein including six nuclear antigens (EBNAs) two membrane protein (LMPs) as well as the secreted BARF1 gene item are expressed sometimes appears in the extremely immunogenic lymphomas that develop in immunocompromised sufferers such as for example recipients of HSCT or solid body organ transplantation. (boothampitheatre.com)
  • We call this phenomenon cross-dressing, which alludes to the fact that the dendritic cells acquire immunogenic antigens from the tumor and directly display them on their own surface. (medicalnewstoday.com)
  • CTLs
  • The antigens recognized on target cells by CTLs are "pepMHC" complexes, i.e., short peptides bound to protein products of class I major histocompatibility (MHC) genes. (pnas.org)
  • myeloid cells
  • Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid cells with major regulatory functions and rise during pathological conditions, including cancer, infections and autoimmune conditions. (frontiersin.org)
  • Inability to reinstate physiological myelopoiesis would fall in an "emergency state" that perpetually reprograms myeloid cells toward suppressive functions. (frontiersin.org)
  • Immunologic stress, such as infection and cancer, modifies the magnitude and composition of the hematopoietic output, a feature of immune regulation defined as "emergency" hematopoiesis, to guarantee proper supply of both lymphoid and myeloid cells to increased demand ( 1 ). (frontiersin.org)
  • However, it is not known whether intratumoral DCs/myeloid cells or tumor cells can activate naive CD8 T cells within the tumor mass. (pubmedcentralcanada.ca)
  • infiltration
  • We therefore examined the ability of tumor lysate-pulsed DCs to activate peripheral tumor-reactive CTL activity and CD8+ T-cell infiltration into tumors in situ in recurrent malignant glioma patients. (aacrjournals.org)
  • Rapid reconstitution of anti-tumor recognition and enhanced tumor infiltration of treated NK cells was monitored by 24 h co-incubation of HNSCC tumor spheroids with cetuximab (1 μg/ml) and was characterized by increased IFN-γ and TNFα secretion. (frontiersin.org)
  • genes
  • We now have detailed knowledge of the molecular basis of cancer to allow a more "personalized" treatment based on genomic sequencing of an individual's cancer cells to identify specific mutations in genes. (sciencemag.org)
  • Despite this, many fundamentally important questions remain unanswered: what is the connection between germ-cell specific genes and tumours? (biomedcentral.com)
  • monoclonal
  • The present paper examines the role of O -acetyl-GD2 in tumor biology as well as the available preclinical data of anti- O -acetyl-GD2 monoclonal antibodies. (hindawi.com)
  • suppressive
  • Myeloid-derived suppressor cells (MDSCs) are a major component of the immune-suppressive network described in cancer and many other pathological conditions. (rupress.org)
  • Myeloid-derived suppressor cells (MDSCs) are one of the major components of the immune-suppressive network responsible for T cell defects in cancer. (rupress.org)
  • cancer
  • Our immune system is excellent at destroying and removing damaged, faulty, or old cells, but in the case of cancer, it tends to need a little help. (medicalnewstoday.com)
  • In cancer cells, they are thought to play a role in metastasis, helping cancer travel to, and thrive in, distant parts of the body. (medicalnewstoday.com)
  • In cancer, IDO activity may help promote acquired tolerance to tumor antigens. (aacrjournals.org)
  • In humans, expression of IDO by ovarian and colorectal cancer cells has been found to be a significant predictor of poor prognosis ( 9 , 10 ). (aacrjournals.org)
  • A research team at Vanderbilt University in Nashville began exploring the idea of blocking glutamine from cancer cells as a possible form of treatment. (issels.com)
  • They focused on ASCT2, a protein that transports glutamine to cancer cells as well as other parts of the body. (issels.com)
  • While the body's immune system is extremely capable when it comes to fighting viruses, bacteria and other invaders, cancer cells often demonstrate a remarkable ability to evade detection. (issels.com)
  • Neuroblastoma gets its name from neuroblasts, which are immature cells where this form of cancer develops. (issels.com)
  • Such bispecific antibodies targeting CD47 along with tumor-associated antigens may be an effective strategy for selectively eliminating tumor cells that can be broadly applied to cancer. (aacrjournals.org)
  • Cancer Cell. (nih.gov)
  • PSCA is expressed in most prostate cancer specimens, including high-grade prostatic intraepithelial neoplasia, primary androgen-dependent tumors, and hormone-refractory metastases. (aacrjournals.org)
  • Although seminomas are the most common form of testicular cancer, dysgerminomas are relatively rare, as are intracranial germinomas, which account for only 4% of all pediatric brain tumors. (jimmunol.org)
  • As the name implies, bone cancer is a malignant tumor that forms in bone tissue. (issels.com)
  • As a result, research into the link between cancer and fat cells has focused on this form of the disease. (issels.com)
  • According to co-author Dr. Jorge Moscat, this control was necessary to get a clear understanding of the communication pathways between cancer and fat cells. (issels.com)
  • Can Cancer Cells Be "Starved" to Death? (issels.com)
  • Interestingly, CD73 is highly expressed in many human solid tumors ( 24 - 29 ), and its elevated expression and activity are associated with tumor invasiveness and metastasis ( 30 , 31 ) and with shorter patient survival time ( 32 ), indicating that CD73 is closely involved in cancer progression. (aacrjournals.org)
  • Second, CD16-CR T cells can target multiple cancer types provided that TAA-specific mAbs with the appropriate specificity are available. (frontiersin.org)
  • Any cancer can be targeted that has a known cell surface marker that is expressed in a tumor-restricted fashion. (aacrjournals.org)
  • Promising results have been obtained in many animal models using these approaches, but they have rarely led to objective and durable anti-tumor effects in cancer patients ( 11 - 14 ). (pnas.org)
  • Checkpoint inhibitor therapy has led to major treatment advances for several cancers including non-small cell lung cancer (NSCLC). (springermedizin.de)
  • Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE et al (2015) Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. (springermedizin.de)
  • Brahmer J, Reckamp KL, Baas P, Crino L, Eberhardt WE, Poddubskaya E et al (2015) Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. (springermedizin.de)
  • Three talks address the statement that tumor recognition and/or elimination cannot happen in an otherwise unmanipulated cancer-bearing individual. (aacrjournals.org)
  • Besides MAGEA1, BAGE, and GAGE1 discovered by T-cell epitope cloning, SEREX very soon displayed more tumour antigens with a cancer/testis restricted expression profile (SSX2, NY-ESO-1, and SYCP-1). (biomedcentral.com)
  • The term "cancer-testis (CT) antigen" was introduced by Chen et al. (biomedcentral.com)
  • These findings should advance our current knowledge in devising antitumor immunotherapeutic remedies to complement virotherapy-mediated tumor destruction and restrict cancer remission in clinical settings. (aacrjournals.org)
  • ref. 31 ) cell lines were kindly provided by Dr. J. Xiang (Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada) and Dr. E. Podack (University of Miami School of Medicine, Miami, FL), respectively. (aacrjournals.org)
  • Dendritic cells (DCs) play a pivotal role in the orchestration of immune responses, and are thus key targets in cancer vaccine design. (frontiersin.org)
  • However, in certain animal tumor models elevated CIN negatively impacts upon organism fitness, and is poorly tolerated by cancer cells. (dtu.dk)
  • We also observed this paradoxical relationship between CIN and prognosis in ovarian, gastric, and non-small cell lung cancer, with poorest outcome in tumors with intermediate, rather than extreme, CIN70 scores. (dtu.dk)