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  • phenotype
  • The results showed that interaction with CD25 high CD4 + regulatory T cells (Tregs) caused DC to take on very different properties than contact with naive or memory phenotype T cells. (jimmunol.org)
  • In this study, we find that unlicensed mature MHC class I-deficient splenic NK cells show gain-of-function and acquire a licensed phenotype after adoptive transfer into wild-type (WT) hosts. (rupress.org)
  • Rabbit adipose mesenchymal stem cells were used for the purpose of studying acquisition of the chondrogenic phenotype over time at 1, 14 and 28 days after in vitro incubation with differentiation media, using nano-liquid chromatography electrospray ionization tandem mass spectrometry analysis. (biomedcentral.com)
  • Our results indicate that CSC phenotype is dynamic and may be acquired through dedifferentiation and Oct4 is a positive regulator of tumor dedifferentiation. (aacrjournals.org)
  • The analogs showed a different behavior toward cells with acquired resistance against the normal product disorazole C1 , which owe their resistance phenotype at the least in part to overexpression in the ABCB1 p glycoprotein pump. (peptidecost.com)
  • differentiation
  • Leukemia cells are superior to hematopoietic cells with a normal differentiation potential in buffering cellular stresses, but the underlying mechanisms for this leukemic advantage are not fully understood. (sigmaaldrich.com)
  • Although canonical autophagy defects attenuated cell cycling, proliferation and differentiation potential, the leukemia cells retained their abilities for mitochondrial clearance and for maintaining low levels of reactive oxygen species (ROS) and apoptosis. (sigmaaldrich.com)
  • DC maturation involves multiple alterations, including changes in Ag processing/presentation and expression of MHC molecules, costimulatory molecules, cytokines, and chemokines, which affect their ability to attract and regulate the differentiation and activation of T cells. (jimmunol.org)
  • Previous research by the team characterized the dynamic regulatory activities of such transcription factors during cellular differentiation from immature cell (monoblast) to developed (monocyte-like) cell using human acute monocytic leukemia cell lines (THP-1). (bio-medicine.org)
  • Our results indicate that CAP350 may act as an adaptor between adherens junctions and microtubules, thus regulating epithelial differentiation and contributing to the definition of cell architecture. (sigmaaldrich.com)
  • The aims of the present work are to investigate whether human CD34+ cells, isolated after 1 wk of coculture with neonatal ventricular myocytes, possess molecular and functional properties of cardiomyocytes and to discriminate, using a reporter gene system, whether cardiac differentiation derives from a (trans)differentiation or a cell fusion process. (mpg.de)
  • The dedifferentiated melanoma cells showed significantly decreased expression of melanocytic markers and acquired many features associated with CSCs such as multipotent differentiation capacity and expression of melanoma CSC markers such as ABCB5 and CD271. (aacrjournals.org)
  • epidermal growth f
  • The researchers began by studying four different types of breast cancer cells that were able to keep growing despite treatment with lapatinib, a powerful drug that targets two growth pathways commonly disrupted in breast cancer, HER2 and epidermal growth factor receptor. (medicalxpress.com)
  • Gefitinib is a targeted cancer therapy that blocks a tyrosine kinase enzyme to treat non-small cell lung cancers caused by mutations in the epidermal growth factor receptor. (medicalxpress.com)
  • Acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) is a critical issue that needs to be overcome in the treatment of patients with non-small cell lung cancer (NSCLC) harboring EGFR activating mutations. (spandidos-publications.com)
  • wholly-owned subs
  • Universal Cells has become a wholly-owned subsidiary of Astellas following the close of the acquisition. (forimmediaterelease.net)
  • Headquartered in Marlborough, Mass. , and supported by a research team in Tsukuba, Japan , AIRM is a wholly-owned subsidiary of Astellas and serves as the Company's global hub for regenerative medicine and cell therapy research in ophthalmology and other therapeutic areas that have few or no available treatment options. (forimmediaterelease.net)
  • UTEK Corporation and NeoStem , Inc. have announced that NeoStem has acquired Stem Cell Technologies , Inc., a wholly owned subsidiary of UTEK, in a stock for stock transaction. (technologynetworks.com)
  • NYON, Switzerland & POTSDAM, Germany--( BUSINESS WIRE )--Elanix Biotechnologies AG (FSE: ELN), a developer of tissue regeneration products, announced today that its wholly owned subsidiary, Repair-A Ltd, has acquired a third cell free protein complex (CFPC ® ) product discovered in the Tec-Pharm laboratories of Professor Lee-Ann Laurent Applegate. (businesswire.com)
  • therapies
  • According to Brian Atwood, President and CEO of Cell Design Labs, Inc., "Bringing our robust technology platforms under the Gilead umbrella, with its outstanding research and development capabilities and commitment to innovation, provides an exciting path forward for the development of the next generation of living therapies for patients with cancer. (globenewswire.com)
  • We believe that bringing Cell Design Labs together with Gilead provides the potential for a disruptive new wave of cell therapies for cancer. (globenewswire.com)
  • Cell Design Labs is a biotherapeutics company pioneering breakthrough science to develop disruptive cell-based therapies. (globenewswire.com)
  • Additionally, Cell Design Labs is developing several pre-clinical product candidates, including therapies for prostate cancer and hepatocellular carcinoma that use the synNotch technology. (deutschland-schraubt.de)
  • Cell Design Labs' talented team of cell biology experts will augment and accelerate our work to bring forward new generations of CAR T and TCR therapies, building on our acquisition of Kite earlier this year and our efforts to improve care for people with advanced cancers. (deutschland-schraubt.de)
  • We believe that by becoming part of the Gilead and Kite organizations, we will be better able to advance a new class of cell-based therapies to help people for generations to come. (deutschland-schraubt.de)
  • This additional capability will further enable Astellas to develop potential innovative cell therapies for numerous diseases with high unmet medical needs. (forimmediaterelease.net)
  • Universal Cells, Inc. is a Seattle -based biotech developing, licensing and commercializing stem cell therapies that overcome immune rejection and can be used to create true off-the-shelf therapeutic products. (forimmediaterelease.net)
  • proliferation
  • Administration or over-expression of IL-35 has been shown to confer protection to the development of various experimental autoimmune diseases through the suppression of CD4 + T cell proliferation and function. (frontiersin.org)
  • protein
  • The researchers-co-directed by Kornbluth and Neil Spector, M.D., associate professor of medicine at Duke-identified a protein that effectively shuts down the signals that tell a cell to die, enabling cancer cells to keep growing. (medicalxpress.com)
  • Meanwhile, the cost of protein analysis using nano-flow liquid chromatography electrospray ionization tandem mass spectrometry (nLC-MS/MS) now allows for true protein measurements to be made at the tissue or even single cell level. (biomedcentral.com)
  • Alpha-catenin-dependent recruitment of the centrosomal protein CAP350 to adherens junctions allows epithelial cells to acquire a columnar shape. (sigmaaldrich.com)
  • Here, we report that the centrosomal microtubule (MT)-binding protein CAP350 localises at adherens junctions in epithelial cells. (sigmaaldrich.com)
  • Umbilical cord blood CD34+ cells were isolated by a magnetic cell sorting method, transduced with a lentiviral vector carrying the enhanced green fluorescent protein (EGFP) gene, and seeded onto primary cultures of spontaneously beating rat neonatal cardiomyocytes. (mpg.de)
  • under these conditions we found that 100% of EGFP+ cells were also red fluorescent protein positive, suggesting cell fusion as the mechanism by which cardiac functional features are acquired. (mpg.de)
  • In this study, we showed that expression of Oct4 gene or transmembrane delivery of Oct4 protein promoted dedifferentiation of melanoma cells to CSC-like cells. (aacrjournals.org)
  • This acquisition would significantly expand Cell Biosciences' protein analysis business to include a global infrastructure and a broad protein analysis product portfolio. (technologynetworks.com)
  • Cell Biosciences is a private life sciences company established in 2004, and is focused on revolutionizing protein and biomarker research. (technologynetworks.com)
  • The combination of Cell Biosciences and Alpha Innotech would create a global protein analysis business with a broad product line featuring both traditional and novel protein analysis technologies. (technologynetworks.com)
  • We identified Mod5, a yeast transfer RNA isopentenyltransferase lacking glutamine/asparagine-rich domains, as a yeast prion protein and found that its prion conversion in yeast regulated the sterol biosynthetic pathway for acquired cellular resistance against antifungal agents. (sciencemag.org)
  • umbilical cord
  • Virus from the U.S. patient was isolated and characterized and shown to be related to HTLV subgroup I. The virus was also transmitted into normal human T cells from umbilical cord blood of a newborn. (sciencemag.org)
  • To determine if autologous human umbilical cord blood infusion in children with acquired hearing loss is safe, feasible, improves inner ear function, audition and language development. (clinicaltrials.gov)
  • Recent experiments using human umbilical cord blood treatment of a mouse and guinea pig models have demonstrated hair cell re-growth following acquired sensorineural loss as well as partial restoration of ABR. (clinicaltrials.gov)
  • 2016
  • Since its founding in 2016, Cell Design Labs has raised $34.4 million. (globenewswire.com)
  • Elanix Biotechnologies Ltd. acquired Repair-A in September 2016 and is in the process of scaling up marketing of the products in Switzerland and initiating commercialization worldwide. (businesswire.com)
  • 2017
  • FOSTER CITY, Calif. & SANTA MONICA, Calif. --(BUSINESS WIRE)--Dec. 7, 2017-- Gilead Sciences, Inc. (Nasdaq: GILD) and its cell therapy subsidiary Kite announced today that they have entered into a definitive agreement under which they have agreed to acquire Cell Design Labs, Inc. , gaining new technology platforms that will enhance research and development efforts in cellular therapy. (deutschland-schraubt.de)
  • immature
  • In general, DC are considered to switch from an immature state, in which they are adept at Ag capture but are poor stimulators of T cells, into a mature state, in which they are potent T cell activators ( 1 ). (jimmunol.org)
  • This is associated with two contrasting functions of DC: the maintenance of self-tolerance through abortive stimulation of T cells by immature DC and the induction of immune responses via the productive activation of T cells by mature DC ( 2 ). (jimmunol.org)
  • knockdown
  • The c-Myc expression alterations were mediated by upregulation of FBXW7, as evidenced through FBXW7-siRNA knockdown experiments that resulted in enhanced cell sensitivity to anticancer agents. (kumamoto-u.ac.jp)
  • Furthermore, ShRNA mediated knockdown of Oct4 in dedifferentiated cells led to diminished CSC phenotypes. (aacrjournals.org)
  • In contrast, the HeLa DZR cells showed only small cross resistance to the dictyostatin analogs that was thoroughly reversed by ABCB1 knockdown. (peptidecost.com)
  • Gilead
  • We've already integrated THROTTLE™ Switch into our CAR-T pipeline and look forward to exploring the full depth and breadth of the technologies of Gilead, Kite and Cell Design Labs to expand the cell therapy toolbox. (globenewswire.com)
  • Under the terms of the agreement, Gilead will acquire all of the outstanding shares of Cell Design Labs , which includes the approximately 12.2 percent of shares of Cell Design Labs that are currently held by Kite, for up to approximately $567 million . (deutschland-schraubt.de)
  • cytokines
  • Indirect, infection-induced signals that influence DC behavior include cytokines as well as molecules released by dying cells ( 8 , 9 , 10 ). (jimmunol.org)
  • In response to allergens, lung ILC2s produce T helper 2 cell type cytokines inducing T cell-independent allergic lung inflammation. (terryfoxlab.ca)
  • tissues
  • Up-regulation of CCR7, a receptor for CCL19 and CCL21, has been shown to be crucial for the migration of DC from peripheral tissues into T cell areas of draining lymph nodes in response to inflammation ( 5 , 6 ). (jimmunol.org)
  • Hence, NK cells use inhibitory receptors to assess the surface of self-tissues for MHC class I expression, providing a line of defense against pathogens and abnormal cell growth. (rupress.org)
  • Egress from the BM is generally accepted as a marker of mature conventional NK cells, as cells isolated from peripheral lymphoid tissues demonstrate effector function upon stimulation. (rupress.org)
  • cellular
  • PhD, Scientific Founder, Cell Design Labs and Chair of the Department of Cellular and Molecular Pharmacology at the University of California, San Francisco . (deutschland-schraubt.de)
  • Additionally, as the HeLa DZR cells have been generated by just one exposure on the mutagen ethyl methane sulfonate followed by a stepwise improved disorazole C1 exposure, its possible that resistance mechanisms apart from elevated ABCB1 exist, but these never seem to influence cellular sensitivity towards the dictyostatin analogs. (peptidecost.com)
  • The hUCB reanimation, cell processing and product infusion will occur at Florida Hospital for Children and the Florida Hospital Center for Cellular Therapy. (clinicaltrials.gov)
  • HTLV-infected cells express specific virus structural and virus-induced cellular proteins. (cdc.gov)
  • CSCs
  • We previously established an LGR5+ human colorectal cancer stem-cell-enriched cell line (colorectal CSCs) that expresses well-accepted colorectal CSC markers and that can dynamically switch between proliferative and drug-resistant non-cycling states. (kumamoto-u.ac.jp)
  • We performed this study to elucidate the molecular mechanisms responsible for evading cell death in colorectal CSCs mediated by anticancer agents. (kumamoto-u.ac.jp)
  • During the cell cycle arrest caused by anticancer agents, we found that c-Myc expression was substantially decreased in colorectal CSCs. (kumamoto-u.ac.jp)
  • There is enormous interest to target cancer stem cells (CSCs) for clinical treatment. (aacrjournals.org)
  • nonspecific
  • Systemic acquired resistance (SAR) is a nonspecific defense response in plants that is associated with an increase in the endogenous level of salicylic acid (SA) and elevated expression of pathogenesis-related (PR) genes. (plantcell.org)
  • gene
  • Using CRISPR/Cas9 deletion of the canonical autophagy-essential gene Atg7, we found that erythroleukemia K562 cells are armed with two sets of autophagic machinery. (sigmaaldrich.com)
  • Both soluble factors and cell-associated molecules were shown to be involved in Treg modulation of DC, with lymphocyte activation gene 3 (LAG-3) playing a predominant role in driving maturation-associated changes. (jimmunol.org)
  • The allergen-experienced ILC2s exhibited a gene expression profile similar to that of memory T cells. (terryfoxlab.ca)
  • Genome-wide gene expression analysis of this reprogrammed cell showed monocyte-like gene expression profile, demonstrating that reconstruction of a functional TRN can be achieved by introducing core TRN elements into unrelated cell types. (bio-medicine.org)
  • The company is developing two propriety technology platforms: synNotch™, a synthetic gene expression system that responds to external cues which, among other applications, can be deployed to engineer chimeric antigen receptor T (CAR T) cells that require dual antigen recognition for activation, and Throttle™, an "on switch" that modulates CAR T activity using small molecules. (deutschland-schraubt.de)
  • Acquired and inherited basal cell carcinomas and the patched gene. (semanticscholar.org)
  • receptor
  • By re-engineering the external and internal portions of the naturally occurring Notch receptor, and engineering these unique constructs into a patient's immune cells, the patient's T cells can be instructed to detect new molecular targets and to turn on new genes. (globenewswire.com)
  • With this approach, the synNotch receptor confers extremely versatile sense-and-response functionality to T cells, which already have the ability to migrate throughout the body to find targets. (globenewswire.com)
  • Only NK cells expressing an inhibitory Ly49 receptor specific for a cognate host MHC class I molecule show this gain-of-function. (rupress.org)
  • NK cells integrate signals received through target cell ligand-mediated engagement of activation receptors with those from inhibitory receptor engagement by MHC class I ligands expressed on targets. (rupress.org)
  • Thus, engagement of self-MHC-specific receptor "licenses" NK cells to be functionally competent to be triggered through their activation receptors. (rupress.org)
  • resistance
  • They found that in each case, the drug resistance could be traced to the presence of high levels of MDM2, which was found to be blocking cell death signals independent of whether p53 was activated. (medicalxpress.com)
  • In the present study, we evaluated the radiosensitizing effect of the novel Hsp90 inhibitor, NVP-AUY922 (AUY), on NSCLC cell lines harboring EGFR activating mutations and showing acquired resistance to EGFR-TKIs via any of several mechanisms. (spandidos-publications.com)
  • AUY was more effective against the gefitinib-resistant sublines with T790M mutation and MET amplification than against the parental cell lines, although the subline with stem cell-like properties showed more than a 10-fold higher resistance to AUY than the parental cell line. (spandidos-publications.com)
  • However, other approaches are required to overcome minor resistance to EGFR-TKIs, such as that observed in cells with stem cell-like properties. (spandidos-publications.com)
  • Several mechanisms of acquired resistance to EGFR-TKIs have been identified, such as secondary EGFR T790M ( 7 ) and minor mutations ( 8 ), and MET amplification ( 9 ). (spandidos-publications.com)
  • In addition, we also previously demonstrated an association between resistance to EGFR-TKIs and stem cell-like properties of the cells ( 10 ). (spandidos-publications.com)
  • human
  • In addition, EBI3, but not IL-27p28, is expressed in different human cancers like Hodgkin lymphoma or nasopharyngeal carcinoma cells ( 4 , 5 ). (frontiersin.org)
  • We sought to characterize the effects on human DC of contact with different subsets of activated CD4 + T cells. (jimmunol.org)
  • Four core TF genes of the monocyte TRN, identified using this approach, were introduced into human fibroblast cells, expression of which activated monocytic functions including phagocytosis, inflammatory response and chemotaxis. (bio-medicine.org)
  • Astellas will gain Universal Cells' proprietary Universal Donor Cell technology to create cell therapy products that do not require Human Leukocyte Antigen (HLA) matching, potentially overcoming a huge treatment challenge by reducing the risk of rejection. (forimmediaterelease.net)
  • Using the company's proprietary genome editing approach, the company engineers stem cells to prevent expression of polymorphic human leukocyte antigen (HLA) molecules, removing the cause of donor tissue rejection and creating Universal Donor Stem Cells that are compatible with every patient. (forimmediaterelease.net)
  • In a previous work (36), we showed that human cord blood CD34+ cells, when cocultured on neonatal mouse cardiomyocytes, exhibit excitation-contraction coupling features similar to those of cardiomyocytes, even though no human genes were upregulated. (mpg.de)
  • Elanix owns GMP certified Master and Working human cell banks with vast quantities of cells. (businesswire.com)
  • The acquisition relieves the Company of all milestone and royalty obligations under the license agreements for products claimed by the patents, such as products derived from the Company's proprietary HuCNS-SC® cells (purified human neural stem cells). (cnbc.com)
  • No. 7,166,277, has a term extending to 2024 and claims the use of human neural stem cells to remyelinate endogenous host cells, such as to treat spinal cord injury. (cnbc.com)
  • The Company's proprietary HuCNS-SC® cells (purified human neural stem cells) are currently in development as a potential treatment for a broad range of central nervous system disorders. (cnbc.com)
  • Several isolates of a human type-C retrovirus belonging to one group, known as human T-cell leukemia virus (HTLV), have previously been obtained from patients with adult T-cell leukemia or lymphoma. (sciencemag.org)
  • Recent evidence suggests that human T-cell leukemia virus (HTLV) infection occurs in patients with acquired immune deficiency syndrome (AIDS). (cdc.gov)
  • lymphoid
  • Despite these recent insights, the biological relevance for immunoregulation as well as the exact function of the cytokine IL-35, especially on non-lymphoid cells, remains elusive. (frontiersin.org)
  • Martinez-Gonzalez I, Matha L, Steer CA, Ghaedi M, Poon CF & Takei F. Allergen-experienced group 2 innate lymphoid cells acquire memory-like properties and enhance antigen non-specific allergic lung inflammation. (terryfoxlab.ca)
  • Group 2 innate lymphoid cells (ILC2s) in the lung are stimulated by inhaled allergens. (terryfoxlab.ca)
  • cancers
  • EGFR-TKIs show significant efficacy against non-small cell lung cancers (NSCLCs) harboring EGFR mutations, by inhibiting EGFR-AKT signaling ( 2 - 4 ). (spandidos-publications.com)
  • clinical
  • Therefore, these findings, which may be relevant to clinical bone marrow transplantation, suggest that neither exposure to MHC class I ligands during NK development in the BM nor endogenous MHC class I expression by NK cells themselves is absolutely required for licensing. (rupress.org)
  • With Biochrom we have a great opportunity to deliver an expanded portfolio of cell-culture media products to our global customers and address a growing demand for ready-to-use liquid solutions that drive safety and efficiency in the development and manufacture of clinical and commercial drug materials. (pharmaphorum.com)
  • Cell Design Labs is a pre-clinical stage company with significant expertise in custom cell engineering. (deutschland-schraubt.de)
  • Astellas will pay up to $102.5 million of upfront and milestones to acquire 100 percent ownership of Universal Cells depending on achievement of certain specified clinical milestones. (forimmediaterelease.net)
  • In a Phase I clinical trial in Pelizaeus-Merzbacher disease (PMD), a fatal myelination disorder in children, the Company has shown preliminary evidence of progressive and durable donor-derived myelination in all four patients transplanted with HuCNS-SC cells. (cnbc.com)
  • signals
  • Interactions between dendritic cells (DC) and T cells are known to involve the delivery of signals in both directions. (jimmunol.org)
  • Thus, presentation of Ag to specific T cells not only initiates signaling in the T cells, but also results in the delivery of signals to the APC. (jimmunol.org)
  • Cell-surface signaling (CSS) is a signal transfer system that allows Gram-negative bacteria to detect environmental signals and generate a cytosolic response. (frontiersin.org)
  • acquisition
  • Thus, self-MHC class I engagement by NK cell inhibitory receptors appears to be a fundamental element in acquisition of NK cell effector function. (rupress.org)
  • We have been very impressed with Universal Cells' capabilities in cell therapy, including Universal Donor Cell technology, which led us to our initial collaboration and ultimately this acquisition," commented Yoshihiko Hatanaka , President and CEO, Astellas. (forimmediaterelease.net)
  • The acquisition represents the recognition of the immense potential of our unique technology and of the outstanding work done by our team at Universal Cells. (forimmediaterelease.net)
  • Knocking down junction-located CAP350 inhibited the establishment of an apico-basal array of microtubules and impaired the acquisition of columnar shape in Madin-Darby canine kidney II (MDCKII) cells grown as polarised epithelia. (sigmaaldrich.com)
  • Cell Biosciences, Inc. and Alpha Innotech Corp. have announced that they have entered into a definitive agreement providing for the acquisition of Alpha Innotech by Cell Biosciences for $1.50 per share, or approximately $17.9 million in cash. (technologynetworks.com)
  • furthermore
  • IL-35 furthermore induces a distinct subset of Foxp3 − Treg (iTr35) and B cells ( 1 , 2 ). (frontiersin.org)
  • Furthermore, MDCKII cystogenesis was also defective in junctional CAP350-depleted cells. (sigmaaldrich.com)
  • Furthermore, selective pressure by antifungal drugs on yeast facilitated the de novo appearance of Mod5 prion states for cell survival. (sciencemag.org)
  • diseases
  • Together with AIRM, Astellas is focused on early discovery of cell therapy products for a variety of diseases through a combination of in-house research and external collaborations, using existing technologies and the creation of proprietary technologies. (forimmediaterelease.net)
  • In addition, antibodies to antigens expressed on the cell surface of HTLV-infected lymphocytes have been detected by an indirect immunofluorescent technique in sera from 19 (25%) of 75 AIDS patients (5), including patients with Kaposi's sarcoma alone (10/34), Pneumocystis carinii pneumonia alone (7/30), or patients with both diseases (2/11). (cdc.gov)
  • peripheral
  • Peripheral blood lymphocytes from one patient in the United States and two in France were cultured with T-cell growth factor (TCGF) an shown to express HTLV antigens. (sciencemag.org)
  • HTLV has been isolated from peripheral blood T-lymphocytes from several patients with AIDS (1, 2), and a retrovirus, related to but clearly distinct from HTLV, has been isolated from cells from a lymph node of a patient with lymphadenopathy syndrome (LAS) (3), a syndrome that may precede AIDS itself. (cdc.gov)
  • receptors
  • By expressing synNotch receptors in T cells, it is possible to create a programmable immune cell. (globenewswire.com)
  • In MHC class I-deficient hosts, natural killer (NK) cells are hyporesponsive to cross-linking of activation receptors. (rupress.org)
  • Transferred NK cells produce WT levels of interferon-γ after engagement of multiple activation receptors, and degranulate at levels equivalent to WT NK cells upon coincubation with target cells. (rupress.org)
  • To overcome this problem, most bacteria produce and secrete high-affinity iron chelating compounds called siderophores that can be recaptured by the cell through specific TonB-dependent receptors on the surface ( Wandersman and Delepelaire, 2004 ). (frontiersin.org)
  • maturation
  • By many criteria, Tregs inhibited DC maturation, inducing down-regulation of costimulatory molecules and T cell stimulatory activity. (jimmunol.org)
  • differentiate
  • When this reprogrammed cell binds to its sole intended target (i.e., a cancer cell), it triggers one or more specific molecular activities: locally modulating tumor defense mechanisms, delivering drugs such as checkpoint inhibitors, inducing a customized cytokine profile to supercharge the immune system, or encouraging T cells to differentiate into specific subtypes to convey long-term protection against cancer recurrence. (globenewswire.com)
  • The potential exists for the isolated VSELs to differentiate into specified cells that could be given to a patient where they would interact within the specific organ in order to repair degenerated, damaged or diseased tissue, the three "D's of aging. (technologynetworks.com)
  • leukemia
  • Selective induction of mitophagy was associated with the upregulation and localization of RAB9A on the mitochondrial membrane in both wild-type and Atg7(-/-) leukemia cells. (sigmaaldrich.com)
  • When the leukemia cells were treated with the alternative autophagy inhibitor brefeldin A or when the RAB9A was knocked down, this mitophagy was prohibited. (sigmaaldrich.com)
  • HTLV-1 has been associated with acute T-cell leukemia and a related, but clearly different, viral agent, HTLV-2, with 'hairy-cell' T-cell leukemia. (cdc.gov)
  • antigen
  • These findings suggest a new, indirect effector mechanism by which IL-35-responding antigen-presenting cells contribute to immune tolerance. (frontiersin.org)
  • Design Labs
  • We have been working with Cell Design Labs for almost 18 months, and truly appreciate the groundbreaking nature of their technology platforms," commented David D. Chang, M.D., Ph.D., Worldwide Head of Research and Development and Chief Medical Officer at Kite. (globenewswire.com)
  • As early investors in Cell Design Labs, we recognized the incredible power and promise of the technology platforms," commented Beth Seidenberg, M.D., General Partner at Kleiner Perkins and Director of Cell Design Labs. (globenewswire.com)
  • Citi acted as financial advisor and Cooley LLP acted as legal advisor to Cell Design Labs in connection with the transaction. (globenewswire.com)
  • The agreement includes an initial upfront payment of approximately $175 million , subject to certain adjustments, and additional payments of up to $322 million that will be paid to the shareholders of Cell Design Labs other than Kite upon the occurrence of certain events, including the achievement of development and approval milestones. (deutschland-schraubt.de)
  • MD, PhD, Chairman of the Board of Directors for Cell Design Labs . (deutschland-schraubt.de)
  • cancer
  • We've revealed multiple new signaling pathways that regulate cell death," said Sally Kornbluth, PhD, vice dean of Basic Science and professor of Pharmacology and Cancer Biology at Duke University School of Medicine. (medicalxpress.com)
  • Only in the presence of an FDA-approved small molecule drug will the two components come together - closing the "switch" - into an active state, seeking out and eliminating cancer cells. (globenewswire.com)
  • I am enthusiastic about working with NeoStem, Inc. to further develop the potential of VSELs," said Mariusz Z. Ratajczak, M.D., Ph.D., a co-inventor of the VSEL technology and head of the Stem Cell Biology Program at the James Graham Brown Cancer Center at the University of Louisville. (technologynetworks.com)
  • Colorectal cancer stem cells acquire chemoresistance through the upregulation of FBXW7 and the conse. (kumamoto-u.ac.jp)
  • Upregulation of FBXW7 following drug treatment was not evident in commercially available cancer cell lines. (kumamoto-u.ac.jp)
  • lymphocytes
  • This cell line exhibits phenotypical and functional characteristics of freshly isolated CD8α + DCs, i.e., expression pattern of surface markers, potent costimulation, cross-presentation of antigens, and induction of cytotoxic responses by CD8 + T lymphocytes ( 9 ). (frontiersin.org)
  • immune cells
  • Peter Emtage, Ph.D., Chief Scientific Officer said, "We are on the cusp of a new era in medicine where we are able to precisely instruct and guide immune cells to recognize and eliminate disease. (globenewswire.com)
  • retroviruses
  • Whether or not HTLV-I or other retroviruses of this family with T-cell tropism cause AIDS, it is possible that patients from whom the virus can be isolated can also transmit it to others. (sciencemag.org)
  • Editorial Note: HTLV agents are retroviruses that have recently been associated with certain types of adult T-cell lymphoreticular neoplasms of man (6). (cdc.gov)
  • tissue
  • Without these memories, cells fail to organize into distinct tissue types. (technologynetworks.com)
  • Elanix Biotechnologies Ltd. (Frankfurt: ELN) develops and commercializes tissue regeneration products for acute wound care, dermatological and gynecological applications, and provides services in cell technologies. (businesswire.com)
  • Progenitor cells are fully differentiated yet immunologically neutral cells that are very potent inducers of tissue growth and healing. (businesswire.com)