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  • progression
  • This S-phase checkpoint responds to various forms of DNA damage, such as single-and double-strand breaks in the DNA backbone or incorporation of unusual nucleotides , and halts the progression of the cell cycle until effective repairs have occurred. (biologyreference.com)
  • Since then, checkpoints have been discovered that regulate many aspects of cell-cycle progression in all organisms studied. (biologyreference.com)
  • Title: DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage. (nih.gov)
  • Dynamic protease localization mediated by a phospho-signaling pathway is a novel mechanism to integrate spatial and temporal control of bacterial cell cycle progression. (pnas.org)
  • Untreated lesions have up to a 20% risk of progression to squamous cell carcinoma, so treatment by a dermatologist is recommended. (wikipedia.org)
  • The Caulobacter cell cycle regulatory system controls many modular subsystems that organize the progression of cell growth and reproduction. (wikipedia.org)
  • chromosomal
  • Though a generic cell cycle possesses no definitive starting stage, the term 'start' of the cell cycle has nonetheless been given to the initiation of chromosomal DNA replication or synthesis. (biologyreference.com)
  • The aceticorcein squash technique has been used to describe the chromosomal organization in two cell types known to hypertrophy without sign of an M -phase: oenocytes of the locust Schistocerca gregaria , and the giant trophoblast cells of mouse concepti. (biologists.org)
  • The occurrence of some chromosomal anomalies may lend mutated cells the capacity to divide up an infinite number of times. (inserm.fr)
  • A single type of chromosomal rearrangement was observed: duplication of long arm chromosome 1 (arm 1q), accompanied by a translocation of this supernumerary arm to another chromosome (random). (inserm.fr)
  • This type of chromosomal anomaly has already been described in haematological malignancies under the name of "jumping translocation", and sometimes in solid tumours (breast cancer, hepatocellular carcinoma, retinoblastoma, paediatric brain tumours). (inserm.fr)
  • An additional interesting result of this research: it is not one of the chromosomal anomalies identified in the undifferentiated pluripotent stem cells, which means that it did not predate the differentiation of neural progenitors, it appeared afterwards. (inserm.fr)
  • In Burkitt lymphoma, cancer cells show chromosomal translocations, in which chromosome 8 is frequently involved. (wikipedia.org)
  • growth
  • 3. Actively dividing non-organized masses of undifferentiated and differentiated cells often developing from injury (wounding) or in tissue culture in the presence of growth regulators. (fao.org)
  • These monumental transformations in the chromosomes are accompanied by general cell growth, which provides enough material of all sorts (membranes, organelles , cytosol , nucleoplasm) required for the resultant doubling of cell number. (biologyreference.com)
  • The integration of cell division, growth and differentiation. (uni-hamburg.de)
  • The cell cycle is the process of cell growth and division. (getrevising.co.uk)
  • Loss of FBL17 function drastically reduces plant growth by altering cell division activity in both shoot and root apical meristems. (plantcell.org)
  • For example, assisted by the cell line's high differentiation rate and fusion rate, fibronectin templates can be micro-plated to petri dishes or cell culture flasks in order to induce specific growth patterns, such as that of mimicking skeletal muscle cell interactions with extracellular matrix components. (wikipedia.org)
  • The introduction of adhesion molecules can alter the growth pattern of C2C12 cells to a longitudinal distribution exhibiting polarity. (wikipedia.org)
  • The term cell growth is used in the contexts of biological cell development and cell division (reproduction). (wikipedia.org)
  • Cell populations go through a particular type of exponential growth called doubling. (wikipedia.org)
  • A population's "growth fraction" - or the fraction of the population that was growing - was actively proliferating, but other cells existed in a non-proliferative state. (wikipedia.org)
  • G1 cyclins do not behave like the other cyclins, in that the concentrations increase gradually (with no oscillation), throughout the cell cycle based on cell growth and the external growth-regulatory signals. (wikipedia.org)
  • The presence of G cyclins coordinate cell growth with the entry to a new cell cycle. (wikipedia.org)
  • Yet, Caulobacter has the swarmer cell stage that results in slower population growth. (wikipedia.org)
  • YPEL3 has growth inhibitory effects in normal and tumor cell lines. (wikipedia.org)
  • Initially discovered in a gene expression profiling assay of p53 activated MCF7 cells, induction of YPEL3 has been shown to trigger permanent growth arrest or cellular senescence in certain human normal and tumor cell types. (wikipedia.org)
  • genetic
  • Nathalie Lefort's team has been focussing on neural progenitors of the same type, resulting from the differentiation of pluripotent stem cells of an "iPS" embryonic or lined origin (induced pluripotent through the genetic reprogramming of adult cells). (inserm.fr)
  • When used in the context of cell development, the term refers to increase in cytoplasmic and organelle volume (G1 phase), as well as increase in genetic material (G2 phase) following the replication during S phase. (wikipedia.org)
  • predivisional
  • In contrast, the stalked daughter cell immediately initiates chromosome replication, followed by elongation into a predivisional cell and biosynthesis of a new flagellum and chemotaxis apparatus at the pole opposite the stalk. (pnas.org)
  • In strain NA1000, which was derived from CB15 in the 1970s, the stalked and predivisional cells can be physically separated in the laboratory from new swarmer cells, while cell types from strain CB15 cannot be physically separated. (wikipedia.org)
  • adult
  • Hematopoietic stem cells (HSCs) are the best-described adult stem cell population at a phenotypic and functional level. (pubmedcentralcanada.ca)
  • These include each of the more than 220 cell types in the adult body. (wikipedia.org)
  • However, these problems associated with histocompatibility may be solved using autologous donor adult stem cells, therapeutic cloning. (wikipedia.org)
  • For example, most adult neuronal cells, among the most metabolically active cells in the body, are fully differentiated and reside in a terminal G0 phase. (wikipedia.org)
  • Initiation
  • Rapid clearance of the master regulator, CtrA, by the ClpXP protease is a critical event that enables the initiation of chromosome replication at specific times in the cell cycle. (pnas.org)
  • This differentiation process includes the loss of the flagellum and the polar chemotaxis receptors, retraction of the pili, construction of a stalk at the cell pole previously occupied by the flagellum, and initiation of chromosome replication. (pnas.org)
  • In swarmer cells, CtrA∼P also represses initiation of chromosome replication by binding to five sites in the origin of replication ( 7 ). (pnas.org)
  • Clearance of CtrA∼P from the stalked cell at the swarmer-to-stalked cell transition, or from the stalked cell compartment at cell division, by simultaneous dephosphorylation and degradation enables initiation of chromosome replication. (pnas.org)
  • Their expression is also being measured by flow cytometry concurrently with the initiation and termination of DNA replication during S-phase Cyclins are generally very different from each other in primary structure, or amino acid sequence. (wikipedia.org)
  • stem cell
  • Because of their plasticity and potentially unlimited capacity for self-renewal, embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. (wikipedia.org)
  • Besides the ethical concerns of stem cell therapy (see stem cell controversy), there is a technical problem of graft-versus-host disease associated with allogeneic stem cell transplantation. (wikipedia.org)
  • Stem cells are cells with the unique ability to produce differentiated daughter cells and to preserve their stem cell identity through self-renewal. (wikipedia.org)
  • swarmer cells
  • A ) Swarmer cells of a strain expressing cpdR-yfp from a low copy-number plasmid in a wild-type background were harvested, resuspended on an agarose pad, and, thereafter, imaged by DIC and fluorescence microscopy every 45 min. (pnas.org)
  • The isolated swarmer cells can then be grown as a synchronized cell culture. (wikipedia.org)