Loading...
  • efficacious
  • The non-pegylated liposomes are stable, exhibit low toxicity and have been found to be efficacious in different tumor models. (google.it)
  • Recently, purine nucleoside analogues have been shown to be efficacious in the therapy of CLL and other indolent B-cell malignancies. (aacrjournals.org)
  • Our results suggest that strategies combining bioreductively activated hypoxic cell cytotoxins and biological agents might offer efficacious alternatives or adjuvants to conventional combination approaches. (aacrjournals.org)
  • neoplastic cells
  • Pubmed ID: 24778021 Sonodynamic therapy (SDT) is a form of ultrasound therapy in which chemotherapeutic agents known as sonosensitizers are administered to increase the efficacy of ultrasound's preferential damage to neoplastic cells. (jove.com)
  • 10 W/cm(2)) to determine whether this approach elicited the preferential damage of neoplastic cells over normal blood components. (jove.com)
  • models
  • It is one of the so-called DACH (1, 2-Diamincyclohexane)-containing platinum complexes that exhibited activity in Murine L1210 leukemia tumor models possessing acquired resis tance to cisplatin. (encyclopedia.com)
  • He was also the first person to document the effectiveness of animal models to screen a series of chemicals for their potential activity against diseases, an accomplishment that had major ramifications for cancer drug development. (aacrjournals.org)
  • The major limitations of drug discovery were two-fold: first, the development of models that could effectively be used to reduce the vast repertoire of chemicals to those few that might have activity against cancer in humans, and second, the access to clinical facilities to test such agents. (aacrjournals.org)
  • malignant cells
  • The therapeutic method combines ultrasonic irradiation with drugs known as sonosensitizers that amplify its ability to inflict preferential damage on malignant cells. (jove.com)
  • resistance
  • Chronic lymphocytic leukemia (CLL) lymphocytes respond to DNA alkylation by excision repair, with the extent of repair increasing as the cells acquire resistance to alkylating agents. (aacrjournals.org)
  • Studies are in progress to determine the methylation status of the XPG gene in the nemorubicin-resistant cell line.In conclusion, these results further corroborate the unique mechanism of action of nemorubicin and identify a novel mechanism of drug resistance through the genetic silencing of a DNA repair gene. (aacrjournals.org)
  • acute
  • The constituents were later approved as vinblastine, used to treat Hodgkins disease, and vincristine, used to treat acute childhood leukemia (826). (quackwatch.org)
  • The ability of combination chemotherapy to cure acute childhood leukemia and advanced Hodgkin's disease in the 1960s and early 1970s overcame the prevailing pessimism about the ability of drugs to cure advanced cancers, facilitated the study of adjuvant chemotherapy, and helped foster the national cancer program. (aacrjournals.org)
  • facilitate
  • Because incorporation of nucleotide analogues into the repair patches elicits death signals in quiescent cells, the increased capacity for excision repair in alkylator-resistant cells could facilitate incorporation of nucleotide analogues. (aacrjournals.org)
  • combinations
  • The combinations also produced marked decreases in the yield of viable tumor cells, suggesting that the bioreductive drugs may have also potentiated the microvascular injury and ischemia produced by IL-1α. (aacrjournals.org)
  • NK cells obtained by exposing mouse fetal thymocytes to appropriate combinations of IL-4, IL-2, and PMA are phenotypically indistinguishable from cultured adult splenic NK cells with the exception that they generally lack measurable expression of all of the inhibitory Ly49 molecules that can currently be detected with Abs (Ly49A, -C, -G, and -I) and of the activating molecule Ly49D. (jimmunol.org)
  • cancer
  • Oxaliplatin is an investigational chemotherapy medicine used to treat certain types of cancer by destroying cancerous cells. (encyclopedia.com)
  • These platinum-containing drugs interfere with the genetic material, or DNA, inside the cancer cells and prevent them from further dividing and growing more cancer cells. (encyclopedia.com)
  • Etoposide was approved by FDA in 1983 for use in patients with refractory testicular tumors, small-cell lung cancer, nonlymphocytic leukemias, and non-Hodgkins lymphoma (424). (quackwatch.org)
  • The use of chemotherapy to treat cancer began at the start of the 20th century with attempts to narrow the universe of chemicals that might affect the disease by developing methods to screen chemicals using transplantable tumors in rodents. (aacrjournals.org)
  • The polyamine transport system (PTS) is an energy-dependent machinery frequently overactivated in cancer cells with a high demand for polyamines. (topogen.com)
  • We have exploited the PTS to selectively deliver a polyamine-containing drug to cancer cells. (topogen.com)
  • elicit
  • We hypothesized that the mechanism-based interaction of nucleoside analogues with alkylating agents could elicit greater than additive killing of CLL cells. (aacrjournals.org)
  • Photodynamic therapy ( PDT ), is a form of phototherapy involving light and a photosensitizing chemical substance, used in conjunction with molecular oxygen to elicit cell death ( phototoxicity ). (wikipedia.org)
  • additive
  • Combining 4-HC with either F-ara-A or Cl-F-ara-A produced more than additive apoptotic cell death than the sum of each alone. (aacrjournals.org)
  • model
  • A mechanistic, predictive model of dose-response curves for cell cycle phase-specific and -nonspecific drugs. (semanticscholar.org)
  • A major breakthrough in model development occurred in the early 1910s when George Clowes of Roswell Park Memorial Institute (RPMI) in Buffalo, New York, Roswell Park Memorial Institute developed the first transplantable tumor systems in rodents. (aacrjournals.org)
  • growth
  • The reduction in enzyme activities led to sufficient reduction of d(NTP) levels to suppress DNA synthesis and cell growth. (docme.ru)
  • We first tested the effects of CPCD using the MTT growth assay in mouse embryonic endothelial cell line (MEEC) treated with or without increasing concentration of CPCD for up to 72 h. (scienceofgreathealth.com)
  • molecule
  • Both the frequency of cells expressing a given Ly49 molecule and the level of expression are influenced by host MHC genes ( 6 , 7 , 8 ). (jimmunol.org)
  • molecular
  • molecular analysis of these defects highlighted XPG as a crucial gene, being expressed at the protein level in L1210 wild type cells but not in the nemorubicin-resistant subline. (aacrjournals.org)
  • substantially
  • A problem with this concept, and with negative signaling in general, is that since the level of class I expression varies substantially on different cells in the body there would appear to be a continuous need to adjust the level at which self-nonself discrimination is set in individual NK cells. (jimmunol.org)
  • dose
  • The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95. (semanticscholar.org)
  • pathway
  • The major site of inhibition was in the pyrimidine de AOUO synthetic pathway at orotidine monophosphate decarboxylase activity. (docme.ru)
  • Although the existence of NK cells has been known for more than 20 years, many of the basic issues concerning these cells, such as their developmental pathway, their mechanisms of recognition, and their physiologic function, are still poorly understood. (jimmunol.org)
  • cellular
  • The spermine tail of F14512 serves as a cell delivery vehicle as well as a DNA anchor, and this property translates at the cellular level into a distinct pharmacologic profile. (topogen.com)
  • different
  • Different members of the Ly49 family bind to different class I molecules and are expressed independently on overlapping subpopulations of NK cells ( 5 ). (jimmunol.org)
  • mouse
  • To check whether apoptosis added to the entire development inhibition, annexin-V staining was performed in MEECs and isolated principal mouse aortic endothelial cells (MAECs). (scienceofgreathealth.com)
  • In the mouse, the NK1.1 Ag, which is a homologue of NKRP1 ( 15 ), is expressed on all NK cells in appropriate strains ( 16 ), is encoded by genes in the NK complex ( 4 ), and may be involved in recognition as judged by the ability of Ab to NK1.1 to induce or enhance killing by NK cells ( 17 ). (jimmunol.org)
  • Recent studies have indicated that the 10A7 Ab, which reacts with most but not all mouse NK cells ( 18 ), binds to one or more members of the mouse NKRP1 family (J. C. Ryan and W. E. Seaman, personal communication) and may therefore delineate a subpopulation of NK cells with distinct recognition capabilities. (jimmunol.org)
  • significant
  • Recently, a significant advance in our understanding of NK cell recognition has come from the realization that MHC class I molecules can protect target cells from lysis by NK cells ( 1 ). (jimmunol.org)
  • signals
  • This protection is mediated at least in part by receptors on NK cells that bind to class I molecules and deliver inhibitory signals ( 2 , 3 ). (jimmunol.org)
  • Ly49D is expressed on a subpopulation of NK cells and may convey activating signals ( 12 ). (jimmunol.org)
  • sufficient
  • If sufficient oxidative damage ensues, this will result in target-cell death (only within the illuminated area). (wikipedia.org)
  • distinct
  • The expression of individual variable Ags is independent and stochastic, resulting in fetal NK "clones" being potentially composed of hundreds of phenotypically distinct cells. (jimmunol.org)
  • level
  • Subsequent real-time PCR analysis demonstrated that L1210/MMDX cells did not express the XPG gene at the mRNA level, suggesting a transcriptional silencing. (aacrjournals.org)